検索結果 - 岡山大学学術成果リポジトリ

Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms

フルテキストURL	fulltext20211018-7a.pdf
著者	Watari, Shogo\| Araki, Motoo\| Matsumoto, Jun\| Yoshinaga, Kasumi\| Sekito, Takanori\| Maruyama, Yuki\| Mitsui, Yosuke\| Sadahira, Takuya\| Kubota, Risa\| Nishimura, Shingo\| Wada, Koichiro\| Kobayashi, Yasuyuki\| Takeuchi, Hidemi\| Tanabe, Katsuyuki\| Kitagawa, Masashi\| Morinaga, Hiroshi\| Kitamura, Shinji\| Sugiyama, Hitoshi\| Ariyoshi, Noritaka\| Wada, Jun\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\|
キーワード	Cytochrome P450 tacrolimus renal transplantation CYP2C19 vonoprazan rabeprazole
備考	© 2021 The Japanese Society for the Study of Xenobiotics. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.dmpk.2021.100407] .\|
発行日	2021-10-31
出版物タイトル	Drug Metabolism and Pharmacokinetics
巻	40巻
出版者	Elsevier Ltd.
開始ページ	100407
ISSN	13474367
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
論文のバージョン	author
PubMed ID	34352707
DOI	10.1016/j.dmpk.2021.100407
Web of Science KeyUT	000702719100002
関連URL	isVersionOf https://doi.org/10.1016/j.dmpk.2021.100407

Adipose-Derived Extract Suppresses IL-1 beta-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats

フルテキストURL	fulltext.pdf
著者	Ohashi, Hideki\| Nishida, Keiichiro\| Yoshida, Aki\| Nasu, Yoshihisa\| Nakahara, Ryuichi\| Matsumoto, Yoshinori\| Takeshita, Ayumu\| Kaneda, Daisuke\| Saeki, Masanori\| Ozaki, Toshifumi\|
キーワード	adipose tissue cartilage chondrocyte osteoarthritis IL-1 receptor type 2
発行日	2021-09-10
出版物タイトル	International Journal of Molecular Sciences
巻	22巻
号	18号
出版者	MDPI
開始ページ	9781
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34575945
DOI	10.3390/ijms22189781
Web of Science KeyUT	000699504800001
関連URL	isVersionOf https://doi.org/10.3390/ijms22189781

Short or Irregular Sleep Duration in Early Childhood Increases Risk of Injury for Primary School-Age Children: A Nationwide Longitudinal Birth Cohort in Japan

フルテキストURL	fulltext.pdf
著者	Obara, Takafumi\| Naito, Hiromichi\| Tsukahara, Kohei\| Matsumoto, Naomi\| Yamamoto, Hirotsugu\| Yorifuji, Takashi\| Nakao, Atsunori\|
キーワード	sleep habits trauma problematic behavior longitudinal study
発行日	2021-09-09
出版物タイトル	International Journal of Environmental Research
巻	18巻
号	18号
出版者	MDPI
開始ページ	9512
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34574435
DOI	10.3390/ijerph18189512
Web of Science KeyUT	000699559600001
関連URL	isVersionOf https://doi.org/10.3390/ijerph18189512

Association between Dental Caries and Influenza Infection in Children: A Japanese Nationwide Population-Based Study

フルテキストURL	fulltext.pdf
著者	Matsumoto, Naomi\| Kadowaki, Tomoka\| Tsukahara, Hirokazu\| Yorifuji, Takashi\|
キーワード	dental caries influenza birth cohort oral health
発行日	2021-09-06
出版物タイトル	Children-Basel
巻	8巻
号	9号
出版者	MDPI
開始ページ	780
ISSN	2227-9067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34572212
DOI	10.3390/children8090780
Web of Science KeyUT	000699412100001
関連URL	isVersionOf https://doi.org/10.3390/children8090780

Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions

フルテキストURL	fulltext.pdf
著者	Kataoka, Takahiro\| Shuto, Hina\| Naoe, Shota\| Yano, Junki\| Kanzaki, Norie\| Sakoda, Akihiro\| Tanaka, Hiroshi\| Hanamoto, Katsumi\| Mitsunobu, Fumihiro\| Terato, Hiroaki\| Yamaoka, Kiyonori\|
キーワード	radon oxidative DNA damage Mn-superoxide dismutase (SOD) 8-oxoguanine DNA glycosylase
発行日	2021-08-09
出版物タイトル	Journal of Radiation Research
巻	62巻
号	5号
出版者	Oxford University Press
開始ページ	861
終了ページ	867
ISSN	0449-3060
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021.
論文のバージョン	publisher
PubMed ID	34370027
DOI	10.1093/jrr/rrab069
Web of Science KeyUT	000700078300014
関連URL	isVersionOf https://doi.org/10.1093/jrr/rrab069

Reduction of macrophages by carrageenan decreases oocyst output and modifies local immune reaction in chick cecum with Eimeria tenella

フルテキストURL	fulltext20210924-1.pdf
著者	Ho, Dung Thi\| Pham, Hung Hoang Son\| Aota, Wataru\| Matsubayashi, Makoto\| Tsuji, Naotoshi\| Hatabu, Toshimitsu\|
キーワード	Eimeria tenella Local immune response Macrophage
備考	© 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.rvsc.2021.07.003. \|
発行日	2021-10
出版物タイトル	Research in Veterinary Science
巻	139巻
出版者	Elsevier BV
ISSN	0034-5288
NCID	AA00816614
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Elsevier Ltd.
論文のバージョン	author
PubMed ID	34252703
DOI	10.1016/j.rvsc.2021.07.003
Web of Science KeyUT	000692610100009
関連URL	isVersionOf https://doi.org/10.1016/j.rvsc.2021.07.003

Relationship between Eimeria tenella associated-early clinical signs and molecular changes in the intestinal barrier function

フルテキストURL	fulltext20210924-2.pdf
著者	Pham, Hung Hoang Son\| Matsubayashi, Makoto\| Tsuji, Naotoshi\| Hatabu, Toshimitsu\|
キーワード	Adherens junction Bloody feces Diarrhea Eimeria tenella Epithelial barrier Tight junction
備考	© 2021 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.vetimm.2021.110321] .\|
発行日	2021-10
出版物タイトル	Veterinary Immunology and Immunopathology
巻	240巻
出版者	Elsevier BV
開始ページ	110321
ISSN	0165-2427
NCID	AA00476582
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Elsevier B.V
論文のバージョン	author
DOI	10.1016/j.vetimm.2021.110321
関連URL	isVersionOf https://doi.org/10.1016/j.vetimm.2021.110321

Regulation of germination by targeted mutagenesis of grain dormancy genes in barley

フルテキストURL	fulltext.pdf
著者	Hisano, Hiroshi\| Hoffie, Robert E.\| Abe, Fumitaka\| Munemori, Hiromi\| Matsuura, Takakazu\| Endo, Masaki\| Mikami, Masafumi\| Nakamura, Shingo\| Kumlehn, Jochen\| Sato, Kazuhiro\|
キーワード	Hordeum vulgare seed dormancy targeted genome modification CRISPR Cas9 nuclease pre-harvest sprouting
発行日	2021-08-29
出版物タイトル	Plant Biotechnology Journal
出版者	Wiley
開始ページ	1
終了ページ	10
ISSN	1467-7644
NCID	AA11805223
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	34459083
DOI	10.1111/pbi.13692
Web of Science KeyUT	000695529500001
関連URL	isVersionOf https://doi.org/10.1111/pbi.13692

Temperature-dependent device properties of gamma-CuI and beta-Ga2O3 heterojunctions

フルテキストURL	fulltext.pdf
著者	Rao, Rama Venkata Krishna\| Ranade, Ajinkya K.\| Desai, Pradeep\| Kalita, Golap\| Suzuki, Hiroo\| Hayashi, Yasuhiko\|
キーワード	Gallium oxide gamma-copper iodide Heterojunction Device Temperature dependent
発行日	2021-09-08
出版物タイトル	SN Applied Sciences
巻	3巻
号	10号
出版者	Springer International Publishing AG
開始ページ	796
ISSN	2523-3963
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
DOI	10.1007/s42452-021-04774-3
Web of Science KeyUT	000693897500003
関連URL	isVersionOf https://doi.org/10.1007/s42452-021-04774-3

