検索結果 - 岡山大学学術成果リポジトリ

Characteristics of the elderly in high - resolution computed tomography lung densitometry

JaLCDOI	10.18926/14787
フルテキストURL	74_026_034.pdf
著者	光廷文裕\| 保崎泰弘\| 芦田耕三\| 岩垣尚史\| 永田拓也\| 藤井誠\| 高田真吾\| 横井正\| 浜田全紀\| 谷崎勝朗\|
抄録	To determine the characteristics of the elderly in high - resolution computed tomography (HRCT) lung densitometry, mean lung density (MLD) and relative area of the lungs showing attenuation values less than -950 HU (RA(950)) on HRCT were evaluated in nonsmoking control subjects (n = 80) and patients with asthma (n = 80) in relation to their age and pulmonary function. MLD was significantly decreased, and RAW was significantly increased with increasing age in both asthmatics and controls. The MLD values were significantly lower in asthmatics compared with controls in subjects aged between 60 and 69 years and over age 70. RAgsov alues were significantly higher in asthmatics compared with controls in subjects aged between 50 and 59 years, between 60 and 69, and over 70. % FEV(1) and FEV(1) / FVC were significantly decreased in elderly asthmatic patients over 70 years of age compared with the values in those under 49. Percent residual volume (% RV) was significantly larger in patients over 70 years of age than in those between 50 and 59, and under 49 years. RAW was significantly larger in patients with steroid-dependent intractable asthma (SDIA) between 50 and 59 years of age, and between 60 and 69 compared with RA 950 in those without SDIA. However, RAW did not differ significantly between SDIA and non-SDIA in patients over age 70. The results suggested that in % LAA of the lungs on HRCT was significantly increased in the elderly subjects with and without asthma, and it was significantly higher in the elderly asthmatics than the elderly controls.
キーワード	aging (加齢) high-resolution computed tomography (高分解能CT) low attenuation area (低吸収域) mean lung density (平均CT値) pulmonary function (肺機能)
出版物タイトル	岡大三朝医療センター研究報告
発行日	2004-02-01
巻	74巻
開始ページ	26
終了ページ	34
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308286

Clinical effects of long-term spa therapy on pulmonaryemphysema. Evaluation by pulmonary function and pathological changes of terminal airspace of the lung

JaLCDOI	10.18926/14783
フルテキストURL	74_011_017.pdf
著者	光延文裕\| 保崎泰弘\| 芦田耕三\| 岩垣尚史\| 永田拓也\| 藤井誠\| 高田真吾\| 横井正\| 浜田全紀\| 谷崎勝朗\|
抄録	Clinical effects of long-term spa therapy for 4 years were estimated in 8 patients of pulmonary emphysema (4 with spa therapy and 4 without spa therapy) by pulmonary function and morphological changes of peripheral airspaces of the lung on high - resolution computed tomography (HRCT). 1 . The values of % FVC, % FEV1.0, and FEV 1.0% did not significantly change for 4year observation both in patients with spa therapy and those without spa therapy. 2. The OLco value significantly decreased from 69.9% at the initial level to 48.8% after 4-year observation in patients without spa therapy (p
キーワード	spa therapy (温泉療法) pulmonary emphysema (,肺気腫) % RV % DLco % low attenuation area of the lung
出版物タイトル	岡大三朝医療センター研究報告
発行日	2004-02-01
巻	74巻
開始ページ	11
終了ページ	17
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308395

Algebraic and Topological Aspects of Rough Set Theory

著者	Milan Vlach\|
発行日	2008-12
出版物タイトル	Proceedings : Fourth International Workshop on Computational Intelligence & Applications
巻	2008巻
号	1号
資料タイプ	会議発表論文

Yawning associated with anterior chest pain in a patient with asthma.

