検索結果 - 岡山大学学術成果リポジトリ

Locally Advanced Rectal Cancer Invading the Gluteus Maximus Muscle Completely Responded to Total Neoadjuvant Therapy

JaLCDOI	10.18926/AMO/65152
フルテキストURL	77_2_209.pdf
著者	Sakamoto, Masaki\| Teraishi, Fuminori\| Shigeyasu Kunitoshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
抄録	A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival.
キーワード	locally advanced rectal cancer total neoadjuvant therapy lateral vastus lateral great muscle flap
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2023-04
巻	77巻
号	2号
出版者	Okayama University Medical School
開始ページ	209
終了ページ	213
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37094960
Web of Science KeyUT	000982563800003

Comparison of serum sIL-2R and LDH levels in patients with intravascular large B-cell lymphoma and patients with advanced stage diffuse large B-cell lymphoma

フルテキストURL	fulltext.pdf
著者	Hirami, Yuki\| Nishimura, Midori Filiz\| Urata, Tomohiro\| Morimoto, Michiko\| Maekawa, Yukina\| Yoshino, Tadashi\| Nishimura, Yoshito\| Sato, Yasuharu\|
キーワード	intravascular large B-cell lymphoma diffuse large B-cell lymphoma soluble interleukin-2 receptor lactate dehy-drogenase B symptoms
発行日	2023
出版物タイトル	Journal of Clinical and Experimental Hematopathology
巻	63巻
号	1号
出版者	Japanese Society for Lymphoreticular Tissue Research
開始ページ	25
終了ページ	31
ISSN	1346-4280
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン	publisher
PubMed ID	36843068
DOI	10.3960/jslrt.22043
Web of Science KeyUT	000937326000001
関連URL	isVersionOf https://doi.org/10.3960/jslrt.22043

Chloride ions evoke taste sensations by binding to the extracellular ligand-binding domain of sweet/umami taste receptors

フルテキストURL	fulltext.pdf
著者	Atsumi, Nanako\| Yasumatsu, Keiko\| Takashina, Yuriko\| Ito, Chiaki\| Yasui, Norihisa\| Margolskee, Robert F.\| Yamashita, Atsuko\|
キーワード	taste receptor salt taste chloride O latipes Mouse Other
発行日	2023-02-28
出版物タイトル	eLife
巻	12巻
出版者	eLife Sciences Publications Ltd.
開始ページ	e84291
ISSN	2050-084X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Atsumi, Yasumatsu et al.
論文のバージョン	publisher
PubMed ID	36852482
DOI	10.7554/eLife.84291
Web of Science KeyUT	000941610100001
関連URL	isVersionOf https://doi.org/10.7554/eLife.84291

A Study of Sustainable Management in Arts and Cultural Activities

フルテキストURL	11_setouchi_project_en.pdf
著者	Nishita, Yosuke\|
発行日	2023-03
出版物タイトル	Setouchi Sustainability and Well-being Research Project Final Report
資料タイプ	研究報告書
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher

Therapeutic Strategies to Overcome Fibrotic Barriers to Nanomedicine in the Pancreatic Tumor Microenvironment

フルテキストURL	fulltext.pdf
著者	Tanaka, Hiroyoshi Y.\| Nakazawa, Takuya\| Enomoto, Atsushi\| Masamune, Atsushi\| Kano, Mitsunobu R.\|
キーワード	pancreatic cancer tumor microenvironment nanomedicine fibrosis extracellular matrix fibroblast
発行日	2023-01-24
出版物タイトル	Cancers
巻	15巻
号	3号
出版者	MDPI
開始ページ	724
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	36765684
DOI	10.3390/cancers15030724
Web of Science KeyUT	000929314700001
関連URL	isVersionOf https://doi.org/10.3390/cancers15030724

The Pursuit of the "Inside" of the Amyloid Hypothesis-Is C99 a Promising Therapeutic Target for Alzheimer's Disease?

フルテキストURL	fulltext.pdf
著者	Takasugi, Nobumasa\| Komai, Masato\| Kaneshiro, Nanaka\| Ikeda, Atsuya\| Kamikubo, Yuji\| Uehara, Takashi\|
キーワード	Alzheimer's disease amyloid-beta amyloid beta precursor protein BACE1 C99 endolysosome autolysosome vesicular trafficking
発行日	2023-01-31
出版物タイトル	Cells
巻	12巻
号	3号
出版者	MDPI
開始ページ	454
ISSN	2073-4409
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	36766796
DOI	10.3390/cells12030454
Web of Science KeyUT	000931442200001
関連URL	isVersionOf https://doi.org/10.3390/cells12030454

Analysis of Phase Angle and Balance and Gait Functions in Pre-Frail Individuals: A Cross-Sectional Observational Study

