検索結果 3341 件
| JaLCDOI | 10.18926/CTED/55818 |
|---|---|
| タイトル（別表記） | A Study on Parental Anxiety Over Child Rearing and Child Care Support for Parents with Children before and after Entering Elementary Schools |
| フルテキストURL | cted_008_193_206.pdf |
| 著者 | 岡﨑 由美子| 安藤 美華代| |
| 抄録 | 本研究では，就学前後の子をもつ養育者が，子育てで感じている喜びや不安，必要としている支援について検討し，子育て支援のあり方について考察した。子ども園に通う3から5歳児の保護者と小学1，2年生児の保護者に子育てに関する自記式調査を行い，回答を得られた166名の記述内容について検討した。質的分析から，子ども園児・小学校児童の保護者とも，子どもの成長や姿，一緒に行動することに喜びを感じていた。一方，子ども園や学校での適応や保護者自身の子どもへの対応に不安を感じていた。このような状況から養育者への支援として，就学前教育と小学校教育の連携の強化，保護者同士の交流の場や機会の提供，相談体制の整備，子育てに関する講演会や心理教育の提供，子育て支援に関する満足度の定期的見立てが重要であると考えられた。以上より，子育て支援には，心理的支援を含めた多面的な支援が重要であることが示唆された。 |
| キーワード | 養育者 (parent) 子育て不安 (child rearing anxiety) 子育て支援 (child care support) 就学前後 (before and after entering elementary school) 心理的支援 (psychological support) |
| 出版物タイトル | 岡山大学教師教育開発センター紀要 |
| 発行日 | 2018-03-20 |
| 巻 | 8巻 |
| 開始ページ | 193 |
| 終了ページ | 206 |
| ISSN | 2186-1323 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2018 岡山大学教師教育開発センター |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/CTED/55806 |
|---|---|
| タイトル（別表記） | A Study on Psychological Distress and the Coping Strategies of Coaches in School-based Extracurricular Sports Activities |
| フルテキストURL | cted_008_045_057.pdf |
| 著者 | 安藤 美華代| |
| 抄録 | 本研究の目的は，学校運動部活動指導における指導者の心理的負担感と対処について検討することである。対象は，自己記入式質問票に回答した学校運動部活動指導者96人。質的検討を行った結果，指導者は，生徒の態度，保護者からのクレーム，指導者自身の指導力不足，同僚の非協力的態度等を心理的負担に感じていた。生徒や保護者とコミュニケーションを図り信頼関係を構築すること，自己研鑽すること，信頼できる関係者に相談すること等が，対処方略になっていた。心理的負担感を乗り越えた程度と心理社会的要因の関連を検討したところ，心理的負担感を乗り越えたと認識している程度が5割以下の群は，6割以上の群に比べて，有意に抑うつ気分や不安感が高く，健康感や対人関係自己効力感が低かった。以上より，学校運動部活動指導に携わる教員等指導者の心理的負担感を見立て，心理的負担感に対処するこころの健康対策が重要だと考えられた。 |
| キーワード | 学校運動部活動 (school-based extracurricular sports activities) 運動部活動指導者 (coaches of extracurricular sports activities) 心理的負担感 (psychological distress) 対処 (coping) こころの健康 (mental health) |
| 出版物タイトル | 岡山大学教師教育開発センター紀要 |
| 発行日 | 2018-03-20 |
| 巻 | 8巻 |
| 開始ページ | 45 |
| 終了ページ | 57 |
| ISSN | 2186-1323 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2018 岡山大学教師教育開発センター |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/CTED/55804 |
|---|---|
| タイトル（別表記） | Development of Junior High School Home Economics Classes Related to Contact With Infants that Encourages Self-acceptance |
| フルテキストURL | cted_008_015_029.pdf |
| 著者 | 考藤 悦子| 片山 美香| 髙橋 敏之| 西山 修| |
| 抄録 | 中学生の幼児との触れ合い体験の意義については，先行研究によって示されてきたが，体験の何が効果を及ぼしているのか，実証的な研究は未だ少ない。そこで本論では，「他者から受容される経験が，自己受容を促す」との実践的な仮説を立て，触れ合い体験による他者から受容される経験が，自己受容を促す可能性を検討する。触れ合い体験において，幼児は先入観や条件なしに関わってくることが予想される。そのような幼児に受容される体験は，生徒にとって日常的な人間関係とは異なる，得難い経験となり得る。そこを意図的に強化することで，合理的に意義ある授業を作ることが可能となると考える。また，将来の子育てに繋がる，長期的な効果も期待できる。本論では，こうした仮説に基づき，生徒の自己受容に焦点を当て，これを促す中学校家庭科保育領域の授業を開発し報告した。 |
| キーワード | 幼児 (infants) 中学生 (junior high school students) 触れ合い体験 (interactive experiences) 自己受容 (self-acceptance) 授業開発 (development of home economics classes) |
| 出版物タイトル | 岡山大学教師教育開発センター紀要 |
| 発行日 | 2018-03-20 |
| 巻 | 8巻 |
| 開始ページ | 15 |
| 終了ページ | 29 |
| ISSN | 2186-1323 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2018 岡山大学教師教育開発センター |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/fest/55732 |
|---|---|
| フルテキストURL | fest_023_049_079.pdf |
| 著者 | Fumikazu, Ichiminami| Meltem Okur Dinçsoy| Enver Erdin Dinçsoy| |