JaLCDOI	10.18926/14773
タイトル（別表記）	’あくび’と胸痛を訴えた気管支喘息の1症例
フルテキストURL	73_081_083.pdf
著者	光延文裕\| 芦田耕三\| 保崎泰弘\| 柘野浩史\| 岡本誠\| 西田典数\| 永田拓也\| 高田真吾\| 谷崎勝朗\|
抄録	We present a case of a patient with asthma who developed yawning associated with anterior chest pain. She was admitted due to severe anterior chest pain, wheezing and dyspnea. Although the frequency of the symptoms decreased, she began to experience frequent episodes of yawning at night accompanied by tears. While she experienced yawning, although PEF (peak expiratory flow) decreased, no asthmatic symptoms, such as wheezing or dyspnea were observed. The yawning was improved markedly by bronchodilators and a leukotriene receptor antagonist, and moderately improved by corticosteroids. We speculated that yawning is a clinical manifestation of asthma that responds to treatment.
キーワード	yawning chest pain nocturnal dyspnea asthma
出版物タイトル	岡大三朝医療センター研究報告
発行日	2003-02-01
巻	73巻
開始ページ	81
終了ページ	83
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308373

Frizzled Activation by Wnt-l Is Required for beta -Catenin -T Cell Factor Dependent Transcription in Esophageal Cancer

JaLCDOI	10.18926/14771
タイトル（別表記）	食道痛細胞におけるWntのベータカテ二ンTCF経路の活性化の検討
フルテキストURL	73_075_080.pdf
著者	水島孝明\| 越智浩二\| 江盛康之\| 谷岡洋亮\| 澤公成\| 藤岡真一\| 真治紀之\| 小出典男\| 谷崎勝朗\|
抄録	Although, accumulation of nuclear and cytoplasmic beta-catenin has been observed in ESCCs, mutation of APC and beta-catenin are not found in ESCCs. Therefore, another mechanism for cytoplasmic beta- catenin accumulation might exist in ESCCs. Materials and Methods: Human ESCCs cell lines and the 293 stable transfectants expressing Wnt-1, Wnt-5A, and Wnt-7A were cultured under standard conditions. The TOPFlash or FOPFlash reporter plasmids were transfected. Results: Transfected mutant beta-catenin as well as an axin fragment harbing the GSK3 beta interaction domain, the latter a potent GSK3 beta inhibitor. both robustly activated pTOPFlash in ESCCs cells. When pTOPFlash/pFOPFlash reporters were transfected in ESCCs cell lines followed by cocultivation with 293 cells that stably express Wnt -1, all cell lines except one demonstrated TCF mediated transcriptional. But, cells were co- cultured, Wnt - 7A or Wnt - 5A did not activate TCF mediated transcription in a cell number dependent fashion. Discussion; We report the activation of TCF promoter gene by extemal Wnt stimuli in ESCCs cells.
キーワード	esophageal carcinoma Wnt TCF beta-catenin
出版物タイトル	岡大三朝医療センター研究報告
発行日	2003-02-01
巻	73巻
開始ページ	75
終了ページ	80
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308224

Effects of spa therapy combined with dietary supplementation with alpha -linolenic acids on bronchial asthma

JaLCDOI	10.18926/14768
タイトル（別表記）	気管支喘息に対する温泉療法とα-リノレン酸強化食の効果
フルテキストURL	73_055_063.pdf
著者	岡本誠\| 芦田耕三\| 光延文裕\| 保崎泰弘\| 柘野浩史\| 西田典数\| 永田拓也\| 横井正\| 高田真吾\| 谷崎勝朗\| 谷本光音\|
抄録	N-3 fatty acids are reportedly effective for asthma. In addition, spa therapy has been reported to be effective for patients with asthma. In the present study, the effects of spa therapy combined with perilla seed oil- rich diet (rich in n-3 fatty acid)were examined on asthma. A total of 14 asthmatic patients had a complex spa therapy and consumed a perilla seed oil- rich diet - rich in a -linolenic acid (alpha-LNA) for 8 weeks. Generation of leukotriene (LT) C4 by leucocytes, respiratory function were analyzed. The generation of LTC4 by leucocytes decreased significantly for 2, 4 and 8 weeks (P
キーワード	bronchial asthma spa therapy perilla seed oil alpha -linolenic acid Leukotriene C4
出版物タイトル	岡大三朝医療センター研究報告
発行日	2003-02-01
巻	73巻
開始ページ	55
終了ページ	63
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308428

