検索結果 47817 件
| JaLCDOI | 10.18926/AMO/50409 |
|---|---|
| フルテキストURL | 67_3_165.pdf |
| 著者 | Shien, Tadahiko| Kinoshita, Takayuki| Seki, Kunihiko| Yoshida, Miwa| Hojo, Takashi| Shimizu, Chikako| Taira, Naruto| Doihara, Hiroyoshi| Akashi-Tanaka, Sadako| Tsuda, Hitoshi| Fujiwara, Yasuhiro| |
| 抄録 | While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p＝0.045) and histological grade 3 (p＝0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC. |
| キーワード | breast cancer neoadjuvant chemotherapy predictors |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-06 |
| 巻 | 67巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 165 |
| 終了ページ | 170 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23804139 |
| Web of Science KeyUT | Pretreatment Specimen Predicts |
| JaLCDOI | 10.18926/AMO/50408 |
|---|---|
| フルテキストURL | 67_3_153.pdf |
| 著者 | Yamamoto, Masanao| Fujita, Hirofumi| Katase, Naoki| Inoue, Keiji| Nagatsuka, Hitoshi| Utsumi, Kozo| Sasaki, Junzo| Ohuchi, Hideyo| |
| 抄録 | Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer patients. However, the level of PpIX accumulation in oral cancer is fairly low and insufficient for PDT. Ferrochelatase (FECH) and ATP-binding cassette transporter G2 (ABCG2) are known to regulate PpIX accumulation. In addition, serum enhances PpIX export by ABCG2. We investigated here whether and how inhibitors of FECH and ABCG2 and their combination could improve PpIX accumulation and PDT efficacy in an oral cancer cell line in serum-containing medium. ABCG2 inhibitor and the combination of ABCG2 and FECH inhibitors increased PpIX in the presence of fetal bovine serum (FBS) in an oral cancer cell line. Analysis of ABCG2 gene silencing also revealed the involvement of ABCG2 in the regulation of PpIX accumulation. Inhibitors of FECH and ABCG2, and their combination increased the efficiency of ALA-PDT even in the presence of FBS. ALA-PDT-induced cell death was accompanied by apoptotic events and lipid peroxidation. These results suggest that accumulation of PpIX is determined by the activities of ABCG2 and FECH and that treatment with a combination of their inhibitors improves the efficacy of PDT for oral cancer, especially in the presence of serum. |
| キーワード | 5-aminolevulinic acid protoporphyrin IX oncology photodynamic therapy apoptosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-06 |
| 巻 | 67巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 153 |
| 終了ページ | 164 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23804138 |
| Web of Science KeyUT | 000320747900004 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50681 |
| JaLCDOI | 10.18926/AMO/50407 |
|---|---|
| フルテキストURL | 67_3_145.pdf |
| 著者 | Ishihara, Setsuko| Taira, Naruto| Kawasaki, Kensuke| Ishibe, Youichi| Mizoo, Taeko| Nishiyama, Keiko| Iwamoto, Takayuki| Nogami, Tomohiro| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi| Komoike, Yoshifumi| Sato, Shuhei| Kanazawa, Susumu| |
