検索結果 50208 件
| フルテキストURL | K0005650_abstract_review.pdf K0005650_summary.pdf K0005650_fulltext.pdf |
|---|---|
| 著者 | 黒田 浩佐| |
| 発行日 | 2018-03-23 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5650号 |
| 学位授与年月日 | 2018-03-23 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005649_abstract_review.pdf K0005649_summary.pdf K0005649_fulltext.pdf |
|---|---|
| 著者 | 二宮 卓之| |
| 発行日 | 2018-03-23 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5649号 |
| 学位授与年月日 | 2018-03-23 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005648_abstract_review.pdf K0005648_summary.pdf K0005648_fulltext.pdf |
|---|---|
| 著者 | 建部 智子| |
| 発行日 | 2018-03-23 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5648号 |
| 学位授与年月日 | 2018-03-23 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005647_abstract_review.pdf K0005647_summary.pdf K0005647_fulltext.pdf |
|---|---|
| 著者 | 吉田 晶| |
| 発行日 | 2018-03-23 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5647号 |
| 学位授与年月日 | 2018-03-23 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005646_abstract_review.pdf K0005646_fulltext.pdf K0005646_fulltext.pdf |
|---|---|
| 著者 | 井田 潤| |
| 発行日 | 2018-03-23 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5646号 |
| 学位授与年月日 | 2018-03-23 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | MolGenetGenomics20180516.pdf |
|---|---|
| 著者 | Sawada, Takahiro| Eguchi, Miho| Asaki, Seiya| Kashiwagi, Ryota| Shimomura, Kousuke| Taguchi, Fumiko| Matsui, Hidenori| Yamamoto, Mikihiro| Noutoshi, Yoshiteru| Toyoda, Kazuhiro| Ichinose, Yuki| |
| キーワード | Flagella motility MexEF-OprN Multidrug efflux pump transporter N-Acyl-homoserine lactone Quorum sensing |
| 備考 | This is an Accepted Manuscript of an article published by Springer Nature 2018 | |
| 発行日 | 2018-03-16 |
| 出版物タイトル | Molecular Genetics and Genomics |
| 巻 | 293巻 |
| 号 | 4号 |
| 出版者 | Springer |
| 開始ページ | 1 |
| 終了ページ | 11 |
| ISSN | 16174615 |
| NCID | AA11547886 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 29549432 |
| DOI | 10.1007/s00438-018-1430-9 |
| Web of Science KeyUT | 000437440800011 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00438-018-1430-9 |
| タイトル（別表記） | Annual report 2017 / Institute of Plant Science and Resources, Okayama University |
|---|---|
| フルテキストURL | IPSR_25.pdf |
| 著者 | 岡山大学資源植物科学研究所| |
| 出版物タイトル | 岡山大学資源植物科学研究所報告 |
| 発行日 | 2018-03-25 |
| 巻 | 25巻 |
| 開始ページ | 1 |
| 終了ページ | 53 |
| ISSN | 2186-4918 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Annual report, Institute of Plant Science and Resources, Okayama University |
|---|---|
| フルテキストURL | IPSR_24.pdf |
| 著者 | 岡山大学資源植物科学研究所| |
| 出版物タイトル | 岡山大学資源植物科学研究所報告 |
| 発行日 | 2017-03-31 |
| 巻 | 24巻 |
| 開始ページ | 1 |
| 終了ページ | 54 |
| ISSN | 2186-4918 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/AMO/55864 |
|---|---|
| フルテキストURL | 72_2_203.pdf |
| 著者 | Sonekatsu, Mayumi| Sonohata, Motoki| Kitajima, Masaru| Kawano, Shunsuke| Mawatari, Masaaki| |
| 抄録 | In the article by Sonekatsu M et al. entitled “Total Hip Arthroplasty for Patients with Residual Poliomyelitis at a Mean Eight Years of Follow-up”, which appeared in the February 2018 issue, Vol.72, No.1, pp17-22, following corrections should be listed. Editorial Office sincerely apologizes for making mistakes in the previous galley proof, therefore republish a corrected version. |
| Amo Type | Erratum with Corrected and Republished Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 203 |
| 終了ページ | 210 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674772 |
| 関連URL | replaces http://doi.org/10.18926/AMO/55658 |
| JaLCDOI | 10.18926/AMO/55863 |
|---|---|
| フルテキストURL | 72_2_197_n.pdf |
| 著者 | Takase, Ken| Kada, Akiko| Iwasaki, Hiromi| Yoshida, Isao| Sawamura, Morio| Yoshio, Nobuyuki| Yoshida, Shinichiro| Iida, Hiroatsu| Otsuka, Maki| Takafuta, Toshiro| Ogata, Yuko| Suehiro, Youko| Hirabayashi, Yukio| Hishita, Terutoshi| Yoshida, Chikamasa| Ito, Takuo| Hidaka, Michihiro| Tsutsumi, Ikuyo| Saito, Akiko M.| Nagai, Hirokazu| |
| 抄録 | Standard therapy for idiopathic thrombocytopenic purpura (ITP) has not been established. We are conducting a multicenter, prospective trial to determine the efficacy and safety of short-term, high-dose dexamethasone therapy in ITP patients aged 18-80 years with platelet counts of <20, 000 /μL, or with <50, 000/ μL and bleeding symptoms. The primary endpoints of this trial are the proportion of responses (complete plus partial response) on day 180 (day 46+180) after the completion of the 46-day high-dose dexamethasone therapy. The results of this investigation of the effectiveness and safety of this regimen will be essential for the establishment of standard therapy for ITP. |
