検索結果 - 岡山大学学術成果リポジトリ

Significant delayed conduction and characteristic ventricular tachycardias in patients with cardiac sarcoidosis and electrical storm

フルテキストURL	fulltext20240109-05.pdf
著者	Morita, Hiroshi\| Nakagawa, Koji\| Ueoka, Akira\| Mizuno, Tomofumi\| Masuda, Takuro\| Asada, Saori\| Miyamoto, Masakazu\| Kawada, Satoshi\| Nishii, Nobuhiro\| Nakamura, Kazufumi\|
キーワード	cardiac sarcoidosis ventricular tachycardia electrical storm ventricular fibrillation sudden cardiac death
備考	This is the peer reviewed version of the following article: [Morita H, Nakagawa K, Ueoka A, et al. Significant delayed conduction and characteristic ventricular tachycardias in patients with cardiac sarcoidosis and electrical storm. J Cardiovasc Electrophysiol. 2024; 35: 307-316. doi:10.1111/jce.16156], which has been published in final form at [https://doi.org/10.1111/jce.16156]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This fulltext file will be available in Dec. 2024.\|
発行日	2023-12-17
出版物タイトル	Journal of Cardiovascular Electrophysiology
巻	35巻
号	2号
出版者	Wiley
開始ページ	307
終了ページ	316
ISSN	1045-3873
NCID	AA10756304
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Wiley Periodicals LLC.
論文のバージョン	author
PubMed ID	38105352
DOI	10.1111/jce.16156
Web of Science KeyUT	001126733400001
関連URL	isVersionOf https://doi.org/10.1111/jce.16156

Concomitant Use of Multiple Nephrotoxins including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity: Combined Retrospective Analyses of Two Real-World Databases

JaLCDOI	10.18926/AMO/66151
フルテキストURL	77_6_595.pdf
著者	Bando, Takashi\| Chuma, Masayuki\| Hamano, Hirofumi\| Niimura, Takahiro\| Okada, Naoto\| Kondo, Masateru\| Izumi, Yuki\| Ishida, Shunsuke\| Yoshioka, Toshihiko\| Asada, Mizuho\| Zamami, Yoshito\| Takechi, Kenshi\| Goda, Mitsuhiro\| Miyata, Koji\| Yagi, Kenta\| Izawa-Ishizawa, Yuki\| Azuma, Momoyo\| Yanagawa, Hiroaki\| Tasaki, Yoshikazu\| Ishizawa, Keisuke\|
抄録	There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN.
キーワード	vancomycin-associated nephrotoxicity polypharmacy nephrotoxin spontaneous adverse event reporting database electronic medical records
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-12
巻	77巻
号	6号
出版者	Okayama University Medical School
開始ページ	595
終了ページ	605
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38145933
Web of Science KeyUT	001164631200004

Cochlear Implantation in the Poorer-Hearing Ear Is a Reasonable Choice

JaLCDOI	10.18926/AMO/66150
フルテキストURL	77_6_589.pdf
著者	Omichi, Ryotaro\| Kariya, Shin\| Maeda, Yukihide\| Fukushima, Kunihiro\| Kataoka, Yuko\| Sugaya, Akiko\| Nishizaki, Kazunori\| Ando, Mizuo\|
抄録	Choosing the optimal side for cochlear implantation (CI) remains a major challenge because of the lack of evidence. We investigated the choice of the surgery side for CI (i.e., the better- or poorer-hearing ear) in patients with asymmetric hearing. Audiological records of 74 adults with a unilateral hearing aid who had undergone surgery at Okayama University Hospital were reviewed. The definition of ‘better-hearing ear’ was the aided ear, and the unaided ear was considered the poorer-hearing ear. We performed a multiple regression analysis to identify potential predictors of speech recognition performance after unilateral CI in the patients. Fifty-two patients underwent CI in the poorer-hearing ear. The post-Ci bimodal hearing rate was far higher in the poorer-ear group (77.8% vs. 22.2%). A multivariate analysis revealed that prelingual hearing loss and the patient’s age at CI significantly affected the speech recognition outcome (beta coefficients: 24.6 and −0.33, 95% confidence intervals [11.75-37.45] and [−0.58 to −0.09], respectively), but the CI surgery side did not (−6.76, [−14.92-1.39]). Unilateral CI in the poorer-hearing ear may therefore be a reasonable choice for adult patients with postlingual severe hearing loss, providing a greater opportunity for postoperative bimodal hearing.
キーワード	cochlear implantation poorer hearing ear better hearing ear hearing aids speech recognition
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-12
巻	77巻
号	6号
出版者	Okayama University Medical School
開始ページ	589
終了ページ	593
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38145932
Web of Science KeyUT	001164631200003

