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JaLCDOI 10.18926/ATM/61436
フルテキストURL 75_1_63.pdf
著者 Tada, Katsuhiko| Miyagi, Yasunari| Nakamura, Kazue| Yorozu, Moe| Fukushima, Emi| Kumazawa, Kazumasa| Nakamura, Makoto| Kageyama, Misao|
抄録 We used a differential equation to identify the biological relationship between the maternal prepregnancy body mass index (BMI) and lactation on postpartum day 4 in Japanese women with neonatal separation. This retro-spective observational study included 252 mothers (135 primiparas, 117 multiparas) whose singleton neonates were admitted to a neonatal ICU. We formulated hypotheses based on breast anatomy to analyze the relation-ship between the expressed milk obtained on postpartum day 4 and the maternal prepregnancy BMI with the following differential equation: y’(x) = k y(x)/x, where k is the constant, x is the prepregnancy BMI, and y is the expressed milk volume. The formula was then obtained as y(x) = axk, where a is the constant. The Akaike information criterion (AIC) was used to estimate the regression equation with the maximum likelihood for primiparas and multiparas. The best criteria for BMI determined by the AIC were 20.89 kg/m2 in primiparas and 20.19 kg/m2 in multiparas. These were the optimal BMI values for lactation, coinciding with the median prepregnancy BMI in the study population (20.78 kg/m2 in primiparas and 20.06 kg/m2 in multiparas). The formula based on biomathematics might help establish the biological relationship between prepregnancy BMI and breastmilk volume.
キーワード biomathematics body mass index expressed milk lactation
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-02
75巻
1号
出版者 Okayama University Medical School
開始ページ 63
終了ページ 69
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33649615
JaLCDOI 10.18926/AMO/61435
フルテキストURL 75_1_55.pdf
著者 Kubo, Yujiro| Watanabe, Mototsugu| Choshi, Haruki| Matsubara, Kei| Shiotani, Toshio| Kataoka, Kazuhiko|
抄録 Small pulmonary lesions are often difficult to localize during thoracoscopic surgery. We describe a new com-puted tomography (CT)-guided pleural dye-marking method for small peripheral pulmonary lesions that does not involve a visceral pleural puncture. We used this technique for 23 lesions (22 patients) who underwent tho-racoscopic partial lung resection (Nov. 2016-Jan. 2018). With the patient in the lateral decubitus position, pre-operative CT-guided marking on the skin over the lesion was performed. During the surgery, we marked the visceral pleura with a skin marker directly or with an infant-size nutrition catheter with crystal violet at the tip through a venous indwelling needle inserted perpendicular to the skin marking. We localized and resected the lesions in all cases, without complications. The median nodule size measured histopathologically was 8 (4-20) mm overall, and 7 (0-20) mm of the solid part; the median distance from the visceral pleura to the nodule was 9 (1-33) mm. The median operation time was 67 (37-180) min. The median postoperative hospital stay was 3 (3-11) days. Our CT-guided pleural dye-marking method is useful and safe for the localization of small periph-eral pulmonary lesions in thoracoscopic partial lung resections.
キーワード Small pulmonary lesion ground glass nodule marking localization thoracocentesis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-02
75巻
1号
出版者 Okayama University Medical School
開始ページ 55
終了ページ 61
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33649614
JaLCDOI 10.18926/AMO/61433
フルテキストURL 75_1_45.pdf
著者 Otsuka, Hiroaki| Miyoshi, Toru| Ejiri, Kentaro| Kohno, Kunihisa| Nakahama, Makoto| Doi, Masayuki| Munemasa, Mitsuru| Murakami, Masaaki| Nakamura, Kazufumi| Ito, Hiroshi|
抄録 Remote ischemic preconditioning (RIPC) is a promising strategy for protecting against ischemic reperfusion injury. This study is a secondary analysis of a randomized study that aimed to evaluate the effect of RIPC on the early increase in serum creatinine (SCr) following percutaneous coronary intervention (PCI), which is associ-ated with contrast-induced acute kidney injury. Patients with stable angina undergoing elective PCI were assigned to control, RIPC, and continuous infusion of nicorandil (nicorandil) groups. The endpoint of this study was the incidence of the early increase in SCr, a predictor of contrast-induced acute kidney injury, which was defined as either a > 20% or absolute increase by 0.3 mg/dl of SCr levels after 24 h of PCI. This study included 220 patients for whom a dataset of SCr values was available. The incidence of the early increase in SCr was significantly lower in the RIPC than in the control (1.3% vs 10.8%, p = 0.03) group, but was not significantly different between the nicorandil and control groups. In multivariate analysis, RIPC remained a significant fac-tor associated with a reduction in the incidence of early increase in SCr. RIPC reduces the incidence of early increase in SCr in patients with stable angina following elective PCI.
