検索結果 15571 件
| JaLCDOI | 10.18926/OER/14929 |
|---|---|
| フルテキストURL | 40_4_115_125.pdf |
| 著者 | 村井 浄信| |
| 抄録 | In 1993, Menshikov and Zuev introduced ρ−percolation model, in which a path of a graph is ρ−passable in a bond percolation configuration if the concentration of open bonds on it is at least ρ, and concerning this model, they gave four open problems. In this paper, we answer three problems out of them : the first one is whether the ρ−percolation critical probability is equal to the critical probability corresponding to finite/infinite expectation of the number of ρ−connectable vertices from a fixed vertex, the second is whether the 1-p ercolation critical probability is equal to the Bernoulli bond percolation critical probability, and finally the third is whether the probability of the existence of ρ−passable path of length exceeding n starting from a fixed vertex always decays exponentially in the subcritical phase. |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2009-03-10 |
| 巻 | 40巻 |
| 号 | 4号 |
| 開始ページ | 115 |
| 終了ページ | 125 |
| ISSN | 0386-3069 |
| 関連URL | http://www.e.okayama-u.ac.jp/~shiryou/gakkaishi.htm |
| 言語 | 英語 |
| 著作権者 | 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 120002308476 |
| JaLCDOI | 10.18926/14927 |
|---|---|
| タイトル（別表記） | サーモグラフィーによる体表面温度の測定 3.体表面温度の回復率と末消血流量との相関 |
| フルテキストURL | 070_036_042.pdf |
| 著者 | 保崎 泰弘| 高田 真吾| 光延 文裕| 御舩 尚志| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 谷崎 勝朗| 越智 浩二| 辻 孝夫| |
| 抄録 | The body surface peripheral circulation in 12 cases, including 9 patients with diabetes mellitus who were suffering coldness, numbness or pain in their feet, and 3
healthy volunteers was examined using Laser-Doppler blood flowmetry. At the same time, the body surface temperature was estimated by thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio = [Total counts of thermography(Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). The recovery ratio and the blood flow were correlated, r=0.68, p |
| キーワード | サーモグラフィー (thermography) レーザードプラー血流計 (Laser-Doppler blood flowmetry) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 36 |
| 終了ページ | 42 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308240 |
| JaLCDOI | 10.18926/14926 |
|---|---|
| タイトル（別表記） | 気管支喘息症例における気道過敏性と鼻腔･副鼻腔疾患の関係に関する検討 |
| フルテキストURL | 070_028_035.pdf |
| 著者 | 御舩 尚志| 高田 真吾| 岡本 誠| 柘野 浩史| 芦田 耕三| 原田 誠之| 光延 文裕| 保崎 泰弘| 谷崎 勝朗| 原田 実根| |
| 抄録 | Pathological changes of nasosinus occur often in subjects with bronchial asthma. Coexisting nasosinus lesion may affect pathophysiology of lower respiratory tract in asthmatics. The extent of nasal and sinus lesion was quantified in 17 patients with bronchial asthma, and their relationships to atopic status, asthma severity and bronchial hyperresponsiveness were evaluated in this study. Opacification degree of maxillary sinuses and nasal mucosa thickening were quantified using CT scans. The opacification degree was evaluated as (total opacification area)/(total maxillary sinus area). Although the opacification degree of maxillary sinuses in atopic patients showed no significant difference compared with that in non-atopic patients, maximum nasal mucosa thickening in atopic patients had a significant difference compared with that in non-atopic patients (p=0.028). In severe asthmatics, the opacification degree of maxillary sinuses was significantly more prominent compared with those in moderate and mild asthmatics (p=0.0005, p=0.036, respectively). Significantly marked nasal mucosa thickening was recognized in mild asthmatics compared with that in moderate asthmatics (p=0.0462). Regarding bronchial hyperresponsiveness, a significant correlation between Dmin and the opacification degree of maxillary sinuses was observed (rs= -0.551, p=0.0276). Nasal mucosa thickening had no correlation with bronchial hyperresponsiveness. The results suggest that sinusitis may affect bronchial hyperresponsiveness and asthma severity. Treatment of sinusitis may lead to improvement of asthma symptoms. |
| キーワード | 気管支喘息 (bronchial asthma) 副鼻腔炎 (sinusitis) CT所見 (CT findings) 気道過敏性 (hyperresponsiveness) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 28 |
| 終了ページ | 35 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308098 |
| JaLCDOI | 10.18926/14925 |
|---|---|
| タイトル（別表記） | 気管支喘息における胸部HRCT所見の臨床[光延文裕1]的意義 |
| フルテキストURL | 070_017_027.pdf |
| 著者 | 光延 文裕| 御舩 尚志| 芦田 耕三| 保崎 泰弘| 柘野 浩史| 岡本 誠| 原田 誠之| 中井 陸郎| 谷崎 勝朗| |
| 抄録 | The significance of the low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) has not been determined in patients with asthma. We examined the relationship between the percentage of lung area with CT numbers lower than -950HU (% LAA) and the mean CT number in 81 patients with reversible airway obstruction (asthma) and in 22 healthy subjects, as well as the relationship between maximal % LAA and various parameters of pulmonary function, smoking history, disease severity and allergic type in the asthmatic subjects. The mean CT
number was obtained by scans at three anatomic levels, and maximal % LAA was the % LAA which had the largest value of those measured at the three anatomic levels of the lung.
