start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=23 article-no= start-page=235104 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250617 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Imaging valley-vortex edge modes in a phononic crystal at ultrahigh frequencies en-subtitle= kn-subtitle= en-abstract= kn-abstract=We perform optical measurements and numerical simulations of guided phonon propagation in novel topological phononic crystal structures at ultrahigh frequencies. The structures support valley-polarized states that exhibit an energy vortex nature and propagate with high efficiency at domain boundaries because backscattering is suppressed due to conservation of time reversal symmetry. We extract frequency- and time-resolved spatial mode patterns and k-space images, together with dispersion relations. We investigate the conditions required for robust propagation along interfaces and thereby observe very high efficiency waveguiding. en-copyright= kn-copyright= en-aut-name=OtsukaP. H. en-aut-sei=Otsuka en-aut-mei=P. H. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TomodaM. en-aut-sei=Tomoda en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HatanakaD. en-aut-sei=Hatanaka en-aut-mei=D. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamaguchiH. en-aut-sei=Yamaguchi en-aut-mei=H. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsurutaK. en-aut-sei=Tsuruta en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsudaO. en-aut-sei=Matsuda en-aut-mei=O. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Division of Applied Physics, Graduate School of Engineering, Hokkaido University kn-affil= affil-num=2 en-affil=Division of Applied Physics, Graduate School of Engineering, Hokkaido University kn-affil= affil-num=3 en-affil=NTT Basic Research Laboratories, NTT Corporation kn-affil= affil-num=4 en-affil=NTT Basic Research Laboratories, NTT Corporation kn-affil= affil-num=5 en-affil=Department of Electrical and Electronic Engineering, Okayama University kn-affil= affil-num=6 en-affil=Division of Applied Physics, Graduate School of Engineering, Hokkaido University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=39 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 28th Japanese Telemedicine and Telecare Association kn-title=‘æ28‰ñ“ú–{‰“Šuˆã—Êw‰ïŠwp‘å‰ïŠJÕñ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KasaharaShingo en-aut-sei=Kasahara en-aut-mei=Shingo kn-aut-name=Š}Œ´^Œå kn-aut-sei=Š}Œ´ kn-aut-mei=^Œå aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Cardiovascular Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òŠwˆæ@S‘ŸŒŒŠÇŠO‰ÈŠw END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=36 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 62nd Annual Meeting of Japan Society of Clinical Oncology kn-title=‘æ62‰ñ“ú–{ŠàŽ¡—Êw‰ïŠwpW‰ïŠw‰ï•ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=“¡Œ´r‹` kn-aut-sei=“¡Œ´ kn-aut-mei=r‹` aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òŠwˆæ@Á‰»ŠíŠO‰ÈŠw END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=33 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Treatment of dementia kn-title=”F’mÇŽ¡—à en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakenoshitaShintaro en-aut-sei=Takenoshita en-aut-mei=Shintaro kn-aut-name=’|”V‰ºT‘¾˜Y kn-aut-sei=’|”V‰º kn-aut-mei=T‘¾˜Y aut-affil-num=1 ORCID= en-aut-name=TeradaSeishi en-aut-sei=Terada en-aut-mei=Seishi kn-aut-name=Ž›“c®Ži kn-aut-sei=Ž›“c kn-aut-mei=®Ži aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Neuropsychiatry, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@¸_‰È_Œo‰È affil-num=2 en-affil=Department of Neuropsychiatry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òŠwˆæ@¸__Œo•a‘ÔŠw END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=30 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (62. Drug interactions of potassium absorption agents) kn-title=–ò•¨‘ŠŒÝì—pi62\ƒJƒŠƒEƒ€‹z’…–ò‚Ì–ò•¨‘ŠŒÝì—pj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ArikiSaori en-aut-sei=Ariki en-aut-mei=Saori kn-aut-name=—L–عD kn-aut-sei=—L–Ø kn-aut-mei=¹D aut-affil-num=1 ORCID= en-aut-name=HamanoHirofumi en-aut-sei=Hamano en-aut-mei=Hirofumi kn-aut-name=à_–ì—TÍ kn-aut-sei=à_–ì kn-aut-mei=—TÍ aut-affil-num=2 ORCID= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=ÀŠÔ–¡‹`l kn-aut-sei=ÀŠÔ–¡ kn-aut-mei=‹`l aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Pharmacy, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@–òÜ•” affil-num=2 en-affil=Department of Pharmacy, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@–òÜ•” affil-num=3 en-affil=Department of Pharmacy, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@–òÜ•” END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=25 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The advances in robot-assisted surgery in the field of urology and future perspective kn-title=”å”AŠí‰È—̈æ‚É‚¨‚¯‚郃{ƒbƒgŽèp‚Ìi‰»‚Æ–¢—ˆ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=BekkuKensuke en-aut-sei=Bekku en-aut-mei=Kensuke kn-aut-name=•Ê‹{Œª‰î kn-aut-sei=•Ê‹{ kn-aut-mei=Œª‰î aut-affil-num=1 ORCID= en-aut-name=NagasakiNaoya en-aut-sei=Nagasaki en-aut-mei=Naoya kn-aut-name=’·ú±’¼–ç kn-aut-sei=’·ú± kn-aut-mei=’¼–ç aut-affil-num=2 ORCID= en-aut-name=OkamotoYusuke en-aut-sei=Okamoto en-aut-mei=Yusuke kn-aut-name=‰ª–{—I—C kn-aut-sei=‰ª–{ kn-aut-mei=—I—C aut-affil-num=3 ORCID= en-aut-name=ShiraishiHiromasa en-aut-sei=Shiraishi en-aut-mei=Hiromasa kn-aut-name=”’ΗT‰ë kn-aut-sei=”’Î kn-aut-mei=—T‰ë aut-affil-num=4 ORCID= en-aut-name=TairaAya en-aut-sei=Taira en-aut-mei=Aya kn-aut-name=•½—ÇÊ kn-aut-sei=•½—Ç kn-aut-mei=Ê aut-affil-num=5 ORCID= en-aut-name=InoueShota en-aut-sei=Inoue en-aut-mei=Shota kn-aut-name=ˆäããÄ‘¾ kn-aut-sei=ˆäã kn-aut-mei=ãÄ‘¾ aut-affil-num=6 ORCID= en-aut-name=KawagoYuya en-aut-sei=Kawago en-aut-mei=Yuya kn-aut-name=쇗T–ç kn-aut-sei=ì‡ kn-aut-mei=—T–ç aut-affil-num=7 ORCID= en-aut-name=WatanabeTomofumi en-aut-sei=Watanabe en-aut-mei=Tomofumi kn-aut-name=“n•”’q•¶ kn-aut-sei=“n•” kn-aut-mei=’q•¶ aut-affil-num=8 ORCID= en-aut-name=MitsuiMasao en-aut-sei=Mitsui en-aut-mei=Masao kn-aut-name=ŽOˆä›’—Y kn-aut-sei=ŽOˆä kn-aut-mei=›’—Y aut-affil-num=9 ORCID= en-aut-name=HoriiSatoshi en-aut-sei=Horii en-aut-mei=Satoshi kn-aut-name=–xˆä‘ kn-aut-sei=–xˆä kn-aut-mei=‘ aut-affil-num=10 ORCID= en-aut-name=MoriwakeTakatoshi en-aut-sei=Moriwake en-aut-mei=Takatoshi kn-aut-name=X•ª‹Mr kn-aut-sei=X•ª kn-aut-mei=‹Mr aut-affil-num=11 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name=‹g‰iŸ kn-aut-sei=‹g‰i kn-aut-mei=Ÿ aut-affil-num=12 ORCID= en-aut-name=MitsuiYosuke en-aut-sei=Mitsui en-aut-mei=Yosuke kn-aut-name=Œõˆä—m‰î kn-aut-sei=Œõˆä kn-aut-mei=—m‰î aut-affil-num=13 ORCID= en-aut-name=YamanoiTomoaki en-aut-sei=Yamanoi en-aut-mei=Tomoaki kn-aut-name=ŽR–ìˆä—Fº kn-aut-sei=ŽR–ìˆä kn-aut-mei=—Fº aut-affil-num=14 ORCID= en-aut-name=KawadaTatsushi en-aut-sei=Kawada en-aut-mei=Tatsushi kn-aut-name=‰Í“c’BŽu kn-aut-sei=‰Í“c kn-aut-mei=’BŽu aut-affil-num=15 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name=’蕽‘ì–ç kn-aut-sei=’蕽 kn-aut-mei=‘ì–ç aut-affil-num=16 ORCID= en-aut-name=TominagaYusuke en-aut-sei=Tominaga en-aut-mei=Yusuke kn-aut-name=•x‰i—I‰î kn-aut-sei=•x‰i kn-aut-mei=—I‰î aut-affil-num=17 ORCID= en-aut-name=IwataTakehiro en-aut-sei=Iwata en-aut-mei=Takehiro kn-aut-name=Šâ“cŒ’G kn-aut-sei=Šâ“c kn-aut-mei=Œ’G aut-affil-num=18 ORCID= en-aut-name=KatayamaSatoshi en-aut-sei=Katayama en-aut-mei=Satoshi kn-aut-name=•ÐŽR‘ kn-aut-sei=•ÐŽR kn-aut-mei=‘ aut-affil-num=19 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name=¼‘ºTŒá kn-aut-sei=¼‘º kn-aut-mei=TŒá aut-affil-num=20 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name=Ž}‘ºN•½ kn-aut-sei=Ž}‘º kn-aut-mei=N•½ aut-affil-num=21 ORCID= en-aut-name=KobayashiTomoko en-aut-sei=Kobayashi en-aut-mei=Tomoko kn-aut-name=¬—Ñ’mŽq kn-aut-sei=¬—Ñ kn-aut-mei=’mŽq aut-affil-num=22 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name=r–ØŒ³˜N kn-aut-sei=r–Ø kn-aut-mei=Œ³˜N aut-affil-num=23 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=2 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=3 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=4 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=5 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=6 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=7 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=10 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=11 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=12 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=13 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=14 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=15 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=16 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=17 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=18 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=19 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=20 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=21 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=22 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=23 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw en-keyword=ƒƒ{ƒbƒgŽèp kn-keyword=ƒƒ{ƒbƒgŽèp en-keyword=ƒ_ƒrƒ“ƒ` kn-keyword=ƒ_ƒrƒ“ƒ` en-keyword=”å”AŠí‰È—̈æ kn-keyword=”å”AŠí‰È—̈æ END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=20 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Questionnaire survey of junior and mid-career otolaryngologists' attitudes towards clinical research kn-title=ŽáŽèE’†Œ˜Ž¨•@ˆôA‰ÈˆãŽt‚Ì—Õ°Œ¤‹†‚ɑ΂·‚鎿–⎆’²¸ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@Introduction : Clinical research is crucial for the advancement of medicine, but modern otolaryngologists' attitudes regarding clinical research have not been known. This study was conducted to survey the background, knowledge, and interest in clinical research among junior and mid-career otolaryngologists.
@Methods : A questionnaire survey was distributed to 34 otolaryngologists with ?15 years' clinical experience working at Okayama University and its affiliated facilities. The respondents were divided into junior (non-specialists) and mid-career otolaryngologists (specialists) based on whether they were board-certified otolaryngologists. The survey assessed their background, understanding, and interest in clinical research.
@Results : Twenty-nine otolaryngologists (83%) responded (10 junior and 19 mid-career otolaryngologists). There was significant individual variation in their interest and knowledge of clinical research. However, approximately half of the respondents indicated that they were not interested in and/or had never engaged in clinical research.
@Conclusion : The data collected by this survey contribute to our understanding of the current state of clinical research engagement among junior and mid-career otolaryngologists, and they can serve as a basis for exploring future strategies to increase this engagement. en-copyright= kn-copyright= en-aut-name=UraguchiKensuke en-aut-sei=Uraguchi en-aut-mei=Kensuke kn-aut-name=‰YŒûŒ’‰î kn-aut-sei=‰YŒû kn-aut-mei=Œ’‰î aut-affil-num=1 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name=—Š“¡‹MŽu kn-aut-sei=—Š“¡ kn-aut-mei=‹MŽu aut-affil-num=2 ORCID= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name=‚”ö‘Ži kn-aut-sei=‚”ö kn-aut-mei=‘Ži aut-affil-num=3 ORCID= en-aut-name=SugayaAkiko en-aut-sei=Sugaya en-aut-mei=Akiko kn-aut-name=›’J–¾Žq kn-aut-sei=›’J kn-aut-mei=–¾Žq aut-affil-num=4 ORCID= en-aut-name=AndoMizuo en-aut-sei=Ando en-aut-mei=Mizuo kn-aut-name=ˆÀ“¡¶ kn-aut-sei=ˆÀ“¡ kn-aut-mei=¶ aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@‰uŠwE‰q¶Šw affil-num=2 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@‰uŠwE‰q¶Šw affil-num=3 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@‰uŠwE‰q¶Šw affil-num=4 en-affil=Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òŠwˆæ@Ž¨•@ˆôAE“ªèò•”ŠO‰ÈŠw affil-num=5 en-affil=Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òŠwˆæ@Ž¨•@ˆôAE“ªèò•”ŠO‰ÈŠw en-keyword=—Õ°Œ¤‹† (clinical research) kn-keyword=—Õ°Œ¤‹† (clinical research) en-keyword=“Œv‰ðÍ (statistical analysis) kn-keyword=“Œv‰ðÍ (statistical analysis) en-keyword=ƒrƒbƒOƒf[ƒ^ (bigdata) kn-keyword=ƒrƒbƒOƒf[ƒ^ (bigdata) en-keyword=Ž¿–⎆’²¸ (questionnaire survey) kn-keyword=Ž¿–⎆’²¸ (questionnaire survey) END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=15 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The potential and prospects of organ generation medicine kn-title=‘ŸŠí‘n‘¢EˆÚAˆã—Ẩ”\«‚Æ“W–] en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MoriMunemasa en-aut-sei=Mori en-aut-mei=Munemasa kn-aut-name=X@¹ kn-aut-sei=X kn-aut-mei=@¹ aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Organ Generation and Biomedical Engineering, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òˆæ@‘ŸŠí‘n‘¢ˆã—ÃE¶–½ˆãHŠw en-keyword=organ generation kn-keyword=organ generation en-keyword=regeneration kn-keyword=regeneration en-keyword=bioengineering kn-keyword=bioengineering END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=10 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Understanding the pathogenesis of rare monogenic disorders and the social implementation of genomic medicine kn-title=V¶Ž™ŠúE¬Ž™”­Ç‚ÌŠó­ˆâ“`«Ž¾Š³‚Ì•a‘ԉ𖾂ƃQƒmƒ€‰ð͂̎ЉïŽÀ‘•‚ÉŒü‚¯‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakenouchiToshiki en-aut-sei=Takenouchi en-aut-mei=Toshiki kn-aut-name=•“àrŽ÷ kn-aut-sei=•“à kn-aut-mei=rŽ÷ aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Pediatric Neurology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òŠwˆæ@¬Ž™”­’B•aˆö•a‘ÔŠw en-keyword=•a‘ԉ𖾠kn-keyword=•a‘ԉ𖾠en-keyword=Šó­ˆâ“`«Ž¾Š³ kn-keyword=Šó­ˆâ“`«Ž¾Š³ en-keyword=ŽÐ‰ïŽÀ‘• kn-keyword=ŽÐ‰ïŽÀ‘• END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=7 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2023 Incentive Award of the Okayama Medical Association in Cancer Research (2023 Hayashibara Prize and Yamada Prize) kn-title=—ߘa‚T”N“x‰ªŽRˆãŠw‰ïÜ@‚ª‚ñŒ¤‹†§—ãÜi—ÑŒ´ÜEŽR“cÜj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UrataTomohiro en-aut-sei=Urata en-aut-mei=Tomohiro kn-aut-name=‰Y“c’mG kn-aut-sei=‰Y“c kn-aut-mei=’mG aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È ŒŒ‰tEŽîá‡EŒÄ‹zŠí“à‰ÈŠw END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=4 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2023 Incentive Award of the Okayama Medical Association in General Medical Science (2023 Yuuki Prize) kn-title=—ߘa‚T”N“x‰ªŽRˆãŠw‰ïÜ@‘‡Œ¤‹†§—ãÜiŒ‹éÜj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SumiiYuichi en-aut-sei=Sumii en-aut-mei=Yuichi kn-aut-name=Z‹—Dˆê kn-aut-sei=Z‹ kn-aut-mei=—Dˆê aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@ŒŒ‰tEŽîá‡EŒÄ‹zŠí“à‰ÈŠw END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=1 end-page=3 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2023 Incentive Award of the Okayama Medical Association in Neuroscience (2023 Niimi Prize) kn-title=—ߘa‚T”N“x‰ªŽRˆãŠw‰ïÜ@”]_ŒoŒ¤‹†§—ãÜiVŒ©Üj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakenoshitaShintaro en-aut-sei=Takenoshita en-aut-mei=Shintaro kn-aut-name=’|”V‰ºT‘¾˜Y kn-aut-sei=’|”V‰º kn-aut-mei=T‘¾˜Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@¸__Œo•a‘ÔŠw END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=2 article-no= start-page=135 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Calcified Amorphous Tumor of the Left Ventricle with Paroxysmal Atrial Fibrillation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cardiac calcified amorphous tumor (CAT) is a rare, benign non-neoplastic mass of the heart that is sometimes found due to embolic events. Most cases of CAT are treated with surgical removal to prevent future embolic events. However, the treatment strategy for CAT complicated by atrial fibrillation has remained to be determined. Here we report a case of left ventricular CAT complicated by paroxysmal atrial fibrillation (PAF) that was successfully treated with surgical removal and pulmonary vein isolation. Pulmonary vein isolation can be a simple and effective procedure for PAF, even during surgical removal of CAT. en-copyright= kn-copyright= en-aut-name=FujitaYasufumi en-aut-sei=Fujita en-aut-mei=Yasufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimizuShuji en-aut-sei=Shimizu en-aut-mei=Shuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MohriMakoto en-aut-sei=Mohri en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Cardiovascular Surgery, Kure Kyosai Hospital kn-affil= affil-num=2 en-affil=Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Cardiovascular Surgery, Japanese Red Cross Society Himeji Hospital kn-affil= en-keyword=calcified amorphous tumor kn-keyword=calcified amorphous tumor en-keyword=surgical removal kn-keyword=surgical removal en-keyword=embolic stroke kn-keyword=embolic stroke en-keyword=paroxysmal atrial fibrillation kn-keyword=paroxysmal atrial fibrillation en-keyword=pulmonary vein isolation kn-keyword=pulmonary vein isolation END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=2 article-no= start-page=129 end-page=134 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Case of Retinitis Pigmentosa Diagnosed with Severe Anterior Capsule Contraction after Cataract Surgery en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 66-year-old woman presented with significant anterior capsule contraction and intraocular lens dislocation in both eyes 4 months after cataract surgery. Postoperative examinations such as fluorescein angiography, Goldmann perimetry, and electroretinography revealed retinitis pigmentosa (RP). Patients with significant anterior capsule contraction after cataract surgery should be closely examined because RP may be a contributing factor. en-copyright= kn-copyright= en-aut-name=TsujiAkihiro en-aut-sei=Tsuji en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShiodeYusuke en-aut-sei=Shiode en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimuraShuhei en-aut-sei=Kimura en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HosokawaMio en-aut-sei=Hosokawa en-aut-mei=Mio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatobaRyo en-aut-sei=Matoba en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MoritaTetsuro en-aut-sei=Morita en-aut-mei=Tetsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakahashiKosuke en-aut-sei=Takahashi en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MorizaneYuki en-aut-sei=Morizane en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Fukuyama City Hospital, Fukuyama City kn-affil= affil-num=8 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=retinitis pigmentosa kn-keyword=retinitis pigmentosa en-keyword=intraocular lens kn-keyword=intraocular lens en-keyword=anterior capsule contraction kn-keyword=anterior capsule contraction END start-ver=1.4 cd-journal=joma no-vol=213 cd-vols= no-issue= article-no= start-page=128 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The potential mechanism maintaining transactive response DNA binding protein 43?kDa in the mouse stroke model en-subtitle= kn-subtitle= en-abstract= kn-abstract=The disruption of transactive response DNA binding protein 43?kDa (TDP-43) shuttling leads to the depletion of nuclear localization and the cytoplasmic accumulation of TDP-43. We aimed to evaluate the mechanism underlying the behavior of TDP-43 in ischemic stroke. Adult male C57BL/6?J mice were subjected to 30 or 60?min of transient middle cerebral artery occlusion (tMCAO), and examined at 1, 6, and 24?h post reperfusion. Immunostaining was used to evaluate the expression of TDP-43, G3BP1, HDAC6, and RAD23B. The total and cytoplasmic number of TDP-43?positive cells increased compared with sham operation group and peaked at 6?h post reperfusion after tMCAO. The elevated expression of G3BP1 protein peaked at 6?h after reperfusion and decreased at 24?h after reperfusion in ischemic mice brains. We also observed an increase of expression level of HDAC6 and the number of RAD23B-positive cells increased after tMCAO. RAD23B was colocalized with TDP-43 24?h after tMCAO. We proposed that the formation of stress granules might be involved in the mislocalization of TDP-43, based on an evaluation of G3BP1 and HDAC6. Subsequently, RAD23B, may also contribute to the downstream degradation of mislocalized TDP-43 in mice tMCAO model. en-copyright= kn-copyright= en-aut-name=BianYuting en-aut-sei=Bian en-aut-mei=Yuting kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Ota-ElliottRicardo Satoshi en-aut-sei=Ota-Elliott en-aut-mei=Ricardo Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HuXinran en-aut-sei=Hu en-aut-mei=Xinran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SunHongming en-aut-sei=Sun en-aut-mei=Hongming kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=BianZhihong en-aut-sei=Bian en-aut-mei=Zhihong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ZhaiYun en-aut-sei=Zhai en-aut-mei=Yun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YuHaibo en-aut-sei=Yu en-aut-mei=Haibo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HuXiao en-aut-sei=Hu en-aut-mei=Xiao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=AnHangping en-aut-sei=An en-aut-mei=Hangping kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=LiuHongzhi en-aut-sei=Liu en-aut-mei=Hongzhi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IshiuraHiroyuki en-aut-sei=Ishiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=TDP-43 kn-keyword=TDP-43 en-keyword=ALS kn-keyword=ALS en-keyword=RNA-binding protein kn-keyword=RNA-binding protein en-keyword=Mislocalization kn-keyword=Mislocalization en-keyword=G3BP1 kn-keyword=G3BP1 en-keyword=HDAC6 kn-keyword=HDAC6 en-keyword=RAD23B kn-keyword=RAD23B en-keyword=tMCAO kn-keyword=tMCAO END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=2 article-no= start-page=129 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230414 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Disease and Injury Trends following Heavy Rains in Western Japan in 2018 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Introduction: Torrential rains occurred in Okayama in western Japan in July 2018, forcing local residents to evacuate. Few studies have reported early-phase disease and injury trends among patients following torrential rains. Thus, in this study, we assessed the illness and injury trends among patients who visited temporary medical facilities located in the areas affected by the 2018 torrential rains; these facilities opened 10 d after the disaster.
