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JaLCDOI 10.18926/AMO/55204
フルテキストURL 71_3_219.pdf
著者 Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira|
抄録  Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
キーワード oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-06
巻 71巻
号 3号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 226
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28655941
JaLCDOI 10.18926/AMO/55203
フルテキストURL 71_3_209.pdf
著者 Xin, Zhao| Tsuda, Toshihide| Doi, Hiroyuki|
抄録 We evaluated how exposure to airborne volatile organic compounds emitted from a plastic recycling facility affected nearby residents, in a cross-sectional study. Individuals>10 years old were randomly sampled from 50 households at five sites and given questionnaires to complete. We categorized the subjects by distance from the recycling facility and used this as a proxy measure for pollutant exposure. We sought to improve on a preceding study by generating new findings, improving methods for questionnaire distribution and collection, and refining site selection. We calculated the odds of residents living 500 or 900 m away from the facility reporting mucocutaneous and respiratory symptoms using a reference group of residents 2,800 m away. Self-reported nasal congestion (odds ratio=3.0, 95% confidence interval=1.02-8.8), eczema (5.1, 1.1-22.9), and sore throat (3.9, 1.1-14.1) were significantly higher among residents 500 m from the facility. Those 900 m away were also considerably more likely to report experiencing eczema (4.6, 1.4-14.9). Air pollution was found responsible for significantly increased reports of mucocutaneous and respiratory symptoms among nearby residents. Our findings confirm the effects of pollutants emitted from recycling facilities on residents’ health and clarify that study design differences did not affect the results.
キーワード air pollutants volatile organic compounds recycling facility mucocutaneous symptoms respiratory symptoms
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-06
巻 71巻
号 3号
出版者 Okayama University Medical School
開始ページ 209
終了ページ 217
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28655940
JaLCDOI 10.18926/AMO/55202
フルテキストURL 71_3_201.pdf
著者 Matsuda, Miwa| Sasaki, Aiko| Shimizu, Keiko| Kamada, Yasuhiko| Noguchi, Soichi| Hiramatsu, Yuji| Nakatsuka, Mikiya|
抄録  Vascular dysfunction has been reported in women with recurrent pregnancy loss (RPL). We investigated the severity of vascular dysfunction in non-pregnant women with RPL and its correlation with anti-heat shock protein (HSP) antibodies that are known to induce arteriosclerosis. We measured the serum anti-HSP60 antibodies, anti-HSP70 antibodies, and anti-phospholipid antibodies (APA) in 68 women with RPL and 29 healthy controls. Among the women with RPL, 14 had a diagnosis of antiphospholipid syndrome (APS), and in the remaining 54, the causes for RPL were unexplained. Compared to the controls, the brachial-ankle pulse wave velocity (baPWV), carotid augmentation index (cAI), and uterine artery pulsatility index (PI) were all significantly higher in the women with both APS and unexplained RPL. Compared to the controls, the anti-HSP60 antibody levels were significantly higher in the APA-positive group of women with unexplained RPL, and the anti-HSP70 antibody levels were significantly higher in APS and APA-positive group of women with unexplained RPL. However, the anti-HSP60 and anti-HSP70 antibody levels did not correlate with the values of baPWV or cAI. Our results demonstrated anti-HSP60 and anti-HSP70 antibodies are increased in women with unexplained RPL. Further studies are needed to elucidate the roles of anti-HSP antibodies and their pathophysiology in unexplained RPL.
