検索結果 50208 件
| JaLCDOI | 10.18926/AMO/56074 |
|---|---|
| フルテキストURL | 72_3_283.pdf |
| 著者 | Namba, Shihoko| Ikeda, Fusao| Takaguchi, Koichi| Shimomura, Yasuyuki| Yasunaka, Tetsuya| Okada, Hiroyuki| |
| 抄録 | We investigated whether a small amount of blood collected by fingertip blood sampling would be adequate in a mass examination for hepatitis virus infection in Japan. A cross-sectional survey was conducted at health fairs in Kasaoka City and Shodoshima Island, where participants took the hepatitis screening test. A total of 114 consecutive individuals who took the hepatitis screening test were enrolled. Twenty microliters of plasma was successfully obtained from all participants. Among the participants, two had positive results for HBs antigen and two were positive for anti-HCV; all four were > 60 years old and rarely visited the hospital. Thirty-three and 38 patients chronically infected with HBV and HCV, respectively, were examined for confirmatory assays at participating hospitals. All subjects with undetectable serum levels of HBs antigen and anti-HCV had undetectable levels of both markers in fingertip blood, and the levels in serum and fingertip blood were significantly correlated (p<0.01). The lower detection limit of HBs antigen was defined as 0.005 IU/ml, and the cut-off value of anti-HCV was 1.0 by using 10-μl fingertip blood samples. The fingertip blood sampling described herein may be adequate in mass examinations for hepatitis virus testing in Japan. |
| キーワード | fingertip hepatitis test HBV HCV Japan |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 283 |
| 終了ページ | 287 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926006 |
| JaLCDOI | 10.18926/AMO/56073 |
|---|---|
| フルテキストURL | 72_3_275.pdf |
| 著者 | Morizane, Shin| Ouchida, Mamoru| Sunagawa, Ko| Sugimoto, Saeko| Kobashi, Mina| Sugihara, Satoru| Nomura, Hayato| Tsuji, Kazuhide| Sato, Atsushi| Miura, Yoshihiro| Hattori, Hiroaki| Tada, Kotaro| Huh, Wook-Kang| Seno, Akemi| Iwatsuki, Keiji| |
| 抄録 | Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a large multidomain serine protease inhibitor that is expressed in epidermal keratinocytes. Nonsense mutations of the SPINK5 gene, which codes for LEKTI, cause Netherton syndrome, which is characterized by hair abnormality, ichthyosis, and atopy. A single nucleotide polymorphism (SNP) of SPINK5, p.K420E, is reported to be associated with the pathogenesis of atopic dermatitis (AD). We studied all 34 exons of the SPINK5 gene in Japanese 57 AD patients and 50 normal healthy controls. We detected nine nonsynonymous variants, including p.K420E; these variants had already been registered in the SNP database. Among them, p.R654H (n=1) was found as a heterozygous mutation in the AD patients, but not in the control. No new mutation was detected. We next compared the data of the AD patients with data from the Human Genetic Variation Database provided by Kyoto University; a significant difference was found in the frequency of the p.S368N genotype distribution. PolyPhen-2 and SIFT, two algorithms for predicting the functional effects of amino acid substitutions, showed significant scores for p.R654H. Therefore, R654H might be a risk factor for epidermal barrier dysfunction in some Japanese AD patients. |
| キーワード | atopic dermatitis SPINK5 LEKTI serine protease inhibitor epidermal barrier dysfunction |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 275 |
| 終了ページ | 282 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926005 |
| JaLCDOI | 10.18926/AMO/56072 |
|---|---|
| フルテキストURL | 72_3_267.pdf |
| 著者 | Matsuura, Ryutaro| Goto, Sachiko| Sato, Shuhei| Akagi, Noriaki| Tahara, Seiji| |