Effects of cigarette smoking on IgE-mediated allergy in elderly patients with asthma

JaLCDOI	10.18926/14767
タイトル（別表記）	高齢者喘息のIgEにmediateされるアレルギー反応におよぽす喫煙の影響
フルテキストURL	73_049_054.pdf
著者	芦田耕三\| 光延文裕\| 保崎泰弘\| 柘野浩史\| 西田典数\| 永田拓也\| 高田真吾\| 横井正\| 谷崎勝朗\|
抄録	The influence of cigarette smoking on the pathophysiology of asthma in the elderly remains controversial. In this study, the inluence of cigarette smoking on IgE - mediated allergy including the generation of leukotrienes B4 (LTB4) and C4 (LTC4) was examined in forty asthmatics over the age of 70 years (20 ex-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ex - smokers). The frequency of patients with serum IgE more than 200 IU/ml was significantly larger in smoking asthmatics than in non - smoking asthmatics. The incidence of patients with positive RAST score for inhalant allergens, was also significantly higher in patients with a history of smoking than in those without a smoking history. There were no significant differences in the frequency of patients with positive RAST and those with serum IgE more than 200 IU/ml between non-smoking asthmatics and patients with pulmonary emphysema. The generation of leukotriene B4 (LTB4) by leukocytes was significantly more increased in ex-smokers than in never-smokers in the elderly asthmatics. The results suggest the possibility that cigarette smoking enhances IgE - mediated allergy in elderly patients with asthma.
キーワード	cigarette smoking IgE - mediated allergy LTB4 LTC4 generation elderly asthmatics
出版物タイトル	岡大三朝医療センター研究報告
発行日	2003-02-01
巻	73巻
開始ページ	49
終了ページ	54
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308483

Airflow, the volume and transfer factor of lungs in elderly asthmatics with long-term cigarette smoking

JaLCDOI	10.18926/14766
フルテキストURL	73_044_048.pdf
著者	芦田耕三\| 光延文裕\| 保崎泰弘\| 柘野浩史\| 西田典数\| 永田拓也\| 横井正\| 高田真吾\| 谷崎勝朗\|
抄録	The influence of cigarette smoke on pulmonary function, airflow, lung volume, and transfer factor in patients with asthma was examined in 40 subjects over the age of 70 years (20 ever-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ex-smokers). The ventilatory parameters showing airflow limitation (% FEV(1) and FEV(1)%) were not significantly different between ever-smokers and never-smokers of elderly asthmatics. In contrast, % FEV(1) and FEV(1) % values were significantly lower in patients with pulmonary emphysema than in those with asthma with or without a history of smoking. The % RV value was significantly larger and % DLco value was significantly more decreased in ever-smokers compared with neversmokers of the elderly asthmatics. However, there were no significant differences in % RV and % DLco values between asthmatics with a history of smoking and patients with pulmonary emphysema. The results show that cigarette smoke inflluences % RV and % DLco, but not % FEV(1) and FEV(1) %, suggesting airflow limitation of large and moderate size airways.
キーワード	cigarette smoking FEV(1) % % RV % DLco elderly asthmatics
出版物タイトル	岡大三朝医療センター研究報告
発行日	2003-02-01
巻	73巻
開始ページ	44
終了ページ	48
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308159

Effects of aging on the pathophysiology of asthma obsetved by IgE-mediated allergy, pulmoanry function, low attenuation area of the lungs on HRCT, and LTB4, LTC4 generation

