On the action of some drugs upon the arterioles and capillaries

1. Direct application of the mustard-oil to the web, mesentery and bladder wall of frog, caused remarkable dilatation both on the arterioles and capillaries. And capillaries are dilated independently of variation in the arterial blood pressure. 2. A solution of guanidin stronger than 5.0 p. c. has constricting effect upon the arterioles and capillaries, while weak solution (1.0-4.0 p. c.) causes dilatation of the arterioles and capillaries. 3. Adrenalin has contractive effect upon the arterioles but it shows, on the other hand, dilatation of capillaries indepent of variation in the arterial blood pressure. 4. Pituitrin causes contraction of the arterioles, on the contrary, capillaries are always dilated. Its contractive (upon the arterioles) and dilator effect (upon the capillaries) are weaker than that produced with adrenalin. 5. Caffein shows dilator effect both on the arterioles and capillaries. The dilatation of capillaries is independent of variation in the arterial blood pressure. 6. Isotonic solution (with 0.65 p. c. NaCL) of NaNo3, NaNO2 and Na2HPO4 causes slight dilatation of the arterioles and capillaries, while kalium salts (t. i. KCLO, KNO3, KBr etc.) contraction. Calcium salts and magnecium salts have dilator effect both on the arterioles and capillaries. Some organic substances which have reducing ability, have dilator effect upon the arterioles and capillaries.

毛細血管ノ運動(收縮竝ニ擴大)ハ受働的ニシテ夫レト相連續セル小動脉ノ收縮或ハ擴大ノ状態ニヨリテ左右セラレ小動脉ノ擴大ハ毛細血管ニ於ケル壓ノ上昇ヲ來タシタメニ該毛細血管ハ受働的ニ擴大ヲ來タシ壓ノ下降ニ際シテ自身ノ彈力ニヨリテ元ニ復ス事ハ一般ニ信ゼラルル事實ナリ. 然ルニ又一方ニ於テ毛細血管ノ運動ハ單ニ壓ニノミ依ル受働的ノモノニ非ズシテ自働的ニ收縮及ビ擴大ヲ起スト云フ多クノ事實ガ認メラレ其後諸種藥劑ニ依リテ毛細血管ガ血壓ニ關係ナク反應ヲ起ス事實ヲ知ルニ至レリ.又近時或藥品ニ對シテ小動脉及ビ毛細血管ガ反對ノ作用ヲ現ハス事ヲ發見セリ例ヘバAdrenalinハ小動脉ニ對シ收縮性ニ働ラクモ毛細血管ハ之ニ反シ擴大ヲ起ス又Histaminハ小動脉ヲ擴大セシムルモ毛細血管ニハ何等ノ影響ヲ及ボサズ. 予ハ五六ノ藥劑ヲ用ヒテ小動脉竝ニ毛細血管ニ對シ果シテ如何ナル作用ヲ及ボスカヲ見ント欲シ次ノ實驗ヲ行ヘリ即チ蛙ノ蹼膜,腸間膜竝ニ膀胱壁ノ小動脉及ビ毛細血管ヲ顯微鏡下ニ觀察シナガラ各藥劑各種溶液ヲ滴下シ小動脉及ビ毛細管ノ變化ヲ見タリ而シテ次ノ成績ヲ得タリ. 1.芥子油ハ小動脉及ビ毛細血管ヲ共ニ著シク擴大セシム而シテ毛細血管ノ擴大作用ハ血壓ニ無關係ナル事ヲ確カメタリ. 2.「グアニヂン」ニ於テハ0.5%以上ノ濃度ニ於テハ小動脉竝ニ毛細管ヲ共ニ收縮セシムルモ1.0-4.0%ニテハ之ニ反シ擴大作用ヲ有ス. 3.「アドレナリン」ハ小動脉ヲ收縮セシムルモ毛細管ハ反ツテ之ヲ擴大セシム. 4.「ピツイトリン」ハ小動脉ヲ收縮セシメ同時ニ毛細血管ヲ擴大セシム而シテ此作用ハ「アドレナリン」ニ比シ其持續性弱シ. 5.「カフエイン」ハ小動脉竝毛細管ヲ共ニ擴大セシム而シテ毛細管ノ擴大ハ血壓ニ無關係ナリ. 6.「ナトリウム」鹽類ハ概ネ擴大ヲ起スモ「カリウム」鹽類ハ之ヲ收縮セシム「カルチウム」鹽類竝ニ「マグネシウム」鹽類ハ共ニ小動脉竝ニ毛細血管ヲ擴大セシム. 7.「ハイドロキノーン」,「ピロガロール」「フロロガルチン」ハ小動脉竝ニ毛細血管ニ對シ著シキ擴大ヲ起サシム.

原著