検索条件

閉じる

検索結果 3251 件

フルテキストURL K0006050_abstract_review.pdf K0006050_fulltext.pdf
著者 MD ARSHAD ALI|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6050号
学位授与年月日 2019-09-25
学位・専攻分野 博士(工学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006039_abstract_review.pdf K0006039_fulltext.pdf
著者 徐 乃進|
発行日 2019-09-25
資料タイプ 学位論文
学位授与番号 甲第6039号
学位授与年月日 2019-09-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL fcell_2019_00160_p.pdf fcell_2019_00160_a.pdf
著者 Satoh, Ayano| Hayashi-Nishino, Mitsuko| Shakuno, Takuto| Masuda, Junko| Koreishi, Mayuko| Murakami, Runa| Nakamura, Yoshimasa| Nakamura, Toshiyuki| Abe-Kanoh, Naomi| Honjo, Yasuko| Malsam, Joerg| Yu, Sidney| ishino, Kunihiko |
キーワード Golgi golgins glycosylation endoplasmic reticulum electron tomography
発行日 2019-08-27
出版物タイトル Frontiers in Cell and Developmental Biology
巻 7巻
開始ページ 160
ISSN 2296634X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 31544102
DOI 10.3389/fcell.2019.00160
関連URL isVersionOf https://doi.org/10.3389/fcell.2019.00160
フルテキストURL RSocOpenSci_6_5_190293_p.pdf
著者 Tani, Yumeki| Kaneta, Takashi|
キーワード gold nanoparticle optical force vesicles
発行日 2019-05-15
出版物タイトル Royal Society Open Science
巻 6巻
号 5号
出版者 Royal Society Publishing
開始ページ 190293
ISSN 20545703
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 31218066
DOI 10.1098/rsos.190293
関連URL isVersionOf https://doi.org/10.1098/rsos.190293
フルテキストURL AnalytMethods_2019_11_179.pdf
著者 Hashimoto, Yuki| Kaneta, Takashi|
備考 This fulltext will be available in Dec 2019|
発行日 2018-12-10
出版物タイトル Analytical Methods
巻 11巻
出版者 Royal Society of Chemistry
開始ページ 179
終了ページ 184
ISSN 17599660
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
DOI 10.1039/C8AY02298D
関連URL isVersionOf https://doi.org/10.1039/C8AY02298D
JaLCDOI 10.18926/AMO/57379
フルテキストURL 73_5_469.pdf
著者 Yamasaki, Satoshi| Kada, Akiko| Nagai, Hirokazu| Yoshida, Isao| Choi, Ilseung| Saito, Akiko M.| Iwasakia, Hiromi|
抄録 Romidepsin is an important therapeutic option for patients with peripheral T-cell lymphoma (PTCL). However, the timing of romidepsin administration remains controversial. Romidepsin was launched in Japan as a consolidation therapy agent after conventional salvage chemotherapy with gemcitabine, dexamethasone, and cisplatin (GDP). GDP therapy will be administered every 3 weeks. If complete response, partial response, or stable disease is confirmed after 2-4 GDP cycles, romidepsin will be administered every 4 weeks. The primary endpoint is a 2-year progression-free survival rate. Patients participating in this study and undergoing treatment can expect results similar to or better than those of conventional therapies.
キーワード peripheral T-cell lymphoma not otherwise specified angioimmunoblastic T-cell lymphoma gemcitabine cisplatin, romidepsin
Amo Type Clinical Study Protocol
出版物タイトル Acta Medica Okayama
発行日 2019-10
巻 73巻
号 5号
出版者 Okayama University Medical School
開始ページ 469
終了ページ 474
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649375
Web of Science KeyUT 000491886600014
JaLCDOI 10.18926/AMO/57374
フルテキストURL 73_5_433.pdf
著者 Tamada, Shoko| Mitsui, Takashi| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eguchi, Takeshi| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi|
抄録 An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia.