| キーワード | idiopathic thrombocytopenic purpura short-term high-dose dexamethasone therapy open-label single-arm trial |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 197 |
| 終了ページ | 201 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674771 |
| JaLCDOI | 10.18926/AMO/55862 |
|---|---|
| フルテキストURL | 72_2_193.pdf |
| 著者 | Shioji, Naohiro| Kanazawa, Tomoyuki| Iwasaki, Tatsuo| Shimizu, Kazuyoshi| Suemori, Tomohiko| Kawase, Hirokazu| Kimura, Satoshi| Kuroe, Yasutoshi| Morimatsu, Hiroshi| |
| 抄録 | We will investigate the incidence of postoperative pulmonary complications (PPCs) with the prophylactic use of a high-flow nasal cannula (HFNC) after pediatric cardiac surgery. Children < 48 months old with congenital heart disease for whom cardiac surgery is planned will be included. The HFNC procedure will be commenced just after extubation, at a flow rate of 2 L/kg/min with adequate oxygen concentration to achieve target oxygen saturation ≥ 94%. This study will reveal the prevalence of PPCs after pediatric cardiac surgery with the prophylactic use of HFNC. |
| キーワード | high-flow nasal cannula postoperative pulmonary complications pediatric cardiac surgery congenital heart disease |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 193 |
| 終了ページ | 196 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674770 |
| JaLCDOI | 10.18926/AMO/55861 |
|---|---|
| フルテキストURL | 72_2_189.pdf |
| 著者 | Nakao, Shinichiro| Hagiya, Hideharu| Kimura, Keigo| Mitsui, Tomomi| Oyama, Akane| Hongyo, Kazuhiro| Takahashi, Yusuke| Nakagami, Futoshi| Tomono, Kazunori| Rakugi, Hiromi| |
| 抄録 | A 65-year-old Japanese man with bilateral carotid atherosclerosis presented with right neck pain and fever. Contrast-enhanced computed tomography suggested carotid arteritis, and carotid ultrasonography showed an unstable plaque. The patient developed a cerebral embolism, causing a transient ischemic attack. Helicobacter cinaedi was detected in blood culture, and H. cinaedi-associated carotid arteritis was diagnosed. Empirical antibiotic therapy was administered for 6 weeks. After readmission for recurrent fever, he was treated another 8 weeks. Although the relationship between H. cinaedi infection and atherosclerosis development remains unclear, the atherosclerotic changes in our patient’s carotid artery might have been attributable to H. cinaedi infection. |
| キーワード | atherosclerosis bacteremia bacterial translocation Helicobacter cinaedi vascular infection |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 189 |
| 終了ページ | 192 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674769 |
| JaLCDOI | 10.18926/AMO/55860 |
|---|---|
| フルテキストURL | 72_2_185.pdf |
| 著者 | Morizane, Shin| Sugimoto, Saeko| Motoki, Takayuki| Katayama, Norihisa| Omori, Masako| Iwatsuki, Keiji| |
| 抄録 | Psoriasis is a common chronic inflammatory skin disorder that is characterized by scaly, erythematous, sharply demarcated plaques. The treatment for psoriasis has dramatically changed over the last 10 years with the introduction of biologics. However, the risk of cancer induced by biologics for psoriasis has not been fully analyzed, since these agents have such a short history of use. Here we report the case of a 74-year-old woman with psoriasis vulgaris and psoriatic arthritis complicated by breast cancer after systemic treatments including etretinate, cyclosporine, methotrexate, adalimumab, and ustekinumab. |
| キーワード | psoriasis systemic therapy biologics malignancy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 185 |
| 終了ページ | 187 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674768 |
| JaLCDOI | 10.18926/AMO/55859 |
|---|---|
| フルテキストURL | 72_2_181.pdf |
| 著者 | Tsuboi, Chika| Naito, Hiromichi| Hagioka, Shingo| Hanafusa, Hiroaki| Hirayama, Takahiro| Kosaki, Yoshinori| Iida, Atsuyoshi| Yumoto, Tetsuya| Tsukahara, Kohei| Morimoto, Naoki| Nakao, Atsunori| |
| 抄録 | The primary toxicity of hydrogen peroxide results from its interaction with catalase, which liberates water and oxygen. We report the case of a 14-year-old Japanese girl with portal venous gas that was caused by oxygen liberated from intentionally ingested hydrogen peroxide. Although she had a past history of atrial septal defect, recovery without cardiac or neurological sequelae was achieved using hyperbaric oxygen therapy. Emergency physicians must be aware of the danger of liberated oxygen due to hydrogen peroxide ingestion. |
| キーワード | air embolism ASD breaching agent HBO intoxication |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 181 |
| 終了ページ | 183 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674767 |
| JaLCDOI | 10.18926/AMO/55858 |
|---|---|
| フルテキストURL | 72_2_175.pdf |
