検索結果 14182 件
| 著者 | Fujita, Hirofumi| Shiosaka, Masahiko| Ogino, Tetsuya| Okimura, Yuya| Utsumi, Toshihiko| Sato, Eisuke F.| Akagi, Reiko| Inoue, Masayasu| Utsumi, Kozo| Sasaki, Junzo| |
|---|---|
| 発行日 | 2008-06-23 |
| 出版物タイトル | Brain Research |
| 巻 | 1206巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Hobara, Narumi| Goda, Mitsuhiro| Yoshida, Namika| Takatori, Shingo| Kitamura, Yoshihisa| Mio, Mitsunobu| Kawasaki, Hiromu| |
|---|---|
| 発行日 | 2008-05-28 |
| 出版物タイトル | Neuroscience |
| 巻 | 150巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Chian, Ri C.| Chung, Jin T.| Niwa, Koji| Sirard, Marc A.| Downey, Bruce R.| Tan, Seang L.| |
|---|---|
| 発行日 | 2003-5 |
| 出版物タイトル | Zygote |
| 巻 | 11巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Said, Syahruddin| Funabashi, Hiroaki| Niwa, Koji| |
|---|---|
| 発行日 | 1999-8 |
| 出版物タイトル | Zygote |
| 巻 | 7巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Kikuchi, Kazuhiro| Ekwall, Hans| Tienthai, Paisan| Kawai, Yasuhiro| Noguchi, Junko| Kaneko, Hiroyuki| Rpdriguez-Martinez, Heriberto| |
|---|---|
| 発行日 | 2002-07-25 |
| 出版物タイトル | Zygote |
| 巻 | 10巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Yokoo, Masaki| Tienthai, Paisan| Kimura, Naoko| Niwa, Koji| Sato, Eimei| Rodriguez-Martinez, Heriberto| |
|---|---|
| 発行日 | 2002-07-25 |
| 出版物タイトル | Zygote |
| 巻 | 10巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Funabashi, Hiroaki| Bandoh, Naoya| Nakahira, Shinobu| Oh, She-hoon| Tsuboi, Seiji| |
|---|---|
| 発行日 | 1999-06-17 |
| 出版物タイトル | Zygote |
| 巻 | 7巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Wang, F.| Nishino, Naoki| |
| キーワード | by-product denaturing gradient gel electrophoresis; silage total mixed ration |
| 備考 | Published with permission from the copyright holder. This is a author's copy,as published in Journal of Dairy Science , 2008 Vol.91 Issue.6 pp.2380-2387 | |
| 発行日 | 2008-06-26 |
| 出版物タイトル | Journal of Dairy Science |
| 巻 | 91巻 |
| 号 | 6号 |
| 開始ページ | 2380 |
| 終了ページ | 2387 |
| ISSN | 00220302 |
| NCID | AA00696476 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.3168/jds.2007-0821 |
| Web of Science KeyUT | 000255945800023 |
| 著者 | Sumimoto, Tetsuhiro| Maruyama, Toshinori| Azuma, Yoshiharu| Goto, Sachiko| Mondou, Munehiro| Furukawa, Noboru| Okada, Saburo| |
|---|---|
| 発行日 | 2002-12 |
| 出版物タイトル | Industrial Technology |
| 巻 | 1巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Sumimoto, Tetsuhiro| Maruyama, Toshinori| Azuma, Yoshiharu| Goto, Sachiko| Mondou, Munehiro| Furukawa, Noboru| Okada, Saburo| |
|---|---|
| 発行日 | 2003-5 |
| 出版物タイトル | Instrumentation and Measurement Technology Conference |
| 巻 | 2巻 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/32910 |
|---|---|
| フルテキストURL | 61_1_9.pdf |
| 著者 | Matsuo, Toshihiko| Matsuo, Chie| Matsuoka, Hiroaki| Kio, Keiko| |
| 抄録 | All children at the age of 1.5 and 3 years in Japan undergo physical, mental, and developmental checkups including dental, eye, and hearing examinations. The vision-screening program consists of 3 steps : questionnaires and home visual acuity testing as the first step (only for 3-year-old children), visual acuity testing by nurses and inspection by medical officers at regional Health Centers as the second step, and detailed examinations by ophthalmologists as the third step. This study aims to reveal the prevalence of strabismus and amblyopia as obtained from data in the vision-screening program. The final diagnoses made by ophthalmologists and sent back to the Health Centers in Okayama City were reviewed to elucidate the prevalence of strabismus, amblyopia, refractive errors, and other diseases in 1.5- and 3-year-old children in Okayama City in 5 years from 2000 to 2004. Of approximately 6,500-6,900 total children, 83.7-86.8% at 1.5 years old and 77.8-81.9% at 3 years old were brought to the Health Centers. The rates of strabismus were 0.01-0.12% at 1.5 years old and 0.20-0.34% at 3 years old, while the rates of amblyopia were 0% at 1.5 years old and 0.13-0.18% at 3 years old. The higher rates of strabismus at 3 years old were attributed mainly to the increase of exotropia and intermittent exotropia. In conclusions, the prevalence of strabismus was different between 1.5- and 3-year-old children. The vision-screening program in Japan functions to detect strabismus and amblyopia. |
| キーワード | strabismus amblyopia esotropia exotropia preschool vision screening program |
| Amo Type | Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-02 |
| 巻 | 61巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 9 |
| 終了ページ | 16 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17332837 |
| Web of Science KeyUT | 000244432400002 |
| JaLCDOI | 10.18926/AMO/32907 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Fujisawa, Toru| Moriwaki, Akiyoshi| Matsushita, Masayuki| Tomizawa, Kazuhito| Matsui, Hideki| |