奥付

フルテキストURL	bgeou_177_colophon.pdf
出版物タイトル	岡山大学大学院教育学研究科研究集録
発行日	2021-08-26
巻	177巻
ISSN	1883-2423
言語	日本語
論文のバージョン	publisher

Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics

フルテキストURL	fulltext.pdf
著者	Ahmed, Feroz\| Yoshida, Yuichi\| Wang, Jin\| Sakai, Kenji\| Kiwa, Toshihiko\|
発行日	2021-07-26
出版物タイトル	AIP Advances
巻	11巻
号	7号
出版者	AIP Publishing
開始ページ	75224
ISSN	2158-3226
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Author(s).
論文のバージョン	publisher
DOI	10.1063/5.0056597
Web of Science KeyUT	000692318200001
関連URL	isVersionOf https://doi.org/10.1063/5.0056597

Tumor Lysis Syndrome due to Eribulin Administration for Metastatic Undifferentiated Pleomorphic Sarcoma of the Buttock

JaLCDOI	10.18926/AMO/62408
フルテキストURL	75_4_533.pdf
著者	Tsuchie, Hiroyuki\| Miyakoshi, Naohisa\| Nagasawa, Hiroyuki\| Shimada, Yoichi\|
抄録	Tumor lysis syndrome (TLS) is a complication of cancer treatment that requires urgent intervention. It is extremely rare in the treatment of soft tissue sarcoma (STS) of the limbs or trunk, and there are currently no reports of TLS occurrence from eribulin therapy. We report the case of a 78-year-old woman with an undiffer-entiated pleomorphic sarcoma on the right buttock. We initiated chemotherapy with intravenous eribulin mesylate. Deterioration of renal function, mild hyperkalemia, hyperuricemia, hypocalcemia, and hyperphos-phatemia were confirmed on examination, suggesting the presence of TLS. We present an extremely rare case of TLS from eribulin for STS.
キーワード	tumor lysis syndrome eribulin soft tissue sarcoma cancer chemotherapy metastasis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	533
終了ページ	538
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511623
Web of Science KeyUT	000696755800002
NAID	120007146034

Laparoscopic Synchronous Resection for Descending Colon Cancer and Tailgut Cyst

JaLCDOI	10.18926/AMO/62407
フルテキストURL	75_4_529.pdf
著者	Inada, Ryo\| Watanabe, Ayako\| Toshima, Toshiaki\| Katsura, Yuki\| Sato, Takuji\| Sui, Kenta\| Oishi, Kazuyuki\| Okabayashi, Takehiro\| Ozaki, Kazuhide\| Shibuya, Yuichi\| Matsumoto, Manabu\| Iwata, Jun\|
抄録	A 67-year-old woman underwent polypectomy for a tumor at the descending colon. Pathologically, the tumor was diagnosed as adenocarcinoma with an invasion of 2000 μm. Computed tomography showed a swollen paracolic lymph node and a mass lesion in the presacral space. Magnetic resonance imaging revealed a multio-cular cystic lesion. On diagnosis of descending colon cancer and tailgut cyst, she underwent synchronous lapa-roscopic resection. Histopathologically, the colon cancer was diagnosed as pT1bN1M0, pStage IIIa. The pre-sacral cystic lesion was diagnosed as a nonmalignant tailgut cyst with negative surgical margin. The patient is currently doing well without recurrence at 28 months.
キーワード	anterior approach laparoscopic resection tailgut cyst
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	529
終了ページ	532
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511622
Web of Science KeyUT	000696755800001
NAID	120007146033

Effects of Protective Measures against COVID-19 on Auditory Communication for People with Hearing Loss