Methods: We evaluated the trends among patients who visited a medical clinic located in the area in western Japan affected by heavy rains in 2018. We reviewed medical charts related to 1,301 outpatient visits and conducted descriptive analyses.
Results: More than half of the patients were over 60 years old. The patients experienced mild injuries (7.9% of total visits) as well as common diseases such as hypertensive diseases (30%), diabetes mellitus (7.8%), acute upper respiratory infections (5.4%), skin diseases (5.4%), and eye diseases (4.8%). Hypertensive diseases were the main cause of a visit in any week. Eye problems were the second-highest reason for a visit in the first week, but there was a relative decrease from the first to the third week. Additionally, the proportion of injuries and skin diseases increased from the first to the second week, from 7.9% to 11.1% for injuries, and from 3.9% to 6.7% for skin diseases.
Conclusions: The types of diseases changed on a weekly basis. Older adults needed medical support for longer than other age groups. Prior preparedness such as earlier deployment of such temporary clinics can help mitigate the damage to the victims. en-copyright= kn-copyright= en-aut-name=HashimotoChiaki en-aut-sei=Hashimoto en-aut-mei=Chiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MurakamiKazuharu en-aut-sei=Murakami en-aut-mei=Kazuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuganamiShigeru en-aut-sei=Suganami en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Epidemiology, Graduate School of Medicine, Density and Pharmaceutical Sciences Okayama University kn-affil= affil-num=2 en-affil=Department of Epidemiology, Graduate School of Medicine, Density and Pharmaceutical Sciences Okayama University kn-affil= affil-num=3 en-affil=Mabi Memorial Hospital kn-affil= affil-num=4 en-affil=Association of Medical Doctors of Asia kn-affil= en-keyword=Common disease kn-keyword=Common disease en-keyword=communicable disease control kn-keyword=communicable disease control en-keyword=disaster kn-keyword=disaster en-keyword=flood kn-keyword=flood en-keyword=heavy rains kn-keyword=heavy rains en-keyword=Okayama kn-keyword=Okayama END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=5 article-no= start-page=363 end-page=370 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Small-for-Gestational-Age Status and the Risk of Kawasaki Disease: A Nationwide Birth Cohort in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a nationwide Japanese birth cohort study conducted in 2010 (n=34,579), we investigated whether SGA increases the risk of KD. SGA was defined as birth weight below the 10th percentile for gestational age. The outcome was hospitalization for KD between 6 and 30 months of age. The association between SGA and hospitalization for KD, adjusted for child and maternal factors, was examined using logistic regression. Of the 231 children hospitalized for KD, 9.5% were SGA. Further statistical analysis showed that SGA did not increase the odds ratio (OR) of hospitalization for KD (adjusted OR 1.12, 95% confidence interval 0.71-1.75). This result was not changed with stratification by early daycare attendance and preterm status. Reasons for the lack of association may include the multifactorial pathogenesis of KD; in addition, the types of infections to which SGA infants are predisposed may differ from those triggering KD. Overall, our large nationwide study found no association between SGA and KD. en-copyright= kn-copyright= en-aut-name=TakanagaSatoe en-aut-sei=Takanaga en-aut-mei=Satoe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoNaomi en-aut-sei=Matsumoto en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KadowakiTomoka en-aut-sei=Kadowaki en-aut-mei=Tomoka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Kawasaki disease (KD) kn-keyword=Kawasaki disease (KD) en-keyword=small for gestational age (SGA) kn-keyword=small for gestational age (SGA) en-keyword=cohort kn-keyword=cohort en-keyword=epidemiology kn-keyword=epidemiology END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=9 article-no= start-page=212 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mutations in starch BRANCHING ENZYME 2a suppress the traits caused by the loss of ISOAMYLASE1 in barley en-subtitle= kn-subtitle= en-abstract= kn-abstract=The genetic interactions among starch biosynthesis genes can be exploited to alter starch properties, but they remain poorly understood due to the various combinations of mutations to be tested. Here, we isolated two novel barley mutants defective in starch BRANCHING ENZYME 2a (hvbe2a-1 and hvbe2a-2) based on the starch granule (SG) morphology. Both hvbe2a mutants showed elongated SGs in the endosperm and increased resistant starch content. hvbe2a-1 had a base change in HvBE2a gene, substituting the amino acid essential for its enzyme activity, while hvbe2a-2 is completely missing HvBE2a due to a chromosomal deletion. Further genetic crosses with barley isoamylase1 mutants (hvisa1) revealed that both hvbe2a mutations could suppress defects in endosperm caused by hvisa1, such as reduction in starch, increase in phytoglycogen, and changes in the glucan chain length distribution. Remarkably, hvbe2a mutations also transformed the endosperm SG morphology from the compound SG caused by hvisa1 to bimodal simple SGs, resembling that of wild-type barley. The suppressive impact was in competition with floury endosperm 6 mutation (hvflo6), which could enhance the phenotype of hvisa1 in the endosperm. In contrast, the compound SG formation induced by the hvflo6 hvisa1 mutation in pollen was not suppressed by hvbe2a mutations. Our findings provide new insights into genetic interactions in the starch biosynthetic pathway, demonstrating how specific genetic alterations can influence starch properties and SG morphology, with potential applications in cereal breeding for desired starch properties. en-copyright= kn-copyright= en-aut-name=MatsushimaRyo en-aut-sei=Matsushima en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HisanoHiroshi en-aut-sei=Hisano en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimJune-Sik en-aut-sei=Kim en-aut-mei=June-Sik kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=McNellyRose en-aut-sei=McNelly en-aut-mei=Rose kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OitomeNaoko F. en-aut-sei=Oitome en-aut-mei=Naoko F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SeungDavid en-aut-sei=Seung en-aut-mei=David kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FujitaNaoko en-aut-sei=Fujita en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SatoKazuhiro en-aut-sei=Sato en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=2 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=3 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=4 en-affil=John Innes Centre, Norwich Research Park kn-affil= affil-num=5 en-affil=Department of Biological Production, Akita Prefectural University kn-affil= affil-num=6 en-affil=John Innes Centre, Norwich Research Park kn-affil= affil-num=7 en-affil=Department of Biological Production, Akita Prefectural University kn-affil= affil-num=8 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=11 article-no= start-page=jcs261977 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Toxicity of the model protein 3~GFP arises from degradation overload, not from aggregate formation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although protein aggregation can cause cytotoxicity, such aggregates can also form to mitigate cytotoxicity from misfolded proteins, although the nature of these contrasting aggregates remains unclear. We previously found that overproduction (op) of a three green fluorescent protein-linked protein (3~GFP) induces giant aggregates and is detrimental to growth. Here, we investigated the mechanism of growth inhibition by 3~GFP-op using non-aggregative 3~MOX-op as a control in Saccharomyces cerevisiae. The 3~GFP aggregates were induced by misfolding, and 3~GFP-op had higher cytotoxicity than 3~MOX-op because it perturbed the ubiquitin-proteasome system. Static aggregates formed by 3~GFP-op dynamically trapped Hsp70 family proteins (Ssa1 and Ssa2 in yeast), causing the heat-shock response. Systematic analysis of mutants deficient in the protein quality control suggested that 3~GFP-op did not cause a critical Hsp70 depletion and aggregation functioned in the direction of mitigating toxicity. Artificial trapping of essential cell cycle regulators into 3~GFP aggregates caused abnormalities in the cell cycle. In conclusion, the formation of the giant 3~GFP aggregates itself is not cytotoxic, as it does not entrap and deplete essential proteins. Rather, it is productive, inducing the heat-shock response while preventing an overload to the degradation system. en-copyright= kn-copyright= en-aut-name=NambaShotaro en-aut-sei=Namba en-aut-mei=Shotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MoriyaHisao en-aut-sei=Moriya en-aut-mei=Hisao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Aggregation kn-keyword=Aggregation en-keyword=Fluorescent protein kn-keyword=Fluorescent protein en-keyword=Hsp70 kn-keyword=Hsp70 en-keyword=Overproduction kn-keyword=Overproduction en-keyword=Toxicity kn-keyword=Toxicity en-keyword=Yeast kn-keyword=Yeast END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=3 article-no= start-page=285 end-page=290 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Organized Chronic Subdural Hematoma (OCSDH) Mimicking Meningioma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Organized chronic subdural hematoma (OCSDH) is a relatively rare condition that forms over a longer period of time compared to chronic subdural hematoma and is sometimes difficult to diagnose with preoperative imaging. We resected an intracranial lesion in a 37-year-old Japanese man; the lesion had been increasing in size for >17 years. The preoperative diagnosis based on imaging findings was meningioma; however, pathological findings revealed OCSDH. Clinicians should be aware that OCSDH mimics other tumors and consider surgical strategies for this disease. en-copyright= kn-copyright= en-aut-name=HiranoShuichiro en-aut-sei=Hirano en-aut-mei=Shuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtaniYoshihiro en-aut-sei=Otani en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiiKentaro en-aut-sei=Fujii en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DateIsao en-aut-sei=Date en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=meningioma kn-keyword=meningioma en-keyword=organized chronic subdural hematoma kn-keyword=organized chronic subdural hematoma END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=2 article-no= start-page=193 end-page=196 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Laparoscopic Resection Combined with a Transsacral Approach for a Recurrent Tailgut Cyst with a Refractory Fistula en-subtitle= kn-subtitle= en-abstract= kn-abstract=Tailgut cyst is a rare cystic disease of the anterior sacral surface and the remains of an embryonic tail gut. Tailgut cysts have a potential for malignancy, and complete resection with an adequate surgical margin is necessary. Even if incomplete resection does not result in recurrence of malignant disease, there is a risk of local infection leading to refractory fistulas. The optimal treatment for such refractory recurrent lesions has not been reported. We describe a case in which the combination of laparoscopic and transsacral approaches was effective for resecting a recurrent refractory fistula after incomplete resection of a tail gut cyst. en-copyright= kn-copyright= en-aut-name=KashimaHajime en-aut-sei=Kashima en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TeraishiFuminori en-aut-sei=Teraishi en-aut-mei=Fuminori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsumiYuki en-aut-sei=Matsumi en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShimamuraHiroshi en-aut-sei=Shimamura en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Surgery, Chikuba Hospital for Gastrointestinal and Colorectal Surgery kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=tailgut cyst kn-keyword=tailgut cyst en-keyword=laparoscopic resection kn-keyword=laparoscopic resection en-keyword=fistula formation kn-keyword=fistula formation END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=2 article-no= start-page=123 end-page=134 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sigle Agent of Posttransplant Cyclophosphamide Without Calcineurin Inhibitor Controls Severity of Experimental Chronic GVHD en-subtitle= kn-subtitle= en-abstract= kn-abstract=Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. en-copyright= kn-copyright= en-aut-name=SaekiKyosuke en-aut-sei=Saeki en-aut-mei=Kyosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiwaraHideaki en-aut-sei=Fujiwara en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SeikeKeisuke en-aut-sei=Seike en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KuroiTaiga en-aut-sei=Kuroi en-aut-mei=Taiga kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsuokaKen-ichi en-aut-sei=Matsuoka en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujiiNobuharu en-aut-sei=Fujii en-aut-mei=Nobuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Division of Transfusion, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=GVHD kn-keyword=GVHD en-keyword=posttransplant cyclophosphamide kn-keyword=posttransplant cyclophosphamide en-keyword=hematopoietic cell transplantation kn-keyword=hematopoietic cell transplantation en-keyword=HLA-identical kn-keyword=HLA-identical END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=1 article-no= start-page=85 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential efficacy of TM in treating IPUD and the importance of considering hypercontractility as the underlying cause in cases of IPUD. en-copyright= kn-copyright= en-aut-name=MiyakeKeisuke en-aut-sei=Miyake en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanikawaTomohiro en-aut-sei=Tanikawa en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HarumaKen en-aut-sei=Haruma en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KawadaMayuko en-aut-sei=Kawada en-aut-mei=Mayuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IshiiKatsunori en-aut-sei=Ishii en-aut-mei=Katsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UrataNoriyo en-aut-sei=Urata en-aut-mei=Noriyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishinoKen en-aut-sei=Nishino en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SuehiroMitsuhiko en-aut-sei=Suehiro en-aut-mei=Mitsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KawanakaMiwa en-aut-sei=Kawanaka en-aut-mei=Miwa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ManabeNoriaki en-aut-sei=Manabe en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KawamotoHirofumi en-aut-sei=Kawamoto en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Post graduate clinical education center, Kawasaki Medical School General Medical Center kn-affil= affil-num=2 en-affil=Department of General Internal Medicine 2, Kawasaki Medical School kn-affil= affil-num=3 en-affil=Department of General Internal Medicine 2, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of General Internal Medicine 2, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of General Internal Medicine 2, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of General Internal Medicine 2, Kawasaki Medical School kn-affil= affil-num=7 en-affil=Department of General Internal Medicine 2, Kawasaki Medical School kn-affil= affil-num=8 en-affil=Department of General Internal Medicine 2, Kawasaki Medical School kn-affil= affil-num=9 en-affil=Department of General Internal Medicine 2, Kawasaki Medical School kn-affil= affil-num=10 en-affil=Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School kn-affil= affil-num=11 en-affil=Department of General Internal Medicine 2, Kawasaki Medical School kn-affil= en-keyword=gastric ulcer kn-keyword=gastric ulcer en-keyword=idiopathic peptic ulcerative disease kn-keyword=idiopathic peptic ulcerative disease en-keyword=trimebutine maleate kn-keyword=trimebutine maleate END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=6 article-no= start-page=577 end-page=587 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Japanese Nursing Stafffs Knowledge and Attitude toward Bereavement Care for Couples with Miscarriage/Stillbirth and Its Associated Factors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bereavement care is conducted to meet the emotional needs of grieving couples who are devastated by the experience of a miscarriage or stillbirth. From January to April 2022, we distributed a questionnaire that assessed the knowledge and attitudes of Japanese nursing staff (nurses and midwives) in Japanfs Chugoku-Shikoku region toward bereavement care for couples with miscarriage/stillbirth. The 370 survey respondentsf answers revealed that the nursing stafffs knowledge regarding recurrent pregnancy loss and subsequent bereavement care was insufficient. About 41.1% and 64.1% of the respondents had received school and on-the-job education in bereavement care, respectively, and 79.2% expressed willingness to provide such care. Our analyses revealed that the following factors were associated with the nursing stafffs knowledge level: parent status, age, reproductive history, midwifery license, work experience and environment, and on-the-job education. The following were correlated with the stafffs willingness to provide bereavement care: work environment, midwifery license, bereavement care knowledge, and on-the-job education. Together our findings indicate that education plays a significant role in equipping caregivers to provide effective bereavement care for couples who have experienced a miscarriage or stillbirth. en-copyright= kn-copyright= en-aut-name=LiuSiyu en-aut-sei=Liu en-aut-mei=Siyu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AthurupanaRukmali en-aut-sei=Athurupana en-aut-mei=Rukmali kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HanHongmei en-aut-sei=Han en-aut-mei=Hongmei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YangTiti en-aut-sei=Yang en-aut-mei=Titi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakatsukaMikiya en-aut-sei=Nakatsuka en-aut-mei=Mikiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Density and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=midwife kn-keyword=midwife en-keyword=nurse kn-keyword=nurse en-keyword=miscarriage kn-keyword=miscarriage en-keyword=bereavement kn-keyword=bereavement en-keyword=knowledge kn-keyword=knowledge END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=5 article-no= start-page=461 end-page=469 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Relationship between the Hip Abductor Muscles and Abduction Strength in Patients with Hip Osteoarthritis en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study aimed to determine which muscle the gluteus maximus, gluteus medius, gluteus minimus (Gmin), or tensor fasciae latae (TFL) contributes most to hip abduction strength and to identify effective sites for cross-sectional area (CSA) Gmin and TFL measurement in hip osteoarthritis (OAhip) patients. Twenty-eight patients with OAhip were included. The muscle CSA and volume were determined using magnetic resonance imaging. Peak isometric strength was determined using hand-held dynamometry. Muscle volumes were normalized to the total muscle volume of hip abductors. Multiple regression analysis was performed. The difference between the CSA of Gmin and TFL was calculated, and correlations with volume and muscle strength were determined. Gmin volume was related to abductor muscle strength (p=0.042). The peak CSA of the Gmin correlated with muscle volume and strength. The CSA of the TFL correlated with volume, with no difference between the CSA of the most protruding part of the lesser trochanter and peak CSA. Gmin volume was strongly related to abductor muscle strength. Peak CSA is a useful parameter for assessing the CSA of the Gmin among patients with OAhip. The CSA of the TFL should be measured at the most protruding part of the lesser trochanter. en-copyright= kn-copyright= en-aut-name=HommaDaisuke en-aut-sei=Homma en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MinatoIzumi en-aut-sei=Minato en-aut-mei=Izumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ImaiNorio en-aut-sei=Imai en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyasakaDai en-aut-sei=Miyasaka en-aut-mei=Dai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakaiYoshinori en-aut-sei=Sakai en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HorigomeYoji en-aut-sei=Horigome en-aut-mei=Yoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SuzukiHayato en-aut-sei=Suzuki en-aut-mei=Hayato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=DohmaeYoichiro en-aut-sei=Dohmae en-aut-mei=Yoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=EndoNaoto en-aut-sei=Endo en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Division of Orthopaedic Surgery, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=2 en-affil=Division of Orthopaedic Surgery, Niigata Rinko Hospital kn-affil= affil-num=3 en-affil=Division of Comprehensive Musculoskeletal Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=4 en-affil=Division of Orthopaedic Surgery, Niigata Bandai Hospital kn-affil= affil-num=5 en-affil=Division of Orthopaedic Surgery, Niigata City General Hospital kn-affil= affil-num=6 en-affil=Division of Comprehensive Musculoskeletal Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=7 en-affil=Division of Orthopaedic Surgery, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=8 en-affil=Division of Orthopaedic Surgery, Niigata Bandai Hospital kn-affil= affil-num=9 en-affil=Division of Orthopaedic Surgery, Niigata Prefectural Tsubame Rosai Hospital kn-affil= en-keyword=gluteus minimus kn-keyword=gluteus minimus en-keyword=tensor fasciae latae kn-keyword=tensor fasciae latae en-keyword=cross-sectional area kn-keyword=cross-sectional area en-keyword=muscle volume kn-keyword=muscle volume en-keyword=hip osteoarthritis kn-keyword=hip osteoarthritis END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=4 article-no= start-page=395 end-page=405 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of Tumor Necrosis Factor-Alpha with Psychopathology in Patients with Schizophrenia en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated the relationship between serum tumor necrosis factor-alpha (TNF-ƒ¿) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-ƒ¿ levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-ƒ¿ levels were detected between the patients and controls (p=0.736). TNF-ƒ¿ levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-ƒ¿ levels and the PANSS cognitive factor (ƒÏ=?0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-ƒ¿ level (beta=?0.258, t=?2.257, p=0.027). There were no significant differences in TNF-ƒ¿ levels among patients treated with different types of antipsychotics (p=0.596). TNF-ƒ¿ levels correlated positively with the age of onset (ƒÏ=0.233, p=0.027) and negatively with illness duration (ƒÏ=?0.247, p=0.019) and antipsychotic treatment duration (ƒÏ=?0.256, p=0.015). These results indicate that TNF-ƒ¿ may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia. en-copyright= kn-copyright= en-aut-name=PavlovicMarko en-aut-sei=Pavlovic en-aut-mei=Marko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=BabicDragan en-aut-sei=Babic en-aut-mei=Dragan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=RastovicPejana en-aut-sei=Rastovic en-aut-mei=Pejana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ArapovicJurica en-aut-sei=Arapovic en-aut-mei=Jurica kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MartinacMarko en-aut-sei=Martinac en-aut-mei=Marko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=JakovacSanja en-aut-sei=Jakovac en-aut-mei=Sanja kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=BarbaricRomana en-aut-sei=Barbaric en-aut-mei=Romana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=2 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=3 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=4 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=5 en-affil=Health Care Center Mostar, University of Mostar kn-affil= affil-num=6 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=7 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= en-keyword=tumor necrosis factor-alpha kn-keyword=tumor necrosis factor-alpha en-keyword=schizophrenia kn-keyword=schizophrenia en-keyword=psychopathology kn-keyword=psychopathology en-keyword=immune system kn-keyword=immune system END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ÛHáŠQ‚É‚¨‚¯‚éÖ¬ŒŒðÇðÇ: Œã‚ëŒü‚«ŠÏŽ@Œ¤‹† kn-title=Venous Thromboembolism in Eating Disorders: A Retrospective Observational Study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SENDAMayuko en-aut-sei=SENDA en-aut-mei=Mayuko kn-aut-name=ç“c^—FŽq kn-aut-sei=ç“c kn-aut-mei=^—FŽq aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=2 article-no= start-page=131 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Venous Thromboembolism in Eating Disorders: A Retrospective Observational Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eating disorders (EDs) are associated with a high mortality rate. Patients with EDs often experience severe dehydration due to food restriction and/or vomiting. Severely underweight patients are often prescribed bed rest during inpatient care to reduce their energy consumption, and they may thus develop multiple risk factors for venous thromboembolism (VTE). We compared the clinical features of ED inpatients with VTE to those of ED inpatients without VTE. Seventy-one inpatients with ED were treated at Okayama University Hospitalfs psychiatric ward in 2016-2020; five were experienced a VTE. Compared to the non-VTE group, the VTE groupfs median age and disease duration were greater and the median body mass index (BMI) was lower. The VTE groupfs D-dimer peak values were > 5 mg/L. Physical restraint and central venous catheter use were associated with VTE. Longer ED duration and lower BMI might be risk factors for VTE. To make inpatient treatment for ED safer, it is important to avoid the use of physical restraints and central venous catheters. Continuous D-dimer monitoring is necessary for the early detection of VTE in ED patients at high risk of VTE. en-copyright= kn-copyright= en-aut-name=SendaMayuko en-aut-sei=Senda en-aut-mei=Mayuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TeradaSeishi en-aut-sei=Terada en-aut-mei=Seishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraMasaki en-aut-sei=Fujiwara en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaNorihito en-aut-sei=Yamada en-aut-mei=Norihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neuropsychiatry, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=eating disorder kn-keyword=eating disorder en-keyword=anorexia nervosa kn-keyword=anorexia nervosa en-keyword=venous thromboembolism kn-keyword=venous thromboembolism en-keyword=deep vein thrombosis kn-keyword=deep vein thrombosis END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=1 article-no= start-page=21 