JaLCDOI	10.18926/14764
タイトル（別表記）	lgEにmediatedされるアレルギ反応― 、肺機能、HRCT上の肺のlow attenuatjonarea (LAA)、およびLTB4,LTC4産生から見た喘息の病態に対する加齢の影響
フルテキストURL	73_031_038.pdf
著者	光延文裕\| 芦田耕三\| 保崎泰弘\| 柘野浩史\| 西田典数\| 永田拓也\| 横井正\| 高田真吾\| 谷崎勝朗\|
抄録	The influence of aging on the pathophysiology of asthma in the elderly was examined in 40 patients (20 younger asthmatics under the age of 50 years, mean age 32.5 years and 20 elderly asthmatics over the age of 70 years, mean age 74.3 years), relating to IgE - mediated allergy, pulmonary function, low attenuation area (LAA) of the lungs on HRCT, and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leukocytes. The frequency of patients with serum IgE of more than 200 IU/ml, and the incidence of those with a positive RAST score for inhalant allergens were significantly higher in younger patients than in elderly subjects. The values of % FVC, % FEV1 and FEV 1% were significantly larger in younger patients compared with elderly subjects. The % RV was significantly larger in elderly patients than in younger patients, however, the difference in % DLco was not significant between the two age groups. The LAA of the lungs on HRCT and the ratio of expiratory LAA (exp LAA) to inspiratory LAA (ins LAA) were also significantly larger in elderly asthmatics than in younger subjects. The generation of LTB4 and LTC4 was larger in younger patients than in elderly subjects, and LTB4 generation was significantly larger in younger subjects compared with elderly subjects. These results suggest that changes in IgE-mediated allergy, airflow and lung volume accompanied with hyperinflation are often observed in elderly asthmatics.
キーワード	IgE-mediated allergy pulmonary function elderly asthmatics HRCT % RV
出版物タイトル	岡大三朝医療センター研究報告
発行日	2003-02-01
巻	73巻
開始ページ	31
終了ページ	38
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308601

Nondominated equilibrium solutions of multiobjective two-person nonzero-sum games in normal and extensive forms

著者	Nishizaki Ichiro\|
発行日	2008-12
出版物タイトル	Proceedings : Fourth International Workshop on Computational Intelligence & Applications
巻	2008巻
号	1号
資料タイプ	会議発表論文

Human Error Management Paying Emphasis on Decision Making and Social Intelligence -Beyond the Framework of Man-Machine Interface Design-

著者	村田厚生\|
発行日	2008/12/10
出版物タイトル	Proceedings : Fourth International Workshop on Computational Intelligence & Applications
巻	2008巻
号	1号
資料タイプ	会議発表論文

Cigarette smoking and pathophysiology of asthma and pulmonary emphysema

JaLCDOI	10.18926/14758
タイトル（別表記）	長期間喫煙による気管支唱息,肺気腫の病態的変化
フルテキストURL	075_074_087.pdf
著者	光延文裕\| 保崎泰弘\| 芦田耕三\| 濱田全紀\| 岩垣尚史\| 藤井誠\| 高田真吾\| 谷崎勝朗\|
抄録	The influence of long-term cigarette smoking on the pathophysiology of chronic respiratory diseases with obstructive ventilatory dysfunction was discussed in patients with asthma and pulmonary emphysema (PE). 1. In patients with asthma, significant differences in the pathophysiology of the disease were observed between smokers and nonsmokers. A positive RAST score against inhalant allergens, bronchial hyperresponsiveness, and LTB4 generation by leucocytes were significantly more increased in smokers than in nonsmokers. The values of FEV1/FVC and OLco were significantly more decreased, and % RV was significantly more increased in smokers than in nonsmokers. 2. In comparison of asthma with PE, IgE-mediated allergy was significantly more increased in smokers with asthma than in nonsmokers with asthma and in smokers with PE. The values of % FEV1, FEVl %, and % OLco were significantly higher in nonsmokers with asthma than in smokers with PE, however, the % OLco and % RV were not significantly different between smokers with asthma and those with PE. The % LAA of the lungs on HRCT was larger in patients with PE than in smokers and nonsmokers with asthma. The results suggest that cigarette smoking influences the pathophysiology of asthma and PE.
キーワード	cigarette smoking (喫煙) pulmonary function (肺機能) hyperinflation (肺の過膨張) asthma (喘息) pulmonary emphysema (肺気腫)
出版物タイトル	岡大三朝医療センター研究報告
発行日	2004-12-01
巻	75巻
開始ページ	74
終了ページ	87
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308631

