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kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=59 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=75th and 76th Meeting News, and the Secretary Meeting News kn-title=第75 回、第76 回研究会例会、理事会報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=46 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Contents of the Proceedings of the Okayama Association for Laboratory Animal Science : From No.1 to 35 kn-title=岡山実験動物研究会報第1 号から第３５号までの掲載内容 en-subtitle= kn-subtitle= en-abstract= kn-abstract= The Proceedings of the Okayama Association for Laboratory Animal Science were initially issued in 1983, the year following the establishment of the association, and No.35 is the latest.Scince issue No.2, the proceedings have consisted of the following content: , , , , , and , in this order. Additionally, the publication of references and advertisements by supporting members recently started. Number 19 (issued in 2002) was the first to present a table of contents in English on its back cover, and this style has been maintained to date. On March 24, the president of the association and director of the Okayama University Libraries exchanged copies of an agreement regarding the registration of these contents with the Okayama University Scientific Achievement Repository (OUSAR) and other databases, providing a basis for their current registration and publication. Literature-based information is also being collected and published in databases organized by the Non-profit Organization Japan Medical Abstracts Society (Ichushi) and Japan Science & Technology Agency (JST). en-copyright= kn-copyright= en-aut-name=SatoKatsunori en-aut-sei=Sato en-aut-mei=Katsunori kn-aut-name=佐藤勝紀 kn-aut-sei=佐藤 kn-aut-mei=勝紀 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Animal Resources, Tsushima South Laboratory, Advanced Science Research Center, Okayama University kn-affil=岡山大学自然生命科学研究支援センター・動物資源部門・津島南施設 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=38 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction to the activities of the Regional Associations for Laboratory Animal Science kn-title=地区研究会の活動紹介 en-subtitle= kn-subtitle= en-abstract= There are eleven Regional Associations for Laboratory Animal Science in Japan, and each of them conducts independent activities. The present paper introduces the activities of the Regional Associations in 2017 to promote information exchange and interaction among them, starting from those of the northernmost association. In the paper, honorifics for the staff of the office, lecturers, and people who provided us with information on topics have been omitted. For the details, please contact the office of each Regional Association. kn-abstract= わが国には現在11 の地区研究会があり、独自の活動が展開されています。本報では、各地区研究会の間での情報交換、交流などを意図して、平成30 年度の活動について北から順に紹介します。なお、会長、事務局担当者及び講演者、話題提供者の方々のお名前は敬称を省略させていただきました。詳細な内容をご希望の方は各地区研究会の事務局にお問い合わせ下さい。 en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=29 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction of Center for Comparative Medicine, Hyogo College of Medicine based on concept of laboratory animal allergy prevention kn-title=実験動物アレルギー予防を目指した兵庫医科大学 病態モデル研究センターの紹介 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Laboratory animal allergy (LAA) is an important problem on considering the occupational safety and health of animal workers. The Center for Comparative Medicine (CCOM), Hyogo College of Medicine, opened on April 1, 2018, is an animal experiment facility designed and constructed based on the concept of LAA prevention. This CCOM is located on the first and second floors of a newly built "education? research building". Methods for the prevention of LAA are airflow control by air conditioning equipment, breeding equipment, experimental equipment, cage transporters that suppress the diffusion of aero allergens, spraying of slightly acidic water mist, and prevention of allergen exposure by the strict use of Personal Protective Equipment (PPE). In addition, we implemented training on LAA and take measures to prevent office workers from being exposed to laboratory animal-derived allergens. en-copyright= kn-copyright= en-aut-name=SagaraEiji en-aut-sei=Sagara en-aut-mei=Eiji kn-aut-name=佐加良英治 kn-aut-sei=佐加良 kn-aut-mei=英治 aut-affil-num=1 ORCID= affil-num=1 en-affil=Center for Comparative Medicine, Hyogo College of Medicine kn-affil=兵庫医科大学 病態モデル研究センター END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=26 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Challenge to hand-rear of the common marmoset kn-title=コモンマーモセットを育てる en-subtitle= kn-subtitle= en-abstract= kn-abstract= In mid July 2018, the common marmoset bred in Okayama University gave birth to a triplet. It is very difficult to raise three infants. We selected the most heaviest one of her siblings, and we call her “POCKE”. We brought her up on the bottle for 80 days from the birth instead of her own mother. After 81 days, she finaly weand. Now she has become attached to human, but we hope that she gets back to their original community, as a “common” marmoset. en-copyright= kn-copyright= en-aut-name=HashimotoHaruna en-aut-sei=Hashimoto en-aut-mei=Haruna kn-aut-name=橋本春菜 kn-aut-sei=橋本 kn-aut-mei=春菜 aut-affil-num=1 ORCID= affil-num=1 en-affil=Advanced Science Research Center, Okayama University kn-affil=岡山大学 自然生命科学研究支援センター END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=22 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Biochemical Evaluation of Maternal Stress by Separating Infant Mice for Animal Experiments kn-title=新生児マウスを用いる動物実験が母マウスにもたらすストレスの生化学的評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Corticosterone, the glucocorticoid in rodents, is released from adrenal cortex in response to stress. Sometimes, for use in experiments, infants may be separated from their mother mouse. We studied the stress of mother mouse when she separates from infants. As a result, the concentration of corticosterone in the blood of the mother mouse tended to increase, by pulling her infants apart. In the case of using infant mice for animal experiments, it was suggested that it is necessary to consider the maternal stress. en-copyright= kn-copyright= en-aut-name=YataNorio en-aut-sei=Yata en-aut-mei=Norio kn-aut-name=矢田範夫 kn-aut-sei=矢田 kn-aut-mei=範夫 aut-affil-num=1 ORCID= affil-num=1 en-affil=Advanced Science Research Center, Okayama University kn-affil=岡山大学 自然生命科学研究支援センター END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=18 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=What kind of environmental enrichment does mother mouse want? kn-title=母マウスが望む環境エンリッチメントとは？ : 環境エンリッチメント選びを考える en-subtitle= kn-subtitle= en-abstract= kn-abstract= Environmental enrichment, whose material is commercially available, is today thought to improve animal welfare, for instance, control of stress. There were some reports that these report contribution of suppression of stress, which the mother mice suffer during nursing their pup. However, the effects on stress-suppression by introducing the enrichment materials is unknown. In this study, determined plasma and urinary corticosterone in the mother mice with or without the materials from their making to weaning. en-copyright= kn-copyright= en-aut-name=IshiharaSumire en-aut-sei=Ishihara en-aut-mei=Sumire kn-aut-name=石原すみれ kn-aut-sei=石原 kn-aut-mei=すみれ aut-affil-num=1 ORCID= affil-num=1 en-affil=Advanced Science Research Center, Okayama University kn-affil=岡山大学 自然生命科学研究支援センター END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=12 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Species identification of a laboratory strain belonging to the family Arvicolinae kn-title=種名が不明なミズハタネズミ亜科系統の種の同定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= This study investigated the taxonomic status of a laboratory strain belonging to the family Arvicolinae for which the wild species name is unknown. This vole strain, though considered formerly a Lemming, was distinguishable from any Lemmus species by features of its appearance, skull and molar morphology, and conventional chromosomal pattern. Subsequently, we read the nucleotide sequence of the mitochondrial cytochrome b (Cyb) gene and constructed a molecular phylogenetic tree. We found that this vole strain belongs to the same clade as Microtus guenthe en-copyright= kn-copyright= en-aut-name=TakahataSatoshi en-aut-sei=Takahata en-aut-mei=Satoshi kn-aut-name=高畑智 kn-aut-sei=高畑 kn-aut-mei=智 aut-affil-num=1 ORCID= en-aut-name=IsemuraNatsumi en-aut-sei=Isemura en-aut-mei=Natsumi kn-aut-name=伊勢村夏実 kn-aut-sei=伊勢村 kn-aut-mei=夏実 aut-affil-num=2 ORCID= en-aut-name=MekadaKazuyuki en-aut-sei=Mekada en-aut-mei=Kazuyuki kn-aut-name=目加田和之 kn-aut-sei=目加田 kn-aut-mei=和之 aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Zoology, Faculty of Science, Okayama University of Science kn-affil=岡山理科大学 理学部 動物学科 affil-num=2 en-affil=Department of Zoology, Faculty of Science, Okayama University of Science kn-affil=岡山理科大学 理学部 動物学科 affil-num=3 en-affil=Department of Zoology, Faculty of Science, Okayama University of Science kn-affil=岡山理科大学 理学部 動物学科 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=9 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Reactivity of secretory immunoglobulin A against gut bacteria is attenuated by high-fat diet consumption kn-title=分泌型免疫グロブリンA の腸内細菌への結合活性は 高脂肪食の摂取により弱まる en-subtitle= kn-subtitle= en-abstract= kn-abstract= Secretory immunoglobulin A (SIgA) is predominant antibody secreted into the gut relating to maintain gut homeostasis. In the present study, we focused on the SIgA coating of gut bacteria as a mucosal immune response affecting the gut bacteria following a high-fat diet (HFD). This study newly showed that the level of SIgA coating of gut bacteria was significantly decreased in HFD-fed mice than normal-fat diet (NFD)-fed mice. Furthermore, we found that the relative abundances of gut bacteria were significantly negatively or positively correlated with the level of SIgA coating of gut bacteria in NFD-fed and HFD-fed mice. Our observations suggest that a decrease in the level of SIgA coating of the gut bacteria through a HFD might relate to HFD-induced changes in bacterial composition. en-copyright= kn-copyright= en-aut-name=TsurutaTakeshi en-aut-sei=Tsuruta en-aut-mei=Takeshi kn-aut-name=鶴田剛司 kn-aut-sei=鶴田 kn-aut-mei=剛司 aut-affil-num=1 ORCID= en-aut-name=MUHOMAHTeresia Aluoch en-aut-sei=MUHOMAH en-aut-mei=Teresia Aluoch kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SonoyamaKei en-aut-sei=Sonoyama en-aut-mei=Kei kn-aut-name=園山慶 kn-aut-sei=園山 kn-aut-mei=慶 aut-affil-num=3 ORCID= en-aut-name=NishinoNaoki en-aut-sei=Nishino en-aut-mei=Naoki kn-aut-name=西野直樹 kn-aut-sei=西野 kn-aut-mei=直樹 aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate school of Environmental and Life Sciences, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 affil-num=2 en-affil=Graduate school of Environmental and Life Sciences, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 affil-num=3 en-affil=Research Faculty of Agriculture, Hokkaido University kn-affil=北海道大学大学院農学研究院 affil-num=4 en-affil=Graduate school of Environmental and Life Sciences, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=2 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The mammalian pigmentary system - a model experimental system for exploring the functional divergence of a differentiated cell type kn-title=色素細胞系 : 生命機能発現機構解明の１モデルシステム en-subtitle= kn-subtitle= en-abstract= kn-abstract= There are two cell lineages of mammalian melanin pigment cells, one that leads to retinal pigment epithelium (RPE) cells in the eye from the optic cup and the other leading to melanocytes from vertebrate-specific neural crest cells. Melanocyte precursors have high mobility and migrate and settle into various tissues and organs, including the skin, choroid, inner ear, heart, brain, adipose tissue, lung, etc. It is well known that RPE cells are essential for visual acuity and that melanocytes in the skin provide protection against UV-damage. So, what is the function of extracutaneous melanocytes that are distributed elsewhere in the body where only very small amounts of light illuminate their existence? Here I would like to briefly introduce our research history and then discuss the important roles of melanocytes in the inner ear that are indispensable for hearing ability and those in the choroid where they seem to contribute to maintaining the structures of their habitats. en-copyright= kn-copyright= en-aut-name=YamamotoHiroaki en-aut-sei=Yamamoto en-aut-mei=Hiroaki kn-aut-name=山本博章 kn-aut-sei=山本 kn-aut-mei=博章 aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Bioscience Nagahama Institute of Bio-Science and Technology kn-affil=長浜バイオ大学バイオサイエンス学部 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page=1 end-page=1 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=会長あいさつ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MominokiKatsumi en-aut-sei=Mominoki en-aut-mei=Katsumi kn-aut-name=樅木勝巳 kn-aut-sei=樅木 kn-aut-mei=勝巳 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Animal Resources, Advanced Science Research Center, Okayama University kn-affil=岡山大学自然生命科学研究支援センター動物資源部門 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=サンプル保存条件，食事，腸内細菌叢が哺乳類メタボローム解析データに及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MoriyaTakeo en-aut-sei=Moriya en-aut-mei=Takeo kn-aut-name=守谷岳郎 kn-aut-sei=守谷 kn-aut-mei=岳郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=濾胞樹状細胞が産生するIL-34による胚中心反応の制御に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OgawaSayaka en-aut-sei=Ogawa en-aut-mei=Sayaka kn-aut-name=小川紗也香 kn-aut-sei=小川 kn-aut-mei=紗也香 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil=岡山大学大学院自然科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=マウス歯胚の発育に対する抗がん剤の影響についての組織学的および分子生物学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TsunodaYoko en-aut-sei=Tsunoda en-aut-mei=Yoko kn-aut-name=角田陽子 kn-aut-sei=角田 kn-aut-mei=陽子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=局所投与されたイバブラジンは過分極活性化環状ヌクレオチド依存性（HCN）チャネルを介してカラゲニンによって誘発された神経障害性疼痛および炎症反応を抑制する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyakeSaki en-aut-sei=Miyake en-aut-mei=Saki kn-aut-name=三宅沙紀 kn-aut-sei=三宅 kn-aut-mei=沙紀 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=出生後のマウス長管骨成長板の内軟骨性骨化におけるaggrecanの in vivo機能解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ToriharaHidemi en-aut-sei=Torihara en-aut-mei=Hidemi kn-aut-name=鳥原秀美 kn-aut-sei=鳥原 kn-aut-mei=秀美 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨細胞Sclerostinの脱負荷に伴う分布域変化の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OsumiRyuta en-aut-sei=Osumi en-aut-mei=Ryuta kn-aut-name=大住隆太 kn-aut-sei=大住 kn-aut-mei=隆太 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=歯周病原細菌を原因とするヒトと伴侶動物の犬における人獣共通感染症検査に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TaiMasako en-aut-sei=Tai en-aut-mei=Masako kn-aut-name=田井真砂子 kn-aut-sei=田井 kn-aut-mei=真砂子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue= article-no= start-page=19 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The List of Published by Members of the Faculty From January to December 2018 kn-title=公表学術論文等リスト 2018 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Faculty of Agriculture, Okayama University en-aut-sei=Faculty of Agriculture, Okayama University en-aut-mei= kn-aut-name=岡山大学農学部 kn-aut-sei=岡山大学農学部 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180927 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=オレキシンとBMPによる卵巣プロゲステロン産生への影響とその機序の検討 