We found that: 1. The mean CT number was closely related to the maximal % LAA of the lungs in all subjects studied (r= -0.916, p |
| キーワード | low attenuation area high resolution computed tomography reversible airway obstruction |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 17 |
| 終了ページ | 27 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308175 |
| JaLCDOI | 10.18926/14922 |
|---|---|
| タイトル（別表記） | Ⅰ型アレルギー反応および副腎皮質ホルモンは気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生に影響をおよぼす |
| フルテキストURL | 070_009_016.pdf |
| 著者 | 谷崎 勝朗| 光延 文裕| 御舩 尚志| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 原田 誠之| 高田 真吾| 越智 浩二| 小出 典男| |
| 抄録 | The generation. of leukotrienes 84 (LT84) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 71 patients with asthma (42 with atopic and 29 with nonatopic asthma) and 23 healthy controls. Of these patients,22 had SDIA (steroid-dependent intractable asthma). 1. The generation of LT84 and LTC4 by leucocytes was significantly more enhanced in patients with atopic, non-SOIA asthma than in healthy subjects, but not in patients with nonatopic asthma. The generation of LT84 and LTC4 in atopic asthma was significantly more decreased in patients with SOIA than in those with non-SOIA. 2. The LTC4 generation was significantly larger in attack stage than in attack-free stage of patients with atopic and nonatopic asthma when they had not SOIA. However, no significant difference was found in LT84 generation between attack and nonattack stages in these patients. 3. In patients with SOIA, no significant differences were observed in the generation of LT84 and LTC4 between attack and nonattack stages. The results suggest that IgE-mediated allergy and asthma attacks enhance and glucocorticoids inhibit the generation of LT84 and LTC4 by leucocytes. |
| キーワード | bronchial asthma LT84 LTC4 IgE-mediated allergy glucocorticoids |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 1999-12 |
| 巻 | 70巻 |
| 開始ページ | 9 |
| 終了ページ | 16 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308654 |
| JaLCDOI | 10.18926/14913 |
|---|---|
| タイトル（別表記） | マトリックスメタロプロテアーゼと膵疾患 |
| フルテキストURL | 071_076_083.pdf |
| 著者 | 横山 元浩| 越智 浩二| 水島 孝明| 一村 光子| 鶴見 哲也| 光延 文裕| 谷崎 勝朗| |
| 抄録 | Matrix metalloproteinases (MMPs) is a family of collagenolytic enzymesand are associated with many pathological conditions. Especially, MMPs have a strong relation with tumor progression and invasion. In this review, we focused on association of MMPs and pancreatic diseases, and a potential treatment of MMPs inhibitors for pancreatic cancer. |
| キーワード | matrix metalloproteinase(MMP) tissue inhibitor of metalloproteinase(TIMP) pancreatic cancer (膵癌) chronic pancreatitis (慢性膵炎) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 76 |
| 終了ページ | 83 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308587 |
| JaLCDOI | 10.18926/14910 |
|---|---|
| タイトル（別表記） | ステロイド依存性気管支喘息症例の病的骨折と皮質骨傷害の検討 |
| フルテキストURL | 071_059_067.pdf |
| 著者 | 柘野 浩史| 後藤 文禮| 中井 睦郎| 岡本 誠| 高田 真吾| 御舩 尚志| 保﨑 泰弘| 光延 文裕| 芦田 耕三| 穐山 恒雄| 辻 孝夫| 谷崎 勝朗| |
| 抄録 | In a previous study, we demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD) and induces development of pathologic fractures in asthmatic patients. To investigate cortical bone porosity due to glucocorticoids, we studied cortical bone volume, BMD, bone strength, and fractures in patients with asthma in this report. A total of 82 postmenopausal asthmatic patients were enrolled in the study. Vertebral fractures were diagnosed via plain spinal radiograms. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD, relative cortical volume, and Strength Strain Index (SSI). Multiple regression analysis, Student's t test, and other statistical analyses were performed. Patients with systemic glucocorticoids therapy had lower cortical BMD, relative cortical volume, SSI, and more number of vertebral fractures than patients without it. Lifetime cumulative dose of glucocorticoids was related to cortical BMD, relative cortical volume, SSI, and the number of vertebral fractures. The cortical volumedensity relationship appeared to remain constant regardless of systemic glucocorticoid administration. The number of vertebral fractures correlated highly with cortical BMD, relative cortical volume, and SSI at the radius. In conclusion, systemic glucocorticoid administration decreases cortical bone density, cortical bone volume, and bone strength. G lucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites. Given that both cortical bone density and volume provide bone strength, cortical bone porosity was seen to contribute to glucocorticoid - induced bone strength loss and fractures. |
| キーワード | glucocorticoid cortical bone pQCT osteoporosis |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 59 |
| 終了ページ | 67 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308222 |
| JaLCDOI | 10.18926/14909 |
|---|---|
| タイトル（別表記） | 脂肪の変化と関連した気管支喘息に対するn－3系脂肪酸食の効果 ― n－6系脂肪酸との比較 |
| フルテキストURL | 071_050_058.pdf |
| 著者 | 岡本 誠| 光延 文裕| 芦田 耕三| 御舩 尚志| 保﨑 泰弘| 柘野 浩史| 高田 真吾| 谷崎 勝朗| 原田 実根| |
| 抄録 | N-3 fatty acids have been reported to be effective for asthma. In the present study, the effects of perilla seed oil (n-3 fatty acids) on asthma were compared with the effects of corn oil (n-6 fatty acids) in terms of pulmonary function, lipometabolism and the generation of leukotriene C4 (LTC4) by leucocytes. A total of 28 asthmatic patients were randomly divided into two groups : Group A patients (15 subjects) consumed perilla seed oil-rich supplementation, while Group B patients (13 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTC4 by leucocytes, respiratory function and the serum levels of lipids were compared between the two groups. The generation of LTC4 by leucocytes decreased significantly in Group A subjects following perilla seed oil-rich supplementation for 2(P < 0.05) and 4 weeks(P < 0.01). A significant difference in the generation of LTC4 was observed between the two groups after different dietary supplementations for 4 weeks (P < 0.05). Significantly increased values for PEF (P < 0.01), FVC (P < 0.05) and FEV1.0 (P < 0.05) were found in Group A subjects following perilla seed oil supplementation for 4 weeks, compared with the initial value prior to supplementation. A significant decrease in the serum level of total cholesterol, LDL-cholesterol and phospholipid was detected in Group A subjects following perilla seed oil supplementation for 4 weeks. The present results suggest that peril la seed oil-rich supplementation is effective in the treatment of asthma in terms of its ability to suppress LTC4 generat ion by leucocytes, and in inducing an improvement in pulmonary function associated with changes in the serum level of lipids. |
| キーワード | perilla seed oil (エゴマ抽) a -1inolenic acid (α－リノレン酸) leukotriene C4 (ロイコトリエンC4) respiratory function (呼吸機能) 脂質代謝 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 50 |
| 終了ページ | 58 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308088 |
| JaLCDOI | 10.18926/14907 |
|---|---|
| タイトル（別表記） | 気管支喘息症例における末梢血白血球のロイコトリエンC4産生能とロイコトリエン受容体括抗薬プランルカストの効果に関する検討 |
| フルテキストURL | 071_036_041.pdf |
| 著者 | 御舩 尚志| 高田 真吾| 岡本 誠| 柘野 浩史| 芦田 耕三| 光延 文裕| 保﨑 泰弘| 谷崎 勝朗| 原田 実根| |