| 抄録 | Oxytocin (OT) is one of the neuropituitary hormones and is synthesized in the neurons of the paraventricular nucleus (PVN) and supraoptic nucleus (SON). Previous studies have shown that the mRNAs encoding OT are delivered from the soma to both dendrites and axons of the neurons in the PVN and SON. However, it has not been elucidated whether a translational regulation mechanism to enable local synthesis of the hormone exists in the axons of the neurons of PVN and SON. Elongation factor 2 (EF2) is essential for polypeptide synthesis during protein translation. Moreover, phosphorylation of EF2 by EF2 kinase enhances the translation of certain mRNA species. In the present study, in order to shed light on the mechanisms involved in the translational regulation of OT synthesis, we investigated the localization of phosphorylated EF2. Phospho-EF2 was localized in the soma of the neurons in PVN and SON, and in the swellings of the median eminence where axonal tracts of the neurons in the PVN and SON exist. The phosphorylated form was also observed in the rat hypophysis. Moreover, phospho-EF2 and OT were colocalized in a part of the neurons in the PVN and SON. These results suggest that OT may be partially translated in the axons of neurons in the PVN and SON, and then secreted from the pituitary. |
| キーワード | oxytocin PVN SON elongation factor 2 local translation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-06 |
| 巻 | 61巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 161 |
| 終了ページ | 166 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17593952 |
| Web of Science KeyUT | 000247574700005 |
| JaLCDOI | 10.18926/AMO/32906 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Mukai, Takashi| Mimura, Hidefumi| Gobara, Hideo| Takemoto, Mitsuhiro| Himei, Kengo| Hiraki, Takao| Hase, Soichiro| Fujiwara, Hiroyasu| Iguchi, Toshihiro| Tajiri, Nobuhisa| Sakurai, Jun| Yasui, Kotaro| Sano, Yoshifumi| Date, Hiroshi| Kanazawa, Susumu| |
| 抄録 | We report the clinical experience of radiofrequency ablation followed by radiation therapy for large primary lung tumors. Two patients with large primary lung tumors were treated with combined radiofrequency ablation and radiation therapy, and good local control was observed. Combined radiofrequency ablation and radiation therapy that involves minimally invasive techniques appears to be promising for the treatment of large lung tumors. |
| キーワード | radiofrequency ablation lung cancer radiation therapy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-06 |
| 巻 | 61巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 177 |
| 終了ページ | 180 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17593954 |
| Web of Science KeyUT | 000247574700008 |
| JaLCDOI | 10.18926/AMO/32905 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Wu, Hai-Yan| Tomizawa, Kazuhito| Matsui, Hideki| |
| 抄録 | Intracellular calcium is a powerful secondary messenger that affects a number of calcium sensors, including calpain, a Ca2+-dependent cysteine protease, and calcineurin, a Ca2+/calmodulin-dependent protein phosphatase. Maintenance of low basal levels of intracellular calcium allows for the tightly regulated physiological activation of these proteins, which is crucial to a wide variety of cellular processes, such as fertilization, proliferation, development, learning, and memory. Deregulation of calpain and calcineurin has been implicated in the pathogenesis of several disorders, including hypertension, heart disease, diabetes, cerebral ischemia, and Alzheimer's disease. Recent studies have demonstrated an interplay between calpain and calcineurin, in which calpain can directly regulate calcineurin activity through proteolysis in glutamate-stimulated neurons in culture and in vivo. The calpain-mediated proteolytic cleavage of calcineurin increases phosphatase activity, which promotes caspase-mediated neuronal cell death. Thus, the activation of the calpain-calcineurin pathway could contribute to calcium-dependent disorders, especially those associated with Alzheimer's disease and myocardial hypertrophy. Here, we focus briefly on recent advances in revealing the structural and functional properties of these 2 calcium-activated proteins, as well as on the interplay between the 2, in an effort to understand how calpain-calcineurin signaling may relate to the pathogenesis of calcium- dependent disorders. |
| キーワード | calpain calcineurin calcium proteolysis neurodegeneration |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-06 |
| 巻 | 61巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 123 |
| 終了ページ | 137 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17593948 |
| Web of Science KeyUT | 000247574700001 |
| JaLCDOI | 10.18926/AMO/32903 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Wu, Yumei| Tada, Mikiro| Takahata, Kyoya| Tomizawa, Kazuhito| Matsui, Hideki| |