| 抄録 | There are many limitations and difficulties in terms of expanding agricultural lands. Also, some other factors affect the agricultural lands that result in decreases such as climate change, erosion and misuse of the lands. It is clear that these developments in agricultural land use threaten the future of human welfare, social conditions, economic growth and food supply. In this study, we examined the land use and its significance that represent past agriculture and regional characteristics in the Chugoku region including Okayama prefecture and the Seto Inland Sea. Specifically, among the products called as industrial crops, such as cotton, pyrethrum, rush, tobacco, rapeseed, mulberry and tea, were adopted as the indicators. Currently, these landscapes can hardly be seen, only leaves of tobacco and tea can still be seen in mountainous areas. Even in agricultural land usewhich has almost disappeared now, it may have indirect influence as in the case of reclaimed land and rush products. Therefore, we reaffirmed in this study the reasons for their existence and their significance. |
| キーワード | industrial crop cultivated area rural geography agriculture Okayama prefecture |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 発行日 | 2018-03 |
| 巻 | 23巻 |
| 号 | 1号 |
| 開始ページ | 49 |
| 終了ページ | 79 |
| ISSN | 13419099 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120006414150 |
| JaLCDOI | 10.18926/fest/55730 |
|---|---|
| フルテキストURL | fest_023_001_021.pdf |
| 著者 | Meltem Okur Dinçsoy| Enver Erdinç Dinçsoy| Fumikazu, Ichiminami| |
| 抄録 | The current ratio of dependence on food in Japan has remarkably grown and the significance of food self-sufficiency by concurrent agriculture may decline, while importantly conserving the natural environment, appropriate management of farmland. Okayama prefecture has an agricultural trend over more than 100 years of rice, barley and wheat cropping area with the rise and fall of its agricultural land use from the prior to the Industrial Revolution in Japan. Although rice reduction policy in Japan is scheduled to end in 2017, Japan is strongly subject to rice compared to other grains. In order to understand the role and scope of the agricultural sector in Okayama pref., it is necessary to review the changes in the related agricultural products for the long term. In Okayama pref., the cultivation and processing of some industrial crops including sericulture sector were thriving in the past, but, commercial agriculture was not well developed and the meaning of the production of cereals was greater than current production. Considering the part of agricultural characteristics by examining the cultivation of crops over the long term, planting area survey by variety confirmed that the greatest feature of rice cultivation in Okayama pref. is the diversity of varieties. In addition to various rice varieties, agriculture in Okayama pref. has a high sustainability, resistance and flexibility against changes on climate, policies and land use. |
| キーワード | cultivated area rice wheat barley Okayama prefecture |
| 出版物タイトル | 岡山大学環境理工学部研究報告 |
| 発行日 | 2018-03 |
| 巻 | 23巻 |
| 号 | 1号 |
| 開始ページ | 1 |
| 終了ページ | 21 |
| ISSN | 13419099 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120006414148 |
| JaLCDOI | 10.18926/AMO/55666 |
|---|---|
| フルテキストURL | 72_1_73.pdf |
| 著者 | Umakoshi, Michiari| Yasuhara, Takao| Toyoshima, Atsuhiko| Sasada, Susumu| Kusumegi, Akira| Morimoto, Jun| Kin, Kyohei| Tomita, Yousuke| Date, Isao| |