An increase in bronchial hyperresponsiveness by cigarette smoking in elderly patients with asthma

JaLCDOI	10.18926/14755
タイトル（別表記）	高齢者喘息における喫煙による気道過敏性の亢進について
フルテキストURL	73_025_030.pdf
著者	光延文裕\| 保﨑泰弘\| 芦田耕三\| 柘野浩史\| 西田典数\| 永田拓也\| 高田真吾\| 横井正\| 谷崎勝朗\|
抄録	Influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study was undertaken to clarify the influence of cigarette smoking on IgE-mediated allergy, bronchial hyperresponsiveness, and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leukocytes in 48 elderly patients (25 patients with a history of smoking for more than 20 years and 23 never-smokers) with asthma over the age of 70 years. 1. The incidence of positive IgE antibodies for inhalant allergens was significantly higher in asthmatics with a history of smoking than in never-smokers of asthmatics. 2. In bronchial hyperresponsiveness for methacholine, the Cmin was significantly lower in ever-smokers than in never-smokers of elderly asthmatics. 3. The generation of LB4 was significantly increased in patients with a history of smoking compared with those without a smoking history. However, the difference in LTC4 generation was not significant between ever-smokers and never-smokers of asthmatics. These results suggest that cigarette smoking increases bronchial hyperresponsiceness through IgE-mediated allergy and LTB4 generation.
キーワード	cigarette smoking IgE - mediated allergy elderly asthmatics bronchial hyperresponsiveness
出版物タイトル	岡大三朝医療センター研究報告
発行日	2003-02-01
巻	73巻
開始ページ	25
終了ページ	30
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308038

Effects of spa therapy on reduction of the costs of the drugs used for the treatment of asthma in the elderly in relation to disease severity

JaLCDOI	10.18926/14754
タイトル（別表記）	温泉療法による気管支喘息に対する年間薬剤費の削減
フルテキストURL	075_045_052.pdf
著者	芦田耕三\| 光延文裕\| 保崎泰弘\| 濱田全紀\| 岩垣尚史\| 藤井誠\| 高田真吾\| 谷崎勝朗\|
抄録	Costs of drugs used for the treatment for 1 year were compared before and after spa therapy in 16 patients with asthma in relation to disease severity. Asthma severity was classified as : stage 1 (intermittent), 2 (mild persistent), 3(moderate persistent), and 4(severe persistent). 1. The total cost of drugs used for each pa-tient for 1 year clearty decreased in all groups. The % decrease of the costs of drugs in each group was 27.2% in patients with stage 1, 43.5% in those with stage 2 and 34.1% in those with stage 3-4 (mean 34.5% ). The reduction of the cost of bronchodilators was predominant in patients with stage 3-4, and the decrease in the cost of corticosteroids predominant in those with stage 2. The reduction of costs of antiallertgics, mucolytics, and antibiotics was predominant in patients with stage 2 and stage 3-4. The % reduction in the cost of corticostroids was remarkable in patients with stage 2. The % decrease in the costs of mucolytics and antibiotics was predomi-nant in patients with stage 2 and stage 3-4. The results obtained here suggest that the costs of drugs used for asthmatics could be reduced by long-term spa therapy, and the reduction of the costs was larger as asthma stage became more severe.
キーワード	asthma spa therapy costs bronchodilators corticostreroids antiallergics
出版物タイトル	岡大三朝医療センター研究報告
発行日	2004-12-01
巻	75巻
開始ページ	45
終了ページ	52
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308608

Long-term cigarette smoking influences low attenuation area of the lungs on high-resolution CT in elderly patients with asthma, compared with pulmonary emphysema.