| 抄録 | We validated a navigator-echo-triggered sequence that drives magnetization before cardiac-gated inversion recovery T1 turbo field echo acquisition, in the sedated free-breathing pediatric population. Cardiac magnetic resonance imaging was performed on sedated infants with single ventricle. We calculated the signal-to-noise ratios and contrast-to-noise ratios of 2 groups of images obtained using respiratory triggering with and without navigator echo. All images were then visually assessed by 2 observers. The signal-to-noise ratio and the contrast-to-noise ratio were significantly higher with than without navigator echo (p<0.01; p<0.05). The visual assessment scores were also consistently better with than without navigator echo (p<0.01). Free-breathing navigator echo was found to have the advantage of decreasing the motion artifact caused by respiration. Cardiacgated inversion recovery T1 turbo field echo sequence for free-breathing navigator-echo-triggered respiration allows for the acquisition, in sedated infants, of diagnostic images whose quality exceeds that of the non-navigator-echo-triggered alternative. |
| キーワード | magnetic resonance imaging navigator echo inversion recovery T1 turbo field echo cardiac infant |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 267 |
| 終了ページ | 273 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926004 |
| JaLCDOI | 10.18926/AMO/56071 |
|---|---|
| フルテキストURL | 72_3_257.pdf |
| 著者 | Asano, Keiichi| Edamatsu, Midori| F. Hatipoglu, Omer| Inagaki, Junko| Ono, Mitsuaki| Ohtsuki, Takashi| Oohashi, Toshitaka| Hirohata, Satoshi| |
| 抄録 | Several research groups demonstrated that ‘a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS)’-family proteases play roles in cancer progression. However, the origins and contributions of these proteases are not known. Here, we demonstrate an association between host-produced ADAMTS4 and early-stage tumor growth. Murine Lewis lung carcinoma (LLC) tumors showed marked expressions of Adamts4 and Adamts5. We examined the contributions and distributions of host-derived Adamts4 and Adamts5 on tumor growth, using Adamts4LacZ/LacZ and Adamts5LacZ/LacZ knockout mice. Interestingly, the Adamts4LacZ/LacZ mice showed enhanced tumor growth compared to wild-type mice at 5-, 10- and 12-days post-inoculation, whereas the Adamts5LacZ/LacZ mice did not show significant differences in tumor growth. We next examined LacZ distribution in LLC tumor-bearing Adamts4LacZ/LacZ mice by β-galactosidase (β-gal) staining. We found that the β-gal-positive signals were strictly localized at the interior areas of the tumor at 10 days post-inoculation. Multiple staining demonstrated that most of the β-gal-positive cells were localized at the tumor vasculature in Adamts4LacZ/LacZ mice. Interestingly, β-gal-positive signals were not co-localized with biglycan after 10 days post-inoculation, excluding the biglycan cleavage by host-derived ADAMTS4. Taken together, these findings illustrate that host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth. |
| キーワード | ADAMTS metalloproteinase extracellular matrix tumor microenvironment mouse |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 257 |
| 終了ページ | 266 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926003 |
| JaLCDOI | 10.18926/AMO/56070 |
|---|---|
| フルテキストURL | 72_3_249.pdf |
| 著者 | Nakahara, Takako| Suemori, Shin-ichiro| Tsujioka, Takayuki| Kataoka, Mikio| Kataoka, Hiromi| Shibakura, Misako| Tohyama, Kaoru| |
| 抄録 | To investigate megakaryocyte (MK) DNA ploidy in various hematological diseases, fluorescence microscopy imaging system (FMI) can be used to analyze DNA ploidy with cell morphology at the single-cell level by using specialized image-processing software. Here we compared DNA ploidy obtained by FMI measured with that obtained flow cytometry (FCM). With FMI, we could evaluate the DNA ploidy in long-term preserved bone marrow smear samples after staining. We next analyzed the MK DNA ploidy in 42 bone marrow smear samples including 26 myeloid neoplasm cases, and we compared the DNA ploidy and platelet counts in the patients' peripheral blood; the production of platelets was significantly high compared to DNA ploidy in the myeloproliferative neoplasms group. The FMI method revealed that the patients with 5q- syndrome exhibited relatively low DNA ploidy despite high platelet counts, and this result suggested that increased DNA ploidy is not indispensable to abundant platelet production. The FMI method for DNA ploidy will be a useful tool to clarify the relationship between DNA ploidy and platelet production by MKs. |
