start-ver=1.4
cd-journal=joma
no-vol=2024
cd-vols=
no-issue=12
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Multi-dimensional optimisation of the scanning strategy for the LiteBIRD space mission
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Large angular scale surveys in the absence of atmosphere are essential for measuring the primordial B-mode power spectrum of the Cosmic Microwave Background (CMB). Since this proposed measurement is about three to four orders of magnitude fainter than the temperature anisotropies of the CMB, in-flight calibration of the instruments and active suppression of systematic effects are crucial. We investigate the effect of changing the parameters of the scanning strategy on the in-flight calibration effectiveness, the suppression of the systematic effects themselves, and the ability to distinguish systematic effects by null-tests. Next-generation missions such as LiteBIRD, modulated by a Half-Wave Plate (HWP), will be able to observe polarisation using a single detector, eliminating the need to combine several detectors to measure polarisation, as done in many previous experiments and hence avoiding the consequent systematic effects. While the HWP is expected to suppress many systematic effects, some of them will remain. We use an analytical approach to comprehensively address the mitigation of these systematic effects and identify the characteristics of scanning strategies that are the most effective for implementing a variety of calibration strategies in the multi-dimensional space of common spacecraft scan parameters. We verify that LiteBIRD's standard configuration yields good performance on the metrics we studied. We also present Falcons.jl, a fast spacecraft scanning simulator that we developed to investigate this scanning parameter space.
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en-aut-name=TomasiM.
en-aut-sei=Tomasi
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=99
ORCID=
en-aut-name=TristramM.
en-aut-sei=Tristram
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=100
ORCID=
en-aut-name=van TentB.
en-aut-sei=van Tent
en-aut-mei=B.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=101
ORCID=
en-aut-name=VielvaP.
en-aut-sei=Vielva
en-aut-mei=P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=102
ORCID=
en-aut-name=WehusI.K.
en-aut-sei=Wehus
en-aut-mei=I.K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=103
ORCID=
en-aut-name=WestbrookB.
en-aut-sei=Westbrook
en-aut-mei=B.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=104
ORCID=
en-aut-name=Weymann-DespresG.
en-aut-sei=Weymann-Despres
en-aut-mei=G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=105
ORCID=
en-aut-name=WollackE.J.
en-aut-sei=Wollack
en-aut-mei=E.J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=106
ORCID=
en-aut-name=ZannoniM.
en-aut-sei=Zannoni
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=107
ORCID=
en-aut-name=ZhouY.
en-aut-sei=Zhou
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=108
ORCID=
affil-num=1
en-affil=Okayama University, Department of Physics
kn-affil=
affil-num=2
en-affil=International School for Advanced Studies (SISSA)
kn-affil=
affil-num=3
en-affil=Okayama University, Department of Physics
kn-affil=
affil-num=4
en-affil=ILANCE, CNRS, University of Tokyo International Research Laboratory
kn-affil=
affil-num=5
en-affil=IRAP, Université de Toulouse, CNRS, CNES, UPS
kn-affil=
affil-num=6
en-affil=Okayama University, Department of Physics
kn-affil=
affil-num=7
en-affil=Okayama University, Department of Physics
kn-affil=
affil-num=8
en-affil=Okayama University, Department of Physics
kn-affil=
affil-num=9
en-affil=Université Paris Cité, CNRS, Astroparticule et Cosmologie
kn-affil=
affil-num=10
en-affil=IRAP, Université de Toulouse, CNRS, CNES, UPS
kn-affil=
affil-num=11
en-affil=The University of Tokyo, Department of Physics
kn-affil=
affil-num=12
en-affil=Dipartimento di Fisica, Università di Roma Tor Vergata
kn-affil=
affil-num=13
en-affil=International School for Advanced Studies (SISSA)
kn-affil=
affil-num=14
en-affil=Dipartimento di Fisica e Scienze della Terra, Università di Ferrara
kn-affil=
affil-num=15
en-affil=IRAP, Université de Toulouse, CNRS, CNES, UPS
kn-affil=
affil-num=16
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=
affil-num=17
en-affil=Dipartimento di Fisica e Astronomia "G. Galilei", Università degli Studi di Padova
kn-affil=
affil-num=18
en-affil=School of Physics, Indian Institute of Science Education and Research Thiruvananthapuram
kn-affil=
affil-num=19
en-affil=Dipartimento di Fisica, Università degli Studi di Milano
kn-affil=
affil-num=20
en-affil=Dipartimento di Fisica e Scienze della Terra, Università di Ferrara
kn-affil=
affil-num=21
en-affil=Dipartimento di Fisica e Scienze della Terra, Università di Ferrara
kn-affil=
affil-num=22
en-affil=School of Physics and Astronomy, Cardiff University
kn-affil=
affil-num=23
en-affil=INFN Sezione di Ferrara
kn-affil=
affil-num=24
en-affil=IRAP, Université de Toulouse, CNRS, CNES, UPS
kn-affil=
affil-num=25
en-affil=International School for Advanced Studies (SISSA)
kn-affil=
affil-num=26
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=
affil-num=27
en-affil=Jodrell Bank Centre for Astrophysics, Department of Physics and Astronomy, School of Natural Sciences, The University of Manchester
kn-affil=
affil-num=28
en-affil=Centre Spatial de Liège, Université de Liège
kn-affil=
affil-num=29
en-affil=Dipartimento di Fisica, Università La Sapienza
kn-affil=
affil-num=30
en-affil=Dipartimento di Fisica, Università La Sapienza
kn-affil=
affil-num=31
en-affil=INAF, OAS Bologna
kn-affil=
affil-num=32
en-affil=Dipartimento di Fisica, Università La Sapienza
kn-affil=
affil-num=33
en-affil=Dipartimento di Fisica, Università La Sapienza
kn-affil=
affil-num=34
en-affil=Institute of Particle and Nuclear Studies (IPNS), High Energy Accelerator Research Organization (KEK)
kn-affil=
affil-num=35
en-affil=CNRS-UCB International Research Laboratory, Centre Pierre Binétruy, UMI2007
kn-affil=
affil-num=36
en-affil=INFN Sezione Milano Bicocca
kn-affil=
affil-num=37
en-affil=Max Planck Institute for Astrophysics
kn-affil=
affil-num=38
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=
affil-num=39
en-affil=Université Paris Cité, CNRS, Astroparticule et Cosmologie
kn-affil=
affil-num=40
en-affil=INAF, OAS Bologna
kn-affil=
affil-num=41
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=
affil-num=42
en-affil=Dipartimento di Fisica e Scienze della Terra, Università di Ferrara
kn-affil=
affil-num=43
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=
affil-num=44
en-affil=University of Milano Bicocca, Physics Department
kn-affil=
affil-num=45
en-affil=International Center for Quantum-field Measurement Systems for Studies of the Universe and Particles (QUP), High Energy Accelerator Research Organization (KEK)
kn-affil=
affil-num=46
en-affil=School of Physics and Astronomy, Cardiff University
kn-affil=
affil-num=47
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=
affil-num=48
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=
affil-num=49
en-affil=Instituto de Astrofísica de Canarias
kn-affil=
affil-num=50
en-affil=INAF, OAS Bologna
kn-affil=
affil-num=51
en-affil=International Center for Quantum-field Measurement Systems for Studies of the Universe and Particles (QUP), High Energy Accelerator Research Organization (KEK)
kn-affil=
affil-num=52
en-affil=Université Paris-Saclay, CNRS/IN2P3, IJCLab
kn-affil=
affil-num=53
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=
affil-num=54
en-affil=Okayama University, Department of Physics
kn-affil=
affil-num=55
en-affil=Institute of Particle and Nuclear Studies (IPNS), High Energy Accelerator Research Organization (KEK)
kn-affil=
affil-num=56
en-affil=Dipartimento di Fisica, Università La Sapienza
kn-affil=
affil-num=57
en-affil=INFN Sezione di Ferrara
kn-affil=
affil-num=58
en-affil=Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), UTIAS, The University of Tokyo
kn-affil=
affil-num=59
en-affil=Dipartimento di Fisica e Scienze della Terra, Università di Ferrara
kn-affil=
affil-num=60
en-affil=Laboratoire de Physique de l'École Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université de Paris
kn-affil=
affil-num=61
en-affil=University of California, San Diego, Department of Physics
kn-affil=
affil-num=62
en-affil=Aurora Technology for the European Space Agency
kn-affil=
affil-num=63
en-affil=Space Science Data Center, Italian Space Agency
kn-affil=
affil-num=64
en-affil=Université Paris-Saclay, CNRS, Institut d'Astrophysique Spatiale
kn-affil=
affil-num=65
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=
affil-num=66
en-affil=Dipartimento di Fisica, Università La Sapienza
kn-affil=
affil-num=67
en-affil=Dipartimento di Fisica e Astronomia "G. Galilei", Università degli Studi di Padova
kn-affil=
affil-num=68
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=
affil-num=69
en-affil=Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), UTIAS, The University of Tokyo
kn-affil=
affil-num=70
en-affil=Dipartimento di Fisica, Università La Sapienza
kn-affil=
affil-num=71
en-affil=Dipartimento di Fisica, Università di Roma Tor Vergata
kn-affil=
affil-num=72
en-affil=Max Planck Institute for Astrophysics
kn-affil=
affil-num=73
en-affil=INAF, OAS Bologna
kn-affil=
affil-num=74
en-affil=IRAP, Université de Toulouse, CNRS, CNES, UPS
kn-affil=
affil-num=75
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=
affil-num=76
en-affil=Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), UTIAS, The University of Tokyo
kn-affil=
affil-num=77
en-affil=Dipartimento di Fisica, Università La Sapienza
kn-affil=
affil-num=78
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=
affil-num=79
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=
affil-num=80
en-affil=Okayama University, Department of Physics
kn-affil=
affil-num=81
en-affil=Dipartimento di Fisica e Scienze della Terra, Università di Ferrara
kn-affil=
affil-num=82
en-affil=INAF, OAS Bologna
kn-affil=
affil-num=83
en-affil=Dipartimento di Fisica, Università La Sapienza
kn-affil=
affil-num=84
en-affil=INFN Sezione di Pisa
kn-affil=
affil-num=85
en-affil=Space Science Data Center, Italian Space Agency
kn-affil=
affil-num=86
en-affil=Istituto Nazionale di Fisica Nucleare-aboratori Nazionali di Frascati (INFN-LNF)
kn-affil=
affil-num=87
en-affil=Dipartimento di Fisica e Scienze della Terra, Università di Ferrara
kn-affil=
affil-num=88
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=
affil-num=89
en-affil=Dipartimento di Fisica, Università di Roma Tor Vergata
kn-affil=
affil-num=90
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=
affil-num=91
en-affil=Suwa University of Science
kn-affil=
affil-num=92
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=
affil-num=93
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=
affil-num=94
en-affil=Suwa University of Science
kn-affil=
affil-num=95
en-affil=Dipartimento di Fisica, Università di Pisa
kn-affil=
affil-num=96
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=
affil-num=97
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=
affil-num=98
en-affil=INAF, OAS Bologna
kn-affil=
affil-num=99
en-affil=Dipartimento di Fisica, Università degli Studi di Milano
kn-affil=
affil-num=100
en-affil=Université Paris-Saclay, CNRS/IN2P3, IJCLab
kn-affil=
affil-num=101
en-affil=Université Paris-Saclay, CNRS/IN2P3, IJCLab
kn-affil=
affil-num=102
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=
affil-num=103
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=
affil-num=104
en-affil=University of California, Berkeley, Department of Physics, Berkeley
kn-affil=
affil-num=105
en-affil=Université Paris-Saclay, CNRS/IN2P3, IJCLab
kn-affil=
affil-num=106
en-affil=NASA Goddard Space Flight Center
kn-affil=
affil-num=107
en-affil=University of Milano Bicocca, Physics Department
kn-affil=
affil-num=108
en-affil=International Center for Quantum-field Measurement Systems for Studies of the Universe and Particles (QUP), High Energy Accelerator Research Organization (KEK)
kn-affil=
en-keyword=CMBR experiments
kn-keyword=CMBR experiments
en-keyword=CMBR polarisation
kn-keyword=CMBR polarisation
en-keyword=gravitational waves and CMBR polarization
kn-keyword=gravitational waves and CMBR polarization
END
start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=6
article-no=
start-page=459
end-page=464
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Traumatic Neuroma Arising from Surgical Trauma during Conversion from Laparoscopic to Open Cholecystectomy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Traumatic neuroma is an abnormal proliferation of injured nerves resulting from trauma or surgery. We present a case of traumatic neuroma arising in the cystic duct after cholecystectomy. A 66-year-old man was referred to our department due to a biliary tumor. He had undergone cholecystectomy 20 years prior. Cholangioscopy showed an elevated lesion covered with smooth mucosa. Histological examination revealed normal bile duct mucosa. Although benign disease was suspected, the possibilities of malignant disease could not be excluded. Extrahepatic bile duct resection was planned to include intraoperative rapid-freezing of a biopsy specimen followed by histopathological examination. These intraoperative histology results showed proliferation of nerve and fibrous tissue only, resulting in the diagnosis of traumatic neuroma, so no lymph nodes were removed. To avoid excessive surgical intervention, histopathological examination of an intraoperative rapid-frozen biopsy specimen may be important for diagnosing traumatic neuroma.
en-copyright=
kn-copyright=
en-aut-name=SakamotoShinya
en-aut-sei=Sakamoto
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TabuchiMotoyasu
en-aut-sei=Tabuchi
en-aut-mei=Motoyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YoshimatsuRika
en-aut-sei=Yoshimatsu
en-aut-mei=Rika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MatsumotoManabu
en-aut-sei=Matsumoto
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=IwataJun
en-aut-sei=Iwata
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=OkabayashiTakehiro
en-aut-sei=Okabayashi
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=
affil-num=2
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=
affil-num=3
en-affil=Department of Radiology, Kochi Health Sciences Center
kn-affil=
affil-num=4
en-affil=Department of Diagnostic Pathology, Kochi Health Sciences Center
kn-affil=
affil-num=5
en-affil=Department of Diagnostic Pathology, Kochi Health Sciences Center
kn-affil=
affil-num=6
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=
en-keyword=traumatic neuroma
kn-keyword=traumatic neuroma
en-keyword=biliary stricture
kn-keyword=biliary stricture
en-keyword=cholecystectomy
kn-keyword=cholecystectomy
en-keyword=cholangiography
kn-keyword=cholangiography
en-keyword=intraoperative rapid-frozen biopsy
kn-keyword=intraoperative rapid-frozen biopsy
END
start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=6
article-no=
start-page=453
end-page=458
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Case of Radiation-Induced Angiosarcoma after Breast-Conserving Surgery with Hypofractionated Radiotherapy in a Japanese Patient
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radiation-induced angiosarcoma (RIAS) is a rare, late adverse event of radiotherapy comprising approximately half of all radiation-induced sarcomas. It has a relatively short latency period and generally unfavorable prognosis. This study presents a case of RIAS that developed 5 years and 11 months after the completion of hypofractionated radiotherapy (42.56 Gy/16 fractions) following partial mastectomy. The patient was diagnosed with RIAS 10 months after the onset of skin redness. She underwent skin tumor resection, followed by paclitaxel, then pazopanib administration, but no radiotherapy. At 6 years and 2 months after surgery, no RIAS recurrence has been detected.
en-copyright=
kn-copyright=
en-aut-name=KawataYujiro
en-aut-sei=Kawata
en-aut-mei=Yujiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=WatanabeKenta
en-aut-sei=Watanabe
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=TokiyaRyoji
en-aut-sei=Tokiya
en-aut-mei=Ryoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MatsunoTakeshi
en-aut-sei=Matsuno
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=TanakaRyo
en-aut-sei=Tanaka
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TairaNaruto
en-aut-sei=Taira
en-aut-mei=Naruto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KatsuiKuniaki
en-aut-sei=Katsui
en-aut-mei=Kuniaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=Department of Radiology, Kawasaki Medical School
kn-affil=
affil-num=2
en-affil=Department of Radiology, Kawasaki Medical School
kn-affil=
affil-num=3
en-affil=Department of Radiology, Kawasaki Medical School
kn-affil=
affil-num=4
en-affil=Department of Pathology, Kawasaki Medical School
kn-affil=
affil-num=5
en-affil=Department of Dermatology, Kawasaki Medical School
kn-affil=
affil-num=6
en-affil=Department of Breast and Thyroid Surgery, Kawasaki Medical School
kn-affil=
affil-num=7
en-affil=Department of Radiology, Kawasaki Medical School
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=hypofractionated radiotherapy
kn-keyword=hypofractionated radiotherapy
en-keyword=radiation-induced angiosarcoma
kn-keyword=radiation-induced angiosarcoma
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=口蓋の形成におけるメカニカルストレスの影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NAGATAMasayo
en-aut-sei=NAGATA
en-aut-mei=Masayo
kn-aut-name=永田倭代
kn-aut-sei=永田
kn-aut-mei=倭代
aut-affil-num=1
ORCID=
affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END
start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=163
end-page=170
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Impact of Light Touch and Pin Prick on Functional Outcomes in Patients with Traumatic Spinal Cord Injury
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A spinal cord injury (SCI) can cause severe lifelong functional disability and profoundly affect an individual’s daily life. We investigated the prediction of patients’ post-SCI functional outcomes by evaluating sensory scores rather than motor scores, as the latter’s association with functional outcomes is well established. We examined patients’ responses to a light touch (LT) and pin prick (PP) at admission and the response data’s usefulness as predictors of functional outcomes (i.e., ability to perform activities of daily living) at discharge. This exploratory observational study used data from the Japanese National Spinal Cord Injury Database (SCI-J). Data from 3,676 patients who met the inclusion criteria and were admitted for an SCI between 1997 and 2020 were analyzed. The motor score of the Functional Independence Measure (mFIM) at discharge was used as an index of functional outcome. A multiple regression analysis revealed that the mFIM was associated with both the LT response (β=0.07 (0.01), p<0.001) and the PP response (β=0.07 (0.01), p<0.001) at admission. The false discovery rate log-worth values for LT and PP were 6.6 and 8.5, respectively. Our findings demonstrate that LT and PP scores at admission can help predict patients’ functional outcomes after an SCI, although the magnitude of their contributions is not high.
en-copyright=
kn-copyright=
en-aut-name=DeguchiTakayuki
en-aut-sei=Deguchi
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KandaKanae
en-aut-sei=Kanda
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=FurusawaKazunari
en-aut-sei=Furusawa
en-aut-mei=Kazunari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=Nlandu Roger Ngatu
en-aut-sei=Nlandu Roger Ngatu
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=HiraoTomohiro
en-aut-sei=Hirao
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=Department of Rehabilitation, Kagawa Rosai Hospital
kn-affil=
affil-num=2
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=
affil-num=3
en-affil=Department of Rehabilitation Medicine, Kibikogen Rehabilitation Center for Employment Injuries
kn-affil=
affil-num=4
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=
affil-num=5
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=
en-keyword=functional independence measure
kn-keyword=functional independence measure
en-keyword=light touch
kn-keyword=light touch
en-keyword=pin prick
kn-keyword=pin prick
en-keyword=spinal cord injury
kn-keyword=spinal cord injury
en-keyword=Japanese National Spinal Cord Injury Database
kn-keyword=Japanese National Spinal Cord Injury Database
END
start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=151
end-page=161
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
en-copyright=
kn-copyright=
en-aut-name=KomatsubaraTadashi
en-aut-sei=Komatsubara
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TazawaHiroshi
en-aut-sei=Tazawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=HaseiJoe
en-aut-sei=Hasei
en-aut-mei=Joe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=OmoriToshinori
en-aut-sei=Omori
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SugiuKazuhisa
en-aut-sei=Sugiu
en-aut-mei=Kazuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MochizukiYusuke
en-aut-sei=Mochizuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=DemiyaKoji
en-aut-sei=Demiya
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=UrataYasuo
en-aut-sei=Urata
en-aut-mei=Yasuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=
affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=10
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=11
en-affil=Oncolys BioPharma, Inc.
kn-affil=
affil-num=12
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=13
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=14
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=soft-tissue sarcoma
kn-keyword=soft-tissue sarcoma
en-keyword=radiotherapy
kn-keyword=radiotherapy
en-keyword=oncolytic adenovirus
kn-keyword=oncolytic adenovirus
en-keyword=p53
kn-keyword=p53
en-keyword=BCL-xL
kn-keyword=BCL-xL
END
start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=95
end-page=106
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Roles of Neuropeptide Y in Respiratory Disease Pathogenesis via the Airway Immune Response
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
en-copyright=
kn-copyright=
en-aut-name=ItanoJunko
en-aut-sei=Itano
en-aut-mei=Junko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MiyaharaNobuaki
en-aut-sei=Miyahara
en-aut-mei=Nobuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
affil-num=1
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=
affil-num=3
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=4
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=
en-keyword=neuropeptide y
kn-keyword=neuropeptide y
en-keyword=Y1 receptor
kn-keyword=Y1 receptor
en-keyword=airway immune response
kn-keyword=airway immune response
en-keyword=bronchial epithelial cells
kn-keyword=bronchial epithelial cells
en-keyword=respiratory disease
kn-keyword=respiratory disease
END
start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=
article-no=
start-page=169
end-page=181
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Relationship between Social Networks and ISO15189 Accreditation
kn-title=社会ネットワークとISO15189認定取得との関連
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NAGATAHiroyo
en-aut-sei=NAGATA
en-aut-mei=Hiroyo
kn-aut-name=永田啓代
kn-aut-sei=永田
kn-aut-mei=啓代
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END
start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=6
article-no=
start-page=635
end-page=645
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202312
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Nutritional Support Combined with Neuromuscular Electrical Stimulation on Muscle Strength and Thickness: A Randomized Controlled Trial in Healthy Young Adult Males
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted.
en-copyright=
kn-copyright=
en-aut-name=IkedaTomohiro
en-aut-sei=Ikeda
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=OkamuraKazunori
en-aut-sei=Okamura
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=HasegawaMasaki
en-aut-sei=Hasegawa
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TanakaSatoshi
en-aut-sei=Tanaka
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KanaiShusaku
en-aut-sei=Kanai
en-aut-mei=Shusaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=Department of Rehabilitation Medicine, Okayama University Hospital
kn-affil=
affil-num=2
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=
affil-num=3
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=
affil-num=4
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=
affil-num=5
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=
en-keyword=whey protein
kn-keyword=whey protein
en-keyword=electrical stimulation
kn-keyword=electrical stimulation
en-keyword=muscle strength
kn-keyword=muscle strength
en-keyword=healthy volunteers
kn-keyword=healthy volunteers
END
start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=10
article-no=
start-page=1035
end-page=1045
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220913
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evidence on percutaneous radiofrequency and microwave ablation for liver metastases over the last decade
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose This review aimed to summarize the treatment outcomes of percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA) for metastatic liver tumors based on the findings of published studies over the last decade.