キーワード recurrent pregnancy loss autoantibody heat shock protein pulse wave velocity arterial stiffness
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-06
巻 71巻
号 3号
出版者 Okayama University Medical School
開始ページ 201
終了ページ 208
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28655939
JaLCDOI 10.18926/AMO/55201
フルテキストURL 71_3_191.pdf
著者 Kobayashi, Katsuhiro| Akiyama, Tomoyuki| Agari, Takashi| Sasaki, Tatsuya| Shibata, Takashi| Hanaoka, Yoshiyuki| Akiyama, Mari| Endoh, Fumika| Oka, Makio| Date, Isao|
抄録  Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
キーワード fast oscillations, epilepsy electroencephalogram time-frequency analysis
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2017-06
巻 71巻
号 3号
出版者 Okayama University Medical School
開始ページ 191
終了ページ 200
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28655938
フルテキストURL K0005453_other1.pdf
著者 Nobumoto, Etsuko| Masuyama, Hisashi| Hiramatsu, Yuji| Sugiyama, Takashi| Kusaka, Hideto| Toyoda, Nagayasu|
キーワード New GDM criteria Perinatal complications Obesity 75-g oral glucose tolerance test
備考 The final publication is available at Springer| 学位審査副論文|
発行日 2015-09
出版物タイトル Diabetology International
巻 6巻
号 3号
出版者 Springer Japan
開始ページ 226
終了ページ 231
ISSN 21901678
NCID AA12503387
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
DOI 10.1007/s13340-014-0193-8
Web of Science KeyUT 000366631000009
関連URL http://doi.org/10.1007/s13340-014-0193-8 http://ousar.lib.okayama-u.ac.jp/55005
フルテキストURL J_Comp_Neurol_525_7_1586.pdf
著者 Tamura, Kei| Kobayashi, Yasuhisa| Hirooka, Asuka| Takanami, Keiko| Oti, Takumi| Jogahara, Takamichi| Oda, Sen-ichi| Sakamoto, Tatsuya| Sakamoto, Hirotaka|
キーワード RRID AB_2060157 RRID: AB_2571636 RRID: AB_626757 Suncus murinus (suncus) gastrin-releasing peptide male reproductive function sexual dimorphism spinal cord
備考 This is the peer reviewed version of the following article: Tamura K. Kobayashi Y. Hirooka A. et al. Identification of the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function in the mouse and Asian house musk shrew (Suncus murinus). J Comp Neurol. 2017;525:1601–1613. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.| 2018年5月公開予定|
発行日 2017-05-01
出版物タイトル Journal of Comparative Neurology
巻 525巻
号 7号
出版者 Wistar Institute of Anatomy and Biology
開始ページ 1586
終了ページ 1598
ISSN 0021-9967
NCID AA00695917
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 27804131
DOI 10.1002/cne.24138
Web of Science KeyUT 000397559700004
関連URL https://doi.org/10.1002/cne.24138
フルテキストURL JoAmChemSoc_2017_139_12_4376.pdf
著者 Niho, Akiko| Yoshizawa, Susumu| Tsukamoto, Takashi| Kurihara, Marie| Tahara, Shinya| Nakajima, Yu| Mizuno, Misao| Kuramochi, Hikaru| Tahara, Tahei| Mizutani, Yasuhisa| Sudo, Yuki|
備考 This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher.|
発行日 2017-03-29
出版物タイトル Journal of the American Chemical Society
巻 139巻
号 12号
出版者 American Chemical Society
開始ページ 4376
終了ページ 4389
ISSN 00027863
NCID AA00692602
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 28257611
DOI 10.1021/jacs.6b12139
Web of Science KeyUT 000398247100034
関連URL isVersionOf https://doi.org/10.1021/jacs.6b12139
フルテキストURL Acta_Biomater_2017_5.pdf
著者 Okada, Masahiro| Nakai, Akira| Hara Emilio, Satoshi| Taguchi, Tetsushi| Nakano, Takayoshi| Matsumoto, Takuya|
キーワード Hydroxyapatite Nanoparticle Solid adhesive Wet adhesion
発行日 2017-05
出版物タイトル Acta Biomaterialia
巻 57巻
出版者 Elsevier B.V.