日本の教育学は新カント派をどう読んだのか― 篠原助市文庫の書誌調査から ―

JaLCDOI	10.18926/bgeou/66128
タイトル（別表記）	How did Educational Scholars in Japan Read Neo-Kantian? Bibliographic-Research on Shinohara Library
フルテキストURL	bgeou_184_009_030.pdf
著者	宮本勇一\| 深見奨平\| 佐藤宗大\|
抄録	本稿は，「篠原助市教育学の形成過程に関する教育学説史的研究：新カント派受容に着目して」の一環として，京都大学教育学部図書館の篠原助市・陽二文庫の書誌調査から，戦前期日本の教育学者が新カント派のテクストの「どれ」を「いつ」「どのように」読んだのかについて，篠原助市の生涯と彼の著作『教育の本質と教育学』（1930 年）に焦点を当てて検討したものである。書誌調査から，篠原助市文庫のほとんどが陽二のものであることがわかった。篠原は学校に務めていたころにナトルプの解説書から新カント派に出会ったが，本格的にこれに習熟するようになるのは京都帝国大学入学以後であることがわかった。京都帝国大学から東京高等師範学校時代はヴィンデルバント（新カント派のバーデン学派）により重点を置いた読書を重ね，その歴史哲学的指向性を受容するも，その後1923 年から1930 年までの東北帝国大学時代には，博論執筆に向けてナトルプ（マールブルク学派）を深めており，バーデン学派の思想的成熟は『本質』執筆以後の1930 年代に成し遂げられたことがわかった。篠原の『本質』における新カント派受容をナトルプに限定し，その解釈を「補完・敷衍」「憑依・同調」「当馬・対立」という類型で整理した。
キーワード	篠原助市新カント派ナトルプ戦後教育学
出版物タイトル	岡山大学大学院教育学研究科研究集録
発行日	2023-11-24
巻	184巻
開始ページ	9
終了ページ	30
ISSN	1883-2423
言語	日本語
論文のバージョン	publisher

Optimal liver drainage rate for survival in patients with unresectable malignant hilar biliary obstruction using 3D-image volume analyzer

フルテキストURL	fulltext.pdf
著者	Morimoto, Kosaku\| Matsumoto, Kazuyuki\| Obata, Taisuke\| Oda, Takashi\| Miyamoto, Kazuya\| Matsumi, Akihiro\| Terasawa, Hiroyuki\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Kato, Hironari\| Otsuka, Motoyuki\|
キーワード	biliary obstruction chemotherapy CT volumetry endoscopic biliary drainage self-expandable metal stent
発行日	2023
出版物タイトル	Therapeutic Advances in Gastroenterology
巻	16巻
出版者	SAGE Publications
ISSN	1756-283X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s), 2023.
論文のバージョン	publisher
PubMed ID	37900006
DOI	10.1177/17562848231206980
Web of Science KeyUT	001097731700001
関連URL	isVersionOf https://doi.org/10.1177/17562848231206980

Significant Delayed Activation on the Right Ventricular Outflow Tract Represents Complete Right Bundle -Branch Block Pattern in Brugada Syndrome

フルテキストURL	K0006896_abstract_review.pdf K0006896_fulltext.pdf K0006896_summary.pdf
著者	森本芳正\|
発行日	2023-09-25
資料タイプ	学位論文
学位授与番号	甲第6896号
学位授与年月日	2023-09-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2023 The Authors.

Prevalence and Treatment of Arrhythmias in Patients With Transthyretin and Light-Chain Cardiac Amyloidosis

フルテキストURL	K0006893_abstract_review.pdf K0006893_fulltext.pdf
著者	宮本真和\|
発行日	2023-09-25
資料タイプ	学位論文
学位授与番号	甲第6893号
学位授与年月日	2023-09-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2023, THE JAPANESE CIRCULATION SOCIETY

Endoscopic Manifestations and Clinical Characteristics of Localized Gastric Light-Chain Amyloidosis

JaLCDOI	10.18926/AMO/65978
フルテキストURL	77_5_545.pdf
著者	Iwamuro, Masaya\| Tanaka, Shouichi\| Toyokawa, Tatsuya\| Nishimura, Mamoru\| Tsuzuki, Takao\| Miyahara, Koji\| Negishi, Shin\| Ohya, Shogen\| Tanaka, Takehiro\| Otsuka, Motoyuki\|
抄録	To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant.
キーワード	esophagogastroduodenoscopy gastric lesion amyloidosis light chain
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-10
巻	77巻
号	5号
出版者	Okayama University Medical School
開始ページ	545
終了ページ	552
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37899266
Web of Science KeyUT	001094245100001