Materials and methods Literature describing the survival outcomes of ablation therapy for liver metastases was explored using the PubMed database on April 26, 2022, and articles published in 2012 or later were selected. The included studies met the following criteria: (i) English literature, (ii) original clinical studies, and (iii) literature describing overall survival (OS) of thermal ablation for metastatic liver tumors. All case reports and cohort studies with fewer than 20 patients and those that evaluated ablation for palliative purposes were excluded.
Results RFA was the most commonly used method for ablation, while MWA was used in several recent studies. RFA and MWA for liver metastases from various primary tumors have been reported; however, majority of the studies focused on colorectal cancer. The local control rate by RFA and MWA varied widely among the studies, ranging approximately 50–90%. Five-year survival rates of 20–60% have been reported following ablation for colorectal liver metastases by a number of studies, and several reports of 10-year survival rates were also noted.
Conclusion Comparative studies of local therapies for colorectal liver metastases demonstrated that RFA provides comparable survival outcomes to surgical metastasectomy and stereotactic body radiation therapy.
en-copyright=
kn-copyright=
en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KawabataTakahiro
en-aut-sei=Kawabata
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MunetomoKazuaki
en-aut-sei=Munetomo
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=NagataShoma
en-aut-sei=Nagata
en-aut-mei=Shoma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=2
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=4
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=5
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=6
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=7
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=8
en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Ablation
kn-keyword=Ablation
en-keyword=Liver
kn-keyword=Liver
en-keyword=Metastasis
kn-keyword=Metastasis
END
start-ver=1.4
cd-journal=joma
no-vol=155
cd-vols=
no-issue=
article-no=
start-page=105797
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202311
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ruxolitinib altered IFN-β induced necroptosis of human dental pulp stem cells during osteoblast differentiation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective: This study aimed to evaluate the role of ruxolitinib in the interferon beta (IFN-β) mediated osteoblast differentiation using human dental pulp stem cells (hDPSCs).
Design: hDPSCs from five deciduous teeth of healthy patients were stimulated by adding human recombinant IFN-β protein (1 or 2 ng/ml) to the osteogenic differentiation induction medium. Substrate formation was determined using Alizarin Red staining, calcium concentration, and osteoblast marker expression levels. Ruxolitinib was used to inhibit the Janus kinase/signal transducers and activators of transcription (JAK-STAT) pathway. Apoptosis was detected using terminal deoxynucleotidyl nick-end labeling (TUNEL) staining, and necroptosis was detected using propidium iodide staining and phosphorylated mixed lineage kinase domain-like protein (pMLKL) expression.
Results: In the IFN-β-treated group, substrate formation was inhibited by a reduction in alkaline phosphatase (ALP) expression in a concentration-dependent manner. Although the proliferation potency was unchanged between the IFN-β-treated and control groups, the cell number was significantly reduced in the experimental group. TUNEL-positive cell number was not significantly different; however, the protein level of necroptosis markers, interleukin-6 (IL-6) and pMLKL were significantly increased in the substrate formation. Cell number and ALP expression level were improved in the group administered ruxolitinib, a JAK-STAT inhibitor. Additionally, ruxolitinib significantly suppressed IL-6 and pMLKL levels.
Conclusion: Ruxolitinib interfered with the IFN-β-mediated necroptosis and osteogenic differentiation via the JAK-STAT pathway.
en-copyright=
kn-copyright=
en-aut-name=TanakaAtsuko
en-aut-sei=Tanaka
en-aut-mei=Atsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=HayanoSatoru
en-aut-sei=Hayano
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NagataMasayo
en-aut-sei=Nagata
en-aut-mei=Masayo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=KosamiTakahiro
en-aut-sei=Kosami
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=WangZiyi
en-aut-sei=Wang
en-aut-mei=Ziyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=
affil-num=2
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=
affil-num=3
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=5
en-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=6
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Type-I interferon
kn-keyword=Type-I interferon
en-keyword=Janus kinase/signal transducers and activators of transcription pathway
kn-keyword=Janus kinase/signal transducers and activators of transcription pathway
en-keyword=Osteoblast
kn-keyword=Osteoblast
en-keyword=Necroptosis
kn-keyword=Necroptosis
en-keyword=Singleton-Merten Syndrome
kn-keyword=Singleton-Merten Syndrome
END
start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=5
article-no=
start-page=545
end-page=552
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Endoscopic Manifestations and Clinical Characteristics of Localized Gastric Light-Chain Amyloidosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant.
en-copyright=
kn-copyright=
en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TanakaShouichi
en-aut-sei=Tanaka
en-aut-mei=Shouichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=ToyokawaTatsuya
en-aut-sei=Toyokawa
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NishimuraMamoru
en-aut-sei=Nishimura
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=TsuzukiTakao
en-aut-sei=Tsuzuki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MiyaharaKoji
en-aut-sei=Miyahara
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=NegishiShin
en-aut-sei=Negishi
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=OhyaShogen
en-aut-sei=Ohya
en-aut-mei=Shogen
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=OtsukaMotoyuki
en-aut-sei=Otsuka
en-aut-mei=Motoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Gastroenterology, National Hospital Organization Iwakuni Clinical Center
kn-affil=
affil-num=3
en-affil=Department of Gastroenterology, National Hospital Organization Fukuyama Medical Center
kn-affil=
affil-num=4
en-affil=Department of Internal Medicine, Okayama City Hospital
kn-affil=
affil-num=5
en-affil=Department of Internal Medicine, Japanese Red Cross Society Himeji Hospital
kn-affil=
affil-num=6
en-affil=Department of Internal Medicine, Hiroshima City Hiroshima Citizens Hospital
kn-affil=
affil-num=7
en-affil=Department of Gastroenterology, Kagawa Prefectural Central Hospital
kn-affil=
affil-num=8
en-affil=Kawaguchi Medical Clinic
kn-affil=
affil-num=9
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=esophagogastroduodenoscopy
kn-keyword=esophagogastroduodenoscopy
en-keyword=gastric lesion
kn-keyword=gastric lesion
en-keyword=amyloidosis
kn-keyword=amyloidosis
en-keyword=light chain
kn-keyword=light chain
END
start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=10
article-no=
start-page=1024
end-page=1034
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220702
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Up-to-date evidence on image-guided thermal ablation for metastatic lung tumors: a review
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this review was to summarize the latest evidence on image-guided thermal ablation therapies for lung metastases. PubMed was used to search for relevant articles that reported the oncological outcomes of thermal ablation for metastatic lung tumors, and those published in 2010 or later were selected for review. Ablative therapies were applied for lung metastases from various types of primary tumors, but most commonly colorectal ones. Radiofrequency ablation (RFA) was the most evaluated technique, followed by microwave ablation (MWA). The local control rates of ablative therapies were generally favorable, approximately 80–90% in many studies. Representative studies demonstrated promising overall survival rates of approximately 50% or higher 5 years after ablation for lung metastases from colorectal cancer or mixed types of primary tumors. Nevertheless, the survival outcomes varied depending on the type of primary tumor and background factors of patients such as other metastases and comorbidities. Several studies had aimed to compare the outcomes of various ablative therapies such as RFA, MWA, and cryoablation; however, conclusive data are not yet available to determine the most appropriate ablation modality for lung metastases. Further data accumulation is needed, especially for long-term outcomes and comparisons with other therapies.
en-copyright=
kn-copyright=
en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KawabataTakahiro
en-aut-sei=Kawabata
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MunetomoKazuaki
en-aut-sei=Munetomo
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=NagataShoma
en-aut-sei=Nagata
en-aut-mei=Shoma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=3
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=4
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=5
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=6
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=7
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=8
en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Ablation
kn-keyword=Ablation
en-keyword=Lung
kn-keyword=Lung
en-keyword=Pulmonary
kn-keyword=Pulmonary
en-keyword=Metastasis
kn-keyword=Metastasis
END
start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=6974
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230428
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A blue-shifted anion channelrhodopsin from the Colpodellida alga Vitrella brassicaformis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Microbial rhodopsins, a family of photoreceptive membrane proteins containing the chromophore retinal, show a variety of light-dependent molecular functions. Channelrhodopsins work as light-gated ion channels and are widely utilized for optogenetics, which is a method for controlling neural activities by light. Since two cation channelrhodopsins were identified from the chlorophyte alga Chlamydomonas reinhardtii, recent advances in genomic research have revealed a wide variety of channelrhodopsins including anion channelrhodopsins (ACRs), describing their highly diversified molecular properties (e.g., spectral sensitivity, kinetics and ion selectivity). Here, we report two channelrhodopsin-like rhodopsins from the Colpodellida alga Vitrella brassicaformis, which are phylogenetically distinct from the known channelrhodopsins. Spectroscopic and electrophysiological analyses indicated that these rhodopsins are green- and blue-sensitive pigments (lambda(max) = similar to 550 and similar to 440 nm) that exhibit light-dependent ion channeling activities. Detailed electrophysiological analysis revealed that one of them works as a monovalent anion (Cl-, Br- and NO3-) channel and we named it V. brassicaformis anion channelrhodopsin-2, VbACR2. Importantly, the absorption maximum of VbACR2 (similar to 440 nm) is blue-shifted among the known ACRs. Thus, we identified the new blue-shifted ACR, which leads to the expansion of the molecular diversity of ACRs.
en-copyright=
kn-copyright=
en-aut-name=KojimaKeiichi
en-aut-sei=Kojima
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KawanishiShiho
en-aut-sei=Kawanishi
en-aut-mei=Shiho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NishimuraYosuke
en-aut-sei=Nishimura
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=HasegawaMasumi
en-aut-sei=Hasegawa
en-aut-mei=Masumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NakaoShin
en-aut-sei=Nakao
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NagataYuya
en-aut-sei=Nagata
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=YoshizawaSusumu
en-aut-sei=Yoshizawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=SudoYuki
en-aut-sei=Sudo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Research Center for Bioscience and Nanoscience (CeBN), Research Institute for Marine Resources Utilization, Japan Agency for Marine-Earth Science and Technology (JAMSTEC)
kn-affil=
affil-num=4
en-affil=Institute for Extra‑Cutting‑Edge Science and Technology Avant‑Garde Research (X‑Star)
kn-affil=
affil-num=5
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=6
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=7
en-affil=Atmosphere and Ocean Research Institute, The University of Tokyo
kn-affil=
affil-num=8
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END
start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=3
article-no=
start-page=235
end-page=241
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Endocrinological Changes after Anamorelin Administration in Patients with Gastrointestinal Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Changes in hormone levels in patients with cancer cachexia after anamorelin administration have not been fully investigated. This study aimed to determine how anamorelin affects the endocrine system in patients with gastrointestinal cancer and cachexia. We prospectively enrolled 13 patients and comprehensively investigated their body weight and levels of serum albumin, hemoglobin A1c (HbA1c), and hormones before (week 0) and 3 and 12 weeks after anamorelin administration. The variables were evaluated at week 3 in 9 patients and at week 12 in 5 patients. At week 3, anamorelin administration resulted in body weight gain and increased the levels of growth hormone and HbA1c, as well as insulin-like growth factor-1 standard deviation scores (IGF-1 SD scores). At the same time, negative correlations were observed between ΔIGF-1 SD score and Δthyroidstimulating hormone (TSH) and between ΔIGF-1 SD score and Δfree testosterone. ΔBody weight and ΔIGF-1 SD score correlated positively at week 12. These results suggest that TSH and free testosterone levels can be affected 3 weeks after anamorelin administration; however, those variables tend to return to a state of equilibrium, and anabolic effects of anamorelin appear in long-term (≥ 12 weeks) users.
en-copyright=
kn-copyright=
en-aut-name=KuraokaSakiko
en-aut-sei=Kuraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SatomiTakuya
en-aut-sei=Satomi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YamazakiTatsuhiro
en-aut-sei=Yamazaki
en-aut-mei=Tatsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=HamadaKenta
en-aut-sei=Hamada
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KonoYoshiyasu
en-aut-sei=Kono
en-aut-mei=Yoshiyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KanzakiHiromitsu
en-aut-sei=Kanzaki
en-aut-mei=Hiromitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=9
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=anamorelin
kn-keyword=anamorelin
en-keyword=body weight
kn-keyword=body weight
en-keyword=cancer cachexia
kn-keyword=cancer cachexia
en-keyword=endocrine system
kn-keyword=endocrine system
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=下顎枝垂直骨切り術に伴う下顎頭の位置変化および変位に関連する要因の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NAGATAYuki
en-aut-sei=NAGATA
en-aut-mei=Yuki
kn-aut-name=永田裕樹
kn-aut-sei=永田
kn-aut-mei=裕樹
aut-affil-num=1
ORCID=
affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=歯周感染・炎症が妊娠や子宮組織に及ぼす影響の免疫学的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NAGATAChiaki
en-aut-sei=NAGATA
en-aut-mei=Chiaki
kn-aut-name=永田千晶
kn-aut-sei=永田
kn-aut-mei=千晶
aut-affil-num=1
ORCID=
affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END
start-ver=1.4
cd-journal=joma
no-vol=18
cd-vols=
no-issue=2
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230224
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Diarrhea and related personal characteristics among Japanese university students studying abroad in intermediate- and low-risk countries
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Despite an increasing number of students studying abroad worldwide, evidence about health risks while they are abroad is limited. Diarrhea is considered the most common travelers' illness, which would also apply to students studying abroad. We examined diarrhea and related personal characteristics among Japanese students studying abroad. Japanese university students who participated in short-term study abroad programs between summer 2016 and spring 2018 were targeted (n = 825, 6-38 travel days). Based on a 2-week-risk of diarrhea (passing three or more loose or liquid stools per day) among travelers by country, the destination was separated into intermediate- and low-risk countries. After this stratification, the associations between personal characteristics and diarrhea during the first two weeks of their stay were evaluated using logistic regression models. Among participants in intermediate-risk countries, teenagers, males and those with overseas travel experience were associated with an elevated risk of diarrhea; the odds ratios (95% confidence intervals) were 2.42 (1.08-5.43) for teenagers (vs. twenties), 1.93 (1.08-3.45) for males (vs. females) and 2.37 (1.29-4.33) for those with overseas experience (vs. none). Even restricting an outcome to diarrhea during the first week did not change the results substantially. The same tendency was not observed for those in the low-risk countries. Teenage students, males and those with overseas travel experience should be cautious about diarrhea while studying abroad, specifically in intermediate-risk countries.
en-copyright=
kn-copyright=
en-aut-name=YamakawaMichiyo
en-aut-sei=Yamakawa
en-aut-mei=Michiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TsudaToshihide
en-aut-sei=Tsuda
en-aut-mei=Toshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=WadaKeiko
en-aut-sei=Wada
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NagataChisato
en-aut-sei=Nagata
en-aut-mei=Chisato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SuzukiEtsuji
en-aut-sei=Suzuki
en-aut-mei=Etsuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
affil-num=1
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=2
en-affil=Department of Human Ecology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=
affil-num=3
en-affil=Department of Epidemiology and Preventive Medicine, Graduate School of Medicine, Gifu University
kn-affil=
affil-num=4
en-affil=Department of Epidemiology and Preventive Medicine, Graduate School of Medicine, Gifu University
kn-affil=
affil-num=5
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Renal cryoablation combined with prior transcatheter arterial embolization in non-dialysis patients with stage 4 or 5 chronic kidney disease: a retrospective study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose To retrospectively evaluate cryoablation combined with prior transcatheter arterial embolization (TAE) for renal cell carcinoma (RCC) in non-dialysis patients with stage 4 or 5 chronic kidney disease (CKD).
Materials and methods Patients with stage 4 or 5 CKD undergoing TAE and cryoablation for RCC between May 2012 and October 2021 were included. TAE was selectively performed using iodized oil with absolute ethanol or gelatin sponge 1–14 days before cryoablation. Local efficacy, safety, and changes in renal function were evaluated.
Results Nine patients (seven men and two women; median age, 64 years; range 52–88 years) with nine RCCs (mean diameter, 3.0 ± 1.0 cm; range 1.7–4.7 cm) were included. The mean pre-treatment estimated glomerular filtration rate (eGFR) was 24.2 ± 5.6 ml/min/1.73 m2 (range 10.4–29.2 ml/min/1.73 m2). The mean amount of contrast medium used in TAE was 58 ± 29 ml (range 40–128 ml). Except in one patient (grade 3 pyelonephritis), no grade ≥ 3 complications occurred. During the follow-up period (median, 18 months; range 7–54 months), no local tumor progression occurred. In two patients with pre-treatment eGFR of < 20 ml/min/1.73 m2, hemodialysis was initiated at 3 and 19 months after cryoablation. At their last follow-up, the remaining seven patients showed a decrease of 6.2 ± 5.3 ml/min/1.73 m2 (range 0.7–17.2 ml/min/1.73 m2) in their eGFR.
Conclusion Cryoablation combined with TAE for RCC in non-dialysis patients with stage 4 or 5 CKD was effective and safe, with an acceptable impact on renal function.
en-copyright=
kn-copyright=
en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KawabataTakahiro
en-aut-sei=Kawabata
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MunetomoKazuaki
en-aut-sei=Munetomo
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=NagataShoma
en-aut-sei=Nagata
en-aut-mei=Shoma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=GobaraHideo
en-aut-sei=Gobara
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=ArakiMotoo
en-aut-sei=Araki
en-aut-mei=Motoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
affil-num=1
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=2
en-affil=Deptartment of Radiological Technology, Okayama University Graduate School of Health Science
kn-affil=
affil-num=3
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=5
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=6
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=7
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=8
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=9
en-affil=Division of Medical Informatics, Okayama University Hospital
kn-affil=
affil-num=10
en-affil=Department of Urology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=11
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Renal cryoablation
kn-keyword=Renal cryoablation
en-keyword=Transcatheter arterial embolization
kn-keyword=Transcatheter arterial embolization
en-keyword=Chronic kidney disease
kn-keyword=Chronic kidney disease
END
start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=3
article-no=
start-page=314
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230303
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Fungal Metabolite (+)-Terrein Abrogates Inflammatory Bone Resorption via the Suppression of TNF-α Production in a Ligature-Induced Periodontitis Mouse Model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Current periodontal treatment focuses on the mechanical removal of the source of infection, such as bacteria and their products, and there is no approach to control the host inflammatory response that leads to tissue destruction. In order to control periodontal inflammation, we have previously reported the optimization of (+)-terrein synthesis methods and the inhibitory effect of (+)-terrein on osteoclast differentiation in vitro. However, the pharmacological effect of (+)-terrein in vivo in the periodontitis model is still unknown. In this study, we investigated the effect of synthetic (+)-terrein on inflammatory bone resorption using a ligature-induced periodontitis mouse model. Synthetic (+)-terrein (30 mg/kg) was administered intraperitoneally twice a week to the mouse periodontitis model. The control group was treated with phosphate buffer. One to two weeks after the induction of periodontitis, the periodontal tissues were harvested for radiological evaluation (micro-CT), histological evaluation (HE staining and TRAP staining), and the evaluation of inflammatory cytokine production in the periodontal tissues and serum (quantitative reverse-transcription PCR, ELISA). The synthetic (+)-terrein-treated group suppressed alveolar bone resorption and the number of osteoclasts in the periodontal tissues compared to the control group (p < 0.05). In addition, synthetic (+)-terrein significantly suppressed both mRNA expression of TNF-α in the periodontal tissues and the serum concentration of TNF-α (both p < 0.05). In conclusion, we have demonstrated that synthetic (+)-terrein abrogates alveolar bone resorption via the suppression of TNF-α production and osteoclast differentiation in vivo. Therefore, we could expect potential clinical effects when using (+)-terrein on inflammatory bone resorption, including periodontitis.