kn-title=Interaction between orexin A and bone morphogenetic protein system on progesterone biosynthesis by rat granulosa cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujitaShiho en-aut-sei=Fujita en-aut-mei=Shiho kn-aut-name=藤田志保 kn-aut-sei=藤田 kn-aut-mei=志保 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=慢性低灌流ラットに長期増強を行うことで海馬における神経分化が促進される kn-title=Long-Term Potentiation Enhances Neuronal Differentiation in the Chronic Hypoperfusion Model of Rats en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakeuchiHayato en-aut-sei=Takeuchi en-aut-mei=Hayato kn-aut-name=竹内勇人 kn-aut-sei=竹内 kn-aut-mei=勇人 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ラットのリンパ浮腫反応モデルにおいて、浅層のリンパ管は増加する kn-title=Enhancement of lymphatic vessels in the superficial layer in a rat model of a lymphedematous response en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsumotoKumi en-aut-sei=Matsumoto en-aut-mei=Kumi kn-aut-name=松本久美子 kn-aut-sei=松本 kn-aut-mei=久美子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=91 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organization and Rules of the Association kn-title=組織・会則 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=86 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Member Directory kn-title=会員名簿 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=85 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=By-Low of membership fee and Notes of Contributors kn-title=会費に関する内規、会報投稿規程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=74 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=73th and 74th Meeting News, and the Secretary Meeting News kn-title=第73回、第74回研究会、理事会報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract=寄稿（Contribution）は記入 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=54 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Thirty-five years activities of Okayama Association for Laboratory Animal Science kn-title=岡山実験動物研究会の３５年間の活動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Okayama Association for Laboratory Science, established on December 7, 1982, celebrates its 35th anniversary on December 7, 2017. The association was established to provide opportunities for researchers interested in laboratory animals and animal experiments to assemble beyond the borders of universities, faculties, and institutions to exchange their knowledge and information, as well as help promote their research activities and advancement of community science. The executives, auditors, and other members of the association have organized and held workshops and issued newsletters under the leadership of former presidents. The association has been able to implement research activities for a long period of time thanks to the advice of regular members and the support of supporting members. The workshops have been held twice a year since 1990. A total of 74 workshops(regular conferences), as well as symposiums, have been held and 33 research bulletins (proceedings) have been issued over the last 35 years. We have summarized the workshops and symposiums etc. that have been held. en-copyright= kn-copyright= en-aut-name=SatoKatsunori en-aut-sei=Sato en-aut-mei=Katsunori kn-aut-name=佐藤勝紀 kn-aut-sei=佐藤 kn-aut-mei=勝紀 aut-affil-num=1 ORCID= affil-num=1 en-affil=Honorary member in Okayama Association for Laboratoy Animal Science kn-affil=岡山実験動物研究会名誉会員 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=45 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction to the activities of the Regional Associations for Laboratory Animal Science kn-title=地区研究会の活動紹介 en-subtitle= kn-subtitle= en-abstract=There are eleven Regional Associations for Laboratory Animal Science in Japan, and each of them conducts independent activities. The present paper introduces the activities of the Regional Associations in 2017 to promote information exchange and interaction among them, starting from those of the northernmost association. In the paper, honorifics for the staff of the office, lecturers, and people who provided us with information on topics have been omitted. For the details, please contact the office of each Regional Association. kn-abstract=わが国には現在11 の地区研究会があり、独自の活動が展開されています。本報では、各地区研究会の間での情報交換、交流などを意図して、平成29 年度の活動について北から順に紹介します。なお、会長、事務局担当者及び講演者、話題提供者の方々のお名前は敬称を省略させていただきました。詳細な内容をご希望の方は各地区研究会の事務局にお問い合わせ下さい。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=40 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction of Experimental Animal Center, Joint Faculty of Veterinary Medicine, Kagoshima University kn-title=鹿児島大学共同獣医学部総合動物実験施設の紹介 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To improve the quality of education and research with laboratory animals, Experimental Animal Center (EAC) was established as an animal facility in the Joint Faculty of Veterinary Medicine, Kagoshima University, on September 1st, 2015. We can house and use large-sized (bovine and horse), medium-sized (dog, cat, pig and bird), and small-sized (rodent and rabbit) animals in this facility. Our care and use program of laboratory animals in EAC was fully accredited by AAALAC International on June 9th, 2016. We are using this facility to demonstrate to our students that performance of veterinary care and animal welfare is important for appropriate education and scientific research with laboratory animals in Veterinary Medicine. en-copyright= kn-copyright= en-aut-name=AsanoAtsushi en-aut-sei=Asano en-aut-mei=Atsushi kn-aut-name=浅野淳 kn-aut-sei=浅野 kn-aut-mei=淳 aut-affil-num=1 ORCID= affil-num=1 en-affil=Joint Faculty of Veterinary Medicine, Kagoshima University kn-affil=鹿児島大学共同獣医学部 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=36 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Deodorizing Effect of Weak Acid Hypochlorous Solution against Ammonia kn-title=弱酸性次亜塩素酸水溶液のアンモニアに対する消臭効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The deodorizing effect of weak acid hypochlorous solution against ammonia was investigated. When atomized particles of weak acid hypochlorous solution contacted ammonia, the ammonia concentration decreased in a concentration-dependent manner. The deodorizing effect was also observed against ammonia generated from the used floor cover for mice. When the floor mat was present, the ammonia concentration gently decreased but then rapidly decreased when the floor mat was removed. In the future, we will examine effective spraying conditions for weak acid hypochlorous solution in laboratory animal facilities, and we will also proceed with the validation of effects other than spraying. en-copyright= kn-copyright= en-aut-name=OnoTomoko en-aut-sei=Ono en-aut-mei=Tomoko kn-aut-name=小野朋子 kn-aut-sei=小野 kn-aut-mei=朋子 aut-affil-num=1 ORCID= en-aut-name=YamashitaKoji en-aut-sei=Yamashita en-aut-mei=Koji kn-aut-name=山下光治 kn-aut-sei=山下 kn-aut-mei=光治 aut-affil-num=2 ORCID= affil-num=1 en-affil=Research and Technology Development Division，HSP company kn-affil=株式会社エイチ・エス・ピー 研究開発部 affil-num=2 en-affil=Research and Technology Development Division，HSP company kn-affil=株式会社エイチ・エス・ピー 研究開発部 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=32 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Intracellular uptake of extracellular vesicles shed by bone marrow-derived macrophages stimulated with lactic acid bacteria in adipocyte and skeletal muscle cell line kn-title=乳酸菌を貪食したマクロファージが放出する細胞外小胞の脂肪細胞 および骨格筋細胞への取り込み en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TsurutaTakeshi en-aut-sei=Tsuruta en-aut-mei=Takeshi kn-aut-name=鶴田剛司 kn-aut-sei=鶴田 kn-aut-mei=剛司 aut-affil-num=1 ORCID= en-aut-name=ItoYohei en-aut-sei=Ito en-aut-mei=Yohei kn-aut-name=伊藤洋平 kn-aut-sei=伊藤 kn-aut-mei=洋平 aut-affil-num=2 ORCID= en-aut-name=NishinoNaoki en-aut-sei=Nishino en-aut-mei=Naoki kn-aut-name=西野直樹 kn-aut-sei=西野 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=Teresia Aluoch Muhomah en-aut-sei=Teresia Aluoch Muhomah en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatsumataEmiko en-aut-sei=Katsumata en-aut-mei=Emiko kn-aut-name=勝又恵実子 kn-aut-sei=勝又 kn-aut-mei=恵実子 aut-affil-num=5 ORCID= en-aut-name=SonoyamaKei en-aut-sei=Sonoyama en-aut-mei=Kei kn-aut-name=園山慶 kn-aut-sei=園山 kn-aut-mei=慶 aut-affil-num=6 ORCID= affil-num=1 en-affil=Okayama University Graduate School of Environmental and Life Science kn-affil=岡山大学大学院環境生命科学研究科 affil-num=2 en-affil=Okayama University Graduate School of Environmental and Life Science kn-affil=岡山大学大学院環境生命科学研究科 affil-num=3 en-affil=Okayama University Graduate School of Environmental and Life Science kn-affil=岡山大学大学院環境生命科学研究科 affil-num=4 en-affil=Okayama University Graduate School of Environmental and Life Science kn-affil=岡山大学大学院環境生命科学研究科 affil-num=5 en-affil=Okayama University Graduate School of Environmental and Life Science kn-affil=岡山大学大学院環境生命科学研究科 affil-num=6 en-affil=Hokkaido University, Research Faculty of Agriculture kn-affil=北海道大学大学院農学研究院 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=28 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Male sexual maturation of two Microtus species under laboratory conditions kn-title=飼育下におけるハタネズミ2 系統のオスの性成熟について en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is important to know the optimal timing of mating to produce laboratory animals efficiently and to ensure the preservation laboratory strains. To clarify the characteristics of the male sexual maturity of two laboratory Mictorus strains, namely the “Mar” and “MrosA” strains, which are derived from M. arvalis and M. levis, respectively, the testes and epididymes from 4-, 6-, 8- and 10 week-old males were weighed and compared. Although the tissue weights increased gradually with age in the Mar strain, in the MrosA strain, the weight of the testis increased markedly from 4 to weeks of age and that of the epididymis increased from 6 to 8 weeks of age. In addition, the spermatozoa concentrations in the cauda epididymis at 6, 8, and 10 weeks of age in were measured in each strain. The sperm concentration increased in the Mar strain at 8 weeks versus 6 weeks in the MrosA strain. From these results, it is clear that there are differences in the patterns of the increases in testis and epididymis weight and sperm concentration between the two strains. It was suggested that males of the MrosA strain attain sexual maturity earlier than those of the Mar strain. en-copyright= kn-copyright= en-aut-name=MatsumotoIbuki en-aut-sei=Matsumoto en-aut-mei=Ibuki kn-aut-name=松本息吹 kn-aut-sei=松本 kn-aut-mei=息吹 aut-affil-num=1 ORCID= en-aut-name=TakeshitaKeiryu en-aut-sei=Takeshita en-aut-mei=Keiryu kn-aut-name=竹下渓竜 kn-aut-sei=竹下 kn-aut-mei=渓竜 aut-affil-num=2 ORCID= en-aut-name=MekadaKazuyuki en-aut-sei=Mekada en-aut-mei=Kazuyuki kn-aut-name=目加田和之 kn-aut-sei=目加田 kn-aut-mei=和之 aut-affil-num=3 ORCID= affil-num=1 en-affil=Okayama University of Science kn-affil=岡山理科大学 affil-num=2 en-affil=Okayama University of Science kn-affil=岡山理科大学 affil-num=3 en-affil=Okayama University of Science kn-affil=岡山理科大学 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=21 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cytoskeletal elements in an acoelomorph worm, Praesagittifera naikaiensis kn-title=無腸動物Praesagittifera naikaiensis における細胞骨格要素 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Acoel flatworms can move in a variety of ways such as muscular and ciliary movements via cytoskeletal elements and their neural regulations. However, those locomotive mechanisms have not yet been fully elucidated. In this study, we examined the distribution of cytoskeletal elements including filamentous actin (F-actin) and tubulin, and the neuroanatomical organization in an acoelomorph worm, Praesagittifera naikaiensis (P. naikaiensis). Video microscopy revealed the elongation/contraction and the bending/rotation processes, and the ciliary gliding movement of P. naikaiensis. Histochemical and morphological analysis demonstrated that F-actin networks of inner longitudinal and outer circular muscle fibers were positioned along the entire surface of the body, and that the average distance between the circular muscle fibers in the contracted organism was decreased in the anterior region compared with that in the elongated organism. Electron microscopy showed dense bodies on the muscle cells of P. naikaiensis, which indicates that those muscle cells have the appearance of vertebrate smooth muscle cells. Immunohistochemical analysis revealed that ?-tubulin-positive signals on the ciliary microtubules had close contact with the F-actin network, and that neurite bundles labelled with anti dSap47 antibody as a neuronal marker run along the anterior-posterior body axis. These results indicate that the well-organized cytoskeletal elements and their neural control systems are preserved in P. naikaiensis, and that their mechanisms involved in those regulation systems are similar to those vertebrate systems. Further studies are needed to clarify the physiological mechanisms underlying the muscular and ciliary movements in P. naikaiensis. en-copyright= kn-copyright= en-aut-name=IkedaRisa en-aut-sei=Ikeda en-aut-mei=Risa kn-aut-name=池田理佐 kn-aut-sei=池田 kn-aut-mei=理佐 aut-affil-num=1 ORCID= en-aut-name=FujiwaraChiho en-aut-sei=Fujiwara en-aut-mei=Chiho kn-aut-name=藤原稚穂 kn-aut-sei=藤原 kn-aut-mei=稚穂 aut-affil-num=2 ORCID= en-aut-name=HamadaMayuko en-aut-sei=Hamada en-aut-mei=Mayuko kn-aut-name=濱田麻友子 kn-aut-sei=濱田 kn-aut-mei=麻友子 aut-affil-num=3 ORCID= en-aut-name=SakamotoTatsuya en-aut-sei=Sakamoto en-aut-mei=Tatsuya kn-aut-name=坂本竜哉 kn-aut-sei=坂本 kn-aut-mei=竜哉 aut-affil-num=4 ORCID= en-aut-name=SaitoNoboru en-aut-sei=Saito en-aut-mei=Noboru kn-aut-name=齋藤昇 kn-aut-sei=齋藤 kn-aut-mei=昇 aut-affil-num=5 ORCID= en-aut-name=AndoMotonori en-aut-sei=Ando en-aut-mei=Motonori kn-aut-name=安藤元紀 kn-aut-sei=安藤 kn-aut-mei=元紀 aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=3 en-affil=Ushimado Marine Institute, Faculty of Science, Okayama University kn-affil=岡山大学・理学部附属臨海実験所 affil-num=4 en-affil=Ushimado Marine Institute, Faculty of Science, Okayama University kn-affil=岡山大学・理学部附属臨海実験所 affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 affil-num=6 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=17 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Avian coccidiosis : Toward the understanding of pathophysiology in Eimeria tenella infection kn-title=鶏コクシジウム症：アイメリア・テネラ感染メカニズムの解明に向けて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Avian coccidiosis is most important entero-parasitic disease in the world. Eimeria parasite is causative agent of this disease. In Japan, this parasite species were widely spread and the positive rates are about 50 in layer and 70 % in broiler. The symptoms of coccidiosis are diarrhea, bloody excretion, weight loss, and die. Eimeria tenella is the most pathogenic protozoa. The sporozoites, infection form of this parasite, entry to epithelial cells around the crypt of cecum in early infection. After infection, parasites proliferate in epithelial cells, and form to sexual stage finally. However, we have less information about the pathophysiology, especially invasive mechanisms and infection route, by E. tenella infection. We have focused to analyze the invasive mechanism and route of this parasite because this phenomenon is first event to cause the pathophysiological changes in the infection. I would like to inform about Eimeria parasite and introduce our research in this paper. en-copyright= kn-copyright= en-aut-name=HatabuToshimitsu en-aut-sei=Hatabu en-aut-mei=Toshimitsu kn-aut-name=畑生俊光 kn-aut-sei=畑生 kn-aut-mei=俊光 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate school of Environmental and Life Sciences, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=10 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=What enables hibernation? : insights from a mammalian hibernator, Syrian hamster kn-title=冬眠する哺乳類シリアンハムスターに学ぶ、冬眠可能な生体状態とは？ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hibernation is an adaptive strategy for surviving during periods with little or no food availability, by profoundly reducing the metabolic rate and the core body temperature (Tb). Mammalian hibernators store fat extensively in white adipose tissues (WATs) during pre-hibernation period to prepare for hibernation. Thus, they undergo adaptive body remodelling in autumn, the pre-hibernation period, prior to hibernation, whereas little is known about the physiological and molecular mechanisms of the pre-hibernation remodelling. Syrian hamsters (Mesocricetus auratus) are facultative hibernators that can hibernate irrespective of seasons when exposed to prolonged short photoperiod and cold ambient temperature (SD-Cold) conditions. We found that before the initiation of hibernation, the body mass of Syrian hamsters decreased below a threshold, indicating that hibernation in this species depends on body condition. Global profiling of gene expression in various tissues of animals during the pre-hibernation period and hibernation period identified adaptive changes for hibernation at molecular level. Thus, Syrian hamsters as a model animal to study hibernation provide us a unique and convenient opportunity to analyse molecular and physiological mechanisms of adaptive pre-hibernation remodelling under a laboratory condition. en-copyright= kn-copyright= en-aut-name=YamaguchiYoshifumi en-aut-sei=Yamaguchi en-aut-mei=Yoshifumi kn-aut-name=山口良文 kn-aut-sei=山口 kn-aut-mei=良文 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Genetics, Graduate School of Pharmaceutical Science, University of Tokyo kn-affil=東京大学 大学院薬学系研究科 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=5 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Extracorporeal Excretion of Mercury from Mice Using Molybdenum Complex kn-title=生体内水銀の体外排泄に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Extracorporeal excretion of mercury by two molybdenum complexes was investigated using mice after injection of metallic mercury or mercuric ion. After injection of metallic mercury into mice, the mice that received the incomplete cubane-type sulfur-bridged nitrilotriacetato molybdenum (IV) complex ([Mo3S4(Hnta)3]2-, referred to as the NTA complex) had the highest mercury content in their urine on the first day, followed by L-cysteine solution and then water. On the other hand, after injection of mercuric ion, the urinary mercury excretion from the mice that received various concentrations of the incomplete cubane-type sulfur-bridged cysteinato molybdenum (V) complex ([Mo2O2S2(cys)2]2-, referred to as the CYS complex) showed a higher level than that of mice that received water (control group). The mercury content in the heart and lungs of the group that received the CYS complex solution decreased in comparison with that of the group that received the water. At the same time, the mercury level in the kidneys for the CYS complex solution group showed the tendency to increase relative to the group that received water. en-copyright= kn-copyright= en-aut-name=AikohHiromi en-aut-sei=Aikoh en-aut-mei=Hiromi kn-aut-name=愛甲博美 kn-aut-sei=愛甲 kn-aut-mei=博美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=2 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Transcription factor Runx3 in the mouse hypothalamo-pituitary-gonadal system kn-title=マウス視床下部・下垂体・生殖腺系における転写因子Runx3の役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Runx3 is a transcription factor that belongs to the Runx family. Female Runx3 knockout (Runx3???) mouse was anovulatory and infertile. Ovarian transplantation experiment suggested that lack of ovulation in Runx3??? mice was caused by alteration of gonadotropin secretion in Runx3??? mice. Cyp11a1 mRNA expression was less in Runx3??? mouse ovaries than in wt ones. Hypothalamic Gnrh1 mRNA was increased, and Kiss1 mRNA expression in the anteroventral periventricular nucleus was decreased, but Kisspeptin mRNA in the arcuate nucleus was increased in Runx3-/- mice. Pituitary Fshb mRNA levels were increased in Runx3??? mice. Cholesterol side-chain cleavage enzyme gene (Cyp11a1) expression was decreased in ovaries of Runx3??? mice. These findings suggest that anovulation in Runx3??? mice was partly due to the alterations in hypothalamus-pituitary-ovary system. Runx3 plays a key role in female reproduction through alteration of gonadotropin secretion. en-copyright= kn-copyright= en-aut-name=TakahashiSumio en-aut-sei=Takahashi en-aut-mei=Sumio kn-aut-name=高橋純夫 kn-aut-sei=高橋 kn-aut-mei=純夫 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil=岡山大学大学院自然科学研究科高次生物科学講座･生体統御学分野 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=1 end-page=1 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=会長あいさつ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name=国枝哲夫 kn-aut-sei=国枝 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=神経障害性疼痛に対する早期の持続末梢神経ブロックの効果について : ラットを用いた行動学的および免疫組織学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OnishiEriko en-aut-sei=Onishi en-aut-mei=Eriko kn-aut-name=大西梨恵子 kn-aut-sei=大西 kn-aut-mei=梨恵子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨治癒過程におけるビスフォスフォネート系製剤によるTリンパ球への影響の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakatsujiKazuki en-aut-sei=Nakatsuji en-aut-mei=Kazuki kn-aut-name=中辻和樹 kn-aut-sei=中辻 kn-aut-mei=和樹 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=真菌二次代謝産物である(+)-terreinがマウス骨髄由来マクロファージにおいてRANKL誘導性破骨細胞分化に及ぼす影響と標的分子の解明 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaSaki en-aut-sei=Nakagawa en-aut-mei=Saki kn-aut-name=中川沙紀 kn-aut-sei=中川 kn-aut-mei=沙紀 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=インクレチンによる卵巣ステロイド合成への影響とその機序の検討 kn-title=Incretins modulate progesterone biosynthesis by regulating bone morphogenetic protein activity in rat granulosa cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NishiyamaYuki en-aut-sei=Nishiyama en-aut-mei=Yuki kn-aut-name=西山悠紀 kn-aut-sei=西山 kn-aut-mei=悠紀 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=脳梗塞モデルマウスを用いた生体内酸化ストレスイメージングの経時的変化 kn-title=Time-dependent Change of In Vivo Optical Imaging of Oxidative Stress in a Mouse Stroke Model en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name=中野由美子 kn-aut-sei=中野 kn-aut-mei=由美子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=107 cd-vols= no-issue= article-no= start-page=19 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Non-surgical Transfer Method of Elongating Bovine Conceptus kn-title=ウシ伸長期胚の非外科的移植技術 en-subtitle= kn-subtitle= en-abstract= kn-abstract= 　The objectives of the present study were to establish a non-surgical transfer method for elongating bovine conceptuses and to combine this method with biopsy and sexing. Bovine conceptuses were recovered from donor cows on day 13-14 of the estrus cycle. In experiment 1, day 13 conceptuses were transferred to recipient cows using a standard day 7 embryo transfer (ET) method. The pregnancy rate of day 13 conceptus transfer (CT) is comparable to that of day 7 ET. In experiment 2, day 14 conceptuses were transferred using modified methods (balloon catheters or ET guns with modified sheaths). Using the standard ET method, no pregnancies were obtained;however, when balloon catheters or ET guns with modified sheaths were used, the pregnancy rates after CT were 48.0％ and 44.8％, respectively. In experiment 3, day 14 conceptuses were biopsied without a micromanipulator, sexed using the loop-mediated isothermal amplification (LAMP) method, and transferred to recipient cows. The pregnancy rate of biopsied conceptuses was 46.2％ and did not differ significantly from that of unbiopsied with conceptuses. Moreover, all pregnant cows transferred conceptuses following biopsy and sexing delivered calves with the expected sexes. These results suggested that the non-surgical bovine conceptus transfer (CT) method was comparable to day 7 ET, and that this technique enables biopsy and sexing without expensive equipment such as a micromanipulator or specialized skills. en-copyright= kn-copyright= en-aut-name=Faculty of Agriculture, Okayama University en-aut-sei=Faculty of Agriculture, Okayama University en-aut-mei= kn-aut-name=木村康二 kn-aut-sei=木村 kn-aut-mei=康二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=応用動物科学コース en-keyword=conceptus kn-keyword=conceptus en-keyword=biopsy kn-keyword=biopsy END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170929 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=熟成ニンニク抽出液に特徴的な水溶性イオウ化合物類の体内動態と薬物相互作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AmanoHirotaka en-aut-sei=Amano en-aut-mei=Hirotaka kn-aut-name=天野浩貴 kn-aut-sei=天野 kn-aut-mei=浩貴 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170929 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=小胞型グルタミン酸トランスポーター１スプライシングバリアント(VGLUT1v)の局在と機能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MoriyamaSatomi en-aut-sei=Moriyama en-aut-mei=Satomi kn-aut-name=森山理美 kn-aut-sei=森山 kn-aut-mei=理美 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170929 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=マウスにおいてパパインによるドナー膵島の移植前処理は全身免疫抑制剤の投与なしに同種異系膵島移植成績を向上させる kn-title=Pretreatment of donor islets with papain improves allograft survival without systemic immunosuppression in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KumanoKenjiro en-aut-sei=Kumano en-aut-mei=Kenjiro kn-aut-name=熊野健二郎 kn-aut-sei=熊野 kn-aut-mei=健二郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=65 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organization and Rules of the Association kn-title=組織・会則 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=60 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Member Directory kn-title=会員名簿 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=59 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=By-Low of membership fee and Notes of Contributors kn-title=会費に関する内規、会報投稿規程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=48 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=71th and 72th Meeting News, and the Secretary Meeting News kn-title=第71回、第72回研究会、理事会報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=40 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction to the activities of the Regional Associations for Laboratory Animal Science kn-title=地区研究会の活動紹介 en-subtitle= kn-subtitle= en-abstract= There are eleven Regional Associations for Laboratory Animal Science in Japan, and each of them conducts independent activities. The present paper introduces the activities of the Regional Associations in 2016 to promote information exchange and interaction among them, starting from those of the northernmost association. In the paper, honorifics for the staff of the office, lecturers, and people who provided us with information on topics have been omitted. For the details, please contact the office of each Regional Association. kn-abstract= わが国には現在11 の地区研究会があり、独自の活動が展開されています。本報では、各地区研究会の間での情報交換、交流などを意図して、平成28 年度の活動について北から順に紹介します。 なお、会長、事務局担当者及び講演者、話題提供者の方々のお名前は敬称を省略させていただきました。詳細な内容をご希望の方は各地区研究会の事務局にお問い合わせ下さい。 en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction of Laboratory Animal Facilities in the Life Science Research Center, Gifu University kn-title=岐阜大学生命科学総合研究支援センター動物実験施設の紹介 en-subtitle= kn-subtitle= en-abstract= kn-abstract= The facilities of laboratory animal within the Division of Animal Experiments, Life Science Research Center, Gifu University was established in April 2005. In order to gain reliable data from animal experiments, it is vital that the subjects' environment be stable and well-controlled. In addition, the safety impact to humans and bioethical rules must be considered when conducting animal experiments. We provide both the facilities necessary for such experiments as well as comprehensive support in the form of experiment program planning and subject care and maintenance. en-copyright= kn-copyright= en-aut-name=NikamiHideki en-aut-sei=Nikami en-aut-mei=Hideki kn-aut-name=二上英樹 kn-aut-sei=二上 kn-aut-mei=英樹 aut-affil-num=1 ORCID= affil-num=1 en-affil=Division of Animal Experiment, Life Science Research Center, Gifu University kn-affil=岐阜大学生命科学総合研究支援センター動物実験分野 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=31 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Identification of Marker Gene of Pars Tuberalis Morphogenesis in Chicken Embryo. The expression of Cytokine-like 1 and Gap junction protein alpha 5 in the pars tuberalis kn-title=下垂体隆起部の発生期に特異的に発現する遺伝子Cytokine-like 1,Gap junction protein alpha 5の同定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Adenohypophysis delivered from oral ectoderm consists of pars distalis (PD), pars intermedia and pars tuberalis (PT). The mechanisms of development of PD has been well studied, and the cell differentiation of PD has been well understood. However, the morphogenesis and the differentiation of PT are still unclear, and the gene expression during the PT development remains largely unknown. In this study, we explored the specifically expressing genes in PT during development and analyzed its spatiotemporal expressions pattern. Microarray analysis on laser-captured PT and PD tissues obtained from chicken embryos on embryonic day 10 (E10.0) showed high expressing genes, Cytokine-like 1 (CYTL1) and Gap junction protein alpha 5 (GJA5) in PT. A detail analysis of spatiotemporal expressions pattern during chick embryo development by in situ hybridization revealed that CYTL1 mRNA was first detected in lateral head ectoderm and ventral head ectoderm in E1.5. The CYTL1 expressions moved into Rathke’s pouch at E2.5, then it was localized in PT primordium and continuously expressed in PT primordium until E12.0. On the other hand, GJA5 mRNA was transiently detected in PT primordium from E6 to E14.0, while the expression was not detected in PD during development. These results suggested that these genes may be involved in the regulation mechanism of PT development and could be a useful marker in the PT development. en-copyright= kn-copyright= en-aut-name=AizawaSayaka en-aut-sei=Aizawa en-aut-mei=Sayaka kn-aut-name=相澤清香 kn-aut-sei=相澤 kn-aut-mei=清香 aut-affil-num=1 ORCID= en-aut-name=HigakiYuriko en-aut-sei=Higaki en-aut-mei=Yuriko kn-aut-name=檜垣佑理子 kn-aut-sei=檜垣 kn-aut-mei=佑理子 aut-affil-num=2 ORCID= en-aut-name=OgoshiMaho en-aut-sei=Ogoshi en-aut-mei=Maho kn-aut-name=御輿真穂 kn-aut-sei=御輿 kn-aut-mei=真穂 aut-affil-num=3 ORCID= en-aut-name=TakeuchiSakae en-aut-sei=Takeuchi en-aut-mei=Sakae kn-aut-name=竹内栄 kn-aut-sei=竹内 kn-aut-mei=栄 aut-affil-num=4 ORCID= en-aut-name=TakahashiSumio en-aut-sei=Takahashi en-aut-mei=Sumio kn-aut-name=高橋純夫 kn-aut-sei=高橋 kn-aut-mei=純夫 aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil=岡山大学大学院自然科学研究科 affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil=岡山大学大学院自然科学研究科 affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil=岡山大学大学院自然科学研究科 affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil=岡山大学大学院自然科学研究科高次生物科学講座･生体統御学分野 affil-num=5 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil=岡山大学大学院自然科学研究科高次生物科学講座･生体統御学分野 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=26 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Structure and function of tegmentum vasculosum in avian cochlea