Childcare and Child Development in Japan

JaLCDOI	10.18926/AMO/65970
フルテキストURL	77_5_479.pdf
著者	Murata, Akiko\| Matsumoto, Naomi\| Miyaji, Chikara\| Takao, Soshi\| Yorifuji, Takashi\|
抄録	For decades, the notion has persisted in developed countries that exclusive care by the mothers is best for the development of children up to 3 years of age. To examine the veracity of this “myth of the first three years” in Japan, we examined the effects of childcare facility use for children younger than 3 years on their development using the cohorts of the Longitudinal Survey of Newborns in the 21st Century conducted in Japan. Of the 47,015 respondents to the survey, we studied the children of 5,508 mothers with university/professional education to evaluate the relationships between primary early (< 2.5 years) childcare providers during weekday daytime hours and specific development indices for the ages of 2.5, 5.5, and 8 years. At the age of 2.5 and 5.5 years, children attending childcare facilities were judged as having more advanced developmental behaviors by their parents, such as being able to compose a two-word sentence (adjusted odds ratio [aOR]: 0.22) or to express emotions (aOR: 0.81), compared with those cared for by mothers. However, at the age of 8 years, children who attended childcare facilities as infants < 2.5 years showed more aggressive behavior in interrupting people (aOR: 1.20) and causing disturbances in public (aOR: 1.26) than those cared for by mothers (after adjustment for numerous child and parental factors). Although these results are generally consistent with previous studies, issues potentially involved with problem behavior such as quality of childcare require further investigation, as does the case of children of mothers with more modest educational attainment.
キーワード	“myth of the first three years” childcare child development problem behavior educational attainment
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-10
巻	77巻
号	5号
出版者	Okayama University Medical School
開始ページ	479
終了ページ	490
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37899259
Web of Science KeyUT	001108661600005

Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo

フルテキストURL	fulltext.pdf
著者	Khazan, Negar\| Kim, Kyu Kwang\| Hansen, Jeanne N.\| Singh, Niloy A.\| Moore, Taylor\| Snyder, Cameron W. A.\| Pandita, Ravina\| Strawderman, Myla\| Fujihara, Michiko\| Takamura, Yuta\| Jian, Ye\| Battaglia, Nicholas\| Yano, Naohiro\| Teramoto, Yuki\| Arnold, Leggy A.\| Hopson, Russell\| Kishor, Keshav\| Nayak, Sneha\| Ojha, Debasmita\| Sharon, Ashoke\| Ashton, John M.\| Wang, Jian\| Milano, Michael T.\| Miyamoto, Hiroshi\| Linehan, David C.\| Gerber, Scott A.\| Kawar, Nada\| Singh, Ajay P.\| Tabdanov, Erdem D.\| Dokholyan, Nikolay V.\| Kakuta, Hiroki\| Jurutka, Peter W.\| Schor, Nina F.\| Rowswell-Turner, Rachael B.\| Singh, Rakesh K.\| Moore, Richard G.\|
発行日	2022-04-11
出版物タイトル	Journal of Medicinal Chemistry
巻	65巻
号	8号
出版者	American Chemical Society (ACS)
開始ページ	6039
終了ページ	6055
ISSN	0022-2623
NCID	AA00702411
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
PubMed ID	35404047
DOI	10.1021/acs.jmedchem.1c01878
Web of Science KeyUT	000797573100012
関連URL	isVersionOf https://doi.org/10.1021/acs.jmedchem.1c01878

The efficacy of non-anesthesiologist-administered propofol sedation with a target-controlled infusion system during double-balloon endoscopic retrograde cholangiopancreatography

フルテキストURL	fulltext.pdf
著者	Miyamoto, Kazuya\| Matsumoto, Kazuyuki\| Obata, Taisuke\| Sato, Ryosuke\| Matsumi, Akihiro\| Morimoto, Kosaku\| Ogawa, Taiji\| Terasawa, Hiroyuki\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Uchida, Daisuke\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Kato, Hironari\| Otsuka, Motoyuki\|
キーワード	Balloon-assisted endoscopy Propofol Diazepam Sedation
備考	The version of record of this article, first published in BMC Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12876-023-02936-8\|
発行日	2023-09-04
出版物タイトル	BMC Gastroenterology
巻	23巻
号	1号
出版者	BMC
開始ページ	296
ISSN	1471-230X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023.
論文のバージョン	publisher
PubMed ID	37667224
DOI	10.1186/s12876-023-02936-8
Web of Science KeyUT	001063014700002
関連URL	isVersionOf https://doi.org/10.1186/s12876-023-02936-8