JaLCDOI	10.18926/AMO/64357
フルテキストURL	77_1_21.pdf
著者	Homma, Daisuke\| Minato, Izumi\| Imai, Norio\| Miyasaka, Dai\| Sakai, Yoshinori\| Horigome, Yoji\| Suzuki, Hayato\| Dohmae, Yoichiro\| Endo, Naoto\|
抄録	We measured the muscle mass and phase angle of each body part to evaluate the relationship between balance and gait functions in individuals with a pre-frailty status. This cross-sectional observational study determined the skeletal muscle mass-to-body weight ratio and phase angles of 21 control (robust) and 29 pre-frail subjects. Their Brief-Balance Evaluation Systems Test, Timed Up-and-Go (TUG) test, Life-Space Assessment, and Modified Fall Efficacy Scale scores plus the relationship between muscle mass, phase angle, and motor function were evaluated. In the pre-frailty group (three males, 26 females, aged 75.58±7.60 years), significant correlations were noted between the Brief-Balance Evaluation Systems Test score and lower-limb (r=0.614) and wholebody (r=0.557) phase angles, and between the TUG test score and lower-limb muscle mass-to-body weight ratio (r=−0.616), lower-limb phase angle (r=−0.616), and whole-body phase angle (r=−0.527). Evaluating the phase angle of the lower extremities of pre-frail patients and intervening accordingly may help clinicians maintain and improve these patients’ balance and gait functions.
キーワード	bioelectrical impedance analysis motor function muscle quality muscle volume
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-02
巻	77巻
号	1号
出版者	Okayama University Medical School
開始ページ	21
終了ページ	27
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36849142
Web of Science KeyUT	000953663800003

鳥類におけるアルギニンバソトシン神経の性差

タイトル（別表記）	Sexual Dimorphism of Arginine Vasotocin Neuron in Birds
フルテキストURL	srfa_112_019_022.pdf
著者	齋藤昇\|
抄録	Arginine vasotocin (AVT) is one of neurohypophysial peptides in birds and is well known both as an antidiuretic and oxytocic hormone. AVT is produced in the hypothalamus and mainly synthesized in magnocellular neurons, supraoptic nucleus (SON) and paraventricular nucleus (PVN). Recent, immunocytochemistry and in situ hybridization results indicate that AVT is also synthesized in parvocellular neurons corresponding to mammalian stria terminalis (nST). The AVT neurons in nST in the male are more numerous than those in the female. Therefore, these data suggest that there is sexual dimorphism in the distribution of AVT neurons. Several experiments involving electrical lesion, testosterone implantation, and the detection of the immediately-early gene expression in birds expressing copulatory behavior suggested that nST and nucleus praeopticus medialis (POM) were related to the reproductive behavior. When male embryo was treated with estradiol, the distribution of AVT neurons assumes the same distribution as found in the female, and reproductive behavior was abolished, suggesting that AVT in the brain has an important role in reproductive behavior.
キーワード	arginine vasotocin sexual dimorphism reproductive behavior parvocellular neurons bird
出版物タイトル	岡山大学農学部学術報告
発行日	2023-02-01
巻	112巻
開始ページ	19
終了ページ	22
ISSN	2186-7755
言語	日本語
論文のバージョン	publisher

Crystal structures of photosystem II from a cyanobacterium expressing psbA2 in comparison to psbA3 reveal differences in the D1 subunit

フルテキストURL	fulltext.pdf
著者	Nakajima, Yoshiki\| Ugai-Amo, Natsumi\| Tone, Naoki\| Nakagawa, Akiko\| Iwai, Masako\| Ikeuchi, Masahiko\| Sugiura, Miwa\| Suga, Michihiro\| Jian-Ren, Shen\|
発行日	2022-12
出版物タイトル	Journal Of Biological Chemistry
巻	298巻
号	12号
出版者	Elsevier
開始ページ	102668
ISSN	1083-351X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 THE AUTHORS.
論文のバージョン	publisher
PubMed ID	36334624
DOI	10.1016/j.jbc.2022.102668
Web of Science KeyUT	000897992300012
関連URL	isVersionOf https://doi.org/10.1016/j.jbc.2022.102668