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202302 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Analysis of Phase Angle and Balance and Gait Functions in Pre-Frail Individuals: A Cross-Sectional Observational Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=We measured the muscle mass and phase angle of each body part to evaluate the relationship between balance and gait functions in individuals with a pre-frailty status. This cross-sectional observational study determined the skeletal muscle mass-to-body weight ratio and phase angles of 21 control (robust) and 29 pre-frail subjects. Their Brief-Balance Evaluation Systems Test, Timed Up-and-Go (TUG) test, Life-Space Assessment, and Modified Fall Efficacy Scale scores plus the relationship between muscle mass, phase angle, and motor function were evaluated. In the pre-frailty group (three males, 26 females, aged 75.58}7.60 years), significant correlations were noted between the Brief-Balance Evaluation Systems Test score and lower-limb (r=0.614) and wholebody (r=0.557) phase angles, and between the TUG test score and lower-limb muscle mass-to-body weight ratio (r=?0.616), lower-limb phase angle (r=?0.616), and whole-body phase angle (r=?0.527). Evaluating the phase angle of the lower extremities of pre-frail patients and intervening accordingly may help clinicians maintain and improve these patientsf balance and gait functions. en-copyright= kn-copyright= en-aut-name=HommaDaisuke en-aut-sei=Homma en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MinatoIzumi en-aut-sei=Minato en-aut-mei=Izumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ImaiNorio en-aut-sei=Imai en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyasakaDai en-aut-sei=Miyasaka en-aut-mei=Dai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakaiYoshinori en-aut-sei=Sakai en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HorigomeYoji en-aut-sei=Horigome en-aut-mei=Yoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SuzukiHayato en-aut-sei=Suzuki en-aut-mei=Hayato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=DohmaeYoichiro en-aut-sei=Dohmae en-aut-mei=Yoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=EndoNaoto en-aut-sei=Endo en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Orthopaedic Surgery, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=2 en-affil=Division of Orthopaedic Surgery, Niigata Rinko Hospital kn-affil= affil-num=3 en-affil=Comprehensive Musculoskeletal Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=4 en-affil=Division of Orthopaedic Surgery, Niigata Bandai Hospital kn-affil= affil-num=5 en-affil=Division of Orthopaedic Surgery, Niigata City General Hospital kn-affil= affil-num=6 en-affil=Comprehensive Musculoskeletal Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=7 en-affil=Orthopaedic Surgery, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=8 en-affil=Division of Orthopaedic Surgery, Niigata Bandai Hospital kn-affil= affil-num=9 en-affil=Division of Orthopaedic Surgery, Niigata Prefectural Tsubame Rosai Hospital kn-affil= en-keyword=bioelectrical impedance analysis kn-keyword=bioelectrical impedance analysis en-keyword=motor function kn-keyword=motor function en-keyword=muscle quality kn-keyword=muscle quality en-keyword=muscle volume kn-keyword=muscle volume END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=2 article-no= start-page=137 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Greenhouse gas emissions from agricultural soil amended with kitchen compost of varying ages en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although the use of kitchen waste compost is very common, GHG emissions from soil amended with kitchen waste compost have not been studied. This study aimed to determine the effects of kitchen compost age and application rates on GHG emissions to identify optimal compost management. Soil samples mixed with kitchen waste compost at three different ages: 1 month (1M), 2 months (2M), and 3 months (3M) at two application rates (1% and 2% w/w) were incubated at 25 degrees C for 28 days under aerobic conditions. Emissions of nitrous oxide (N2O), carbon dioxide (CO2), and methane (CH4) were determined on days 3, 7, 14, 21, and 28. Results showed that N2O and CO2 emissions decreased with compost age (p < 0.05). Increased application rates of compost led to increased CO2 emissions and suppression of N2O emissions. Furthermore, CH4 was emitted from soil amended with kitchen compost even under aerobic conditions. This study suggests that 3M kitchen waste compost is optimal in terms of GHG emissions upon application to soil under aerobic conditions. en-copyright= kn-copyright= en-aut-name=ChauTran Thi Minh en-aut-sei=Chau en-aut-mei=Tran Thi Minh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SomeyaTakashi en-aut-sei=Someya en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AkaoSatoshi en-aut-sei=Akao en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraMasato en-aut-sei=Nakamura en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OritateFumiko en-aut-sei=Oritate en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SomuraHiroaki en-aut-sei=Somura en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamaneShinzo en-aut-sei=Yamane en-aut-mei=Shinzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaedaMorihiro en-aut-sei=Maeda en-aut-mei=Morihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Agriculture, Saga University kn-affil= affil-num=3 en-affil=Faculty of Science and Engineering, Doshisha University kn-affil= affil-num=4 en-affil=Institute for Rural Engineering, NARO kn-affil= affil-num=5 en-affil=Institute for Rural Engineering, NARO kn-affil= affil-num=6 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=7 en-affil=Faculty of Agriculture and Marine Science, Kochi University kn-affil= affil-num=8 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=Aerobic conditions kn-keyword=Aerobic conditions en-keyword=greenhouse gas emissions kn-keyword=greenhouse gas emissions en-keyword=kitchen waste compost kn-keyword=kitchen waste compost END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue= article-no= start-page=137 end-page=151 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20221223 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Time Attitude, Time Frequency, and Time Orientation on Depressive Tendency kn-title=ŽžŠÔ“I‘Ô“x‚¨‚æ‚ÑŽžŠÔ“I•p“xCŽžŠÔ“IŽwŒü«‚ª—}‚¤‚ÂŒXŒü‚É‹y‚Ú‚·‰e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ZhangZe en-aut-sei=Zhang en-aut-mei=Ze kn-aut-name=’£àV kn-aut-sei=’£ kn-aut-mei=àV aut-affil-num=1 ORCID= en-aut-name=HoriuchiTakashi en-aut-sei=Horiuchi en-aut-mei=Takashi kn-aut-name=–x“àF kn-aut-sei=–x“à kn-aut-mei=F aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=6 article-no= start-page=705 end-page=713 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Impact of Tofogliflozin on Physiological and Hormonal Function, Serum Electrolytes, and Cardiac Diastolic Function in Elderly Japanese Patients with Type 2 Diabetes Mellitus en-subtitle= kn-subtitle= en-abstract= kn-abstract=The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozinfs osmotic diuresis mechanism, patientsf serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (ƒÀ1=?0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/ef tended to decrease (ƒÀ1=?0.382, p=0.13, LRA). Compared to the baseline, E/ef was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/ef group (E/ef?10, n=34), E/ef decreased significantly (ƒÀ1=?0.63, p<0.05, LRA). ƒ¢E/ef was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/ef in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function. en-copyright= kn-copyright= en-aut-name=HigashikawaToshihiro en-aut-sei=Higashikawa en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ItoTomohiko en-aut-sei=Ito en-aut-mei=Tomohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MizunoTakurou en-aut-sei=Mizuno en-aut-mei=Takurou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IshigamiKeiichiro en-aut-sei=Ishigami en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KurokiKengo en-aut-sei=Kuroki en-aut-mei=Kengo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MaekawaNaoto en-aut-sei=Maekawa en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UsudaDaisuke en-aut-sei=Usuda en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IzumidaToshihide en-aut-sei=Izumida en-aut-mei=Toshihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamadaShinya en-aut-sei=Yamada en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SangenRyusho en-aut-sei=Sangen en-aut-mei=Ryusho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HamadaKazu en-aut-sei=Hamada en-aut-mei=Kazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KiyosawaJun en-aut-sei=Kiyosawa en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=SaitoAtsushi en-aut-sei=Saito en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=IguchiMasaharu en-aut-sei=Iguchi en-aut-mei=Masaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KasamakiYuji en-aut-sei=Kasamaki en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=NakahashiTakeshi en-aut-sei=Nakahashi en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=FukudaAkihiro en-aut-sei=Fukuda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=SaitoHitoshi en-aut-sei=Saito en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=KandaTsugiyasu en-aut-sei=Kanda en-aut-mei=Tsugiyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=OkuroMasashi en-aut-sei=Okuro en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= affil-num=1 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=2 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=3 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=4 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=5 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=6 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=7 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=8 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=9 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=10 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=11 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=12 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=13 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=14 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=15 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=16 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=17 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=18 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=19 en-affil=Kanazawa Medical University Himi Municipal Hospital kn-affil= affil-num=20 en-affil=Department of Geriatric Medicine, Kanazawa Medical University kn-affil= en-keyword=tofogliflozin kn-keyword=tofogliflozin en-keyword=SGLT2 inhibitor kn-keyword=SGLT2 inhibitor en-keyword=elderly patient kn-keyword=elderly patient en-keyword=HbA1c kn-keyword=HbA1c en-keyword=cardiac diastolic function kn-keyword=cardiac diastolic function END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=4 article-no= start-page=439 end-page=446 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Social Capital and Post-traumatic Stress Disorder among Heavy Rainfall and Flood Victims in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged?18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex. en-copyright= kn-copyright= en-aut-name=MiyajiChikara en-aut-sei=Miyaji en-aut-mei=Chikara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NoguchiMasayuki en-aut-sei=Noguchi en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkazakiTsubasa en-aut-sei=Okazaki en-aut-mei=Tsubasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoShunsuke en-aut-sei=Sato en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Okayama Prefectural Mental Health and Welfare Center kn-affil= affil-num=4 en-affil=Okayama Prefectural Mental Health and Welfare Center kn-affil= affil-num=5 en-affil=Okayama Prefectural Mental Health and Welfare Center kn-affil= affil-num=6 en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=social capital kn-keyword=social capital en-keyword=post-traumatic stress disorder kn-keyword=post-traumatic stress disorder en-keyword=disaster kn-keyword=disaster en-keyword=flooding kn-keyword=flooding END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=4 article-no= start-page=429 end-page=437 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Association between Preoperative Blood Pressure Elevations and Postoperative Adverse Outcomes after Non-cardiac Surgery: A Single-center Retrospective Observational Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Blood pressure (BP) often rises before surgery. This study investigated whether BP elevation immediately before surgery was associated with adverse outcomes. Medical records of 11,732 patients (average age: 61 years; male: 47.4%) who underwent non-cardiac elective inpatient surgery under general anesthesia at Kagawa University Hospital between January 2011 and June 2019 were reviewed. Differences between the first BP values measured on the day before surgery and the first BP values in the operating room were defined as ƒ¢ systolic BP (ƒ¢SBP) and ƒ¢ diastolic BP (ƒ¢DBP). The relationships between ƒ¢SBP/ƒ¢DBP and 30-day mortality, 30-day readmission, and over-the-standard length of hospital stay (OSLOS) were assessed. OSLOS was defined as a hospital stay longer than mean+2 standard deviations and was calculated using the Japanese Diagnosis Procedure Combination data. In univariate analysis, the differences in ƒ¢SBP and ƒ¢DBP between the OSLOS and standard LOS groups were both 2 mmHg. In multivariate logistic regression analysis, only ƒ¢DBP was associated with OSLOS. The adjusted odds ratio (95% confidence interval) for the largest quartile was 1.31 (1.02-1.69) (p<0.05). ƒ¢DBP was associated with OSLOS; however, there may be little need to worry about large ƒ¢SBPs and ƒ¢DBPs in clinical practice. en-copyright= kn-copyright= en-aut-name=YamadoriYusuke en-aut-sei=Yamadori en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiraoTomohiro en-aut-sei=Hirao en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Nlandu R. Ngatu en-aut-sei=Nlandu R. Ngatu en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KandaKanae en-aut-sei=Kanda en-aut-mei=Kanae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Syed Mahfuz Al Hasan en-aut-sei=Syed Mahfuz Al Hasan en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MurakamiAkitsu en-aut-sei=Murakami en-aut-mei=Akitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MashimaYukinori en-aut-sei=Mashima en-aut-mei=Yukinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShirakamiGotaro en-aut-sei=Shirakami en-aut-mei=Gotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Anesthesiology, Faculty of Medicine, Kagawa University kn-affil= affil-num=2 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=3 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=4 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=5 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=6 en-affil=Department of Anesthesiology, Faculty of Medicine, Kagawa University kn-affil= affil-num=7 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=8 en-affil=Department of Anesthesiology, Faculty of Medicine, Kagawa University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=3 article-no= start-page=339 end-page=342 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Rhabdomyolysis with Multiple Electrolyte Imbalances under Proton Pump Inhibitor Treatment after Total Thyroidectomy en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 90-year-old man presented with muscle weakness, difficulty concentrating, and dysphagia. About eighteen months prior to presentation, lansoprazole had been initiated to prevent stress ulcers; he also had a history of total thyroidectomy due to papillary thyroid cancer ten years prior. Laboratory findings were as follows: K 2.4 mEq/L, Ca 3.7 mg/dL, Mg 1.3 mg/dL, CK 5386 U/L, and intact PTH (iPTH) 14 pg/mL. Rhabdomyolysis with multiple electrolyte imbalances under proton pump inhibitor (PPI) treatment was diagnosed. We initiated intravenous hydration and electrolyte supplementation with discontinuation of PPI. After discontinuing PPI, the patientfs serum magnesium, potassium, and calcium levels normalised with oral vitamin D and calcium supplementation. PPIs can cause hypocalcaemia and hypokalaemia via hypomagnesemia; hypocalcaemia is also a common postoperative complication of thyroidectomy. Careful monitoring of electrolyte levels is required in patients with long-term PPI treatment, especially in post-thyroidectomy cases. en-copyright= kn-copyright= en-aut-name=YanoAkihiko en-aut-sei=Yano en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SadaKen-ei en-aut-sei=Sada en-aut-mei=Ken-ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SawadaTsutomu en-aut-sei=Sawada en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ItoHideki en-aut-sei=Ito en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YanoHiroko en-aut-sei=Yano en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IkedaTatsuya en-aut-sei=Ikeda en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of General Medicine, Kochi Health Sciences Center kn-affil= affil-num=2 en-affil=Department of General Medicine, Kochi Health Sciences Center kn-affil= affil-num=3 en-affil=Department of General Medicine, Kochi Health Sciences Center kn-affil= affil-num=4 en-affil=Department of General Medicine, Kochi Health Sciences Center kn-affil= affil-num=5 en-affil=Department of General Medicine, Kochi Health Sciences Center kn-affil= affil-num=6 en-affil=Department of General Medicine, Kochi Health Sciences Center kn-affil= en-keyword=hypocalcaemia kn-keyword=hypocalcaemia en-keyword=thyroidectomy kn-keyword=thyroidectomy en-keyword=proton pump inhibitors kn-keyword=proton pump inhibitors en-keyword=hypomagnesemia kn-keyword=hypomagnesemia en-keyword=rhabdomyolysis kn-keyword=rhabdomyolysis END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=3 article-no= start-page=333 end-page=338 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Successful Treatment of Atypical Femoral Fracture with Bowed Femur Using Contralateral Intramedullary Nail Combined with Early Daily Teriparatide en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a case of atypical femoral fracture achieving early fracture union with combination therapy comprising contralateral nail and immediate teriparatide injection. Fracture union of atypical fractures is often delayed due to bowing deformity and bone metabolic disorders. Combination treatment that takes both problems into consideration represents a useful treatment option for atypical femoral fracture. en-copyright= kn-copyright= en-aut-name=AkagawaManabu en-aut-sei=Akagawa en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyakoshiNaohisa en-aut-sei=Miyakoshi en-aut-mei=Naohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsuchieHiroyuki en-aut-sei=Tsuchie en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KasukawaYuji en-aut-sei=Kasukawa en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawaragiTakashi en-aut-sei=Kawaragi en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NagahataItsuki en-aut-sei=Nagahata en-aut-mei=Itsuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SuzukiMasazumi en-aut-sei=Suzuki en-aut-mei=Masazumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YoshikawaTakayuki en-aut-sei=Yoshikawa en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeToshiki en-aut-sei=Abe en-aut-mei=Toshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ShimadaYoichi en-aut-sei=Shimada en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Orthopedic Surgery, Omagari Kosei Medical Center kn-affil= affil-num=2 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=5 en-affil=Department of Orthopedic Surgery, Omagari Kosei Medical Center kn-affil= affil-num=6 en-affil=Department of Orthopedic Surgery, Omagari Kosei Medical Center kn-affil= affil-num=7 en-affil=Department of Orthopedic Surgery, Omagari Kosei Medical Center kn-affil= affil-num=8 en-affil=Department of Orthopedic Surgery, Omagari Kosei Medical Center kn-affil= affil-num=9 en-affil=Department of Orthopedic Surgery, Omagari Kosei Medical Center kn-affil= affil-num=10 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= en-keyword=atypical femoral fracture kn-keyword=atypical femoral fracture en-keyword=bowing deformity kn-keyword=bowing deformity en-keyword=intramedullary nail kn-keyword=intramedullary nail en-keyword=teriparatide kn-keyword=teriparatide en-keyword=cephalomedullary screw kn-keyword=cephalomedullary screw END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=3 article-no= start-page=291 end-page=295 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Factors Associated with Surgical Field Bacterial Detection during Total Hip Arthroplasty en-subtitle= kn-subtitle= en-abstract= kn-abstract=Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (} 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ? 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure. en-copyright= kn-copyright= en-aut-name=MiyakeYoshiaki en-aut-sei=Miyake en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MitaniShigeru en-aut-sei=Mitani en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NambaYoshifumi en-aut-sei=Namba en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UmeharaNorifumi en-aut-sei=Umehara en-aut-mei=Norifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawamotoToyohiro en-aut-sei=Kawamoto en-aut-mei=Toyohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FuruichiShuro en-aut-sei=Furuichi en-aut-mei=Shuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School kn-affil= affil-num=2 en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School kn-affil= affil-num=3 en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School kn-affil= en-keyword=total hip arthroplasty kn-keyword=total hip arthroplasty en-keyword=bacterial contamination kn-keyword=bacterial contamination en-keyword=periprosthetic joint infection kn-keyword=periprosthetic joint infection END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=2 article-no= start-page=137 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Changes in Plasma Clozapine Levels after Smoking Cessation in Japanese Inpatients with Schizophrenia: A Retrospective Cohort Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although reported for Caucasians, changes in plasma clozapine levels after smoking cessation in East Asians remain unclear. We here investigated plasma clozapine levels before and after smoking cessation in Japanese inpatients with schizophrenia. We conducted a retrospective chart review of 14 inpatients with schizophrenia who were being treated with clozapine between June 1, 2019, and July 31, 2019 and who were smokers as of July 1, 2019, the day on which a smoking ban was instituted in the tertiary public psychiatric hospital. The primary outcome was individual differences in plasma clozapine levels between before and after the smoking ban, which were compared using paired t-tests. The mean plasma clozapine level was significantly increased, by 213.4 ng/mL (95% CI 119.9-306.8; p<0.01) or 53.2%. Four of the 14 inpatients experienced clinically significant side effects, such as myoclonus, drooling, and amnesia, due to the development of high plasma clozapine levels. Our findings indicated that close monitoring of plasma clozapine levels before and after smoking cessation and prior dose adjustment of clozapine may be necessary, to prevent a significant risk of developing high plasma clozapine levels, even in Japanese patients. en-copyright= kn-copyright= en-aut-name=TsukaharaMasaru en-aut-sei=Tsukahara en-aut-mei=Masaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SoRyuhei en-aut-sei=So en-aut-mei=Ryuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YadaYuji en-aut-sei=Yada en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KodamaMasafumi en-aut-sei=Kodama en-aut-mei=Masafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KishiYoshiki en-aut-sei=Kishi en-aut-mei=Yoshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamadaNorihito en-aut-sei=Yamada en-aut-mei=Norihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center kn-affil= affil-num=2 en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center kn-affil= affil-num=3 en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center kn-affil= affil-num=4 en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center kn-affil= affil-num=5 en-affil=Department of Psychiatry, Okayama Psychiatric Medical Center kn-affil= affil-num=6 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Asian kn-keyword=Asian en-keyword=clozapine kn-keyword=clozapine en-keyword=schizophrenia kn-keyword=schizophrenia en-keyword=smoking kn-keyword=smoking END start-ver=1.4 cd-journal=joma no-vol=179 cd-vols= no-issue= article-no= start-page=137 end-page=156 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=High School Japanese Language Class Aimed at Developing the Power of Words That Can Be gCriticsh kn-title=u”á•]ŽÒv‚½‚蓾‚錾—t‚̗͂̈笂ð–ÚŽw‚µ‚½‚“™ŠwZ‘Œê‰ÈŽö‹Æ en-subtitle= kn-subtitle= en-abstract= kn-abstract=–{e‚ÍC—ߘa‚Q”N“x‰ªŽRŒ§—§‘ŽÐ‚“™ŠwZ‰Æ­‰È‚P”N¶‚ð‘ÎÛ‚Æ‚·‚éu‘Œê‘‡v‚ÌŽö‹Æ‚ÌŽÀ‘H•ñ‚Å‚ ‚éBeŽÒ‚ÍCŒ»Ý‚Ì‚“™ŠwZ‘Œê‰È‚̉ۑ莕ž‚ÉŒü‚¯‚½Žw“±ŽÒ‚ÌŽp¨‚Íu‹³Þ‚ւ̈ˑ¶“x‚Ì‚‚³‚©‚ç‚Ì’E‹pvu¶“k‚ð^‚̈Ӗ¡‚ÅuŽå‘Ì“I‚ÈŠw‚Ñv‚É—U‚¤ŠwKŠˆ“®‚ÌŽÀ‘Hv‚Å‚ ‚é‚Æ‚ÌŽ„Œ©‚ðŽ‚Á‚Ä‚¨‚èC–{e‚Å‚ÍŽ„Œ©‚É‚à‚Ƃ­Žp¨‚Ås‚Á‚½‚P”NŠÔ‚ÌŽö‹Æ‚ɂ‚¢‚ÄC‚»‚ÌŠT—v‚Æ‹³‰È‘ŠŽû‚Ì•¶Í‚ðuˆË‘¶‚©‚ç’Eov‚µ‚Ä‹³Þ•¶‚Æ‚µ‚Ä—p‚¢‚½’PŒ³‚Ì“à—e‚ð•ñ‚µ‚½BƒRƒƒi‰Ð‚̉e‹¿‚â•]‰¿‚Ì–Ê‚Å‚ÌŒ»ê‚ÌŽÀ‘ԂƂ̘¨—£CeŽÒ‚ÌŽö‹Æì‚è‚ÌuŠÃ‚³v“™‚É‚æ‚èC¬‰ÊˆÈã‚ɉۑè‚à‘½‚­Œ©o‚¹‚½‚à‚Ì‚ÌCŽ„Œ©‚Ì•ûŒü«‚ɊԈႢ‚ª‚È‚¢‚±‚Æ‚ªŽÀŠ´‚Å‚«‚½B en-copyright= kn-copyright= en-aut-name=MakinoShigeko en-aut-sei=Makino en-aut-mei=Shigeko kn-aut-name=ꠖ쎠Žq kn-aut-sei=ê –ì kn-aut-mei=Ž Žq aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Teaching and School Leadership Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È@‹³EŽÀ‘HuÀ en-keyword=u”á•]ŽÒv‚½‚蓾‚錾—t‚Ì—Í kn-keyword=u”á•]ŽÒv‚½‚蓾‚錾—t‚Ì—Í en-keyword=u‹³Þ‚ւ̈ˑ¶“x‚Ì‚‚³v‚©‚ç‚Ì’E‹p kn-keyword=u‹³Þ‚ւ̈ˑ¶“x‚Ì‚‚³v‚©‚ç‚Ì’E‹p END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1 article-no= start-page=63 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Chidamide and Decitabine in Combination with a HAG Priming Regimen for Acute Myeloid Leukemia with TP53 Mutation en-subtitle= kn-subtitle= en-abstract= kn-abstract=We analyzed the treatment effects of chidamide and decitabine in combination with a HAG (homoharringtonine, cytarabine, G-CSF) priming regimen (CDHAG) in acute myeloid leukemia (AML) patients with TP53 mutation. Seven TP53 mutated AML patients were treated with CDHAG. The treatment effects were assessed using hemogram detection and bone marrow aspirate. The possible side effects were evaluated based on both hematological and non-hematological toxicity. Four of the seven patients were classified as having achieved complete remission after CDHAG treatment; one patient was considered to have achieved partial remission, and the remaining two patients were considered in non-remission. The overall response rate (ORR) to CDHAG was 71.4%. Regarding the side effects, the hematological toxicity level of the seven patients ranged from