キーワード preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
巻 73巻
号 5号
出版者 Okayama University Medical School
開始ページ 433
終了ページ 440
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649370
Web of Science KeyUT 000491886600009
JaLCDOI 10.18926/AMO/57373
フルテキストURL 73_5_427.pdf
著者 Owari, Yutaka| Suzuki, Hiromi| Miyatake, Nobuyuki|
抄録 The aim of this study was to examine in a randomized controlled trial how much the sedentary behavior (sitting time) of community-dwelling elderly Japanese subjects decreased as a result of using the “Active Guide” brochure published by the Ministry of Health, Labour and Welfare (2013) and additional documents related to the benefits of reducing sedentary behavior. A total of 86 elderly people who participated in health-club activities for one year were randomly allocated to two groups. Subjects in the intervention group received explanations of the importance of physical activity using the “Active Guide” brochure (n=42) and additional documents, while subjects in the control group did not (n=44). Physical activity was measured using a triaxial accelerometer for two weeks at baseline and again after one year. After one year of intervention, the difference in the sedentary behavior rate from baseline was −2.2% for the intervention group (n=40) and +2.5% for controls (n=40) (Welch’s t-test, p=0.007). Use of the “Active Guide” brochure and additional documents may reduce the sedentary behavior of community dwelling elderly people in Japan.
キーワード Active Guide sedentary behavior elderly people randomized controlled trial health promotion
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
巻 73巻
号 5号
出版者 Okayama University Medical School
開始ページ 427
終了ページ 432
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649369
Web of Science KeyUT 000491886600008
JaLCDOI 10.18926/AMO/57372
フルテキストURL 73_5_419.pdf
著者 Hishii, Shuhei| Miyatake, Nobuyuki| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Koumoto, Kiichi| Suzuki, Hiromi| Hashimoto, Hiroo|
抄録 We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups’ clinical parameters. We compared the groups’ survival rates by using Kaplan-Meier curves and the log-rank test, and we performed multivariate analyses by a Cox-proportional hazard model to evaluate the relationship between the sedentary behavior and the survival rate. Twenty patients (28.2%) died during the observation period. The survival rate of the short-SB group was significantly higher than that of the long-SB group. Sedentary behavior was thus an important factor for all-cause mortality even after adjusting for confounding factors by a Cox-proportional hazard model. Sedentary behavior is closely linked to all-cause mortality, especially total days and non-hemodialysis days, and reducing sedentary behavior may be beneficial to reduce the all-cause mortality of patients on chronic hemodialysis.
キーワード sedentary behavior hemodialysis mortality physical activity
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
巻 73巻
号 5号
出版者 Okayama University Medical School
開始ページ 419
終了ページ 425
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649368
Web of Science KeyUT 000491886600007
JaLCDOI 10.18926/AMO/57371
フルテキストURL 73_5_413.pdf
著者 Yanagihara, Yutaka| Nishida, Keigo| Watanabe, Ryuta| Koyama, Kanae| Sawada, Yuichiro| Noda, Terutaka| Asai, Seiji | Fukumoto, Tetsuya| Miura, Noriyoshi| Miyauchi, Yuki| Kikugawa, Tadahiko| Saika, Takashi|
抄録 Laparoscopic radical cystectomy (LRC) is a standard surgical treatment for muscle-invasive bladder cancer and high-risk non-muscle-invasive bladder cancer. LRC is a less invasive modality than conventional open surgery. Therefore, even elderly patients with invasive bladder cancer may be candidates for LRC. In this study, a comparative analysis of perioperative/oncological outcomes between elderly patients and younger patients who underwent LRC was performed to assess the feasibility of LRC in elderly patients. Sixty-eight consecutive patients who underwent LRC between October 2013 and March 2018 were enrolled and stratified into those younger than 75 years (n=37) and those ≥ 75 years old (n=31). The median follow-up period was 28.2 months. The preoperative and operative parameters and complications were similar in both groups. The 2-year overall survival (OS) was 64.4% in the younger vs. 76.4% in the elderly group (p=0.053), cancer-specific survival (CSS) was 79.3% vs. 81.7% (p=0.187), and recurrence-free survival (RFS) was 58.2% vs. 75.7% (p=0.174), respectively. No significant differences were observed in OS, CSS, or RFS between the groups. No significant differences were found between the groups with respect to peri-surgical/oncological outcomes. We conclude that LRC is feasible in elderly patients.