Rationale, design and baseline characteristics of the effect of canagliflozin in patients with type 2 diabetes and microalbuminuria in the Japanese population: The CANPIONE study

フルテキストURL	fulltext.pdf
著者	Miyamoto, Satoshi\| Heerspink, Hiddo J. L.\| de Zeeuw, Dick\| Toyoda, Masao\| Suzuki, Daisuke\| Hatanaka, Takashi\| Nakamura, Tohru\| Kamei, Shinji\| Murao, Satoshi\| Hida, Kazuyuki\| Ando, Shinichiro\| Akai, Hiroaki\| Takahashi, Yasushi\| Koya, Daisuke\| Kitada, Munehiro\| Sugano, Hisashi\| Nunoue, Tomokazu\| Nakamura, Akihiko\| Sasaki, Motofumi\| Nakatou, Tatsuaki\| Fujimoto, Kei\| Kawanami, Daiji\| Wada, Takashi\| Miyatake, Nobuyuki\| Yoshida, Michihiro\| Shikata, Kenichi\| the CANPIONE study Investigators\|
キーワード	canagliflozin CANPIONE study diabetic kidney disease eGFR slope SGLT2 inhibitor urinary albumin-to-creatinine ratio
発行日	2022-05-18
出版物タイトル	Diabetes, Obesity and Metabolism
巻	24巻
号	8号
出版者	Wiley
開始ページ	1429
終了ページ	1438
ISSN	1462-8902
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors.
論文のバージョン	publisher
PubMed ID	35491532
DOI	10.1111/dom.14731
Web of Science KeyUT	000822653700001
関連URL	isVersionOf https://doi.org/10.1111/dom.14731

Comparison of Bilateral and Trisegment Drainage in Patients with High-Grade Hilar Malignant Biliary Obstruction: A Multicenter Retrospective Study

フルテキストURL	fulltext.pdf
著者	Matsumoto, Kazuyuki\| Kato, Hironari\| Morimoto, Kosaku\| Miyamoto, Kazuya\| Saragai, Yosuke\| Kawamoto, Hirofumi\| Okada, Hiroyuki\|
キーワード	Bile duct obstruction Neoplasms Endoscopic biliary drainage Bilateral drainage Self-expandable metallic stents
発行日	2022-07-19
出版物タイトル	Gut and Liver
巻	17巻
号	1号
出版者	The Editorial Office of Gut and Liver
開始ページ	170
終了ページ	178
ISSN	1976-2283
NCID	AA12329814
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Gut and Liver.
論文のバージョン	publisher
PubMed ID	35851039
DOI	10.5009/gnl220012
Web of Science KeyUT	000830704600001
関連URL	isVersionOf https://doi.org/10.5009/gnl220012

Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan

JaLCDOI	10.18926/AMO/65749
フルテキストURL	77_4_387.pdf
著者	Kataoka, Takahiro\| Habu, Hiroshi\| Tanaka, Ayumi\| Naoe, Shota\| Murakami, Kaito\| Fujimoto, Yuki\| Yukimine, Ryohei\| Takao, Soshi\| Mitsunobu, Fumihiro\| Yorifuji, Takashi\| Yamaoka, Kiyonori\|
抄録	No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis.
キーワード	radon hot spring bathing habit self-rated health cross-section study
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	387
終了ページ	394
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635139
Web of Science KeyUT	001163659800003

Disease Progression-Related Markers for Aged Non-Alcoholic Fatty Liver Disease Patients

JaLCDOI	10.18926/AMO/65748
フルテキストURL	77_4_377.pdf
著者	Morimoto, Kosaku\| Takeuchi, Yasuto\| Takaki, Akinobu\| Wada, Nozomu\| Oyama, Atsushi\| Adachi, Takuya\| Onishi, Hideki\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker.
キーワード	NAFLD NASH liver fibrosis chemokine FIB-4
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	377
終了ページ	385
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635138
Web of Science KeyUT	001163659800009

Feasibility of Flow Cytometry Analysis of Gastrointestinal Tract-Residing Lymphocytes in Hematopoietic Stem Cell Transplant Recipients

JaLCDOI	10.18926/AMO/65740
フルテキストURL	77_4_347.pdf
著者	Iwamuro, Masaya\| Kondo, Takumi\| Ennishi, Daisuke\| Fujii, Nobuharu\| Matsuoka, Ken-ichi\| Takahashi, Takahide\| Hirabata, Araki\| Tanaka, Takehiro\| Otsuka, Fumio\| Maeda, Yoshinobu\| Okada, Hiroyuki\|
抄録	The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry.
キーワード	flow cytometry stem cell transplantation transplantation-associated microangiopathy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	347
終了ページ	357
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635134
Web of Science KeyUT	001163659800002