level III to level IV, and infections that occurred at lung, blood, and skin were recorded. Nausea, vomiting, liver injury, and kidney injury were also detected. However, all side effects were attenuated by proper management. The CDHAG regimen clearly improved the ORR (71.4%) of TP53-mutated AML patients, with no severe side effects. en-copyright= kn-copyright= en-aut-name=ZhangBei en-aut-sei=Zhang en-aut-mei=Bei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=PeiZhixin en-aut-sei=Pei en-aut-mei=Zhixin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WangHongxia en-aut-sei=Wang en-aut-mei=Hongxia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WuHuimin en-aut-sei=Wu en-aut-mei=Huimin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WangJunjie en-aut-sei=Wang en-aut-mei=Junjie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=BaiJunjun en-aut-sei=Bai en-aut-mei=Junjun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SongQinglin en-aut-sei=Song en-aut-mei=Qinglin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Hematology, Jiaozuo Peoplefs Hospital kn-affil= affil-num=2 en-affil=Department of Hematology, Jiaozuo Peoplefs Hospital kn-affil= affil-num=3 en-affil=Department of Hematology, Jiaozuo Peoplefs Hospital kn-affil= affil-num=4 en-affil=Department of Hematology, Jiaozuo Peoplefs Hospital kn-affil= affil-num=5 en-affil=Department of Hematology, Jiaozuo Peoplefs Hospital kn-affil= affil-num=6 en-affil=Department of Hematology, Jiaozuo Peoplefs Hospital kn-affil= affil-num=7 en-affil=Department of Hematology, Jiaozuo Peoplefs Hospital kn-affil= en-keyword=acute myeloid leukemia kn-keyword=acute myeloid leukemia en-keyword=chidamide kn-keyword=chidamide en-keyword=decitabine kn-keyword=decitabine en-keyword=HAG kn-keyword=HAG en-keyword=TP53 mutation kn-keyword=TP53 mutation END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=1 article-no= start-page=137 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cancer-Associated Stromal Cells Promote the Contribution of MMP2-Positive Bone Marrow-Derived Cells to Oral Squamous Cell Carcinoma Invasion en-subtitle= kn-subtitle= en-abstract= kn-abstract=Simple Summary Based on its invasiveness, oral squamous cell carcinoma (OSCC) shows two different subtypes: less-invasive verrucous squamous carcinoma (VSCC) or highly invasive squamous cell carcinoma (SCC). The stromal component influences OSCC progression and invasion. On the other hand, bone marrow-derived cells (BMDCs) are recruited into tumors and involved in tumor development. We hypothesized that stromal factors might also affect the relation of BMDCs and tumor invasion. We established the OSCC models transplanted with stromal cells from VSCC and SCC, and we compared the potential stromal factors of VSCC and SCC for the involvement of BMDCs in tumor invasion. Our study showed that stromal factors IL6 and IL1B might promote the contribution of MMP-2 positive BMDCs to OSCC invasion. Tumor stromal components contribute to tumor development and invasion. However, the role of stromal cells in the contribution of bone marrow-derived cells (BMDCs) in oral squamous cell carcinoma (OSCC) invasion is unclear. In the present study, we created two different invasive OSCC patient-derived stroma xenografts (PDSXs) and analyzed and compared the effects of stromal cells on the relation of BMDCs and tumor invasion. We isolated stromal cells from two OSCC patients: less invasive verrucous OSCC (VSCC) and highly invasive conventional OSCC (SCC) and co-xenografted with the OSCC cell line (HSC-2) on green fluorescent protein (GFP)-positive bone marrow (BM) cells transplanted mice. We traced the GFP-positive BM cells by immunohistochemistry (IHC) and detected matrix metalloproteinase 2 (MMP2) expression on BM cells by double fluorescent IHC. The results indicated that the SCC-PDSX promotes MMP2-positive BMDCs recruitment to the invasive front line of the tumor. Furthermore, microarray analysis revealed that the expressions of interleukin 6; IL-6 mRNA and interleukin 1 beta; IL1B mRNA were higher in SCC stromal cells than in VSCC stromal cells. Thus, our study first reports that IL-6 and IL1B might be the potential stromal factors promoting the contribution of MMP2-positive BMDCs to OSCC invasion. en-copyright= kn-copyright= en-aut-name=OoMay Wathone en-aut-sei=Oo en-aut-mei=May Wathone kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawaiHotaka en-aut-sei=Kawai en-aut-mei=Hotaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakabatakeKiyofumi en-aut-sei=Takabatake en-aut-mei=Kiyofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShanQiusheng en-aut-sei=Shan en-aut-mei=Qiusheng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=EainHtoo Shwe en-aut-sei=Eain en-aut-mei=Htoo Shwe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SukegawaShintaro en-aut-sei=Sukegawa en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakanoKeisuke en-aut-sei=Nakano en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NagatsukaHitoshi en-aut-sei=Nagatsuka en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=oral squamous cell carcinoma invasion kn-keyword=oral squamous cell carcinoma invasion en-keyword=patient-derived stromal cell xenograft (PDSX) kn-keyword=patient-derived stromal cell xenograft (PDSX) en-keyword=bone marrow-derived cells (BMDCs) kn-keyword=bone marrow-derived cells (BMDCs) en-keyword=MMP2 kn-keyword=MMP2 en-keyword=stromal factor IL-6 kn-keyword=stromal factor IL-6 en-keyword=stromal factor IL1B kn-keyword=stromal factor IL1B END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=653 end-page=657 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Deep Angiomyxoma of the Thigh That Is Difficult to Diagnose: A Case Report and Literature Review en-subtitle= kn-subtitle= en-abstract= kn-abstract=We present an extremely rare case of deep angiomyxoma (DAM) in the thigh that was misdiagnosed as desmoid-type fibromatosis. A 40-year-old Japanese woman presented with a mass on the left thigh. The histological diagnosis by needle biopsy was desmoid-type fibromatosis; the tumor grew slowly and was resected 4 years later. The histological diagnosis from the resected tumor was DAM. As of 16 months post-surgery, the patient has not noticed any local recurrence. Although DAM in a lower extremity is extremely rare, clinicians must be aware of its possible occurrence in areas relatively close to the pelvis. en-copyright= kn-copyright= en-aut-name=TsuchieHiroyuki en-aut-sei=Tsuchie en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyakoshiNaohisa en-aut-sei=Miyakoshi en-aut-mei=Naohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NagasawaHiroyuki en-aut-sei=Nagasawa en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NanjoHiroshi en-aut-sei=Nanjo en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShimadaYoichi en-aut-sei=Shimada en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=2 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Pathology, Akita University Graduate School of Medicine kn-affil= affil-num=5 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= en-keyword=deep angiomyxoma kn-keyword=deep angiomyxoma en-keyword=thigh kn-keyword=thigh en-keyword=desmoid-type fibromatosis kn-keyword=desmoid-type fibromatosis END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=611 end-page=623 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Relation Between Identity Disclosure to Family Members and Mental Health in Japanese Transgender People en-subtitle= kn-subtitle= en-abstract= kn-abstract=Family members are critical mediators of the experiences of transgender people. We studied whether transgen-der subjects had disclosed their identity to their families and their familiesf reactions after the disclosure. We also evaluated the subjectsf mental state and its association with disclosure status. Transgender people were recruited for this anonymous questionnaire survey in the Okayama University Hospital gender clinic. Subjects disclosed their identity to family members at the following rates: 68.7% to the father, 89.1% to the mother, 59.1% to a brother, 77.8% to a sister, and 47.6% to grandparents. Fathers had the lowest rate (26.7%) of posi-tive reactions, while over 50% of fathers showed an ambiguous response. Approximately 20% of parents showed a negative response. The majority of parents agreed to hormonal treatment and sex-reassignment sur-gery and that the transgender child should live with the gender they wanted to express. However, the rate of subjects with mood and anxiety disorders according to the Kessler 6 scale was significantly higher in those who experienced negative or ambiguous reactions from family members compared to those who experienced posi-tive reactions. Educational and mental health professionals should support the disclosure process of transgen-der people as well as their family members. en-copyright= kn-copyright= en-aut-name=ZhouYu en-aut-sei=Zhou en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FurutaniMichiyo en-aut-sei=Furutani en-aut-mei=Michiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AthurupanaRukmali en-aut-sei=Athurupana en-aut-mei=Rukmali kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakatsukaMikiya en-aut-sei=Nakatsuka en-aut-mei=Mikiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=disclosure kn-keyword=disclosure en-keyword=family functioning kn-keyword=family functioning en-keyword=gender nonconformity kn-keyword=gender nonconformity en-keyword=mental health kn-keyword=mental health en-keyword=transgender kn-keyword=transgender END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=557 end-page=565 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Relationship between Pressure Ulcers in Elderly People and Physiological Indices of the Skin en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study examined the relationship between skin physiological indices and pressure ulcers in elderly people. The subjects were 55 bedridden elderly Japanese patients with a median age of 85 years. The following parame-ters were measured using non-invasive devices: skin surface temperature, moisture content in the stratum corneum, moisture content in the dermis, transepidermal water loss as an index of skin barrier function, skin erythema and skin elasticity. The sacral and 2 heel areas were observed as sites predisposed to pressure ulcers. Within one month after measuring the skin physiological indices, we confirmed pressure ulcers of National Pressure Ulcer Advisory Panel classification Stage II or worse based on medical records. Among the 55 patients, 4 (7.3%) prospectively developed a total of 5 pressure ulcers within 16 days. Only the skin erythema score was significantly higher with than without pressure ulcers (p < 0.001). We performed a binary logistic regression analysis and confirmed a significant relationship between pressure-ulcer development and the level of erythema (odds ratio = 1.026; 95% confidence interval: 1.011-1.042). Skin erythema increased before the development of pressure ulcers. Taken together, our results show that the high skin erythema score can be a predictive indicator of pressure ulcers. en-copyright= kn-copyright= en-aut-name=Takeshima KoharaHiroko en-aut-sei=Takeshima Kohara en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaMitsunori en-aut-sei=Ikeda en-aut-mei=Mitsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkawaMasami en-aut-sei=Okawa en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Nursing, University of Kochi kn-affil= affil-num=2 en-affil=Department of Nursing, University of Kochi kn-affil= affil-num=3 en-affil=Shiragikuen Hospital kn-affil= en-keyword=elderly people kn-keyword=elderly people en-keyword=erythema kn-keyword=erythema en-keyword=pressure ulcer kn-keyword=pressure ulcer en-keyword=skin kn-keyword=skin END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4 article-no= start-page=495 end-page=503 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Tablet Size and Head Posture on Drug Swallowing: A Preliminary Examination Using Endoscopy in Healthy Subjects en-subtitle= kn-subtitle= en-abstract= kn-abstract=Tablet size and head posture have been reported to affect swallowing of medications, but no previous studies have evaluated their effects in detail. Our aim was to investigate for the first time the effect of tablet size and head posture on drug swallowing by endoscopic evaluation in healthy subjects. Round tablets (7 , 10 , 12, and 14 mm in diameter) were swallowed by 15 healthy adults with an endoscope inserted in the neutral, head flex-ion, and head extension positions. Evaluation of swallowing difficulty using a numeric rating scale (NRS), presence or absence of pharyngeal residue and its location, and tablet oral transit time (TOTT) were recorded. In the neutral position, the NRS score was higher with the 14 mm tablets than with the 7 mm tablets. The TOTT with the 7 mm tablets was significantly shorter in the head extension than in the neutral position. Swallowing difficulty increased when the tablet diameter was more than 7 mm. Residues were found in the epi-glottis, pyriform sinus, and tongue base. These findings suggest that head extension shortens the TOTT and assists oral-pharyngeal transport. en-copyright= kn-copyright= en-aut-name=SugiyamaShuntaro en-aut-sei=Sugiyama en-aut-mei=Shuntaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IidaTakatoshi en-aut-sei=Iida en-aut-mei=Takatoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MorimotoYoshinari en-aut-sei=Morimoto en-aut-mei=Yoshinari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamazakiYuki en-aut-sei=Yamazaki en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MikuzukiLou en-aut-sei=Mikuzuki en-aut-mei=Lou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HayashiMegumi en-aut-sei=Hayashi en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Division of Medically Compromised Geriatric Dentistry, Department of Critical Care Medicine and Dentistry, Kanagawa Dental University Hospital Graduate School of Dentistry kn-affil= affil-num=2 en-affil=Division of Medically Compromised Geriatric Dentistry, Department of Critical Care Medicine and Dentistry, Kanagawa Dental University Hospital Graduate School of Dentistry kn-affil= affil-num=3 en-affil=Division of Medically Compromised Geriatric Dentistry, Department of Critical Care Medicine and Dentistry, Kanagawa Dental University Hospital Graduate School of Dentistry kn-affil= affil-num=4 en-affil=Division of Medically Compromised Geriatric Dentistry, Department of Pharmacy, Kanagawa Dental University Hospital kn-affil= affil-num=5 en-affil=Division of Medically Compromised Geriatric Dentistry, Department of Critical Care Medicine and Dentistry, Kanagawa Dental University Hospital Graduate School of Dentistry kn-affil= affil-num=6 en-affil=Division of Medically Compromised Geriatric Dentistry, Department of Critical Care Medicine and Dentistry, Kanagawa Dental University Hospital Graduate School of Dentistry kn-affil= en-keyword=tablet size kn-keyword=tablet size en-keyword=head posture kn-keyword=head posture en-keyword=swallowing kn-keyword=swallowing en-keyword=endoscopy kn-keyword=endoscopy en-keyword=pharyngeal residue kn-keyword=pharyngeal residue END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4 article-no= start-page=439 end-page=445 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical Course of 60 Cesarean Scar Pregnancies en-subtitle= kn-subtitle= en-abstract= kn-abstract=Early diagnosis and therapy are important in a cesarean scar pregnancy (CSP), which can cause uterine rupture with resultant massive bleeding. However, there are some reports of CSPs continued to term. The optimal management of CSPs remains unclear; therefore, we investigated the clinical courses of CSPs diagnosed and treated at perinatal institutions in the Chugoku and Shikoku regions of Japan. We enrolled 60 women diag-nosed with CSP at 21 institutions from January 2006 to December 2015. Of the 60 women diagnosed with CSP, 57 were treated. Pregnancy was terminated in 48 women and continued in 9. Thirteen women underwent transabdominal hysterectomy; they experienced no postoperative complications or allogeneic blood transfu-sion. Nine women received therapies such as dilation and curettage, and 26 received non-surgical therapies such as methotrexate and topical administration of potassium chloride. Among 9 women who chose to con-tinue with their CSP, 7 successfully delivered newborns, 2 had uterine ruptures in the second trimester, and all women required transabdominal hysterectomy. Diagnosis and therapy in the first trimester of pregnancy are important in the management strategy of a CSP. When continuing a CSP, the risk of uterine rupture and trans-abdominal hysterectomy must be considered. en-copyright= kn-copyright= en-aut-name=MitsuiTakashi en-aut-sei=Mitsui en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MishimaSakurako en-aut-sei=Mishima en-aut-mei=Sakurako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniKazumasa en-aut-sei=Tani en-aut-mei=Kazumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MakiJota en-aut-sei=Maki en-aut-mei=Jota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=EtoEriko en-aut-sei=Eto en-aut-mei=Eriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HayataKei en-aut-sei=Hayata en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MasuyamaHisashi en-aut-sei=Masuyama en-aut-mei=Hisashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=cesarean scar pregnancy kn-keyword=cesarean scar pregnancy en-keyword=uterine rupture kn-keyword=uterine rupture en-keyword=hysterectomy kn-keyword=hysterectomy en-keyword=methotrexate kn-keyword=methotrexate en-keyword=potassium chloride kn-keyword=potassium chloride END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4 article-no= start-page=403 end-page=413 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Surgical Treatment of Epiretinal Membrane en-subtitle= kn-subtitle= en-abstract= kn-abstract=Epiretinal membrane (ERM) is a common retinal disease characterized by cellular proliferation and metaplasia that lead to the formation of a pathological fibrocellular membrane immediately superjacent to the inner retinal surface. The vast majority of ERMs are considered idiopathic. However, ERM formation can result from various primary intraocular diseases, including retinal breaks and detachment, retinal vascular diseases, and vitreoretinal inflammatory conditions. Although ERMs are generally asymptomatic or cause mild metamorphopsia and/or a modest decrease in visual acuity, some can cause severe macular distortion and macular edema, resulting in significantly impaired function. Surgical removal of ERM is the only treatment, and improvements in vitrectomy systems have enabled less invasive treatment. However, there are currently no standardized criteria for ERM surgery, and the indications for surgery are determined from the patientfs subjective symptoms. Another problem with ERM surgery is that not all patients show satisfactory postoperative recovery of visual function. Thus, further research is needed to determine the criteria for ERM surgery and methods to improve the postoperative prognosis. en-copyright= kn-copyright= en-aut-name=MatobaRyo en-aut-sei=Matoba en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorizaneYuki en-aut-sei=Morizane en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=epiretinal membrane kn-keyword=epiretinal membrane en-keyword=vitrectomy kn-keyword=vitrectomy en-keyword=optical coherence tomography kn-keyword=optical coherence tomography en-keyword=internal limiting membrane kn-keyword=internal limiting membrane en-keyword=lamellar macular hole kn-keyword=lamellar macular hole END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=219 end-page=224 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Successful Treatment of Acute Promyelocytic Leukemia Complicated with Endometrial Cancer by Arsenic Trioxide en-subtitle= kn-subtitle= en-abstract= kn-abstract=Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumorfs treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer. en-copyright= kn-copyright= en-aut-name=SugiuraHiroyuki en-aut-sei=Sugiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuokaHirofumi en-aut-sei=Matsuoka en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraKeiichiro en-aut-sei=Nakamura en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiiKeiko en-aut-sei=Fujii en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujiiNobuharu en-aut-sei=Fujii en-aut-mei=Nobuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsuokaKen-ichi en-aut-sei=Matsuoka en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=acute promyelocytic leukemia kn-keyword=acute promyelocytic leukemia en-keyword=endometrial cancer kn-keyword=endometrial cancer en-keyword=arsenic trioxide kn-keyword=arsenic trioxide en-keyword=synchronous multiple primary malignant tumor kn-keyword=synchronous multiple primary malignant tumor en-keyword=chemotherapy kn-keyword=chemotherapy END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=205 end-page=212 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Camouflage Treatment for Skeletal Maxillary Protrusion and Lateral Deviation with Classic-Type Ehlers-Danlos Syndrome en-subtitle= kn-subtitle= en-abstract= kn-abstract=We herein report the case of a 19-year-old female with a transverse discrepancy, skeletal Class II malocclusion, severe crowding with concerns of classic-type Ehlers-Danlos syndrome (EDS), aesthetics problems and functional problems. The main characteristics of classic EDS are loose-jointedness and fragile, easily bruised skin that heals with peculiar gcigarette-paperh scars. The anteroposterior and transverse skeletal discrepancies can generally be resolved by maxilla repositioning and mandibular advancement surgery following pre-surgical orthodontic treatment. However, this patient was treated with orthodontic camouflage but not orthognathic surgery because of the risks of skin bruising, poor healing and a temporomandibular disorder. A satisfactory dental appearance and occlusion were achieved after camouflage treatment with orthodontic anchor screws and the use of Class II elastics, including the preservation of the stomatognathic functions. Acceptable occlusion and dentition were maintained after a two-year retention period. This treatment strategy of orthodontic camouflage using temporary anchorage, such as anchor screws and Class II elastics, may be a viable treatment option for skeletal malocclusion patients with EDS. en-copyright= kn-copyright= en-aut-name=HoshijimaMitsuhiro en-aut-sei=Hoshijima en-aut-mei=Mitsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawanabeNoriaki en-aut-sei=Kawanabe en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IidaSeiji en-aut-sei=Iida en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamashiroTakashi en-aut-sei=Yamashiro en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KamiokaHiroshi en-aut-sei=Kamioka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University kn-affil= affil-num=5 en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=asymmetry kn-keyword=asymmetry en-keyword=Class II kn-keyword=Class II en-keyword=camouflage kn-keyword=camouflage en-keyword=orthodontic anchor screw kn-keyword=orthodontic anchor screw en-keyword=Ehlers-Danlos syndrome kn-keyword=Ehlers-Danlos syndrome END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=133 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Efficacy and Safety of Ramucirumab/nab-paclitaxel for Previously Treated Advanced Gastric Cancer in Community Hospitals en-subtitle= kn-subtitle= en-abstract= kn-abstract=As the nanoparticle albumin-bound paclitaxel (nab-PTX) is free of ethanol and premedication, the duration of administration is shorter and patients can drive themselves to and from the hospital. In the 2018 Japanese gastric cancer treatment guidelines, ramucirumab (RAM) plus weekly nab-PTX is conditionally recommended for previously treated patients with advanced gastric cancer. Here, we retrospectively analysed the efficacy and safety of RAM+nab-PTX for such patients in community hospitals. From January 2018 to December 2019, 43 patients with metastatic and recurrent gastric cancer received RAM+nab-PTX treatment. Six patients (13.9%) were older than 80 years and 9 patients (20.9%) showed ECOG-PS 2. Progression-free survival (PFS), overall survival (OS), overall response rate (ORR), disease control rate (DCR), and adverse events (AEs) were reviewed retrospectively. Median PFS was 114 days (95% confidence interval [CI]: 84-190) and median OS was 297 days (95% CI: 180-398). ORR and DCR were 32.4% and 72.2%, respectively. The incidence rates of ?grade 3 neutropenia and febrile neutropenia were 53.5% and 2.3%, respectively. No treatment-related deaths occurred. RAM plus nab-PTX combination therapy demonstrated manageable toxicity even patients who were elderly or had an ECOG-PS 2. This treatment is useful in community hospital settings. en-copyright= kn-copyright= en-aut-name=HashidaShinsuke en-aut-sei=Hashida en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaNorimitsu en-aut-sei=Tanaka en-aut-mei=Norimitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiYuta en-aut-sei=Takahashi en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OnodaYuji en-aut-sei=Onoda en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ColvinHugh Shunsuke en-aut-sei=Colvin en-aut-mei=Hugh Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OhashiRyuichiro en-aut-sei=Ohashi en-aut-mei=Ryuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoKunio en-aut-sei=Okamoto en-aut-mei=Kunio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Kagawa Prefectural Central Hospital kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Kagawa Prefectural Central Hospital kn-affil= affil-num=3 en-affil=Department of Gastroenterological Surgery, Kagawa Prefectural Central Hospital kn-affil= affil-num=4 en-affil=Department of Gastroenterological Surgery, Kagawa Prefectural Central Hospital kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Kagawa Prefectural Central Hospital kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Kagawa Prefectural Central Hospital kn-affil= affil-num=7 en-affil=Department of Medical Oncology, Kagawa Prefectural Central Hospital kn-affil= en-keyword=gastric cancer kn-keyword=gastric cancer en-keyword=ramucirumab kn-keyword=ramucirumab en-keyword=nab-paclitaxel kn-keyword=nab-paclitaxel END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=1 article-no= start-page=130 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=2020727 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Long-term ureteroscopic management of upper tract urothelial carcinoma: 28-year single-centre experience en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background
Long-term survival outcomes of patients who undergo endoscopic management of non-invasive upper tract urothelial carcinoma remain uncertain. The longest mean follow-up period in previous studies was 6.1 years. This study reports the long-term outcomes of patients with upper tract urothelial carcinoma who underwent ureteroscopic ablation at a single institution over a 28-year period.