キーワード remote ischemic preconditioning stable angina serum creatinine acute kidney injury
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-02
75巻
1号
出版者 Okayama University Medical School
開始ページ 45
終了ページ 53
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33649613
JaLCDOI 10.18926/AMO/61432
フルテキストURL 75_1_39.pdf
著者 Akezaki, Yoshiteru| Nakata, Eiji| Kikuuchi, Masato| Tominaga, Ritsuko| Kurokawa, Hideaki| Hamada, Makiko| Aogi, Kenjiro| Ohsumi, Shozo| Sugihara, Shinsuke|
抄録 In this study, we examined whether axillary web syndrome (AWS) in patients with breast cancer following axil-lary lymph node dissection affects range of motion (ROM), upper extremity function, and quality of life (QOL). The risk factors for AWS were also evaluated in a total of 238 consecutive breast cancer patients follow-ing axillary lymph node dissection. At 1, 2, and 3 months after surgery, there were no significant differences between the AWS group and the non-AWS group in upper-limb function or QOL. At 2 months after surgery, shoulder flexion and abduction ROM were significantly higher in the AWS group than in the non-AWS group (p < 0.05). Self-training time at home was not significantly different between the groups at 1, 2, or 3 months. Only age was a significant predictor of AWS at 1 month after surgery (p < 0.05). The AWS group in the present study did not have worse results for shoulder joint ROM, upper-limb function, and QOL than the non-AWS group. Younger age should be useful for predicting the development of AWS in the early postoperative period.
キーワード breast cancer axillary web syndrome age upper limb function quality of life
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-02
75巻
1号
出版者 Okayama University Medical School
開始ページ 39
終了ページ 44
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33649612
JaLCDOI 10.18926/AMO/61431
フルテキストURL 75_1_31.pdf
著者 Miyamaru, Satoru| Murakami, Daizo| Nishimoto, Kohei| Saito, Haruki| Miyamoto, Yusuke| Hirota, Kaoruko| Ise, Momoko| Orita, Yorihisa|
抄録 Although the lung is the most common site of distant metastases from head and neck squamous cell carcinoma (HNSCC), the number of reports about the effects of pulmonary metastasectomy for the treatment of lung metastasis from HNSCC is limited. Metachronous pulmonary metastases were detected in 45 HNSCC patients at Kumamoto University Hospital from 1998 to 2018. Twenty-two patients underwent an operative resection (Ope group) and 23 underwent chemotherapy (Chemo group). The 3-year overall survival (OS) rate and median OS were evaluated. The effects of adjuvant chemotherapy after pulmonary metastasectomy and of new drugs (cetuximab and nivolumab), in the chemo group were also assessed. The 3-year OS rates and median OS were: Ope, 66.1% and 31.5 months; Chemo, 39.7% and 18 months, respectively. In the Ope group, addi-tional recurrences were significantly fewer in the patients who underwent adjuvant chemotherapy post-surgery versus the patients who underwent surgery alone (p = 0.013). In the Chemo group, the 3-year OS rate of the patients who received new drugs was significantly better than that of the patients who did not (p = 0.021). Adjuvant chemotherapy after pulmonary metastasectomy may be a preferable treatment option for preventing recurrences. Cetuximab and nivolumab have a potential to improve OS.
キーワード pulmonary metastasis head and neck squamous cell carcinoma pulmonary metastasectomy adjuvant chemotherapy
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-02
75巻
1号
出版者 Okayama University Medical School
開始ページ 31
終了ページ 37
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33649611
JaLCDOI 10.18926/AMO/61430
フルテキストURL 75_1_25.pdf
著者 Tetsunaga, Tomonori| Tetsunaga, Tomoko| Yamada, Kazuki| Sanki, Tomoaki| Kawamura, Yoshi| Ozaki, Toshifumi|
抄録 In bipolar hemiarthroplasty (BHA), it is important to preserve soft tissue to reduce the risk of postoperative dislocation. A variety of surgical approaches for BHA are available, but extra care is needed with muscle- and tendon-preserving approaches in geriatric patients. We investigated the usefulness of BHA using a conjoined tendon-preserving posterior (CPP) approach, in which only the external obturator muscle is dissected, in geri-atric patients. We retrospectively analyzed the cases of 40 femoral neck fracture patients (10 men, 30 women) aged ≥ 80 years who underwent BHA using the CPP approach. The patients’ average age was 85.8 years (80-94 years). We examined the operation time, bleeding, preservation of short external rotator muscles, complica-tions, and stem alignment and subsidence from postoperative radiographs. Although gemellus inferior muscle injury was detected in 4 patients (10%), the hip joint stability was very excellent in all cases. There was no intraoperative fracture or postoperative dislocation. On postoperative radiographs, all femoral stems were in a neutral position. There was no stem subsidence in all 40 patients. BHA using the CPP approach appeared to be useful even in geriatric patients.