| 抄録 | Neuronal apoptosis is involved in neurodegenerative diseases such as Alzheimer's disease and Parkinson.s disease. An efficient means of preventing it remains to be found. Some n-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA, 22 : 6n-3) and eicosapentaenoic acid (EPA, 20 : 5n-3) have been reported to be protective against the neuronal apoptosis and neuronal degeneration seen after spinal cord injury (SCI) [1]. However, it is unclear which kinds of PUFAs have the most potent ability to inhibit neuronal apoptosis and whether the simultaneous treatment of PUFAs inhibits the apoptosis. In the present study, we compared the abilities of various n-3- and n-6- PUFAs to inhibit the apoptosis induced after the administration of different apoptotic inducers, etoposide, okadaic acid, and AraC, in mouse neuroblastoma cells (Neuro2a). Preincubation with DHA (22 : 6n-3), eicosapentaenoic acid (EPA, 20 : 5n-3), alpha-linolenic acid (alpha-LNA, 18 : 3n-3), linoleic acid (LA, 18 : 2n-6), arachidonic acid (AA, 20 : 4n-3), and gamma-linolenic acid (gamma-LNA, 18 : 3n-6) significantly inhibited caspase-3 activity and LDH leakage but simultaneous treatment with the PUFAs had no effect on the apoptosis of Neuro2a cells. There were no significant differences of the anti-apoptotic eff ect among the PUFAs. These results suggest that PUFAs may not be effective for inhibiting neuronal cell death after acute and chronic neurodegenerative disorders. However, dietary supplementation with PUFAs may be beneficial as a potential means to delay the onset of the diseases and/or their rate of progression. |
| キーワード | polyunsaturated fatty acid (PUFA) neurodegenerative disease caspase neuronal apoptosis DHA |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-06 |
| 巻 | 61巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 147 |
| 終了ページ | 152 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17593950 |
| Web of Science KeyUT | 000247574700003 |
| JaLCDOI | 10.18926/AMO/32900 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Miyatake, Nobuyuki| Wada, Jun| Matsumoto, Sumiko| Nishikawa, Hidetaka| Makino, Hirofumi| Numata, Takeyuki| |
| 抄録 | We re-evaluated the criteria for waist circumference to predict the accumulation of the components of metabolic syndrome. We used data for 3,185 Japanese, aged 20-79 years. Metabolic syndrome has recently been redefined by a new criterion in Japan, in which waist circumference cutoff points, i.e. 85 cm for men and 90 cm for women, are employed. Among the 3,185 Japanese considered in the present study, 335 men (26.8%) and 69 women (3.6%) were diagnosed as having metabolic syndrome. A cutoff point as a predictor for 2 or more components of metabolic syndrome was evaluated by sensitivity/specificity and a receiver operating characteristic (ROC) curve. The optimal point was estimated as being approximately 85 cm of waist circumference in men and 75 cm in women. We therefore recommend a cutoff value, 75 cm of waist circumference, for the criterion of metabolic syndrome in women. |
| キーワード | metabolic syndrome waist circumference sensitivity specifi city receiver operating characteristic (ROC) curve |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-06 |
| 巻 | 61巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 167 |
| 終了ページ | 169 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17593953 |
| Web of Science KeyUT | 000247574700006 |
| JaLCDOI | 10.18926/AMO/32898 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Matsuo, Toshihiko| Masuda, Ikuya| Ota, Kosuke| Yamadori, Ichiro| Sunami, Reiko| Nose, Soichiro| |
| 抄録 | We describe herein 2 patients who developed Vogt-Koyanagi-Harada syndrome in the course of renal biopsy-proven immunoglobulin A (IgA) nephropathy. A 61-year-old man with an 11-year history of IgA nephropathy and a 16-year history of thyroiditis, and a 56-year-old man with a 5-year history of IgA nephropathy developed Vogt-Koyanagi-Harada syndrome. At the time of the eye disease presentation, IgA nephropathy was stable without corticosteroids in both patients. Vogt-Koyanagi-Harada syndrome was successfully treated with intravenous administration of prednisolone tapered from 200 mg daily. Vogt-Koyanagi-Harada syndrome is associated with IgA nephropathy, suggesting a similar autoimmune mechanism for both diseases. |
| キーワード | immunoglobulin A (IgA) nephropathy Vogt-Koyanagi-Harada syndrome (disease) |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-10 |
| 巻 | 61巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 305 |
| 終了ページ | 309 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17971847 |
| Web of Science KeyUT | 000250431700008 |
| JaLCDOI | 10.18926/AMO/32897 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Matsukawa, Akihiro| |