Methods
We identified all patients who underwent ureteroscopic management of upper tract urothelial carcinoma as their primary treatment at our institution between January 1991 and April 2011. Survival outcomes, including overall survival, cancer-specific survival, upper-tract recurrence-free survival and renal unit survival, were estimated using Kaplan?Meier methodology.
Results
A total of 15 patients underwent endoscopic management, with a mean age at diagnosis of 66 years. All patients underwent ureteroscopy, and biopsy-confirmed pathology was obtained. Median (range; mean) follow-up was 11.7 (2.3?20.9, 11.9) years. Upper tract recurrence occurred in 87% (n = 13) of patients. Twenty percent (n = 3) of patients proceeded to nephroureterectomy. The estimated cancer-specific survival rate was 93% at 5, 10, 15 and 20 years. Estimated overall survival rates were 86, 80, 54 and 20% at 5, 10, 15 and 20 years. Only one patient experienced cancer-specific mortality. The estimated mean and median overall survival times were 14.5 and 16.6 years, respectively. The estimated mean cancer-specific survival time was not reached.
Conclusions
Although upper tract recurrence is common, endoscopic management of non-invasive upper tract urothelial carcinoma provides a 90% cancer-specific survival rate at 20 years in selected patients. en-copyright= kn-copyright= en-aut-name=MaruyamaYuki en-aut-sei=Maruyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WadaKoichiro en-aut-sei=Wada en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MitsuiYosuke en-aut-sei=Mitsui en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WatanabeMasami en-aut-sei=Watanabe en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=WatanabeToyohiko en-aut-sei=Watanabe en-aut-mei=Toyohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MongaManoj en-aut-sei=Monga en-aut-mei=Manoj kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KumonHiromi en-aut-sei=Kumon en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=2 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=3 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=4 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=5 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=6 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=7 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=10 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=11 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=12 en-affil=Department of Urology, The Cleveland Clinic kn-affil= affil-num=13 en-affil=Department of Urology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Science kn-affil= affil-num=14 en-affil=Innovation Center Okayama for Nanobio-Targeted Therapy, Okayama University kn-affil= en-keyword=urothelial carcinoma kn-keyword=urothelial carcinoma en-keyword=urinary tract cancer kn-keyword=urinary tract cancer en-keyword=ureteroscopy kn-keyword=ureteroscopy en-keyword=long-term survival kn-keyword=long-term survival en-keyword=renal pelvis kn-keyword=renal pelvis en-keyword=ureter kn-keyword=ureter END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1 article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202102 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical Characteristics of Low Androgen Status in Males with Type 2 Diabetes Mellitus en-subtitle= kn-subtitle= en-abstract= kn-abstract=To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 } 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ? 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ? BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = ?0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males. en-copyright= kn-copyright= en-aut-name=HamaharaJun en-aut-sei=Hamahara en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HondaHiroyuki en-aut-sei=Honda en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamamotoKoichiro en-aut-sei=Yamamoto en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TokumasuKazuki en-aut-sei=Tokumasu en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HanayamaYoshihisa en-aut-sei=Hanayama en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UedaKeigo en-aut-sei=Ueda en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KishidaMasayuki en-aut-sei=Kishida en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=androgen kn-keyword=androgen en-keyword=diabetes mellitus kn-keyword=diabetes mellitus en-keyword=late-onset hypogonadism kn-keyword=late-onset hypogonadism en-keyword=testosterone kn-keyword=testosterone en-keyword=thyroid function kn-keyword=thyroid function END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=6 article-no= start-page=557 end-page=562 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively. en-copyright= kn-copyright= en-aut-name=IshiguroMikako en-aut-sei=Ishiguro en-aut-mei=Mikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakenakaRyuta en-aut-sei=Takenaka en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OguraKenichiro en-aut-sei=Ogura en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HiratsukaAkira en-aut-sei=Hiratsuka en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakedaHiromasa en-aut-sei=Takeda en-aut-mei=Hiromasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawaiDaisuke en-aut-sei=Kawai en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujikiShigeatsu en-aut-sei=Fujiki en-aut-mei=Shigeatsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Internal Medicine, Tsuyama Chuo Hospital kn-affil= affil-num=2 en-affil=Department of Internal Medicine, Tsuyama Chuo Hospital kn-affil= affil-num=3 en-affil=Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences kn-affil= affil-num=4 en-affil=Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences kn-affil= affil-num=5 en-affil=Department of Internal Medicine, Tsuyama Chuo Hospital kn-affil= affil-num=6 en-affil=Department of Internal Medicine, Tsuyama Chuo Hospital kn-affil= affil-num=7 en-affil=Department of Internal Medicine, Tsuyama Chuo Hospital kn-affil= affil-num=8 en-affil=Department of Internal Medicine, Tsuyama Chuo Hospital kn-affil= affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=5-fluorouracil kn-keyword=5-fluorouracil en-keyword=dihydropyrimidine dehydrogenase deficiency kn-keyword=dihydropyrimidine dehydrogenase deficiency en-keyword=DPYD variant kn-keyword=DPYD variant en-keyword=gastric cancer kn-keyword=gastric cancer END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=6 article-no= start-page=461 end-page=466 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Reality of Gastric Cancer in Young Patients: The Importance and Difficulty of the Early Diagnosis, Prevention and Treatment en-subtitle= kn-subtitle= en-abstract= kn-abstract=Gastric cancer usually arises in middle-aged to older patients, and is rarely found in younger patients. The clin-ical characteristics, etiology, prognosis, preventive methods and treatment of gastric cancer in young patients have not been fully investigated because of its low prevalence. In this review, we discuss the current under-standing and clinical problems associated with gastric cancer in young patients. Helicobacter pylori (H. pylori), which is a major cause of gastric cancer, especially in older populations, is closely associated with gastric cancer in young patients as well as in older patients. Gastric cancer in young patients tends to be diagnosed at an advanced stage with alarm symptoms. However, young patients with advanced gastric cancer tend to have a favorable general condition and organ function, so they can tolerate intensive systematic chemotherapy. Unfortunately, the prognosis of gastric cancer in young patients with an advanced stage is not favorable. We should not take this rare disease lightly, given its poor prognosis if patients are diagnosed at an unresectable stage. The evaluation of the H. pylori infection status and performance of H. pylori eradication therapy to prevent gastric cancer in young patients as well as the development of more intensive chemotherapy regimens for unre-sectable gastric cancer in young patients are warranted. en-copyright= kn-copyright= en-aut-name=KonoYoshiyasu en-aut-sei=Kono en-aut-mei=Yoshiyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KanzakiHiromitsu en-aut-sei=Kanzaki en-aut-mei=Hiromitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=gastric cancer kn-keyword=gastric cancer en-keyword=young patients kn-keyword=young patients en-keyword=Helicobacter pylori kn-keyword=Helicobacter pylori END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=19 article-no= start-page=137 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=”»’f•¶EŒ»Û•`ŽÊ•¶‚ƃvƒƒgƒ^ƒCƒv˜_ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‹{è˜al kn-aut-sei=‹{è kn-aut-mei=˜al aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‘—§V‹•lH‹Æ‚“™ê–åŠwZ END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4 article-no= start-page=359 end-page=364 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Hospital Evacuation Assistance from Public and Private Resources: Lessons Learned from the 2018 Western Japan Floods en-subtitle= kn-subtitle= en-abstract= kn-abstract=During major flooding in June/July 2018, the Mabi Memorial Hospital in Kurashiki, Okayama, Japan was flooded and patients were stranded in the hospital. Peace Winds Japan, a non-governmental organization, collaborated with the Japanese Disaster Medical Assistance Team and Self-Defense Force Public to transport 8 critical patients from the hospital by helicopter. Ultimately, 54 patients and hospital staff members were safely evacuated. The evacuation was accomplished without any casualties, despite the severe conditions. Public and private organizations can work together and continue to seek ways to collaborate and cooperate in disaster settings. en-copyright= kn-copyright= en-aut-name=InabaMototaka en-aut-sei=Inaba en-aut-mei=Mototaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MuramatsuTomoyoshi en-aut-sei=Muramatsu en-aut-mei=Tomoyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaTaihei en-aut-sei=Yamada en-aut-mei=Taihei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakataTaizo en-aut-sei=Sakata en-aut-mei=Taizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Mabi Memorial Hospital kn-affil= affil-num=4 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Peace Winds Japan kn-affil= affil-num=6 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=natural disaster kn-keyword=natural disaster en-keyword=transportation kn-keyword=transportation en-keyword=rain kn-keyword=rain en-keyword=relief work kn-keyword=relief work en-keyword=public-private sector partnerships kn-keyword=public-private sector partnerships END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4 article-no= start-page=335 end-page=343 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Recurrence of Solitary Fibrous Tumor/Hemangiopericytoma Could Be Predicted by Ki-67 Regardless of Its Origin en-subtitle= kn-subtitle= en-abstract= kn-abstract=Since the discovery of the NAB2-STAT6 gene fusion in 2013, solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) have been considered the same disease. STAT6 nuclear stain is approved as a highly sensitive and specific marker to diagnose SFT/HPC from other tumors with similar histology. As the next step, detection of fusion variants that may predict clinical malignancy of SFT/HPC has been attempted. However, no fusion variants with a clear relation to malignancy have been identified. In this study, the clinical and histological backgrounds of 23 Japanese patients diagnosed with SFT/HPC from 2000 to 2019 at Kochi University Hospital were examined to identify factors potentially related to recurrence. A significant relationship to recurrence was detected for mitosis ? 1/10 HPF (400~), necrosis, and Ki-67>5%. These findings indicate that a deliberate investigation of histological features such as mitosis and necrosis is crucial for the clinical observation of SFT/ HPC patients. In addition, Ki-67 was revealed to be a useful parameter to predict recurrence in SFT/HPC patients. en-copyright= kn-copyright= en-aut-name=YamamotoYumiko en-aut-sei=Yamamoto en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HayashiYoshihiro en-aut-sei=Hayashi en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MurakamiIchiro en-aut-sei=Murakami en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Diagnostic Pathology, Kochi University kn-affil= affil-num=2 en-affil=Department of Equipment of Support Planning Office, Kochi University kn-affil= affil-num=3 en-affil=Department of Diagnostic Pathology, Kochi University kn-affil= en-keyword=solitary fibrous tumor kn-keyword=solitary fibrous tumor en-keyword=hemangiopericytoma kn-keyword=hemangiopericytoma en-keyword=Ki-67 kn-keyword=Ki-67 en-keyword=NAB2-STAT6 kn-keyword=NAB2-STAT6 en-keyword=WHO classification kn-keyword=WHO classification en-keyword=WHO grading criteria kn-keyword=WHO grading criteria en-keyword=Marseille Grading System kn-keyword=Marseille Grading System END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4 article-no= start-page=301 end-page=306 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Immobility-reducing Effects of Ketamine during the Forced Swim Test on 5-HT1A Receptor Activity in the Medial Prefrontal Cortex in an Intractable Depression Model en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the ratsf immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex. en-copyright= kn-copyright= en-aut-name=TakahashiKei en-aut-sei=Takahashi en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UshioSoichiro en-aut-sei=Ushio en-aut-mei=Soichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=ketamine kn-keyword=ketamine en-keyword=adrenocorticotropic hormone kn-keyword=adrenocorticotropic hormone en-keyword=forced swim test kn-keyword=forced swim test en-keyword=medial prefrontal cortex kn-keyword=medial prefrontal cortex en-keyword=5-HT1A receptor kn-keyword=5-HT1A receptor END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=2 article-no= start-page=137 end-page=149 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191023 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A proposal of calligraphy learning assistant system with letter portion practice function using projection mapping en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose
For several decades, calligraphy has been popular among people in Japan, China, and even in the world. Traditionally, a teacher teaches how to write letters on a paper with a brush, and a student will imitate them by referring to the model letters. However, if a teacher is not available, this method will not be applicable either. This study aims to propose a calligraphy learning assistant system (CLAS) using projection mapping, which allows a student to learn calligraphy by him/herself.
Design/methodology/approach
By following the letter writing video of a teacher that is directly projected on the paper, a student is able to learn the stroke order and writing speed in addition to the letter shape. Moreover, the letter portion practice function is incorporated in CLAS to allow a learner to repeat practicing hard portions of each letter.
Findings
For evaluations, the authors implemented CLAS using Raspberry Pi and open-source software and asked students to use it. The results confirmed that CLAS is effective in improving calligraphy skills of novice students.
Originality/value
With CLAS, a student can practice calligraphy using a conventional brush, ink and paper at a desk while looking at the model letter writing of a teacher projected on the paper using projection mapping. en-copyright= kn-copyright= en-aut-name=HudaSamsul en-aut-sei=Huda en-aut-mei=Samsul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FunabikiNobuo en-aut-sei=Funabiki en-aut-mei=Nobuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KuribayashiMinoru en-aut-sei=Kuribayashi en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KaoWen-Chung en-aut-sei=Kao en-aut-mei=Wen-Chung kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Electrical and Communication Engineering, Okayama University kn-affil= affil-num=2 en-affil=Department of Electrical and Communication Engineering, Okayama University kn-affil= affil-num=3 en-affil=Department of Electrical and Communication Engineering, Okayama University kn-affil= affil-num=4 en-affil=Department of Electrical Engineering, National Taiwan Normal University kn-affil= en-keyword=Raspberry Pi kn-keyword=Raspberry Pi en-keyword=Calligraphy kn-keyword=Calligraphy en-keyword=Learning assistant system kn-keyword=Learning assistant system en-keyword=Projection mapping kn-keyword=Projection mapping END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=3 article-no= start-page=185 end-page=190 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202006 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Stem Cell Therapy in Heart Disease: Limitations and Future Possibilities en-subtitle= kn-subtitle= en-abstract= kn-abstract=Heart diseases are one of the major causes of morbidity and mortality worldwide. Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. Stem cell therapy has emerged as one option for the treatment of a variety of heart diseases. Although a large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach, the results obtained from these clinical studies are inconsistent, and stem cell-based improvements of heart performance and cardiac remodeling were found to be quite limited. Since the precise mechanisms underlying the therapeutic actions of stem cells are still under debate, researchers have developed a variety of strategies to improve and boost the potency of stem cells in repair. In this review, we summarize both the current therapeutic strategies using stem cells and future directions for enhancing stem cell potency. en-copyright= kn-copyright= en-aut-name=SanoToshikazu en-aut-sei=Sano en-aut-mei=Toshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshigamiShuta en-aut-sei=Ishigami en-aut-mei=Shuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ItoTatsuo en-aut-sei=Ito en-aut-mei=Tatsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SanoShunji en-aut-sei=Sano en-aut-mei=Shunji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco kn-affil= affil-num=2 en-affil=Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco kn-affil= affil-num=3 en-affil=Department of Hygiene, Kawasaki Medical University kn-affil= affil-num=4 en-affil=Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco kn-affil= en-keyword=heart disease kn-keyword=heart disease en-keyword=stem cell kn-keyword=stem cell en-keyword=myocardial regeneration kn-keyword=myocardial regeneration END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year= dt-pub= dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Alopecurus myosuroides Huds. kn-title=ƒmƒXƒYƒƒmƒeƒbƒ|ƒE en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-keyword=ƒCƒl‰È (Poaceae) kn-keyword=ƒCƒl‰È (Poaceae) END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=2 article-no= start-page=137 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mucinous Carcinoma of the Breast: Clinicopathological Features and Long-term Prognosis in Comparison with Invasive Ductal Cancer; A Single Hospitalfs 30+-Year Experience en-subtitle= kn-subtitle= en-abstract= kn-abstract= Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer. en-copyright= kn-copyright= en-aut-name=IsozakiHiroshi en-aut-sei=Isozaki en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamotoYasuhisa en-aut-sei=Yamamoto en-aut-mei=Yasuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakaiKunihiko en-aut-sei=Sakai en-aut-mei=Kunihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShoTatuo en-aut-sei=Sho en-aut-mei=Tatuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IshiharaKiyohiro en-aut-sei=Ishihara en-aut-mei=Kiyohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MurakamiShigeki en-aut-sei=Murakami en-aut-mei=Shigeki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsumotoSasau en-aut-sei=Matsumoto en-aut-mei=Sasau kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakamaTakehiro en-aut-sei=Takama en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Surgery, Oomoto Hospital kn-affil= affil-num=2 en-affil=Department of Surgery, Oomoto Hospital kn-affil= affil-num=3 en-affil=Department of Surgery, Oomoto Hospital kn-affil= affil-num=4 en-affil=Department of Surgery, Oomoto Hospital kn-affil= affil-num=5 en-affil=Department of Surgery, Oomoto Hospital kn-affil= affil-num=6 en-affil=Department of Surgery, Oomoto Hospital kn-affil= affil-num=7 en-affil=Department of Surgery, Oomoto Hospital kn-affil= affil-num=8 en-affil=Department of Surgery, Oomoto Hospital kn-affil= en-keyword=breast cancer kn-keyword=breast cancer en-keyword=mucinous carcinoma kn-keyword=mucinous carcinoma en-keyword=clinicopathological features kn-keyword=clinicopathological features en-keyword=long-term prognosis kn-keyword=long-term prognosis END start-ver=1.4 cd-journal=joma no-vol=131 cd-vols= no-issue=3 article-no= start-page=135 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2018 Incentive Award of the Okayama Medical Association in Neuroscience (2018 Niimi Prize) kn-title=•½¬30”N“x‰ªŽRˆãŠw‰ïÜ ”]_ŒoŒ¤‹†§—ãÜiVŒ©Üj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=EdamatsuMidori en-aut-sei=Edamatsu en-aut-mei=Midori kn-aut-name=Ž}¼—Î kn-aut-sei=Ž}¼ kn-aut-mei=—Î aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@•ªŽqˆã‰»Šw END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue= article-no= start-page=123 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research on Facial Expression and Vocalization in Singing kn-title=‰Ì¥Žž‚É‚¨‚¯‚é•\î‚Æ”­º‚ÉŠÖ‚·‚錤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract= ‰¹ŠyŽö‹Æ“™‚ÅŽ™“¶E¶“k‚ª‰Ì¥‚·‚鎞‚Ì•\î‚ÍC”­º‚ɂǂ̂悤‚ɉe‹¿‚·‚é‚Ì‚¾‚낤‚©B‚±‚Ì‹^–â‚𖾂炩‚É‚·‚邽‚ß‚ÉC•MŽÒ“™‚ÍC¬Šw¶‚©‚ç‘åŠw¶‚ð‘ÎÛ‚ÉC–³•\îE“{‚èE”ß‚µ‚ÝEΊç‚Ì•\î‚ðŽæ‚è“ü‚ê‚ĉ̂¤‰Ì¥ŽÀŒ±‚¨‚æ‚щ̥ŽÒ‚ւ̃Aƒ“ƒP[ƒg’²¸‚ðŽÀŽ{‚µC•\î‚̕ω»‚ª‚à‚½‚ç‚·Œø‰Ê‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½B‚»‚ÌŒ‹‰ÊC‚æ‚è‚æ‚¢‰Ì¥Žž‚Ì•\î‚ÌŒø‰Ê‚Å‚ÍCΊç‚Ì•\‰Ì‚¢‚â‚·‚­C”­º–Ê‚Å—Ç‚¢Œø‰Ê‚ð‚à‚½‚炵‚Ä‚¢‚邱‚Æ‚ª–¾‚ç‚©‚Æ‚È‚Á‚½B‚Ü‚½CΊç‚Ì•\î‚Ì’†‚Å‚àm‚½‚Än‚ÌΊ炪‹¿‚«‚₉¹‚Ì”­º‚É—ÇD‚Å‚ ‚邱‚ÆC[‚悱]‚ÌΊç‚ÍC‰Ì‚¢‚â‚·‚¢‚ª—Í‚Ý‚â‚·‚¢‚±‚ÆCΊç‚Ì•\î‚Å‚ÍCŒû‚ÌŠJ‚¯•û‚ðˆÓŽ¯‚µ‚Ä‚¢‚邱‚Æ‚ªŽ¦‚³‚ꂽBƒAƒ“ƒP[ƒg’²¸‚©‚ç‚ÍC”N‘オ‘å‚«‚­‚È‚é‚Ù‚ÇC•\î‚É‚æ‚Á‚ĺ‚ª•Ï‰»‚·‚é‚Æ”FŽ¯‚µ‚Ä‚¢‚邱‚Æ‚ª‚í‚©‚Á‚½Bˆê•ûC¬Šw¶‚Å‚ÍC•\î‚⺂̕ω»‚ðŠ´‚¶‚Â炢‚½‚ßC‹³Žt‘¤‚ªŠî‘b‚Ì”­º‚Ì—‰ð‚Ö“±‚«C‰Ì¥ŽÒ‚ª•\î‚ź‚ª•Ï‚í‚Á‚½‚ÆŠ´‚¶‚ç‚ê‚éŽw“±‚ª•K—v‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=KATAKAMISatomi en-aut-sei=KATAKAMI en-aut-mei=Satomi kn-aut-name=•Ðã‘”ü kn-aut-sei=•Ðã kn-aut-mei=‘”ü aut-affil-num=1 ORCID= en-aut-name=MUSHIAKIMasako en-aut-sei=MUSHIAKI en-aut-mei=Masako kn-aut-name=’Ž–¾áÁ»Žq kn-aut-sei=’Ž–¾ kn-aut-mei=áÁ»Žq aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRŽs—§‰ª“쬊wZ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È en-keyword=‰Ì¥ (singing) kn-keyword=‰Ì¥ (singing) en-keyword=•\î (facial expression) kn-keyword=•\î (facial expression) en-keyword=”­º (vocalization) kn-keyword=”­º (vocalization) en-keyword=Ίç (smiling face) kn-keyword=Ίç (smiling face) END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=2-3 article-no= start-page=131 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Eduald Bernstein, Ein Geleitwort zu Magyariens Schuld Ungarns S?hne : Revolution und Gegenrevolution in Ungarn von Oszk?r J?szi kn-title=ƒGƒhƒDƒAƒ‹ƒgEƒxƒ‹ƒ“ƒVƒ…ƒ^ƒCƒ“ uƒIƒXƒJ[ƒ‹Eƒ„[ƒV’˜wƒ}ƒWƒƒƒ‹‚ÌßCƒnƒ“ƒKƒŠ[‚Ìž‚¢ : ƒnƒ“ƒKƒŠ[‚É‚¨‚¯‚éŠv–½‚Æ”½Šv–½x‚ւ̘•¶v en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=‘¾“cmŽ÷ kn-aut-sei=‘¾“c kn-aut-mei=mŽ÷ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=1 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs en-subtitle= kn-subtitle= en-abstract= kn-abstract= Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings. en-copyright= kn-copyright= en-aut-name=ChenYuehua en-aut-sei=Chen en-aut-mei=Yuehua kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=XingBoyi en-aut-sei=Xing en-aut-mei=Boyi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=QiJiping en-aut-sei=Qi en-aut-mei=Jiping kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsukawaAkihiro en-aut-sei=Matsukawa en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Pathology, the First Affiliated Hospital of Harbin Medical University kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=cancer stem cell kn-keyword=cancer stem cell en-keyword=stemness kn-keyword=stemness en-keyword=iron kn-keyword=iron en-keyword=chelation kn-keyword=chelation en-keyword=chemotherapy kn-keyword=chemotherapy END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=1 article-no= start-page=123 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201904 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Validation of Addenbrooke's cognitive examination III for detecting mild cognitive impairment and dementia in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND:Early detection of mild cognitive impairment (MCI) and dementia is very important to begin appropriate treatment promptly and to prevent disease exacerbation. We investigated the screening accuracy of the Japanese version of Addenbrooke's Cognitive Examination III (ACE-III) to diagnose MCI and dementia.