キーワード bipolar hip arthroplasty geriatric patient conjoined tendon-preserving posterior approach
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-02
75巻
1号
出版者 Okayama University Medical School
開始ページ 25
終了ページ 30
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33649610
JaLCDOI 10.18926/AMO/61429
フルテキストURL 75_1_15.pdf
著者 Katsui, Kuniaki| Ogata, Takeshi| Tada, Akihiro| Sugiyama, Soichi| Yoshio, Kotaro| Kuroda, Masahiro| Kiura, Katsuyuki| Maeda, Yoshinobu| Toyooka, Shinichi| Hiraki, Takao| Kanazawa, Susumu|
抄録 The aim of this study was to investigate whether volumetric positron emission tomography (PET) parameters are prognostic predictors in stage III non-small cell lung cancer patients receiving definitive concurrent chemo-radiotherapy (CCRT) with cisplatin/docetaxel. Cases involving definitive CCRT were reviewed retrospectively, and the maximum standardized uptake value, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated. The relationships between these PET parameters and prognosis were analyzed. MTV and TLG were significant predictors of distant metastasis-free survival (DMFS) (p = 0.0003 and 0.0005, respectively) and progression-free survival (PFS) (p = 0.001 and 0.0007, respectively). The three-year DMFS rates in patients with low and high MTV were 13.3% and 64.6%, respectively, and the corresponding values in those with low and high TLG were 13.3% and 65.2%, respectively. The three-year PFS rates in patients with low and high MTV were 13.3% and 57.8%, respectively, and the corresponding values in patients with low and high TLG were 13.3% and 57.8%, respectively. However, MTV and TLG were not predictors of local control or overall sur-vival. We demonstrated that volumetric PET parameters were predictors of patients receiving definitive CCRT. Our findings contradict the findings of previous reports and warrant further research to validate them.
キーワード volumetric positron emission tomography parameters distant metastasis-free survival chemoradiotherapy cisplatin/docetaxel non-small cell lung cancer
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-02
75巻
1号
出版者 Okayama University Medical School
開始ページ 15
終了ページ 23
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33649609
JaLCDOI 10.18926/AMO/61428
フルテキストURL 75_1_9.pdf
著者 Gobara, Hideo| Yamamoto, Akira| Komakic, Toshiyuki| Kitayama, Toshiaki| Sakurai, Jun| Iguchi, Toshihiro| Matsui, Yusuke| Uka, Mayu| Tomita, Koji| Hiraki, Takao| Kanazawa, Susumu|
抄録 To assess the feasibility of needle tract ablation in liver tissue in ex vivo and in vivo animal models using a cryo-probe and electrosurgical device. The experimental device is made by inserting a cryoprobe through an intro-ducer sheath for insulation, with 2-cm of probe tip projecting out. A beagle liver was punctured by the device, and electric current was applied at 30-W with the electrosurgical knife touching the non-insulated device base. The discolored area of cut surface along the device was evaluated in 5 application-time groups (5 , 10 , 15 , 20, or 25 seconds). An ex vivo experiment was performed to determine an ablation algorithm with an appropriate application time by comparison with radiofrequency ablation (RFA) results. Thereafter, an in vivo experiment was performed to verify the algorithm’s feasibility. In the ex vivo model, the cut surface demonstrated different amounts of discolored area according to the application time. The total discolored area in the 20-seconds group was similar to that by RFA. In the in vivo model, the liver did not bleed, the total discolored area was similar to that ex vivo, and coagulation necrosis was confirmed by photomicrograph. Needle tract ablation can be per-formed using the experimental device and electrosurgical device.
