検索結果 47530 件
| JaLCDOI | 10.18926/AMO/48965 |
|---|---|
| フルテキストURL | 66_5_409.pdf |
| 著者 | Sarai, Takaaki| Inoue, Takayuki| Fujiwara, Kazuo| Kuramoto, Koichi| |
| 抄録 | The human femur is subjected to an impulsive load at its distal end during daily life. Femoral bone fracture caused by impact loading is common in elderly women. It is important to clarify the dynamic response of the femur and to evaluate the change in its stress state during impact loading. A 3-dimensional model of the femur was prepared in the present study, and the impulsive stress waves propagating from the distal end of the femur were analyzed by the dynamic finite element method. This model showed that the von Mises equivalent stress is large on the anterior and posterior sides of the mid-diaphysis when the impact direction is different from that of the bone axis. As for the femoral neck, the absolute value of minimum principal stress initially increases on the medial side;slightly later the maximum principal stress increases on the lateral side. In this case, the absolute value of the maximum principal stress was found to be larger than that of the minimum principal stress, and the absolute value of the principal stress decreased as the impact angle increased. Further, the femoral neck and the trochanter were shown to have a higher risk of bone fracture when the impact direction is coincident with the bone axis. |
| キーワード | biomechanics femur impulsive stress wave impact angle dynamic finite element analysis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-10 |
| 巻 | 66巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 409 |
| 終了ページ | 415 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23093059 |
| Web of Science KeyUT | 000310253900005 |
| JaLCDOI | 10.18926/AMO/48964 |
|---|---|
| フルテキストURL | 66_5_399.pdf |
| 著者 | Jing, Shao-Wu| Wang, Ya-Di| Kuroda, Masahiro| Su, Jing-Wei| Sun, Guo-Gui| Liu, Qing| Cheng, Yun-Jie| Yang, Cong-Rong| |
| 抄録 | Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion and metastasis, but no study has reported its action in esophageal carcinoma. The goal of this study was to explore the probable mechanism of HIF-1α in the invasion and metastasis of esophageal carcinoma Eca109 cells in vitro and in vivo. mRNA and protein expression of HIF-1α, E-cadherin and matrix metalloproteinase-2 (MMP-2) under hypoxia were detected by RT-PCR and Western blotting. The effects of silencing HIF-1α on E-cadherin, MMP-2 mRNA and protein expression under hypoxia or normoxia were detected by RT-PCR and Western blotting, respectively. The invasive ability of Eca109 cells was tested using a transwell chambers. We established an Eca109-implanted tumor model and observed tumor growth and lymph node metastasis. The expression of HIF-1α, E-cadherin and MMP-2 in xenograft tumors was detected by Western blotting. After exposure to hypoxia, HIF-1α protein was up-regulated, both mRNA and protein levels of E-cadherin were down-regulated and MMP-2 was up-regulated, while HIF-1α mRNA showed no significant change. SiRNA could block HIF-1α effectively, increase E-cadherin expression and inhibit MMP-2 expression. The number of invading cells decreased after HIF-1α was silenced. Meanwhile, the tumor volume was much smaller, and the metastatic rate of lymph nodes and the positive rate were lower in vivo. Our observations suggest that HIF-1α inhibition might be an effective strategy to weaken invasion and metastasis in the esophageal carcinoma Eca109 cell line. |
| キーワード | hypoxia-inducible factor-1α esophageal carcinoma invasion and metastasis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-10 |
| 巻 | 66巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 399 |
| 終了ページ | 407 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23093058 |