| 抄録 | The correlation between the efficacy of 4-weeks administration with pranlukast, leukotriene receptor antagonist, and LTs generation by peripheral leukocytes were evaluated in 18 patients with mild-persistent asthma. The efficacy of pranlukast administration was assessed by symptom, morning PEF and pulmonary function. Pranlukast were effective in 12/18(67%) patients. In those patients, LTC4 generation before pranlukast administration was significantly high, compared with that in pranlukast-ineffective patients. LTC4 generation decreased after 4-weeks administration with pranlukast in effective patients. In ineffective patients, however, LTC4 generation increased after 4-weeks administration. LTB4 had shown no significant difference between effective and ineffective patients before administration, and LTB4 decreased after 4-weeks in both groups. Proport ion of peripheral eosinophi Is in effective patients were higher than that in ineffective patients, however not significant. After 4-weeks, proportion of eosinophi Is was decreased in effective patients and increased in ineffective patients. These findings suggest that pranlukast is effective for patients with high LTC4 generation and has the effect to suppress the accumulation of eosinophils in such patients. |
| キーワード | bronchial asthma pranlukast leukotriene receptor antagonist LTC4 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 36 |
| 終了ページ | 41 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308269 |
| JaLCDOI | 10.18926/14906 |
|---|---|
| タイトル（別表記） | 気管支喘息患者における肺機能とHRCT上のlow attenuation areaに対する喫煙の影響 |
| フルテキストURL | 071_029_035.pdf |
| 著者 | 光延 文裕| 御舩 尚志| 保﨑 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 高田 真吾| 横井 正| 谷崎 勝朗| |
| 抄録 | The influence of smoking on pulmonary function and emphysematous changes of the lung (percentage of attenuation area < -950 HU (% LAA) on high resolution computed tomography (HRCT) was examined in 49 patients with bronchial asthma. 1. In patients with asthma, the % residual volume (RV) in many nonsmokers was less than 129%, in contrast, the % RV in many smokers was between 130% and 189% , which was higher than that in nonsmokers. 2. Significant correlations between % RV and 96LAA value, and between % RV and CT number were observed both in nonsmokers and smokers with asthma, in which as % RV more increased, % LAA value was larger, and CT number was lower. 3. % DLco value was lower in smoking patients with asthma, whose % RV was between 130% and 189% and larger than 190% , however, the % DLco value did not change in nonsmoking patients despite of higher valure in % RV. 4. A significant correlation was also observed between % FEV1.0 value and % RV both in smoking and nonsmoking patients with asthma; as % RV value more increased, % FEV1.0 value was lower. 5. Any correlation between % FVC value and % RV was not observed. These results suggest that smoking affects the % LAA of the lung on HRCT and % DLco in patients with asthma. |
| キーワード | asthma smoking % LAA of the lungs FEV1.0 DLco |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 29 |
| 終了ページ | 35 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308294 |
| JaLCDOI | 10.18926/14905 |
|---|---|
| タイトル（別表記） | 胸部高分解能CT（HRCT）による肺野low attenuation area（LAA）の定量的評価 ―気管支喘息および肺気腫症例の比較検討― |
| フルテキストURL | 071_019_028.pdf |
| 著者 | 光延 文裕| 御舩 尚志| 芦田 耕三| 保﨑 泰弘| 柘野 浩史| 岡本 誠| 原田 誠之| 中井 睦郎| 谷崎 勝朗| |
| 抄録 | Background: Assessment of low attenuation areas and lung densitometry on high resolution computed tomography (HRCT) have been reported in studies of patients with chronic obstructive pulmonary disease. Objective : The purpose of this study was to examine if HRCT could separate asthmatic patients from normal control subjects and patients with emphysema. Methods : Subjects were divided into three groups : 24 patients with bronchial asthma, 23 patients with pulmonary emphysema and 15 normal controls. HRCT scans of the lung were performed at three different levels at both end inspiration and expiration in all patients and control subjects. Results : The mean CT number of three slices was significantly lower in asthmatic subjects compared with normal individuals at both end inspiration (p < 0.05) and expiration (p < 0.01). The relative area of the lung with an attenuation value lower than -950 HU (% LAA) for three slices was significantly higher in asthmatic subjects than in