キーワード needle tract ablation cryoablation electrosurgical device animal liver
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-02
75巻
1号
出版者 Okayama University Medical School
開始ページ 9
終了ページ 14
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33649608
JaLCDOI 10.18926/AMO/61424
フルテキストURL 75_1_1.pdf
著者 Hamahara, Jun| Honda, Hiroyuki| Yamamoto, Koichiro| Tokumasu, Kazuki| Hanayama, Yoshihisa| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio|
抄録 To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males.
キーワード androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2021-02
75巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 8
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33649607
フルテキストURL fulltext.pdf
著者 Yano, Shuya| Tazawa, Hiroshi| Kishimoto, Hiroyuki| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| Hoffman, Robert M.|
キーワード cancer cell cycle fluorescent proteins FUCCI imaging adenovirus oncolytic virotherapy cancer stem cell mouse model orthotopic
発行日 2021-01-17
出版物タイトル International Journal of Molecular Sciences
22巻
2号
出版者 MDPI
開始ページ 879
ISSN 1422-0067
NCID AA12038549
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 33477279
DOI 10.3390/ijms22020879
Web of Science KeyUT 000611296000001
関連URL isVersionOf https://doi.org/10.3390/ijms22020879
フルテキストURL fulltext.pdf
著者 Hassan, Ghmkin| Afify, Said M.| Kitano, Shiro| Seno, Akimasa| Ishii, Hiroko| Shang, Yucheng| Matsusaki, Michiya| Seno, Masaharu|
キーワード cancer stem cells biomaterial scaffolds tumor microenvironment drug screening
発行日 2020-12-28
出版物タイトル Processes
9巻
1号
出版者 MDPI
開始ページ 45
ISSN 2227-9717
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 by the authors.
論文のバージョン publisher
DOI 10.3390/pr9010045
Web of Science KeyUT 000610776800001
関連URL isVersionOf https://doi.org/10.3390/pr9010045
フルテキストURL fulltext.pdf
著者 Kojima, Keiichi| Yoshizawa, Susumu| Hasegawa, Masumi| Nakama, Masaki| Kurihara, Marie| Kikukawa, Takashi| Sudo, Yuki|
発行日 2020-11-30
出版物タイトル Scientific Reports
10巻
1号
出版者 Nature Research
開始ページ 20857
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2020
論文のバージョン publisher
PubMed ID 33257762
DOI 10.1038/s41598-020-77936-9
Web of Science KeyUT 000609202800018
関連URL isVersionOf https://doi.org/10.1038/s41598-020-77936-9
フルテキストURL fulltext.pdf
著者 Takagi, Kosei | Kimenai, Hendrikus J. A. N.| Terkivatan, Turkan| Tran, Khe T. C.| Ijzermans, Jan N. M.| Minnee, Robert C.|
キーワード Kidney transplantation Living donors Nephrectomy Laparoscopy Hand-assisted laparoscopy Learning curve Education Teaching
発行日 2020-06-15
出版物タイトル Surgical Endoscopy
出版者 Springer
ISSN 0930-2794
NCID AA10750363
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The authors.
論文のバージョン publisher
PubMed ID 32556762
DOI 10.1007/s00464-020-07727-w
Web of Science KeyUT 000540992500014
関連URL isVersionOf https://doi.org/10.1007/s00464-020-07727-w
フルテキストURL fulltext.pdf
著者 Pham, Hai Thanh| Ono, Mitsuaki| Hara, Emilio Satoshi| Nguyen, Ha Thi Thu| Dang, Anh Tuan| Do, Hang Thuy| Komori, Taishi| Tosa, Ikue| Hazehara-Kunitomo, Yuri| Yoshioka, Yuya| Oida, Yasutaka| Akiyama, Kentaro| Kuboki, Takuo|
キーワード amino acid mesenchymal stromal cells stemness tryptophan kynurenine osteogenesis adipogenesis screening injury/fracture healing anabolics
発行日 2021-01-04
出版物タイトル Materials
14巻
1号
出版者 MDPI
開始ページ 208
ISSN 1996-1944
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 by the authors.