kn-title=鳥類内耳tegmentum vasculosum の構造と機能 en-subtitle= kn-subtitle= en-abstract= kn-abstract= In spite of the importance of endocochlear DC potential (EP) and the K+-rich endolymph for the avian cochlea, the structure and function of the tegmentum vasculosum (TV) has not yet been fully elucidated, compared with those of the stria vascularis in the mammalian cochlea. In this study, we examined structural analysis of the epithelial cells, gene expressions of Na+-K+-ATPase (Atp1A1) and Kir4.1 (Kcnj10), and protein localizations of Na+-K+-ATPase and Kir4.1, in the TV. Tight junctional structures were observed between epithelial dark cells and light cells in the TV. Both Atp1a1 and Kcnj10 genes were detected in the TV. In addition, immunopositive signals for both Na+-K+-ATPase and Kir4.1 were recognized in the TV. These results indicate that Na+-K+-ATPase and Kir4.1 play roles in maintaining the EP and high K+ concentration of the endolymph. Further studies are needed to clarify the physiological functions of the TV. This is the first report which demonstrates that gene and protein expression data contribute to the avian inner ear homeostasis. en-copyright= kn-copyright= en-aut-name=IkedaRisa en-aut-sei=Ikeda en-aut-mei=Risa kn-aut-name=池田理佐 kn-aut-sei=池田 kn-aut-mei=理佐 aut-affil-num=1 ORCID= en-aut-name=OtonoTsuyoshi en-aut-sei=Otono en-aut-mei=Tsuyoshi kn-aut-name=乙野剛史 kn-aut-sei=乙野 kn-aut-mei=剛史 aut-affil-num=2 ORCID= en-aut-name=IkedaNaoya en-aut-sei=Ikeda en-aut-mei=Naoya kn-aut-name=池田直矢 kn-aut-sei=池田 kn-aut-mei=直矢 aut-affil-num=3 ORCID= en-aut-name=SaitoNoboru en-aut-sei=Saito en-aut-mei=Noboru kn-aut-name=齋藤昇 kn-aut-sei=齋藤 kn-aut-mei=昇 aut-affil-num=4 ORCID= en-aut-name=AndoMotonori en-aut-sei=Ando en-aut-mei=Motonori kn-aut-name=安藤元紀 kn-aut-sei=安藤 kn-aut-mei=元紀 aut-affil-num=5 ORCID= affil-num=1 en-affil=Laboratory of Cell Physiology, Department of Science Education, Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 affil-num=2 en-affil=Laboratory of Cell Physiology, Department of Science Education, Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 affil-num=3 en-affil=Laboratory of Cell Physiology, Department of Science Education, Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 affil-num=4 en-affil=Laboratory of Animal Physiology and Pharmacology, Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科・動物機能開発学講座・動物生理学研究室 affil-num=5 en-affil=Laboratory of Cell Physiology, Department of Science Education, Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=22 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Taxonomic status of Aco strain derived from spiny mice kn-title=トゲマウスAco 系統の種の確定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Spiny mice are useful in regenerative research and as a model for precocial animals. In the present study, we investigated the taxonomic status of the Aco strain, which is derived from spiny mice of an unidentified species. Although this Aco strain has been tentatively considered A. cahirinus species, it was distinguished from this species based on conventional and G-banding chromosomal patterns of this strain. Subsequently, we determined the nucleotide sequence of the mitochondorial gene cytochrome b (Cyb) and constructed a molecular phylogenetic tree. We found that the Aco strain belongs to the same clade as A. dimidiatus. Based on this molecular analysis, we concluded that the Aco strain of spiny mice should be considered A. dimidiatus. en-copyright= kn-copyright= en-aut-name=MochidaHitomi en-aut-sei=Mochida en-aut-mei=Hitomi kn-aut-name=持田瞳 kn-aut-sei=持田 kn-aut-mei=瞳 aut-affil-num=1 ORCID= en-aut-name=MekadaKazuyuki en-aut-sei=Mekada en-aut-mei=Kazuyuki kn-aut-name=目加田和之 kn-aut-sei=目加田 kn-aut-mei=和之 aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Zoology, Faculty of Science, Okayama University of Science kn-affil=岡山理科大学 理学部 動物学科 affil-num=2 en-affil=Department of Zoology, Faculty of Science, Okayama University of Science kn-affil=岡山理科大学 理学部 動物学科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=18 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Inhibitory effects of caffeine on allergic rhinitis symptoms in mice kn-title=カフェインによるアレルギー性鼻炎の抑制効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= We examined the effects of caffeine treatment on ovalbumin- and histamine-induced rhinitis mouse models and on corticosterone and catecholamine levels in mouse plasma. Treatment with caffeine decreased sneezing and nasal rubbing in both models, but direct nasal administration had no effect. Plasma levels of corticosterone and catecholamine, which have known anti-allergy effects, were increased by caffeine treatment. The increases in corticosterone and catecholamine may be associated with the suppression of rhinitis symptoms. en-copyright= kn-copyright= en-aut-name=TsujimotoMadoka en-aut-sei=Tsujimoto en-aut-mei=Madoka kn-aut-name=辻本まどか kn-aut-sei=辻本 kn-aut-mei=まどか aut-affil-num=1 ORCID= en-aut-name=Saiki Akiko en-aut-sei=Saiki en-aut-mei= Akiko kn-aut-name=佐伯綾希子 kn-aut-sei=佐伯 kn-aut-mei=綾希子 aut-affil-num=2 ORCID= en-aut-name=SuzukiManami en-aut-sei=Suzuki en-aut-mei=Manami kn-aut-name=鈴木真奈美 kn-aut-sei=鈴木 kn-aut-mei=真奈美 aut-affil-num=3 ORCID= en-aut-name=ShiragaToshiyuki en-aut-sei=Shiraga en-aut-mei=Toshiyuki kn-aut-name=白神俊幸 kn-aut-sei=白神 kn-aut-mei=俊幸 aut-affil-num=4 ORCID= en-aut-name=SugimotoYukio en-aut-sei=Sugimoto en-aut-mei=Yukio kn-aut-name=杉本幸雄 kn-aut-sei=杉本 kn-aut-mei=幸雄 aut-affil-num=5 ORCID= en-aut-name=HayashiYasushi en-aut-sei=Hayashi en-aut-mei=Yasushi kn-aut-name=林泰資 kn-aut-sei=林 kn-aut-mei=泰資 aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 affil-num=2 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 affil-num=3 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 affil-num=4 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 affil-num=5 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 affil-num=6 en-affil=Graduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University kn-affil=ノートルダム清心女子大学大学院・人間生活学研究科・食品栄養学専攻 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=15 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Dissecting the hierarchy and lineage of mesenchymal stem cells by mouse genetics kn-title=遺伝子改変マウスを利用した生体内間葉系幹細胞の階層性の理解 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, including the mechanisms of tissue development and maintenance of tissue homeostasis, as well as disease development. It also has implications in the field of tissue regeneration for medical treatments and disease modeling for drug discovery using iPS technology. Mesenchymal stem cells are multipotent stem cell that can differentiate into various type of cells including osteoblasts, adipocytes, myocytes and chondrocytes. Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation. Runx2 deficiency in Prx1+-derived cells (Runx2prx1?/? mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1? cells. Our results suggest that osteoblast differentiation in vivo may begin at the Prx1+Sca1+ MSC stage with sequential progression to Prx1+Sca1?cells, then Osx+Prx1?Sca1? osteoblast precursors, which eventually form mature α1(I)-collagen+ osteoblasts. en-copyright= kn-copyright= en-aut-name=TakaradaTakeshi en-aut-sei=Takarada en-aut-mei=Takeshi kn-aut-name=宝田剛志 kn-aut-sei=宝田 kn-aut-mei=剛志 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Regenerative Science Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科組織機能修復学分野 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=11 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Contribution and progress of the gnotobiote technology in gut microbiome research kn-title=腸内フローラ研究におけるノトバイオ―ト技術の貢献と進展 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MoritaHidetoshi en-aut-sei=Morita en-aut-mei=Hidetoshi kn-aut-name=森田英利 kn-aut-sei=森田 kn-aut-mei=英利 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=8 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Overview and future perspectives of studies on the mechanisms underlying appetite regulation in chickens kn-title=ニワトリの食欲調節機構に関するこれまでの研究と今後の展望 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Broiler chickens eat more feed than layer chickens. As a result, broiler chickens grow faster than layer chickens. However, excessive accumulation of body fat in broiler chickens has been a serious problem in the poultry industry in recent decades. Therefore, the appetite regulatory system of chickens has been a focus of research among poultry scientists. Lines of evidence suggest that the physiological role of peripheral adiposity hormones, such as leptin and insulin, and gut hormones, such as ghrelin, are different between mammals and chickens. Thus, species specificity make it difficult to understand the mechanisms underlying the regulation of food intake in chickens. Here I provide an overview of recent findings in this field and future perspectives. en-copyright= kn-copyright= en-aut-name=HondaKazuhisa en-aut-sei=Honda en-aut-mei=Kazuhisa kn-aut-name=本田和久 kn-aut-sei=本田 kn-aut-mei=和久 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Agricultural Science, Kobe University kn-affil=神戸大学大学院農学研究科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=3 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pharmacokinetic analysis of drug absorption following nasal application to rats kn-title=ラットを用いた薬物の経鼻吸収実験と吸収動態解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= Since a drug applied to the nose in an in vivo physiologic condition is translocated to the gastrointestinal (GI) tract by mucociliary clearance (MC), the drug undergoes absorption both from the nasal cavity and from the GI tract. The detailed MC of the rat was examined, using inulin as a marker of the applied solution. Inulin disappeared monoexponentially from the nasal cavity, indicating that the MC can be assumed to follow first-order kinetics. In the proposed kinetic model, the fractional absorption of the drug following nasal application is predicted as the sum of fractional absorption from the nasal cavity and fractional absorption from the GI tract, both of which are estimated indirectly from the permeability to the Caco-2 monolayer. This kinetic model is the first estimation system for nasal drug absorption based on drug disposition after nasal application and is useful for the development of nasal dosage forms. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=古林呂之 kn-aut-sei=古林 kn-aut-mei=呂之 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Pharmaceutical Science, School of Pharmacy, Shujitsu University kn-affil=就実大学 薬学部 薬学科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=2 end-page=2 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Breeding and genetics of mutant strains and domestication of wildlife for laboratory animal science kn-title=ミュータント系実験動物育種と野生動物の実験動物化 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OdaSen-ichi en-aut-sei=Oda en-aut-mei=Sen-ichi kn-aut-name=織田銑一 kn-aut-sei=織田 kn-aut-mei=銑一 aut-affil-num=1 ORCID= affil-num=1 en-affil=Former Department of Zoology, Faculty of Science, Okayama University of Science kn-affil=元岡山理科大学理学部動物学科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=1 end-page=1 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A greeting from President of Okayama Association for Laboratory Animal Science kn-title=会長あいさつ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name=国枝哲夫 kn-aut-sei=国枝 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=抗糖尿病作用を有する亜鉛錯体の生体内挙動の可視化と生体内化学形態変化の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MunekaneMasayuki en-aut-sei=Munekane en-aut-mei=Masayuki kn-aut-name=宗兼将之 kn-aut-sei=宗兼 kn-aut-mei=将之 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=カイコモデルを用いた Porphyromonas gulae FimA の病原性機能の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YoshidaSho en-aut-sei=Yoshida en-aut-mei=Sho kn-aut-name=吉田翔 kn-aut-sei=吉田 kn-aut-mei=翔 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=マウス骨髄由来間葉系幹細胞の免疫調節能と年齢 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KunitomoMasayoshi en-aut-sei=Kunitomo en-aut-mei=Masayoshi kn-aut-name=國友雅義 kn-aut-sei=國友 kn-aut-mei=雅義 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of sensitivity to Cetuximab in HNC xenograft mouse models using molecular imaging kn-title=頭頸部癌マウスモデルを用いた分子イメージングによる抗癌剤セツキシマブ感受性の評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkadaShunsuke en-aut-sei=Okada en-aut-mei=Shunsuke kn-aut-name=岡田俊輔 kn-aut-sei=岡田 kn-aut-mei=俊輔 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The role of bone marrow-derived cells in ectopic bone regeneration in the GFP mouse bone marrow transplantation model kn-title=GFP骨髄移植マウスを用いた異所性骨形成における骨髄由来細胞の役割の解明 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=于淞 kn-aut-sei=于 kn-aut-mei=淞 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Role of GFP transplanted bone marrow derived cells into tumor stroma kn-title=GFP骨髄移植マウスを用いた腫瘍間質における骨髄由来細胞の動態と役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawaiHotaka en-aut-sei=Kawai en-aut-mei=Hotaka kn-aut-name=河合穂高 kn-aut-sei=河合 kn-aut-mei=穂高 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=1 article-no= start-page=9 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Does hydrogen-rich water really work? kn-title=水素水は怪しい水でしょうか？ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name=中尾篤典 kn-aut-sei=中尾 kn-aut-mei=篤典 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　救急医学 en-keyword=水素水 kn-keyword=水素水 en-keyword=抗酸化作用 kn-keyword=抗酸化作用 en-keyword=抗炎症作用 kn-keyword=抗炎症作用 en-keyword=臨床応用 kn-keyword=臨床応用 en-keyword=疑似科学 kn-keyword=疑似科学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=アルツハイマー病治療薬を指向した新規γ-セクレターゼ調節薬のデザインと合成ならびに生物学的評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakaiTakafumi en-aut-sei=Takai en-aut-mei=Takafumi kn-aut-name=高井隆文 kn-aut-sei=高井 kn-aut-mei=隆文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=76 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organization and Rules of the Association kn-title=組織・会則 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=71 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Member Directory kn-title=会員名簿 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=70 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=By-Low of membership fee and Notes of Contributors kn-title=会費に関する内規、会報投稿規程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=51 end-page=69 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=69th and 70th Meeting News, the 4th Symposium for Laboratory Animal Science, and the Secretary Meeting News kn-title=第69回、第70回研究会、第4回実験動物科学シンポジウム、理事会報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=42 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction to the activities of the Regional Associations for Laboratory Animal Science kn-title=地区研究会の活動紹介 en-subtitle= kn-subtitle= en-abstract=There are eleven Regional Associations for Laboratory Animal Science in Japan, and each of them conducts independent activities. The present paper introduces the activities of the Regional Associations in 2015 to promote information exchange and interaction among them, starting from those of the northernmost association. In the paper, honorifics for the staff of the office, lecturers, and people who provided us with information on topics have been omitted. For the details, please contact the office of each Regional Association. kn-abstract=わが国には現在11 の地区研究会があり、独自の活動が展開されています。本報では、各地区研究会の間での情報交換、交流などを意図して、平成27 年度の活動について北から順に紹介します。なお、会長、事務局担当者及び講演者、話題提供者の方々のお名前は敬称を省略させていただきました。詳細な内容をご希望の方は各地区研究会の事務局にお問い合わせ下さい。