| 抄録 | The spinal extradural arachnoid cyst is a rare entity. Obtaining the correct diagnosis and detecting the fistula location are critical for providing effective treatment. A 41-year-old man had numbness in the soles of his feet for 2 years with accompanying gait disturbance, and a defecation disorder. Computed tomography myelography performed at another hospital revealed an epidural arachnoid cyst from Th11 to L2. He received a subarachnoid-cyst shunt at the rostral part of the cyst. However, his symptoms worsened and he was admitted to our hospital. Neuroradiological investigations revealed the correct location of the fistula at the level of Th12. We performed partial removal of the cyst wall with fistula closure via right hemilaminectomy of Th11 and 12. The complete closure of the fistula was confirmed by intrathecal infusion of artificial cerebrospinal fluid through the shunt tube. The shunt tube was removed with the sutures. The patient’s symptoms improved, although numbness remained in his bilateral heels. There has been no recurrence in 15 months since the surgery. Fistula closure may work as a balanced therapeutic strategy for spinal extradural arachnoid cyst, and intrathecal cerebrospinal fluid infusion is useful for the confirmation of complete fistula closure. |
| キーワード | fistula closure intrathecal infusion microscopic surgery preoperative evaluation recurrence |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-02 |
| 巻 | 72巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 73 |
| 終了ページ | 76 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29463942 |
| JaLCDOI | 10.18926/AMO/55664 |
|---|---|
| フルテキストURL | 72_1_61.pdf |
| 著者 | Sakamoto, Ai| Kamada, Yasuhiko| Kubo, Kotaro| Hasegawa, Toru| Kotani, Sayoko| Nakatsuka, Mikiya| Hiramatsu, Yuji| |
| 抄録 | Establishing whether miscarriages result from fetal aneuploidy or other factors is important for treating recurrent pregnancy loss. We examined the relationship between fetal heart rate (FHR) before miscarriage in the early first trimester and fetal karyotype, analyzing 223 pregnant women with recurrent pregnancy loss. Among the pregnancies, 110 resulted in live births regarded as normal karyotype (the Norm-group). The other 113 pregnancies ended in miscarriage, and we categorized them into groups based on fetal karyotype, determined by chorionic villus sampling: the Misc-NK (normal karyotype) group, n=35 euploid cases; the Misc-CA1 (chromosomal abnormality) group, n=18 cases of aneuploidy with trisomies 13/18/21, Turner’s syndrome, or Klinefelter’s syndrome; and the Misc-CA2 subgroup, n=60 cases of other aneuploidies excluding those in the Misc-CA1 group. We compared the groups’ regression line slopes and intercepts for FHR by an analysis of covariance. The FHRs of the Norm, Misc-NK and Misc-CA1 groups increased from 36 to 49 days after fertilization, but did not significantly differ across these groups. The Misc-CA2 group’s FHR did not increase and significantly differed from the other three groups (p<0.01). These results suggest that the absence of an increase in FHR in early pregnancy may indicate the presence of chromosomal abnormalities causing miscarriage. |
| キーワード | aneuploidy chorionic villi fetal heart rate recurrent pregnancy loss |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-02 |
| 巻 | 72巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 61 |
| 終了ページ | 66 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29463940 |
| JaLCDOI | 10.18926/AMO/55658 |
|---|---|
| フルテキストURL | 72_2_203.pdf |
| 著者 | Sonekatsu, Mayumi| Sonohata, Motoki| Kitajima, Masaru| Kawano, Shunsuke| Mawatari, Masaaki| |