論文のバージョン publisher
PubMed ID 33406724
DOI 10.3390/ma14010208
Web of Science KeyUT 000606251400001
関連URL isVersionOf https://doi.org/10.3390/ma14010208
フルテキストURL fulltext.pdf
著者 Li, Huan| Wang, Yanan| Nishiyama, Saki| Yang, Xiaofan| Taguchi, Tomoya| Miura, Akari| Suzuki, Ai| Zhi, Lei| Goto, Hidenori| Eguchi, Ritsuko| Kambe, Takashi| Liao, Yen-Fa| Ishii, Hirofumi| Kubozono, Yoshihiro|
発行日 2020-07-16
出版物タイトル RSC Advances
10巻
45号
出版者 Royal Society of Chemistry
開始ページ 26686
終了ページ 26692
ISSN 2046-2069
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Royal Society of Chemistry
論文のバージョン publisher
DOI 10.1039/D0RA04541A
Web of Science KeyUT 000555612200011
関連URL isVersionOf https://doi.org/10.1039/D0RA04541A
フルテキストURL fulltext.pdf
著者 Sakai, Shunsuke| Hatabu, Toshimitsu| Yamamoto, Yuki| Kimura, Koji|
キーワード chemokine cow endometrial cells endometritis heat stress
発行日 2020-11-23
出版物タイトル Physiological Reports
8巻
22号
出版者 Wiley
開始ページ e14640
ISSN 2051-817X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 The Authors.
論文のバージョン publisher
PubMed ID 33230953
DOI 10.14814/phy2.14640
Web of Science KeyUT 000596091500001
関連URL isVersionOf https://doi.org/10.14814/phy2.14640
フルテキストURL fulltext.pdf
著者 Ito, S.| Ichimura, K.| Takaku, Y.| Abe, K.| Harada, M.| Ikeda, M.| Ito, H.| Kishimoto, Y.| Nakajima, Y.| Okada, T.| Sekiya, H.|
発行日 2020-09-20
出版物タイトル Progress of Theoretical and Experimental Physics
2020巻
9号
出版者 Oxford University Press
開始ページ 093H02
ISSN 2050-3911
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2020.
論文のバージョン publisher
DOI 10.1093/ptep/ptaa105
Web of Science KeyUT 000593154500018
関連URL isVersionOf https://doi.org/10.1093/ptep/ptaa105
フルテキストURL fulltext.pdf
著者 Nakano, Ryohei| Kawai, Takashi| Fukamatsu, Yosuke| Akita, Kagari| Watanabe, Sakine| Asano, Takahiro| Takata, Daisuke| Sato, Mamoru| Fukuda, Fumio| Ushijima, Koichiro|
キーワード fruit softening ethylene Prunus persica melting flesh locus endoPG postharvest
発行日 2020-11-26
出版物タイトル Frontiers in Plant Science
11巻
出版者 Frontiers Media
開始ページ 554158
ISSN 1664-462X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 Nakano, Kawai, Fukamatsu, Akita, Watanabe, Asano, Takata, Sato, Fukuda and Ushijima.
論文のバージョン publisher
PubMed ID 33324428
DOI 10.3389/fpls.2020.554158
Web of Science KeyUT 000596841900001
関連URL isVersionOf https://doi.org/10.3389/fpls.2020.554158
フルテキストURL fulltext.pdf
著者 Afify, Said M.| Calle, Anna Sanchez| Hassan, Ghmkin| Kumon, Kazuki| Nawara, Hend M.| Zahra, Maram H.| Mansour, Hager M.| Khayrani, Apriliana Cahya| Alam, Md Jahangir| Du, Juan| Seno, Akimasa| Iwasaki, Yoshiaki| Seno, Masaharu|
キーワード Cancer models Cancer stem cells
発行日 2020-03-17
出版物タイトル British Journal of Cancer
122巻
9号
出版者 Springer Nature
開始ページ 1378
終了ページ 1390
ISSN 0007-0920
NCID AA00574355
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Authors
論文のバージョン publisher
PubMed ID 32203212
DOI 10.1038/s41416-020-0792-z
Web of Science KeyUT 000519841900001
関連URL isVersionOf https://doi.org/10.1038/s41416-020-0792-z
JaLCDOI 10.18926/AMO/61217
フルテキストURL 74_6_557.pdf
著者 Ishiguro, Mikako| Takenaka, Ryuta| Ogura, Kenichiro| Hiratsuka, Akira| Takeda, Hiromasa| Kawai, Daisuke| Tsugeno, Hirofumi| Fujiki, Shigeatsu| Okada, Hiroyuki|
抄録 A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively.
キーワード 5-fluorouracil dihydropyrimidine dehydrogenase deficiency DPYD variant gastric cancer
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2020-12
74巻
6号
出版者 Okayama University Medical School
開始ページ 557
終了ページ 562
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 33361878
Web of Science KeyUT 000601203600014
NAID 120006948944