normal individuals at end inspiration (p < 0.05), but there was no significant difference at end expiration. The mean CT number and % LAA obtained from studies that were performed at three cm above the top of the diaphragm provided the best separation among three anatomic levels. In comparison between asthmatic and emphysema patients, both parameters were significantly different in asthmatic subjects than in those with emphysema at both end inspiration and expiration on each scan and in the total scans (p < 0.001). Conclusions : HRCT is a useful method to separate asthmatic subjects from patients with emphysema and normal subjects. |
| キーワード | HRCT asthma emphysema |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 19 |
| 終了ページ | 28 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308115 |
| JaLCDOI | 10.18926/14904 |
|---|---|
| タイトル（別表記） | 高齢者気管支喘息における気道過敏性と温泉療法 |
| フルテキストURL | 071_010_018.pdf |
| 著者 | 谷崎 勝朗| 光延 文裕| 御舩 尚志| 保﨑 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 高田 真吾| 越智 浩二| |
| 抄録 | Clinical effects of spa therapy were examined in 150 patients with asthma in relation tobronchial hyperresponsiveness and patient age. 1. The efficacy rate of spa therapy was larger as the patient age was higher: the rate was 73.3% in patients under age 49, 81.8% in those between the ages of 50 and 59, 86.4% in those between the ages of 60 and 69, and 90.6% in those over age 70. The mean of efficacy rates was 83.3% in all subjects. 2. The bronchial hyperresponsiveness (BH) was lower as patient age was higher: the BH in patients between the ages of 60 and 69 and in those over age 70 was significantly lower compared to the BH in those under age 49 (p < O.OOl). 3. Clinical effects of spa therapy tended to be lower in patients with increased bronchial hyperresponsiveness. The bronchial hyperresponsiveness showed a tendency to decrease after spa therapy in whom the therapy was effective, however, the BH did not change in patients with slight or no efficacy during spa therapy. |
| キーワード | spa therapy asthma bronchial hyperresponsiveness patient age |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2001-02-01 |
| 巻 | 71巻 |
| 開始ページ | 10 |
| 終了ページ | 18 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308660 |
| JaLCDOI | 10.18926/14900 |
|---|---|
| タイトル（別表記） | Fluticasone 投与にもかかわらず症状が軽快ぜすn-3系不飽和脂肪酸強化食による食事療法及びモンテルカストが著効した気管支喘息の１例 |
| フルテキストURL | 076_053_059.pdf |
| 著者 | 高田 真吾| 芦田 耕三| 保崎 泰弘| 濱田 全紀| 岩垣 尚史| 菊池 宏| 光延 文裕| |
| 抄録 | A 25-year-old woman had the chief complaint of recurrent episodes of dyspnea and wheeze. Asthma had been diagnosed at infant years and sometimes experienced asthma attacks. She graduated senior high school and entered technical school in Tokyo. She received fluticasone (400μg daily) but exacerbation continued after she became an office clerk. She returned Kurashiki in October 2001 but had wheeze and asthma exacerbations. She was admitted to our hospital for evaluation and treatment of bronchial asthma on August 2, 2002. After admission, her symptoms subsided within some days. She was treated with montelukast and perilla seed oil-rich supplementation . The number of eosinophils decreased, decrease was observed in leukotriene (LT) B4 generation and in LTC4 generation, and pulmonary function improved following montelukast and perilla seed oil-rich supplementation for 4 weeks. The patient had no exacerbation under treatment and was discharged from the hospital on September 2, 2002. For some patients with persistent asthma, inhaled corticosteroids may fail to achieve adequate control possibly because corticosteroids do not completely inhibit the synthesis and release of cysteinyl leukotrienes (cysLTs) in the lung. Montelukast blocks the interaction of cysLTs with their receptor and resulting downstream events and perilla seed oil-rich diet suppresses LT generation. Combination therapy with montelukast and perilla seed oil-rich diet is more effective than montelukast or perilla seed oil-rich diet alone because of additive effects of montelukast with perilla seed oil-rich diet. We suggest that montelukast and perilla seed oil-rich supplementation are effective options when bronchial asthma patients receive inhaled corticosteroid but exacerbation continues. |