キーワード bladder cancer laparoscopic surgery radical cystectomy elderly patient
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
巻 73巻
号 5号
出版者 Okayama University Medical School
開始ページ 417
終了ページ 418
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649367
Web of Science KeyUT 000491886600006
JaLCDOI 10.18926/AMO/57369
フルテキストURL 73_5_393.pdf
著者 Yi Yi Cho Thein| Win, Myitzu| Thuzara, Moe| Matsumoto, Hiroshi| Yamada, Kiyoshi| Kimata, Yoshihiro| Leung, Michael|
抄録 Although many surgical centers perform microsurgery routinely in developed countries, performing microsurgery is challenging in resource-poor developing countries, such as Myanmar. With the establishment of educational training programs and the assistance of volunteer plastic surgical teams, local plastic surgeons can learn the techniques of microsurgery and apply them clinically. The purpose of this study was to establish baseline data and define the challenges of performing microsurgery in Yangon General Hospital, Myanmar. Sixty-four patients underwent reconstruction with free flaps from January 2015 to January 2018. All clinical records of these cases were assessed. The number of free flap reconstructions performed increased from 11 in the first year to 24 in the third year. The anterolateral thigh flap was the most commonly used (42%). The most common sites of reconstruction were mandible and intraoral defects. Total flap survival occurred in 58 of 64 patients (89%). The total salvageable flap rate for revision surgery was 66.6%; the successful revision rate was highest in 2017, with fewer complications. The flap salvage rates increased and the operative duration decreased as clinical experience improved. Establishing a microsurgical center requires a strong multidisciplinary team, clinical experience, continuous learning, sensible clinical application, and effective interdepartmental and intradepartmental cooperation.
キーワード microsurgery educational programs challenges of microsurgical free flaps reoperation flap salvageable rate
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
巻 73巻
号 5号
出版者 Okayama University Medical School
開始ページ 393
終了ページ 401
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649365
Web of Science KeyUT 000491886600004
JaLCDOI 10.18926/AMO/57368
フルテキストURL 73_5_387.pdf
著者 Inoue, Miyabi| Yokoyama, Teruhiko|
抄録 To assess the efficacy and safety of 2 drugs for overactive bladder (OAB), solifenacin and mirabegron. Fortyseven female OAB patients were randomized into 2 groups. Twenty-three patients were initially prescribed solifenacin for 4 weeks, followed by mirabegron for 4 weeks (group S). The other 24 patients were initially prescribed mirabegron for 4 weeks, followed by solifenacin for 4 weeks (group M). Evaluations included clinical determination of the OAB symptom score (OABSS), International Prostate Symptom Score (IPSS), and Visual Analog Scale. The IPSS significantly improved after the administration of solifenacin in both groups. The OABSS significantly improved in both groups after 4 weeks. In group M, the OABSS after eight weeks was significantly improved compared to that after 4 weeks. However, in group S, it was not significantly improved. Twelve patients experienced adverse events during the solifenacin treatment, while 2 patients experienced adverse events during the mirabegron treatment. Both solifenacin and mirabegron led to improved OAB symptoms. Switching from mirabegron to solifenacin significantly improved the OABSS. However, mirabegron led to fewer adverse events than solifenacin. We recommend that mirabegron be prescribed first for OAB patients. If patients are not satisfied with mirabegron, solifenacin should be used.
キーワード overactive bladder, randomized crossover study solifenacin mirabegron
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
巻 73巻
号 5号
出版者 Okayama University Medical School
開始ページ 387
終了ページ 392
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649364
Web of Science KeyUT 000491886600003
JaLCDOI 10.18926/AMO/57367
フルテキストURL 73_5_383.pdf
著者 Fu, Li| Nishibori, Masahiro|
抄録 High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis.
キーワード HMGB1 epileptogenesis inflammation blood-brain barrier
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2019-10
巻 73巻
号 5号
出版者 Okayama University Medical School
開始ページ 383
終了ページ 386
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649363
Web of Science KeyUT 000491886600002
JaLCDOI 10.18926/AMO/57366
フルテキストURL 73_5_379.pdf
著者 Wake, Hidenori|
抄録 Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.