JaLCDOI	10.18926/14753
タイトル（別表記）	高齢者喘息における HRCT 上の肺の low attenuation area (LAA) に及ぼす長期間喫煙の影響．肺気腫症例との比較．
フルテキストURL	73_019_024.pdf
著者	光延文裕\| 保﨑泰弘\| 芦田耕三\| 柘野浩史\| 西田典数\| 永田拓也\| 高田真吾\| 横井正\| 谷崎勝朗\|
抄録	The influence of cigarette smoking on the pathophysiology in elderly patients with asthma. Forty asthmatics over the age of 70 years (20 ex-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ever-smokers) were studied to determine the influence of cigarette smoke on the low attenuation area (LAA) <-950 HU (RA950) of the lungs on high resolution CT (HRCT) scans, and the ratio of expiratory LAA to inspiratory LAA of the lungs in relation to pulmonary function. The LAA value was significantly higher in patients with pulmonary emphysema compared with ever-smokers of asthmatics. The LAA ratio was significantly higher in ever-smokers than in never-smokers of asthmatics, and the ratio was less than 0.5 in all never-smokers, and the ratio was more than 0.5 in 10 of 20 ever-smokers of asthmatics and in all patients with pulmonary emphysema. The % RV (residual volume) was significaltly larger and % DLco (diffusing capacity for carbon monoxide) was significantly lower in subjects with the ratio more than 0.5 than in those with the ratio less than 0.5. These results suggest that cigarette smoke influences LAA of the lungs in relation to % RV value and % DLco value.
キーワード	cigarette smoking high resolution CT % RV % DLco elderly asthmatics
出版物タイトル	岡大三朝医療センター研究報告
発行日	2003-02-01
巻	73巻
開始ページ	19
終了ページ	24
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308216

Enhanced leukotriene generation adn bronchial hyperresponsiveness in asthmatics with allergic rhinitis

JaLCDOI	10.18926/14752
タイトル（別表記）	アルルギー性鼻炎を合併したアトピー性喘息患者におけるロイコトリエン産生能と気道過敏性
フルテキストURL	075_037_044.pdf
著者	光延文裕\| 保崎泰弘\| 芦田耕三\| 岩垣尚史\| 藤井誠\| 高田真吾\| 濱田全紀\| 谷崎勝朗\|
抄録	Rhinitis frequently precedes asthma, and treating allergic rhinitis has benefi-cial effects on asthma, suggesting upper airway disease ia a risk factor for asthma. The aim of the present study was to investigate the influence of allergic rhinitis on se-rum IgE level, leukotriene generation by peripheral leukocytes, and bronchial hyperresponsiveness (BHR) to methacholine in patients with atopic asthma. Seventy-one asthmatic subjects (mean age, 59.5±12.5, years ; 37 women, 34 men) were recruited, and 48 asthmatics had allergic rhinitis and 23 asthmatics did not have allergic rhinitis. The log10 (Dmin) was significantly lower for those with allergic rhinitis than those with-out allergic rhinitis (P<0.05), implying that those with allergic rhinitis developed BHR to a greater degree than those without allergic rhinitis. LTC4 generation from periph-eral leukocytes was significantly greater for atopic astmatics with allergic rhinitis than those without allergic rhinitis (p<0.05). In contrast, the amount of LTB4 produced from peripheral leukocytes did not significantly differ between asthmatic patients with and without allergic rhinitis. These results suggest that the presence of allergic rhinitis enhances BHR by enhancing LTC4 production. while the presence of allergic rhinitis did not affect LTB4 production in patients with atopic asthma.
キーワード	asthma (気管支喘息) allergic rhinitis (アレルギー性鼻炎) leukotriene generation (ロイコトリエン産性能) bronchial hyperresponsiveness (気道過敏性)
出版物タイトル	岡大三朝医療センター研究報告
発行日	2004-12-01
巻	75巻
開始ページ	37
終了ページ	44
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308204

Comparison of pathophysiological changes of asthma between younger and older patients with asthma in relation to long-term cigarette smoking