| Web of Science KeyUT | 000310253900004 |
| JaLCDOI | 10.18926/AMO/48963 |
|---|---|
| フルテキストURL | 66_5_387.pdf |
| 著者 | Chikasue, Kumiko| Kimura, Miyuki| Ikeda, Kazuyuki| Ohnishi, Takuma| Kawanishi, Satoshi| Iio, Tomoe| Kataoka, Mikio| Arao, Yujiro| |
| 抄録 | To determine whether exhaled breath contains Torque teno virus (TTV) or not, we tested exhaled breath condensate (EBC) samples by semi-nested PCR assay. We detected TTV DNA in 35% (7/20) of EBC samples collected from the mouth of one of the authors, demonstrating that TTV DNA is excreted in exhaled breath with moderate frequency. TTV DNA was detected also in oral EBC samples from 4 of 6 other authors, indicating that TTV DNA excretion in exhaled breath is not an exception but rather a common phenomenon. Furthermore, the same assay could amplify TTV DNA from room air condensate (RAC) samples collected at distances of 20 and 40cm from a human face with 40 (8/20) and 35% (7/20) positive rates, respectively. TTV transmission has been reported to occur during infancy. These distances seem equivalent to that between an infant and its household members while caring for the infant. Taken together, it seems that exhaled breath is one of the possible transmission routes of TTV. We also detected TTV DNA in 25% (10/40) of RAC samples collected at a distance of more than 180cm from any human face, suggesting the risk of airborne infection with TTV in a room. |
| キーワード | Torque teno virus exhaled breath airborne infection polymerase chain reaction |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-10 |
| 巻 | 66巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 387 |
| 終了ページ | 397 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23093057 |
| Web of Science KeyUT | 000310253900003 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/49508 |
| JaLCDOI | 10.18926/AMO/48962 |
|---|---|
| フルテキストURL | 66_6_429.pdf |
| 著者 | Wang, Feifei| Maeda, Nagamasa| Yasuhara, Takao| Kameda, Masahiro| Tsuru, Emi| Yamashita, Tatsuyuki| Shen, Yuan| Tsuda, Masayuki| Date, Isao| Sagara, Yusuke| |
| 抄録 | Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke. |
| キーワード | umbilical cord blood cell transplantation neonatal hypoxic-ischemic brain injury ischemic stroke stem cells |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 429 |
| 終了ページ | 434 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254576 |
| Web of Science KeyUT | 000312966100001 |
| JaLCDOI | 10.18926/AMO/48961 |
|---|---|
| フルテキストURL | 66_5_369.pdf |
| 著者 | Akiyama, Mari| Kobayashi, Katsuhiro| Ohtsuka, Yoko| |
| 抄録 | Dravet syndrome (DS), or severe myoclonic epilepsy in infancy, is one of the most severe types of genetic epilepsy. It is characterized by the initial occurrence of febrile or afebrile seizures that often evolve into status epilepticus in infants with normal development, and by the subsequent appearance of myoclonic and/or atypical absence seizures as well as complex partial seizures. The key feature that characterizes DS is fever sensitivity, although photosensitivity and pattern-sensitivity are also often seen. The prognosis is unfavorable in most cases. Seizures become drug-resistant and persist, with many patients suffering from motor and cognitive impairment. Mutations of SCN1A, which encodes the voltage-gated sodium channel NaV1.1, are the most frequent genetic cause of this syndrome. SCN1A mutations and/or microchromosomal rearrangements involving SCN1A are detected in about 85% of patients. Mutations of PCDH19 have also been reported in female patients with clinical findings compatible with DS. PCDH19 mutations might account for 5% of overall DS cases. Thirty years after its first description, DS is considered as a model of channelopathy. This survey reviews recent developments in the research literature on DS, focusing on the clinical course, as well as its genetic causes. |