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=37 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=International Center of Veterinary Education and Research (iCOVER), Joint Faculty of Veterinary Medicine・Advanced Research Center for Laboratory Animal Science (ARCLAS), Yamaguchi University kn-title=山口大学獣医学国際教育研究センター・先端実験動物学研究施設 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Advanced Research Center for Laboratory Animal Science (ARCLAS) within International Center of Veterinary Education and Research (iCOVER), Joint Faculty of Veterinary Medicine, Yamaguchi University was established in January 2015. The purpose of ARCLAS is twofold: first, to provide care and management for laboratory animals in safe and adequate manner and, second, to prepare the education curricula for practical training for laboratory animal science. I will now show the outline of newly developed laboratory facilities, ARCLAS. en-copyright= kn-copyright= en-aut-name=KimuraTohru en-aut-sei=Kimura en-aut-mei=Tohru kn-aut-name=木村透 kn-aut-sei=木村 kn-aut-mei=透 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=山口大学共同獣医学部 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=33 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Confirmation test of education and training by e-learning system, for animal experiment researchers kn-title=e-learning システムを用いた動物実験教育訓練知識確認テスト en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Animal Care and Use Committee, Okayama University have conducted the lecture, which is provided to researchers and students, who use the mammalian, avian and/or reptilian species for research. To use these species for research and education in our university, researchers and students must need to attend this lecture, pass the examination on the e-learning system, “the Okayama University WebClass”.This system is useful in order to improve the effectiveness of education and training. en-copyright= kn-copyright= en-aut-name=YataNorio en-aut-sei=Yata en-aut-mei=Norio kn-aut-name=矢田範夫 kn-aut-sei=矢田 kn-aut-mei=範夫 aut-affil-num=1 ORCID= en-aut-name=UefujiChika en-aut-sei=Uefuji en-aut-mei=Chika kn-aut-name=上藤千佳 kn-aut-sei=上藤 kn-aut-mei=千佳 aut-affil-num=2 ORCID= en-aut-name=HirayamaHaruko en-aut-sei=Hirayama en-aut-mei=Haruko kn-aut-name=平山晴子 kn-aut-sei=平山 kn-aut-mei=晴子 aut-affil-num=3 ORCID= en-aut-name=MominokiKatsumi en-aut-sei=Mominoki en-aut-mei=Katsumi kn-aut-name=樅木勝巳 kn-aut-sei=樅木 kn-aut-mei=勝巳 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学自然生命科学研究支援センター affil-num=2 en-affil= kn-affil=岡山大学自然生命科学研究支援センター affil-num=3 en-affil= kn-affil=岡山大学自然生命科学研究支援センター affil-num=4 en-affil= kn-affil=岡山大学自然生命科学研究支援センター END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=28 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Comparison of promoters for transient gene expression in avian cells kn-title=鳥類細胞における一過性遺伝子発現のためのプロモーターの比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Genome editing technology by the CRISPR/Cas9, which was developed in 2012, is applicable in a variety of species. In birds, because the techniques of gene transfer and gene disruption has not been established, CRISPR/Cas9 method using adeno-associated virus (AAV) vector is the ideal combination as genome editing in vivo. However, in the use of AAV vectors, there is a problem to be solved that there is a limit on the size of the gene can be introduced. Therefore, it is important to minimize as much as possible the size of the gene. One strategy is to change the Cas9 gene into smaller ones, the other one is to minimize the promoter sequence. In this study, for the purpose of minimization of the promoter sequence to be introduced, the activities of the promoters to be general-purpose in mammals were verified in avian cells. CMV, CAG, and miCMV promoter shorten the CMV are all had sufficient activity in avian cells. en-copyright= kn-copyright= en-aut-name=KudoToshiyuki en-aut-sei=Kudo en-aut-mei=Toshiyuki kn-aut-name=工藤季之 kn-aut-sei=工藤 kn-aut-mei=季之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=就実大学 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=22 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Substrain differences of C57BL/6 mice kn-title=C57BL/6 マウスの亜系統差について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MekadaKazuyuki en-aut-sei=Mekada en-aut-mei=Kazuyuki kn-aut-name=目加田和之 kn-aut-sei=目加田 kn-aut-mei=和之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山理科大学 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=19 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Structure and expression of quail PBCF gene kn-title=ウズラPBCF 遺伝子の構造と発現 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KugimotoAyako en-aut-sei=Kugimoto en-aut-mei=Ayako kn-aut-name=釘本綾子 kn-aut-sei=釘本 kn-aut-mei=綾子 aut-affil-num=1 ORCID= en-aut-name=AizawaSayaka en-aut-sei=Aizawa en-aut-mei=Sayaka kn-aut-name=相澤清香 kn-aut-sei=相澤 kn-aut-mei=清香 aut-affil-num=2 ORCID= en-aut-name=OgoshiMaho en-aut-sei=Ogoshi en-aut-mei=Maho kn-aut-name=御輿真穂 kn-aut-sei=御輿 kn-aut-mei=真穂 aut-affil-num=3 ORCID= en-aut-name=TakahashiSumio en-aut-sei=Takahashi en-aut-mei=Sumio kn-aut-name=高橋純夫 kn-aut-sei=高橋 kn-aut-mei=純夫 aut-affil-num=4 ORCID= en-aut-name=TakeuchiSakae en-aut-sei=Takeuchi en-aut-mei=Sakae kn-aut-name=竹内栄 kn-aut-sei=竹内 kn-aut-mei=栄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=4 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=5 en-affil= kn-affil=岡山大学大学院自然科学研究科 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=12 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Animal Bio-Resources in the Department of Zoology, Faculty of Science, Okayama University of Science kn-title=岡山理科大学理学部動物学科における動物資源 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=JogaharaTakamichi en-aut-sei=Jogahara en-aut-mei=Takamichi kn-aut-name=城ヶ原貴通 kn-aut-sei=城ヶ原 kn-aut-mei=貴通 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山理科大学理学部動物学科 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=9 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Unique properties of mitochondria in mouse oocytes kn-title=マウス卵子におけるミトコンドリアの特性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WakaiTakuya en-aut-sei=Wakai en-aut-mei=Takuya kn-aut-name=若井拓哉 kn-aut-sei=若井 kn-aut-mei=拓哉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=5 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Conception of establishing a centralized animal facility for the institutional management to use the laboratory animals for research and education in Tsushima campus, Okayama University kn-title=岡山大学における動物実験に関わる機関管理体制の構築 ―非医療系キャンパスでの機関管理拠点として動物実験施設の整備コンセプトとその運用― en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been important for academic research institutions to properly use the laboratory animals for research and education, pursuant to the provisions of the Law, Care and Management Standards, and the Fundamental Guidelines concerning animal experiments and related activities. However, in the several faculties, which do not have the centralized animal facilities, it appears that using the animals are inconsistent with these ordinances. To avoid that the inconsistency becomes any problems, Okayama University has been established new centralized animal facility to propel the institutional management. This content presents our concept of establishing the facility to properly conduct researchers and students in the above-mentioned faculties. en-copyright= kn-copyright= en-aut-name=MominokiKatsumi en-aut-sei=Mominoki en-aut-mei=Katsumi kn-aut-name=樅木勝巳 kn-aut-sei=樅木 kn-aut-mei=勝巳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=自然生命科学研究支援センター END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=2 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fundamental guidelines for proper conduct ofanimal experiment and related activities in Academic research institutions kn-title=「研究機関等における動物実験等の実施に関する基本指針」について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KatsumataYasutaka en-aut-sei=Katsumata en-aut-mei=Yasutaka kn-aut-name=勝股靖貴 kn-aut-sei=勝股 kn-aut-mei=靖貴 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=文部科学省研究振興局ライフサイエンス課 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=1 end-page=1 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Agreeting from President of Okayama Association for Laboratory Animal science kn-title=会長あいさつ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name=国枝哲夫 kn-aut-sei=国枝 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Paclitaxel内封ポリマーナノ粒子製剤の薬物放出特性の最適化ならびに光増感剤内封ポリマーナノ粒子製剤を用いた光誘発型の腫瘍内血管透過性亢進技術の確立に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ArakiTomoya en-aut-sei=Araki en-aut-mei=Tomoya kn-aut-name=荒木知哉 kn-aut-sei=荒木 kn-aut-mei=知哉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨粗鬆症モデルマウスにおけるビスフォスフォネート系製剤および副甲状腺ホルモン製剤のTリンパ球分画への影響およびその関連因子の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuiYuichi en-aut-sei=Matsui en-aut-mei=Yuichi kn-aut-name=松井裕一 kn-aut-sei=松井 kn-aut-mei=裕一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=末梢神経損傷後の侵害受容1次ニューロンの収斂投射 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KishimotoNoriko en-aut-sei=Kishimoto en-aut-mei=Noriko kn-aut-name=岸本宜子 kn-aut-sei=岸本 kn-aut-mei=宜子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=2型糖尿病薬メトホルミンの制御性T細胞抑制による抗腫瘍効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KunisadaYuki en-aut-sei=Kunisada en-aut-mei=Yuki kn-aut-name=國定勇希 kn-aut-sei=國定 kn-aut-mei=勇希 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ゾレドロン酸が歯周炎に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IdeguchiHidetaka en-aut-sei=Ideguchi en-aut-mei=Hidetaka kn-aut-name=井手口英隆 kn-aut-sei=井手口 kn-aut-mei=英隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=33 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ARO：Academic Research Organization kn-title=ARO 体制整備 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ImamuraHisao en-aut-sei=Imamura en-aut-mei=Hisao kn-aut-name=今村久雄 kn-aut-sei=今村 kn-aut-mei=久雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　新医療創造MOT 講座 en-keyword=ARO kn-keyword=ARO en-keyword=アカデミアネットワーク kn-keyword=アカデミアネットワーク en-keyword=バイオバンク kn-keyword=バイオバンク en-keyword=シーズ開発 kn-keyword=シーズ開発 en-keyword=医療機器開発 kn-keyword=医療機器開発 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue= article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Identification of commensal bacteria coated with secretory immunoglobulin A kn-title=分泌型免疫グロブリンＡが認識する 腸内細菌種の同定 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A part of commensal intestinal bacteria in mammal including human, mouse, bovine and pig are coated with secretory immunoglobulin A (S?IgA). It has been suggested from our previous research that S?IgA coating of commensal bacteria occur in bacterial group specific manner in human and mouse intestine. Thus, identification of S?IgA?coated bacterial genera/species would certainly help to elucidate the interaction between S?IgA and commensal intestinal bacteria. However, the method to identify the genera/species of S?IgA?coated bacteria has not been established. To identify S?IgA?coated bacterial composition, we developed the method combining immunohistochemical detection of S?IgA and subsequent 16S rRNA targeted fluorescence in situ hybridization (FISH) analysis. Furthermore, human and mice fecal S?IgA coated bacterial composition was evaluated by this newly developed method with ten frequently?used FISH probes. Fecal S?IgA?coated bacterial composition was successfully analyzed with this method and this analysis suggested that Enterobacteriaceae was preferably coated with S?IgA whereas Bacteroides/Prevotella and Lactobacillus/ Enterococcus groups seemed to be poorly coated with S?IgA. This method will be applied to confirm whether interaction between S?IgA and commensal intestinal bacteria relate to symptom of inflammatory bowel diseases. en-copyright= kn-copyright= en-aut-name=TsurutaTakeshi en-aut-sei=Tsuruta en-aut-mei=Takeshi kn-aut-name=鶴田剛司 kn-aut-sei=鶴田 kn-aut-mei=剛司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学農学部 en-keyword=Secretory immunoglobulin A kn-keyword=Secretory immunoglobulin A en-keyword=commensal intestinal bacteria kn-keyword=commensal intestinal bacteria en-keyword=fluorescence in situ hybridization kn-keyword=fluorescence in situ hybridization END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=12 article-no= start-page=2065 end-page=2073 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of propolis on insulin resistance in fructose-drinking rats kn-title=フルクトース負荷インスリン抵抗性モデル(ラット)におけるPropolisによるインスリン抵抗性改善作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Propolis, a honeybee product, contains a variety of biologically active substances. The present study was designed to investigate the effects of propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), body weight, and systolic blood pressure but not blood glucose levels, when compared with control rats. Brazilian propolis extract (100 and 300mg/kg, p. o.) treatment for 8 weeks significantly decreased the plasma level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose and total cholesterol levels, and tended to decrease systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, propolis treatment resulted in a significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS; 8Hz) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, propolis treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that propolis could be an effective functional food to prevent the development of insulin resistance. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=TakatoriShingo en-aut-sei=Takatori en-aut-mei=Shingo kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=2 ORCID= en-aut-name=KoayamaToshihiro en-aut-sei=Koayama en-aut-mei=Toshihiro kn-aut-name=小山敏広 kn-aut-sei=小山 kn-aut-mei=敏広 aut-affil-num=3 ORCID= en-aut-name=GodaMitsuhiro en-aut-sei=Goda en-aut-mei=Mitsuhiro kn-aut-name=合田光寛 kn-aut-sei=合田 kn-aut-mei=光寛 aut-affil-num=4 ORCID= en-aut-name=IwataniYukiko en-aut-sei=Iwatani en-aut-mei=Yukiko kn-aut-name=岩谷有希子 kn-aut-sei=岩谷 kn-aut-mei=有希子 aut-affil-num=5 ORCID= en-aut-name=DoiShima en-aut-sei=Doi en-aut-mei=Shima kn-aut-name=土井志真 kn-aut-sei=土井 kn-aut-mei=志真 aut-affil-num=6 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=日本新薬創薬研究所 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=propolis kn-keyword=propolis en-keyword=fructose-drinking rat kn-keyword=fructose-drinking rat en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=periarterial nerve function kn-keyword=periarterial nerve function END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=6 article-no= start-page=833 end-page=840 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats kn-title=Propolis 長期投与による Otsuka Long-Evans Tokushima Fatty (OLETF) ラットの インスリン抵抗性改善作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=FujiwaraHiroki en-aut-sei=Fujiwara en-aut-mei=Hiroki kn-aut-name=藤原弘喜 kn-aut-sei=藤原 kn-aut-mei=弘喜 aut-affil-num=2 ORCID= en-aut-name=HosodaMiho en-aut-sei=Hosoda en-aut-mei=Miho kn-aut-name=細田美穂 kn-aut-sei=細田 kn-aut-mei=美穂 aut-affil-num=3 ORCID= en-aut-name=HinoHayato en-aut-sei=Hino en-aut-mei=Hayato kn-aut-name=日野隼人 kn-aut-sei=日野 kn-aut-mei=隼人 aut-affil-num=4 ORCID= en-aut-name=HiraiKazuhiro en-aut-sei=Hirai en-aut-mei=Kazuhiro kn-aut-name=平井和浩 kn-aut-sei=平井 kn-aut-mei=和浩 aut-affil-num=5 ORCID= en-aut-name=OkamotoKazuaki en-aut-sei=Okamoto en-aut-mei=Kazuaki kn-aut-name=岡本和明 kn-aut-sei=岡本 kn-aut-mei=和明 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=金? kn-aut-sei=金 kn-aut-mei=? aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高木志真 kn-aut-sei=高木 kn-aut-mei=志真 aut-affil-num=9 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=8 en-affil= kn-affil=日本新薬株式会社創薬研究所 affil-num=9 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=propolis kn-keyword=propolis en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=Otsuka Long-Evans Tokushima Fatty rat kn-keyword=Otsuka Long-Evans Tokushima Fatty rat en-keyword=periarterial nerve function kn-keyword=periarterial nerve function en-keyword=mesenteric vascular bed kn-keyword=mesenteric vascular bed END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=96 end-page=97 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organization and Rules of the Association kn-title=組織・会則 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=91 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Member Directory kn-title=会員名簿 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=90 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=By-Low of membership fee and Notes of Contributors kn-title=会費に関する内規、会報投稿規程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=74 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=67th and 68th Meeting News, Public Symposium and the Secretary Meeting News kn-title=第67回、第68 回研究会、公開シンポジウム、理事会報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=72 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Symposium on Laboratory Animal Science kn-title=実験動物科学シンポジウム en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=64 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction of the activity in the Regional Association for Laboratory Animal Science kn-title=地区研究会の活動紹介 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=59 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Institute of Laboratory Animal Research, Center for Animal Research and Education, Nagoya University kn-title=名古屋大学動物実験支援センター東山動物実験施設 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Institute of Laboratory Animal Research（ILAR）within the Center for Animal Research and Education (CARE), Nagoya University was established in July 2013. The aim of ILAR is to provide care for laboratory animals in safe and sanitary manner that enables researchers in the Nagoya University Higashiyama Campus to conduct proper experiments. We will now give an outline and introduce the characteristics of the new ILAR. en-copyright= kn-copyright= en-aut-name=ItohMariko en-aut-sei=Itoh en-aut-mei=Mariko kn-aut-name=伊藤麻里子 kn-aut-sei=伊藤 kn-aut-mei=麻里子 aut-affil-num=1 ORCID= en-aut-name=InagakiHideaki en-aut-sei=Inagaki en-aut-mei=Hideaki kn-aut-name=稲垣秀晃 kn-aut-sei=稲垣 kn-aut-mei=秀晃 aut-affil-num=2 ORCID= en-aut-name=MoriRarami en-aut-sei=Mori en-aut-mei=Rarami kn-aut-name=森ララミ kn-aut-sei=森 kn-aut-mei=ララミ aut-affil-num=3 ORCID= en-aut-name=TodaMayumi en-aut-sei=Toda en-aut-mei=Mayumi kn-aut-name=戸田真弓 kn-aut-sei=戸田 kn-aut-mei=真弓 aut-affil-num=4 ORCID= en-aut-name=AonoShuichi en-aut-sei=Aono en-aut-mei=Shuichi kn-aut-name=青野修一 kn-aut-sei=青野 kn-aut-mei=修一 aut-affil-num=5 ORCID= en-aut-name=SatoJun en-aut-sei=Sato en-aut-mei=Jun kn-aut-name=佐藤純 kn-aut-sei=佐藤 kn-aut-mei=純 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=名古屋大学動物実験支援センター東山動物実験施設 affil-num=2 en-affil= kn-affil=名古屋大学動物実験支援センター東山動物実験施設 affil-num=3 en-affil= kn-affil=岡山大学名古屋大学動物実験支援センター東山動物実験施設大学院医歯薬学総合研究科・分子医化学分野 affil-num=4 en-affil= kn-affil=名古屋大学動物実験支援センター東山動物実験施設 affil-num=5 en-affil= kn-affil=名古屋大学動物実験支援センター東山動物実験施設 affil-num=6 en-affil= kn-affil=名古屋大学動物実験支援センター東山動物実験施設 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=55 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunological identification of H+-coupled myo-inositol cotransporter in the lateral wall of the cochlea duct kn-title=蝸牛管側壁におけるミオイノシトール輸送体タンパク質の発現 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamajiMayumi en-aut-sei=Yamaji en-aut-mei=Mayumi kn-aut-name=山地真裕美 kn-aut-sei=山地 kn-aut-mei=真裕美 aut-affil-num=1 ORCID= en-aut-name=InoueRisa en-aut-sei=Inoue en-aut-mei=Risa kn-aut-name=井上理佐 kn-aut-sei=井上 kn-aut-mei=理佐 aut-affil-num=2 ORCID= en-aut-name=EdamatsuMidori en-aut-sei=Edamatsu en-aut-mei=Midori kn-aut-name=枝松緑 kn-aut-sei=枝松 kn-aut-mei=緑 aut-affil-num=3 ORCID= en-aut-name=AndoMotonori en-aut-sei=Ando en-aut-mei=Motonori kn-aut-name=安藤元紀 kn-aut-sei=安藤 kn-aut-mei=元紀 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 affil-num=2 en-affil= kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科・分子医化学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院教育学研究科・理科教育講座・細胞生理学研究室 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=50 end-page=54 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The practice of "animal experimental science" education that broaden student perspectives kn-title=視野の拡大を取り入れた「動物実験学」教育の試み en-subtitle= kn-subtitle= en-abstract=When they first enroll, most university students have a negative view of animal experiments. To provide a more accurate and balanced understanding, we have introduced "animal experimental science" education that aims to broaden perspectives. In addition to conventional animal experiments in medicine and biotechnology, we have also introduced the concept of experimentation in the field of animal nursing, in which the role of the companion animal is studied. In the lower grades, students have little information and tend to assume that all animal experiments are cruel. They are therefore very critical of animal experiments. In the higher grades, students take part in animal experiments. By appreciating the need for such experiments, our students became less critical. As graduation thesis students, many students choose to undertake animal experiments, if a scientific challenge requires it. Introducing the concepts of “laboratory animals” and “animal experiments” at the right educational stage leads students to a better understanding of animal experimentation. Through this process, the students’ reluctant acceptance can be changed to acceptance with a positive attitude. kn-abstract=入学時に動物実験に対し悪いイメージを持っている学生は少なくない。倉敷芸術科学大学生命科学部動物生命科学科では動物実験に対する正しい理解のため、医学およびバイオ分野における従来の動物実験の考え方のみならず、家庭動物を学びの対象とする動物看護分野における動物実験の考え方を取り入れることで、視点の拡大を目指す動物実験学を導入している。動物実験についての情報が少ない低学年では、「動物実験は残酷である」という部分に視点が集中し批判的な意見をもっている。しかしながら、学年が上がっていく過程で自身が動物実験を実施し、その必要性を実感する経験を繰り返すことで、動物実験を単に批判することはなくなっていく。4 年生では卒業研究における課題に科学的アプローチするために動物実験が必要な場合、多くの学生が動物実験の実施を前向きに選択するようにまでなる。学生の学びの対象に即した実験動物や動物実験の定義を教育に導入することで、動物実験への正しい理解へ繋がり、消極的容認が容認や肯定的態度へと変化していくと考えられる。 en-copyright= kn-copyright= en-aut-name=FurumotoKayo en-aut-sei=Furumoto en-aut-mei=Kayo kn-aut-name=古本佳代 kn-aut-sei=古本 kn-aut-mei=佳代 aut-affil-num=1 ORCID= en-aut-name=FurukawaToshinori en-aut-sei=Furukawa en-aut-mei=Toshinori kn-aut-name=古川敏紀 kn-aut-sei=古川 kn-aut-mei=敏紀 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=倉敷芸術科学大学 生命科学部 動物生命科学科 affil-num=2 en-affil= kn-affil=倉敷芸術科学大学 生命科学部 動物生命科学科 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=40 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practice of the 3Rs in Practical Training Using Animals -Preliminary training for the care, handling, injection and dissection of mice and rats- kn-title=実験動物を用いる実習における3Rs 実践の試み −マウス、ラットの飼育、保定、注射、解剖に向けての予備トレーニング− en-subtitle= kn-subtitle= en-abstract=In order to improve animal welfare through practical training in laboratory animal techniques at Hiroshima Animal Care College, we have been searching for ways to reduce animal suffering caused by such practical training. Students in the Animal Management Department learn to use animals in the practicum of laboratory animal science in their third year. In order to practice the 3Rs (Reduction, Replacement, and Refinement), we have introduced preliminary training before the students work with live animals. Specifically, the following five practices are introduced: 1. Practice of handling cages 2. Practice of controlling fine manipulation by pinching elastic balls and their own skin 3. Practice of sewing a dust cloth by hand, to learn how to handle sharp instruments 4. Practice of injecting chicken wing tips to learn how to inject animals 5. Practice of dissection techniques using thin pastry, chicken skin, and chicken wing tips We have not objectively verified whether these efforts are effective to reduce animal suffering. However, subjectively, we have observed some positive effects on the students. The primary object of this training is to reduce animal suffering. Furthermore, it may promote the psychological preparation of students who will be using live laboratory animals. Currently, training courses for animal technicians and animal nurses are taught at colleges or universities. From the viewpoints of ethics and animal welfare, it is necessary to refine the practical training program to work with live animals. We report our preliminary training as part of the program. kn-abstract=広島アニマルケア専門学校では、動物看護コース3 年課程（動物看護師志望者と実験動物技術者志望者が混 在）の3 年次に実施する実験動物学実習に際して、動物福祉の観点から動物に与える苦痛を可能な限り少なく できる実施法を模索してきた。実際に生きた動物を用いる実習を行う前に、いくつかの予備トレーニングを取 り入れた3Rs 実践の試みである。具体的には、ケージ取り扱い練習、先鋭器具取り扱い練習のための雑巾縫 製、保定練習を目的とした軟質ボールによる手指トレーニング、自身の皮膚摘まみ練習、鉛筆や鶏手羽先を用 いた注射器具使用練習、そして餃子の皮、鶏皮、鶏手羽先を用いた解剖器具使用練習などである。これらの取 り組みそれぞれが、果たして効果的であるかどうか検証できているわけではないが、学生の取り組みを間近で 観察した立場から、感覚的には効果を実感している。また、予備トレーニングは、動物に与える苦痛を軽減す ることを最大の目標とするものであるが、一方で、動物を用いた実習に臨む学生の心理的準備を促す効果もあ るように感じている。実験動物技術者や動物看護師養成課程、コースが、大学や専門学校に設けられ、そこに 多くの学生が学んでいる現在、動物を用いた実習のプログラムを動物実験倫理・動物福祉の観点からさらに洗 練させることが望まれる。そのプログラムの一部として、われわれの予備トレーニングの取り組みを紹介した。 en-copyright= kn-copyright= en-aut-name=UsudaToshiki en-aut-sei=Usuda en-aut-mei=Toshiki kn-aut-name=臼田俊樹 kn-aut-sei=臼田 kn-aut-mei=俊樹 aut-affil-num=1 ORCID= en-aut-name=FurumotoKayo en-aut-sei=Furumoto en-aut-mei=Kayo kn-aut-name=古本佳代 kn-aut-sei=古本 kn-aut-mei=佳代 aut-affil-num=2 ORCID= en-aut-name=KitaMegumu en-aut-sei=Kita en-aut-mei=Megumu kn-aut-name=北ｺ kn-aut-sei=北 kn-aut-mei=ｺ aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=広島アニマルケア専門学校動物看護コース affil-num=2 en-affil= kn-affil=広島アニマルケア専門学校動物看護コース affil-num=3 en-affil= kn-affil=倉敷芸術科学大学動物生命科学科 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=37 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of Kallikrein expression in the mouse endometrium kn-title=マウス子宮内膜細胞におけるKallikrein の発現制御の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TokumoriMegumi en-aut-sei=Tokumori en-aut-mei=Megumi kn-aut-name=徳森萌美 kn-aut-sei=徳森 kn-aut-mei=萌美 aut-affil-num=1 ORCID= en-aut-name=OgoshiMaho en-aut-sei=Ogoshi en-aut-mei=Maho kn-aut-name=御輿真穂 kn-aut-sei=御輿 kn-aut-mei=真穂 aut-affil-num=2 ORCID= en-aut-name=TakeuchiSakae en-aut-sei=Takeuchi en-aut-mei=Sakae kn-aut-name=竹内栄 kn-aut-sei=竹内 kn-aut-mei=栄 aut-affil-num=3 ORCID= en-aut-name=TakahashiSumio en-aut-sei=Takahashi en-aut-mei=Sumio kn-aut-name=高橋純夫 kn-aut-sei=高橋 kn-aut-mei=純夫 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科生体統御学グループ affil-num=2 en-affil= kn-affil=岡山大学大学院自然科学研究科生体統御学グループ affil-num=3 en-affil= kn-affil=岡山大学大学院自然科学研究科生体統御学グループ affil-num=4 en-affil= kn-affil=岡山大学大学院自然科学研究科生体統御学グループ END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=33 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Environmental Disinfection by Hypochlorous Acid Solution kn-title=次亜塩素酸水溶液による環境消毒について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Weak Acid Hypochlorous Solution (WAHS) has been used for disinfection of foods (meats, vegetables etc.), and for environmental disinfection in the Retirement homes, Hospitals and Laboratory Animal facilities. We will introduce here some of environmental disinfection tests. 1) To study whether WAHS is available or not for blood blot inoculated by Acinetobacter baumannii on the plate comparing with Sodium Hypochlorite. 2) Comparison of Ethanol and WAHS on the floor and handrail. 3) To study efficacy of shallowly dipping by WAHS on wagon caster inoculated by Staphylococcus aureus. The results are: 1) It was observed that WAHS had an efficacy equal to Hypochlorite with lower concentration in the blood test, but in case that the adhesion amount of blood was larger, much higher concentration or adding physical removal was needed. 2) Ethanol and WAHS had Equivalent efficacy on the test of floor and handrail. 3) It was suggested that shallowly dipping by WAHS was available for disinfection of wagon caster. We hope to proceed to confirm how to use WAHS for environmental disinfection. en-copyright= kn-copyright= en-aut-name=YamashitaKoji en-aut-sei=Yamashita en-aut-mei=Koji kn-aut-name=山下光治 kn-aut-sei=山下 kn-aut-mei=光治 aut-affil-num=1 ORCID= en-aut-name=HamamotoYuji en-aut-sei=Hamamoto en-aut-mei=Yuji kn-aut-name=濱本裕司 kn-aut-sei=濱本 kn-aut-mei=裕司 aut-affil-num=2 ORCID= en-aut-name=YasudaYuto en-aut-sei=Yasuda en-aut-mei=Yuto kn-aut-name=安田悠人 kn-aut-sei=安田 kn-aut-mei=悠人 aut-affil-num=3 ORCID= en-aut-name=OnoTomoko en-aut-sei=Ono en-aut-mei=Tomoko kn-aut-name=小野朋子 kn-aut-sei=小野 kn-aut-mei=朋子 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=株式会社 エイチ・エス・ピー affil-num=2 en-affil= kn-affil=株式会社 エイチ・エス・ピー affil-num=3 en-affil= kn-affil=株式会社 エイチ・エス・ピー affil-num=4 en-affil= kn-affil=株式会社 エイチ・エス・ピー END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=11 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Zebrafish swim left to right and prefer an inverted triangle rather than a circle innately without perceptual learning kn-title=ゼブラフィシュは知覚学習以前に反時計回りに左から右へ （L→R）泳ぎ、円形を避け倒立三角形に近づく en-subtitle= kn-subtitle= en-abstract= kn-abstract=The following results were obtained thorough induction and deduction by four experiments on the early experience controlled zebrafish 4 males and 4 females using 30-30-40 milliseconds behavior analysis system. [1] It was found zebrafish perform two kind of movement. The first is high speed anticlockwise (L→R) spiral circular swimming usig right hemisphere⇔left -visual field. The second is relatively slowly clock (L←R) willing large elliptic swimming usig left hemisphere⇔right-visual field. If we observe from the front of the tank, as DNA they almost always swim L→R basing probably on the rotation and revolution of the earth (Experiment 1). [2] In spite of the innate L→R swimming tendency, zebrafish prefer the visual black inverted triangle side presented to the circle with the same peripheral length. They avoid circle and go to the triangle in group following the leader without perceptual learning irrespective of the position （Experiment 1,2,3,4）。 [3] In such a way, an inverted triangle and a circle are psychophysiologically quite different geometrical configurations. en-copyright= kn-copyright= en-aut-name=MittaniKeiichi en-aut-sei=Mittani en-aut-mei=Keiichi kn-aut-name=三谷惠一 kn-aut-sei=三谷 kn-aut-mei=惠一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=環太平洋大学 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=8 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Secreted Frizzled-related protein 1 regulates the progression of renal fibrosis in a mouse model of obstructive nephropathy kn-title=Sfrp1 遺伝子は急性腎不全において腎線維化の進行を制御している en-subtitle= kn-subtitle= en-abstract= kn-abstract=Renal fibrosis is responsible for progressive renal diseases that cause chronic renal failure. Secreted Frizzled-related protein 1 (Sfrp1) is highly expressed in kidney, although little is known about connection between the protein and renal diseases. Here we focused on Sfrp1 to investigate its roles in renal fibrosis using a mouse model of unilateral ureteral obstruction (UUO). In wild-type mice, the expression of Sfrp1 protein was markedly increased after UUO. The kidneys from Sfrp1 knockout mice showed significant increase in expression of myofibrobast markers, alpha-smooth muscle actin (?SMA). Sfrp1 deficiency also increased protein levels of the fibroblast genes, Vimentin, and decreased those of the epithelial genes, E-cadherin, indicated that enhanced epithelial-to-mesenchymal transition (EMT). There was no difference in the levels of canonical Wnt signaling; rather the levels of phosphorylated c-Jun and JNK were more increased in the Sfrp1-/- obstructed kidney. Moreover, the apoptotic cell population was significantly elevated in the obstructed kidneys from Sfrp1-/- mice following UUO, but was slightly increased in those from wild-type mice. These results indicate that Sfrp1 is required for inhibition of renal damage through non-canonical Wnt/PCP pathway. en-copyright= kn-copyright= en-aut-name=MatsuyamaMakoto en-aut-sei=Matsuyama en-aut-mei=Makoto kn-aut-name=松山誠 kn-aut-sei=松山 kn-aut-mei=誠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=重井医学研究所分子遺伝部門 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=4 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Avian sex determination and aromatase gene kn-title=鳥類の性決定とアロマターゼ遺伝子 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sex is the most important exchange method of the genetic information in eukaryotes. Sex determination mechanism is varied depending on the species, however, sex differentiation mechanism in vertebrates are basically similar. Sex determination of birds is controlled by the sex chromosomes and their sexual differentiation are critically controlled by estrogen. Because estrogen is biosynthesized by aromatase, it is possible to find the sex-determining gene of birds by analyzing the transcriptional regulatory mechanism. While there have been conducting research on the basis of this concept, the mechanism has not yet been fully elucidated. On the other hand, DMRT1 gene has been cloned as a strong candidate in the sex-determining gene of birds. Analysis of cascade leading to the aromatase gene from DMRT1 gene is an important issue in the future. en-copyright= kn-copyright= en-aut-name=KudoToshiyuki en-aut-sei=Kudo en-aut-mei=Toshiyuki kn-aut-name=工藤季之 kn-aut-sei=工藤 kn-aut-mei=季之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=就実大学薬学部薬学科 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=2 end-page=3 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the molecular evolution (affinity maturation) of antibodies: unexpected encounter kn-title=抗体の分子進化（親和性成熟）の研究： 面白い結果は思いがけなく訪れる en-subtitle= kn-subtitle= en-abstract= kn-abstract=Antibodies are unique proteins in that they improve their affinity for antigens during antibody responses. This process termed “affinity maturation” is the result of random hypermutation of immunoglobulin genes in B cells followed by selection of the clones that acquired high-affinity antibodies. However, what mechanisms are responsible for the induction of hypermutation and the subsequent B cell selection in germinal centers has remained unknown in many respects. I would like to talk about our long-lasting studies on these immunologic mechanisms focusing on the functional role of follicular dendritic cells en-copyright= kn-copyright= en-aut-name=OhmoriHitoshi en-aut-sei=Ohmori en-aut-mei=Hitoshi kn-aut-name=大森斉 kn-aut-sei=大森 kn-aut-mei=斉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=1 end-page=1 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A greeting from President of Okayama Association for Laboratory Animal Science kn-title=会長あいさつ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name=国枝哲夫 kn-aut-sei=国枝 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=長波長紫外線（UVA）によるDNA傷害と突然変異誘発機構の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=樊星 kn-aut-sei=樊 kn-aut-mei=星 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=咬合支持の有無が記憶学習能と酸化ストレスに及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyazakiTakako en-aut-sei=Miyazaki en-aut-mei=Takako kn-aut-name=宮ｱ貴子 kn-aut-sei=宮ｱ kn-aut-mei=貴子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=食餌性状の違いはMyh遺伝子群の発現を変化させマウス咬筋の筋線維の種類と下顎骨形態に影響を及ぼす en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KonoKana en-aut-sei=Kono en-aut-mei=Kana kn-aut-name=河野加奈 kn-aut-sei=河野 kn-aut-mei=加奈 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue= article-no= start-page=23 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Why do rabbits ingest their feces ? kn-title=ウサギはなぜ糞を食べる？ en-subtitle= kn-subtitle= en-abstract= kn-abstract=　The utilization of dietary energy and protein must depend on microbial activity in the gut in every herbivore. For animals adopting the cecum as a microbial habitat, from the viewpoint of the protein utilization, the position of the cecum in the digestive tract is less advantageous than that of foregut fermenters. As a solution to this problem, cecum fermenters perform cecotrophy in order to utilize microbial protein proliferating in the cecum. Cecotrophy is supported by the mechanism that separates microbes from digesta in the colon, sends them back into the cecum and promotes microbial proliferation in the cecum. The colonic separation mechanism can be classified into two types. One is the mucus-trap type separation of bacteria with mucus from digesta in the proximal colon of rodents. The other is the wash-back type separation of particle phase of the colonic contents and liquid phase containing microbes in the colon of rabbits. For microbes guaranteed to inhabit the cecum under colonic separation mechanism, it is necessary for them to obtain sufficient nutrients for survival and proliferation. The source of nitrogen is easily obtained as urea transfered from the blood flow. On the other hand, the energy source is considered to be the limiting factor for bacterial proliferation due to the limited amount of easily usable energy source. In fact, cecal microbial proliferation of rabbits and guinea pigs increases when adding indigestible but fermentable sugars to the feed. As a result, the amount of cecotrophy increases, and the percentage of nitrogen accumulation in the body tends to increase. en-copyright= kn-copyright= en-aut-name=SakaguchiEi en-aut-sei=Sakaguchi en-aut-mei=Ei kn-aut-name=坂口英 kn-aut-sei=坂口 kn-aut-mei=英 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学農学部 en-keyword=Small herbivore kn-keyword=Small herbivore en-keyword=Cecum kn-keyword=Cecum en-keyword=Nitrogen metabolism kn-keyword=Nitrogen metabolism en-keyword=Cecotrophy kn-keyword=Cecotrophy END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue=13 article-no= start-page=33 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=201012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=特集 糖尿病第6の合併症：歯周病 歯周病と糖尿病の相互作用のメカニズム en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=曽我賢彦 kn-aut-sei=曽我 kn-aut-mei=賢彦 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西村英紀 kn-aut-sei=西村 kn-aut-mei=英紀 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院 歯周科 affil-num=2 en-affil= kn-affil=広島大学 END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=資源生物科学研究所年報No.2 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学資源生物科学研究所 kn-aut-sei=岡山大学資源生物科学研究所 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=新規N-メチル-D-アスパラギン酸受容体拮抗薬CNS5161の経皮吸収型製剤化に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NaruseMamoru en-aut-sei=Naruse en-aut-mei=Mamoru kn-aut-name=成瀬守 kn-aut-sei=成瀬 kn-aut-mei=守 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=モルモットの栄養素消化および窒素利用に及ぼすフラクトオリゴ糖の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawasakiKiyonori en-aut-sei=Kawasaki en-aut-mei=Kiyonori kn-aut-name=川ｱ淨教 kn-aut-sei=川ｱ kn-aut-mei=淨教 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=マウスの配偶子形成に関与する遺伝子の機能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KajitaShinpei en-aut-sei=Kajita en-aut-mei=Shinpei kn-aut-name=梶田晋平 kn-aut-sei=梶田 kn-aut-mei=晋平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=速度論パラメータの演繹的補正による腹膜透析時の薬物動態予測に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HoriuchiMizuki en-aut-sei=Horiuchi en-aut-mei=Mizuki kn-aut-name=堀内瑞樹 kn-aut-sei=堀内 kn-aut-mei=瑞樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=口蓋粘膜上皮におけるタイトジャンクションの細胞生物学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShiotsuNoriko en-aut-sei=Shiotsu en-aut-mei=Noriko kn-aut-name=塩津範子 kn-aut-sei=塩津 kn-aut-mei=範子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Betaine/GABAトランスポーター阻害薬NNC 05-2090の神経障害性疼痛に対する効果について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=JinzenjiAyako en-aut-sei=Jinzenji en-aut-mei=Ayako kn-aut-name=秦泉寺紋子 kn-aut-sei=秦泉寺 kn-aut-mei=紋子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=咬合支持の回復による海馬の記憶関連遺伝子発現に関する分子生物学的解析 kn-title=Memory-related gene expression profile of the male rat hippocampus induced by teeth extraction and occlusal support recovery en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IidaSachiyo en-aut-sei=Iida en-aut-mei=Sachiyo kn-aut-name=飯田祥与 kn-aut-sei=飯田 kn-aut-mei=祥与 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=84 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organization and Rules of the Association kn-title=組織・会則 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=79 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Member Directory kn-title=会員名簿 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=78 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=By-Low of membership fee and Notes of Contributors kn-title=会費に関する内規、会報投稿規程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=68 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=65th and 66th Meeting News, and the Secretary Meeting News kn-title=第65 回、第66 回研究会、理事会報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=61 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction of the activity in the Regional Association for Laboratory Animal Science kn-title=地区研究会の活動紹介 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=50 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Review of Studies on Japanese Quails with Grants-in-Aid for Scientific Research kn-title=科学研究費補助金によるウズラの研究課題 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Japanese quails are widely used for experiments are models of birds, such as chickens, and are becoming increasingly important in research fields today. Their experimental usefulness was initially reported in an international journal for academic research by Padgett et al. and Wilson et al. in 1959, and, since then, a large number of researchers in- and outside Japan have conducted surveys and studies to examine their characteristics. In Japan, the first study on Japanese quails with a Grant-in-Aid for Scientific Research was conducted in 1966, followed by a large number of studies examining them. This grant program aims to support original and pioneering research activities, and is also expected to promote studies on Japanese quails in a wide range of research fields, leading to the advancement of all areas. This paper reviews previous studies on Japanese quails, conducted within the 48-year period between 1966 and 2013. They were searched for using the Database of Grants-in-Aid for Scientific Research KAKEN, excluding some research subjects, and are listed chronologically by keyword. Those comparing Japanese quails with other animals or using them as part of the study are also included. en-copyright= kn-copyright= en-aut-name=SatoKatsunori en-aut-sei=Sato en-aut-mei=Katsunori kn-aut-name=佐藤勝紀 kn-aut-sei=佐藤 kn-aut-mei=勝紀 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学農学部 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=46 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction of the newly constructed facility for laboratory animals at Kyoto Pharmaceutical University kn-title=新たに竣工した京都薬科大学バイオサイエンス研究センターの紹介 en-subtitle= kn-subtitle= en-abstract= kn-abstract=New facility for laboratory animals; Bioscience Research Center (BSRC) was founded at Kyoto Pharmaceutical University and it was due to work from September in 2013. The BSRC aims the highest level of scale, equipment and contents within the pharmaceutical universities in JAPAN and more proper animal experiments must be carried out. en-copyright= kn-copyright= en-aut-name=NishikawaTetsu en-aut-sei=Nishikawa en-aut-mei=Tetsu kn-aut-name=西川哲 kn-aut-sei=西川 kn-aut-mei=哲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=京都薬科大学 バイオサイエンス研究センター END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=42 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=New experimental animal facility in the National Center for Geriatrics and Gerontology. kn-title=国立長寿医療研究センター研究所新実験動物施設棟の紹介 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OgisoNoboru en-aut-sei=Ogiso en-aut-mei=Noboru kn-aut-name=小木曽昇 kn-aut-sei=小木曽 kn-aut-mei=昇 aut-affil-num=1 ORCID= en-aut-name=TakanoSatomi en-aut-sei=Takano en-aut-mei=Satomi kn-aut-name=高野聡美 kn-aut-sei=高野 kn-aut-mei=聡美 aut-affil-num=2 ORCID= en-aut-name=MugurumaKaori en-aut-sei=Muguruma en-aut-mei=Kaori kn-aut-name=六車香織 kn-aut-sei=六車 kn-aut-mei=香織 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=独立行政法人 国立長寿医療研究センター研究所実験動物管理室 affil-num=2 en-affil= kn-affil=独立行政法人 国立長寿医療研究センター研究所実験動物管理室 affil-num=3 en-affil= kn-affil=独立行政法人 国立長寿医療研究センター研究所実験動物管理室 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=39 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Breed difference in the regulation of feather coloration in chickens kn-title=ニワトリにおける羽色調節の品種差 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakahashiToru en-aut-sei=Takahashi en-aut-mei=Toru kn-aut-name=高橋徹 kn-aut-sei=高橋 kn-aut-mei=徹 aut-affil-num=1 ORCID= en-aut-name=NishioKaori en-aut-sei=Nishio en-aut-mei=Kaori kn-aut-name=西尾香織 kn-aut-sei=西尾 kn-aut-mei=香織 aut-affil-num=2 ORCID= en-aut-name=OgoshiMaho en-aut-sei=Ogoshi en-aut-mei=Maho kn-aut-name=御輿真穂 kn-aut-sei=御輿 kn-aut-mei=真穂 aut-affil-num=3 ORCID= en-aut-name=TakahashiSumio en-aut-sei=Takahashi en-aut-mei=Sumio kn-aut-name=高橋純夫 kn-aut-sei=高橋 kn-aut-mei=純夫 aut-affil-num=4 ORCID= en-aut-name=TakeuchiSakae en-aut-sei=Takeuchi en-aut-mei=Sakae kn-aut-name=竹内栄 kn-aut-sei=竹内 kn-aut-mei=栄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=4 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=5 en-affil= kn-affil=岡山大学大学院自然科学研究科 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=35 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Behavioral analysis of the effects of long-term treatment with L-ornithine in mice kn-title=マウス行動分析によるL-オルニチン長期投与の効果について en-subtitle= kn-subtitle= en-abstract= kn-abstract=L-ornithine has recently received considerable attention as an anxiolytic-like or antifatigue agent in both human and animal studies. However, most previous results were obtained from a single administration of L-ornithine. Accordingly, this study was designed to clarify the effects of long-term L-ornithine treatment on psychological stress and locomotor activity in mice using a variety of behavioral pharmacology methods. In a stress-induced hyperthermia test, 10 days of L-ornithine treatment induced hyperthermia elevation. Pentobarbital-induced sleep time was shortened by the treatment. However, no significant effects were detected in the elevated plus-maze, running wheel, or forced swim tests. These results suggest that long-term treatment with L-ornithine elevates stress sensitivity and arousal level in mice. en-copyright= kn-copyright= en-aut-name=SogabeSaki en-aut-sei=Sogabe en-aut-mei=Saki kn-aut-name=曽我部咲 kn-aut-sei=曽我部 kn-aut-mei=咲 aut-affil-num=1 ORCID= en-aut-name=SuzukiManami en-aut-sei=Suzuki en-aut-mei=Manami kn-aut-name=鈴木真奈美 kn-aut-sei=鈴木 kn-aut-mei=真奈美 aut-affil-num=2 ORCID= en-aut-name=SaikiAkiko en-aut-sei=Saiki en-aut-mei=Akiko kn-aut-name=佐伯綾希子 kn-aut-sei=佐伯 