METHODS:The original ACE-III was translated and adapted to Japanese. It was then administered to a Japanese population. The Hasegawa Dementia Scale-revised (HDS-R) and Mini-mental State Examination (MMSE) were also applied to evaluate cognitive dysfunction. In total, 389 subjects (dementia?=?178, MCI?=?137, controls?=?73) took part in our study.
RESULTS:The optimal ACE-III cut-off scores to detect MCI and dementia were 88/89 (sensitivity 0.77, specificity 0.92) and 75/76 (sensitivity 0.82, specificity 0.90), respectively. ACE-III was superior to HDS-R and MMSE in the detection of MCI or dementia. The internal consistency, test-retest reliability, and inter-rater reliability of ACE-III were excellent.
CONCLUSIONS:ACE-III is a useful cognitive test to detect MCI and dementia. ACE-III may be widely useful in clinical practice. en-copyright= kn-copyright= en-aut-name=TakenoshitaShintaro en-aut-sei=Takenoshita en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TeradaSeishi en-aut-sei=Terada en-aut-mei=Seishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshidaHidenori en-aut-sei=Yoshida en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamaguchiMegumi en-aut-sei=Yamaguchi en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YabeMayumi en-aut-sei=Yabe en-aut-mei=Mayumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ImaiNao en-aut-sei=Imai en-aut-mei=Nao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HoriuchiMakiko en-aut-sei=Horiuchi en-aut-mei=Makiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MikiTomoko en-aut-sei=Miki en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YokotaOsamu en-aut-sei=Yokota en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamadaNorihito en-aut-sei=Yamada en-aut-mei=Norihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Addenbrookefs cognitive examination kn-keyword=Addenbrookefs cognitive examination en-keyword=Cognitive screening kn-keyword=Cognitive screening en-keyword=Diagnosis dementia kn-keyword=Diagnosis dementia en-keyword=Diagnosis mild cognitive impairment kn-keyword=Diagnosis mild cognitive impairment en-keyword=Mild cognitive impairment kn-keyword=Mild cognitive impairment END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=5 article-no= start-page=441 end-page=447 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Risk Factors for Postoperative Hematoma after Chest Wall Contouring for Female-to-Male Transsexuals: A Clinical Study en-subtitle= kn-subtitle= en-abstract= kn-abstract= Gender dysphoria is a condition in which a discrepancy between biological sex and gender identity causes distress. Many female-to-male transsexuals (FTMTS) are uncomfortable with female breasts. Chest wall contouring surgery is effective for obtaining a male-type chest, reducing mental stress, and increasing sexual satisfaction in such cases. At the Okayama University Hospital Gender Center, we have obtained positive results using an algorithm to determine the most appropriate surgical method for chest wall contouring in FTMTS patients. However, serious complications requiring reoperation, such as hematoma, may still occur. Postoperative hematomas were found in 15 (4.18%) of 358 FTMTS patients who underwent chest contouring surgery at our hospital between 2006 and 2018. Postoperative hematoma was examined retrospectively. The median time to the onset of hematoma was 7 (6-12) h after the initial surgery. The main blood vessels causing bleeding were those in the head-side skin flap region where visual confirmation was difficult and the perforator vessels from the pectoralis major muscle. Intraoperative bleeding and the operation time had a significant impact on the onset of postoperative hematoma. This is the first retrospective study that investigated the blood vessels and other factors contributing to postoperative hematoma development after chest wall contouring. en-copyright= kn-copyright= en-aut-name=WatanabeToshiyuki en-aut-sei=Watanabe en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakuraiToru en-aut-sei=Sakurai en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MukaiYuko en-aut-sei=Mukai en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NambaYuzaburo en-aut-sei=Namba en-aut-mei=Yuzaburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Plastic and Reconstructive Surgery,Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Plastic and Reconstructive Surgery,Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Plastic and Reconstructive Surgery,Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Plastic and Reconstructive Surgery,Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Gender Center, Okayama University Hospital kn-affil= en-keyword=female-to-male transsexuals kn-keyword=female-to-male transsexuals en-keyword=chest wall contouring kn-keyword=chest wall contouring en-keyword=postoperative hematoma kn-keyword=postoperative hematoma END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=3 article-no= start-page=269 end-page=272 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Contrast-enhanced Computed Tomography-Guided Percutaneous Cryoablation of Renal Cell Carcinoma in a Renal Allograft: First Case in Asia en-subtitle= kn-subtitle= en-abstract= kn-abstract= Nephron-sparing treatment should be offered whenever possible to avoid dialysis in allograph cases. Cryoablation is a new treatment option for treating small-sized renal cell cancer (RCCs). We report a case of RCC arising in a kidney allograft treated by cryoablation. To our knowledge, this is the first case in Asia of RCC in a renal allograft treated using cryoablation. Contrast-enhanced CT-guided percutaneous renal needle biopsy and cryoablation were used to identify the RCC, which could not be identified by other techniques. The postoperative course was uneventful. Contrast-enhanced CT also showed no recurrence or metastases at the 6-month follow-up. en-copyright= kn-copyright= en-aut-name=TsuboiIchiro en-aut-sei=Tsuboi en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraHiroyasu en-aut-sei=Fujiwara en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ArichiNaoko en-aut-sei=Arichi en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawamuraKasumi en-aut-sei=Kawamura en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaruyamaYuki en-aut-sei=Maruyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MitsuiYosuke en-aut-sei=Mitsui en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KubotaRisa en-aut-sei=Kubota en-aut-mei=Risa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=SakoTomoko en-aut-sei=Sako en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=TakamotoAtsushi en-aut-sei=Takamoto en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=WadaKoichiro en-aut-sei=Wada en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=WatanabeToyohiko en-aut-sei=Watanabe en-aut-mei=Toyohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=YanaiHiroyuki en-aut-sei=Yanai en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=KitagawaMasashi en-aut-sei=Kitagawa en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=TanabeKatsuyuki en-aut-sei=Tanabe en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=SugiyamaHitoshi en-aut-sei=Sugiyama en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=ShiinaHiroaki en-aut-sei=Shiina en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Urology, Shimane University, Faculty of Medicine kn-affil= affil-num=7 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=16 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=17 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=18 en-affil=Department of Pathology, Okayama University Hospital kn-affil= affil-num=19 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=20 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=21 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=22 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=23 en-affil=Department of Urology, Shimane University, Faculty of Medicine kn-affil= affil-num=24 en-affil=Department of Radiology, Okayama University Hospital kn-affil= affil-num=25 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=cryoablation kn-keyword=cryoablation en-keyword=partial nephrectomy kn-keyword=partial nephrectomy en-keyword=renal cell carcinoma kn-keyword=renal cell carcinoma en-keyword=renal allograft kn-keyword=renal allograft en-keyword=renal transplantation kn-keyword=renal transplantation END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1 article-no= start-page=51 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impact of Body Mass Index of Japanese Gallbladder Cancer Patients on their Postoperative Outcomes en-subtitle= kn-subtitle= en-abstract= kn-abstract=@We investigated the relationship between body mass index (BMI) and postoperative outcomes in 450 gallbladder cancer patients in Japan. We collected patient information, including sex, age, underlying disease, BMI, stage, surgery method, postoperative time to discharge, and postoperative Medicare fees, from the Japanese administrative database associated with the Diagnosis Procedure Combination system. We classified patient BMIs as underweight (BMI<18.5 kg/m2), normal (BMI?18.5 kg/m2 and <25 kg/m2) or overweight/obese (BMI?25 kg/m2), then investigated the relationship between these categories and two postoperative outcomes: time to discharge and postoperative Medicare fees. The median postoperative time to discharge was 12 days in all patients, and 12 days in each of the three weight groups (p=0.62, n.s.). The median postoperative Medicare fees from surgery until discharge were (USD): all patients, $5,002; underweight, $5,875; normal weight, $4,797; and overweight/obese, $5,179 (p=0.146, n.s.). A multivariate analysis with adjustment for competing risk factors revealed that BMI was not associated with increased risk of longer postoperative time to discharge (normal weight: HR 1.17, p=0.29; overweight/obese: HR 1.17, p=0.37) or higher postoperative Medicare fees (OR 0.99, p=0.86, n.s.). Thus, high BMI was not found to be a factor for poor postoperative outcomes in Japanese patients with gallbladder cancer. en-copyright= kn-copyright= en-aut-name=FujiiMasakuni en-aut-sei=Fujii en-aut-mei=Masakuni kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujimotoKenji en-aut-sei=Fujimoto en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YabeSyuntaro en-aut-sei=Yabe en-aut-mei=Syuntaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NasuJunichiro en-aut-sei=Nasu en-aut-mei=Junichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyaikeJiro en-aut-sei=Miyaike en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YoshiokaMasao en-aut-sei=Yoshioka en-aut-mei=Masao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiodeJunji en-aut-sei=Shiode en-aut-mei=Junji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MatsudaShinya en-aut-sei=Matsuda en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital kn-affil= affil-num=2 en-affil=Department of Public Health, University of Occupational and Environmental Health kn-affil= affil-num=3 en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital kn-affil= affil-num=4 en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital kn-affil= affil-num=5 en-affil=Department of Internal Medicine, Imabari Saiseikai General Hospital kn-affil= affil-num=6 en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital kn-affil= affil-num=7 en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital kn-affil= affil-num=8 en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital kn-affil= affil-num=9 en-affil=Department of Public Health, University of Occupational and Environmental Health kn-affil= en-keyword=body mass index kn-keyword=body mass index en-keyword=gallbladder cancer kn-keyword=gallbladder cancer en-keyword=surgery kn-keyword=surgery en-keyword=obesity kn-keyword=obesity END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Role of Kallikrein-Related Peptidases in Atopic Dermatitis en-subtitle= kn-subtitle= en-abstract= kn-abstract= Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD. en-copyright= kn-copyright= en-aut-name=MorizaneShin en-aut-sei=Morizane en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=atopic dermatitis kn-keyword=atopic dermatitis en-keyword=kallikrein-related peptidases kn-keyword=kallikrein-related peptidases en-keyword=epidermal barrier dysfunction kn-keyword=epidermal barrier dysfunction END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=1 article-no= start-page=137 end-page=153 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A non-symmetric diffusion process on the Wiener space en-subtitle= kn-subtitle= en-abstract= kn-abstract=We discuss a non-symmetric diffusion process on the Wiener space. The process we consider is generated by A = L + b, L being the Ornstein-Uhlenbeck operator and b being a vector ?eld. Under suitable integrability condition for b, we show the existence of associated diffusion process. We also investigate the domain of the generator. Further we consider a similar problem in the ?nite dimensional Euclidean space. en-copyright= kn-copyright= en-aut-name=ShigekawaIchiro en-aut-sei=Shigekawa en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Mathematics Graduate School of Science Kyoto University kn-affil= en-keyword=non-symmetric Dirichlet form kn-keyword=non-symmetric Dirichlet form en-keyword=Wiener space kn-keyword=Wiener space en-keyword=logarithmic Sobolev inequality kn-keyword=logarithmic Sobolev inequality en-keyword=generator domain kn-keyword=generator domain END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=137 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Current Multidisciplinary Approach to Fertility Preservation for Breast Cancer Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy. Six (35%) patients underwent oocyte cryopreservation, and 11 (65%) married patients opted for embryo cryopreservation. There were no pregnancies among the patients undergoing oocyte cryopreservation, whereas 3 (27%) of the patients who opted for embryo cryopreservation became pregnant. Two (12%) patients stopped endocrine therapy after 2 years in an effort to become pregnant, but their breast cancers recurred. Though the problem of fertility loss for breast cancer patients is important and we should assess the infertility risk for all patients, we should also consider the prognosis. In June 2016, we launched a prospective multicenter cohort study to evaluate the efficacy and safety of fertility preservation in greater detail. en-copyright= kn-copyright= en-aut-name=TakahashiYuko en-aut-sei=Takahashi en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShienTadahiko en-aut-sei=Shien en-aut-mei=Tadahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakamotoAi en-aut-sei=Sakamoto en-aut-mei=Ai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsuyumuYuko en-aut-sei=Tsuyumu en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshiokaRyo en-aut-sei=Yoshioka en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UnoMaya en-aut-sei=Uno en-aut-mei=Maya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HatonoMinami en-aut-sei=Hatono en-aut-mei=Minami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KochiMariko en-aut-sei=Kochi en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KawadaKengo en-aut-sei=Kawada en-aut-mei=Kengo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TsukiokiTakahiro en-aut-sei=Tsukioki en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwamotoTakayuki en-aut-sei=Iwamoto en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IkedaHirokuni en-aut-sei=Ikeda en-aut-mei=Hirokuni kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TairaNaruto en-aut-sei=Taira en-aut-mei=Naruto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=NakatsukaMikiya en-aut-sei=Nakatsuka en-aut-mei=Mikiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=DoiharaHiroyoshi en-aut-sei=Doihara en-aut-mei=Hiroyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Obstetrics and Gynecology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Nursing, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=12 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= affil-num=14 en-affil=Department of Palliative and Supportive Medicine, Okayama University Hospital kn-affil= affil-num=15 en-affil=Department of Obstetrics and Gynecology, Okayama University Hospital kn-affil= affil-num=16 en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital kn-affil= en-keyword=fertility preservation kn-keyword=fertility preservation en-keyword=multidisciplinary kn-keyword=multidisciplinary en-keyword=breast cancer kn-keyword=breast cancer en-keyword=young patients kn-keyword=young patients END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue= article-no= start-page=121 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180322 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Status of Subordinate Conjunctions in Japanese Grammar kn-title=•¶–@˜_‚É‚¨‚¯‚é]‘®Ú‘±ŽŒ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LiuXiaomei en-aut-sei=Liu en-aut-mei=Xiaomei kn-aut-name=—«¬–… kn-aut-sei=—« kn-aut-mei=¬–… aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue= article-no= start-page=137 end-page=156 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20171127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Modal Meanings of Noun Predicate Sentences Expressing Activity kn-title=‰^“®–¼ŽŒqŒê•¶‚̃‚[ƒ_ƒ‹‚ȈӖ¡‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MengLingyi en-aut-sei=Meng en-aut-mei=Lingyi kn-aut-name=–Зß? kn-aut-sei=–Ð kn-aut-mei=—ß? aut-affil-num=1 ORCID= affil-num=1 en-affil=The Graduate School of Humanities and Social Sciences Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=5 article-no= start-page=529 end-page=533 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201705 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The impact of chronic rhinosinusitis on long-term survival in lung transplantation recipients en-subtitle= kn-subtitle= en-abstract= kn-abstract=CONCLUSIONS: Chronic rhinosinusitis diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps 2012, not by computed tomography alone, is one of the prognostic factors affecting long-term survival in patients with lung transplantation. Endoscopic sinus surgery might play a beneficial role in the management of lung transplantation recipients with chronic rhinosinusitis. OBJECTIVE: To show the effect of paranasal sinus infection on post-lung transplantation survival. METHOD: Lung transplantation recipients were included in this study. Computed tomography was performed before and after lung transplantation. The severity of chronic rhinosinusitis was evaluated by Lund-Mackay scoring system. The survival rate was calculated by the Kaplan-Meier method. RESULTS: One hundred and forty-eight patients received lung transplantation for various indications. Chronic rhinosinusitis was found in 18.9% (28/148) of the lung transplantation recipients. Of 28 patients with chronic rhinosinusitis, seven patients underwent endoscopic sinus surgery due to persistent post-nasal drip. The recipients with chronic rhinosinusitis who did not receive endoscopic sinus surgery (n?=?21) showed a significantly lower survival rate as compared to the patients without chronic rhinosinusitis. There was no statistically significant difference in the survival rate between the recipients with (n?=?50) and without (n?