Development of Hydrophobic Cell-Penetrating Stapled Peptides as Drug Carriers

フルテキストURL	fulltext.pdf
著者	Tsuchiya, Keisuke\| Horikoshi, Kanako\| Fujita, Minami\| Hirano, Motoharu\| Miyamoto, Maho\| Yokoo, Hidetomo\| Demizu, Yosuke\|
キーワード	cell-penetrating peptide stapled peptide hydrophobic peptide helical structure plasmid DNA delivery
発行日	2023-07-21
出版物タイトル	International Journal of Molecular Sciences
巻	24巻
号	14号
出版者	MDPI
開始ページ	11768
ISSN	1661-6596
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	37511527
DOI	10.3390/ijms241411768
Web of Science KeyUT	001038508200001
関連URL	isVersionOf https://doi.org/10.3390/ijms241411768

Significant Delayed Activation on the Right Ventricular Outflow Tract Represents Complete Right Bundle-Branch Block Pattern in Brugada Syndrome

フルテキストURL	fulltext.pdf
著者	Morimoto, Yoshimasa\| Morita, Hiroshi\| Ejiri, Kentaro\| Mizuno, Tomofumi\| Masuda, Takuro\| Ueoka, Akira\| Asada, Saori\| Miyamoto, Masakazu\| Kawada, Satoshi\| Nakagawa, Koji\| Nishii, Nobuhiro\| Nakamura, Kazufumi\| Ito, Hiroshi\|
キーワード	activation pattern body surface map Brugada syndrome complete right bundle-branch block
発行日	2023-05-16
出版物タイトル	Journal of the American Heart Association
巻	12巻
号	10号
出版者	Wiley
開始ページ	e028706
ISSN	2047-9980
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	37158059
DOI	10.1161/JAHA.122.028706
Web of Science KeyUT	001003633600014
関連URL	isVersionOf https://doi.org/10.1161/JAHA.122.028706

Endobronchial Metastasis with Bloody Sputum 20 Years after Complete Resection of type A Non-Invasive Thymoma

JaLCDOI	10.18926/AMO/65503
フルテキストURL	77_3_331.pdf
著者	Watanabe, Mototsugu\| Yamamoto, Hiromasa\| Miyoshi, Kentaroh\| Sugimoto, Seiichiro\| Toyooka, Shinichi\|
抄録	Masaoka stage I type A thymomas rarely recur. We report the case of an 82-year-old man who developed endobronchial metastasis after thymothymectomy for Masaoka stage I type A thymoma. Twenty years after surgery, the patient developed bloody sputum, and chest computed tomography revealed a neoplasm obstructing the right upper lobe bronchus of the lung with enlarged mediastinal lymph nodes. He underwent right upper lobectomy and mediastinal lymph node dissection. Although preoperative pathological diagnosis was squamous cell carcinoma of the lung, postoperative histopathology revealed endobronchial metastasis of the thymoma. Nine years later, at age 89, the patient is alive and well.
キーワード	endobronchial metastasis type A thymoma bloody sputum
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2023-06
巻	77巻
号	3号
出版者	Okayama University Medical School
開始ページ	331
終了ページ	334
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37357635
Web of Science KeyUT	001026663400001

Diagnostic Performance of Cardiac Computed Tomography for Detecting Patent Foramen Ovale: Evaluation Using Transesophageal Echocardiography and Catheterization as Reference Standards

フルテキストURL	fulltext.pdf
著者	Miki, Takashi\| Nakagawa, Koji\| Ichikawa, Keishi\| Mizuno, Tomofumi\| Nakayama, Rie\| Ejiri, Kentaro\| Kawada, Satoshi\| Takaya, Yoichi\| Miyamoto, Masakazu\| Miyoshi, Toru\| Akagi, Teiji\| Ito, Hiroshi\|
キーワード	patent foramen ovale cardiac computed tomography transesophageal echocardiography catheterization channel-like appearance channel-like appearance with contrast jet flow
発行日	2023-04-26
出版物タイトル	Journal of Cardiovascular Development and Disease
巻	10巻
号	5号
出版者	MDPI
開始ページ	193
ISSN	2308-3425
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	37233160
DOI	10.3390/jcdd10050193
Web of Science KeyUT	000997040200001
関連URL	isVersionOf https://doi.org/10.3390/jcdd10050193