JaLCDOI	10.18926/AMO/62404
フルテキストURL	75_4_511.pdf
著者	Kataoka, Yuko\| Maeda, Yukihide\| Sugaya, Akiko\| Omichi, Ryotaro\| Kariya, Shin\|
抄録	WHO has recommended various measures to combat the COVID-19 pandemic, including mask-wearing and physical distancing. However, these changes impair communication for individuals with hearing loss. We investigated the changes in auditory communication associated with COVID-19 measures in 269 patients (male: 45.7%, female: 54.3%, median age: 54 y.o.). Most patients with hearing loss had difficulty engaging in auditory communication with people wearing masks, especially in noisy surroundings or with physical distanc-ing. These difficulties were noticeable in patients with severe hearing loss. Developing communication support strategies for people with hearing loss is an urgent need while COVID-19 measures are in place.
キーワード	coronavirus disease 2019 (COVID-19) hearing loss communication problem mask physical distance
Amo Type	Short Communication
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	511
終了ページ	516
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511619
Web of Science KeyUT	000709282300005
NAID	120007146030

Association Between Eosinophilia and Late-onset Circulatory Collapse in Preterm Infants: A case-Control Study

JaLCDOI	10.18926/AMO/62403
フルテキストURL	75_4_505.pdf
著者	Okamura, Tomoka\| Washio, Yosuke\| Watanabe, Hirokazu\| Nakanishi, Hidehiko\| Uchiyama, Atsushi\| Tsukahara, Hirokazu\| Kusuda, Satoshi\|
抄録	Late-onset circulatory collapse (LCC) in preterm infants is presumably caused by relative adrenal insufficiency. Because eosinophilia is known to be associated with adrenal insufficiency, we attempted to clarify the relation-ship between eosinophilia and LCC in preterm infants. We divided the cases of the infants (born at < 28 weeks’ gestation) admitted to our neonatal intensive care unit in 2008-2010 into 2 groups: those diagnosed with LCC that received glucocorticoids (LCC group), and those who did not receive glucocorticoids (control group). We compared eosinophil counts between the 2 groups and between before and after glucocorticoid treatment in the LCC group. A total of 28 infants were examined: LCC group (n = 12); control group (n = 16). The peak eosin-ophil counts of the LCC group were significantly higher than those of the control group (median: 1.392 × 109/L vs. 1.033 × 109/L, respectively; p = 0.02). Additionally, in the LCC group, the eosinophil counts declined significantly after glucocorticoid treatment (0.877 × 109/L vs. 0.271 × 109/L, p = 0.003). Eosinophil counts in the LCC group were significantly higher than in the control group and decreased rapidly after gluco-corticoid treatment. These results indicate that eosinophilia may be a factor associated with LCC caused by adrenal insufficiency.
キーワード	late-onset circulatory collapse preterm infant eosinophilia steroid adrenal insufficiency
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	505
終了ページ	509
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511618
Web of Science KeyUT	000709282300004
NAID	120007146046

Effects of Tablet Size and Head Posture on Drug Swallowing: A Preliminary Examination Using Endoscopy in Healthy Subjects

JaLCDOI	10.18926/AMO/62402
フルテキストURL	75_4_495.pdf
著者	Sugiyama, Shuntaro\| Iida, Takatoshi\| Morimoto, Yoshinari\| Yamazaki, Yuki\| Mikuzuki, Lou\| Hayashi, Megumi\|
抄録	Tablet size and head posture have been reported to affect swallowing of medications, but no previous studies have evaluated their effects in detail. Our aim was to investigate for the first time the effect of tablet size and head posture on drug swallowing by endoscopic evaluation in healthy subjects. Round tablets (7 , 10 , 12, and 14 mm in diameter) were swallowed by 15 healthy adults with an endoscope inserted in the neutral, head flex-ion, and head extension positions. Evaluation of swallowing difficulty using a numeric rating scale (NRS), presence or absence of pharyngeal residue and its location, and tablet oral transit time (TOTT) were recorded. In the neutral position, the NRS score was higher with the 14 mm tablets than with the 7 mm tablets. The TOTT with the 7 mm tablets was significantly shorter in the head extension than in the neutral position. Swallowing difficulty increased when the tablet diameter was more than 7 mm. Residues were found in the epi-glottis, pyriform sinus, and tongue base. These findings suggest that head extension shortens the TOTT and assists oral-pharyngeal transport.
キーワード	tablet size head posture swallowing endoscopy pharyngeal residue
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	495
終了ページ	503
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511617
Web of Science KeyUT	000709282300003
NAID	120007146045