| キーワード | fluorescence microscopy image analysis DNA ploidy megakaryocytes MDS with isolated del(5q) 5q- syndrome |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 256 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926002 |
| JaLCDOI | 10.18926/AMO/56069 |
|---|---|
| フルテキストURL | 72_3_241.pdf |
| 著者 | Kambara, Taiki| Tanimoto, Ryuta| Araki, Motoo| Saika, Takashi| Hashimoto, Hideaki| Oeda, Tadashi| Tsushima, Tomoyasu| Hayata, Shunji| Nasu, Yasutomo| Kobayashi, Yasuyuki| |
| 抄録 | We retrospectively analyzed the factors related to postoperative cardiovascular (CV) events in patients undergoing partial nephrectomy (PN) or radical nephrectomy (RN) for clinical T1 renal cell carcinoma (RCC). We identified 570 patients who underwent PN or RN for T1 renal cell carcinoma between January 1998 and December 2009 at our institution and related hospitals. We determined the cumulative incidence rate of CV events and overall survival (OS) using Kaplan-Meier survival curves with a log-rank test, and we evaluated the risk for an increase in CV events and OS using Cox proportional hazard regression. Of the 570 patients, 171 underwent PN and 399 underwent RN. The type of surgery was not significantly related with CV events. The only factor that significantly increased the risk of CV events in both the univariate (HR 2.67, p=0.006) and multivariate analyses (HR 2.14, p=0.044) was a postoperative estimated glomerular filtration rate (eGFR) <45 ml/min/1.73 m2. Postoperative eGFR was also a significant risk factor for OS in the univariate analysis (HR 2.38, p=0.0104), but not in the multivariate model. Postoperative renal function was a significant independent predictor of the incidence of subsequent CV events. |
| キーワード | renal cell carcinoma nephrectomy partial nephrectomy renal function |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 241 |
| 終了ページ | 247 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926001 |
| JaLCDOI | 10.18926/AMO/56068 |
|---|---|
| フルテキストURL | 72_3_231.pdf |
| 著者 | Darwinata, Agus Eka| Gotoh, Kazuyoshi| Mima, Takehiko| Yamamoto, Yumiko| Yokota, Kenji| Matsushita, Osamu| |
| 抄録 | The bacterium Vibrio alginolyticus, an opportunistic pathogen in humans, has a type III secretion system (T3SS) that is responsible for its cytotoxicity toward eukaryotic cells. The effector of T3SS that is responsible for the cytotoxicity had not been identified. Here we demonstrate that VepA, a homolog of the T3SS effector in V. parahaemolyticus, is required for cytotoxicity in V. alginolyticus. VepA induces lysosomal membrane permeabilization, and it allows the leakage of only small molecules into the cytosol. Our findings revealed that VepA induces cathepsin-independent cell death in mammalian cells. The ferrous ion, one of the small molecules in the lysosome contents, appears to be involved in the cell death caused by V. alginolyticus VepA. |
| キーワード | cell death lysosomal membrane permeability VepA Vibrio alginolyticus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 231 |
| 終了ページ | 239 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926000 |
| JaLCDOI | 10.18926/AMO/56067 |
|---|---|
| フルテキストURL | 72_3_223.pdf |
| 著者 | Ida, Jun| Kotani, Kazuhiko| Miyoshi, Toru| Nakamura, Kazufumi| Kohno, Kunihisa| Asonuma, Hirohiko| Sakuragi, Satoru| Doi, Masayuki| Miki, Takashi| Koyama, Yasushi| Ito, Hiroshi| |
| 抄録 | Lipoprotein(a), or Lp(a), is a low-density lipoprotein-like particle largely independent of known risk factors for, and predictive of, cardiovascular disease (CVD). We investigated the association between baseline Lp(a) levels and the progression of coronary artery calcification (CAC) in patients with hypercholesterolemia undergoing statin therapy. This study was a sub-analysis of a multicenter prospective study that evaluated the annual progression of CAC under intensive and standard pitavastatin treatment with or without eicosapentaenoic acid in patients with an Agatston score of 1 to 999, and hypercholesterolemia treated with statins. We classified the patients into 3 groups according to CAC progression. A total of 147 patients (mean age, 67 years; men, 54%) were analyzed. The proportion of patients with Lp(a) > 30 mg/dL significantly increased as CAC progressed (non-progression; 5.4%, 0 |