キーワード htidine-rich glycoprotein septic pathogenesis immunothrombosis
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2019-10
巻 73巻
号 5号
出版者 Okayama University Medical School
開始ページ 379
終了ページ 382
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649362
Web of Science KeyUT 000491886600001
フルテキストURL J_ChemPhys_151_064702_p.pdf
著者 Yagasaki, Takuma| Yamasaki, Masaru| Matsumoto, Masakazu| Tanaka, Hideki|
備考 This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Takuma Yagasaki et. al. Formation of hot ice caused by carbon nanobrushes. The Journal of Chemical Physics 151(6), 064702 (2019)(citation of published article) and may be found at https://doi.org/10.1063/1.5111843.|
発行日 2019-08-08
出版物タイトル The Journal of Chemical Physics
巻 151巻
号 6号
出版者 American Institute of Physics
開始ページ 064702
ISSN 00219606
NCID AA00694991
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 Copyright (2019) Author(s)
論文のバージョン publisher
DOI 10.1063/1.5111843
関連URL isVersionOf https://doi.org/10.1063/1.5111843
フルテキストURL SciRep_9_1_14001_p.pdf
著者 Uchiyama, Hironobu| Sasaki, Ken| Hinosawa, Shogo| Tanaka, Keisuke| Matsumura, Kentarou| Yajima, Shunsuke| Miyatake, Takahisa|
発行日 2019-09-30
出版物タイトル Scientific reports
巻 9巻
号 1号
出版者 Springer Nature
開始ページ 14001
ISSN 20452322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2019
論文のバージョン publisher
PubMed ID 31570743
DOI 10.1038/s41598-019-50440-5
Web of Science KeyUT 000488223900004
関連URL isVersionOf https://doi.org/10.1038/s41598-019-50440-5
フルテキストURL fulltext.pdf
著者 Katayama, Norihisa| Nakamura, Katsumasa| Yorozu, Atsunori| Kikuchi, Takashi| Fukushima, Masanori| Saito, Shiro| Dokiya, Takushi|
キーワード Biochemical failure Brachytherapy External beam radiation therapy Predictive factors Prostate cancer Risk group
発行日 2019-10-31
出版物タイトル Brachytherapy
巻 18巻
号 5号
出版者 Elsevier
開始ページ 574
終了ページ 582
ISSN 15384721
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
論文のバージョン author
PubMed ID 31153759
DOI 10.1016/j.brachy.2019.03.008
Web of Science KeyUT 000487173400002
関連URL isVersionOf https://doi.org/10.1016/j.brachy.2019.03.008
フルテキストURL JDS96_1_26.pdf Fig.pdf
著者 Sugihara, Satoru| Sugimoto, Saeko| Tachibana, Kota| Kobashi, Mina| Nomura, Hayato| Miyake, Tomoko| Hirai, Yoji| Yamasaki, Osamu| Morizane, Shin|
キーワード Epidermal keratinocyte IL-17A Lympho-epithelial Kazal-type inhibitor Serine protease inhibitor TNF-α
発行日 2019-08-21
出版物タイトル Journal of Dermatological Science
巻 96巻
号 1号
出版者 Elsevier
開始ページ 26
終了ページ 32
ISSN 09231811
NCID AA1075636X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31501002
DOI 10.1016/j.jdermsci.2019.08.007
Web of Science KeyUT 000497889600004
関連URL isVersionOf https://doi.org/10.1016/j.jdermsci.2019.08.007
フルテキストURL J_Thorac_Oncol_201907017.pdf
著者 Makimoto, Go| Ohashi, Kadoaki| Tomida, Shuta| Nishii, Kazuya| Matsubara, Takehiro| Kayatani, Hiroe| Higo, Hisao| Ninomiya, Kiichiro| Sato, Akiko| Watanabe, Hiromi| Kano, Hirohisa| Ninomiya, Takashi| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Takata, Minoru| Maeda, Yoshinobu| Kiura, Katsuyuki|
キーワード ALK G1202R Alectinib Amphiregulin MET NSCLC
発行日 2019-07-30
出版物タイトル Journal of Thoracic Oncology
巻 14巻
号 11号
出版者 Elsevier
開始ページ 2009
終了ページ 2018
ISSN 15560864
NCID AA12058455
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
論文のバージョン author
PubMed ID 31374369
DOI 10.1016/j.jtho.2019.07.017
Web of Science KeyUT 000492678300025
関連URL isVersionOf https://doi.org/10.1016/j.jtho.2019.07.017
フルテキストURL fulltext.pdf
著者 Cheng, Hongyang| Shuku, Takayuki| Thoeni, Klaus| Tempone, Pamela| Luding, Stefan| Magnanimo, Vanessa|
キーワード Iterative parameter estimation Sequential Monte Carlo Dirichlet process mixture model Discrete element method X-ray tomography Cyclic oedometric compression
発行日 2019-06-15
出版物タイトル Computer Methods in Applied Mechanics and Engineering
巻 350巻
出版者 Elsevier
開始ページ 268
終了ページ 294
ISSN 0045-7825
NCID AA00613297
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 The Author(s).
論文のバージョン publisher
DOI 10.1016/j.cma.2019.01.027
Web of Science KeyUT 000468163500012
関連URL isVersionOf https://doi.org/10.1016/j.cma.2019.01.027