検索結果 2926 件
| JaLCDOI | 10.18926/40143 |
|---|---|
| タイトル（別表記） | Rheumatoid arthritis and Sjögren's syndrome |
| フルテキストURL | 042_031_045.pdf |
| 著者 | 市川 幸延| |
| 抄録 | 1. Parotid Sialography Parotid sialograms were investigated in 29 patients with classical or definite RA according to the criteria of the American Rheumatism Association (one of whom had scleroderma), 5 patients with SLE (according to the Dubois's criteria, three were definite, one probable and another possible SLE), 3 patients with other autoimmune diseases (Hashimoto's thyroiditis, colitis ulcerosa and undiagnosed collagen disease), 3 patients with polyarthralgia and 10 patients with nonautoimmune diseases. Sialographic technique was performed by modified Rubin's Method using contrast medium Conray-400. Sialectasis which is pathognomonic of Sjögren's syndrome (SS) alone was observed in 6 patients with RA (20.7%) (3 punctate and 3 globular patterns) and 2 patients with SLE (one punctate and another globular pattern). Retention of the contrast medium in the duct for at least 5 minutes after the injection was observed in patients with RA, one patient with SLE and one patient with colitis ulcerosa. Sial ectasis and retention almost always existed together, and were observed in patients from young to older one. Although dilatation of the Stensen's duct and subalveolar dissection also existed together, they were observed in only older patients. It appeared that the former is the specific findings of SS and the latter is the non-specific findings according to the aging. Dry mouth was complained in 7 sialectasis (87.5%), 3 subalveolar dissection (60.0%), 10 retention (62.5%) and 9 normal sialogram (37.5%). Salivary hyposecretion (less than 10 ml/10min) was observed in 4 sialectasis (50%), one subalveolar dissection (20%), 6 dilatation of the Stensen's duct (37.5%), 5 retention (45.5%) and one normal sialogram (4.2%). These results show that sialectasis and retention are well correlated with salivary hyposecretion, but dry mouth is not so diagnostic in SS. Two patients with SLE had sialectasis were young women and showed normal salivary and lacrimal secretion. These cases may be supported by Heaton's hypothesis that SS is a benign and chronic form of SLE, or thay may be a subclinical state of SS. 2. Schirmer test Sixty seven patients (36RA, 6SLE, 3 other autoimmune diseases, 3 polyarthralgia and 19 non-autoimmune diseases) were examined by Schirmer test. Besides lacrimal hyposecretion was observed in RA and other autoimmune diseases, it began in younger age. These results show that autoimmune diseases have a sicca element in themselves. Compared with the results of sialography, Schirmer test was not correlated with sialectasis and retention. Dry eye was complained in only 4 patients (13.3%) with lacrimal hyposecretion (less than 10mm/5min) and all patients with dry eye had keratoconjunctivitis sicca (KCS). Dry eye is more diagnostic than Schirmer test. 3. Corneal staining by 1% rose bengal solution Twenty five patients with RA or SLE were examned corneal staining (Holm's type A) was observed in 5 patients with RA (20%). Staining of the medial and lateral bulbar conjunctiva (Holm's type B and C) were observed in 6 patients with RA (24%) and one patient with SLE. Nine patients with positive staining (type A, B and C) (75%) showed lacrimal hyposecretion. Dry eye was complained in 4 patients with type A staining (80%), but no patient with type B and C complained dry eye. Dry eye appears to be specific for the diagnosis of SS as sialectasis on the sialogram. 4. Salivary secretion All amount of saliva was collected during ten minutes chewing two pieces of gum. All of 21 patients with non-autoimmune diseases showed more than 10 ml/10min, and slight degree of salivary hyposecretion was observed with aging. Nine patients with RA (25.7%) showed salivary hyposecretion (less than 10ml/10min), besides it began in younger age. It was also observed in patients with other autoimmune diseases. Only 36.4% patients with salivary hyposecretion showed sialectasis on the sialogram. It can be supposed that patients with sialectasis and good salivary secretion are subclinical states of SS, and that this state is depends on the compensative function of the glands. Therefore, it is impossible to suppose the salivary dysfunction from the complaints of patients alone. It is required that saliva must be analysed not only quantitativly but also qualitativly (such as RA factor, complement and lysozome). Dry mouth was not only complained in 9 patients who showed salivary hyposecretion (81.8%). but in 10 patients showed normal secretion (50%). Dry mouth appears to be