| キーワード | モンテルカスト (montelukast) 気管支喘息 (bronchial asthma) ロイコトリエンC4 (leukotriene C4) エゴマ油食 (perilla seed oil-rich supplementation) フルチカゾン (fluticasone) |
| 出版物タイトル | 岡大三朝医療センター研究報告 |
| 発行日 | 2008-03-01 |
| 巻 | 76巻 |
| 開始ページ | 53 |
| 終了ページ | 59 |
| ISSN | 1348-1258 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308179 |
| JaLCDOI | 10.18926/14895 |
|---|---|
| タイトル（別表記） | 慢性閉塞性肺疾患患者における温泉療法の６分間歩行に対する効果 |
| フルテキストURL | 076_024_030.pdf |
| 著者 | 高田 真吾| 芦田 耕三| 保崎 泰弘| 濱田 全紀| 岩垣 尚史| 菊池 宏| 光延 文裕| |
| 抄録 | Our previous studies have shown that subjective symptoms and ventilatory function are improved by spa therapy in patients with chronic obstructive pulmonary disease (COPD). In the present study, we investigated the effects of spa therapy on six-minute walk distance in patients with COPD . Subjects were 10 patients with chronic obstructive pulmonary disease (9 males and 1 female) admitted to our hospital to undergo pulmonary rehabilitation. All patients had complex spa therapy (swimming training in a hot spring pool, inhalation of iodine salt solution, and fango therapy) for 4 weeks. Ventilatory function, six-minute walk distance, oxygen saturation and Borg scale were measured. Vital capacity, forced expiratory volume in one second, sixminute walk distance and oxygen saturation increased, but not significantly. Significant decreases were observed for Borg scale. We found that spa therapy improved ventilatory dysfunction and six-minute walk distance in patients with COPD. The results demonstrated that spa therapy may lead to better disease control and exercise tolerance in patients with COPD. |
| キーワード | Chronic obstructive pulmonary disease (慢性閉塞性肺疾患) Spa therapy (温泉療法) Six-minute walk test (６分間歩行試験) Borg scale (ボルグスケール) Ventilatory function (呼吸機能) |
| 出版物タイトル | 岡大三朝医療センター研究報告 |
| 発行日 | 2008-03-01 |
| 巻 | 76巻 |
| 開始ページ | 24 |
| 終了ページ | 30 |
| ISSN | 1348-1258 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308319 |
| JaLCDOI | 10.18926/14839 |
|---|---|
| タイトル（別表記） | 脂質代謝に関連した気管支喘息患者における白血球ロイコトリエン産生能に対するα-リノレン酸食の効果 |
| フルテキストURL | 72_045_054.pdf |
| 著者 | 岡本 誠| 光延 文裕| 芦田 耕三| 保崎 泰弘| 柘野 浩史| 西田 典教| 横井 正| 高田 真吾| 谷崎 勝朗| 谷本 光音| |
| 抄録 | Dietary sources of a -linolenic acid, such as perilla seed oil, may have the capacity to inhibit the generation of leukotrienes (LTs) by leucocytes in patients with
asthma, as has been reported with the consumption of other long - chain n- 3 fatty a-cids.
The factors affecting the suppression of leukotriene (LT) C4 generation by leucocytes were examined by comparing the clinical features of patients with asthma who had been given dietary perilla seed oil (n - 3 fatty acids). Group A consisted of patients in whom the leucocyte generation of dietary perilla seed oil LTC4 was suppressed by this procedure. Group B consisted of those in whom LTC4 generation was not suppressed. LTC4 generation by leucocytes significantly decreased in group A for two (P<0.05) and four weeks (P |
| キーワード | alpha -linolenic acid leukotrieneC4 bronchial asthma lipometabolism |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2002-02-01 |
| 巻 | 72巻 |
| 開始ページ | 45 |
| 終了ページ | 54 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308212 |
| JaLCDOI | 10.18926/14838 |
|---|---|
| フルテキストURL | 72_038_044.pdf |
| 著者 | 芦田 耕三| 光延 文裕| 保崎 泰弘| 柘野 浩史| 岡本 誠| 西田 典教| 高田 真吾| 横井 正| 谷崎 勝朗| |
| 抄録 | Changes in the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes after spa therapy were examined in 30 patients with asthma.
