| ID | 13710 |
| Eprint ID | 13710
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| フルテキストURL | |
| タイトル（別表記） | Combination cancer therapy with local and systemic injection of biological response modifiers (BRMs) in mice
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| 著者 |
村上 努士
岡山大学医学部第一外科学教室
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| 抄録 | To evaluate local Shwartzman's phenomenon in the treatment of malignant tumor, mice were given local injections followed by intravenous injections of biological response modifiers (BRMs). An intradermal injection of IL-1β and TNFα followed by an intravenous injection of OK-432 24 hours later induced acute inflammation with hemorrhage and necrosis at the injection site. An intratumoral injection of these cytokines into MH-134 tumor in the back followed by an intravenous injection of OK-432 induced similar hemorrhage and necrosis in the tumor, and repetition of combined injections suppressed tumor growth and prolonged survival in tumor-bearing mice. Intravenous injections of TNFα were also effective as an eliciting agent in this tumor therapy model. These results indicated serial local and systemic combination therapy with BRMs may be a new clinical therapy for patients with malignant tumor.
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| キーワード | biological response modifier (BRM)
interleukin-1β (IL-1β)
tumor necrosis factor α (TNFα)
OK-432
Shwartzman 反応
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| 備考 | 原著
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| 発行日 | 1996-06-29
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| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
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| 巻 | 108巻
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| 号 | 3-6号
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| 出版者 | 岡山医学会
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| 出版者（別表記） | Okayama Medical Association
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| 開始ページ | 107
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| 終了ページ | 116
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/108/3-6/108_3-6_107/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
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