| 著者 | Hirata, Takeshi| Hanamoto, Masanori| Ogura, Kazuma| Hayashi, Nobuki| Takamura, Kosuke| Edamura, Kohei| Ebara, Shin| Saika, Takashi| |
| 抄録 | There is no standard second-line or salvage treatment for advanced urothelial carcinoma (UC). Here we investigated the efficacy and safety of gemcitabine, cisplatin, and paclitaxel (GCP) combination chemotherapy as salvage chemotherapy for advanced UC. We retrospectively analyzed the cases of 23 patients with advanced UC who showed progression or recurrence after cisplatin-based chemotherapy. Gemcitabine (1000 mg/m2), and paclitaxel (80 mg/m2) were administered on days 1 and 8. Cisplatin (70 mg/m2) was administered on day 1. The 3-week cycle regimen was repeated until disease progression if it had no intolerable toxicity. The overall response rate was 61% (95%CI, 41-78%). The median overall survival and progression-free survival times were 14 months and 5.5 months, respectively. Of the already known risk factors of chemotherapy for advanced UC, only the performance status was a prognostic factor for OS. Overall, 16 of the 23 patients (70%) experienced grade 3/4 toxicities, and no fatal adverse events were observed. GCP therapy was a promising option as second-line or salvage therapy for advanced UC. |
| キーワード | urothelial carcinoma gemcitabine cisplatin paclitaxel second-line salvage |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 175 |
| 終了ページ | 179 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674766 |
| JaLCDOI | 10.18926/AMO/55857 |
|---|---|
| フルテキストURL | 72_2_165.pdf |
| 著者 | Yoshida, Aki| Fujiwara, Tomohiro| Uotani, Koji| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hasei, Joe| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| 抄録 | Although there is considerable evidence indicating that the dysregulation of microRNAs (miRNAs) in malignant tumors plays a role in tumor development, the overall function of miRNAs and their clinicopathological significance are not well understood. In this retrospective analysis of 45 biopsy specimens from osteosarcoma (OS) patients, we investigated the functional and clinical significance of miR-25-3p in OS, which we previously identified as a highly expressed miRNA in OS patients’ serum. We observed that miR-25-3p dysregulation in human OS tissues was negatively correlated with the clinical prognosis, whereas the expression level of its target gene, Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3), was positively correlated with the clinical prognosis. Endogenous miR-25-3p upregulation promoted tumor growth, invasion, and drug resistance, which was consistent with DKK3 silencing in OS cells. In addition, secretory miR-25-3p was embedded in tumor-derived exosomes, where it promoted capillary formation and the invasion of vascular endothelial cells. Overall, our results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in OS, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease. |
| キーワード | microRNA circulating microRNA osteosarcoma prognosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 165 |
| 終了ページ | 174 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674765 |
| JaLCDOI | 10.18926/AMO/55856 |
|---|---|
| フルテキストURL | 72_2_153.pdf |
| 著者 | Kumashiro, Masayuki| Kataoka, Takahiro| Yokota, Shinobu| Nakagawa, Shinobu| Otsuki, Keisuke| Miyake, Nobuyuki| Osumi, Shinji| Yamaoka, Kiyonori| |
| 抄録 | We examined the effects of a reduced exposure dose on the quality of images from an angiography device augmented with a noise reduction algorithm. Before its clinical application, we compared the diameter of the discrimination limit of the hole with that in the conventional method by a visual evaluation with a contrast-detail (C-D) phantom imaged using the target dose. Based on the results, a reducible dose was determined and applied clinically. The sample population consisted of patients being followed up after percutaneous coronary intervention (PCI) for coronary artery disease; we evaluated the effects of the exposure reduction on image quality. A significant dose reduction was observed by the noise-reduction method compared to the conventional method; the radiation dose to the flat panel detector (FPD) could be reduced to 70 nGy per frame. Clinically, a dose reduction of approx. 40% was obtained while maintaining image quality almost equal to that of the conventional method. |
| キーワード | image quality radiation dose noise reduction percutaneous coronary intervention contrast-detail phantom |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 153 |
| 終了ページ | 164 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674764 |
| JaLCDOI | 10.18926/AMO/55855 |
|---|---|
| フルテキストURL | 72_2_143.pdf |
| 著者 | Shinohara, Yoshie| Nakatsuka, Mikiya| |