| 抄録 | In patients with poliomyelitis, degenerative arthritis of the hip may be encountered in the paralytic or normal contralateral limb because of leg length discrepancy, pelvic obliquity, or severe deformities of the affected hip. Although total hip arthroplasty (THA) is one of the most common orthopedic procedures, there are few reports of THA in adult patients with residual poliomyelitis. From March 2001 to January 2011, 5 patients with residual poliomyelitis (6 hips) underwent THA using uncemented implants at our hospital. We retrospectively evaluated the Japanese Orthopedic Association (JOA) hip rating score, complications, and radiographs. All five patients’ follow-up information was available: 4.5 years minimum, 8.4 years average, range 4.5-15 years. Surgery was done at the same side of the paralytic limb in 2 hips and contralateral to the paralytic limb in four hips. All patients had pain relief and improvement in function; JOA hip rating score improved significantly from the mean of 45 preoperatively to 78 at the last follow-up (p=0.0313). There was no loosening or osteolysis in this series, and no cases of dislocation, infection or nerve palsy. These findings can contribute to decisions regarding treatment for arthritic hips in adults with residual poliomyelitis. |
| キーワード | total hip arthroplasty poliomyelitis residual neuromuscular disease complication |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-02 |
| 巻 | 72巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 17 |
| 終了ページ | 22 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29463934 |
| Web of Science KeyUT | 000426542800003 |
| 関連URL | isReplacedBy http://doi.org/10.18926/AMO/55864 |
| JaLCDOI | 10.18926/AMO/55656 |
|---|---|
| フルテキストURL | 72_1_1.pdf |
| 著者 | Saito, Yukihiro| Nakamura, Kazufumi| Ito, Hiroshi| |
| 抄録 | The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases. Commercially available mechanical pacemakers are very useful but still have some problems including short battery life, a risk of infection, the absence of physiological autonomic responsiveness, metal allergy, and electronic interference. A biological pacemaker may resolve these problems and regenerate the cardiac pacemaker. Cell-based therapy and gene therapy have been addressed with the goal of solving the challenges of biological pacemaker. However, the clinical application of a biological pacemaker has not yet been realized. Here we discuss the types of cells that can be used for a biological pacemaker and the problems that remain regarding the clinical applications of cell-based therapy. |
| キーワード | cell therapy pluripotent stem cells cardiomyocytes biological pacemaker hyperpolarization activated cyclic nucleotide gated potassium channel 4 |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-02 |
| 巻 | 72巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 7 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29463932 |
| タイトル（別表記） | Alzheimer’s disease : Relationship between the Alzheimer’s disease and human microbiome |
|---|---|
| フルテキストURL | srfa_107_005_010.pdf |
| 著者 | 藤井 祐介| 森田 英利| |
| 抄録 | Alzheimer’s disease (AD) is a progressive, neurodegenerative disease characterized by memory and language disorder. The accumulation of senile plaques called β-amyloid and neurofibrillary tangles involving protein tau in the brains of AD patients have been considered as two hallmarks of AD. In AD, it is reported that accumulation of β-amyloid may be observed 25 years before onset, supporting early diagnosis and treatment by brain image analysis, because several techniques have recently been developed to detect β-amyloid and tau protein in brains of persons diagnosed with AD. AD patients are usually suffering from other diseases such as diabetes or periodontal disease, and there is accumulating data to show that these diseases associate with the human microbiome, such as gut and oral microbiota. In this report, the relation ship between AD and the human microbiome is reviewed. |
