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ID 67004
フルテキストURL
著者
Nakata, Eiji Department of Orthopedic Surgery, Okayama University Hospital ORCID Kaken ID
Sugihara, Shinsuke Department of Orthopedic Surgery, Shikoku Cancer Center
Nakahara, Ryuichi Department of Orthopedic Surgery, Okayama University Hospital
Katayama, Haruyoshi Department of Orthopedic Surgery, Okayama University Hospital
Itano, Takuto Department of Orthopedic Surgery, Okayama University Hospital
Ozaki, Toshifumi Department of Orthopedic Surgery, Okayama University Hospital Kaken ID publons researchmap
抄録
Objective: Precise assessment of spinal instability is critical before and after radiotherapy (RT) for evaluating the effectiveness of RT. Therefore, we retrospectively evaluated the efficacy of RT in spinal instability over a period of 6 months after RT, utilizing the spinal instability neoplastic score (SINS) in patients with painful spinal metastasis. We retrospectively evaluated 108 patients who received RT for painful vertebral metastasis in our institution. Mechanical pain at metastatic vertebrae, radiological responses of irradiated vertebrae, and spinal instability were assessed. Follow-up assessments were done at the start of and at intervals of 1, 2, 3, 4, and 6 months after RT, with the pain disappearing in 67%, 85%, 93%, 97%, and 100% of the patients, respectively. The median SINS were 8, 6, 6, 5, 5, and 4 at the beginning and after 1, 2, 3, 4, and 6 months of RT, respectively. Multivariate analysis revealed that posterolateral involvement of spinal elements (PLISE) was the only risk factor for continuous potentially unstable/unstable spine at 1 month. In conclusion, there was improvement of pain, and recalcification results in regaining spinal stability over time after RT although vertebral body collapse and malalignment occur in some irradiated vertebrae. Clinicians should pay attention to PLISE in predicting continuous potentially unstable/unstable spine.
キーワード
spinal metastases
spinal instability neoplastic score
radiotherapy
posterolateral involvement of spinal elements
risk factor
発行日
2024-04-30
出版物タイトル
Cancer Control
31巻
出版者
SAGE Publications
ISSN
1073-2748
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
著作権者
© The Author(s) 2024
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1177/10732748241250219
ライセンス
https://creativecommons.org/licenses/by-nc/4.0/
Citation
Nakata E, Sugihara S, Nakahara R, Katayama H, Itano T, Ozaki T. Changes in Spinal Instability After Conventional Radiotherapy for Painful Vertebral Bone Metastases. Cancer Control. 2024;31. doi:10.1177/10732748241250219
助成機関名
Japan Society for the Promotion of Science
助成番号
22K09401
23K08678
23K08698