=?98) paranasal sinus abnormality on computed tomography. en-copyright= kn-copyright= en-aut-name=KariyaShin en-aut-sei=Kariya en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkanoMitsuhiro en-aut-sei=Okano en-aut-mei=Mitsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OtoTakahiro en-aut-sei=Oto en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HigakiTakaya en-aut-sei=Higaki en-aut-mei=Takaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HarunaTakenori en-aut-sei=Haruna en-aut-mei=Takenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NodaYohei en-aut-sei=Noda en-aut-mei=Yohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Thoracic Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Lung transplant kn-keyword=Lung transplant en-keyword=bronchiolitis obliterans kn-keyword=bronchiolitis obliterans en-keyword=infection; pneumonia kn-keyword=infection; pneumonia en-keyword=survival rate kn-keyword=survival rate END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=137 end-page=139 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Expensive Medicine and Medical Finance kn-title=‚Šz–ò܂ƈã—Ãà­ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HamadaJun en-aut-sei=Hamada en-aut-mei=Jun kn-aut-name=•l“c~ kn-aut-sei=•l“c kn-aut-mei=~ aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Health Economics and Policy, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@ˆã—íôEˆã—ÃŒoÏŠw END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=83e end-page=91e dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Histologic Evaluation of Lymphaticovenular Anastomosis Outcomes in the Rat Experimental Model: Comparison of Cases with Patency and Obstruction en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND: Lymphaticovenular anastomosis plays an important role in the surgical treatment of lymphedema. The outcomes of lymphaticovenular anastomosis are evaluated based on changes in edema; however, isolated assessment of the anastomosis itself is difficult. The authors used an animal experimental model to conduct a detailed examination of histologic changes associated with lymphaticovenular anastomosis and determined the factors important for success. METHODS: The experimental lymphaticovenular anastomosis model was created using lumbar lymph ducts and iliolumbar veins of Wistar rats. The authors performed anastomosis under a microscope and reviewed postoperative histologic changes using optical and electron microscopy. In addition, electron microscopy and histology were used for detailed examination of the area in the vicinity of the anastomotic region in cases with patency and obstruction. RESULTS: The patency rates immediately after, 1 week after, and 1 month after lymphaticovenular anastomosis were 100 percent (20 of 20), 70 percent (14 of 20), and 65 percent, respectively. A detailed examination of the anastomotic region with electron microscopy revealed that, in cases with patency, there was no notable transformation of the endothelial cells, which formed a smooth layer. In contrast, in obstruction cases, the corresponding region of the endothelium was irregular in structure. CONCLUSIONS: Vessel obstruction after lymphaticovenular anastomosis may be associated with irregular arrangement of the endothelial layer, leading to exposure of subendothelial tissues and platelet formation. One part of the postoperative changes after anastomosis and a cause of obstruction were elucidated in this study. The authors' results may enable improvements in lymphaticovenular anastomosis by translating back to real clinical operations. en-copyright= kn-copyright= en-aut-name=OnodaSatoshi en-aut-sei=Onoda en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsumotoKumiko en-aut-sei=Matsumoto en-aut-mei=Kumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaKiyoshi en-aut-sei=Yamada en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Science, University of Okayama kn-affil= affil-num=2 en-affil=Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Science, University of Okayama kn-affil= affil-num=3 en-affil=Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Science, University of Okayama kn-affil= affil-num=4 en-affil=Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Science, University of Okayama kn-affil= END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=1 article-no= start-page=117 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Kautsky, Die moderne Nationalit?t kn-title=ƒJ[ƒ‹EƒJƒEƒcƒL[u‹ß‘ã‚Ì–¯‘°W’cv en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=‘¾“cmŽ÷ kn-aut-sei=‘¾“c kn-aut-mei=mŽ÷ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw–¼—_‹³Žö END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=137 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Discussion of Universal Design for Learning for Active Learning in the University. kn-title=‘åŠw‚̃AƒNƒeƒBƒuƒ‰[ƒjƒ“ƒOŒ^Žö‹Æ‚ɑΉž‚µ‚½ ƒ†ƒjƒo[ƒTƒ‹ƒfƒUƒCƒ“ŠÂ‹«‚ÉŠÖ‚·‚éˆêlŽ@ en-subtitle= kn-subtitle= en-abstract=@The purpose of this study was to review the literature on support for students with developmental disorders in exercise-style classes, and to discuss universal design for learning for active learning in the University. Outside class, it will be necessary in the future to write up the syllabus more, to provide opportunities to practice exercise-style such as a presentation, a group discussion, group works, to cultivate student-facilitators. Inside class, the support methods for person with autism such as making rules explicit, a visual support, the support of hypersensitivity will be helpful to support the students with senses of weakness of communication with others. kn-abstract=@‹ß”NC‘åŠw‹³ˆç‚Ì’†‚ʼn‰KŒ`Ž®‚ðŠÜ‚ÞƒAƒNƒeƒBƒuƒ‰[ƒjƒ“ƒOŒ^Žö‹Æ‚ª‘‰Á‚µ‚Ä‚¢‚éB‚±‚ÌŽö‹ÆŒ`‘Ô‚ÍC‘½‚­‚ÌŠw¶‚ÌŽå‘Ì“IE”\“®“I‚ÈŠwC‚ð‘£i‚·‚éã‚Å—LŒø‚Å‚ ‚éˆê•ûCŽ©•ÂǃXƒyƒNƒgƒ‰ƒ€á‚ª‚¢iASDj‚ÌŠw¶‚ð‚Í‚¶‚߃Rƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“‚ð‹êŽè‚Æ‚·‚éŠw¶‚ªŽö‹Æ‚ÉŽQ‰Á‚·‚éã‚Å‚Ì‘å‚«‚Èá•Ç‚Æ‚à‚Ȃ蓾‚éB–{e‚Å‚ÍC‰‰KŒ`Ž®‚ÌŽö‹Æ‚Ö‚ÌŽQ‰Á‚É¢“ï‚ðŽ‚‚ł ‚낤ASD ‚ÌŠw¶‚âC‚»‚ê‚É€‚¸‚éƒRƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“‚Ì‹êŽè‚ÈŠw¶‚Ö‚ÌŽx‰‡‚ðl—¶‚µ‚½C‘åŠw‹³ˆç‚̃†ƒjƒo[ƒTƒ‹ƒfƒUƒCƒ“ŠÂ‹«‚ɂ‚¢‚ÄCæs•¶Œ£‚ðŠTŠÏ‚µ‚È‚ª‚çlŽ@‚µ‚½B‚»‚Ì’†‚ÅCŽö‹ÆŠO‚É‚¨‚¯‚éŽx‰‡‚Æ‚µ‚ÄCƒVƒ‰ƒoƒX‹LÚ‚Ì”z—¶C‰‰KŒ`Ž®‚ð—ûK‚·‚é‹@‰ï‚Ì’ñ‹ŸCƒtƒ@ƒVƒŠƒe[ƒ^[‚Ì—{¬‚ɂ‚¢‚Äq‚ׂé‚Æ‹¤‚ÉCŽö‹Æ“à‚É‚¨‚¯‚éŽx‰‡‚Æ‚µ‚ÄC‹ï‘̉»E–¾Šm‰»CŒ©’Ê‚µ‚ðŽ‚½‚¹‚é”z—¶CŽ‹ŠoŽx‰‡CŠ´Šo‰ß•q‚ւ̑Ήž“™‚ɂ‚¢‚Äq‚×C‘ã‘Ö‰Û‘è‚Ö‚Ì’u‚«Š·‚¦‚ɂ‚¢‚Ä‚àŒ¾‹y‚µ‚½B en-copyright= kn-copyright= en-aut-name=HaradaShin en-aut-sei=Harada en-aut-mei=Shin kn-aut-name=Œ´“cV kn-aut-sei=Œ´“c kn-aut-mei=V aut-affil-num=1 ORCID= en-aut-name=EdahiroKazunori en-aut-sei=Edahiro en-aut-mei=Kazunori kn-aut-name=Ž}œA˜aŒ› kn-aut-sei=Ž}œA kn-aut-mei=˜aŒ› aut-affil-num=2 ORCID= affil-num=1 en-affil=Institute for education and student services, Okayama University kn-affil=‰ªŽR‘åŠw ‘SŠw‹³ˆçEŠw¶Žx‰‡‹@\ affil-num=2 en-affil=Institute for education and student services, Okayama University kn-affil=‰ªŽR‘åŠw ‘SŠw‹³ˆçEŠw¶Žx‰‡‹@\ en-keyword=ƒAƒNƒeƒBƒuƒ‰[ƒjƒ“ƒO (Active Learning) kn-keyword=ƒAƒNƒeƒBƒuƒ‰[ƒjƒ“ƒO (Active Learning) en-keyword=Šw‚т̃†ƒjƒo[ƒTƒ‹ƒfƒUƒCƒ“ (Universal Design for Learning) kn-keyword=Šw‚т̃†ƒjƒo[ƒTƒ‹ƒfƒUƒCƒ“ (Universal Design for Learning) en-keyword=”­’BႪ‚¢Šw¶Žx‰‡ (Support for Students with Developmental Disorders in Higher Education) kn-keyword=”­’BႪ‚¢Šw¶Žx‰‡ (Support for Students with Developmental Disorders in Higher Education) END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue=3 article-no= start-page=133 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=New Sources on Katsunari Sasaki, a Pioneer of Japanese Labor Movement in Northwestern United States kn-title=ƒAƒƒŠƒJ¼–k•”“ú–{lˆÚ–¯˜J“­‰^“®‚Ìæ‹ìŽÒA²X–ØŸ¬‚ÉŠÖ‚·‚éVŽ‘—¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurokawaKatsutoshi en-aut-sei=Kurokawa en-aut-mei=Katsutoshi kn-aut-name=•ìŸ—˜ kn-aut-sei=•ì kn-aut-mei=Ÿ—˜ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ƒ}ƒ‹ƒgƒtƒBƒŠƒAŠ´õÇ‚Ì—Õ°“I“Á’¥‚ÉŠÖ‚·‚錤‹† kn-title=Clinical Characteristics of Stenotrophomonas maltophilia Bacteremia: A Regional Report and a Review of a Japanese Case Series en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=EbaraHirotaka en-aut-sei=Ebara en-aut-mei=Hirotaka kn-aut-name=]Œ´O‹M kn-aut-sei=]Œ´ kn-aut-mei=O‹M aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=191 end-page=196 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Our experience with the significance of collaborative medical and dental surgeries at the Head and Neck Cancer Center, Okayama University Hospital kn-title=‰ªŽR‘åŠw•a‰@“ªèò•”‚ª‚ñƒZƒ“ƒ^[‚É‚¨‚¯‚éˆã‰ÈŽ•‰È‡“¯Žèp‚ÌŒ»ó‰ðÍ‚Æ‚»‚̈Ӌ` en-subtitle= kn-subtitle= en-abstract= kn-abstract=@@We have been collaborating with head and neck surgeons, plastic surgeons and oral surgeons in surgeries for many patients with head and neck carcinomasi especially oral carcinomasj since 2006i fiscal year 2005j. The Head and Neck Cancer Center was established at Okayama University Hospital in 2012. @This Center was the first of its kind at a national university hospital in Japan. @At the Center, 174 operations on head and neck carcinomas and 96 reconstructive operations were performed in 2014i fiscal yearj. @Medical and dental collaborative operations have been increasing almost every year since the 2005 fiscal year. There were 45 collaborative operations in the 2014 fiscal year, which included 30 cases of bone or metal plate reconstruction or plate reinforcement of the jaws. @There were 76 medical and dental collaborative operations in the 7 years before the establishment of the Center, with a mean of 10.9 operations per year. Since the establishment of the Center, there have been 112 cases over 3 years with a mean of 37.3 operations per year. The number of surgeries has been markedly increased by the establishment of the Head and Neck Cancer Center. en-copyright= kn-copyright= en-aut-name=MizukawaNobuyoshi en-aut-sei=Mizukawa en-aut-mei=Nobuyoshi kn-aut-name=…ì“W‹g kn-aut-sei=…ì kn-aut-mei=“W‹g aut-affil-num=1 ORCID= en-aut-name=OnodaTomoo en-aut-sei=Onoda en-aut-mei=Tomoo kn-aut-name=¬–ì“c—F’j kn-aut-sei=¬–ì“c kn-aut-mei=—F’j aut-affil-num=2 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name=¼–{—m kn-aut-sei=¼–{ kn-aut-mei=—m aut-affil-num=3 ORCID= en-aut-name=TakedaSeiko en-aut-sei=Takeda en-aut-mei=Seiko kn-aut-name=•“cÄŽq kn-aut-sei=•“c kn-aut-mei=ÄŽq aut-affil-num=4 ORCID= en-aut-name=NodaYouhei en-aut-sei=Noda en-aut-mei=Youhei kn-aut-name=–ì“c—m•½ kn-aut-sei=–ì“c kn-aut-mei=—m•½ aut-affil-num=5 ORCID= en-aut-name=OnodaSatoshi en-aut-sei=Onoda en-aut-mei=Satoshi kn-aut-name=¬–ì“c‘ kn-aut-sei=¬–ì“c kn-aut-mei=‘ aut-affil-num=6 ORCID= en-aut-name=FukushimaMai en-aut-sei=Fukushima en-aut-mei=Mai kn-aut-name=•Ÿ“‡–ƒˆß kn-aut-sei=•Ÿ“‡ kn-aut-mei=–ƒˆß aut-affil-num=7 ORCID= en-aut-name=TsumuraMunechika en-aut-sei=Tsumura en-aut-mei=Munechika kn-aut-name=’Ѻ@‹ß kn-aut-sei=’Ѻ kn-aut-mei=@‹ß aut-affil-num=8 ORCID= en-aut-name=TakeuchiTetsuo en-aut-sei=Takeuchi en-aut-mei=Tetsuo kn-aut-name=’|“à“N’j kn-aut-sei=’|“à kn-aut-mei=“N’j aut-affil-num=9 ORCID= en-aut-name=SugiyamaNarushi en-aut-sei=Sugiyama en-aut-mei=Narushi kn-aut-name=™ŽR¬Žj kn-aut-sei=™ŽR kn-aut-mei=¬Žj aut-affil-num=10 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name=–،Ҍh—T kn-aut-sei=–ØŒÒ kn-aut-mei=Œh—T aut-affil-num=11 ORCID= affil-num=1 en-affil=Departments of Oral and Maxillofacial Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[C Š{ŒûoÄŒšŠO‰È affil-num=2 en-affil=Departments of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŽ¨•@ˆôAE“ªèò•”ŠO‰È affil-num=3 en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŒ`¬ŠO‰È affil-num=4 en-affil=Departments of Oral and Maxillofacial Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŠ{ŒûoÄŒšŠO‰È affil-num=5 en-affil=Departments of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŽ¨•@ˆôAE“ªèò•”ŠO‰È affil-num=6 en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŒ`¬ŠO‰È affil-num=7 en-affil=Departments of Oral and Maxillofacial Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŠ{ŒûoÄŒšŠO‰È affil-num=8 en-affil=Departments of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŽ¨•@ˆôAE“ªèò•”ŠO‰È affil-num=9 en-affil=Departments of Dental Laboratory, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŽ•‰È‹ZHŽº affil-num=10 en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŒ`¬ŠO‰È affil-num=11 en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@“ªèò•”‚ª‚ñƒZƒ“ƒ^[CŒ`¬ŠO‰È en-keyword=“ªèò•”‚ª‚ñihead and neck carcinomaj kn-keyword=“ªèò•”‚ª‚ñihead and neck carcinomaj en-keyword=Œûo‚ª‚ñioral carcinomaj kn-keyword=Œûo‚ª‚ñioral carcinomaj en-keyword=“ªèò•”‚ª‚ñƒZƒ“ƒ^[iHead and Neck Cancer Centerj kn-keyword=“ªèò•”‚ª‚ñƒZƒ“ƒ^[iHead and Neck Cancer Centerj en-keyword=ˆã‰ÈŽ•‰È‡“¯Žèpicollaborative medical and dental surgeriesj kn-keyword=ˆã‰ÈŽ•‰È‡“¯Žèpicollaborative medical and dental surgeriesj en-keyword=Š{œÄŒšireconstructive operations of the jawj kn-keyword=Š{œÄŒšireconstructive operations of the jawj END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=“ûŠàŒ´”­‘ƒ‚Æãüâ|ƒŠƒ“ƒpß“]ˆÚ‘ƒ‚Å‚ÌALDH1‚Æ“]ŽÊˆöŽq‚Ì”­Œ»‚Í—\Œã—\‘ªˆöŽq‚ƂȂ蓾‚é‚© kn-title=Evaluation of aldehyde dehydrogenase 1 and transcription factors in both primary breast cancer and axillary lymph node metastases as a prognostic factor en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ItoMaiko en-aut-sei=Ito en-aut-mei=Maiko kn-aut-name=ˆÉ“¡–ƒˆßŽq kn-aut-sei=ˆÉ“¡ kn-aut-mei=–ƒˆßŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=2 article-no= start-page=131 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Autopsy Case of Bilateral Optic Nerve Aplasia with Microphthalmia: Neural Retina Formation Is Required for the Coordinated Development of Ocular Tissues en-subtitle= kn-subtitle= en-abstract= kn-abstract=Human congenital anomalies provide information that contributes to the understanding of developmental mechanisms. Here we report bilateral optic nerve aplasia (ONA) with microphthalmia in the autopsy of the cadaver of a 70-year-old Japanese female. The gross anatomical inspection of the brain showed a cotton thread-like cord in the presumed location of the optic nerve tract or chiasm. Histologically, no neural retina, optic nerve bundle or retinal central vessels were formed in the eye globe, and the retinal pigment cells formed rosettes. The cornea, iris, and lens were also histologically abnormal. Immunohistochemically, no retinal cells expressed beta III tubulin, and Pax6-immunoreactive cells were present in the ciliary non-pigmented epithelial cells. This case of ONA could be attributed to the agenesis of retinal projection neurons as a sequel to the disruption of neural retina development. The neural retina formation would coordinate the proper development of ocular tissues. en-copyright= kn-copyright= en-aut-name=OhuchiHideyo en-aut-sei=Ohuchi en-aut-mei=Hideyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaniguchiKaori en-aut-sei=Taniguchi en-aut-mei=Kaori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MiyaishiSatoru en-aut-sei=Miyaishi en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KonoHitomi en-aut-sei=Kono en-aut-mei=Hitomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujitaHirofumi en-aut-sei=Fujita en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=BandoTetsuya en-aut-sei=Bando en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FuchizawaChiharu en-aut-sei=Fuchizawa en-aut-mei=Chiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaniYuko en-aut-sei=Ohtani en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaniOsamu en-aut-sei=Ohtani en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Departments of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Departments of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama affil-num=8 en-affil= kn-affil=Department of Anatomy, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama affil-num=9 en-affil= kn-affil=Department of Anatomy, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama en-keyword=eye development kn-keyword=eye development en-keyword=human congenital anomalies kn-keyword=human congenital anomalies en-keyword=optic nerve aplasia kn-keyword=optic nerve aplasia en-keyword=microphthalmia kn-keyword=microphthalmia en-keyword=neural retina kn-keyword=neural retina END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=21 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of mucinous adenocarcinoma of the duodenum and literature review of 16 cases reported in Japan kn-title=Œ´”­«\“ñŽw’°”S‰tŠà‚̈ê—á\ –{–M•ñ16—á‚ÌŒŸ“¢\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@Primary mucinous adenocarcinoma of the duodenum is rare. Here we report a case we recently encountered, and we review 16 cases reported in Japan. An 82-year-old Japanese woman was admitted to our hospital complaining of abdominal pain and heartburn. An endoscopic examination revealed a Type 2 tumor in the descending limb of the duodenum, and endoscopically obtained specimens revealed a poorly differentiated adenocarcinoma. We performed a curative pancreatoduodenectomy with lymph node resection, and the surgical specimen revealed that the duodenum was the primary site of the mucinous adenocarcinoma. The patient is currently alive „ 1 year after the operation without any evidence of recurrence. Of the 16 patients reviewed, all patients had advanced tumors those depth were T3-T4. 9 patients had lymph node metastasis and 4 patients had peritoneal dissemination at the time of surgery. Since mucinous adenocarcinoma of the duodenum is often progressive cancer at a diagnosis, which is tend to have a worse prognosis than other histological types. en-copyright= kn-copyright= en-aut-name=HamanoIkumi en-aut-sei=Hamano en-aut-mei=Ikumi kn-aut-name=•l–ìˆè”ü kn-aut-sei=•l–ì kn-aut-mei=ˆè”ü aut-affil-num=1 ORCID= en-aut-name=MatsumotoYusuke en-aut-sei=Matsumoto en-aut-mei=Yusuke kn-aut-name=¼–{—S‰î kn-aut-sei=¼–{ kn-aut-mei=—S‰î aut-affil-num=2 ORCID= en-aut-name=EndoYoshikatsu en-aut-sei=Endo en-aut-mei=Yoshikatsu kn-aut-name=‰““¡–FŽ kn-aut-sei=‰““¡ kn-aut-mei=–FŽ aut-affil-num=3 ORCID= en-aut-name=WatanabeNaoki en-aut-sei=Watanabe en-aut-mei=Naoki kn-aut-name=“nç²’¼Ž÷ kn-aut-sei=“nç² kn-aut-mei=’¼Ž÷ aut-affil-num=4 ORCID= en-aut-name=KaiKyouhei en-aut-sei=Kai en-aut-mei=Kyouhei kn-aut-name=b”㋱•½ kn-aut-sei=b”ã kn-aut-mei=‹±•½ aut-affil-num=5 ORCID= en-aut-name=SatoShizou en-aut-sei=Sato en-aut-mei=Shizou kn-aut-name=²“¡ŽlŽO kn-aut-sei=²“¡ kn-aut-mei=ŽlŽO aut-affil-num=6 ORCID= en-aut-name=WaniYoji en-aut-sei=Wani en-aut-mei=Yoji kn-aut-name=˜am—mŽ¡ kn-aut-sei=˜am kn-aut-mei=—mŽ¡ aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=•P˜HÔ\Žš•a‰@@ŠO‰È affil-num=2 en-affil= kn-affil=•P˜HÔ\Žš•a‰@@ŠO‰È affil-num=3 en-affil= kn-affil=•P˜HÔ\Žš•a‰@@ŠO‰È affil-num=4 en-affil= kn-affil=•P˜HÔ\Žš•a‰@@ŠO‰È affil-num=5 en-affil= kn-affil=•P˜HÔ\Žš•a‰@@ŠO‰È affil-num=6 en-affil= kn-affil=•P˜HÔ\Žš•a‰@@ŠO‰È affil-num=7 en-affil= kn-affil=•P˜HÔ\Žš•a‰@@•a—f’f‰È en-keyword=Œ´”­«\“ñŽw’°Šàiprimary duodenal cancerj kn-keyword=Œ´”­«\“ñŽw’°Šàiprimary duodenal cancerj en-keyword=”S‰tŠàimucinous carcinomaj kn-keyword=”S‰tŠàimucinous carcinomaj en-keyword=äX“ª\“ñŽw’°Øœipancreatoduodenectomyj kn-keyword=äX“ª\“ñŽw’°Øœipancreatoduodenectomyj END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=13 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current state of and views regarding clinical approarches to Helicobacter pylori infection kn-title=Helicobacter pylori Š´õf—Â̌»‹µ‚Æ“W–] en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=‰ª“c—T”V kn-aut-sei=‰ª“c kn-aut-mei=—T”V aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw en-keyword=Helicobacter pylori kn-keyword=Helicobacter pylori en-keyword=œ‹Û—Ö@ kn-keyword=œ‹Û—Ö@ en-keyword=ˆÝŠà kn-keyword=ˆÝŠà en-keyword=ˆÝ‰Š kn-keyword=ˆÝ‰Š en-keyword=MALT ƒŠƒ“ƒpŽî kn-keyword=MALT ƒŠƒ“ƒpŽî END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=2 article-no= start-page=133 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An investigator initiated phase II clinical trial of tamibarotene (AM80G) for chronic graft-versus-host disease kn-title=–«ˆÚA•Ð‘ÎhŽå•a‚ɑ΂·‚éƒ^ƒ~ƒoƒƒeƒ“iAM80Gj‚̈ãŽtŽå“±—Õ°‘æ‡U‘ŠŽŽŒ± en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name=¼X‹v˜a kn-aut-sei=¼X kn-aut-mei=‹v˜a aut-affil-num=1 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name=‘O“c‰ÃM kn-aut-sei=‘O“c kn-aut-mei=‰ÃM aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@ en-keyword=—Õ°Œ¤‹†’†Šj•a‰@ kn-keyword=—Õ°Œ¤‹†’†Šj•a‰@ en-keyword=–«GVHD kn-keyword=–«GVHD en-keyword=ƒ^ƒ~ƒoƒƒeƒ“ kn-keyword=ƒ^ƒ~ƒoƒƒeƒ“ en-keyword=“¯Ží‘¢ŒŒŠ²×–EˆÚA kn-keyword=“¯Ží‘¢ŒŒŠ²×–EˆÚA en-keyword=Th17 kn-keyword=Th17 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=3 article-no= start-page=137 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=201506 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Aberrant Expression of Keratin 7 in Hepatocytes as a Predictive Marker of Rapid Progression to Hepatic Failure in Asymptomatic Primary Biliary Cirrhosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patients? hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. en-copyright= kn-copyright= en-aut-name=SekiHiroyuki en-aut-sei=Seki en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaFusao en-aut-sei=Ikeda en-aut-mei=Fusao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NanbaShintaro en-aut-sei=Nanba en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoritouYuki en-aut-sei=Moritou en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakeuchiYasuto en-aut-sei=Takeuchi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YasunakaTetsuya en-aut-sei=Yasunaka en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OnishiHideki en-aut-sei=Onishi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MiyakeYasuhiro en-aut-sei=Miyake en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TakakiAkinobu en-aut-sei=Takaki en-aut-mei=Akinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NousoKazuhiro