| キーワード | lipoprotein(a) coronary artery calcification statins hypercholesterolemia |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 223 |
| 終了ページ | 230 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29925999 |
| JaLCDOI | 10.18926/AMO/56066 |
|---|---|
| フルテキストURL | 72_3_211.pdf |
| 著者 | Ikeda, Chikako| Yokota, Osamu| Miki, Tomoko| Takenoshita, Shintaro| Ishizu, Hideki| Terada, Seishi| Yamada, Norihito| |
| 抄録 | Neurodegenerative diseases in which tau accumulation plays a cardinal role in the pathogenic process are called tauopathies, and when tau isoforms having four repeats of the microtubule binding sites, four-repeat tau, are selectively accumulated as pathological hallmarks, the term four-repeat tauopathy is used. The major four-repeat tauopathies are progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and argyrophilic grain disease (AGD). Historically, neuronal cytopathologies, e.g., neurofibrillary tangles and ballooned neurons, were emphasized as characteristic lesions in PSP and CBD. Now, however, astrocytic tau pathologies, i.e., tufted astrocytes (TAs) and astrocytic plaques (APs), are considered to be highly disease-specific lesions. Although granular/fuzzy astrocytes (GFAs) frequently develop in the limbic system in AGD cases, the specificity is not conclusive yet. Some AGD cases have a few TAs, and to a lesser frequency, a few APs in the frontal cortex and subcortical nuclei. The number of astrocytic tau pathologies including TAs and GFAs increases with the progression of AGD. In this paper, histopathological features of astrocytic tau pathologies in PSP, CBD, and AGD are first reviewed. Then, recent findings regarding the coexistence of these tauopathies are summarized from a viewpoint of astrocytic tau pathologies. Further biochemical and pathological studies focusing tau-positive astrocytic lesions may be useful to increase understanding of the pathological process in four-repeat tauopathies and to develop novel therapeutic strategies for patients with these diseases. |
| キーワード | astrocytic plaque four-repeat tau globular glial inclusion granular fuzzy astrocyte tufted astrocyte |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 211 |
| 終了ページ | 221 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29925998 |
| フルテキストURL | 130_47.pdf |
|---|---|
| 著者 | 岡山医学会| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 47 |
| 終了ページ | 49 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| タイトル（別表記） | The 66th Medical Education Development Center, Seminar and Workshop in Okayama University |
|---|---|
| フルテキストURL | 130_45.pdf |
| 著者 | 那須 保友| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 43 |
| 終了ページ | 44 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.45 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.45 |
| NAID | 130006730883 |
| タイトル（別表記） | The 7th Annual Meeting of Japan Society for Dementia Prevention |
|---|---|
| フルテキストURL | 130_43.pdf |
| 著者 | 阿部 康二| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 43 |
| 終了ページ | 44 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.43 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.43 |
| NAID | 130006730882 |
| フルテキストURL | 130_41.pdf |
|---|---|
| 著者 | 来住 由樹| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 41 |
| 終了ページ | 42 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Migraine treatment using transcatheter closure of a patent foramen ovale |
|---|---|
| フルテキストURL | 130_37.pdf |
| 著者 | 赤木 禎治| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 37 |
| 終了ページ | 39 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.37 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.37 |
| NAID | 130006730885 |
| タイトル（別表記） | Drug interaction (41. Drug interaction in chronic myeloid leukemia therapy) |
|---|---|
| フルテキストURL | 130_33.pdf |
| 著者 | 中本 秋彦 | 鍛治園 誠| 北村 佳久| 千堂 年昭| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 33 |
| 終了ページ | 36 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.33 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.33 |
| NAID | 130006730884 |