| 出版物タイトル | 岡山大学農学部学術報告 |
| 発行日 | 2018-02-01 |
| 巻 | 107巻 |
| 開始ページ | 5 |
| 終了ページ | 10 |
| ISSN | 2186-7755 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | PhysRevB_93_104508.pdf |
|---|---|
| 著者 | Zheng, Lu| Miao, Xiao| Sakai, Yusuke| Goto, Hidenori| Uesugi, Eri| Eguchi, Ritsuko| Nishiyama, Saki| Sugimoto, Kunihisa| Fujiwara, Akihiko| Kubozono, Yoshihiro| |
| 備考 | This is an article published by American Physical Society| |
| 発行日 | 2016-03 |
| 出版物タイトル | Physical Review B |
| 巻 | 93巻 |
| 号 | 10号 |
| 出版者 | American Physical Society |
| 開始ページ | 104508 |
| ISSN | 2469-9950 |
| NCID | AA11187113 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | American Physical Society |
| 論文のバージョン | publisher |
| DOI | 10.1103/PhysRevB.93.104508 |
| Web of Science KeyUT | 000371732500002 |
| 関連URL | isVersionOf https://doi.org/10.1103/PhysRevB.93.104508 |
| フルテキストURL | PhysRevB_95_245310.pdf |
|---|---|
| 著者 | Uesugi, Eri| Miao, Xiao| Ota, Hiromi| Goto, Hidenori| Kubozono, Yoshihiro| |
| 備考 | This is an article published by American Physical Society| |
| 発行日 | 2017-01 |
| 出版物タイトル | Physical Review B |
| 巻 | 95巻 |
| 号 | 24号 |
| 出版者 | American Physical Society |
| 開始ページ | 245310 |
| ISSN | 2469-9950 |
| NCID | AA11187113 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | American Physical Society |
| 論文のバージョン | publisher |
| DOI | 10.1103/PhysRevB.95.245310 |
| Web of Science KeyUT | 000403355300005 |
| 関連URL | isVersionOf https://doi.org/10.1103/PhysRevB.95.245310 |
| フルテキストURL | PhysRevB_96_094522.pdf |
|---|---|
| 著者 | Nabeta, Masahiro| Tanaka, Kenta K.| Onari, Seiichiro| Ichioka, Masanori| |
| 備考 | This is an article published by American Physical Society| |
| 発行日 | 2017-09 |
| 出版物タイトル | Physical Review B |
| 巻 | 96巻 |
| 号 | 9号 |
| 出版者 | American Physical Society |
| 開始ページ | 094522 |
| NCID | AA11187113 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©2017 American Physical Society |
| 論文のバージョン | publisher |
| DOI | 10.1103/PhysRevB.96.094522 |
| Web of Science KeyUT | 000411161700006 |
| 関連URL | isVersionOf https://doi.org/10.1103/PhysRevB.96.094522 |
| フルテキストURL | GGI_17_5_722.pdf |
|---|---|
| 著者 | Hishikawa, Nozomi| Fukui, Yusuke| Sato, Kota| Yamashita, Toru| Ohta, Yasuyuki| Abe, Koji| |
| キーワード | apparent cognitive decline cognitive/affective functions general population mild cognitive impairment risk factors |
| 備考 | This is an Accepted Manuscript of an article published by Wiley| This fulltext will be available in May 2018| |
| 発行日 | 2017-05 |
| 出版物タイトル | Geriatrics & Gerontology International |
| 巻 | 17巻 |
| 号 | 5号 |
| 出版者 | Japan Geriatrics Society |
| 開始ページ | 722 |
| 終了ページ | 729 |
| ISSN | 1444-1586 |
| NCID | AA1155729X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 27150587 |
| DOI | 10.1111/ggi.12778 |
| Web of Science KeyUT | 000403931900006 |
| 関連URL | isVersionOf https://doi.org/10.1111/ggi.12778 |
| フルテキストURL | GGI_16_4_458.pdf |
|---|---|
| 著者 | Hishikawa, Nozomi| Fukui, Yusuke| Sato, Kota| Kono, Syoichiro| Yamashita, Toru| Ohta, Yasuyuki| Deguchi, Kentaro| Abe, Koji| |
| キーワード | affective functions cognitive function daily living function late-elderly dementia super-aged country |
| 備考 | This is an Accepted Manuscript of an article published by Wiley| |
| 発行日 | 2016-04 |
| 出版物タイトル | Geriatrics & Gerontology International |
| 巻 | 16巻 |
| 号 | 4号 |
| 出版者 | Japan Geriatrics Society |
| 開始ページ | 458 |
| 終了ページ | 465 |
| ISSN | 1444-1586 |
| NCID | AA1155729X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 25952646 |
| DOI | 10.1111/ggi.12492 |