1. The efficacy of spa therapy was marked in 8 (26.7%), and moderate in 16 (53.3%) of 30 patients with asthma, and slight or no efficacy of the therapy was observed in the residual 6 patients (20.0%).
2. Bronchial reactivity to methacholine was the highest in
patients with slight or no efficacy of spa therapy, however. there were no significant differences among the three groups classified by clinical efficacy.
3. The generation of LTC4 was significantly higher in patients with slight or no efficacy compared with the
generation in those with marked (p |
| キーワード | asthma spa therapy bronchial hyperresponsiveness LTB4 LTC4 |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2002-02-01 |
| 巻 | 72巻 |
| 開始ページ | 38 |
| 終了ページ | 44 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308539 |
| JaLCDOI | 10.18926/14837 |
|---|---|
| フルテキストURL | 72_031_037.pdf |
| 著者 | 保崎 泰弘| 光延 文裕| 芦田 耕三| 柘野 浩史| 岡本 誠| 西田 典教| 高田 真吾| 横井 正| 谷崎 勝朗| 越智 浩二| 辻 孝夫| |
| 抄録 | The purpose of this study is to establish a new, non - invasive diagnostic technique for peripheral circulation in patients with diabetes mellitus in the early stage of arteriosclerosis obliterans (ASO) as one of the complications of diabetes mellitus. We observed peripheral circulation quantitatively by thermography and Laser- Doppler blood flowmetry. The body surface peripheral circulation in 27 patients with diabetes mellitus, including 14 males and 13 females with a mean age of 67.4 years (range from 51-82 years), and with a mean hemoglobin A1C (HbA1C) 019.5% (range from 6.8%-13.0%), and who were suffering coldness, numbness or pain in their feet, was examined using thermography and Laser- Doppler blood flowmetry. Thermographic results
were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio= [Total counts of thermography (Pixels) over temperature (T) after cold -loading] + [Initial counts over T after hot-loading] Xl00 (%). Results of recovery ratios for 27 cases were 0% - 93.5%, and the average was 34.0%. At the same time, the blood flow after cold -loading was 0.91 - 5. 36ml/min/lOOg tissue and the average was 2.04ml/min/l00g tissue. We found that the recovery ratio
and the blood flow were correlated (r=O. 634, p |
| キーワード | diabetes mellitus (糖尿病) peripheral circulation (末梢循環) thermography (サーモグラフィー) Laser-Doppler blood flowmetry (レーザードプラー血流計) blood flow (血流量) |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2002-02-01 |
| 巻 | 72巻 |
| 開始ページ | 31 |
| 終了ページ | 37 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308058 |
| JaLCDOI | 10.18926/14836 |
|---|---|
| タイトル（別表記） | 高齢者気管支喘息の臨床病態におけるロイコトリエンB4,C4の役割. 気道過敏性とFEV1.0%との関連 |
| フルテキストURL | 72_023_030.pdf |
| 著者 | 光延 文裕| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 西田 典教| 高田 真吾| 横井 正| 谷崎 勝朗| |
| 抄録 | The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 67 patients with asthma. 1. The generation of leukotriene B4 (LTB4) by leucocytes was significantly more increased in patients with asthma than in those with pulmonary emphysema (PE) and healthy subjects. The generation of leukotriene C4 (LTC4) was also signficantly more increased in patients with asthma compared to the generation in those with PE and healthy subjects. The generation of both LTB4 and LTC4 was significantly more increased in patients with PE than in healthy subjects. 2. The generation of both LTB4 and LTC4 was larger in patients with asthma over age 70 than in those of other age groups, however, the difference was not significant. 3. The generation of LTC4 was significantly higher in attack stage than in non-attack stage in all age groups of patients with asthma, however, the generation of LTB4 was not significantly different between the two stages. 4. Bronchial hyperresponsiveness to methacholine in patients with asthma tended to decrease with aging, and the bronchial hyperresponsiveness was to a certain extent correlated with the generation of LTB4, but not LTC4. 5. The generation of LTC4 was correlated with value of FEV1.0%. These results may suggest that both LTB4 and LTC4 participate in the pathophysiology of asthma in the elderly. |