Knowledge, Attitude and Practice of Sudanese Health Care Providers toward Ebola Virus Outbreak

JaLCDOI	10.18926/AMO/62401
フルテキストURL	75_4_487.pdf
著者	Kunna, Ezzan\| Yamamoto, Taro\| Nundu, Sabin\| Akintije, Calliope \| Elkhidir, Isam \|
抄録	Ebola virus disease (EVD) is a highly contagious and fatal disease in humans. Healthcare providers (HCPs) are often at the frontline of epidemics and can thus be in jeopardy of contracting EVD. Sudan is at a great risk of an EVD outbreak, as it borders countries that experienced EVD outbreaks. It is therefore imperative in Sudan to assess the HCPs’ awareness and knowledge, attitude, and practice (KAP) about EVD for its control and man-agement and for preparedness. A KAP survey was conducted among 387 HCPs (physicians, nurses and labora-tory technicians) in the three main tertiary hospitals in Khartoum, Sudan. The majority of the survey respon-dents (54.5%) were females, < 30 years old (76.3%), and single (77.4%). Most (94%) had heard about EVD, 62% from classical media. Only 14% had received education or training regarding EVD. About 40% reported being adherent to universal precautions and 72% were willing to deal with EVD patients under safety precau-tions. Only 10% knew of any available standard national guidelines for EVD. Nearly half of the HCPs (47%) rated the potential risk of an EVD outbreak in Sudan as high, and 52% rated health authorities’ effort against it as weak. These findings revealed the HCPs’ insufficient knowledge of EVD and the necessary universal precau-tions. This lack of knowledge would negatively affect the HCPs’ preparedness toward any potential EVD out-break. There is a dire need to train HCPs in Sudan on the management of EVD, including preventive and con-trol measures.
キーワード	Ebola virus Sudan healthcare provider knowledge attitude and practice
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	487
終了ページ	493
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511616
Web of Science KeyUT	000709282300002
NAID	120007146044

Long-term Multidisciplinary Rehabilitation Efficacy in Older Patients After Traumatic Brain Injury: Assessed by the Functional Independence Measure

JaLCDOI	10.18926/AMO/62400
フルテキストURL	75_4_479.pdf
著者	Harada, Akio\| Kawai, Nobuyuki\| Ogawa, Tomoya\| Hatakeyama, Tetsuhiro\| Tamiya, Takashi\|
抄録	Instances of traumatic brain injury (TBI) in the elderly have been increasing along with the aging of popula-tions. In the present study, we examined the effect of aging on long-term multidisciplinary in-patient rehabili-tation efficacy after TBI. Sixty-three patients with physical and cognitive impairments after TBI were enrolled in this study. Patients were divided into 4 age groups (≤ 24, 25-44, 45-64, ≥ 65 years) and the clinical charac-teristics and rehabilitation efficacy of each age group were determined. Functional disability was evaluated using motor and cognitive Functional Independence Measure (FIM) scores. Rehabilitation efficacy was assessed by FIM gains during rehabilitation and compared among the groups. There were no statistically significant dif-ferences in motor and cognitive FIM gains among the age groups. However, cognitive FIM gain was limited in a subset of ≥ 65 patients, and initial cognitive measures could not predict cognitive FIM improvement. These results indicate that chronological age is insufficient to accurately predict rehabilitation efficacy in older TBI patients, and that such patients should be considered candidates for intensive rehabilitation programs based on these results. Accurate prognostication of rehabilitation efficacy with continuing data collection is important when using rehabilitation resources for older TBI patients.
キーワード	aging Functional Independence Measure physical and cognitive impairments traumatic brain injury rehabilitation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	479
終了ページ	486
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511615
Web of Science KeyUT	000709282300001
NAID	120007146043