less specific for the diagnosis of SS than dry eye. 5. Diagnosis of SS Vanslow's criteria of SS was modified as follows. (1) Major : ① Sialectasis or salivary gland enlargement ② Positive corneal staining (type A) ③ Classical or definite RA (according to the criteria of the ARA) (2) Minor : ① Arthritis ② History ot salivary gland swelling ③ Dry mouth or salivary hyposecretion (less than 10ml/10min) ④ Dry eye or positive Schirmer test (less than 10mm/5min). Three major was diagnosed as definite, 2 major as probable and one major with one or more minor as possible SS. Of 35 patients with RA, definite (8.6%), probable (17.1%) and possible SS (54.3%) were obserevd. Two of SLE (33.3%) were possible SS. One patients with undiagnosed collagen disease was possible SS. Clinically, definite and probable SS may be diagnosed as Sjögren's syndrome. Two possible SS with SLE may be supporsed as subclinical states of SS who do not yet exhibite full criteria. Compared with the clinical and laboratory findings of these definite, probable and possible SS with RA, it was supporsed that positive antinuclear factor or positive LE cells in RA patients almost always represents SS, drug allergy, especially to gold therapy may be a manifestation of SS. Hypergammaglobulinemia, extreme elevation of erythrocyte sedimentation rate, struma, lymphnode enlargement in RA patients must be suspected of SS. Although one possible SS with SLE and one probable SS with RA showed positive ANF (peripheral pattern), it is impossible to differentiate SS from SLE by ANF alone. Because Suzuki et al. reported that 15.4% of SS had showed positive ANF (peripheral pattern). Examinations of salivary glands including sialography must be performed in patients with SLE in the future. To detect a subclinical SS, sialography and corneal staining must be performed even in patients with no sicca symptom, because of the compensatory functions of salivary and lacrimal glands. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1973-03-25 |
| 巻 | 42巻 |
| 開始ページ | 31 |
| 終了ページ | 45 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40017532309 |
| JaLCDOI | 10.18926/40136 |
|---|---|
| タイトル（別表記） | Oxygen Isotopic Composition of Water in the Living Things : Preliminary Analyses and Discussions |
| フルテキストURL | pitsr_044_061_075.pdf |
| 著者 | 木島 宣明| |
| 抄録 | Oxygen isotope analysis was carried out, by use of a new method (oxalate equilibration method) of preparing CO(2) for mass spectrometry, on water samples extracted from a number of biological samples collected in Misasa Town and Hashizu Coast, Tottori Prefecture. The δ values (the per mil enrichment of (18)O in sample waters relative to the Standard Mean Ocean Water) were suggested to be distributed in the living things as follows. The water absorbed by plant roots was supposed to have the same δ value with the water outside it (δs. about -8‰), and in a rapidly transpiring plant, this water reached the leaves, partly infiltrating into the phloem. When transpiration was slow, on the other hand, the isotopic composition of ascending xylem sap was modified by the exchange of water with phloem. where leaf water with a higher δ value was migrating. As Gonfiantini et aI. (1965) and Dongmann et al. (1972) have odserved, leaf waters were enriched markedly in (18)O in the daytime. A criterion of the δ of leaf water may be the sum of δs and △δ that corresponds to the (18)O fractionation factor in the H(2)O(I)-H(2)O(v) system. The sum comes to about 0‰ at ordinary leaf temperatures. and really δ values near 0‰ were observed in leaves of some herbaceous plants, in exudate from a tip of vine of Kudzu, in body fluid of herbivorous insects, etc., but higher δs (up to +19‰) were also observed in some other leaves such as pine needles, Especially leaves showed an increase in δ by about 10 ‰ toward the pnd of November when the average temperature fell below 10℃, probably because of accumulation of the daily enrichment as a resul t of slow water absorption and circulation. A few plant species grown on a dune were analyzed and it seemed that, among them, herbaceous plants were dependent on spraied sea water and pine trees on ground water. δ's of petal water were dispersed (-9～-3‰), probably according to the volume-to-transpirational flux ratio of water in the petals. Succurent fruits in enlarging stage seemed to have lower δ's near δs, but in maturing stagp δ's increaspd to about -4‰, i.e., to the avpraged δ of Ieaf water in the day and night. Herbivorous insects (imagines and la rvae) in general had distinctly higher δ values than carnivorous insects, the border being at -1‰. However, lower δ's at about -5‰ were obserbed on