kn-aut-mei=綾希子 aut-affil-num=3 ORCID= en-aut-name=InoueRikako en-aut-sei=Inoue en-aut-mei=Rikako kn-aut-name=井上里加子 kn-aut-sei=井上 kn-aut-mei=里加子 aut-affil-num=4 ORCID= en-aut-name=HayashiYasushi en-aut-sei=Hayashi en-aut-mei=Yasushi kn-aut-name=林泰資 kn-aut-sei=林 kn-aut-mei=泰資 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=ノートルダム清心女子大学大学院人間生活学研究科食品栄養学専攻 affil-num=2 en-affil= kn-affil=ノートルダム清心女子大学大学院人間生活学研究科食品栄養学専攻 affil-num=3 en-affil= kn-affil=ノートルダム清心女子大学大学院人間生活学研究科食品栄養学専攻 affil-num=4 en-affil= kn-affil=ノートルダム清心女子大学大学院人間生活学研究科食品栄養学専攻 affil-num=5 en-affil= kn-affil=ノートルダム清心女子大学大学院人間生活学研究科食品栄養学専攻 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=25 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Is the Integrated Medicine in Japan possible? kn-title=わが国における統合医療は可能か en-subtitle= kn-subtitle= en-abstract= kn-abstract=The medical treatment called the alternative medicine or complementary and an Integrated medicine is wide and it is said in recent years. It is assumed, "All of the medicine and the Medical treatment except Western medicine that is taught in University Department of Medicine, and done in a general hospital" with the alternative medicine. For instance, I want to examine whether integrated treatment that brings these Alternative medicine and Western medicine treatment together can be done in our country in the document about the strategy though there are Acupuncture & Moxibustion therapy, a Chinese medicine, Supplement, Herb treatment, Ayulbadar, Yoga, Cairopractic, a Shiatsu and a Massage. Aromatherapy, Homeopathy, Reflexology, a Tradition medicine, and a Folk remedy etc, and the Therapeutic gain is raised by each method. It is necessary to build a Central hospital that integrated them according to various places by the method of doing in China, to gather the expert in each treatment field, to make a best treatment Method concept for the patient consulting, to do the system making to which it can treatment equally immediately by all those who treat, and to practice the strategy immediately. en-copyright= kn-copyright= en-aut-name=KurabayashiYuzuru en-aut-sei=Kurabayashi en-aut-mei=Yuzuru kn-aut-name=倉林譲 kn-aut-sei=倉林 kn-aut-mei=譲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部胃腸器外科学教室 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=21 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Reminiscence about Okayama Association for Laboratory Animal Science marked the 30th Anniversary kn-title=創立３０周年を迎えた岡山実験動物研究会の追憶 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NagaiHiroshi en-aut-sei=Nagai en-aut-mei=Hiroshi kn-aut-name=永井廣 kn-aut-sei=永井 kn-aut-mei=廣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=14 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laboratory Animal Welfare ―Researchers using laboratory animals and Laboratory animal technicians should mention their own subjectivity― kn-title=実験動物福祉 −主観で語る覚悟を− en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KitaMegumu en-aut-sei=Kita en-aut-mei=Megumu kn-aut-name=北徳 kn-aut-sei=北 kn-aut-mei=徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=倉敷芸術科学大学動物生命科学科 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=11 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hox gene and development of the auditory circuit kn-title=Hox 遺伝子と聴覚回路の発生 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sound vibration is sensed by hair cells in the inner ear. The information is transmitted to the cochlear nucleus in the brainstem via spiral ganglion neurons. The information is further transmitted to higher relaying centers in the brain such as superior olivary complex and inferior colliculus. The connectivity between these components is topographically organized in a frequency-specific manner. It is known that the organization is well-established from the beginning of the circuit development. However, little is still known about the molecular mechanisms underlying the development of connectivity in the auditory circuit. Homeobox transcription factors of the Hox gene family are known for their involvement in early anterior-posterior axis patterning of neuronal progenitors in the hindbrain. Recent evidence indicates that they also play important roles in late aspects of neuronal development and establishment of topographic circuitry. Moreover, a mutation in the HOXA2 gene has been recently shown to be responsible for hearing deficits in humans. By means of spatiotemporally controlled Hoxa2 and Hoxb2 conditional mutations in the mouse we analyzed the involvement of these factors in auditory circuit development and connectivity. en-copyright= kn-copyright= en-aut-name=NaritaYuichi en-aut-sei=Narita en-aut-mei=Yuichi kn-aut-name=成田裕一 kn-aut-sei=成田 kn-aut-mei=裕一 aut-affil-num=1 ORCID= en-aut-name=Kajari Karmakar en-aut-sei=Kajari Karmakar en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=S?bastien Ducret en-aut-sei=S?bastien Ducret en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Filippo M. Rijli en-aut-sei=Filippo M. Rijli en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=名古屋文理大学健康生活学部 affil-num=2 en-affil= kn-affil=Friedrich Miescher Institute for Biomedical Research affil-num=3 en-affil= kn-affil=Friedrich Miescher Institute for Biomedical Research affil-num=4 en-affil= kn-affil=Friedrich Miescher Institute for Biomedical Research END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=8 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Assessment of acetate on anti-obesity effect with experimental animal kn-title=実験動物を用いた酢酸の肥満抑制効果の評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Acetate is an endogenous metabolite of fatty acid β-oxidation in the liver mitochondria under starved condition. Orally administered acetate is readily absorbed in the blood stream and then taken up by tissues and activates AMP-activated protein kinase (AMPK) by increasing the AMP/ATP ratio. Administered acetate shows a marked reduction in lipid accumulation in the adipose tissue, protection against accumulation of fat in the liver, and improves glucose tolerance. It decreases the transcripts of the lipogenic genes in the liver, indicating an inhibition of lipogenesis in that organ. Furthermore, acetate treatment shows a higher rate of oxygen consumption and a smaller size of lipid droplets in white and brown adipose tissues. It is indicated that acetate taken up has a potential to prevent obesity and obesity-linked type 2 diabetes. en-copyright= kn-copyright= en-aut-name=YamashitaHiromi en-aut-sei=Yamashita en-aut-mei=Hiromi kn-aut-name=山下広美 kn-aut-sei=山下 kn-aut-mei=広美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山県立大学 保健福祉学部 栄養学科 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=7 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Abnormality of water homeostasis of Muscular dystrophic chicken kn-title=筋ジストロフィーニワトリの水分代謝異常 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The muscular dystrophy chicken has been studying as model animal of muscular dystrophy for more than 50 years. Recently, the mutation of WW domain containing E3 ubiquitin protein ligase 1 (WWP1) gene has been identified as a responsible for muscular dystrophy chicken. We observed that muscular dystrophy chicken not only showed the degeneration of skeletal muscles but also produced watery feces. Therefore, we examined the possibility of abnormalities in water metabolism of muscular dystrophy chicken. We first analyzed plasma osmolality and gene expression of aquaporin 2 (AQP2), AQP3 and alpha subunit of the amiloride-sensitive epithelial sodium channel (αENaC) in muscular dystrophy chicken and White Leghorn chicken under normal physiological conditions at five-week old. Subsequently, we analyzed these same parameters after one-day water-deprivation. The main findings of our study are that: I) the plasma osmolality was significantly higher in muscular dystrophic chicken than in White Leghorn; II) kidney αENaC mRNA expression was significantly lower in muscular dystrophic chicken than in White Leghorn; III) AQP2 and AQP3 mRNA expressions in muscular dystrophic chicken were similar in White Leghorn. We suggest that the mutation of WWP1 may cause the abnormality of sodium absorption, and thus muscular dystrophic chicken become hypernatremic. en-copyright= kn-copyright= en-aut-name=SaitoNoboru en-aut-sei=Saito en-aut-mei=Noboru kn-aut-name=齋藤昇 kn-aut-sei=齋藤 kn-aut-mei=昇 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=3 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The role of autophagy of early embryonic development in mice kn-title=マウス初期胚発生におけるオートファジーの役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After fertilization, maternal products which are stored during oogenesis are rapidly degraded and newly zygotic products are synthesized in most animals. This transition, known as an oocyte-to-embryo transition, is critical step for further embryonic development. Considering that the process occurs quickly, bulk degradation system could be highly activated to eliminate maternal products and recycle them to synthesize newly products. We have demonstrated that autophagy, which is cytoplasmic bulk degradation system mediated by the lysosome, is highly induced after fertilization, and autophagy-deficient embryo dies before implantation, suggesting that autophagy is essential for preimplantaion embryonic development. Our recent studies also revealed that lysosomal size and number changes during the embryonic development. Here we will briefly review the autophagy, and discuss the function of autophagy and lysosome in early mouse embryogenesis. en-copyright= kn-copyright= en-aut-name=TsukamotoSatoshi en-aut-sei=Tsukamoto en-aut-mei=Satoshi kn-aut-name=塚本智史 kn-aut-sei=塚本 kn-aut-mei=智史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=独立行政法人 放射線医学総合研究所・研究基盤センター・生物研究推進課 END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=1 end-page=2 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A greeting from President of Okayama Association for Laboratory Animal Science (2014 year) kn-title=2014年度の会長あいさつ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OdaSen-ichi en-aut-sei=Oda en-aut-mei=Sen-ichi kn-aut-name=織田銑一 kn-aut-sei=織田 kn-aut-mei=銑一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=副作用低減化を可能にするレチノイドX受容体アゴニストに関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OsawaFuminori en-aut-sei=Osawa en-aut-mei=Fuminori kn-aut-name=大澤史宜 kn-aut-sei=大澤 kn-aut-mei=史宜 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=胚移植による子牛の効率的生産と核移植胚の子牛生産に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SekizawaFumio en-aut-sei=Sekizawa en-aut-mei=Fumio kn-aut-name=関澤文夫 kn-aut-sei=関澤 kn-aut-mei=文夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Npr2遺伝子の突然変異によりC型ナトリウム利尿ペプチド受容体の機能が欠損したSLWマウスに関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SogawaChiduru en-aut-sei=Sogawa en-aut-mei=Chiduru kn-aut-name=曽川千鶴 kn-aut-sei=曽川 kn-aut-mei=千鶴 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=エイコサペンタエン酸のマクロファージLPL発現抑制を介するVLDL炎症惹起性の抑制作用とCide-aとCide-cの発現抑制を介する脂肪肝形成の抑制作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=jinnoYasutaka en-aut-sei=jinno en-aut-mei=Yasutaka kn-aut-name=神野泰隆 kn-aut-sei=神野 kn-aut-mei=泰隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=173 end-page=175 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Okayama Medical Innovation Center (OMIC)：Approaches for life innovation in the near future kn-title=おかやまメディカルイノベーションセンター（OMIC） ―近未来のライフイノベーションの実現に向けて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KumonHiromi en-aut-sei=Kumon en-aut-mei=Hiromi kn-aut-name=公文裕巳 kn-aut-sei=公文 kn-aut-mei=裕巳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 産学官連携センター END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=GGT1欠損モデルとしてのDWGマウスを用いた生殖機能におけるGGT1の役割に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamadaKaoru en-aut-sei=Yamada en-aut-mei=Kaoru kn-aut-name=山田郁 kn-aut-sei=山田 kn-aut-mei=郁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=アルテミシニンによるPC12細胞の神経突起伸長誘導とその機構に関する神経栄養学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SaRana en-aut-sei=Sa en-aut-mei=Rana kn-aut-name=薩日娜 kn-aut-sei=薩 kn-aut-mei=日娜 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=新規抗凝血薬YM466の低経口吸収性の要因解明および吸収改善に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakemuraSigeo en-aut-sei=Takemura en-aut-mei=Sigeo kn-aut-name=竹村栄生 kn-aut-sei=竹村 kn-aut-mei=栄生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mucociliary clearance (MC) 評価系の構築とMC−経鼻吸収相関に基づいた経鼻吸収予測システムの開発に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=InoueDaisuke en-aut-sei=Inoue en-aut-mei=Daisuke kn-aut-name=井上大輔 kn-aut-sei=井上 kn-aut-mei=大輔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=1,4-dihydroxy-2-naphthoic acid（DHNA）のOVXマウスに対する骨吸収抑制効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KitaKenichro en-aut-sei=Kita en-aut-mei=Kenichro kn-aut-name=喜多憲一郎 kn-aut-sei=喜多 kn-aut-mei=憲一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=末梢神経損傷後の中枢神経における1次ニューロンの収斂投射の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OmuraSinji en-aut-sei=Omura en-aut-mei=Sinji kn-aut-name=大村晋司 kn-aut-sei=大村 kn-aut-mei=晋司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=天然多糖プルランのリン酸化合物と塩化セチルピリジニウム混合液が細胞と生体および口腔内細菌へ与える影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawataYusuke en-aut-sei=Kawata en-aut-mei=Yusuke kn-aut-name=河田有祐 kn-aut-sei=河田 kn-aut-mei=有祐 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page=98 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organization and Rules ofthe Association kn-title=組織・会則 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page=93 end-page=97 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=MemberDirectory kn-title=会員名簿 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page=92 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=By-Low of membership fee and Notes of Contributors kn-title=会費に関する内規、会報投稿規程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page=81 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=63th and 64th Meeting News，and the Secretary Meeting News kn-title=第63回、第64回研究会、理事会報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page=80 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 47th Annual Meeting of Japanese Association for Experimental Animal Technologists kn-title=日本実験動物技術者協会第47回総会in晴れの国岡山 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Okayama Association for Laboratory Animal Science en-aut-sei=Okayama Association for Laboratory Animal Science en-aut-mei= kn-aut-name=岡山実験動物研究会 kn-aut-sei=岡山実験動物研究会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue= article-no= start-page=76 end-page=79 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Institute for Experimental Animals，Ko be University Graduate School of Medicine kn-title=神戸大学医学研究科附属動物実験施設 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShiomiMasashi en-aut-sei=Shiomi en-aut-mei=Masashi kn-aut-name=塩見雅志 kn-aut-sei=塩見 kn-aut-mei=雅志 aut-affil-num=1 ORCID= en-aut-name=ItoTakashi en-aut-sei=Ito en-aut-mei=Takashi kn-aut-name=伊藤隆 kn-aut-sei=伊藤 kn-aut-mei=隆 aut-affil-num=2 ORCID= en-aut-name=KoikeTomonari en-aut-sei=Koike en-aut-mei=Tomonari kn-aut-name=小池智也 kn-aut-sei=小池 kn-aut-mei=智也 aut-affil-num=3 ORCID= en-aut-name=NakamuraShun-ichi en-aut-sei=Nakamura en-aut-mei=Shun-ichi kn-aut-name=中村俊ー kn-aut-sei=中村 kn-aut-mei=俊ー aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=神戸大学医学研究科附属動物実験施設 affil-num=2 en-affil= kn-affil=神戸大学医学研究科附属動物実験施設 affil-num=3 en-affil= kn-affil=神戸大学医学研究科附属動物実験施設 affil-num=4 en-affil= kn-affil=神戸大学医学研究科附属動物実験施設 END