| 抄録 | A high mammographic breast density is considered to be a risk factor for breast cancer. However, only a small number of studies on the association between breast density and lifestyle have been performed. A cross-sectional study was performed using a survey with 29 questions on life history and lifestyle. The breast density on mammography was classified into 4 categories following the BI-RADS criteria. The subjects were 522 women with no medical history of breast cancer. The mean age was 53.3 years old. On multivariate analysis, only BMI was a significant factor determining breast density in premenopausal women (parameter estimate, －0.403;p value, 0.0005), and the density decreased as BMI rose. In postmenopausal women, BMI (parameter estimate, －0.196;p value, 0.0143) and number of deliveries (parameter estimate, －0.388;p value, 0.0186) were significant factors determining breast density;breast density decreased as BMI and number of deliveries increased. Only BMI and number of deliveries were identified as factors significantly influencing breast density. BMI was inversely correlated with breast density before and after menopause, whereas the influence of number of deliveries on breast density was significant only in postmenopausal women in their 50 and 60s. |
| キーワード | breast cancer mammographic breast density life style body mass index |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-06 |
| 巻 | 67巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 145 |
| 終了ページ | 151 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23804137 |
| Web of Science KeyUT | 000320747900003 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50646 |
| JaLCDOI | 10.18926/AMO/50406 |
|---|---|
| フルテキストURL | 67_3_135.pdf |
| 著者 | Ueno, Hiroshi| Shoshi, Chikafumi| Suemitsu, Shunsuke| Usui, Shinichi| Sujiura, Hiroko| Okamoto, Motoi| |
| 抄録 | In the phenomenon known as cross-modal plasticity, the loss of one sensory system is followed by improved functioning of other intact sensory systems. MRI and functional MRI studies suggested a role of the prefrontal cortex and the temporal lobe in cross-modal plasticity. We used a mouse model to examine the effects of sensory deprivation achieved by whisker trimming and visual deprivation achieved by dark rearing in neonatal mice on the appearance of parvalbumin (PV) neurons and the formation of glutamic acid decarboxylase 67 (GAD67)-positive puncta around pyramidal neurons in the prefrontal cortex and hippocampus. Whisker trimming, but not dark rearing, decreased the density of PV neurons in the hippocampus at postnatal day 28 (P28). In the prefrontal cortex, whisker trimming and dark rearing decreased the density of PV neurons in layer 5/6 (L5/6) at P28 and in L2/3 at P56, respectively, whereas dark rearing increased the density of PV neurons in L5/6 at P56. Whisker trimming decreased the density of GAD67-positive puncta in CA1 of the hippocampus at both P28 and P56 and in L5/6 of the prefrontal cortex at P28. Dark rearing decreased the density of GAD67-positive puncta in CA1 of the hippocampus and in both L2/3 and L5/6 of the prefrontal cortex at P28, and in L2/3 of the prefrontal cortex at P56. These results demonstrate that somatosensory or visual deprivation causes changes in the PV-interneuronal network in the mouse prefrontal cortex and hippocampus. The results also suggest that the alteration of the PV-interneuronal network, especially in the prefrontal cortex, may contribute to cross-modal plasticity. |
| キーワード | sensory deprivation parvalbumin glutamate decarboxylase (GAD67) prefrontal cortex hippocampus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-06 |
| 巻 | 67巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 135 |