en-copyright=
kn-copyright=
en-aut-name=SakoHidefumi
en-aut-sei=Sako
en-aut-mei=Hidefumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=OmoriKazuhiro
en-aut-sei=Omori
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NakayamaMasaaki
en-aut-sei=Nakayama
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MandaiHiroki
en-aut-sei=Mandai
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=IdeguchiHidetaka
en-aut-sei=Ideguchi
en-aut-mei=Hidetaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=Yoshimura-NakagawaSaki
en-aut-sei=Yoshimura-Nakagawa
en-aut-mei=Saki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=SakaidaKyosuke
en-aut-sei=Sakaida
en-aut-mei=Kyosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=Nagata-KameiChiaki
en-aut-sei=Nagata-Kamei
en-aut-mei=Chiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=KobayashiHiroya
en-aut-sei=Kobayashi
en-aut-mei=Hiroya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=IshiiSatoki
en-aut-sei=Ishii
en-aut-mei=Satoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=OnoMitsuaki
en-aut-sei=Ono
en-aut-mei=Mitsuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=YamamotoTadashi
en-aut-sei=Yamamoto
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
en-aut-name=SugaSeiji
en-aut-sei=Suga
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=
en-aut-name=TakashibaShogo
en-aut-sei=Takashiba
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=
affil-num=1
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=
affil-num=2
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Department of Oral Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=4
en-affil=Department of Pharmacy, Faculty of Pharmacy, Gifu University of Medical Science
kn-affil=
affil-num=5
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=6
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=
affil-num=7
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=
affil-num=8
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=9
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=10
en-affil=Division of Applied Chemistry, Graduate School of Natural Sciences and Technology, Okayama University
kn-affil=
affil-num=11
en-affil=Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=12
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=13
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=14
en-affil=Division of Applied Chemistry, Graduate School of Natural Sciences and Technology, Okayama University
kn-affil=
affil-num=15
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=synthetic (+)-terrein
kn-keyword=synthetic (+)-terrein
en-keyword=periodontitis
kn-keyword=periodontitis
en-keyword= TNF-α
kn-keyword= TNF-α
END
start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=2
article-no=
start-page=121
end-page=129
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Complications of Percutaneous Cryoablation for Renal Tumors and Methods for Avoiding Them
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Percutaneous cryoablation of renal tumors is widely used because of its high efficacy and safety. This high safety can be attributed, at least in part, to the visibility of the ablated area as an “ice ball”. This therapy has fewer complications (incidence, 0-7.2%) and is less invasive than surgery. Minor bleeding is inevitable in most kidney-related procedures, and indeed the most common complication of this therapy is bleeding (hematoma and hematuria). However, patients require treatment such as transfusion or transarterial embolization in only 0-4% of bleeding cases. Various other complications such as ureteral or collecting system injury, bowel injury, nerve injury, skin injury, infection, pneumothorax, and tract seeding also occur, but they are usually minor and asymptomatic. However, operators should know and avoid the various complications associated with this therapy. This study aimed to summarize the complications of percutaneous cryoablation for renal tumors and provide some techniques for achieving safe procedures.
en-copyright=
kn-copyright=
en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KawabataTakahiro
en-aut-sei=Kawabata
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MunetomoKazuaki
en-aut-sei=Munetomo
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=NagataShoma
en-aut-sei=Nagata
en-aut-mei=Shoma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=ArakiMotoo
en-aut-sei=Araki
en-aut-mei=Motoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=2
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=3
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=4
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=5
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=6
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=7
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=8
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
affil-num=9
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
affil-num=10
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
en-keyword=cryosurgery
kn-keyword=cryosurgery
en-keyword=kidney neoplasms
kn-keyword=kidney neoplasms
en-keyword=carcinoma
kn-keyword=carcinoma
en-keyword=renal cell
kn-keyword=renal cell
en-keyword=complication
kn-keyword=complication
END
start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=1
article-no=
start-page=105
end-page=109
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202302
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Initial Two Doses of COVID-19 Vaccine mRNA-1273 for an Individual Previously Vaccinated with Two Doses of an Inactivated Vaccine CoronaVac That Has Not Been Approved in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The inactivated coronavirus disease 2019 vaccine CoronaVac has not been approved in Japan. Little information is available on cases in Japan in which an approved mRNA vaccine was administered as the initial (first or second) dose after two doses of CoronaVac. Furthermore, the safety and efficacy of this combination are not established. We here evaluated the safety and efficacy in a patient who showed an antibody response to an approved vaccine, mRNA-1273, after a previous vaccination with CoronaVac. The adverse events consisted of only mild local and systemic common reactions and were transient. In addition, a strong and persistent antibody response was observed.
en-copyright=
kn-copyright=
en-aut-name=IwasakiYoshiaki
en-aut-sei=Iwasaki
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=HiguchiChigusa
en-aut-sei=Higuchi
en-aut-mei=Chigusa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
affil-num=1
en-affil=Health Service Center, Okayama University
kn-affil=
affil-num=2
en-affil=Health Service Center, Okayama University
kn-affil=
en-keyword=coronavirus disease 2019
kn-keyword=coronavirus disease 2019
en-keyword=severe acute respiratory syndrome coronavirus 2
kn-keyword=severe acute respiratory syndrome coronavirus 2
en-keyword=vaccine
kn-keyword=vaccine
en-keyword=adverse events
kn-keyword=adverse events
en-keyword=antibody response
kn-keyword=antibody response
END
start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=6
article-no=
start-page=743
end-page=748
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Posterolateral Floating Technique for the Thoracic Ossification of the Posterior Longitudinal Ligament with Navigation: A Technical Note
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We describe a floating technique via a posterolateral approach with intraoperative O-arm navigation to facilitate decompression of the spinal cord in thoracic myelopathy due to severe ossification of the posterior longitudinal ligament (OPLL). A 62-year-old man with myelopathy due to thoracic OPLL had left-leg muscle weakness, urinary disturbance, and spastic gait. Bilateral leg pain and gait disturbance had persisted for 2 years. He was successfully treated by the posterolateral OPLL floating procedure and posterior pedicle fixation under O-arm navigation. At a 2-year follow-up, manual muscle testing results and sensory function of the left leg had recovered fully. His cervical Japanese Orthopedic Association score had improved from 5/12 to 11/12. The novel intraoperative O-arm navigation-guided posterolateral floating procedure for thoracic OPLL is effective for achieving precise decompression and strong fixation with a posterior approach only and can provide an excellent result for severe thoracic OPLL without the risk of adverse events from intraoperative radiation.
en-copyright=
kn-copyright=
en-aut-name=TanakaMasato
en-aut-sei=Tanaka
en-aut-mei=Masato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SutharHardik
en-aut-sei=Suthar
en-aut-mei=Hardik
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=DesaiDhvanit
en-aut-sei=Desai
en-aut-mei=Dhvanit
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YamauchiTaro
en-aut-sei=Yamauchi
en-aut-mei=Taro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=AratakiShinya
en-aut-sei=Arataki
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=FujiwaraYoshihiro
en-aut-sei=Fujiwara
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=UotaniKoji
en-aut-sei=Uotani
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=OdaYoshiaki
en-aut-sei=Oda
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=MisawaHaruo
en-aut-sei=Misawa
en-aut-mei=Haruo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=
affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=
affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=
affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=
affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=
affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=
affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=
affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=
affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=
en-keyword=ossification of the posterior longitudinal ligament
kn-keyword=ossification of the posterior longitudinal ligament
en-keyword=floating method
kn-keyword=floating method
en-keyword= navigation surgery
kn-keyword= navigation surgery
en-keyword=C-arm free
kn-keyword=C-arm free
END
start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=6
article-no=
start-page=705
end-page=713
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Impact of Tofogliflozin on Physiological and Hormonal Function, Serum Electrolytes, and Cardiac Diastolic Function in Elderly Japanese Patients with Type 2 Diabetes Mellitus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function.
en-copyright=
kn-copyright=
en-aut-name=HigashikawaToshihiro
en-aut-sei=Higashikawa
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ItoTomohiko
en-aut-sei=Ito
en-aut-mei=Tomohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MizunoTakurou
en-aut-sei=Mizuno
en-aut-mei=Takurou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=IshigamiKeiichiro
en-aut-sei=Ishigami
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KurokiKengo
en-aut-sei=Kuroki
en-aut-mei=Kengo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MaekawaNaoto
en-aut-sei=Maekawa
en-aut-mei=Naoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=UsudaDaisuke
en-aut-sei=Usuda
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=IzumidaToshihide
en-aut-sei=Izumida
en-aut-mei=Toshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=YamadaShinya
en-aut-sei=Yamada
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=SangenRyusho
en-aut-sei=Sangen
en-aut-mei=Ryusho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=HamadaKazu
en-aut-sei=Hamada
en-aut-mei=Kazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=KiyosawaJun
en-aut-sei=Kiyosawa
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=SaitoAtsushi
en-aut-sei=Saito
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
en-aut-name=IguchiMasaharu
en-aut-sei=Iguchi
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=
en-aut-name=KasamakiYuji
en-aut-sei=Kasamaki
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=
en-aut-name=NakahashiTakeshi
en-aut-sei=Nakahashi
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=
en-aut-name=FukudaAkihiro
en-aut-sei=Fukuda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=
en-aut-name=SaitoHitoshi
en-aut-sei=Saito
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=
en-aut-name=KandaTsugiyasu
en-aut-sei=Kanda
en-aut-mei=Tsugiyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=
en-aut-name=OkuroMasashi
en-aut-sei=Okuro
en-aut-mei=Masashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=
affil-num=1
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=2
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=3
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=4
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=5
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=6
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=7
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=8
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=9
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=10
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=11
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=12
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=13
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=14
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=15
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=16
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=17
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=18
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=19
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=
affil-num=20
en-affil=Department of Geriatric Medicine, Kanazawa Medical University
kn-affil=
en-keyword=tofogliflozin
kn-keyword=tofogliflozin
en-keyword=SGLT2 inhibitor
kn-keyword=SGLT2 inhibitor
en-keyword=elderly patient
kn-keyword=elderly patient
en-keyword=HbA1c
kn-keyword=HbA1c
en-keyword=cardiac diastolic function
kn-keyword=cardiac diastolic function
END
start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=3
article-no=
start-page=323
end-page=328
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Case of a Solitary Cortical Tuber with No Other Manifestations of Tuberous Sclerosis Complex Mimicking Focal Cortical Dysplasia Type II with Calcification
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cortical tubers are one of the typical intracranial manifestations of tuberous sclerosis complex (TSC). Multiple cortical tubers are easy to diagnose as TSC; however, a solitary cortical tuber without any other cutaneous or visceral organ manifestations can be confused with other conditions, particularly focal cortical dysplasia. We report a surgical case of refractory epilepsy caused by a solitary cortical tuber mimicking focal cortical dysplasia type II, and describe the radiological, electrophysiological, and histopathological findings of our case.
en-copyright=
kn-copyright=
en-aut-name=HosomotoKakeru
en-aut-sei=Hosomoto
en-aut-mei=Kakeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SasakiTatsuya
en-aut-sei=Sasaki
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KawaiKoji
en-aut-sei=Kawai
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=OkazakiYosuke
en-aut-sei=Okazaki
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=HyodoYuki
en-aut-sei=Hyodo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=ShibataTakashi
en-aut-sei=Shibata
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=SasadaSusumu
en-aut-sei=Sasada
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=YasuharaTakao
en-aut-sei=Yasuhara
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=KobayashiKatsuhiro
en-aut-sei=Kobayashi
en-aut-mei=Katsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=YanaiHiroyuki
en-aut-sei=Yanai
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=5
en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=6
en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=7
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=8
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=9
en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=10
en-affil=Department of Diagnostic Pathology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=11
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=cortical tuber
kn-keyword=cortical tuber
en-keyword=epilepsy
kn-keyword=epilepsy
en-keyword=focal cortical dysplasia
kn-keyword=focal cortical dysplasia
en-keyword=transmantle sign
kn-keyword=transmantle sign
en-keyword=tuberous sclerosis complex
kn-keyword=tuberous sclerosis complex
END
start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=3
article-no=
start-page=141
end-page=145
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=199906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Medical students’ perception of inpatients’ anxiety, self-esteem, purpose-in-life and health locus of control as compared with nursing practitioners’
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Medical students (fourth-year: n = 67; fifth-year: n = 63) estimated inpatients' feelings of anxiety, self-esteem, purpose-in-life, and multidimensional health locus of control. Their ratings were compared both with the ratings given by the 121 inpatients themselves and with those given by nursing practitioners (nurses and nursing students). Findings showed that the medical students overestimated inpatients' anxiety, while they underestimated the inpatients' purpose-in-life and internal health locus of control. Hence they underestimated, as did the nursing practitioners, the inpatients' positive emotional states and their positive attitude toward their own lives. Fifth-year medical students, with clinical experience, rated the inpatients' score of chance health locus of control higher than did the fourth-year medical students, who had no clinical experience. These findings indicate that medical students, like nursing practitioners, are inclined to pay more attention to inpatients' weaknesses than to their strengths.
en-copyright=
kn-copyright=
en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=OhtaTakeo
en-aut-sei=Ohta
en-aut-mei=Takeo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=AoyamaHideyasu
en-aut-sei=Aoyama
en-aut-mei=Hideyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
affil-num=1
en-affil=Faculty of Economics, Okayama University
kn-affil=
affil-num=2
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=
affil-num=3
en-affil=Department of Hygiene and Preventive Medicine, Okayama University Medical School
kn-affil=
en-keyword=inpatient's mental health
kn-keyword=inpatient's mental health
en-keyword=anxiety
kn-keyword=anxiety
en-keyword=self-esteem
kn-keyword=self-esteem
en-keyword=purpose-in-life
kn-keyword=purpose-in-life
en-keyword=health locus of control
kn-keyword=health locus of control
END
start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=5
article-no=
start-page=625
end-page=629
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histologic Transformation from Follicular Lymphoma to Diffuse Large B-cell Lymphoma Detected during Colonoscopy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 77-year-old Japanese woman who had been treated for follicular lymphoma for 8 years developed abdominal pain and intra-abdominal lymphadenopathies. Colonoscopy revealed an elevated lesion in the rectum, which presented as two humps with erosions. A diagnosis of histologic transformation of follicular lymphoma to diffuse large B-cell lymphoma was made by endoscopic biopsy. This case underscores the importance of endoscopy examinations and biopsy of newly emerged gastrointestinal lesions for the prompt diagnosis of histologic transformation, since salvage chemotherapy must be initiated quickly in such cases.
en-copyright=
kn-copyright=
en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=YamasakiYasushi
en-aut-sei=Yamasaki
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=AsadaNoboru
en-aut-sei=Asada
en-aut-mei=Noboru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=MatsuokaKen-ichi
en-aut-sei=Matsuoka
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=HiraokaSakiko
en-aut-sei=Hiraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KawaharaYoshiro
en-aut-sei=Kawahara
en-aut-mei=Yoshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=4
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=5
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=7
en-affil=Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital
kn-affil=
affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=colorectal lymphoma
kn-keyword=colorectal lymphoma
en-keyword=follicular lymphoma
kn-keyword=follicular lymphoma
en-keyword=diffuse large B-cell lymphoma
kn-keyword=diffuse large B-cell lymphoma
en-keyword=histologic transformation
kn-keyword=histologic transformation
END
start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=4
article-no=
start-page=403
end-page=413
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Surgical Treatment of Epiretinal Membrane
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Epiretinal membrane (ERM) is a common retinal disease characterized by cellular proliferation and metaplasia that lead to the formation of a pathological fibrocellular membrane immediately superjacent to the inner retinal surface. The vast majority of ERMs are considered idiopathic. However, ERM formation can result from various primary intraocular diseases, including retinal breaks and detachment, retinal vascular diseases, and vitreoretinal inflammatory conditions. Although ERMs are generally asymptomatic or cause mild metamorphopsia and/or a modest decrease in visual acuity, some can cause severe macular distortion and macular edema, resulting in significantly impaired function. Surgical removal of ERM is the only treatment, and improvements in vitrectomy systems have enabled less invasive treatment. However, there are currently no standardized criteria for ERM surgery, and the indications for surgery are determined from the patient’s subjective symptoms. Another problem with ERM surgery is that not all patients show satisfactory postoperative recovery of visual function. Thus, further research is needed to determine the criteria for ERM surgery and methods to improve the postoperative prognosis.
en-copyright=
kn-copyright=
en-aut-name=MatobaRyo
en-aut-sei=Matoba
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
affil-num=1
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=epiretinal membrane
kn-keyword=epiretinal membrane
en-keyword=vitrectomy
kn-keyword=vitrectomy
en-keyword=optical coherence tomography
kn-keyword=optical coherence tomography
en-keyword=internal limiting membrane
kn-keyword=internal limiting membrane
en-keyword=lamellar macular hole
kn-keyword=lamellar macular hole
END
start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=3
article-no=
start-page=345
end-page=349
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Predictors of Hypotension after Adrenalectomy for Pheochromocytoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The management of blood pressure is a significant concern for surgeons and anesthesiologists performing adrenalectomy for pheochromocytoma. We evaluated clinical factors in pheochromocytoma patients to identify the predictors of postoperative hypotension. The medical records of patients who underwent adrenalectomy for pheochromocytoma between 2001 and 2017 were retrospectively reviewed and clinical and biochemical data were evaluated. Of 29 patients, 13 patients needed catecholamine support in the perisurgical period while 16 patients did not. There were significant differences in median age, tumor size, and blood pressure drop (maxmin) between the 2 groups (68 vs 53 years old, p=0.045; 50 vs 32 mm diameter, p=0.022; 110 vs 71 mmHg, p=0.015 respectively). In univariate logistic analysis, age > 65.5 years, tumor size > 34.5 mm, urine metanephrine > 0.205 mg/day and urine normetanephrine > 0.665 mg/day were significant predictors of prolonged hypotension requiring postoperative catecholamine support. Tumor size and urine metanephrine and urine normetanephrine levels were correlated with postoperative hypotension. These predictors may help in the safe perioperative management of pheochromocytoma patients treated with adrenalectomy.
en-copyright=
kn-copyright=
en-aut-name=KoyamaKanae
en-aut-sei=Koyama
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MiuraNoriyoshi
en-aut-sei=Miura
en-aut-mei=Noriyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=WatanabeRyuta
en-aut-sei=Watanabe
en-aut-mei=Ryuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=SawadaYuichiro
en-aut-sei=Sawada
en-aut-mei=Yuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NodaTerutaka
en-aut-sei=Noda
en-aut-mei=Terutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NishimuraKenichi
en-aut-sei=Nishimura
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=AsaiSeiji
en-aut-sei=Asai
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=FukumotoTetsuya
en-aut-sei=Fukumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=YanagiharaYutaka
en-aut-sei=Yanagihara
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=MiyauchiYuki
en-aut-sei=Miyauchi
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=KikugawaTadahiko
en-aut-sei=Kikugawa
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=SaikaTakashi
en-aut-sei=Saika
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
affil-num=1
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=2
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=3
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=4
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=5
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=6
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=7
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=8
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=9
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=10
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=11
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
affil-num=12
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
en-keyword=urinary metanephrine
kn-keyword=urinary metanephrine
en-keyword= urinary normetanephrine
kn-keyword= urinary normetanephrine
en-keyword=adrenalectomy
kn-keyword=adrenalectomy
en-keyword=pheochromocytoma
kn-keyword=pheochromocytoma
END
start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=2
article-no=
start-page=115
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Awareness of Complications of Dental Treatment in Patients Treated with Drugs Affecting the Immune System : A Nationwide Questionnaire Survey of Dental Practitioners in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study was to investigate the awareness and experience, among dental practitioners, of adverse events resulting from dental treatment of patients undergoing therapy with drugs that affect the immune system [angiogenesis inhibitors, biological agents, immunosuppressants, and disease-modifying anti-rheumatic drugs (DMARDs)]. For this purpose, a nationwide questionnaire survey was conducted. Questionnaires were sent to 2,050 dentists, of which 206 (10.1%) were completed and returned. The results showed that most dentists were aware of complications associated with dental treatment of patients treated with drugs that affect the immune system, and about half had actually experienced such complications. Delayed wound healing, osteonecrosis of the jaw (ONJ), and postoperative infections were reported. Whereas approximately 50% of dentists did not discontinue the drugs during dental treatment, about 18% did. During temporary drug discontinuation, some patients experienced aggravation of the primary disease, such as worsening of rheumatism, growth of tumors, and rejection reactions of transplanted organs. As for medical cooperation, only less than half of the dentists were asked for oral hygiene management by a physician prior to starting the drug treatment. Prospective studies are needed because evidence for dental treatments in patients treated with these drugs remains limited.
en-copyright=
kn-copyright=
en-aut-name=HitomiNishizaki
en-aut-sei=Hitomi
en-aut-mei=Nishizaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=YoshinariMorimoto
en-aut-sei=Yoshinari
en-aut-mei=Morimoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YamadaShin-ichi
en-aut-sei=Yamada
en-aut-mei=Shin-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=KuritaHiroshi
en-aut-sei=Kurita
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=TanakaAkira
en-aut-sei=Tanaka
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=YamaguchiAkira
en-aut-sei=Yamaguchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MiyataMasaru
en-aut-sei=Miyata
en-aut-mei=Masaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=YoshikawaHiromasa
en-aut-sei=Yoshikawa
en-aut-mei=Hiromasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=YanamotoSouichi
en-aut-sei=Yanamoto
en-aut-mei=Souichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=ImaiYutaka
en-aut-sei=Imai
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=Department of Critical Care Medicine and Dentistry, Graduate School of Dentistry, Kanagawa Dental University
kn-affil=
affil-num=2
en-affil=Department of Critical Care Medicine and Dentistry, Graduate School of Dentistry, Kanagawa Dental University
kn-affil=
affil-num=3
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=
affil-num=4
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=
affil-num=5
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=
affil-num=6
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=
affil-num=7
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=
affil-num=8
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=
affil-num=9
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=
affil-num=10
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=
en-keyword=angiogenesis inhibitor
kn-keyword=angiogenesis inhibitor
en-keyword=biological agent
kn-keyword=biological agent
en-keyword=disease-modifying antirheumatic drug (DMARD)
kn-keyword=disease-modifying antirheumatic drug (DMARD)
en-keyword=immunosuppressant
kn-keyword=immunosuppressant
en-keyword=medication-related osteonecrosis of the jaw (MRONJ)
kn-keyword=medication-related osteonecrosis of the jaw (MRONJ)
END
start-ver=1.4
cd-journal=joma
no-vol=22
cd-vols=
no-issue=3
article-no=
start-page=1024
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210120
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genetic Elucidation for Response of Flowering Time to Ambient Temperatures in Asian Rice Cultivars
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Climate resilience of crops is critical for global food security. Understanding the genetic basis of plant responses to ambient environmental changes is key to developing resilient crops. To detect genetic factors that set flowering time according to seasonal temperature conditions, we evaluated differences of flowering time over years by using chromosome segment substitution lines (CSSLs) derived from japonica rice cultivars "Koshihikari" x "Khao Nam Jen", each with different robustness of flowering time to environmental fluctuations. The difference of flowering times in 9 years' field tests was large in "Khao Nam Jen" (36.7 days) but small in "Koshihikari" (9.9 days). Part of this difference was explained by two QTLs. A CSSL with a "Khao Nam Jen" segment on chromosome 11 showed 28.0 days' difference; this QTL would encode a novel flowering-time gene. Another CSSL with a segment from "Khao Nam Jen" in the region around Hd16 on chromosome 3 showed 23.4 days" difference. A near-isogenic line (NIL) for Hd16 showed 21.6 days' difference, suggesting Hd16 as a candidate for this QTL. RNA-seq analysis showed differential expression of several flowering-time genes between early and late flowering seasons. Low-temperature treatment at panicle initiation stage significantly delayed flowering in the CSSL and NIL compared with "Koshihikari". Our results unravel the molecular control of flowering time under ambient temperature fluctuations.