Impact of number of functional teeth on independence of Japanese older adults

フルテキストURL	fulltext20221223-2.pdf
著者	Maekawa, Kenji\| Ikeuchi, Tomoko\| Shinkai, Shoji\| Hirano, Hirohiko\| Ryu, Masahiro\| Tamaki, Katsushi\| Yatani, Hirofumi\| Kuboki, Takuo\| Kimura‐Ono, Aya\| Kikutani, Takeshi\| Suganuma, Takashi\| Ayukawa, Yasunori\| Gonda, Tomoya\| Ogawa, Toru\| Fujisawa, Masanori\| Ishigaki, Shoichi\| Watanabe, Yutaka\| Kitamura, Akihiko\| Taniguchi, Yu\| Fujiwara, Yoshinori\| Edahiro, Ayako\| Ohara, Yuki\| Furuya, Junichi\| Nakajima, Junko\| Umeki, Kento\| Igarashi, Kentaro\| Horibe, Yasuhiro\| Kugimiya, Yoshihiro\| Kawai, Yasuhiko\| Matsumura, Hideo\| Ichikawa, Tetsuo\| Ohkawa, Shuji\| Baba, Kazuyoshi\| Kusatsu ISLE Study Working Group Collaborators\|
キーワード	community-dwelling older adults functional teeth loss of independence oral health present teeth
発行日	2022-11-21
出版物タイトル	Geriatrics
巻	22巻
号	12号
出版者	Wiley
開始ページ	1032
終了ページ	1039
ISSN	1444-1586
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
PubMed ID	36408675
DOI	10.1111/ggi.14508
Web of Science KeyUT	000888381800001

Clinical implications and optimal extent of lymphadenectomy for intrahepatic cholangiocarcinoma: A multicenter analysis of the therapeutic index

フルテキストURL	fulltext.pdf
著者	Umeda, Yuzo\| Takagi, Kosei\| Matsuda, Tatsuo\| Fuji, Tomokazu\| Kojima, Toru\| Satoh, Daisuke\| Hioki, Masayoshi\| Endo, Yoshikatsu\| Inagaki, Masaru\| Oishi, Masahiro\| Yagi, Takahito\| Fujiwara, Toshiyoshi\|
キーワード	intrahepatic cholangiocarcinoma lymphadenectomy multicenter study retrospective study
発行日	2022-11-27
出版物タイトル	Annals Of Gastroenterological Surgery
出版者	Wiley
ISSN	2475-0328
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
DOI	10.1002/ags3.12642
Web of Science KeyUT	000891179400001
関連URL	isVersionOf https://doi.org/10.1002/ags3.12642

Are Prophylactic Systemic Antibiotics Required in Patients with Cataract Surgery at Local Anesthesia?

フルテキストURL	fulltext20221130-1.pdf
著者	Matsuo, Toshihiko\| Iguchi, Masahiro\| Morisato, Noriyasu\| Murasako, Tatsuya\| Hagiya, Hideharu\|
キーワード	cataract surgery global action plan antimicrobial resistance appropriate use antibiotics oral intravenous topical povidone iodine conjunctival sac culture
発行日	2022-11-27
出版物タイトル	International Journal of Environmental Research and Public Health
巻	19巻
号	23号
出版者	MDPI AG
開始ページ	15796
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
DOI	10.3390/ijerph192315796

Late‐onset familial Diamond–Blackfan anemia with neutropenia caused by RPL35A variant

フルテキストURL	fulltext20221124-1.pdf DBA_Figure1_20220614_400.jpg
著者	Tamefusa, Kosuke\| Muraoka, Michiko\| Washio, Kana\| Wakamatsu, Manabu\| Shimada, Akira\|
キーワード	Diamond-Blackfan anemia neutropenia next-generation sequencing RPL35A variant
備考	This is the peer reviewed version of the following article: [Tamefusa, K., Muraoka, M., Washio, K., Wakamatsu, M. and Shimada, A. (2022), Late-onset familial Diamond–Blackfan anemia with neutropenia caused by RPL35A variant. Pediatrics International, 64: e15275.], which has been published in final form at [https://doi.org/10.1111/ped.15275]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This is the Accepted Manuscript. This full-text does not reflect post-acceptance improvements, or any corrections. この論文は著者最終稿版です。受理後の校正・修正を反映していないため、表現が最終版と異なる箇所があります。\| This full-text will be available in Oct. 2023.\|
発行日	2022-10-18
出版物タイトル	Pediatrics International
巻	64巻
号	1号
出版者	Wiley
開始ページ	e15275
ISSN	1328-8067
NCID	AA11320483
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Japan Pediatric Society.
論文のバージョン	author
PubMed ID	36257617
DOI	10.1111/ped.15275
Web of Science KeyUT	000869400500001
関連URL	isVersionOf https://doi.org/10.1111/ped.15275

Footedness for scratching itchy eyes in rodents

フルテキストURL	fulltext20221117-1.pdf
著者	Katayama, Yukitoshi\| Miura, Ayane\| Sakamoto, Tatsuya\| Takanami, Keiko\| Sakamoto, Hirotaka\|
キーワード	itchy eyes histamine gastrin-releasing peptide receptor footedness
発行日	2022-10-19
出版物タイトル	Proceedings of the Royal Society B: Biological Sciences
巻	289巻
号	1985号
出版者	The Royal Society
開始ページ	20221126
ISSN	0962-8452
NCID	AA00786976
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Author(s)
論文のバージョン	author
PubMed ID	36259204
DOI	10.1098/rspb.2022.1126
Web of Science KeyUT	000872392900003
関連URL	isVersionOf https://doi.org/10.1098/rspb.2022.1126