| 終了ページ | 143 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23804136 |
| Web of Science KeyUT | 000320747900002 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50870 |
| JaLCDOI | 10.18926/AMO/50405 |
|---|---|
| フルテキストURL | 67_3_129.pdf |
| 著者 | Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi| |
| 抄録 | In recent years, many researchers have emphasized the importance of metabolic syndrome based on its increasing prevalence and its adverse prognosis due to associated chronic vascular complications. Upstream of a cluster of metabolic and vascular disorders is the accumulation of visceral adipose tissue, which plays a central role in the pathophysiology. In the accumulation of adipose tissues, cell cycle regulation is tightly linked to cellular processes such as proliferation, hypertrophy and apoptosis. In addition, various cell cycle abnormalities have also been observed in other tissues, such as kidneys and the cardiovascular system, and they are critically involved in the progression of disease. Here, we discuss cell cycle abnormalities in metabolic syndrome in various tissues. Furthermore, we describe the role of nuclear receptors in cell growth and survival, and glucose and lipid metabolism in the whole body. Therapeutic strategies for modulating various cell cycles in metabolic disorders by targeting nuclear receptors may overcome obesity and its chronic vascular complications in the future. |
| キーワード | nuclear receptor cell cycle metabolic syndrome diabetic nephropathy |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-06 |
| 巻 | 67巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 129 |
| 終了ページ | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23804135 |
| Web of Science KeyUT | 000320747900001 |
| 著者 | 小林 純| |
|---|---|
| 発行日 | 1961-02 |
| 出版物タイトル | 農学研究 |
| 巻 | 48巻 |
| 号 | 2号 |
| 資料タイプ | 紀要論文 |
| 著者 | 井上 忠男| |
|---|---|
| 発行日 | 1961-02 |
| 出版物タイトル | 農学研究 |
| 巻 | 48巻 |
| 号 | 2号 |
| 資料タイプ | 紀要論文 |
| 著者 | 日浦 運治| 部田 英雄| 津島 孝宏| |
|---|---|
| 発行日 | 1961-02 |
| 出版物タイトル | 農学研究 |
| 巻 | 48巻 |
| 号 | 2号 |
| 資料タイプ | 紀要論文 |
| 著者 | 笠原 安夫| |
|---|---|
| 発行日 | 1960-12 |
| 出版物タイトル | 農学研究 |
| 巻 | 48巻 |
| 号 | 1号 |
| 資料タイプ | 紀要論文 |
| 著者 | 岡本 賢一| 小沢 潤二郎| |
|---|---|
| 発行日 | 1960-12 |
| 出版物タイトル | 農学研究 |
| 巻 | 48巻 |
| 号 | 1号 |
| 資料タイプ | 紀要論文 |
| 著者 | 井上 忠男| |
|---|---|
| 発行日 | 1960-12 |
| 出版物タイトル | 農学研究 |
| 巻 | 48巻 |
| 号 | 1号 |
| 資料タイプ | 紀要論文 |
| 著者 | 井上 成信| |
|---|---|
| 発行日 | 1960-03 |
| 出版物タイトル | 農学研究 |
| 巻 | 47巻 |
| 号 | 4号 |
| 資料タイプ | 紀要論文 |
| 著者 | 高橋 隆平| 安田 昭三| |
|---|---|
| 発行日 | 1960-03 |
| 出版物タイトル | 農学研究 |
| 巻 | 47巻 |
| 号 | 4号 |
| 資料タイプ | 紀要論文 |
| 著者 | 河田 和雄| |
|---|---|
| 発行日 | 1960-03 |
| 出版物タイトル | 農学研究 |
| 巻 | 47巻 |
| 号 | 4号 |
| 資料タイプ | 紀要論文 |
| 著者 | 杉山 章平| |
|---|---|
| 発行日 | 1960-03 |
| 出版物タイトル | 農学研究 |
| 巻 | 47巻 |
| 号 | 4号 |
| 資料タイプ | 紀要論文 |
| 著者 | 井上 忠男| 大場 景雄| 高橋 隆平| |
|---|---|
| 発行日 | 1960-01 |
| 出版物タイトル | 農学研究 |
| 巻 | 47巻 |
| 号 | 3号 |
| 資料タイプ | 紀要論文 |
| 著者 | 森次 益三| 小林 純| |
|---|---|
| 発行日 | 1960-01 |
| 出版物タイトル | 農学研究 |
| 巻 | 47巻 |
| 号 | 3号 |
| 資料タイプ | 紀要論文 |
| 著者 | 杉山 章平| 松本 義明| |
|---|---|
| 発行日 | 1959-11 |
| 出版物タイトル | 農学研究 |
| 巻 | 47巻 |
| 号 | 1-2号 |
| 資料タイプ | 紀要論文 |
| 著者 | 笠原 安夫| |
|---|---|
| 発行日 | 1959-11 |
| 出版物タイトル | 農学研究 |
| 巻 | 47巻 |
| 号 | 1-2号 |
| 資料タイプ | 紀要論文 |
| 著者 | 安江 安宣| 河田 和雄| |
|---|---|
| 発行日 | 1959-11 |
| 出版物タイトル | 農学研究 |
| 巻 | 47巻 |
| 号 | 1-2号 |
| 資料タイプ | 紀要論文 |