en-copyright=
kn-copyright=
en-aut-name=HoriKiyosumi
en-aut-sei=Hori
en-aut-mei=Kiyosumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SaishoDaisuke
en-aut-sei=Saisho
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NagataKazufumi
en-aut-sei=Nagata
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NonoueYasunori
en-aut-sei=Nonoue
en-aut-mei=Yasunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=Uehara-YamaguchiYukiko
en-aut-sei=Uehara-Yamaguchi
en-aut-mei=Yukiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KanataniAsaka
en-aut-sei=Kanatani
en-aut-mei=Asaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=ShuKoka
en-aut-sei=Shu
en-aut-mei=Koka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=HirayamaTakashi
en-aut-sei=Hirayama
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=YonemaruJun-Ichi
en-aut-sei=Yonemaru
en-aut-mei=Jun-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=FukuokaShuichi
en-aut-sei=Fukuoka
en-aut-mei=Shuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=MochidaKeiichi
en-aut-sei=Mochida
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
affil-num=1
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=
affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
affil-num=3
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=
affil-num=4
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=
affil-num=5
en-affil=RIKEN Center for Sustainable Resource Science
kn-affil=
affil-num=6
en-affil=RIKEN Center for Sustainable Resource Science
kn-affil=
affil-num=7
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=
affil-num=8
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
affil-num=9
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=
affil-num=10
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=
affil-num=11
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=rice
kn-keyword=rice
en-keyword=flowering time
kn-keyword=flowering time
en-keyword=ambient temperature fluctuation
kn-keyword=ambient temperature fluctuation
en-keyword=chromosome segment substitution line (CSSL)
kn-keyword=chromosome segment substitution line (CSSL)
en-keyword=quantitative trait locus (QTL)
kn-keyword=quantitative trait locus (QTL)
END
start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=5
article-no=
start-page=455
end-page=459
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202010
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Study Protocol for Assessing the Efficacy of Compression Therapy Using Stockings and Sleeves to Prevent Docetaxel-Induced Peripheral Neuropathy in Breast Cancer Patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Taxanes are key drugs for patients with breast cancer. A major adverse effect associated with the administration of the taxane docetaxel is chemotherapy-induced peripheral neuropathy (CIPN). We are conducting a singlecenter, single-arm, open-label historical control trial to evaluate the ability of compression therapy using stockings or sleeves to prevent CIPN due to docetaxel treatment. The primary endpoint is the incidence of all-grade CIPN according to patients’ records until 3 weeks after the fourth docetaxel administration. This study’s results will clarify whether compression therapy using stockings or sleeves can prevent CIPN in breast cancer patients.
en-copyright=
kn-copyright=
en-aut-name=YamanouchiKosho
en-aut-sei=Yamanouchi
en-aut-mei=Kosho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KubaSayaka
en-aut-sei=Kuba
en-aut-mei=Sayaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MatsumotoMegumi
en-aut-sei=Matsumoto
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YanoHiroshi
en-aut-sei=Yano
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=MoritaMichi
en-aut-sei=Morita
en-aut-mei=Michi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=SakimuraChika
en-aut-sei=Sakimura
en-aut-mei=Chika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=OtsuboRyota
en-aut-sei=Otsubo
en-aut-mei=Ryota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KanetakaKengo
en-aut-sei=Kanetaka
en-aut-mei=Kengo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=NagayasuTakeshi
en-aut-sei=Nagayasu
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=EguchiSusumu
en-aut-sei=Eguchi
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=
affil-num=2
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=
affil-num=3
en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=
affil-num=4
en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=
affil-num=5
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=
affil-num=6
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=
affil-num=7
en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=
affil-num=8
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=
affil-num=9
en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=
affil-num=10
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=docetaxel
kn-keyword=docetaxel
en-keyword=neuropathy
kn-keyword=neuropathy
en-keyword=compression
kn-keyword=compression
END
start-ver=1.4
cd-journal=joma
no-vol=240
cd-vols=
no-issue=3
article-no=
start-page=032001
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Numerical study of air-entraining and submerged vortices in a pump sump
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Numerical detection of harmful vortices in pump sumps, such as an air-entraining vortex (AEV) and a submerged vortex (SMV), is crucially important to develop the drain pump machinery. We performed numerical simulations of the benchmark experiments of the pump sump conducted by Matsui et al. (2006 and 2016) using the OpenFOAM and compared the simulation results with the experimental data considering the effects of turbulence model, grid density and detection method of the vortices. We studied the threshold of the gas-liquid volume fraction of the VOF method and the second invariant of velocity gradient tensor to identify AEV and SMV. The methods proposed in the present paper were found to be very effective for the detection of the vortices, and the simulation results by RANS with the SST k-omega model successfully reproduced the experimental data. LES with the Smagorinsky model, however, was sensitive to the grid system and difficult to reproduce the experimental data even for the finest grid system having 3.7 million cells in the present study.
en-copyright=
kn-copyright=
en-aut-name=YanaseShinichiro
en-aut-sei=Yanase
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=YamasakiRyo
en-aut-sei=Yamasaki
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KouchiToshinori
en-aut-sei=Kouchi
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=HosodaShunsuke
en-aut-sei=Hosoda
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NagataYasunori
en-aut-sei=Nagata
en-aut-mei=Yasunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=ShunjiHiguchi
en-aut-sei=Shunji
en-aut-mei=Higuchi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KawabeToshihiko
en-aut-sei=Kawabe
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=TakamiToshihiro
en-aut-sei=Takami
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
affil-num=1
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=
affil-num=2
en-affil=Technical Division, Tsurumi Manufacturing Co.
kn-affil=
affil-num=3
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=
affil-num=4
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=
affil-num=5
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=
affil-num=6
en-affil=Technical Division, Tsurumi Manufacturing Co.
kn-affil=
affil-num=7
en-affil=Technical Division, Tsurumi Manufacturing Co.
kn-affil=
affil-num=8
en-affil=Department of Mechanical and Systems Engineering, Okayama University of Science
kn-affil=
END
start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=3
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190603
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Solid-state nuclear magnetic resonance study of setting mechanism of beta-tricalcium phosphate-inositol phosphate composite cements
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Solid-state nuclear magnetic resonance (NMR) spectroscopy is a technique, which can be used to provide insight into the chemical structure of non-crystalline and crystalline materials. Hence, the present study aimed to elucidate the setting mechanism of CPC, which was fabricated using beta -tricalcium phosphate (beta -TCP)-inositol phosphate (IP6) composite powder using NMR In addition, the effect of IP6 on the local chemical structure of the beta -TCP-IP6 composite powder and its hardened cement would also be investigated. The H-1 -> P-31 heteronuclear correlation NMR spectrum revealed that an amorphous hydrated layer, along with small amount of hydroxyapatite (HA) was formed on the surface of beta -TCP during the ball-milling process. Results demonstrated that the IP6 in the hydrated layer on the surface of beta -TCP inhibited the formation of HA. Moreover, the setting reaction of the cement was mainly triggered by the dissolution of the amorphous hydrated layer on beta -TCP surface, and subsequent precipitation, followed by the inter-entanglement between the HA crystals on the beta -TCP.
en-copyright=
kn-copyright=
en-aut-name=KonishiToshiisa
en-aut-sei=Konishi
en-aut-mei=Toshiisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=YamashitaKohei
en-aut-sei=Yamashita
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NagataKohei
en-aut-sei=Nagata
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=LimPoon Nian
en-aut-sei=Lim
en-aut-mei=Poon Nian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=ThianEng San
en-aut-sei=Thian
en-aut-mei=Eng San
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=AizawaMamoru
en-aut-sei=Aizawa
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
affil-num=3
en-affil=Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University
kn-affil=
affil-num=4
en-affil=Department of Mechanical Engineering, National University of Singapore
kn-affil=
affil-num=5
en-affil=Department of Mechanical Engineering, National University of Singapore
kn-affil=
affil-num=6
en-affil=Department of Applied Chemistry, School of Science and Technology, Meiji University
kn-affil=
en-keyword=beta-tricalcium phosphate
kn-keyword=beta-tricalcium phosphate
en-keyword=calcium-phosphate cement
kn-keyword=calcium-phosphate cement
en-keyword=inositol phosphate
kn-keyword=inositol phosphate
en-keyword=solid-state NMR
kn-keyword=solid-state NMR
en-keyword=setting mechanism
kn-keyword=setting mechanism
END
start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=2
article-no=
start-page=103
end-page=108
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Switching from Treatment with Amlodipine and Atorvastatin Using Two Pills to an Equal Dose of Single-Pill Therapy in Japanese Outpatients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal dose of single-pill therapy, whereas low-density lipoprotein (LDL) cholesterol levels significantly decreased after the medication was switched from 94±24 mg/dl to 89±17 mg/dl (p=0.015). A switch from medication with two separate pills of amlodipine and atorvastatin to an equal dose of single-pill therapy resulted in an overall decrease in LDL cholesterol. The results indicated that the switch to single-pill therapy might be a useful treatment.
en-copyright=
kn-copyright=
en-aut-name=KawadaYasumasa
en-aut-sei=Kawada
en-aut-mei=Yasumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KuboToru
en-aut-sei=Kubo
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=BabaYuichi
en-aut-sei=Baba
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=HirotaTakayoshi
en-aut-sei=Hirota
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=TaniokaKatsutoshi
en-aut-sei=Tanioka
en-aut-mei=Katsutoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=YamasakiNaohito
en-aut-sei=Yamasaki
en-aut-mei=Naohito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KitaokaHiroaki
en-aut-sei=Kitaoka
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=
affil-num=2
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=
affil-num=3
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=
affil-num=4
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=
affil-num=5
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=
affil-num=6
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=
affil-num=7
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=
en-keyword=hypertension
kn-keyword=hypertension
en-keyword=dyslipidemia
kn-keyword=dyslipidemia
en-keyword=single-pill therapy
kn-keyword=single-pill therapy
END
start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4
article-no=
start-page=367
end-page=372
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
en-copyright=
kn-copyright=
en-aut-name=Mifune-MoriokaTomoyo
en-aut-sei=Mifune-Morioka
en-aut-mei=Tomoyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=A. UchidaHaruhito
en-aut-sei=A. Uchida
en-aut-mei=Haruhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=FukushimaKazuhiko
en-aut-sei=Fukushima
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=WatanabeMayu
en-aut-sei=Watanabe
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=OuchiChihiro
en-aut-sei=Ouchi
en-aut-mei=Chihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MiseKoki
en-aut-sei=Mise
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KawakitaChieko
en-aut-sei=Kawakita
en-aut-mei=Chieko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KanoYuzuki
en-aut-sei=Kano
en-aut-mei=Yuzuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=OnishiAkifumi
en-aut-sei=Onishi
en-aut-mei=Akifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=TomaKishio
en-aut-sei=Toma
en-aut-mei=Kishio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=EguchiJun
en-aut-sei=Eguchi
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=WadaNozomu
en-aut-sei=Wada
en-aut-mei=Nozomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
en-aut-name=IkedaFusao
en-aut-sei=Ikeda
en-aut-mei=Fusao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=
en-aut-name=SasakiErika
en-aut-sei=Sasaki
en-aut-mei=Erika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=
en-aut-name=SuganamiYu
en-aut-sei=Suganami
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=
en-aut-name=KishidaMasayuki
en-aut-sei=Kishida
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=
en-aut-name=SugiyamaHitoshi
en-aut-sei=Sugiyama
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=
en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=
en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=
affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=4
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=5
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=6
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=7
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=8
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=9
en-affil=Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=10
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=11
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=12
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=13
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=14
en-affil=Department of General Internal Medicine and Endocrinology, Okayama City Hospital
kn-affil=
affil-num=15
en-affil=Department of General Internal Medicine and Endocrinology, Okayama City Hospital
kn-affil=
affil-num=16
en-affil=Department of General Internal Medicine and Endocrinology, Okayama City Hospital
kn-affil=
affil-num=17
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=18
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=19
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=autoimmune polyglandular syndrome type 3
kn-keyword=autoimmune polyglandular syndrome type 3
en-keyword=systemic lupus erythematosus
kn-keyword=systemic lupus erythematosus
en-keyword=autoimmune hepatitis
kn-keyword=autoimmune hepatitis
en-keyword=slowly progressive insulin-dependent diabetes mellitus
kn-keyword=slowly progressive insulin-dependent diabetes mellitus
en-keyword=chronic thyroiditis
kn-keyword=chronic thyroiditis
END
start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4
article-no=
start-page=361
end-page=365
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Case of Primary Colonic Signet Ring Cell Carcinoma in a Young Man which Preoperatively Mimicked Phlebosclerotic Colitis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis.
en-copyright=
kn-copyright=
en-aut-name=WatanabeAyako
en-aut-sei=Watanabe
en-aut-mei=Ayako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KadowakiYoshihiko
en-aut-sei=Kadowaki
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=HattoriKenji
en-aut-sei=Hattori
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=OhmoriMika
en-aut-sei=Ohmori
en-aut-mei=Mika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=TsukayamaHiroyuki
en-aut-sei=Tsukayama
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KubotaNobuhito
en-aut-sei=Kubota
en-aut-mei=Nobuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=OkumotoTatsuo
en-aut-sei=Okumoto
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=IshidoNobuhiro
en-aut-sei=Ishido
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=OkinoTakeshi
en-aut-sei=Okino
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=
affil-num=2
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=
affil-num=3
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=
affil-num=4
en-affil=Department of Radiology, Japanese Red Cross Kobe Hospital
kn-affil=
affil-num=5
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=
affil-num=6
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=
affil-num=7
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=
affil-num=8
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=
affil-num=9
en-affil=Department of Pathology, Japanese Red Cross Kobe Hospital
kn-affil=
en-keyword=phlebosclerotic colitis
kn-keyword=phlebosclerotic colitis
en-keyword=colorectal cancer
kn-keyword=colorectal cancer
en-keyword=signet ring cell carcinoma
kn-keyword=signet ring cell carcinoma
en-keyword=young colorectal cancer
kn-keyword=young colorectal cancer
END
start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4
article-no=
start-page=285
end-page=297
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Dynamic Reorganization of Microtubule and Glioma Invasion
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
en-copyright=
kn-copyright=
en-aut-name=OtaniYoshihiro
en-aut-sei=Otani
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=IchikawaTomotsugu
en-aut-sei=Ichikawa
en-aut-mei=Tomotsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KurozumiKazuhiko
en-aut-sei=Kurozumi
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
affil-num=1
en-affil=Department of Neurosurgery, The University of Texas Health Science Center at Houston
kn-affil=
affil-num=2
en-affil=Department of Neurosurgery, Kagawa Prefectural Central Hospital
kn-affil=
affil-num=3
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=glioma
kn-keyword=glioma
en-keyword=cytoskeletons
kn-keyword=cytoskeletons
en-keyword=invasion
kn-keyword=invasion
en-keyword=microtubules
kn-keyword=microtubules
END
start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=3
article-no=
start-page=263
end-page=267
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sudden, Sharp Turn in an AIDS Patient’s Course Following the Onset of Fulminant Type 1 Diabetes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A previously healthy 40-year-old Japanese male was urgently admitted with a 2-month history of dysphagia, 30-kg weight loss, and fever. Human immunodeficiency virus (HIV) antibodies and cytomegalovirus antigenemia were positive. Pneumocystis pneumonia and cytomegalovirus pneumonia were suspected. The patient was diagnosed with acquired immune deficiency syndrome (AIDS). Cytomegalovirus antigenemia became negative 20 days after the positive result. On hospital day 41, he experienced cardiopulmonary arrest. The clinical diagnosis was fulminant type 1 diabetes mellitus. He later developed hypoglycemia and was diagnosed with adrenal insufficiency accompanied by septic shock. He died of multiple organ failure 29 h post-admission to our ICU.
en-copyright=
kn-copyright=
en-aut-name=ShimoyamaYuichiro
en-aut-sei=Shimoyama
en-aut-mei=Yuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=UmegakiOsamu
en-aut-sei=Umegaki
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=OoiYukimasa
en-aut-sei=Ooi
en-aut-mei=Yukimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=ShigemotoSho
en-aut-sei=Shigemoto
en-aut-mei=Sho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=AguiTomoyuki
en-aut-sei=Agui
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KadonoNoriko
en-aut-sei=Kadono
en-aut-mei=Noriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MinamiToshiaki
en-aut-sei=Minami
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=Department of Intensive Care Unit, Osaka Medical College Hospital
kn-affil=
affil-num=2
en-affil=Department of Intensive Care Unit, Osaka Medical College Hospital
kn-affil=
affil-num=3
en-affil=Department of Internal Medicine, Osaka Medical College Hospital
kn-affil=
affil-num=4
en-affil=Department of Internal Medicine, Osaka Medical College Hospital
kn-affil=
affil-num=5
en-affil=Department of Surgery, Osaka Medical College Hospital
kn-affil=
affil-num=6
en-affil=Department of Intensive Care Unit, Osaka Medical College Hospital
kn-affil=
affil-num=7
en-affil=Department ofAnesthesiology, Osaka Medical College Hospital
kn-affil=
en-keyword=fulminant type 1 diabetes mellitus
kn-keyword=fulminant type 1 diabetes mellitus
en-keyword=human immunodeficiency virus
kn-keyword=human immunodeficiency virus
en-keyword=cytomegalovirus
kn-keyword=cytomegalovirus
en-keyword=hypoglycemia
kn-keyword=hypoglycemia
END
start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS.
en-copyright=
kn-copyright=
en-aut-name=MatsumotoAtsushi
en-aut-sei=Matsumoto
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=NakamuraTakehiro
en-aut-sei=Nakamura
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=ShinomiyaAya
en-aut-sei=Shinomiya
en-aut-mei=Aya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=KawakitaKenya
en-aut-sei=Kawakita
en-aut-mei=Kenya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KawanishiMasahiko
en-aut-sei=Kawanishi
en-aut-mei=Masahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MiyakeKeisuke
en-aut-sei=Miyake
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KurodaYasuhiro
en-aut-sei=Kuroda
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KeepRichard F.
en-aut-sei=Keep
en-aut-mei=Richard F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=TamiyaTakashi
en-aut-sei=Tamiya
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
affil-num=1
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=
affil-num=2
en-affil=Department of Medical Technology, Kagawa Prefectural University of Health Sciences
kn-affil=
affil-num=3
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=
affil-num=4
en-affil=Emergency Medical Center, Kagawa University Hospital
kn-affil=
affil-num=5
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=
affil-num=6
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=
affil-num=7
en-affil=Emergency Medical Center, Kagawa University Hospital
kn-affil=
affil-num=8
en-affil=Department of Neurosurgery, University of Michigan
kn-affil=
affil-num=9
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=
en-keyword=biomarker
kn-keyword=biomarker
en-keyword=histidine-rich glycoprotein
kn-keyword=histidine-rich glycoprotein
en-keyword=predictor
kn-keyword=predictor
en-keyword=subarachnoid hemorrhage
kn-keyword=subarachnoid hemorrhage
en-keyword=vasospasm
kn-keyword=vasospasm
END
start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=1
article-no=
start-page=21
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Clitoral Blood Flow Changes after Surgery with Tension-Free Vaginal Mesh for Pelvic Organ Prolapse
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We measured basal clitoral blood flow by Doppler sonography to determine whether tension-free vaginal mesh(TVM) affects the clitoral blood flow and sexual function in women with pelvic organ prolapse (POP). We performed a prospective study of 22 patients who underwent TVM for POP. Clitoral blood flow was measured by Doppler ultrasound. The resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) of the clitoral arteries were measured preoperatively and at 1, 3, and 6 months postoperatively. Female sexual function was also investigated with the Female Sexual Function Index (FSFI). The mean PI and RI were increased at 1 month and significantly decreased at 6 months postoperatively (p<0.05). In contrast, the mean PSV and EDV decreased at 1 month postoperatively and increased at 6 months postoperatively. These four parameters recovered to baseline levels at 6 months following surgery. Total FSFI scores improved significantly from 10.2±7.9 at baseline to 18.2±8.9 at 6 months postoperatively. Color Doppler ultrasonography is potentially useful in measuring clitoral blood flow in patients treated with TVM for POP. Prospective long-term studies are needed to evaluate the utility of this modality as a diagnostic and prognostic tool for female sexual dysfunction.