| キーワード | asthma LTB4 LTC4 FEV1.0% bronchial hyperresponsiveness |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2002-02-01 |
| 巻 | 72巻 |
| 開始ページ | 23 |
| 終了ページ | 30 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308466 |
| JaLCDOI | 10.18926/14835 |
|---|---|
| タイトル（別表記） | 気管支喘息における気管支肺胞洗浄液中の細胞成分に対する加齢および副腎皮質ホルモンの影響 |
| フルテキストURL | 72_016_022.pdf |
| 著者 | 光延 文裕| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 西田 典教| 高田 真吾| 横井 正| 谷崎 勝朗| |
| 抄録 | Effects of aging and glucocorticoid therapy on bronchoalveolar lavage (BAL) cells, particularly lymphocytes, neutrophils and eosinophils, were examined in 81 patients with asthma. 1. The proportion of BAL lymphocytes tended to increase with aging in asthmatics under age 69 years, and the proportion was significantly higher in patients with asthma between the ages of 60 and 69 than in those under age 39 and between the ages of 40 and 49. 2. The proportions of BAL neutrophils and eosinophils were not related to aging. 3. The proportion of BAL lymphocytes was higher in patients without glucocorticoid therapy than in those with steroid-dependent intractable asthma (SOIA) in those under age 69 years. In patients between the ages of 50 and 59, the proportion of BAL lymphocytes was significantly higher in patients without glucocorticoids than in those with SOIA. 4. The proportion of BAL neutrophils was higher in patients without glucocorticoid therapy than in those with SOIA, and the difference was significant in patients between the ages of 60 and 69. 5. The proportion of BAL eosinophils was not related to glucocorticoid therapy. These results suggest that the proportion of BAL lymphocytes and neutrophils is affected by aging and glucocorticoid therapy, but not BAL eosinophils. |
| キーワード | aging asthma glucocorticoid therapy BAL cells |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2002-02-01 |
| 巻 | 72巻 |
| 開始ページ | 16 |
| 終了ページ | 22 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308605 |
| JaLCDOI | 10.18926/14834 |
|---|---|
| タイトル（別表記） | HRCT上の肺のLow Attenuation Areaおよび肺機能により評価された高齢者善喘息の特徴 |
| フルテキストURL | 72_009_015.pdf |
| 著者 | 光延 文裕| 保崎 泰弘| 芦田 耕三| 柘野 浩史| 岡本 誠| 西田 典教| 高田 真吾| 横井 正| 中井 睦郎| 谷崎 勝朗| |
| 抄録 | The clinical significance of low attenuation area <-950 HU of the lungs on high - resolution computed tomography (HRCT) was evaluated in 80 patients with asthma in relation to patient age, CT number, pulmonary function including % residusal volume (% RV) and % DLco, and generation of leukotrienes B4 and C4 by leucocytes.
1. The % LAA (<- 950 HU) of the lungs showed a tendency to increase significantly with aging; the % LAA was significantly larger in elderly patients over the age of 60 years than in those under the age of 49 years. The CT number was also significantlyincreased with aging.
2. The values of % FVC, % FEV1.0, and FEV1.0% were
significantly decreased in elderly patients over age 70 compared with the values in those under age 49.
3. The value of % residual volume (% RV) tended to increase significantly with aging; the value in patients over the age of 70 years was significantly larger in those between the ages of 50 and 59 (p |
| キーワード | low attenuation area of the lung CT number residual volume DLco aging |
| 出版物タイトル | 岡大三朝分院研究報告 |
| 発行日 | 2002-02-01 |
| 巻 | 72巻 |
| 開始ページ | 9 |
| 終了ページ | 15 |
| ISSN | 0918-7839 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002308131 |