aphides which might have been sucking somewhat dilutpd leaf water from seave tube cells. Sometimes the δ of a herbivorous insect was a few per mil higher than that of the leaf it was nibbling, probably as a result of evaporation of water from the insect and of respiration. The level at about -3‰ common for carnivorous insects could not be explained, although tipula and chironomus making a swarm also showed a δ value on the level. Blood of a heron did not show such a low δ as supposed from its food habit. As compared with the drinking water of -8‰, blood and urine were found to have an identical δ in the range of -4 to -5‰ in either mouse or man, The δ value of the oxidation water produced in man's body was estimated to be about -6‰ from an approximate water balance. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1975-03-25 |
| 巻 | 44巻 |
| 開始ページ | 61 |
| 終了ページ | 75 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002383784 |
| 著者 | 山本 悦世| 忽那 敬三| 光本 順| 岩﨑 志保| 能城 修一| |
|---|---|
| 発行日 | 2004-02-27 |
| 出版物タイトル | 岡山大学構内遺跡発掘調査報告 |
| 巻 | 19巻 |
| 資料タイプ | 研究報告書 |
| 著者 | 岩﨑 志保| 野崎 貴博| 横田 美香| |
|---|---|
| 発行日 | 2003-03-26 |
| 出版物タイトル | 岡山大学構内遺跡発掘調査報告 |
| 巻 | 17巻 |
| 資料タイプ | 研究報告書 |
| 著者 | 吉田 裕一| 松野 大樹| 後藤 丹十郎| 高田 圭太| |
|---|---|
| 発行日 | 2010-04-01 |
| 出版物タイトル | 岡山大学農学部センター報告 |
| 巻 | 32巻 |
| 資料タイプ | 紀要論文 |
| 著者 | 佐々木 恭子| |
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| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 一般雑誌記事 |
| 著者 | 宮﨑 俊明| 錦織 淳美| 松永 尚| 千堂 年昭| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 藤原 一夫| 遠藤 裕介| 三宅 由晃| 尾﨑 敏文| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 永坂 岳司| 田中 紀章| 孫 冬生| 猶本 良夫| 松原 長秀| 八木 孝仁| 藤原 俊義| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 内富 庸介| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 田邊 賢司| 竹居 孝二| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 古松 毅之| 尾﨑 敏文| 浅原 弘嗣| |
|---|---|
| 発行日 | 2010-08-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 122巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Teraishi, Fuminori| Kagawa, Shunsuke| Watanabe, Takanori| Tango, Yasuhisa| Kawashima, Takeshi| Umeoka, Tatsuo| Nisizaki, Masahiko| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| 発行日 | 2005-08-01 |
| 出版物タイトル | FEBS Letters |
| 巻 | 579巻 |
| 号 | 19号 |
| 資料タイプ | 学術雑誌論文 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kadota, Isao| Abe, Takashi| Uni, Miyuki| Takamura, Hiroyoshi| Yamamoto, Yoshinori| |
| キーワード | POLYCYCLIC ETHERS ABSOLUTE-CONFIGURATION HYDROXY GROUP MOIETY FRAGMENT SYSTEM ROUTE CTX3C |
| 備考 | Published with permission from the copyright holder. This is a author's copy,as published in Tetrahedron Letters , 2008 Vol.49 Issu.22 pp.3643-3647 | |
| 発行日 | 2008-06-19 |
| 出版物タイトル | Tetrahedron Letters |
| 巻 | 49巻 |
| 開始ページ | 3643 |
| 終了ページ | 3647 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1016/j.tetlet.2008.03.145 |
| Web of Science KeyUT | 000256043100025 |
| 著者 | Ali, Hamed I.| Ashida, Noriyuki| Nagamatsu, Tomohisa| |
|---|---|
| 発行日 | 2007-10-01 |
| 出版物タイトル | Bioorganic & Medicinal Chemistry |
| 巻 | 15巻 |
| 号 | 19号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Kondo, Kazuo| Yonezawa, Toshihiro| Mikami, Daisuke| Okubo, Toshikazu| Taguchi, Yuichi| Takahashi, Kenji| Barkey, Dale P| |
|---|---|
| 発行日 | 2005-09 |
| 出版物タイトル | Journal of the Electrochemical Society |
| 巻 | 152巻 |
| 号 | 11号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Babazono, Akira| Tsuda, Toshihide| Yamamoto, Eiji| Mino, Yoshio| Une, Hiroshi| Hillman, Alan L.| |
|---|---|
| 発行日 | 2003-8 |
| 出版物タイトル | International Journal of Technology Assessment in Health Care |
| 巻 | 19巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Fujioka, Shinsuke| Nishimura, Hiroaki| Nishihara, Katsunobu| Sasaki, Akira| Sunahara, Atsushi| Okuno, Tomoharu| Ueda, Nobuyoshi| Ando, Tsuyoshi| Tao, Yezheng| Shimada, Yoshinori| Hashimoto, Kazuhisa| Yamaura, Michiteru| Shigemori, Keisuke| Nakai, Mitsuo| Nagai, Keiji| Norimatsu, Takayoshi| Nishikawa, Takeshi| Miyanaga, Noriaki| Izawa, Yasukazu| Mima, Kunioki| |
|---|---|
| 発行日 | 2005-11 |
| 出版物タイトル | Physical Review Letters |
| 巻 | 95巻 |
| 号 | 23号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Hachisuka, Hidekazu| Awaga, Kunio| Yokoyama, Toshihiko| Kubo, Takeji| Goto, Takao| Nojiri, Hiroyuki| |
|---|---|
| 発行日 | 2004-9 |
| 出版物タイトル | Physical Review B |
| 巻 | 70巻 |
| 号 | 10号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Takeuchi, Kasumi| Ono, Hiroshi| Yoshida, Mitsuru| Ishii, Tadashi| Katoh, Etsuko| Taguchi, Fumiko| Miki, Ryuji| Murata, Katsuyoshi| Kaku, Hanae| Ichinose, Yuki| |
|---|---|
| 発行日 | 2007-10 |
| 出版物タイトル | Journal of Bacteriology |
| 巻 | 189巻 |
| 号 | 19号 |
| 資料タイプ | 学術雑誌論文 |