| キーワード | Dravet syndrome long-term outcome SCN1A PCDH19 |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-10 |
| 巻 | 66巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 369 |
| 終了ページ | 376 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23093055 |
| Web of Science KeyUT | 000310253900001 |
| 著者 | Takahashi, Kazuo H.| Okada, Yasukazu| Teramura, Kouhei| |
|---|---|
| 発行日 | 2011-08 |
| 出版物タイトル | Journal of Heredity |
| 巻 | 102巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Tsujino, Masahiro| Takahashi, Kazuo H.| |
|---|---|
| 発行日 | 2012-01-01 |
| 出版物タイトル | Ecological Research |
| 巻 | 27巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Nohara, Minoru| Kakiya, Satomi| Kudo, Kazutaka| Oshiro, Yoshihiro| Araki, Shingo| Kobayashi, Tatsuo C.| Oku, Kenta| Nishibori, Eiji| Sawa, Hiroshi| |
|---|---|
| 発行日 | 2012-04 |
| 出版物タイトル | Solid State Communications |
| 巻 | 152巻 |
| 号 | 8号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Nishikubo, Yoshihiro| Nakano, Seiya| Kudo, Kazutaka| Nohara, Minoru| |
|---|---|
| 発行日 | 2012-06-19 |
| 出版物タイトル | Applied Physics Letters |
| 巻 | 100巻 |
| 号 | 25号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Nishioka, Yasutaka| Suzumori, Koichi| Kanda, Takefumi| Wakimoto, Shuichi| |
|---|---|
| 発行日 | 2010-12 |
| 出版物タイトル | Sensors and Actuators A: Physical |
| 巻 | 164巻 |
| 号 | 1-2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Nagase, Jun-ya| Wakimoto, Shuichi| Satoh, Toshiyuki| Saga, Norihiko| Suzumori, Koichi| |
|---|---|
| 発行日 | 2011-10 |
| 出版物タイトル | Smart Materials and Structures |
| 巻 | 20巻 |
| 号 | 10号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 永瀬 純也| 脇元 修一| 嵯峨 宣彦| 鈴森 康一| |
|---|---|
| 発行日 | 2011-09-05 |
| 出版物タイトル | 設計工学 |
| 巻 | 46巻 |
| 号 | 9号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 脇元 修一| 尾崎 健| 鈴森 康一| |
|---|---|
| 発行日 | 2011-09-15 |
| 出版物タイトル | 日本ロボット学会誌 |
| 巻 | 29巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Wakimoto, Shuichi| Suzumori, Koichi| Ogura, Keiko| |
|---|---|
| 発行日 | 2011 |
| 出版物タイトル | Advanced Robotics |
| 巻 | 25巻 |
| 号 | 9-10号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Faudzi, Ahmad 'Athif Mohd| Suzumori, Koichi| Wakimoto, Shuichi| |
|---|---|
| 発行日 | 2010 |
| 出版物タイトル | Advanced Robotics |
| 巻 | 24巻 |
| 号 | 10号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 曽我 賢彦| |
|---|---|
| 発行日 | 2011-12 |
| 出版物タイトル | 日本口腔リハビリテーション学会雑誌 |
| 巻 | 24巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| タイトル（別表記） | A Few Reflections on Power －To Improve its Definitional Utility－ |
|---|---|
| フルテキストURL | olj_034_3_001_030.pdf |
| 著者 | 谷 聖美| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 1985-01-20 |
| 巻 | 34巻 |
| 号 | 3号 |
| 開始ページ | 1 |
| 終了ページ | 30 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40000325443 |
| タイトル（別表記） | Reflection on Policy-Making Theories(1) |
|---|---|
| フルテキストURL | olj_030_4_001_039.pdf |
| 著者 | 谷 聖美| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 1981-03-24 |
| 巻 | 30巻 |
| 号 | 4号 |
| 開始ページ | 1 |
| 終了ページ | 39 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40000325384 |
| タイトル（別表記） | Local Self-Government in U. S. S. R. －A preliminary study－ |
|---|---|
| フルテキストURL | olj_031_2_051_088.pdf |
| 著者 | 谷 聖美| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 1981-11-30 |
| 巻 | 31巻 |
| 号 | 2号 |
| 開始ページ | 51 |
| 終了ページ | 88 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40000325392 |
| タイトル（別表記） | Carlo Lavagna，Costituzione e socialismo, Universale Paperbacks il Mulino．1977 |
|---|---|
| フルテキストURL | olj_032_1_193_207.pdf |
| 著者 | 井口 文男| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 1982-07-31 |
| 巻 | 32巻 |
| 号 | 1号 |
| 開始ページ | 193 |
| 終了ページ | 207 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40000325407 |