JaLCDOI	10.18926/14751
タイトル（別表記）	気管支喘息における長期間喫煙による病態的変化の若年者と高齢者の比較
フルテキストURL	075_027_036.pdf
著者	光延文裕\| 保崎泰弘\| 芦田耕三\| 濱田全紀\| 岩垣尚史\| 藤井誠\| 高田真吾\| 谷崎勝朗\|
抄録	Influence of long-term clgarette smoking on the paphophysiological changes of the disease was compared between younger and older patients with asthma. 1. The frequency of positive RAST score against inhalant allergens was significantly higher in ex-smokers than in never-smokers in older patients with astham, but not in younger subjects. 2. Ventilatory parameters such as % FVC and FEV 1.0% were not sig-nificantly different between ex-smokers and never-smokers either in younger or older patients, although a significant difference in these values was observed between younger and older subjects. 3. The % DLco was significantly lower in ex-smokers than in never-smokers both in yonger and older patients. 4. The parameters associated with hyperinflation asuch as % RV and % LAA of the lungs on HRCT were significantly higher in older patients than in younger subjects, and also significantly larger in ex-smokers than in never-smokers in older patients, but % RV was not different between ex-smokers and never-smokers in young subjects. 5. Bronchial hyperresponsiveness (BH) was significantly more increased in ex-smokers than in never-smokers in older patients, but not in younger subjects. There was a significant difference in BH be-tween younger and older patients. 6. LTB4 generation was significantly larger in ex-smokers than in never-smokers in older patients, and LTC4 generation was more in-creased in ex-smokers both in younger and older subjects. The results show that significant differences between ex-smokers and never-smokers were observed in % DLco, LTC4 generation and % LAA both in younger and older subjects, and in IgE an-tibodies production, % RV, BH and LTB4 generation only in older subjects. In contrast, the values of % FVC and FEV1.0% were not different between ex-smokers and never-smok-ers either in younger or older subjects. A significant difference between younger and older subjects was found in all other parameters except % DLco and LTC4 generation.
キーワード	cigarette smoking % RV % LAA of he lungs on HRCT asthma bronchial hyperresponsiveness
出版物タイトル	岡大三朝医療センター研究報告
発行日	2004-12-01
巻	75巻
開始ページ	27
終了ページ	36
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308352

Influence of long-term cigarette smoking on changes of lung density by high-resolution computed tomography in asthmatics--4 years follow-up study

JaLCDOI	10.18926/14750
タイトル（別表記）	気管支喘息の low attenuation are (LAA) に対する長期喫煙の影響-4年間の経過観察-
フルテキストURL	73_010_018.pdf
著者	光延文裕\| 芦田耕三\| 保﨑泰弘\| 柘野浩史\| 岡本誠\| 西田典数\| 永田拓也\| 高田真吾\| 横井正\| 中井睦郎\| 谷崎勝朗\| 谷本光音\|
抄録	Background-The influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study attempts to estimate longitudinal changes in HRCT (high resolution computed tomography) parameters and pulmonary function parameters obtained for ex-smokers and never-smokers in asthmatics during 4-yr follow-up period. Methods-Fourteen asthmatics (6 ex-smokers and 8 never-smokers) were studied to determine the influence of aging and cigarette smoking on pulmonary function, and mean lung density (MLD) and the relative area of the lung showing attenuation values less than -950 HU (RA950) on HRCT scans. Results-The values of FVC and FEV1, were significantly more decreased in asthmatics without a smoking history during 4-yr follow-up period. The values of FVC, FEV1, FEV1/FVC and DLco/VA were significantly decreased and RV/TLC were significantly increased in asthmatics with a smoking history over 4 years, and annual decline in FEV1 ex-smokers was larger than that in never-smokers. In the upper lung field, inspiratory MLD was observed to shift in a negative direction and inspiratory RA950 was found to increase during 4-yr observation period in ex-smokers, but not in never-smokers. In the middle lung field, inspiratory RA950 was significantly enhanced in both two groups. Although expiratory MLD, expiratory RA950 and exp RA950/ins RA950 were observed to change significantly during the observation period in ex-smokers, no changes were observed in never-smokers. Conclusion-These results suggest that aging augments airspace enlargement predominantly in the middle lung field, while long term cigarette smoking further worsens emphysematous alterations in the upper lung field.
キーワード	lung density high resolution computed tomography asthma
出版物タイトル	岡大三朝医療センター研究報告
発行日	2003-02-01
巻	73巻
開始ページ	10
終了ページ	18
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308656