開始ページ 404
終了ページ 413
ISSN 1742-7061
NCID AA12033647
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
論文のバージョン author
PubMed ID 28483692
DOI 10.1016/j.actbio.2017.05.014
Web of Science KeyUT 000405041900035
関連URL https://doi.org/10.1016/j.actbio.2017.05.014
タイトル(別表記) Organization and Rules of the Association
フルテキストURL poalas_033_065_066.pdf
著者 岡山実験動物研究会|
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 65
終了ページ 66
言語 日本語
論文のバージョン publisher
タイトル(別表記) Member Directory
著者 岡山実験動物研究会|
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 60
終了ページ 64
言語 日本語
論文のバージョン publisher
タイトル(別表記) By-Low of membership fee and Notes of Contributors
フルテキストURL poalas_033_059.pdf
著者 岡山実験動物研究会|
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 59
終了ページ 59
言語 日本語
論文のバージョン publisher
タイトル(別表記) 71th and 72th Meeting News, and the Secretary Meeting News
フルテキストURL poalas_033_048_058.pdf
著者 岡山実験動物研究会|
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 48
終了ページ 59
言語 日本語
論文のバージョン publisher
タイトル(別表記) Introduction to the activities of the Regional Associations for Laboratory Animal Science
フルテキストURL poalas_033_040_047.pdf
著者 岡山実験動物研究会|
抄録 わが国には現在11 の地区研究会があり、独自の活動が展開されています。本報では、各地区研究会の間での情報交換、交流などを意図して、平成28 年度の活動について北から順に紹介します。 なお、会長、事務局担当者及び講演者、話題提供者の方々のお名前は敬称を省略させていただきました。詳細な内容をご希望の方は各地区研究会の事務局にお問い合わせ下さい。
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 40
終了ページ 47
言語 日本語
論文のバージョン publisher
タイトル(別表記) Introduction of Laboratory Animal Facilities in the Life Science Research Center, Gifu University
フルテキストURL poalas_033_035_039.pdf
著者 二上 英樹|
抄録 The facilities of laboratory animal within the Division of Animal Experiments, Life Science Research Center, Gifu University was established in April 2005. In order to gain reliable data from animal experiments, it is vital that the subjects' environment be stable and well-controlled. In addition, the safety impact to humans and bioethical rules must be considered when conducting animal experiments. We provide both the facilities necessary for such experiments as well as comprehensive support in the form of experiment program planning and subject care and maintenance.
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 35
終了ページ 39
言語 日本語
論文のバージョン publisher
タイトル(別表記) Identification of Marker Gene of Pars Tuberalis Morphogenesis in Chicken Embryo. The expression of Cytokine-like 1 and Gap junction protein alpha 5 in the pars tuberalis
フルテキストURL poalas_033_031_034.pdf
著者 相澤 清香| 檜垣 佑理子| 御輿 真穂| 竹内 栄| 高橋 純夫|
抄録 Adenohypophysis delivered from oral ectoderm consists of pars distalis (PD), pars intermedia and pars tuberalis (PT). The mechanisms of development of PD has been well studied, and the cell differentiation of PD has been well understood. However, the morphogenesis and the differentiation of PT are still unclear, and the gene expression during the PT development remains largely unknown. In this study, we explored the specifically expressing genes in PT during development and analyzed its spatiotemporal expressions pattern. Microarray analysis on laser-captured PT and PD tissues obtained from chicken embryos on embryonic day 10 (E10.0) showed high expressing genes, Cytokine-like 1 (CYTL1) and Gap junction protein alpha 5 (GJA5) in PT. A detail analysis of spatiotemporal expressions pattern during chick embryo development by in situ hybridization revealed that CYTL1 mRNA was first detected in lateral head ectoderm and ventral head ectoderm in E1.5. The CYTL1 expressions moved into Rathke’s pouch at E2.5, then it was localized in PT primordium and continuously expressed in PT primordium until E12.0. On the other hand, GJA5 mRNA was transiently detected in PT primordium from E6 to E14.0, while the expression was not detected in PD during development. These results suggested that these genes may be involved in the regulation mechanism of PT development and could be a useful marker in the PT development.