Two Types of Polyp Shape Observed in the Stomach of Patients with Peutz-Jeghers Syndrome

JaLCDOI	10.18926/AMO/62399
フルテキストURL	75_4_471.pdf
著者	Iwamuro, Masaya\| Toyokawa, Tatsuya\| Matsueda, Kazuhiro\| Hori, Shinichiro\| Yoshioka, Masao\| Moritou, Yuki\| Tanaka, Takehiro\| Mizuno, Motowo\| Okada, Hiroyuki\|
抄録	The characteristics of gastric polyps in patients with Peutz-Jeghers (PJ) syndrome (PJS) have not been fully investigated. The objective of this study was to reveal the endoscopic and pathologic findings of gastric polyps in patients with PJS. We reviewed 11 patients with PJS treated at 6 institutions, and summarized the endo-scopic and pathologic features of their gastric polyps. The polyps were mainly classified into 2 types: (i) soli-tary or sporadic polyps > 5 mm, reddish in color with a sessile or semi-pedunculated morphology (n = 9); and (ii) multiple sessile polyps ≤ 5 mm with the same color tone as the peripheral mucosa (n = 9). Patients who underwent endoscopic mucosal resection for polyps > 5 mm were diagnosed with PJ polyps (n = 2), whereas those who underwent biopsy were diagnosed with hyperplastic polyps. Polyps ≤ 5 mm were pathologically diagnosed as fundic gland polyps or hyperplastic polyps. This study revealed that patients with PJS present with 2 types of polyps in the stomach. Endoscopic mucosal resection of polyps > 5 mm seems necessary for the pathologic diagnosis of PJ polyps.
キーワード	Peutz-Jeghers syndrome esophagogastroduodenoscopy gastric polyps
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	471
終了ページ	477
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511614
Web of Science KeyUT	000701717000001
NAID	120007146042

Bendamustine Plus Rituximab as Salvage Treatment for Patients with Relapsed or Refractory Low-grade B-cell Lymphoma and Mantle Cell Lymphoma: A Single-Center Retrospective Study

JaLCDOI	10.18926/AMO/62398
フルテキストURL	75_4_461.pdf
著者	Murakami, Hiroyuki\| Yoshioka, Takanori\| Moriyama, Takashi\| Ishikawa, Tatsunori\| Makita, Masanori\| Sunami, Kazutaka\|
抄録	Bendamustine plus rituximab (B-R) is an effective therapy for relapsed or refractory (r/r) low-grade B-cell lymphoma (LGBCL) and mantle cell lymphoma (MCL); however, clinical data from Japanese patients treated with B-R therapy are limited. We retrospectively evaluated the efficacy and safety of B-R therapy in 42 patients who received B-R therapy at our hospital for r/r LGBCL and MCL. All patients received intravenous (IV) ritux-imab 375 mg/m2 on day 1 and IV bendamustine 90 mg/m2 on days 2 and 3 every 28 days for up to 6 cycles. The common histologic subtypes were follicular lymphoma (n = 29, 70%), marginal zone lymphoma (n = 6, 14%), and MCL (n = 5, 12%). The overall response rate was 93%, with 62% complete response and complete response unconfirmed. The median progression-free survival (PFS) was 38 months (95% confidence interval [CI], 24.6 to not reached [NR]), and the median overall survival (OS) was 80 months (95% CI, 60.7 to NR). Patients receiving a cumulative dose of bendamustine ≥ 720 mg/m2 showed a significantly longer PFS and OS. Grade 3/4 adverse events (≥ 10%) included neutropenia (55%), lymphopenia (69%), and nausea (24%). B-R therapy was effective and well tolerated, and the cumulative dose of bendamustine was associated with a favorable outcome.
キーワード	bendamustine low grade B-cell lymphoma mantle cell lymphoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	461
終了ページ	469
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511613
Web of Science KeyUT	000697944600008
NAID	120007146041