| ID | 40755 |
| フルテキストURL | |
| タイトル（別表記） | Studies of the treatment of pulmonary epidermoid carcinoma Part 1. Sensitivity to various anticancer drugs against human pulmonary epidermoid carcinoma xenograft in the hamster
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| 著者 |
瀬戸 匠
岡山大学医学部第二内科学教室
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| 抄録 | Chemotherapy is the only therapeutic modality applicable to patients with advanced pulmonary epidermoid carcinoma (PEC). However, the results of chemotherapy to PEC remain unsatisfactory. It is very important to have an accurate knowledge of the sensitivity of anticancer drugs against PEC in order to establish a successful chemotherapy. The in vivo sensitivity of 12 anticancer drugs was investigated using PEC cell line (EBC-1) xenografts in hamsters.
In the present study, adriamycin, ifosphamide, mitomycin C, methotrexate and cisdichlorodiammineplatinum (II) showed antitumor activity against EBC-1 cells, but the other 6 drugs (ACNU, bleomycin, 5-fluorouracil, neocarzinostatin, procarbazine and vincristine) have no antitumor activity against EBC-1 cells. These results suggest that combination chemotherapy with 3 or 4 drugs with antitumor activity in the present study may be effective to PEC.
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| キーワード | human lung cancer cell line
xenograft
chemosensitivity test
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| 発行日 | 1989-06
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| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
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| 巻 | 101巻
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| 号 | 5-6号
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| 出版者 | 岡山医学会
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| 出版者（別表記） | Okayama Medical Association
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| 開始ページ | 573
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| 終了ページ | 580
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/101/5-6/101_5-6_573/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
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