| 抄録 | We focus on Japanese individuals with gender identity disorder (GID), especially male-to-female (MTF) GID, who have experienced difficulty in adapting to social life. We clarify what gender dysphoria is, and we examine methods of intervention. Semi-structured interviews were conducted with 11 individuals with MTF-GID from August 2015 to April 2017. We categorized the subjects’experiences regarding dysphoria into the ‘Onset of gender dysphoria,’ ‘Experience of feeling gender dysphoria,’ and ‘Changes due to receiving medical care.’ The subjects reported experiencing great pain and distress because they did not fully understand that they were experiencing dysphoria and could not align their gender identity and their self-identity. All subjects described their experiences of dysphoria as negative. Additionally, all said that the dysphoria was alleviated by a medical intervention such as visiting a gender clinic, receiving a diagnosis and treatment, and changing their physical sex to the sex congruent with their gender identity. The provision of information at the gender clinic and the physical changes achieved by medical intervention exerted a positive effect both mentally and socially on the subjects, who suffered various physical, mental and social problems. |
| キーワード | gender identity disorder gender dysphoria gender identity male to female |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 143 |
| 終了ページ | 151 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674763 |
| JaLCDOI | 10.18926/AMO/55854 |
|---|---|
| フルテキストURL | 72_2_137.pdf |
| 著者 | Takahashi, Yuko| Shien, Tadahiko| Sakamoto, Ai| Tsuyumu, Yuko| Yoshioka, Ryo| Uno, Maya| Hatono, Minami| Kochi, Mariko| Kawada, Kengo| Tsukioki, Takahiro| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Matsuoka, Junji| Nakatsuka, Mikiya| Doihara, Hiroyoshi| |
| 抄録 | Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy. Six (35%) patients underwent oocyte cryopreservation, and 11 (65%) married patients opted for embryo cryopreservation. There were no pregnancies among the patients undergoing oocyte cryopreservation, whereas 3 (27%) of the patients who opted for embryo cryopreservation became pregnant. Two (12%) patients stopped endocrine therapy after 2 years in an effort to become pregnant, but their breast cancers recurred. Though the problem of fertility loss for breast cancer patients is important and we should assess the infertility risk for all patients, we should also consider the prognosis. In June 2016, we launched a prospective multicenter cohort study to evaluate the efficacy and safety of fertility preservation in greater detail. |
| キーワード | fertility preservation multidisciplinary breast cancer young patients |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 137 |
| 終了ページ | 142 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674762 |
| JaLCDOI | 10.18926/AMO/55853 |
|---|---|
| フルテキストURL | 72_2_129.pdf |
| 著者 | Okura, Tomohiro| Fujii, Masakuni| Shiode, Junji| Ito, Yuri| Kojima, Toru| Nasu, Junichiro| Niguma, Takefumi| Yoshioka, Masao| Mimura, Tetsushige| Yamamoto, Kazuhide| |
| 抄録 | The impact of body mass index (BMI) on postoperative survival in Japanese patients with pancreatic cancer is unclear. We examined the relationship between preoperative BMI and the prognosis of Japanese patients who underwent surgery for pancreatic cancer to determine whether BMI affects these patients’ prognosis. Of the patients who underwent pancreatectomy between January 2004 and August 2015 at our institution, 246 were pathologically diagnosed with pancreatic tubular adenocarcinoma; the cancer was located in the pancreatic head (n=161) and in the body and tail (n=85). We classified the patients by BMI: underweight (n=22), normal weight (n=190), and overweight/obese (n=34) groups. We retrospectively analyzed medical records for patient characteristics, lesion location, disease stage, postoperative complications, chemotherapy, and prognosis. Lesion location, disease stage, postoperative complications, and chemotherapy were not significantly different among the BMI groups. The median survival times were as follows (days): all patients, 686; underweight, 485; normal weight, 694; and overweight/obese, 839. In a multivariate analysis, after adjusting for competing risk factors, low BMI was associated with an increased risk of death (normal weight: HR 0.58, p=0.038; overweight/obese: HR 0.54, p=0.059). High BMI was not found to be a postoperative factor for poor prognosis in Japanese pancreatic cancer patients. |
| キーワード | pancreatic cancer BMI prognosis surgery risk factor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 129 |
| 終了ページ | 135 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674761 |