en-copyright=
kn-copyright=
en-aut-name=OiwaYuko
en-aut-sei=Oiwa
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=WatanabeToyohiko
en-aut-sei=Watanabe
en-aut-mei=Toyohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SadahiraTakuya
en-aut-sei=Sadahira
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=IshiiAyano
en-aut-sei=Ishii
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SakoTomoko
en-aut-sei=Sako
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=InoueMiyabi
en-aut-sei=Inoue
en-aut-mei=Miyabi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=WadaKoichiro
en-aut-sei=Wada
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KobayashiYasuyuki
en-aut-sei=Kobayashi
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=ArakiMotoo
en-aut-sei=Araki
en-aut-mei=Motoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=NasuYasutomo
en-aut-sei=Nasu
en-aut-mei=Yasutomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=2
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=3
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=4
en-affil=Integrated Support Center for Patients and Self-learning, Okayama University Hospital
kn-affil=
affil-num=5
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=6
en-affil=Miyabi Urogyne Clinic
kn-affil=
affil-num=7
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=8
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=9
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
affil-num=10
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=clitoris
kn-keyword=clitoris
en-keyword=pelvic organ prolapse
kn-keyword=pelvic organ prolapse
en-keyword=Doppler ultrasound
kn-keyword=Doppler ultrasound
END
start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=845
article-no=
start-page=16-00441
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=2017
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Large-scale vortical structure detection using microphone array in a semiconductor single wafer spin cleaner
kn-title=マイクロフォンアレイを用いた枚葉式半導体洗浄装置内に形成される大規模渦構造の検出
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Fluctuating pressure (p’ ) of a large-scale vortical structure generated in a semiconductor single wafer spin cleaner was detected by using microphone array. Twelve microphones were installed on the exhaust cover under the rotating disk of the cleaner with their interval of 7.5° or 15°. Power spectrum densities (PSD) of p’ were compared with those of fluctuating velocity measured by PIV for various rotation angular velocities to identify fluctuations due to convection of the large-scale vortical structure. Good agreement of PSDs indicates that the large-scale structure could be detected by using microphone. Cross-correlation of p’ measured at different positions revealed that the large-scale structure convected to the downstream in the rotational direction of the disk. The convection speed was about 12 % of the angular velocity of the rotating disk. Number of the vortex in the large-scale structure was also evaluated from the time-series p’ data. Time-space contour map was made for p’ based on the data measured at the different angular position, and showed periodical swept strip patterns. Presences of the strip patterns indicate the pressure disturbances were stably convected to the downstream. From this time-space map, two-dimensional Fourier transform efficiently extracted the number of vortices in the large-scale structure.
en-copyright=
kn-copyright=
en-aut-name=KOUCHIToshinori
en-aut-sei=KOUCHI
en-aut-mei=Toshinori
kn-aut-name=河内俊憲
kn-aut-sei=河内
kn-aut-mei=俊憲
aut-affil-num=1
ORCID=
en-aut-name=MIYOSHIYuki
en-aut-sei=MIYOSHI
en-aut-mei=Yuki
kn-aut-name=三好勇輝
kn-aut-sei=三好
kn-aut-mei=勇輝
aut-affil-num=2
ORCID=
en-aut-name=NAKANOYusuke
en-aut-sei=NAKANO
en-aut-mei=Yusuke
kn-aut-name=中野裕介
kn-aut-sei=中野
kn-aut-mei=裕介
aut-affil-num=3
ORCID=
en-aut-name=NAGATAYasunori
en-aut-sei=NAGATA
en-aut-mei=Yasunori
kn-aut-name=永田靖典
kn-aut-sei=永田
kn-aut-mei=靖典
aut-affil-num=4
ORCID=
en-aut-name=YANASEShinichiro
en-aut-sei=YANASE
en-aut-mei=Shinichiro
kn-aut-name=柳瀬眞一郎
kn-aut-sei=柳瀬
kn-aut-mei=眞一郎
aut-affil-num=5
ORCID=
affil-num=1
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=2
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=3
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=4
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=5
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
en-keyword=Rotating disk
kn-keyword=Rotating disk
en-keyword=Flow stability
kn-keyword=Flow stability
en-keyword=Coherent structure
kn-keyword=Coherent structure
en-keyword=Differential pressure measurement
kn-keyword=Differential pressure measurement
END
start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=829
article-no=
start-page=15-00273
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=2015
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Periodical structure of vortices in a semiconductor single wafer spin cleaner
kn-title=枚葉式半導体洗浄装置内に形成される渦の周期構造
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We experimentally and numerically investigated large-scale structures formed by vortices in a single wafer spin cleaner. The Q-criterion identified the vortices developed in the cleaner as the flow regions with positive second invariant of the velocity gradient tensor obtained by both the PIV and LES. The time-series two-components PIV data shows that small-vortices were clustered near and under the edge of the rotating disk and were periodically emanated from there to the housing wall of the cleaner. The emanation frequency was increased with increasing in the angular velocity of the rotating disk. Three-dimensional LES reveal that six longitudinal vortices were spirally developed from under the edge of the rotating disk to the housing wall. This structure stably rotated slower than the disk speed. Fourier analysis of the LES data agreed with that of the PIV data. This supports that the passages of the stable spiral vortices on the PIV measurement region resulted in the periodical emanation of the clustered small-vortices observed in the PIV. Such a very large-scale spiral structure will induce reattachment of contaminants on the wafer surface, and should be destructed for development of much higher efficient cleaner.
en-copyright=
kn-copyright=
en-aut-name=KOUCHIToshinori
en-aut-sei=KOUCHI
en-aut-mei=Toshinori
kn-aut-name=河内俊憲
kn-aut-sei=河内
kn-aut-mei=俊憲
aut-affil-num=1
ORCID=
en-aut-name=FUKUDANaoya
en-aut-sei=FUKUDA
en-aut-mei=Naoya
kn-aut-name=福田修也
kn-aut-sei=福田
kn-aut-mei=修也
aut-affil-num=2
ORCID=
en-aut-name=NAKANOYusuke
en-aut-sei=NAKANO
en-aut-mei=Yusuke
kn-aut-name=中野裕介
kn-aut-sei=中野
kn-aut-mei=裕介
aut-affil-num=3
ORCID=
en-aut-name=SHIMIZUYoshiya
en-aut-sei=SHIMIZU
en-aut-mei=Yoshiya
kn-aut-name=清水義也
kn-aut-sei=清水
kn-aut-mei=義也
aut-affil-num=4
ORCID=
en-aut-name=NAGATAYasunori
en-aut-sei=NAGATA
en-aut-mei=Yasunori
kn-aut-name=永田靖典
kn-aut-sei=永田
kn-aut-mei=靖典
aut-affil-num=5
ORCID=
en-aut-name=YANASEShinichiro
en-aut-sei=YANASE
en-aut-mei=Shinichiro
kn-aut-name=柳瀬眞一郎
kn-aut-sei=柳瀬
kn-aut-mei=眞一郎
aut-affil-num=6
ORCID=
affil-num=1
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=2
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=3
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=4
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=5
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=6
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
en-keyword=Rotating disk
kn-keyword=Rotating disk
en-keyword=Flow stability
kn-keyword=Flow stability
en-keyword=Large-scale structure
kn-keyword=Large-scale structure
en-keyword=PIV
kn-keyword=PIV
en-keyword=LES
kn-keyword=LES
END
start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=853
article-no=
start-page=17-00181
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=2017
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=OpenFOAM analysis of air-entraining and submerged vortices in pump sump
kn-title=OpenFOAMを用いたポンプ水槽内に発生する空気吸込渦と水中渦の解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=YAMASAKIRyo
en-aut-sei=YAMASAKI
en-aut-mei=Ryo
kn-aut-name=山崎諒
kn-aut-sei=山崎
kn-aut-mei=諒
aut-affil-num=1
ORCID=
en-aut-name=KOUCHIToshinori
en-aut-sei=KOUCHI
en-aut-mei=Toshinori
kn-aut-name=河内俊憲
kn-aut-sei=河内
kn-aut-mei=俊憲
aut-affil-num=2
ORCID=
en-aut-name=NAGATAYasunori
en-aut-sei=NAGATA
en-aut-mei=Yasunori
kn-aut-name=永田靖典
kn-aut-sei=永田
kn-aut-mei=靖典
aut-affil-num=3
ORCID=
en-aut-name=YANASEShinichiro
en-aut-sei=YANASE
en-aut-mei=Shinichiro
kn-aut-name=柳瀬眞一郎
kn-aut-sei=柳瀬
kn-aut-mei=眞一郎
aut-affil-num=4
ORCID=
affil-num=1
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=2
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=3
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
affil-num=4
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=岡山大学大学院 自然科学研究科
en-keyword=CFD
kn-keyword=CFD
en-keyword=VOF
kn-keyword=VOF
en-keyword=Turbulance model
kn-keyword=Turbulance model
en-keyword=Grid convergence
kn-keyword=Grid convergence
en-keyword=Vortex detection scheme
kn-keyword=Vortex detection scheme
END
start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=5
article-no=
start-page=427
end-page=432
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Direct Damage to a Vertebral Artery Better Predicts a Vertebral Artery Injury than Elongation in Cervical Spine Dislocation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Cervical spine dislocation and fracture of a transverse process are isolated risk factors for vertebral artery injuries (VAIs), which can cause a life-threatening ischemic stroke. Since in vivo experiments are not possible, it has not been unclear whether damage to or extension of vertebral arteries is more predictive of a VAI. To identify the imaging characteristics associated with VAI, we analyzed 36 vertebral arteries from 22 cervical spine dislocation patients who underwent computed tomography angiography (Aug. 2008-Dec. 2014). We evaluated (1) the posttraumatic elongation of the vertebral artery and (2) the presence of fracture involving the transverse foramen. VAI was found in 20 (56%) of the 36 vertebral arteries. The rate of residual shift (vertebral artery elongation) was not markedly different between the VAI and no-VAI groups. However, the rate of >1 mm displacement into the foramen and that of fracture with gross displacement (≥2 mm) differed significantly between the groups. We found that greater displacement of fractured transverse processes with cervical spine dislocation was a risk factor for VAI. These results suggest that direct damage to the vertebral arteries by transverse process fragments is more likely to predict a VAI compared to elongation, even in cervical spine dislocation.
en-copyright=
kn-copyright=
en-aut-name=NagataKosei
en-aut-sei=Nagata
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=ChikudaHirotaka
en-aut-sei=Chikuda
en-aut-mei=Hirotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=InokuchiKoichi
en-aut-sei=Inokuchi
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=IshiiKeisuke
en-aut-sei=Ishii
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=KobayashiAtsuki
en-aut-sei=Kobayashi
en-aut-mei=Atsuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KanaiHiroyuki
en-aut-sei=Kanai
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=MiyoshiKota
en-aut-sei=Miyoshi
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=Department of Orthopaedic Surgery and Spinal Surgery, The University of Tokyo Hospital
kn-affil=
affil-num=2
en-affil=Department of Orthopaedic Surgery and Spinal Surgery, The University of Tokyo Hospital
kn-affil=
affil-num=3
en-affil=Advanced Critical Care Center, Saitama Medical Center, Saitama Medical University
kn-affil=
affil-num=4
en-affil=Department of Orthopaedic Surgery, Tokyo Metropolitan Bokutoh Hospital
kn-affil=
affil-num=5
en-affil=Department of Orthopaedic Surgery, Tokyo Metropolitan Bokutoh Hospital
kn-affil=
affil-num=6
en-affil=Department of Orthopaedic Surgery, Tokyo Metropolitan Bokutoh Hospital
kn-affil=
affil-num=7
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=
en-keyword=vertebral artery injury
kn-keyword=vertebral artery injury
en-keyword=cervical spine dislocation
kn-keyword=cervical spine dislocation
en-keyword=CT angiography
kn-keyword=CT angiography
en-keyword=transverse process
kn-keyword=transverse process
en-keyword=vertebral artery elongation
kn-keyword=vertebral artery elongation
END
start-ver=1.4
cd-journal=joma
no-vol=129
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=22
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170403
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Sexual function before and after a tension-free vaginal mesh procedure for pelvic organ prolapse
kn-title=骨盤臓器脱に対するTVM 手術前後の性機能に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We prospectively assessed sexual function before and after a tension-free vaginal mesh ( TVM) procedure for pelvic organ prolapse ( POP) . From April 2007 to March 2009, a total of 42 patients, who reported having an active sex life preoperatively underwent TVM for POP. Female sexual function was evaluated with the self-reporting, multiple-domain Female Sexual Function Index (FSFI) . We administered the FSFI to all of the patients before and at 3, 6, and 12 months after surgery. The mean age at surgery was 61.3±7.1 years. Before the TVM surgery, the FSFI score was very low ( 12.5±9.0) . The total FSFI score was improved significantly at 12 months after surgery ( 17.4±7.7) . The Arousal, Lubrication and Orgasm domains were significantly improved at 12 months after surgery. POP appears to have a significant negative impact on female sexual function. Our findings indicate that TVM for POP improved sexual function in a group of Japanese women with POP.
en-copyright=
kn-copyright=
en-aut-name=MatsumotoYuko
en-aut-sei=Matsumoto
en-aut-mei=Yuko
kn-aut-name=松本裕子
kn-aut-sei=松本
kn-aut-mei=裕子
aut-affil-num=1
ORCID=
affil-num=1
en-affil=Department of Urology, Okayama University Graduate School of Medicne, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科 泌尿器病態学
en-keyword=骨盤臓器脱 (pelvic organ prolapse)
kn-keyword=骨盤臓器脱 (pelvic organ prolapse)
en-keyword=TVM (tension-free vaginal mesh)
kn-keyword=TVM (tension-free vaginal mesh)
en-keyword=女性泌尿器科 (female urology)
kn-keyword=女性泌尿器科 (female urology)
en-keyword=性機能 (sexual function)
kn-keyword=性機能 (sexual function)
END
start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=4
article-no=
start-page=261
end-page=268
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201608
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Diagnostic Algorithm for Eosinophilic Granulomatosis with Polyangiitis Initially Diagnosed as Lumbar Disc Hernia or Lumbar Spinal Stenosis: Personal Experience and Review of the Literature
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome) is a rare systemic vasculitis and is difficult to diagnose. EGPA has a number of symptoms including peripheral dysesthesia caused by mononeuropathy multiplex, which is similar to radiculopathy due to lumbar disc hernia or lumbar spinal stenosis. Therefore, EGPA patients with mononeuropathy multiplex often visit orthopedic clinics, but orthopedic doctors and spine neurosurgeons have limited experience in diagnosing EGPA because of its rarity. We report a consecutive series of patients who were initially diagnosed as having lumbar disc hernia or lumbar spinal stenosis by at least 2 medical institutions from March 2006 to April 2013 but whose final diagnosis was EGPA. All patients had past histories of asthma or eosinophilic pneumonia, and four out of five had peripheral edema. Laboratory data showed abnormally increased eosinophil counts, and nerve conduction studies of all patients revealed axonal damage patterns. All patients recovered from paralysis to a functional level after high-dose steroid treatment. We shortened the duration of diagnosis from 49 days to one day by adopting a diagnostic algorithm after experiencing the first case.
en-copyright=
kn-copyright=
en-aut-name=NagataKosei
en-aut-sei=Nagata
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=YamamotoShinichi
en-aut-sei=Yamamoto
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MiyoshiKota
en-aut-sei=Miyoshi
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=SatoMasaki
en-aut-sei=Sato
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=ArinoYusuke
en-aut-sei=Arino
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=MikamiYoji
en-aut-sei=Mikami
en-aut-mei=Yoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=
affil-num=2
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=
affil-num=3
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=
affil-num=4
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=
affil-num=5
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=
affil-num=6
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=
en-keyword=eosinophilic granulomatosis with polyangiitis
kn-keyword=eosinophilic granulomatosis with polyangiitis
en-keyword=mononeuropathy multiplex
kn-keyword=mononeuropathy multiplex
en-keyword=lumbar disc hernia
kn-keyword=lumbar disc hernia
en-keyword=lumbar spinal stenosis
kn-keyword=lumbar spinal stenosis
en-keyword=nerve conduction study
kn-keyword=nerve conduction study
END
start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=2
article-no=
start-page=95
end-page=97
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2015 Incentive Award of the Okayama Medical Association in Neuroscience (2015 Niimi Prize)
kn-title=平成27年度岡山医学会賞 脳神経研究奨励賞（新見賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=ToyoshimaAtsuhiko
en-aut-sei=Toyoshima
en-aut-mei=Atsuhiko
kn-aut-name=豊嶋敦彦
kn-aut-sei=豊嶋
kn-aut-mei=敦彦
aut-affil-num=1
ORCID=
affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Hospital
kn-affil=岡山大学病院 脳神経外科
END
start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=1
article-no=
start-page=141
end-page=158
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201601
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Alternative approach for Siegel's lemma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this article, we present an alternative approach to show a generalization of Siegel's lemma which is an essential tool in Diophantine problems. Our main statement contains the so-called analytic Siegel's lemma as well as the Bombieri-Vaaler lemma. Our proof avoids relying on the ordinary geometry of numbers.
en-copyright=
kn-copyright=
en-aut-name=NagataMakoto
en-aut-sei=Nagata
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=Osaka University of Pharmaceutical Sciences
en-keyword=Siegel’s lemma
kn-keyword=Siegel’s lemma
en-keyword=geometry of numbers
kn-keyword=geometry of numbers
en-keyword=height
kn-keyword=height
END
start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=93
end-page=100
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study of developing a teaching program for a voter education from an elementary school to a high school Based on developing a tentative lesson plan of an elementary social studies in order to teach about vote
kn-title=小中高一貫有権者教育プログラム開発の方法（１）:「選挙」をテーマとする小学校社会科の単元の開発を通して
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 本研究は，市民社会に寄与し得る有権者の育成を目指し，児童・生徒の発達段階に応じた有権者教育のあり方
を追究して，小学校から高等学校までの12 年間を一貫する原理にもとづいた有権者教育プログラム開発のため
の原理と方法を解明しようとするものである。そのために，第一に，子どもたちの政治に対する認識調査を行い，
子どもたちが政治的な概念についてどのような認識を持っており，それを教育によってどの程度まで変容させる
ことができるかを明らかにした。そして，第二に，その調査の結果と従来の政治教育研究の成果をふまえて，有
権者教育のための小中高一貫カリキュラム・フレームワークを提示した。それに基づいて，第三に，具体的な単
元開発を行った。単元は，「選挙」，「議会」，「税金」という政治学の基本的概念をテーマとして取り上げて開発
したが，本稿では「選挙」概念をテーマとして開発した小学校社会科の単元を紹介する。
en-copyright=
kn-copyright=
en-aut-name=KuwabaraToshinori
en-aut-sei=Kuwabara
en-aut-mei=Toshinori
kn-aut-name=桑原敏典
kn-aut-sei=桑原
kn-aut-mei=敏典
aut-affil-num=1
ORCID=
en-aut-name=KudoBunzo
en-aut-sei=Kudo
en-aut-mei=Bunzo
kn-aut-name=工藤文三
kn-aut-sei=工藤
kn-aut-mei=文三
aut-affil-num=2
ORCID=
en-aut-name=TanahashiKenji
en-aut-sei=Tanahashi
en-aut-mei=Kenji
kn-aut-name=棚橋健治
kn-aut-sei=棚橋
kn-aut-mei=健治
aut-affil-num=3
ORCID=
en-aut-name=YatabeReio
en-aut-sei=Yatabe
en-aut-mei=Reio
kn-aut-name=谷田部玲生
kn-aut-sei=谷田部
kn-aut-mei=玲生
aut-affil-num=4
ORCID=
en-aut-name=KoyamaShigeki
en-aut-sei=Koyama
en-aut-mei=Shigeki
kn-aut-name=小山茂喜
kn-aut-sei=小山
kn-aut-mei=茂喜
aut-affil-num=5
ORCID=
en-aut-name=YoshimuraKotaro
en-aut-sei=Yoshimura
en-aut-mei=Kotaro
kn-aut-name=吉村功太郎
kn-aut-sei=吉村
kn-aut-mei=功太郎
aut-affil-num=6
ORCID=
en-aut-name=OshiharaSusumu
en-aut-sei=Oshihara
en-aut-mei=Susumu
kn-aut-name=鴛原進
kn-aut-sei=鴛原
kn-aut-mei=進
aut-affil-num=7
ORCID=
en-aut-name=NagataTadamichi
en-aut-sei=Nagata
en-aut-mei=Tadamichi
kn-aut-name=永田忠道
kn-aut-sei=永田
kn-aut-mei=忠道
aut-affil-num=8
ORCID=
en-aut-name=HashimotoYasuhiro
en-aut-sei=Hashimoto
en-aut-mei=Yasuhiro
kn-aut-name=橋本康弘
kn-aut-sei=橋本
kn-aut-mei=康弘
aut-affil-num=9
ORCID=
en-aut-name=WatanabeTatsuya
en-aut-sei=Watanabe
en-aut-mei=Tatsuya
kn-aut-name=渡部竜也
kn-aut-sei=渡部
kn-aut-mei=竜也
aut-affil-num=10
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科
affil-num=2
en-affil=
kn-affil=帝塚山学院大学人間科学部
affil-num=3
en-affil=
kn-affil=広島大学大学院教育学研究科
affil-num=4
en-affil=
kn-affil=桐蔭横浜大学法学部
affil-num=5
en-affil=
kn-affil=信州大学全学教育機構
affil-num=6
en-affil=
kn-affil=宮崎大学大学院教育学研究科
affil-num=7
en-affil=
kn-affil=愛媛大学教育学部
affil-num=8
en-affil=
kn-affil=広島大学大学院教育学研究科
affil-num=9
en-affil=
kn-affil=福井大学教育地域科学部
affil-num=10
en-affil=
kn-affil=東京学芸大学教育学部
en-keyword=有権者教育
kn-keyword=有権者教育
en-keyword=小中高一貫
kn-keyword=小中高一貫
en-keyword=カリキュラム・フレームワーク
kn-keyword=カリキュラム・フレームワーク
en-keyword=小学校社会科
kn-keyword=小学校社会科
en-keyword=単元開発
kn-keyword=単元開発
END
start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=
article-no=
start-page=5
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=好酸性鉄酸化細菌 Acidithiobacillus ferrooxidans の染色体凝集・分配タンパク質（ScpB）の性質
kn-title=Characterization of a putative chromosome segregation and condensation protein (ScpB) in an acidophilic iron‒oxidizing bacterium Acidithiobacillus ferrooxidans
en-subtitle=
kn-subtitle=
en-abstract= Acidithiobacillus ferrooxidans は，低品位の銅鉱石から銅を回収するバイオリーチングにおいて使用される微生物
の一つである．この細菌は，エネルギー源として二価鉄イオンや還元型無機硫黄化合物（RISC）を使用する．鉄の酸化に関与する遺伝子の転写は，A. ferrooxidans が RISC で生育したときには抑制されるが，RISC の酸化に関与すると考えられている遺伝子の転写は活性化されることが知られている．硫黄やテトラチオン酸で生育したときにその発現が上方制御される硫化水素：キノン酸化還元酵素のすぐ上流に，ヘリックスターンへリックスモティーフを持つ，ScpB と推定されるタンパク質をコードする遺伝子が存在していた．鉄，硫黄，テトラチオン酸生育細胞から調製した cDNA を用いた半定量的 PCR 分析の結果，硫黄やテトラチオン酸で生育した細胞内の scpB 遺伝子の転写は，鉄生育細胞と比較すると上方制御されていた．組換え ScpB タンパク質を用いたゲルシフトアッセイ法で，ScpB
が転写制御因子として機能するかどうかを調べた．その結果，ScpB は DNA に結合したが，結合の特異性はなかった．ScpB が直接 DNA と相互作用する報告はこれまでになかった．
kn-abstract= Acidithiobacillus ferrooxidans is one of the most widely used microorganisms in bioleaching operations to recover copper from low-grade copper sulfide. This bacterium uses ferrous iron and reduced inorganic sulfur compounds (RISCs) as energy sources. Transcriptions of genes thought to be involved in the oxidation of RISCs have been known to be highly activated in A. ferrooxidans cells grown on RISCs, while transcriptions of genes involved in the iron oxidation were repressed in the cells grown on
RISCs. A gene encoding a putative chromosome segregation and condensation protein (ScpB) with a
helix-turn-helix motif was found in the upstream region of sulfide : quinone oxidoreductase gene, whose expression was up-regulated in cells grown in sulfur and tetrathionate. A semi-quantitative PCR analysis using cDNA prepared from iron-, sulfur-, or tetrathionate-grown cells revealed that the transcription of scpB was up-regulated in cells grown on sulfur or tetrathionate as the energy source. Electrophoretic mobility shift assays were employed to examine whether the ScpB functions as a transcription factor. The result indicated that the recombinant His-tagged ScpB protein was able to nonspecifically bind in
vitro to DNA. This is the first report on a direct association of ScpB with DNA.