| フルテキストURL | 130_31.pdf |
|---|---|
| 著者 | 岡山医学会| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 31 |
| 終了ページ | 32 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.31 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.31 |
| NAID | 130006730879 |
| タイトル（別表記） | New System of Japanese Medical Specialty : Internal Medicine |
|---|---|
| フルテキストURL | 130_25.pdf |
| 著者 | 小比賀 美香子 | 大塚 文男 | 岡田 裕之| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 25 |
| 終了ページ | 30 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.25 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.25 |
| NAID | 130006730864 |
| タイトル（別表記） | Metaplastic carcinoma of the breast : Two cases |
|---|---|
| フルテキストURL | 130_19.pdf |
| 著者 | 元木 崇之| 岩本 高行 | 大森 昌子| 松岡 順治| |
| 抄録 | We treated two patients with a rare metaplastic carcinoma of the breast. Patient 1：A 32-year-old woman presented with a rapidly growing mass（ 7cm） in her right breast. We diagnosed cT3N0M0 Stage IIB breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy and radiotherapy were performed. Patient 2：A 66-year-old postmenopausal woman presented with a left breast mass. We diagnosed cT1N0M0 Stage I breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy was performed. Patients 1 and 2 have achieved relapse-free survivals of 1 year＋2 months and 10 months, respectively. Metaplastic carcinoma of the breast is a rare tumor, and its prognosis is not favorable. The only available treatment is that used for invasive ductal carcinoma；a more specific treatment has not been established. The accumulation of further similar cases and the development of a novel effective treatment are desired. |
| キーワード | 乳癌（breast cancer） 化生癌（metaplastic carcinoma） 化学療法（chemotherapy） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 19 |
| 終了ページ | 23 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.13 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.13 |
| NAID | 130006730866 |
| タイトル（別表記） | A case of a mesenteric desmoid tumor preoperatively distinguished from imaging findings |
|---|---|
| フルテキストURL | 130_13.pdf |
| 著者 | 河合 毅| 渡邉 貴紀| 信久 徹治 | 松本 祐介| 甲斐 恭平| 佐藤 四三| |
| 抄録 | A 73-year-old woman was admitted for closer investigation into an abdominal tumor. Abdominal ultra-sonography, CT, and magnetic resonance imaging showed a discrete abdominal tumor. Especially on MRI, the tumor appeared as a relatively ill-defined whorled soft-tissue thickening within the mesenteric fat, causing angulation or speculation of adjacent bowel mesentery. Surgery was performed under a presumptive diagnosis of a mesojejunum desmoid. The tumor was invading the transverse mesocolon and mesojejunum as well as the third portion of the duodenum and the middle colic artery, and it was close to but apart from the superior mesenteric artery. The tumor was resected, including removal of part of the duodenum and transverse colon. The specimen contained a white solid tumor measuring 14×12×8cm. Pathologic examination showed differentiated fibroblasts and copious collagen fibers. The tumor was negative for CD34, c-kit, S-100, and α-SMA, but positive for β-catenin. On the basis of these findings, we established a diagnosis of mesenteric desmoid tumor of the small intestine. The patient has been followed postoperatively for 2 years, no sign of recurrence, to date. |
| キーワード | 小腸間膜 (mesentery of the small intestine) デスモイド (desomoid) 腸間膜腫瘍 (mesenteric tumor) |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 13 |
| 終了ページ | 18 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.13 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.13 |
| NAID | 130006730865 |
| フルテキストURL | Hetrocycles_95_390.pdf |
|---|---|
| 著者 | Hanaya, Tadashi| Iwasaki, Katsuya| Saeki, Kaori| Hattori, Takafumi| |
| 備考 | Special Issue| |
| 発行日 | 2016-12-19 |
| 出版物タイトル | Heterocycles |
| 巻 | 95巻 |
| 号 | 1号 |
| 出版者 | The Japan Institute of Heterocyclic Chemistry |
| 開始ページ | 390 |
| 終了ページ | 409 |
| ISSN | 0385-5414 |
| NCID | AA00663739 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.3987/COM-16-S(S)32 |
| Web of Science KeyUT | 000405885400032 |
| 関連URL | isVersionOf https://doi.org/10.3987/COM-16-S(S)32 |