| Web of Science KeyUT | 000373611800007 |
| 関連URL | isVersionOf https://doi.org/10.1111/ggi.12492 |
| JaLCDOI | 10.18926/AMO/55587 |
|---|---|
| フルテキストURL | 71_6_505.pdf |
| 著者 | Honda, Yoshihiro| Takigawa, Nagio| Ichihara, Eiki| Ninomiya, Takashi| Kubo, Toshio| Ochi, Nobuaki| Yasugi, Masayuki| Murakami, Toshi| Yamane, Hiromichi| Tanimoto, Mitsune| Kiura, Katsuyuki| |
| 抄録 | (−)-Epigallocatechin-3-gallate (EGCG) has been shown to bind to several receptors including epidermal growth factor receptor (EGFR). EGFR tyrosine kinase inhibitors and anaplastic lymphoma kinase (ALK) inhibitors are effective for non-small cell lung cancers harboring activating EGFR mutations and ALK or c-ros oncogene 1 (ROS1) fusion genes, respectively. We investigated the effects of EGCG on EGFR- or fusion gene-driven lung cancer cells such as PC-9, RPC-9, H1975, H2228 and HCC78. The five cell lines had similar sensitivity to EGCG. Phosphorylated (p)EGFR, pAkt and pErk in PC-9, RPC-9 and H1975 cells were suppressed by EGCG (50 or 100 μM). EGCG also inhibited pALK in H2228, pROS1 in HCC78, and pErk and pAkt in both cell lines. All the xenograft tumors established using the 5 cell lines in EGCG-treated groups were significantly smaller than the tumors in the vehicle-treated groups. The numbers of tumor blood vessels of xenograft tissues in EGCG-treated mice were significantly lower than those in vehicle-treated mice. In conclusion, EGCG may be effective for EGFR-driven lung tumors irrespective of the presence of T790M, and for ALK or ROS1 fusion gene-driven lung tumors. |
| キーワード | epigallocatechin-3-gallate lung cancer EGFR ALK ROS1 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-12 |
| 巻 | 71巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 505 |
| 終了ページ | 512 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29276223 |
| JaLCDOI | 10.18926/AMO/55586 |
|---|---|
| フルテキストURL | 71_6_493.pdf |
| 著者 | Aoe, Michinori| Ueno-Iio, Tomoe| Shibakura, Misako| Shinohata, Ryoko| Usui, Shinichi| Arao, Yujiro| Ikeda, Satoru| Miyahara, Nobuaki| Tanimoto, Mitsune| Kataoka, Mikio| |
| 抄録 | Lavender essential oil (Lvn) has anti-inflammatory effects in an ovalbumin-sensitized murine model of asthma, and inhibits inflammatory cell infiltration into the lungs. The anti-inflammatory effects of Lvn on cell adhesion molecules are not clear. Here we evaluated the effects of Lvn and its main constituents, linalyl acetate (LA) and linalool (LO), on the expression of tumor necrosis factor-alpha (TNF-α)-induced cell adhesion molecules in murine brain endothelial bEnd.3 cells and human umbilical vein endothelial cells (HUVECs). The bEnd.3 cells were treated with Lvn, LA, or LO and subsequently stimulated with TNF-α. The mRNA expression levels of cell adhesion molecules were detected using RT-PCR. E-selectin and P-selectin protein and phosphorylated-NF-κB p65 were detected by western blotting. The effects of Lvn on HUVECs were measured by RT-PCR. In bEnd.3 cells, Lvn and LA suppressed TNF-α-induced E-selectin, P-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and phosphorylated-NF-κB p65 in the nucleus; LO did not suppress P-selectin or phosphorylated-NF-κB p65. Lvn inhibited TNF-α-induced E-selectin mRNA in HUVECs. These results indicate that Lvn and LA inhibit TNF-α-induced cell adhesion molecules in endothelial cells through the suppression of NF-κB activation. Consequently, Lvn or other essential oils including LA may be useful as alternative anti-inflammatory medicines. |
| キーワード | lavender essential oil linalyl acetate inflammation cell adhesion molecule NF-κB |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-12 |