en-copyright=
kn-copyright=
en-aut-name=KamimuraKazuo
en-aut-sei=Kamimura
en-aut-mei=Kazuo
kn-aut-name=上村一雄
kn-aut-sei=上村
kn-aut-mei=一雄
aut-affil-num=1
ORCID=
en-aut-name=NagataNozomu
en-aut-sei=Nagata
en-aut-mei=Nozomu
kn-aut-name=長田臨
kn-aut-sei=長田
kn-aut-mei=臨
aut-affil-num=2
ORCID=
en-aut-name=KikumotoMei
en-aut-sei=Kikumoto
en-aut-mei=Mei
kn-aut-name=菊本愛生
kn-aut-sei=菊本
kn-aut-mei=愛生
aut-affil-num=3
ORCID=
en-aut-name=SharminSultana
en-aut-sei=Sharmin
en-aut-mei=Sultana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=WakaiSatoshi
en-aut-sei=Wakai
en-aut-mei=Satoshi
kn-aut-name=若井暁
kn-aut-sei=若井
kn-aut-mei=暁
aut-affil-num=5
ORCID=
en-aut-name=KanaoTadayoshi
en-aut-sei=Kanao
en-aut-mei=Tadayoshi
kn-aut-name=金尾忠芳
kn-aut-sei=金尾
kn-aut-mei=忠芳
aut-affil-num=6
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院環境生命科学研究科
affil-num=2
en-affil=
kn-affil=岡山大学大学院環境生命科学研究科
affil-num=3
en-affil=
kn-affil=岡山大学大学院環境生命科学研究科
affil-num=4
en-affil=
kn-affil=岡山大学大学院環境生命科学研究科
affil-num=5
en-affil=
kn-affil=神戸大学自然科学系先端融合研究環
affil-num=6
en-affil=
kn-affil=神戸大学自然科学系先端融合研究環
en-keyword=Acidithiobacillus ferrooxidans
kn-keyword=Acidithiobacillus ferrooxidans
en-keyword=Acidophile
kn-keyword=Acidophile
en-keyword=ScpB
kn-keyword=ScpB
en-keyword=transcription factor
kn-keyword=transcription factor
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=層状希土類複電荷鉄酸化物YbFe2O4単結晶の電荷秩序形成による強誘電性とその対称性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NagataTomoko
en-aut-sei=Nagata
en-aut-mei=Tomoko
kn-aut-name=永田知子
kn-aut-sei=永田
kn-aut-mei=知子
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学
END
start-ver=1.4
cd-journal=joma
no-vol=155
cd-vols=
no-issue=
article-no=
start-page=109
end-page=113
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Junior High School Female Teachers’ Negative Feelings and Embarrassment toward Dance
kn-title=中学校女性体育教員のダンスに対する抵抗感と羞恥心について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=SakoHaruko
en-aut-sei=Sako
en-aut-mei=Haruko
kn-aut-name=酒向治子
kn-aut-sei=酒向
kn-aut-mei=治子
aut-affil-num=1
ORCID=
en-aut-name=NagataMariko
en-aut-sei=Nagata
en-aut-mei=Mariko
kn-aut-name=永田麻里子
kn-aut-sei=永田
kn-aut-mei=麻里子
aut-affil-num=2
ORCID=
en-aut-name=IzakiYayoi
en-aut-sei=Izaki
en-aut-mei=Yayoi
kn-aut-name=猪崎弥生
kn-aut-sei=猪崎
kn-aut-mei=弥生
aut-affil-num=3
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科 生活・健康スポーツ学系 保健体育講座
affil-num=2
en-affil=
kn-affil=お茶の水女子大学
affil-num=3
en-affil=
kn-affil=お茶の水女子大学
en-keyword=ダンス
kn-keyword=ダンス
en-keyword=抵抗感
kn-keyword=抵抗感
en-keyword=羞恥心
kn-keyword=羞恥心
END
start-ver=1.4
cd-journal=joma
no-vol=154
cd-vols=
no-issue=
article-no=
start-page=73
end-page=77
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20131125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Gender Bias in the Dance Image of Junior High School Students
kn-title=中学生のダンスに対するジェンダー・バイアス
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=SakoHaruko
en-aut-sei=Sako
en-aut-mei=Haruko
kn-aut-name=酒向治子
kn-aut-sei=酒向
kn-aut-mei=治子
aut-affil-num=1
ORCID=
en-aut-name=NagataMariko
en-aut-sei=Nagata
en-aut-mei=Mariko
kn-aut-name=永田麻里子
kn-aut-sei=永田
kn-aut-mei=麻里子
aut-affil-num=2
ORCID=
en-aut-name=IdeharaChinami
en-aut-sei=Idehara
en-aut-mei=Chinami
kn-aut-name=出原智波
kn-aut-sei=出原
kn-aut-mei=智波
aut-affil-num=3
ORCID=
en-aut-name=YamaguchiJunko
en-aut-sei=Yamaguchi
en-aut-mei=Junko
kn-aut-name=山口順子
kn-aut-sei=山口
kn-aut-mei=順子
aut-affil-num=4
ORCID=
en-aut-name=IzakiYayoi
en-aut-sei=Izaki
en-aut-mei=Yayoi
kn-aut-name=猪崎弥生
kn-aut-sei=猪崎
kn-aut-mei=弥生
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科 生活・健康スポーツ学系 保健体育講座
affil-num=2
en-affil=
kn-affil=お茶の水女子大学
affil-num=3
en-affil=
kn-affil=
affil-num=4
en-affil=
kn-affil=岡山大学教育学部附属中学校
affil-num=5
en-affil=
kn-affil=お茶の水女子大学
en-keyword=ダンス
kn-keyword=ダンス
en-keyword=ジェンダー・イメージ
kn-keyword=ジェンダー・イメージ
en-keyword=ジェンダー・バイアス
kn-keyword=ジェンダー・バイアス
END
start-ver=1.4
cd-journal=joma
no-vol=153
cd-vols=
no-issue=
article-no=
start-page=97
end-page=102
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130725
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Sex Difference in Dance Image of Junior High School Students
kn-title=中学生のダンスに対するイメージ―男女差の検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=SakoHaruko
en-aut-sei=Sako
en-aut-mei=Haruko
kn-aut-name=酒向治子
kn-aut-sei=酒向
kn-aut-mei=治子
aut-affil-num=1
ORCID=
en-aut-name=NagataMariko
en-aut-sei=Nagata
en-aut-mei=Mariko
kn-aut-name=永田麻里子
kn-aut-sei=永田
kn-aut-mei=麻里子
aut-affil-num=2
ORCID=
en-aut-name=IdeharaChinami
en-aut-sei=Idehara
en-aut-mei=Chinami
kn-aut-name=出原智波
kn-aut-sei=出原
kn-aut-mei=智波
aut-affil-num=3
ORCID=
en-aut-name=MiyamotoOtome
en-aut-sei=Miyamoto
en-aut-mei=Otome
kn-aut-name=宮本乙女
kn-aut-sei=宮本
kn-aut-mei=乙女
aut-affil-num=4
ORCID=
en-aut-name=IzakiYayoi
en-aut-sei=Izaki
en-aut-mei=Yayoi
kn-aut-name=猪崎弥生
kn-aut-sei=猪崎
kn-aut-mei=弥生
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=
affil-num=2
en-affil=
kn-affil=
affil-num=3
en-affil=
kn-affil=
affil-num=4
en-affil=
kn-affil=
affil-num=5
en-affil=
kn-affil=
en-keyword=ダンス
kn-keyword=ダンス
en-keyword=ジェンダー・イメージ
kn-keyword=ジェンダー・イメージ
en-keyword=ジェンダー・バイアス
kn-keyword=ジェンダー・バイアス
END
start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=2
article-no=
start-page=139
end-page=143
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of strangulated ileus caused by internal hernia through a defect in the broad ligament of the uterus
kn-title=子宮広間膜裂孔ヘルニアによる絞扼性イレウスの１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 41-year-old woman was admitted to our hospital because of lower abdominal pain. She had no history of laparotomy. An abdominal CT scan at the time of admission indicated closed-loop intestinal obstruction of the small intestine within the pelvis and deviation of the uterus to the right. We diagnosed this as a strangulated internal hernia and decided to conduct an emergency operation. The ileum had herniated through a defect in the broad ligament of the uterus. The strangulated intestinal loop, which was about 25cm long, was released, and the defect of the broad ligament was closed. The postoperative course was uneventful. The differential diagnosis of intestinal obstruction should include internal hernia, especially in the absence of a previous laparotomy. An abdominal CT scan is quite useful for the preoperative and prompt diagnosis of internal hernia through a defect in the broad ligament of the uterus.
en-copyright=
kn-copyright=
en-aut-name=HaisaMinoru
en-aut-sei=Haisa
en-aut-mei=Minoru
kn-aut-name=羽井佐実
kn-aut-sei=羽井佐
kn-aut-mei=実
aut-affil-num=1
ORCID=
en-aut-name=SakaiRyo
en-aut-sei=Sakai
en-aut-mei=Ryo
kn-aut-name=酒井亮
kn-aut-sei=酒井
kn-aut-mei=亮
aut-affil-num=2
ORCID=
en-aut-name=KuriharaEisuke
en-aut-sei=Kurihara
en-aut-mei=Eisuke
kn-aut-name=栗原英祐
kn-aut-sei=栗原
kn-aut-mei=英祐
aut-affil-num=3
ORCID=
en-aut-name=TeramotoAtsushi
en-aut-sei=Teramoto
en-aut-mei=Atsushi
kn-aut-name=寺本淳
kn-aut-sei=寺本
kn-aut-mei=淳
aut-affil-num=4
ORCID=
en-aut-name=ShougaKazuhiko
en-aut-sei=Shouga
en-aut-mei=Kazuhiko
kn-aut-name=庄賀一彦
kn-aut-sei=庄賀
kn-aut-mei=一彦
aut-affil-num=5
ORCID=
en-aut-name=MitsuokaShintarou
en-aut-sei=Mitsuoka
en-aut-mei=Shintarou
kn-aut-name=光岡晋太郎
kn-aut-sei=光岡
kn-aut-mei=晋太郎
aut-affil-num=6
ORCID=
en-aut-name=NishimuraMamoru
en-aut-sei=Nishimura
en-aut-mei=Mamoru
kn-aut-name=西村守
kn-aut-sei=西村
kn-aut-mei=守
aut-affil-num=7
ORCID=
en-aut-name=SatouYuuki
en-aut-sei=Satou
en-aut-mei=Yuuki
kn-aut-name=佐藤雄紀
kn-aut-sei=佐藤
kn-aut-mei=雄紀
aut-affil-num=8
ORCID=
en-aut-name=NanbaJiro
en-aut-sei=Nanba
en-aut-mei=Jiro
kn-aut-name=難波次郎
kn-aut-sei=難波
kn-aut-mei=次郎
aut-affil-num=9
ORCID=
affil-num=1
en-affil=
kn-affil=岡山市立市民病院 消化器外科
affil-num=2
en-affil=
kn-affil=岡山市立市民病院 消化器外科
affil-num=3
en-affil=
kn-affil=岡山市立市民病院 消化器外科
affil-num=4
en-affil=
kn-affil=岡山市立市民病院 消化器外科
affil-num=5
en-affil=
kn-affil=岡山市立市民病院 消化器外科
affil-num=6
en-affil=
kn-affil=岡山市立市民病院 消化器外科
affil-num=7
en-affil=
kn-affil=岡山市立市民病院 消化器内科
affil-num=8
en-affil=
kn-affil=岡山市立市民病院 消化器内科
affil-num=9
en-affil=
kn-affil=岡山市立市民病院 消化器内科
en-keyword=子宮広間膜裂孔（broad ligament）
kn-keyword=子宮広間膜裂孔（broad ligament）
en-keyword=内ヘルニア（internal hernia）
kn-keyword=内ヘルニア（internal hernia）
en-keyword=絞扼性イレウス（strangulated ileus）
kn-keyword=絞扼性イレウス（strangulated ileus）
en-keyword=MDCT（multi-detector CT）
kn-keyword=MDCT（multi-detector CT）
END
start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=2
article-no=
start-page=119
end-page=127
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The treatment strategy for clinical stage III non-small cell lung cancer
kn-title=臨床病期Ⅲ期肺非小細胞癌に対する治療戦略
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=木浦勝行
kn-aut-sei=木浦
kn-aut-mei=勝行
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学病院 呼吸器・アレルギー内科
en-keyword=concomitant chemoradiotherapy
kn-keyword=concomitant chemoradiotherapy
en-keyword=third generation
kn-keyword=third generation
en-keyword=surgery
kn-keyword=surgery
END
start-ver=1.4
cd-journal=joma
no-vol=152
cd-vols=
no-issue=
article-no=
start-page=45
end-page=49
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Gender Bias in Dance of Teachers and Junior High School's Students
kn-title=教員と中学生のダンスに対するジェンダー・バイアス
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=SakoHaruko
en-aut-sei=Sako
en-aut-mei=Haruko
kn-aut-name=酒向治子
kn-aut-sei=酒向
kn-aut-mei=治子
aut-affil-num=1
ORCID=
en-aut-name=NagataMariko
en-aut-sei=Nagata
en-aut-mei=Mariko
kn-aut-name=永田麻里子
kn-aut-sei=永田
kn-aut-mei=麻里子
aut-affil-num=2
ORCID=
en-aut-name=IdeharaChinami
en-aut-sei=Idehara
en-aut-mei=Chinami
kn-aut-name=出原智波
kn-aut-sei=出原
kn-aut-mei=智波
aut-affil-num=3
ORCID=
en-aut-name=SunamiJunko
en-aut-sei=Sunami
en-aut-mei=Junko
kn-aut-name=角南順子
kn-aut-sei=角南
kn-aut-mei=順子
aut-affil-num=4
ORCID=
en-aut-name=IzakiYayoi
en-aut-sei=Izaki
en-aut-mei=Yayoi
kn-aut-name=猪崎弥生
kn-aut-sei=猪崎
kn-aut-mei=弥生
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科生活・健康スポーツ学系保健体育講座
affil-num=2
en-affil=
kn-affil=お茶の水女子大学
affil-num=3
en-affil=
kn-affil=岡山市立操山中学校
affil-num=4
en-affil=
kn-affil=岡山市立操山中学校
affil-num=5
en-affil=
kn-affil=お茶の水女子大学
en-keyword=ダンス
kn-keyword=ダンス
en-keyword=ジェンダー・イメージ
kn-keyword=ジェンダー・イメージ
en-keyword=ジェンダー・バイアス
kn-keyword=ジェンダー・バイアス
END
start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=3
article-no=
start-page=249
end-page=252
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121203
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Current status of transplantation for diabetes mellitus
kn-title=糖尿病における移植療法の現状
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NoguchiHirofumi
en-aut-sei=Noguchi
en-aut-mei=Hirofumi
kn-aut-name=野口洋文
kn-aut-sei=野口
kn-aut-mei=洋文
aut-affil-num=1
ORCID=
en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=2
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器外科学
affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器外科学
en-keyword=膵臓移植
kn-keyword=膵臓移植
en-keyword=膵島移植
kn-keyword=膵島移植
en-keyword=インスリン離脱率
kn-keyword=インスリン離脱率
en-keyword=生存率
kn-keyword=生存率
en-keyword=エドモントンプロトコール
kn-keyword=エドモントンプロトコール
END
start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=2
article-no=
start-page=354
end-page=359
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Scanning and non-scanning surface plasmon microscopy to observe cell adhesion sites
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We observe adhesion sites of a cell on a substrate with high resolution. Since this observation requires interfacial measurements between the cell and the substrate, we employ scanning localized surface plasmon microscopy. We experimentally show that focal adhesion sites of a mouse muscle cell can be observed without fluorescent labeling. We also show that a non-scanning surface plasmon microscope combined with the scanning localized surface plasmon microscope contributes to observing an entire cell adhesion site and identify regions of interest.
en-copyright=
kn-copyright=
en-aut-name=WatanabeKoyo
en-aut-sei=Watanabe
en-aut-mei=Koyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=MatsuuraKoji
en-aut-sei=Matsuura
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=KawataFukukazu
en-aut-sei=Kawata
en-aut-mei=Fukukazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NagataKotaro
en-aut-sei=Nagata
en-aut-mei=Kotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=NingJun
en-aut-sei=Ning
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=KanoHiroshi
en-aut-sei=Kano
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Division of Information and Electronic Engineering, Graduate School of Engineering, Muroran Institute of Technology
affil-num=4
en-affil=
kn-affil=Division of Information and Electronic Engineering, Graduate School of Engineering, Muroran Institute of Technology
affil-num=5
en-affil=
kn-affil=Division of Engineering for Composite Functions, Graduate School of Engineering, Muroran Institute of Technology
affil-num=6
en-affil=
kn-affil=Division of Engineering for Composite Functions, Graduate School of Engineering, Muroran Institute of Technology
END
start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=129
end-page=136
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Antibacterial efficacy of photocatalytic reaction on titanium dioxide-coated ceramic air filters
kn-title=酸化チタン担持セラミックフィルターの光触媒反応による抗菌効果の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Titanium dioxide (TiO2) photocatalysis generates reactive oxygen species such as ・OH and ・O2-, which can effectively eliminate organic compounds. In the present study, we evaluated the antibacterial and antifungal effects of TiO2-coated ceramic air filters in both laboratory and hospital settings. Photocatalysis with the TiO2-coated ceramic filter effectively inactivated all 4 pathogenic organisms tested. Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. After the photocatalysis reaction for 4 h under UV-A (365nm, 250μW/㎠) irradiation, the percentage reductions of the number of E. coli, P. aeruginosa, S. aureus, C. albicans cells were 99.9%, 98.9%, 97.7% and 99.9%, respectively, indicating that Gram-negative bacteria are more susceptible to such photocatalysis than Gram-positive bacteria. Scanning electron microscopic analysis showed damage to the cytoplasmic membrane and cell wall by photocatalysis : consistent with above observations, the morphological change of Gram-negative E. coli was greater than that of Gram-positive S. aureus. Further, an air cleaner equipped with a TiO2-coated ceramic filter significantly decreased the number of bacteria floating in hospitals. These results indicate that air cleaners with TiO2-coated ceramic filters could be useful in reducing the incidence of nosocomial infections.
