肝硬変に対する肝動脈結紮術の実験的研究 第1編 正常動物の肝動脈結紮に関する研究

1) The effect of hepatic artery ligation is different depending on the site of ligation. A mortality rate decreases in order of the case of ligation of coeliac artery, of hepatic artery distal to its junction with gastroduodenal artery, and proximal to it. 2) Arterial circulation of the liver is relatively well reestablished through collateral vessels and adhesions after hepatic artery ligation in rat. Mortality and morbidity following hepatic artery ligation are mainly depending upon the amount of reestablished circulation. Collateral circulation is mainly developed through cappilaries along choledochus, gastrohepatic and hepatoduodenal ligaments and adhesion between the liver and the stomach, in addition to, esophageal vessels and left gastric artery are also available to it. 3) A mortality rate decreases even in multiple ligations of hepatic artery if performed in two stages. This suggests of adaptability of liver to oxygen lack. 4) Histologically, there are found degenerative changes centered the lobules in liver after hepatic artery ligation and decrease of R N A, polysaccharide and glycogen in liver cell are noted histochemically and occasionally fatty degeneration, too. Moderate degree of degenerative changes is noticeable in liver of rats who survived the experiment over the period of one to two months.