History of Transcatheter Arterial Chemoembolization Predicts the Efficacy of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients

JaLCDOI	10.18926/AMO/64120
フルテキストURL	76_6_695.pdf
著者	Onishi, Hideki\| Nouso, Kazuhiro\| Takaki, Akinobu\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Takeuchi, Yasuto\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC.
キーワード	hepatic arterial infusion chemotherapy hepatocellular carcinoma refractory transcatheter arterial chemoembolization
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	695
終了ページ	703
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549772
Web of Science KeyUT	000905195100010

Efficacy and Safety of Three-dimensional Conformal Radiotherapy for Macroscopic Vascular Invasion of Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/64118
フルテキストURL	76_6_679.pdf
著者	Asagi, Akinori\| Sakaguchi, Chihiro\| Nadano, Seijin\| Nishina, Tomohiro\| Hamamoto, Yasushi\| Kataoka, Masaaki\| Yamashita, Natsumi\| Tanimizu, Masahito\| Hyodo, Ichinosuke\|
抄録	Chemotherapy is insufficient to treat macroscopic vascular invasion (MVI) of hepatocellular carcinoma (HCC). We retrospectively investigated the treatment outcomes of patients who underwent three-dimensional conformal radiotherapy (3D-CRT) for HCC MVI and analyzed prognostic factors by multivariate analysis using a Cox proportional hazard model. Sixty-five patients were studied. MVI sites were the portal vein (n=48 patients), portal and hepatic veins (n=8), and hepatic vein (n=9). The median irradiation dose was 50 Gy. The median survival time (MST) was 7.5 months. Performance status 2 or 3, modified albumin-bilirubin grade 2b or 3, and massive/diffuse type were poor prognostic factors. Nineteen patients (29%) with a treatment effect of 3 or 4 (≥ 50% of tumor necrosis or regression) at the irradiation sites according to the Response Evaluation Criteria in Cancer of the Liver showed longer survival than those with an effect of 1 or 2 (MST 18.7 vs. 5.9 months, p<0.001). No treatment-related death occurred. The hepatic function reserve was preserved in more than 70% of patients. 3D-CRT controlled HCC MVI safely and was suggested to be a good treatment option.
キーワード	hepatocellular carcinoma macroscopic vascular invasion portal vein tumor thrombosis hepatic vein tumor thrombosis three-dimensional conformal radiotherapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-12
巻	76巻
号	6号
出版者	Okayama University Medical School
開始ページ	679
終了ページ	688
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36549770
Web of Science KeyUT	000905195100008

Physiological and Psychological Effectiveness of Facial Massage in Women : A Randomized Crossover Trial

フルテキストURL	O0004545_abstract_review.pdf O0004545_fulltext.pdf
著者	大川百合子\|
発行日	2022-09-22
資料タイプ	学位論文
学位授与番号	乙第4545号
学位授与年月日	2022-09-22
学位・専攻分野	博士（看護学）
授与大学	岡山大学
言語	英語
著作権者	© 2023 Japan Society of Nursing Research

Diverse roles of a siderophore in a plant-growth promoting methylotroph, Methylobacterium aquaticum strain 22A

フルテキストURL	K0006731_abstract_review.pdf K0006731_fulltext.pdf
著者	PATRICK OTIENO JUMA\|
発行日	2022-09-22
資料タイプ	学位論文
学位授与番号	甲第6731号
学位授与年月日	2022-09-22
学位・専攻分野	博士（農学）
授与大学	岡山大学
言語	英語

Stromal cells in the tumor microenvironment promote the progression of oral squamous cell carcinoma

フルテキストURL	K0006710_abstract_review.pdf K0006710_fulltext.pdf K0006710_summary.pdf
著者	Shan, Qiusheng\|
発行日	2022-09-22
資料タイプ	学位論文
学位授与番号	甲第6710号
学位授与年月日	2022-09-22
学位・専攻分野	博士（歯学）
授与大学	岡山大学
言語	英語
著作権者	© Shan et al.

Meta-Analysis-Assisted Detection of Gravity-Sensitive Genes in Human Vascular Endothelial Cells

フルテキストURL	K0006704_abstract_review.pdf K0006704_fulltext.pdf K0006704_summary.pdf
著者	梁茵\|
発行日	2022-09-22
資料タイプ	学位論文
学位授与番号	甲第6704号
学位授与年月日	2022-09-22
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	Copyright © 2021 Liang, Wang, Liu, Wang, Takahashi and Naruse.