en-copyright=
kn-copyright=
en-aut-name=NakaoMiyuki
en-aut-sei=Nakao
en-aut-mei=Miyuki
kn-aut-name=中尾美幸
kn-aut-sei=中尾
kn-aut-mei=美幸
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病原細菌学
en-keyword=光触媒（photocatalysis）
kn-keyword=光触媒（photocatalysis）
en-keyword=酸化チタン担持セラミックフィルター（TiO2-coated ceramic air filters）
kn-keyword=酸化チタン担持セラミックフィルター（TiO2-coated ceramic air filters）
en-keyword=抗菌効果（antimicrobial effect）
kn-keyword=抗菌効果（antimicrobial effect）
en-keyword=院内感染（nosocomial infection）
kn-keyword=院内感染（nosocomial infection）
en-keyword=空気清浄機（air cleaner）
kn-keyword=空気清浄機（air cleaner）
END
start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=3
article-no=
start-page=19
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19911216
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Invalidity of the Simultaneous Confidence Interval Corresponding to the Step-down Procedure under the Multiple Comparison
kn-title=多重比較における下降手順に対応する同時信頼区間の非妥当性についての考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=永田靖
kn-aut-sei=永田
kn-aut-mei=靖
aut-affil-num=1
ORCID=
en-aut-name=MatsudaShin-ichi
en-aut-sei=Matsuda
en-aut-mei=Shin-ichi
kn-aut-name=松田眞一
kn-aut-sei=松田
kn-aut-mei=眞一
aut-affil-num=2
ORCID=
affil-num=1
en-affil=
kn-affil=
affil-num=2
en-affil=
kn-affil=南山大学経営学部情報管理学科
END
start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=4
article-no=
start-page=301
end-page=314
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=19940310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Approximation Formulas for the Lower Confidence Limits of Process Capability Indices
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=永田靖
kn-aut-sei=永田
kn-aut-mei=靖
aut-affil-num=1
ORCID=
en-aut-name=NagahataHidekazu
en-aut-sei=Nagahata
en-aut-mei=Hidekazu
kn-aut-name=長畑秀和
kn-aut-sei=長畑
kn-aut-mei=秀和
aut-affil-num=2
ORCID=
affil-num=1
en-affil=
kn-affil=Faculty of Economics, Okayama University
affil-num=2
en-affil=
kn-affil=Faculty of Education, Okayama University
END
start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=3-4
article-no=
start-page=325
end-page=339
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19950310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=POINT ESTIMATION OF THE PROCESS CAPABILITY INDEX C(pk)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper point estimation of the process capability index C(pk) is considered. In order to improve on the natural estimator, a simple alternative estimator is proposed and its mean square error is evaluated numerically.
en-copyright=
kn-copyright=
en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=永田靖
kn-aut-sei=永田
kn-aut-mei=靖
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=Faculty of Economics, Okayama University
END
start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=4
article-no=
start-page=293
end-page=316
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Stein Type Confidence Interval of the Disturbance Variance in a Linear Regression Model
kn-title=回帰分析における誤差分散のスタイン型改良信頼区間の諸性質
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper the interval estimation of the disturbance variance in a linear regression model is discussed from several view points. Firstly, a brief summary ofthe Stein type point estimation theory and the Stein type interval estimation theory is given. Then, the relationship between the improvement on the point estimation and the improvement on the interval estimation is discussed. It is shown that substituting the Stein type estimator for the usual estimator in the confidence interval leads to the improvement on the interval estimation. Secondly, the Neyman accuracy of the Stein type confidence interval
is considered. The Neyman accuracy is a measure related to the unbiasedness of a confidence interval. It is shown that the Stein type confidence interval is not unbiased. Thirdly, the Wolfowitz accuracy of the Stein type confidence interval is considered. The Wolfowitz accuracy is related to the closeness of the endpoints to. the true parameter. The sufficient condition for the Stein type confidence interval to improve on the usual confidence interval is derived. Finally, the Stein type confidence interval is discussed under the multivariate Student-t distribution. It is shown that so far as the coverage probability and the multivariate Student-t distributions are concerned, the Stein type confidence interval is not robust against nonnormality, but that the superiority over the usual confidence interval still holds against nonnormality. Furthermore, for the case when it is known that error terms have a multivariate Student-t distribution, a Stein type confidence interval which improves on the usual confidence interval is presented.
en-copyright=
kn-copyright=
en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=永田靖
kn-aut-sei=永田
kn-aut-mei=靖
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=
END
start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=3
article-no=
start-page=271
end-page=280
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=19990310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Optimality of the Stein Type Confidence Interval of Variance
kn-title=誤差分散のスタイン型改良信頼区間の最適性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper the optimality of the Stein type confidence interval of the disturbance variance among the class of pre-test confidence interval after the pre-test for a linear hypothesis on coefficients is considered. The Stein type confidence interval is a member in the class with a critical value, say c. It is known that the Stein type confidence interval is the best in the subclass which consists of the pre-test confidence intervals with a smaller critical value than c. It is shown that an extension of the optimality to a larger class is not possible.
en-copyright=
kn-copyright=
en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=永田靖
kn-aut-sei=永田
kn-aut-mei=靖
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=
END
start-ver=1.4
cd-journal=joma
no-vol=32
cd-vols=
no-issue=1
article-no=
start-page=57
end-page=68
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20000610
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Assimilation Effect in Judging the Grammaticality of Sentences Violating the Subjacency Condition: A Further Exploration
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study explored an assimilation effect in judging the grammaticality of sentences violating the subjacency condition. The target sentences included either a noun phrase (NP-extracted) or an
adverbial phrase (AP-extracted), each extracted from a subordinate clause and placed in front of the sentences. Anchor sentences had a surface structure similar to the AP-extracted targets such that a preposed adverbial phrase could be associated both with the subordinate
and the matrix verb. Twenty-eight speakers classified as field-dependent judged the two types oftarget sentences given together with anchors or no anchors. The assimilation as well as the contrast effect was found, albeit
to a slight degree. The level of judged grammaticality of the anchors rather than surface structure similarity appeared to be more influential in producing the anchoring effects in the judgments of the grammaticality of sentences.
en-copyright=
kn-copyright=
en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=Faculty of Economics, Okayama University
END
start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=2
article-no=
start-page=25
end-page=34
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20010910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Japanese speakers’ judgments of grammaticality of Japanese and English bitransitive sentences with a differing number of arguments : A comparison between speakers exposed to Chomsky’s generative grammar and those not
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigates the judgments of grammaticality of Japanese and English bitransitive sentences with a differing number of arguments. Japanese speakers exposed to Chomsky’s generative grammar (n = 30) and those not exposed (n = 28) were compared. This exposure was expected to facilitate a sentence− oriented
judgment strategy that would direct speakers towards decreasing the grammaticality of the Japanese sentences lacking one or more arguments. Findings showed no effect in the judgments of Japanese sentences. However, in the judgments of the English sentences speakers exposed to generative grammar approximated to those made by
native speakers of English. It was suggested that the exposure to generative grammar facilitated the sentence−oriented strategy in the judgments of English sentences, but it was not so effective as to weaken a discourse−oriented strategy used by Japanese speakers when they judged Japanese sentences.
en-copyright=
kn-copyright=
en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=
END
start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=1
article-no=
start-page=37
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=199901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Nagata Criterion for Serre's (Rn) and (Sn)-Conditions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=TakahashiRyo
en-aut-sei=Takahashi
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=Okayama University
END
start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=3
article-no=
start-page=209
end-page=214
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=197606
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An extremely basic monoclonal IgG in an aged apoplectic patient with prolonged bacterial infection
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A case with prolonged bacterial infection accompanied by an abnormal serum protein which migrated in the post-gamma region on electrophoresis is presented. The abnormal protein was identified as IgG with gamma-type light chain moiety. The patient suffered from prolonged pneumonia and cholecystitis, Bone marrow aspiration and skeletal x-rays did not indicate multiple myeloma.
en-copyright=
kn-copyright=
en-aut-name=ArimaTerukatsu
en-aut-sei=Arima
en-aut-mei=Terukatsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=TsuboiShuhei
en-aut-sei=Tsuboi
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NagataKowichi
en-aut-sei=Nagata
en-aut-mei=Kowichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=GyotenYozo
en-aut-sei=Gyoten
en-aut-mei=Yozo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=TanigawaTakashi
en-aut-sei=Tanigawa
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=ImaiMasanobu
en-aut-sei=Imai
en-aut-mei=Masanobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=KitaShowichi
en-aut-sei=Kita
en-aut-mei=Showichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
affil-num=1
en-affil=
kn-affil=Okayama University
affil-num=2
en-affil=
kn-affil=Mitoyo General Hospital
affil-num=3
en-affil=
kn-affil=Mitoyo General Hospital
affil-num=4
en-affil=
kn-affil=Mitoyo General Hospital
affil-num=5
en-affil=
kn-affil=Mitoyo General Hospital
affil-num=6
en-affil=
kn-affil=Mitoyo General Hospital
affil-num=7
en-affil=
kn-affil=Okayama University
END
start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=5
article-no=
start-page=271
end-page=278
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=199810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Nursing practitioners' perception of inpatients' anxiety, self-esteem, purpose-in-life and health locus of control.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Nursing practitioners' perception of inpatients' anxiety, self-esteem, purpose-in-life and health locus of control.
en-copyright=
kn-copyright=
en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=OhtaTakeo
en-aut-sei=Ohta
en-aut-mei=Takeo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=AoyamaHideyasu
en-aut-sei=Aoyama
en-aut-mei=Hideyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
affil-num=1
en-affil=
kn-affil=Okayama University
affil-num=2
en-affil=
kn-affil=Okayama University
affil-num=3
en-affil=
kn-affil=Okayama Univeristy
en-keyword=inpatient's mental health
kn-keyword=inpatient's mental health
en-keyword=anxiety
kn-keyword=anxiety
en-keyword=self-es-teem
kn-keyword=self-es-teem
en-keyword=purpose-in-life
kn-keyword=purpose-in-life
en-keyword=health locus of control
kn-keyword=health locus of control
END
start-ver=1.4
cd-journal=joma
no-vol=38
cd-vols=
no-issue=5
article-no=
start-page=461
end-page=469
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=198410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Quantitative analysis of the production of heat-labile enterotoxin by enterotoxigenic Escherichia coli.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A modified method of passive immune hemolysis (PIH) was applied to the quantitative assay of heat-labile enterotoxin (LT) produced by enterotoxigenic Escherichia coli. The method enabled the measurement of 0.2 to 1.2 ng LT. The production of LT by enterotoxigenic E. coli under various conditions was analyzed using the modified method. LT production was intense during the logarithmic growth phase and decreased during the stationary growth phase. Lincomycin (50 to 100 micrograms/ml) affected cell growth slightly, but enhanced production of LT until the late-stationary growth phase. About 90% of the LT produced was retained in the cell, and the rest was excreted into the culture medium. The initial pH of the culture medium affected LT production. Alkaline pH enhanced LT production, though growth was depressed. Aeration enhanced both growth and LT production.
en-copyright=
kn-copyright=
en-aut-name=MinamiJunzabro
en-aut-sei=Minami
en-aut-mei=Junzabro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=OkabeAkinobu
en-aut-sei=Okabe
en-aut-mei=Akinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NagataAkihide
en-aut-sei=Nagata
en-aut-mei=Akihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=HayashiHideo
en-aut-sei=Hayashi
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
affil-num=1
en-affil=
kn-affil=Kagawa Medical School
affil-num=2
en-affil=
kn-affil=Kagawa Medical School
affil-num=3
en-affil=
kn-affil=Okayama Univeristy
affil-num=4
en-affil=
kn-affil=Kagawa Medical School
en-keyword=heat-labile enterotoxin
kn-keyword=heat-labile enterotoxin
en-keyword=E
kn-keyword=E
en-keyword=coli
kn-keyword=coli
en-keyword=passive immune hemolysis
kn-keyword=passive immune hemolysis
END
start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=284
end-page=289
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Extended ISM for Globally Multimodal Function Optimization by Genetic Algorithms
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=When attempting to optimize a function where exists several big-valley structures, conventional GAs often fail to find the global optimum. Innately Split Model (ISM) is a framework of GAs, which is designed to avoid this phenomenon called UV-Phenomenon. However, ISM doesn't care about previously-searched areas by the past populations. Thus, it is possible that populations of ISM waste evaluation cost for redundant searches reaching previously-found optima. In this paper, we introduce Extended ISM (EISM) that uses search information of past populations as trap to suppress overlapping searches. To show performance of EISM, we apply it to some test functions, and analyze the behavior.
en-copyright=
kn-copyright=
en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KaratsuNaoya
kn-aut-sei=Karatsu
kn-aut-mei=Naoya
aut-affil-num=1
ORCID=
en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NagataYuichi
kn-aut-sei=Nagata
kn-aut-mei=Yuichi
aut-affil-num=2
ORCID=
en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OnoIsao
kn-aut-sei=Ono
kn-aut-mei=Isao
aut-affil-num=3
ORCID=
en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KobayashiShigenobu
kn-aut-sei=Kobayashi
kn-aut-mei=Shigenobu
aut-affil-num=4
ORCID=
affil-num=1
en-affil=
kn-affil=Tokyo Institute of Technology
affil-num=2
en-affil=
kn-affil=Tokyo Institute of Technology
affil-num=3
en-affil=
kn-affil=Tokyo Institute of Technology
affil-num=4
en-affil=
kn-affil=Tokyo Institute of Technology
END
start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=
article-no=
start-page=31
end-page=55
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第4章 歴史学研究の一分析要因として「気候」を取り込むことは可能か？ ―ヨーロッパ近世＜小氷期Little Ice Age＞の場合―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NagataRiyouichi
en-aut-sei=Nagata
en-aut-mei=Riyouichi
kn-aut-name=永田諒一
kn-aut-sei=永田
kn-aut-mei=諒一
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学
END
start-ver=1.4
cd-journal=joma
no-vol=80
cd-vols=
no-issue=1-2
article-no=
start-page=135
end-page=141
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1968
dt-pub=19680228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Report of a Case of Nasopharyngeal Tumor
kn-title=鼻咽腔原発悪性腫瘍の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper is to report a case of naeopharyngeal tumor. The patient was a 57 years old man admitted to this hospital with chief complaints of impaired hearing and headache. The diagnosis had not been made until the biopsy of the enlarged lymphnode in the right neck was performed and histologically examined. The patient died in spits of radiation therapy with (60)Co over the neck. Postmortem examination revealed undifferentiated cell carcinoma in sphenoethomoidal sinus and its metastasis to the liver, lumbar vertebrae, and lymphnodes of various area. Studies on 41 cases of nasopharyngeal tumor experienced in the department of Otorhinopharyngol-aryngology of this University in recent 10 years (1957-1966) showed that a large number of the patient as much as 24% of the cases, first visited the clinic of internal medicine of examination of enlarged lymphnodes in the neck or headache.
en-copyright=
kn-copyright=
en-aut-name=MiyazakiTakeshi
en-aut-sei=Miyazaki
en-aut-mei=Takeshi
kn-aut-name=宮崎健史
kn-aut-sei=宮崎
kn-aut-mei=健史
aut-affil-num=1
ORCID=
en-aut-name=NagataKoichi
en-aut-sei=Nagata
en-aut-mei=Koichi
kn-aut-name=永田耕一
kn-aut-sei=永田
kn-aut-mei=耕一
aut-affil-num=2
ORCID=
en-aut-name=OkutomiZenkichi
en-aut-sei=Okutomi
en-aut-mei=Zenkichi
kn-aut-name=奥富善吉
kn-aut-sei=奥富
kn-aut-mei=善吉
aut-affil-num=3
ORCID=
en-aut-name=YumotoYasuhiro
en-aut-sei=Yumoto
en-aut-mei=Yasuhiro
kn-aut-name=湯本泰弘
kn-aut-sei=湯本
kn-aut-mei=泰弘
aut-affil-num=4
ORCID=
en-aut-name=OtsukiHiroshi
en-aut-sei=Otsuki
en-aut-mei=Hiroshi
kn-aut-name=大朏祐治
kn-aut-sei=大朏
kn-aut-mei=祐治
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室
affil-num=3
en-affil=
kn-affil=岡山大学医学部第一内科教室
affil-num=4
en-affil=
kn-affil=岡山大学医学部第一内科教室
affil-num=5
en-affil=
kn-affil=岡山大学医学部第一内科教室
END
start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1309
end-page=1317
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of the standard total coli-form MPN test for the biological examination of water pollution
kn-title=大腸菌群測定法の水質汚染指標性の検討
en-subtitle=
kn-subtitle=
en-abstract=The standard total coli-form MPN test is widely used as a biological indicator of water pollution. But our applications of the test to various field works resulted in much higher cell numbers than be expected. The reason can be thought to be that bacteria belonging to coliform group do not always derived from human and animal feces. In order to examine this possibility, the authors carried out the isolation and identification of bacteria which were detected by this method from various kinds of specimens. The result indicated that the bacteria designated as coli-form group included not only human- and animal-derived bacteria but also bacterial species which apparently derived from plants, soil or water, e.g. Erwinia, Aeromonas, Serratia, Citrobacter and so forth. Therefore, a method is demanded by which one can estimate quantitatively only bacteria associated with human and animal feces.
kn-abstract=水質検査には化学的検査項目以外に細菌学的検査項目が併行して行われていることは周知の事実である(1,2)).そして我国における現在の水質検査法(3))では大腸菌群測定法が広く用いられている.すなわち上水試験法(4))および工業用水(JIS)(1))ではLB培地-BGLB培地法(LB-BGLB法と略す),下水試験法ではLB培地法(LB法と略す),食品衛生法および公共用水ではBGLB培地法(BGLB法と略す)を行うとされており,これらはいずれも最確数(MPN)を求める方法である.他方乳製品および工場排水(JIS)(2))ではデスオキシコレート培地(DOC法と略す)を用いての集落数を求める方法も行われている.これら諸種の方法のうち,上水試験法および工業用水(JIS)(1))に適用されている.LB-BGLB法で算定される大腸菌群の検討を試みた.LB-BGLB法で算定される大腸菌群とは"乳糖を分解して酸とガスを産生する好気性または通性嫌気性のグラム陰性無芽胞桿菌である”.と定義され,この条件を満す種属はEscherichia,Klebsiella,Enterobacter,Aeromonas,Erwinia,SerratiaおよびCitrobacter等が包含されている.しかしこれらの種属全てが人畜糞便由来のものではなく,水,植物または土壌に由来する種属も含まれていると言うことである.元来,水質検査における汚染指標菌とは人畜糞便由来の菌を検索することを目的としているのであるから,大腸菌群測定結果をそのまま適用して汚染状況や汚染源の判定を行うと誤りを生ずることになりかねない.我々は過去数年間に亘って児島湾(5)),児島湖(6))を初めとして県下河川(7,8))での汚染調査を行って来たが,その結果のなかで化学検査や現況に照して不当と思われるような高値の大腸菌群数を算定することがしばしばあった.そこで各種調査点での現行の大腸菌群測定で得られる測定結果の検討を,本測定法で算定される大腸菌群の種属分類を行うことにより,糞便汚染の指標性の良否について検討することとした.
en-copyright=
kn-copyright=
en-aut-name=AkatsukaKazuya
en-aut-sei=Akatsuka
en-aut-mei=Kazuya
kn-aut-name=赤塚和也
kn-aut-sei=赤塚
kn-aut-mei=和也
aut-affil-num=1
ORCID=
en-aut-name=MoriYasumi
en-aut-sei=Mori
en-aut-mei=Yasumi
kn-aut-name=森康己
kn-aut-sei=森
kn-aut-mei=康己
aut-affil-num=2
ORCID=
en-aut-name=KoujimaIzumi
en-aut-sei=Koujima
en-aut-mei=Izumi
kn-aut-name=国府島泉
kn-aut-sei=国府島
kn-aut-mei=泉
aut-affil-num=3
ORCID=
en-aut-name=HiraiYoshikazu
en-aut-sei=Hirai
en-aut-mei=Yoshikazu
kn-aut-name=平井義一
kn-aut-sei=平井
kn-aut-mei=義一
aut-affil-num=4
ORCID=
en-aut-name=HamadaHiroshi
en-aut-sei=Hamada
en-aut-mei=Hiroshi
kn-aut-name=浜田博司
kn-aut-sei=浜田
kn-aut-mei=博司
aut-affil-num=5
ORCID=
en-aut-name=AbeMasufumi
en-aut-sei=Abe
en-aut-mei=Masufumi
kn-aut-name=安部益文
kn-aut-sei=安部
kn-aut-mei=益文
aut-affil-num=6
ORCID=
en-aut-name=AbeShigenobu
en-aut-sei=Abe
en-aut-mei=Shigenobu
kn-aut-name=安部重信
kn-aut-sei=安部
kn-aut-mei=重信
aut-affil-num=7
ORCID=
en-aut-name=KukidaShozo
en-aut-sei=Kukida
en-aut-mei=Shozo
kn-aut-name=茎田祥三
kn-aut-sei=茎田
kn-aut-mei=祥三
aut-affil-num=8
ORCID=
en-aut-name=NagataAkihide
en-aut-sei=Nagata
en-aut-mei=Akihide
kn-aut-name=永田哲英
kn-aut-sei=永田
kn-aut-mei=哲英
aut-affil-num=9
ORCID=
en-aut-name=FujiwaraKiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Kiyoshi
kn-aut-name=藤原清
kn-aut-sei=藤原
kn-aut-mei=清
aut-affil-num=10
ORCID=
en-aut-name=HayashiHideo
en-aut-sei=Hayashi
en-aut-mei=Hideo
kn-aut-name=林英生
kn-aut-sei=林
kn-aut-mei=英生
aut-affil-num=11
ORCID=
en-aut-name=KanemasaYasuhiro
en-aut-sei=Kanemasa
en-aut-mei=Yasuhiro
kn-aut-name=金政泰弘
kn-aut-sei=金政
kn-aut-mei=泰弘
aut-affil-num=12
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部ウイルス学教室
affil-num=2
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=3
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=4
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=5
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=6
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=7
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=8
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=9
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=10
en-affil=
kn-affil=岡山大学医学部附属臨床検査技師学校
affil-num=11
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=12
en-affil=
kn-affil=岡山大学医学部細菌学教室
END
start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=3
article-no=
start-page=215
end-page=218
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Extremely high-quality radiation therapy
kn-title=高精度放射線治療
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=KatsuiKuniaki
en-aut-sei=Katsui
en-aut-mei=Kuniaki
kn-aut-name=勝井邦彰
kn-aut-sei=勝井
kn-aut-mei=邦彰
aut-affil-num=1
ORCID=
en-aut-name=TakemotoMitsuhiro
en-aut-sei=Takemoto
en-aut-mei=Mitsuhiro
kn-aut-name=武本充広
kn-aut-sei=武本
kn-aut-mei=充広
aut-affil-num=2
ORCID=
en-aut-name=KanazawaSusumu
en-aut-sei=Kanazawa
en-aut-mei=Susumu
kn-aut-name=金澤右
kn-aut-sei=金澤
kn-aut-mei=右
aut-affil-num=3
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学病院 放射線科
affil-num=2
en-affil=
kn-affil=岡山大学病院 放射線科
affil-num=3
en-affil=
kn-affil=岡山大学病院 放射線科
END
start-ver=1.4
cd-journal=joma
no-vol=96
cd-vols=
no-issue=7-8
article-no=
start-page=767
end-page=777
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19840830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of heat-labile enterotoxin from enterotoxigenic Escherichia coli on the structure of rabbit intestinal epitherial cell and the brush border
kn-title=毒素原性大腸菌が産生する易熱性エンテロトキシンの小腸絨毛上皮細胞膜に対する作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Heat-labile enterotoxin produced by enterotoxigenic E. coli affected the structure of epitherial cell of rabbit intestine. The toxin bound to the microbilli of the cell and caused "puffing" of the microvillous membrane when it was examined under phasecontrast microscopy. The same change occured by the isolated brush border membrane if it was reacted with the enterotoxin in the presence of ATP. Electronmicroscopic observation disclosed that the bundle fibrous structure of the brush border was deformed to random structure and that some parts of the fibrous bundle detached from microvillous membrane. Since the enterotoxin bound to microvilli, it was suggested that cytoskelton including actin and myosin system of the cell could be affected through cAMP of which synthesis was activated at the microvilli membrane by the enterotoxin.