| 巻 | 71巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 493 |
| 終了ページ | 503 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29276222 |
| JaLCDOI | 10.18926/AMO/55583 |
|---|---|
| フルテキストURL | 71_6_467.pdf |
| 著者 | Obata, Kengo| Yumoto, Tetsuya| Fuke, Soichiro| Tsukahara, Kohei| Naito, Hiromichi| Iida, Atsuyoshi| Takahashi, Tetsuya| Ujike, Yoshihito| Nakao, Atsunori| |
| 抄録 | Early mobilization is advocated to prevent intensive care unit-acquired physical weakness, but the patient's workload and its changes in response to body position changes have not been established. We used indirect calorimetry to determine the energy expenditure (EE) in response to body position changes, and we assessed EE's correlation with respiratory parameters in healthy volunteers: 8 males and 8 females, mean age 23.4±1.3 years. The subjects started in the resting supine position followed by a 30° head-up position, a 60° head-up position, an upright sitting position, a standing position, and the resting supine position. EE was determined in real time by indirect calorimetry monitoring the subject’s respiratory rate, tidal volume (VT), and minute volume (MV). The highest values were observed immediately after the subjects transitioned from standing to supine, and this was significantly higher compared to the original supine position (1,450±285 vs. 2,004±519 kcal/day, p<0.01). Moderate correlations were observed between VT and EE (r=0.609, p<0.001) and between MV and EE (r=0.576, p<0.001). Increasing VT or MV indicates an increasing patient workload during mobilization. Monitoring these parameters may contribute to safe rehabilitation. Further studies should assess EE in critically ill patients. |
| キーワード | early mobilization energy expenditure indirect calorimetry rehabilitation body position |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-12 |
| 巻 | 71巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 467 |
| 終了ページ | 473 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29276219 |
| フルテキストURL | K0005600_other1.pdf |
|---|---|
| 著者 | Takeda, Tatsuaki| Yamamoto, Hiromasa| Kanzaki, Hirotaka| Suzawa, Ken| Yoshioka, Takahiro| Tomida, Shuta| Cui, Xiaojiang| Murali, Ramachandran| Namba, Kei| Sato, Hiroki| Torigoe, Hidejiro| Watanabe, Mototsugu| Shien, Kazuhiko| Soh, Junichi| Asano, Hiroaki| Tsukuda, Kazunori| Kitamura, Yoshihisa| Miyoshi, Shinichiro| Sendo, Toshiaki| Toyooka, Shinichi| |
| 備考 | 学位審査副論文| |
| 発行日 | 2017-02-03 |
| 出版物タイトル | PLoS One |
| 巻 | 12巻 |
| 号 | 2号 |
| 出版者 | Public Library of Science |
| 開始ページ | e0171356 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | publisher |
| PubMed ID | 28158234 |
| DOI | 10.1371/journal.pone.0171356 |
| Web of Science KeyUT | 000396161700064 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0171356 isPartOf http://ousar.lib.okayama-u.ac.jp/55525 |
| フルテキストURL | K0005592_other1.pdf |
|---|---|
| 著者 | Hinamoto, Norikazu| Maeshima, Yohei| Yamasaki, Hiroko| Nasu, Tatsuyo| Saito, Daisuke| Watatani, Hiroyuki| Ujike, Haruyo| Tanabe, Katsuyuki| Masuda, Kana| Arata, Yuka| Sugiyama, Hitoshi| Sato, Yasufumi| Makino, Hirofumi| |
| 備考 | 学位審査副論文| |
| 発行日 | 2014-09-25 |
| 出版物タイトル | Plos One |
| 巻 | 9巻 |
| 号 | 9号 |
| 出版者 | Public Library of Science |
| 開始ページ | e107934 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 論文のバージョン | publisher |
| PubMed ID | 25255225 |
| DOI | 10.1371/journal.pone.0107934 |
| Web of Science KeyUT | 000344862300045 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0107934 isPartOf http://ousar.lib.okayama-u.ac.jp/55517 |