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 31
終了ページ 34
言語 日本語
論文のバージョン publisher
タイトル(別表記) Structure and function of tegmentum vasculosum in avian cochlea
フルテキストURL poalas_033_026_030.pdf
著者 池田 理佐| 乙野 剛史| 池田 直矢| 齋藤 昇| 安藤 元紀|
抄録 In spite of the importance of endocochlear DC potential (EP) and the K+-rich endolymph for the avian cochlea, the structure and function of the tegmentum vasculosum (TV) has not yet been fully elucidated, compared with those of the stria vascularis in the mammalian cochlea. In this study, we examined structural analysis of the epithelial cells, gene expressions of Na+-K+-ATPase (Atp1A1) and Kir4.1 (Kcnj10), and protein localizations of Na+-K+-ATPase and Kir4.1, in the TV. Tight junctional structures were observed between epithelial dark cells and light cells in the TV. Both Atp1a1 and Kcnj10 genes were detected in the TV. In addition, immunopositive signals for both Na+-K+-ATPase and Kir4.1 were recognized in the TV. These results indicate that Na+-K+-ATPase and Kir4.1 play roles in maintaining the EP and high K+ concentration of the endolymph. Further studies are needed to clarify the physiological functions of the TV. This is the first report which demonstrates that gene and protein expression data contribute to the avian inner ear homeostasis.
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 26
終了ページ 30
言語 日本語
論文のバージョン publisher
タイトル(別表記) Taxonomic status of Aco strain derived from spiny mice
フルテキストURL poalas_033_022_025.pdf
著者 持田 瞳| 目加田 和之|
抄録 Spiny mice are useful in regenerative research and as a model for precocial animals. In the present study, we investigated the taxonomic status of the Aco strain, which is derived from spiny mice of an unidentified species. Although this Aco strain has been tentatively considered A. cahirinus species, it was distinguished from this species based on conventional and G-banding chromosomal patterns of this strain. Subsequently, we determined the nucleotide sequence of the mitochondorial gene cytochrome b (Cyb) and constructed a molecular phylogenetic tree. We found that the Aco strain belongs to the same clade as A. dimidiatus. Based on this molecular analysis, we concluded that the Aco strain of spiny mice should be considered A. dimidiatus.
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 22
終了ページ 25
言語 日本語
論文のバージョン publisher
タイトル(別表記) Inhibitory effects of caffeine on allergic rhinitis symptoms in mice
フルテキストURL poalas_033_018_021.pdf
著者 辻本 まどか| 佐伯 綾希子| 鈴木 真奈美| 白神 俊幸| 杉本 幸雄| 林 泰資|
抄録 We examined the effects of caffeine treatment on ovalbumin- and histamine-induced rhinitis mouse models and on corticosterone and catecholamine levels in mouse plasma. Treatment with caffeine decreased sneezing and nasal rubbing in both models, but direct nasal administration had no effect. Plasma levels of corticosterone and catecholamine, which have known anti-allergy effects, were increased by caffeine treatment. The increases in corticosterone and catecholamine may be associated with the suppression of rhinitis symptoms.
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 18
終了ページ 21
言語 日本語
論文のバージョン publisher
タイトル(別表記) Dissecting the hierarchy and lineage of mesenchymal stem cells by mouse genetics
フルテキストURL poalas_033_015_017.pdf
著者 宝田 剛志|
抄録 Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, including the mechanisms of tissue development and maintenance of tissue homeostasis, as well as disease development. It also has implications in the field of tissue regeneration for medical treatments and disease modeling for drug discovery using iPS technology. Mesenchymal stem cells are multipotent stem cell that can differentiate into various type of cells including osteoblasts, adipocytes, myocytes and chondrocytes. Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation. Runx2 deficiency in Prx1+-derived cells (Runx2prx1−/− mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1− cells. Our results suggest that osteoblast differentiation in vivo may begin at the Prx1+Sca1+ MSC stage with sequential progression to Prx1+Sca1−cells, then Osx+Prx1−Sca1− osteoblast precursors, which eventually form mature α1(I)-collagen+ osteoblasts.
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 15
終了ページ 17
言語 日本語
論文のバージョン publisher
タイトル(別表記) Contribution and progress of the gnotobiote technology in gut microbiome research
フルテキストURL poalas_033_011_014.pdf
著者 森田 英利|
出版物タイトル 岡山実験動物研究会報
発行日 2017-04
巻 33巻
開始ページ 11
終了ページ 14
言語 日本語
論文のバージョン publisher