Spa therapy and bronchial hyperresponsiveness associated with cigarette smoking in asthmantics in the elderly

JaLCDOI	10.18926/14749
タイトル（別表記）	高齢者気管支喘息における喫煙による気道過敏性の亢進と温泉療法の臨床効果
フルテキストURL	075_018_026.pdf
著者	光延文裕\| 保崎泰弘\| 芦田耕三\| 岩垣尚史\| 藤井誠\| 高田真吾\| 濱田全紀\| 谷崎勝朗\|
抄録	Clinical effects of spa therapy were examined in 60 elderly asthmatics in comparison between ex-smokers with a long history of cigarette smoking more than 20 years and never-smokers. Spa therapy wse effective in 47 of the 60 subjects (78.4%) with asthma. Ragarding in influence of cigarette smoking, the therapy was effective in 16 of the 24 astmatics (66.7%) with a long history of cigarette smoking. In con-trast, the therapy was effective in 31 of the 36 asthmatics (86.1%) withput smoking history. The spa efficacy was significantly larger in asthmatics without smoking history than those with (P<0.05). There was no significant correlation between spa efficacy and IgE-mediated reactions. Bronchial hyperresponsiveness was significantly higher in subjects with slight or no efficacy of spa therapy than in those with marked and mod-erate efficacy both in ex-smokers and never-smokers as well as in total subjects. The generation of leukotriene B4 (LTB4) by leucocytes was significantly increased in sub-jects with slight or no efficacy of spa therapy than in those with marked and moderate efficacy in total subjects and in those with smoking history, but not in those without smoking history. The generation of leukotriene C4 (LTC4) by leucocytes was not sig-nificantly correlated with spa efficacy in total subjects, and also either in ex-smokers or never-smokers. The results demonstrate that clinical effects of spa therapy are in-fluenced by long-term cigarette smoking, which increases bronchial hyperrespon-siveness and the generation of LTB4 by leucocytes.
キーワード	cigarette smoking spa therapy elderly asthmatics bronchial hyperresponsiveness
出版物タイトル	岡大三朝医療センター研究報告
発行日	2004-12-01
巻	75巻
開始ページ	18
終了ページ	26
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308545

Costs of drugd used for the treatment of asthma in relation to disease severity

JaLCDOI	10.18926/14748
タイトル（別表記）	気管支喘息に対する年間薬剤費の重症度別検討
フルテキストURL	075_012_017.pdf
著者	谷崎勝朗\| 光延文裕\| 保崎泰弘\| 芦田耕三\| 濱田全紀\| 岩垣尚史\| 藤井誠\| 高田真吾\|
抄録	Costs of drugs used for the treatment for 1 year were examined in 32 pa-tients with asthma in relation to disease severity. Asthma severity was classified as : 1) intermiitent; 2) mild persistent; 3) moderate persistent; 4) severe persistent. 1. The total cost of drugs used for each patient for 1 year was the highest (￥263,710) in patients of stage 4 (severe persistent) and the lowest (￥74,670) in those of stage 1 (intermittent). The costs of bronchodilators and antiallergics were predominant at all stages, and their cost increased significantly with increasing severity. 2. The costs of drugs such as antiallergics and bronchodilators were predominant, and the costs of drugs such as inhaled corticosteroids and mucolytics were considerably high in pa-tients of all stages. 3. The costs of bronchodilators, inhaled corticosteroids, and antiallergics were the largest in patients of stage 4. The results suggested that the costs of durgs used for the asthma treatment tended to increase as the disease sever-ity became stronger from stage 1 to stage 4, and the maln drugs related to the in-crease in total costs were bronchodilators, antiallergics, and inhaled corticosteroids.
キーワード	asthma disease severity costs bronchodilators corticostreroids antiallergics
出版物タイトル	岡大三朝医療センター研究報告
発行日	2004-12-01
巻	75巻
開始ページ	12
終了ページ	17
ISSN	1348-1258
言語	英語
論文のバージョン	publisher
NAID	120002308112