en-copyright=
kn-copyright=
en-aut-name=NagataAkihide
en-aut-sei=Nagata
en-aut-mei=Akihide
kn-aut-name=永田哲英
kn-aut-sei=永田
kn-aut-mei=哲英
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部細菌学教室
en-keyword=毒素原性大腸菌
kn-keyword=毒素原性大腸菌
en-keyword=エンテロトキシン
kn-keyword=エンテロトキシン
en-keyword=小腸絨毛上皮細胞
kn-keyword=小腸絨毛上皮細胞
en-keyword=刷子縁
kn-keyword=刷子縁
en-keyword=サイトスケルトン
kn-keyword=サイトスケルトン
END
start-ver=1.4
cd-journal=joma
no-vol=95
cd-vols=
no-issue=1-2
article-no=
start-page=35
end-page=40
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19830228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Identification of sphingoglycolipids in a patient regarded as having Fabry's disease.
kn-title=ファブリー病を疑われる一症例の生化学的同定について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fabry's disease is one of the inherited diseases, in which sphingoglycolipids accumulate systemically in tissue as the result of defective α-galactosyl hydrolase. In this paper, we studied a 54 year-old female who had complaints of leg pain, palpebral edema and telangiectasis and in whom foam cells in renal biopsy as well as proteinuria in urinalysis were revealed. As an increase of sphingoglycolipids was discovered in her urinary sediment by biochemical analysis, this patient was shown to be suffering from Fabry's disease.
en-copyright=
kn-copyright=
en-aut-name=FujiiJunko
en-aut-sei=Fujii
en-aut-mei=Junko
kn-aut-name=藤井順子
kn-aut-sei=藤井
kn-aut-mei=順子
aut-affil-num=1
ORCID=
en-aut-name=KiguchiKenichiro
en-aut-sei=Kiguchi
en-aut-mei=Kenichiro
kn-aut-name=木口健一郎
kn-aut-sei=木口
kn-aut-mei=健一郎
aut-affil-num=2
ORCID=
en-aut-name=NagataAkihide
en-aut-sei=Nagata
en-aut-mei=Akihide
kn-aut-name=永田哲英
kn-aut-sei=永田
kn-aut-mei=哲英
aut-affil-num=3
ORCID=
en-aut-name=KariyamaReiko
en-aut-sei=Kariyama
en-aut-mei=Reiko
kn-aut-name=狩山玲子
kn-aut-sei=狩山
kn-aut-mei=玲子
aut-affil-num=4
ORCID=
en-aut-name=HiraiYoshikazu
en-aut-sei=Hirai
en-aut-mei=Yoshikazu
kn-aut-name=平井義一
kn-aut-sei=平井
kn-aut-mei=義一
aut-affil-num=5
ORCID=
en-aut-name=KanemasaYasuhiro
en-aut-sei=Kanemasa
en-aut-mei=Yasuhiro
kn-aut-name=金政泰弘
kn-aut-sei=金政
kn-aut-mei=泰弘
aut-affil-num=6
ORCID=
en-aut-name=KobayashiJun
en-aut-sei=Kobayashi
en-aut-mei=Jun
kn-aut-name=小林純
kn-aut-sei=小林
kn-aut-mei=純
aut-affil-num=7
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=2
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=3
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=4
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=5
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=6
en-affil=
kn-affil=岡山大学医学部細菌学教室
affil-num=7
en-affil=
kn-affil=岡山協立病院
en-keyword=Fabry's disease
kn-keyword=Fabry's disease
en-keyword=Lipidosis
kn-keyword=Lipidosis
en-keyword=Hexosyl ceramide
kn-keyword=Hexosyl ceramide
en-keyword=Hereditary disease
kn-keyword=Hereditary disease
END
start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=2
article-no=
start-page=129
end-page=134
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Differences in interpersonal values for three cohorts of new nursing students
kn-title=看護学生における対人関係価値のコホートによる相違
en-subtitle=
kn-subtitle=
en-abstract=KG-SIV (Kikuchi-Gordon Survey of Interpersonal Values) was administered twice to three cohorts of new nursing students admitted to School of Health Sciences, Okayama University, respectively, in 1990, 1993, and 1996. For the first testing, they indicated the values that were important to them, while for the second they indicated those that were important to an ideal nurse they had in their mind. Analyses showed that perceived values of Support and Independence increased while those of Benevolence decreased with the admission years. They also showed a reduced level of aspiration for an ideal nurse, particularly in 1996. Findings were discussed as they
were related with a socialization process that nursing students would undertake in prospective nurse training.
kn-abstract=医療短大入学年(1990年,1993年,1996年)において異なるコホートをなす看護学生の対人関係価値を入学直後に自己像と理想のナース像についてKG-SIV(Kikuchi-Gordon Survey of Interpersonal Values)によって測定した｡その結果,自己像評定では入学年が進むにつれて｢支持｣や｢独立｣の価値を重視する傾向が増大するのに対し,｢博愛｣の価値は逆に重視されない傾向が見いだされた｡また,特に1996年では理想のナース像に対する要求水準が低くなることも明らかになった｡この結果を看護学生の社会化過程と関連づけて考察した｡
en-copyright=
kn-copyright=
en-aut-name=KatoKumiko
en-aut-sei=Kato
en-aut-mei=Kumiko
kn-aut-name=加藤久美子
kn-aut-sei=加藤
kn-aut-mei=久美子
aut-affil-num=1
ORCID=
en-aut-name=KondoMasuko
en-aut-sei=Kondo
en-aut-mei=Masuko
kn-aut-name=近藤益子
kn-aut-sei=近藤
kn-aut-mei=益子
aut-affil-num=2
ORCID=
en-aut-name=TadaMasako
en-aut-sei=Tada
en-aut-mei=Masako
kn-aut-name=多田政子
kn-aut-sei=多田
kn-aut-mei=政子
aut-affil-num=3
ORCID=
en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=永田博
kn-aut-sei=永田
kn-aut-mei=博
aut-affil-num=4
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医療技術短期大学部
affil-num=2
en-affil=
kn-affil=岡山大学医療技術短期大学部
affil-num=3
en-affil=
kn-affil=香川県健康民生部
affil-num=4
en-affil=
kn-affil=岡山大学医療技術短期大学部
en-keyword=対人関係価値 (interpersonal values)
kn-keyword=対人関係価値 (interpersonal values)
en-keyword=看護学生 (nursing students)
kn-keyword=看護学生 (nursing students)
en-keyword=コホート (cohorts)
kn-keyword=コホート (cohorts)
en-keyword=社会化 (socialization)
kn-keyword=社会化 (socialization)
END
start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=2
article-no=
start-page=85
end-page=90
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=CRTH2 plays an essential role in the pathophysiology of Cry j 1 -induced pollinosis in mice
kn-title=マウススギ花粉症モデルにおける CRTH2の役割
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=NomiyaRie
en-aut-sei=Nomiya
en-aut-mei=Rie
kn-aut-name=野宮理恵
kn-aut-sei=野宮
kn-aut-mei=理恵
aut-affil-num=1
ORCID=
en-aut-name=OkanoMitsuhiro
en-aut-sei=Okano
en-aut-mei=Mitsuhiro
kn-aut-name=岡野光博
kn-aut-sei=岡野
kn-aut-mei=光博
aut-affil-num=2
ORCID=
en-aut-name=FujiwaraTazuko
en-aut-sei=Fujiwara
en-aut-mei=Tazuko
kn-aut-name=藤原田鶴子
kn-aut-sei=藤原
kn-aut-mei=田鶴子
aut-affil-num=3
ORCID=
en-aut-name=NishizakiKazunori
en-aut-sei=Nishizaki
en-aut-mei=Kazunori
kn-aut-name=西﨑和則
kn-aut-sei=西﨑
kn-aut-mei=和則
aut-affil-num=4
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学
affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学
affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学
affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学
en-keyword=スギ花粉症
kn-keyword=スギ花粉症
en-keyword=モデルマウス
kn-keyword=モデルマウス
en-keyword=プロスタグランジンD(2)
kn-keyword=プロスタグランジンD(2)
en-keyword=CRTH(2)
kn-keyword=CRTH(2)
END
start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Spa therapy as pulmonary rehabilitation for chronic obstructive pulmonary disease
kn-title=慢性閉塞性肺疾患における呼吸リハビリテーションとしての温泉療法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 老年医学
en-keyword=慢性閉塞性肺疾患
kn-keyword=慢性閉塞性肺疾患
en-keyword=呼吸リハビリテーション
kn-keyword=呼吸リハビリテーション
en-keyword=温泉療法
kn-keyword=温泉療法
en-keyword=肺機能
kn-keyword=肺機能
en-keyword=高分解能CT
kn-keyword=高分解能CT
END
start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=73
end-page=94
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On climatology in Misasa spa (twenty-fifrh report)
kn-title=三朝温泉地の気候について(第25報）
en-subtitle=
kn-subtitle=
en-abstract=Climatological data ofthe last 12 months (2002. 1. 1.- 2002. 12. 31) obtained by the climate autorecording system at the Misasa Medical Branch in Misasa Spa, Tottori-ken, Japan are presented.
kn-abstract=我々は1956年以降,三朝温泉地の気候について観察を行っている｡今回は2002年1月1日から2002年12月末日までの1年間の気象観察資料を報
告する｡機器の故障により,欠落部分が多々あることをお断りしておく。
en-copyright=
kn-copyright=
en-aut-name=MatsubaraFumie
en-aut-sei=Matsubara
en-aut-mei=Fumie
kn-aut-name=松原扶美恵
kn-aut-sei=松原
kn-aut-mei=扶美恵
aut-affil-num=1
ORCID=
en-aut-name=InoueTaeko
en-aut-sei=Inoue
en-aut-mei=Taeko
kn-aut-name=井上妙子
kn-aut-sei=井上
kn-aut-mei=妙子
aut-affil-num=2
ORCID=
en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=光延彰子
kn-aut-sei=光延
kn-aut-mei=彰子
aut-affil-num=3
ORCID=
en-aut-name=NagataTakuya
en-aut-sei=Nagata
en-aut-mei=Takuya
kn-aut-name=永田拓也
kn-aut-sei=永田
kn-aut-mei=拓也
aut-affil-num=4
ORCID=
en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=5
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター
affil-num=2
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター
affil-num=3
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター
affil-num=4
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター
affil-num=5
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター
END
start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=62
end-page=67
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Emphysematous changes of the lungs in asthmatics in the elderly. Differences between hyperinflation of the lungs by aging and pulmonary emphysema
kn-title=高齢者喘息における気腫化傾向 - 加齢変化と病的変化（肺気腫）の相違点
en-subtitle=
kn-subtitle=
en-abstract=Pathophysiological changes by aging were examined in asthmatics in the elderly.
1 . A level of serum IgE and frequency of positive RAST score
for allergens were in general low. However, the frequency of patients with family history of allergic diseases was considerably high, and in these patients with family history having allergic diseases the presence of IgE-mediated allergic reaction was frequently observed.
2 . Bronchial hyperresponsiveness tended to decrease with
aging.
3 . Ventilatory function and gas exchange (DLco) showed a decrease with aging, and the decrease in ventilatory function and DLco in older patients over age 70 was significantly
lower than the decrease in younger patients with asthma under age 49.
4 . The volume of the lungs, evaluated by % residual volume (% RV) , tended to increase with aging. The low attenuation
area (LAA) of the lungs < -950 HU on HRCT, which represents hyperinflation in asthma, was also increased with aging. A significant correlation was found between % RV and % LAA of
the lungs <-950HU on HRCT in patients over age 70.
kn-abstract=高齢者喘息の病態的特徴を臨床的に観察した。その結果は以下のごとくであった。
1．血清IgE値や抗原に対するIgE抗体の陽性率は一般的に低いが，しかしアレルギー疾患の家族歴を有する症例の頻度は高く，アトピー性の素因を有する症例の頻度がかなり高いこと，そして，このような症例ではIgE系反応の関与が示唆された。
2．気道過敏性は加齢とともに低下する傾向が見られた。
3．換気機能，ガス交換能は加齢とともに低下し，特に70才以上
の症例では若青年者喘息と比べ有意の低下が見られた。
4．肺容積は，加齢とともに増大し，70才以上の症例では有意の増大傾向が見られた。また，この肺容積の増大は，HRCT上の－950HU以下の肺% UIAと有意の相関が見られ，肺の過膨張の状態が存在することが示唆された。
en-copyright=
kn-copyright=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光廷文裕
kn-aut-sei=光廷
kn-aut-mei=文裕
aut-affil-num=1
ORCID=
en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=2
ORCID=
en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=3
ORCID=
en-aut-name=IwagakiNaofumi
en-aut-sei=Iwagaki
en-aut-mei=Naofumi
kn-aut-name=岩垣尚史
kn-aut-sei=岩垣
kn-aut-mei=尚史
aut-affil-num=4
ORCID=
en-aut-name=NagataTakuya
en-aut-sei=Nagata
en-aut-mei=Takuya
kn-aut-name=永田拓也
kn-aut-sei=永田
kn-aut-mei=拓也
aut-affil-num=5
ORCID=
en-aut-name=FujiiMakoto
en-aut-sei=Fujii
en-aut-mei=Makoto
kn-aut-name=藤井誠
kn-aut-sei=藤井
kn-aut-mei=誠
aut-affil-num=6
ORCID=
en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=7
ORCID=
en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=8
ORCID=
en-aut-name=HamadaMasanori
en-aut-sei=Hamada
en-aut-mei=Masanori
kn-aut-name=浜田全紀
kn-aut-sei=浜田
kn-aut-mei=全紀
aut-affil-num=9
ORCID=
en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=10
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=2
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=3
en-affil=
kn-affil=岡山大学医学部・学部附属病院三朝医療センター 内科
affil-num=4
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=5
en-affil=
kn-affil=岡山大学医学部・学部附属病院三朝医療センター 内科
affil-num=6
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=7
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター リハビリテーション科
affil-num=8
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター リハビリテーション科
affil-num=9
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=10
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
en-keyword=lgE系反応 (IgE-mediated allergy)
kn-keyword=lgE系反応 (IgE-mediated allergy)
en-keyword=気道過敏性 (bronchial hyperresponsiveness)
kn-keyword=気道過敏性 (bronchial hyperresponsiveness)
en-keyword=換気機能 (ventilatory function)
kn-keyword=換気機能 (ventilatory function)
en-keyword=ガス交換能 (gas exchange)
kn-keyword=ガス交換能 (gas exchange)
en-keyword=気腫化傾向 (emphysematous changes)
kn-keyword=気腫化傾向 (emphysematous changes)
END
start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=48
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=QOL in LBP patients
kn-title=温泉療法が腰痛症患者のQOLに及ぼす効果
en-subtitle=
kn-subtitle=
en-abstract=We have recently regarded the QOL as an important index in the treatment of disease. SF-36 is a measure of HRQOL made as an international standard. We investigated the QOL in LBP patients who underwent rehabiritation in our hospital using SF-36. We calculated PCS and MCS of SF-36. PCS went up from 41.1 to 43.6. MCS went up from 49.1 to 51.0. The spa therapy for LBP patients was effective.
kn-abstract=近年QOLが重視されるようになってきている。MOS short form 36 health survey（以下SF-36と略す）は，国際的レベルでの基準とされるべく開発された非疾患特異的HRQOL尺度である。今回，我々は当院でリハビリテーションをうけている腰痛症患者を対象に温泉療法のQOLに対する効果をSF－36を用いて調べた。SFL36の8項目をそれぞれ算出し，温泉療法前後での比較を行った。PCSは41.1から43.6へ, MCSは49.1から5l.0へ上昇したことより，身体・精神面ともに効果があると考えられた。
en-copyright=
kn-copyright=
en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=1
ORCID=
en-aut-name=SendaMasuo
en-aut-sei=Senda
en-aut-mei=Masuo
kn-aut-name=千田益生
kn-aut-sei=千田
kn-aut-mei=益生
aut-affil-num=2
ORCID=
en-aut-name=HamadaMasanori
en-aut-sei=Hamada
en-aut-mei=Masanori
kn-aut-name=浜田全紀
kn-aut-sei=浜田
kn-aut-mei=全紀
aut-affil-num=3
ORCID=
en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光廷文裕
kn-aut-sei=光廷
kn-aut-mei=文裕
aut-affil-num=4
ORCID=
en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保崎泰弘
kn-aut-sei=保崎
kn-aut-mei=泰弘
aut-affil-num=5
ORCID=
en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=6
ORCID=
en-aut-name=IwagakiNaofumi
en-aut-sei=Iwagaki
en-aut-mei=Naofumi
kn-aut-name=岩垣尚史
kn-aut-sei=岩垣
kn-aut-mei=尚史
aut-affil-num=7
ORCID=
en-aut-name=NagataTakuya
en-aut-sei=Nagata
en-aut-mei=Takuya
kn-aut-name=永田拓也
kn-aut-sei=永田
kn-aut-mei=拓也
aut-affil-num=8
ORCID=
en-aut-name=FujiiMakoto
en-aut-sei=Fujii
en-aut-mei=Makoto
kn-aut-name=藤井誠
kn-aut-sei=藤井
kn-aut-mei=誠
aut-affil-num=9
ORCID=
en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=10
ORCID=
en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=11
ORCID=
en-aut-name=InoueHajime
en-aut-sei=Inoue
en-aut-mei=Hajime
kn-aut-name=井上一
kn-aut-sei=井上
kn-aut-mei=一
aut-affil-num=12
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター リハビリテーション科
affil-num=2
en-affil=
kn-affil=岡山大学附属病院リハビリテーション部
affil-num=3
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=4
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=5
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=6
en-affil=
kn-affil=岡山大学医学部・学部附属病院三朝医療センター 内科
affil-num=7
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=8
en-affil=
kn-affil=岡山大学医学部・学部附属病院三朝医療センター 内科
affil-num=9
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=10
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター リハビリテーション科
affil-num=11
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院三朝医療センター 内科
affil-num=12
en-affil=
kn-affil=岡山大学附属病院整形外科
en-keyword=SF-36
kn-keyword=SF-36
en-keyword=生活の質 (QuaIity of Life)
kn-keyword=生活の質 (QuaIity of Life)
en-keyword=腰痛症 (Low back Pain)
kn-keyword=腰痛症 (Low back Pain)
END
start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=42
end-page=47
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=IgE系アレルギー反応はアトピー型気管支喘息の白血球ロイコトリエンB4（LTB4）およびC4（LTC4）産生を促進させ，喫煙は気道過敏性を亢進させる
kn-title=IgE-mediated allergy and cigarette smoking enhancethe generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes and bronchial hyperresponsiveness in patients with atopic asthma
en-subtitle=
kn-subtitle=
en-abstract=ハウスダストあるいカンジダ抗原に対して特異的IgE抗体が陽性を示す気管支喘息69例を対象に，IgE系反応と喫煙の，気道過敏性および白血球のLTB4,LTC4産生に対する影響について検討を加えた。
1．気道過敏性は，非喫煙者に比べ喫煙者でより高度であることが明らかにされた。
2．白血球のLTC4，LVC4産生は，血清IgE値が351単位/ml以上の非喫煙症例で150単位以下および151－350単位/mlの症例に比べ有意に高い値を示した（m4：p＜0．01，LTC4：p＜0．05）。
3．長期間の副腎皮質ホルモン投与は，LTC4産生を抑制したが，気道過敏性およびLTB4産生には影響しなかった。
4．今回のようなアトピー型喘息では，気道過敏性と年令の間には有意の相関は見られなかった。以上の結果より，アトピー喘息では，IgE系反応は白血球のLTB4，LTC4産生を促進させ，また喫煙は気道過敏性を促進させることが明らかになった。
kn-abstract=Influences of IgE-mediated allergy and cigarette smoking on pathophysiology, evaluated by bronchial hyperresponsiveness and the generation of LTB4 and LTC4, of asthma were examined in 69 patients with asthma sensitive to inhalant allergens such as house dust mite and Candida albicans.
1 . Bronchial byperresponsiveness was significantly higher in previous and current smokers of asthmatics than in never-smokers. 2 . The generation of leukotrienes 84 (LTB4) and C4 (LTC4) by leucocytes was significantly larger in patients with serum IgE over 350 IU/ml than in those with serum IgE less than 150 IU/ml (LTB4 : p