| 抄録 | The innate immune system provides immediate defense against infection and serves as the first line of host defense during infection. In innate immunity, leukocytes such as neutrophils and macrophages recognize and respond to pathogens in a non-specific manner. Therefore, the recruitment and activation of leukocytes are essential in innate immunity, and are governed by a variety of chemical mediators including cytokines. Cytokines are generally divided into 2 types, termed type-1 and type-2 cytokines. Type-1 cytokines are important in local host defense, while type-2 cytokines play a protective role when inflammatory response spreads to the body. These cytokines exert their biological functions through the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1/3/4/6 are transcription factors that mediate IFNgamma/IL-10/IL-12/IL-13 cytokine signaling, respectively. Evidence indicates that STAT proteins have a significant impact on innate immunity during sepsis. This review focuses on recent understandings in the regulation of innate immunity by STAT proteins during sepsis and septic shock. The suppressor of cytokine signaling (SOCS) proteins are a family of SH2 domain-containing cytoplasmic proteins that complete a negative feedback loop to attenuate signal transduction from cytokines that act through the JAK/STAT pathway. The participation of SOCS proteins in sepsis is also discussed. |
| キーワード | cytokines innate immunity sepsis SOCS STAT |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-10 |
| 巻 | 61巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 239 |
| 終了ページ | 245 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17971840 |
| Web of Science KeyUT | 000250431700001 |
| JaLCDOI | 10.18926/AMO/32895 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Miyatake, Nobuyuki| Saito, Takeshi| Wada, Jun| Nishikawa, Hidetaka| Matsumoto, Sumiko| Miyachi, Motohiko| Fujii, Masafumi| Makino, Hirofumi| Numata, Takeyuki| |
| 抄録 | We evaluated the linkage between oxygen uptake at the ventilatory threshold (VT) and muscle strength in subjects with and without metabolic syndrome. We used data of 226 Japanese men with metabolic syndrome and 265 Japanese men without the syndrome. Metabolic syndrome has recently been defined by a new criterion in Japan. Oxygen uptake at VT and muscle strength, i.e. grip strength and leg strength were measured. Oxygen uptake at VT and muscle strength/body weight were found to be significantly lower in subjects with metabolic syndrome than in those without the syndrome. However, the differences did not reach significant levels after adjusting for leg strength/body weight or oxygen uptake at VT. A combination of aerobic exercise and resistance training might be considered for preventing and improving metabolic syndrome. |
| キーワード | metabolic syndrome oxygen uptake ventilatory threshold muscle strength |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-10 |
| 巻 | 61巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 255 |
| 終了ページ | 259 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17971842 |
| Web of Science KeyUT | 000250431700003 |
| JaLCDOI | 10.18926/AMO/32894 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Mifune, Hirofumi| Akaki, Shiro| Ida, Kentaro| Sei, Tetsuro| Kanazawa, Susumu| Okada, Hiroyuki| |
| 抄録 | <P>To evaluate the ability of multidetector-row CT (MDCT) to predict a risk of hemorrhage in patients with esophageal varices, a total of 40 MDCT scans were performed in 29 patients who had been diagnosed with esophageal varices by conventional upper gastrointestinal tract endoscopy. In 11 patients, MDCT was performed both before and after endoscopic injection sclerotherapy (EIS). Endoscopically, the red color sign (RC sign) was present in 28 scans. Of the 11 patients who underwent EIS, the RC sign disappeared after EIS in 9. The MDCT scans were obtained in the arterial, portal, and equilibrial phases, and the portal phase images were used in this study. Subsequently, the extent of esophageal varices was categorized into four MDCT scores. The variceal score, the maximum short axis of the varices, and the presence of palisade vein dilatation obtained from MDCT had significant correlation with endoscopic variceal forms, and the presence and severity of RC sign, respectively (p<0.01). All cases with a maximum minor axis of more than 4 mm showed positive RC sign. MDCT was useful in the evaluation of esophageal varices for predicting a risk of hemorrhage. |
| キーワード | esophageal varices red color sign MDCT |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2007-10 |
| 巻 | 61巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 247 |
| 終了ページ | 254 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 17971841 |
| Web of Science KeyUT | 000250431700002 |