en-aut-sei=Nouso en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NakamuraMinoru en-aut-sei=Nakamura en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=2 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=3 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=4 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=5 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=6 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=7 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=8 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=9 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=10 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, affil-num=11 en-affil= kn-affil=Health Service Center, Okayama University affil-num=12 en-affil= kn-affil=Clinical Research Center, National Hospital Organization Nagasaki Medical Center affil-num=13 en-affil= kn-affil=Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, en-keyword=primary biliary cirrhosis kn-keyword=primary biliary cirrhosis en-keyword=keratin 7 kn-keyword=keratin 7 en-keyword=hepatic failure kn-keyword=hepatic failure END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=–³ÇŒó«PBCŠ³ŽÒ‚Ì—\Œã•s—Ç—á‚Ì‘Šú”­Œ©‚É‚¨‚¯‚éƒPƒ‰ƒ`ƒ“7õF‚Ì—L—p« kn-title=Aberrant Expression of Keratin 7 in Hepatocytes as a Predictive Marker of Rapid Progression to Hepatic Failure in Asymptomatic Primary Biliary Cirrhosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SekiHiroyuki en-aut-sei=Seki en-aut-mei=Hiroyuki kn-aut-name=蔎”V kn-aut-sei=è kn-aut-mei=”Ž”V aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=137 end-page=151 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150326 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Social Life Difficulties of Muslim Students in Japan kn-title=Ý“úƒ€ƒXƒŠƒ€—¯Šw¶‚̎Љﶊˆã‚Ì¢“ï en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakanoSachiko en-aut-sei=Nakano en-aut-mei=Sachiko kn-aut-name=’†–ìËŽq kn-aut-sei=’†–ì kn-aut-mei=ËŽq aut-affil-num=1 ORCID= en-aut-name=OkunishiYuri en-aut-sei=Okunishi en-aut-mei=Yuri kn-aut-name=‰œ¼—L— kn-aut-sei=‰œ¼ kn-aut-mei=—L— aut-affil-num=2 ORCID= en-aut-name=TanakaTomoko en-aut-sei=Tanaka en-aut-mei=Tomoko kn-aut-name=“c’†‹¤Žq kn-aut-sei=“c’† kn-aut-mei=‹¤Žq aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=158 cd-vols= no-issue= article-no= start-page=137 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Attempt to Guide a Womenfs Chorus Composed of Members of Various Occupations kn-title=‘½—l‚ÈEŽí‚ðŽ‚ƒƒ“ƒo[‚Å\¬‚³‚ꂽ—º‡¥’c‚̇¥Žw“±‚ÌŽŽ‚Ý en-subtitle= kn-subtitle= en-abstract= kn-abstract=@‘½—l‚ÈEŽí‚ðŽ‚‚h—º‡¥’c‚Ì’cˆõ‚ɑ΂·‚éˆÓŽ¯’²¸‚ðŠî‚ÉCŠˆ“®‚Ì–£—ÍC‹Zp–Ê‚âS g‚̕ω»‚ð•ªÍ‚µC‚³‚ç‚ÉŽdŽ–‚ւ̉e‹¿‚ɂ‚¢‚Ä‚àŒŸ“¢‚µ‚½Œ‹‰ÊC5 “_‚ɂ܂Ƃ߂邱‚Æ‚ª‚Å ‚«‚½B‡@Šˆ“®‚Ì“®‹@‚â–£—Í‚ÍC’cˆõŠeŽ©‚̇¥‚ւ̈¤DSC’cˆõ‘ŠŒÝ‚âŽw“±ŽÒ‚Æ‚ÌM—ŠŠÖŒWC ŽÐ‰ï“I‚ÈŽx‰‡‚âvŒ£‚Ì‹¤Š´“™‚Å‚ ‚éB‡A_“î‘Ì‘€‚âŒÄ‹z–@‚ÍCEêŠÂ‹«‚©‚燥Šˆ“®‚Ö‚ÌˆÓ Ž¯‚âSg‚Ì“]Š·‚Ìã‚Åd—v‚Å‚ ‚èCƒn[ƒ‚ƒj[‚âƒJƒmƒ“—ûK‚ÍCŽ¨‚ÌŒP—û‚Æ‚µ‚ÄŒø‰Ê‚ª‚ ‚éB ‡B’cˆõŠeŽ©‚̇¥‹Zp–ʂ̕ω»‚Å‚ÍC˜aºŠ´‚ÌŒüã‚Æ”­º‹Zp‚ÌŒüオ‘½‚­Œ©‚ç‚ꂽBˆÓŽ¯ –Ê‚Å‚ÍClŠÔŠÖŒW‚âŽÐ‰ï¶Šˆ“™‚ɉe‹¿‚ð—^‚¦‚Ä‚¢‚éBg‘Ì–Ê‚Å‚ÍC‘Ì‚ªŠyŠí‚É‚È‚é‚Æ‚¢‚¤Š´ Šo‚ª™X‚É—‰ð‚Å‚«‚é‚悤‚É‚È‚Á‚½B‡CŽdŽ–‚ւ̉e‹¿‚ɂ‚¢‚Ä‚ÍCŠˆ“®‚ð’Ê‚µ‚Ä‘OŒü‚«‚È‹C Ž‚¿‚ɂȂ邱‚Æ‚ªŽ©M‚ð[‚ßCŽdŽ–‚ւ̃‚ƒ`ƒx[ƒVƒ‡ƒ“‚ÌŒüã‚ɂ‚Ȃª‚éB‡DŽå‚ȉۑè‚Æ‚µ ‚ÄC’cˆõŒÂl‚ɑ΂µ‚Ä‚ÍC”­º‚̉ü‘P‚â—ûKŽžŠÔ‚ÌŠm•ÛC‡¥’c‚ɑ΂µ‚Ä‚ÍC’cˆõ‚Ì‘ˆõC ‡¥’c‚Ì•ûŒü«‚ÌŒŸ“¢‚â—ûK•û–@‚̉ü‘P‚ª‹“‚ª‚Á‚½B en-copyright= kn-copyright= en-aut-name=MushiakiMasako en-aut-sei=Mushiaki en-aut-mei=Masako kn-aut-name=’Ž–¾áÁ»Žq kn-aut-sei=’Ž–¾ kn-aut-mei=áÁ»Žq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰ÈŒ|p‹³ˆçŠwŒn en-keyword=‡¥ kn-keyword=‡¥ en-keyword=ƒn[ƒ‚ƒj[ kn-keyword=ƒn[ƒ‚ƒj[ en-keyword=ƒ`ƒƒƒŠƒeƒBƒRƒ“ƒT[ƒg kn-keyword=ƒ`ƒƒƒŠƒeƒBƒRƒ“ƒT[ƒg en-keyword=E‹Æ kn-keyword=E‹Æ en-keyword=’‡ŠÔ kn-keyword=’‡ŠÔ END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=159 end-page=163 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (30. combination with therapeutic drugs for chronic pain) kn-title=–ò•¨‘ŠŒÝì—p (30\–«áu’ÉŽ¡—Öò‚Ì‘ŠŒÝì—pj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OgawaAtsushi en-aut-sei=Ogawa en-aut-mei=Atsushi kn-aut-name=¬ì“Ö kn-aut-sei=¬ì kn-aut-mei=“Ö aut-affil-num=1 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=–k‘º‰À‹v kn-aut-sei=–k‘º kn-aut-mei=‰À‹v aut-affil-num=2 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=ç“°”Nº kn-aut-sei=ç“° kn-aut-mei=”Nº aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@–òÜ•” affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@–òÜ•” affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@–òÜ•” END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=137 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of asymptomatic right-sided adult Bochdalek hernia presented incidentally with rectal tumor kn-title=’¼’°ŽîᇂðŒ_‹@‚É”­Œ©‚³‚ꂽ–³Çó‚̬l‰E‘¤BochdalekEƒwƒ‹ƒjƒA‚Ì‚P—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=@We encountered a patient with an adult Bochdalek hernia discovered asymptomatically. A 77-year-old Japanese woman visited a local clinic with chief complaints of melena and difficulty in defecation. Based on the results of the detailed examination in our hospital, she was diagnosed with a rectal gastrointestinal stromal tumor (GIST) with a concurrent asymptomatic adult right-sided Bochdalek hernia. Because the tumor was large, laparoscopic abdominoperineal rectal amputation was performed after systemic imatinib therapy. During the surgery, we found a right diaphragmatic defect more than 13cm in long dia., through which the right hepatic lobe, colon, and greater omentum had prolapsed into the right thoracic cavity. No visceral adhesions were noted. No hernia sac was observed. Adult Bochdalek hernia is a relatively rare condition, and only three (incidentally discovered) cases of asymptomatic Bochdalek hernia, including the present case, have been reported in Japan. Here we provide a case report for the patient, who was followed-up without hernia surgery, plus a review of the literature. en-copyright= kn-copyright= en-aut-name=KatoHiroshi en-aut-sei=Kato en-aut-mei=Hiroshi kn-aut-name=‰Á“¡‘å kn-aut-sei=‰Á“¡ kn-aut-mei=‘å aut-affil-num=1 ORCID= en-aut-name=OishiMasahiro en-aut-sei=Oishi en-aut-mei=Masahiro kn-aut-name=‘åγ”Ž kn-aut-sei=‘åÎ kn-aut-mei=³”Ž aut-affil-num=2 ORCID= en-aut-name=KoderaMasahito en-aut-sei=Kodera en-aut-mei=Masahito kn-aut-name=¬Ž›³l kn-aut-sei=¬Ž› kn-aut-mei=³l aut-affil-num=3 ORCID= en-aut-name=YamamuraMasao en-aut-sei=Yamamura en-aut-mei=Masao kn-aut-name=ŽR‘º•û•v kn-aut-sei=ŽR‘º kn-aut-mei=•û•v aut-affil-num=4 ORCID= en-aut-name=IkedaHideaki en-aut-sei=Ikeda en-aut-mei=Hideaki kn-aut-name=’r“cG–¾ kn-aut-sei=’r“c kn-aut-mei=G–¾ aut-affil-num=5 ORCID= en-aut-name=MizunoKenji en-aut-sei=Mizuno en-aut-mei=Kenji kn-aut-name=…–쌛Ž¡ kn-aut-sei=…–ì kn-aut-mei=Œ›Ž¡ aut-affil-num=6 ORCID= en-aut-name=YamashitaYutaka en-aut-sei=Yamashita en-aut-mei=Yutaka kn-aut-name=ŽR‰º—T kn-aut-sei=ŽR‰º kn-aut-mei=—T aut-affil-num=7 ORCID= en-aut-name=SuzukiKazunori en-aut-sei=Suzuki en-aut-mei=Kazunori kn-aut-name=—é–؈ꑥ kn-aut-sei=—é–Ø kn-aut-mei=ˆê‘¥ aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=’¹ŽæŽs—§•a‰@@ŠO‰È affil-num=2 en-affil= kn-affil=’¹ŽæŽs—§•a‰@@ŠO‰È affil-num=3 en-affil= kn-affil=’¹ŽæŽs—§•a‰@@ŠO‰È affil-num=4 en-affil= kn-affil=’¹ŽæŽs—§•a‰@@ŠO‰È affil-num=5 en-affil= kn-affil=’¹ŽæŽs—§•a‰@@ŠO‰È affil-num=6 en-affil= kn-affil=’¹ŽæŽs—§•a‰@@ŠO‰È affil-num=7 en-affil= kn-affil=’¹ŽæŽs—§•a‰@@ŠO‰È affil-num=8 en-affil= kn-affil=’¹Žæ¶‹¦•a‰@@ŠO‰È en-keyword=¬lBochdalekEƒwƒ‹ƒjƒAiadult Bochdalek herniaj kn-keyword=¬lBochdalekEƒwƒ‹ƒjƒAiadult Bochdalek herniaj en-keyword=• o‹¾‰ºŽèpilaparoscopic surgeryj kn-keyword=• o‹¾‰ºŽèpilaparoscopic surgeryj END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=3 article-no= start-page=137 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=General Malaise and Physical Symptoms in Young Women with Untouched Toe en-subtitle= kn-subtitle= en-abstract= kn-abstract=Untouched toe is a condition in which a toe does not touch the ground while standing. It is frequently observed in women even under physiological conditions. Deformities or symptoms of the toes are not observed in these women. The clinical significance of untouched toe has not been fully elucidated. Two hundred young healthy women were recruited into the present study after informed consent. We evaluated the prevalence of untouched toe by measuring various indexes of the toe using a foot-sole-measuring equipment. We also conducted a self-administered questionnaire regarding general malaise. Untouched toe was observed in 114 of these 200 women (57.0%). The fifth toe was more frequently affected than the other toes. There were no significant differences in size of foot except the area and proportion touching the ground between women with untouched toe and those without untouched toe. The prevalence of general malaise was significantly higher in women with at least one untouched toe (57.0%) compared with those without untouched toe (43.0%) (pƒ0.05). Twelve symptoms\irritability, headache, tired eyes, hazy vision, congested or runny nose, irregular menstruation or menstrual pain, shoulder stiffness, neck stiffness, low back pain, cold hands, swollen feet, and cold feet\were more frequently observed in women with at least one untouched toe compared with those without untouched toes. Untouched toe was associated with various symptoms of general malaise. However, the pathological mechanism by which untouched toe causes these symptoms has not been determined. Further analysis of gait and exercise habits in women with untouched toe is necessary. en-copyright= kn-copyright= en-aut-name=AkamatsuMegumi en-aut-sei=Akamatsu en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakatsukaMikiya en-aut-sei=Nakatsuka en-aut-mei=Mikiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=cold feet kn-keyword=cold feet en-keyword=general malaise kn-keyword=general malaise en-keyword=shoulder stiffness kn-keyword=shoulder stiffness en-keyword=untouched toe kn-keyword=untouched toe en-keyword=young women kn-keyword=young women END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Žá”N—«‚Ì¢•‚‚«æ䣂ƕs’èD‘i‚ÌŠÖ˜A kn-title=General Malaise and Physical Symptoms in Young Women with Untouched Toe en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AkamatsuMegumi en-aut-sei=Akamatsu en-aut-mei=Megumi kn-aut-name=Ô¼Œb”ü kn-aut-sei=Ô¼ kn-aut-mei=Œb”ü aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue= article-no= start-page=100 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=2014 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Quality control of Photosystem II: The molecular basis for the action of FtsH protease and the dynamics of the thylakoid membranes en-subtitle= kn-subtitle= en-abstract= kn-abstract=The reaction center-binding D1 protein of Photosystem II is damaged by excessive light, which leads to photoinhibition of Photosystem II. The damaged D1 protein is removed immediately by specific proteases, and a metalloprotease FtsH located in the thylakoid membranes is involved in the proteolytic process. According to recent studies on the distribution and organization of the protein complexes/supercomplexes in the thylakoid membranes, the grana of higher plant chloroplasts are crowded with Photosystem II complexes and light-harvesting complexes. For the repair of the photodamaged D1 protein, the majority of the active hexameric FtsH proteases should be localized in close proximity to the Photosystem II complexes. The unstacking of the grana may increase the area of the grana margin and facilitate easier access of the FtsH proteases to the damaged D1 protein. These results suggest that the structural changes of the thylakoid membranes by light stress increase the mobility of the membrane proteins and support the quality control of Photosystem II. en-copyright= kn-copyright= en-aut-name=Yoshioka-NishimuraMiho en-aut-sei=Yoshioka-Nishimura en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamotoYasusi en-aut-sei=Yamamoto en-aut-mei=Yasusi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University en-keyword=Photosystem II kn-keyword=Photosystem II en-keyword=Light stress kn-keyword=Light stress en-keyword=FtsH protease kn-keyword=FtsH protease en-keyword=Grana kn-keyword=Grana en-keyword=Thylakoid kn-keyword=Thylakoid END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages kn-title=“œ”A•a‚Ìt‘Ÿ‚É‚¨‚¢‚Ächolecystokinin‚̓}ƒNƒƒtƒ@[ƒW‚ɑ΂·‚éR‰ŠÇì—p‚ð‰î‚µ‚½V‹K‚Ì•ÛŒìŒø‰Ê‚ð”­Šö‚·‚é en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyamotoSatoshi en-aut-sei=Miyamoto en-aut-mei=Satoshi kn-aut-name=‹{–{‘ kn-aut-sei=‹{–{ kn-aut-mei=‘ aut-affil-num=1 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name=Žl•ûŒ«ˆê kn-aut-sei=Žl•û kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= en-aut-name=MiyasakaKyoko en-aut-sei=Miyasaka en-aut-mei=Kyoko kn-aut-name=‹{â‹žŽq kn-aut-sei=‹{â kn-aut-mei=‹žŽq aut-affil-num=3 ORCID= en-aut-name=OkadaShinichi en-aut-sei=Okada en-aut-mei=Shinichi kn-aut-name=‰ª“ckˆê kn-aut-sei=‰ª“c kn-aut-mei=kˆê 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en-aut-name=Horiguchi SatoChikage en-aut-sei=Horiguchi Sato en-aut-mei=Chikage kn-aut-name=–xŒûçŒi kn-aut-sei=–xŒû kn-aut-mei=çŒi aut-affil-num=12 ORCID= en-aut-name=FunakoshiAkihiro en-aut-sei=Funakoshi en-aut-mei=Akihiro kn-aut-name=‘D‰zŒ°”Ž kn-aut-sei=‘D‰z kn-aut-mei=Œ°”Ž aut-affil-num=13 ORCID= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name=¼X‹v˜a kn-aut-sei=¼X kn-aut-mei=‹v˜a aut-affil-num=14 ORCID= en-aut-name=UchidaHaruhito Adam en-aut-sei=Uchida en-aut-mei=Haruhito Adam kn-aut-name=“à“cŽ¡m kn-aut-sei=“à“c kn-aut-mei=Ž¡m aut-affil-num=15 ORCID= en-aut-name=OgawaDaisuke en-aut-sei=Ogawa en-aut-mei=Daisuke kn-aut-name=¬ì‘å•ã kn-aut-sei=¬ì kn-aut-mei=‘å•ã aut-affil-num=16 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=ꠖ씎Žj kn-aut-sei=ê –ì kn-aut-mei=”ŽŽj aut-affil-num=17 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@tE–ƉuE“à•ª”å‘ãŽÓ“à‰ÈŠw affil-num=2 en-affil= 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kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@ŒŒ‰tEŽîá‡EŒÄ‹zŠí“à‰ÈŠw affil-num=15 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@tE–ƉuE“à•ª”å‘ãŽÓ“à‰ÈŠw affil-num=16 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@tE–ƉuE“à•ª”å‘ãŽÓ“à‰ÈŠw affil-num=17 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@tE–ƉuE“à•ª”å‘ãŽÓ“à‰ÈŠw en-keyword=cholecystokinin kn-keyword=cholecystokinin en-keyword=“œ”A•a«tÇ kn-keyword=“œ”A•a«tÇ en-keyword=R‰ŠÇì—p kn-keyword=R‰ŠÇì—p en-keyword=t•ÛŒìŒø‰Ê kn-keyword=t•ÛŒìŒø‰Ê END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=156 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hugo von Hofmannsthal und Richard Straussi1j kn-title=ƒz[ƒtƒ}ƒ“ƒXƒ^[ƒ‹‚ÆR. ƒVƒ…ƒgƒ‰ƒEƒXiˆêj \ƒ”ƒ@[ƒOƒi[‚©‚ç‚̉e‹¿‚ɂ‚¢‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyakeShinzou en-aut-sei=Miyake en-aut-mei=Shinzou kn-aut-name=ŽO‘îVŽO kn-aut-sei=ŽO‘î kn-aut-mei=VŽO aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page=133 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071027 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=“®‰æ‚âì‹Æ‚ð’Ê‚µ‚Ä‹ï‘Ì“I‚ÈŽ–Û‚Æ”Šw‚ðŒ‹‚Ñ‚Â‚¯‚éŽw“± \‘æ1Šw”N ”ä—á‚Æ”½”ä—á\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=•½–ìŒ\ˆê kn-aut-sei=•½–ì kn-aut-mei=Œ\ˆê aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRŽs—§—³‘€’†ŠwZ END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=2 article-no= start-page=131 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199003 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Seasonal prevalence and effect of temperature on the development of Ponticulothrips diospyrosi HAGA et OKAJlMA kn-title=ƒJƒLƒNƒ_ƒAƒUƒ~ƒEƒ}‚Ì”­¶Á’·‚Æ”­ˆç‚É‹y‚Ú‚·‰·“x‚̉e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UchiyamaKenji en-aut-sei=Uchiyama en-aut-mei=Kenji kn-aut-name=“àŽRŒ\“ñ kn-aut-sei=“àŽR kn-aut-mei=Œ\“ñ aut-affil-num=1 ORCID= en-aut-name=KawadaKazuo en-aut-sei=Kawada en-aut-mei=Kazuo kn-aut-name=‰Í“c˜a—Y kn-aut-sei=‰Í“c kn-aut-mei=˜a—Y aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=137 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=1930 dt-pub=19301031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=åa—t–I‚ÌŒ¤‹†i‘æŽl•ñj åa—t–I‚Ì–šŠúŠÔ‚É‹y‚Ú‚·‰·“x‚̉e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=tì’‰‹g kn-aut-sei=tì kn-aut-mei=’‰‹g aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ŒF‘ãŽO˜Y kn-aut-sei=ŒF‘ã kn-aut-mei=ŽO˜Y aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=3 article-no= start-page=137 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201305 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibition of arginase ameliorates experimental ulcerative colitis in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nitric oxide (NO) is produced from the conversion of L-arginine by NO synthase (NOS) and regulates a variety of processes in the gastrointestinal tract. Considering the increased activity of arginase in colitis tissue, it is speculated that arginase could inhibit NO synthesis by competing for the same L-arginine substrate, resulting in the exacerbation of colitis. We examined the role of arginase and its relationship to NO metabolism in dextran sulfate sodium (DSS)-induced colitis. Experimental colitis was induced in mice by administration of 2.5% DSS in drinking water for 8 days. Treatment for arginase inhibition was done by once daily intraperitoneal injection of N-omega-hydroxy-norarginine (nor-NOHA). On day 8, we evaluated clinical parameters (body weight, disease activity index, and colon length), histological features, the activity and expression of arginase, L-arginine content, the expression of NO synthase (NOS), and the concentration of NO end-product (NOx: nitrite + nitrate). Administration of nor-NOHA improved the worsened clinical parameters and histological features in DSS-induced colitis. Treatment with nor-NOHA attenuated the increased activity of arginase, upregulation of arginase. at both mRNA and protein levels, and decreased the content of L-arginine in colonic tissue in the DSS-treated mice. Conversely, despite the decreased expression of NOS2 mRNA, the decreased concentration of NOx in colonic tissues was restored to almost normal levels. The consumption of L-arginine by arginase could lead to decreased production of NO from NOS, contributing to the pathogenesis of the colonic inflammation; thus, arginase inhibition might be effective for improving colitis. en-copyright= kn-copyright= en-aut-name=AkazawaY. en-aut-sei=Akazawa en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KuboM. en-aut-sei=Kubo en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ZhangR. en-aut-sei=Zhang en-aut-mei=R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsumotoK. en-aut-sei=Matsumoto en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YanF. en-aut-sei=Yan en-aut-mei=F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SetiawanH. en-aut-sei=Setiawan en-aut-mei=H. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakahashiH. en-aut-sei=Takahashi en-aut-mei=H. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujikuraY. en-aut-sei=Fujikura en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OginoK. en-aut-sei=Ogino en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth affil-num=8 en-affil= kn-affil=Oita Univ, Fac Med, Dept Mol Anat affil-num=9 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth en-keyword=nitric oxide kn-keyword=nitric oxide en-keyword=N-omega-hydroxy-nor-L-arginine kn-keyword=N-omega-hydroxy-nor-L-arginine en-keyword=L-arginine kn-keyword=L-arginine en-keyword=NOx kn-keyword=NOx en-keyword=dextran sulfate sodium kn-keyword=dextran sulfate sodium END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=3 article-no= start-page=137 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=1962 dt-pub=196203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the metabolism of uronic acids. 3. Properties of an intermediate in pectic acid metabolism by Erwinia aroideae: Products by ozone and periodate Oxidation. kn-title=ƒEƒƒ“Ž_‚Ì‘ãŽÓ‚ÉŠÖ‚·‚錤‹†(3)@Erwinia aroideae‚É‚æ‚éƒyƒNƒ`ƒ“Ž_‚Ì‘ãŽÓ’†ŠÔ¶¬•¨‚Ì«Ž¿\ƒIƒ]ƒ“Ž_‰»‚Ɖߗ€‘fŽ_Ž_‰»‚É‚æ‚鶬•¨ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoK. en-aut-sei=Okamoto en-aut-mei=K. kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=1 ORCID= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=3 article-no= start-page=137 end-page=150 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19521201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=…“c趑ƒqƒ‘‚Ì–hœ‚ÉŠÖ‚·‚錤‹†@‘æ1•ñ@…âj‚Ì[…Í”|‚ªƒmƒrƒ‘‚Ì–hœ‹y‚Ñâj‚̶ˆç¾—Ê‚É‹y‚Ú‚·‰e‹¿i1j en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Š}Œ´ˆÀ•v kn-aut-sei=Š}Œ´ kn-aut-mei=ˆÀ•v aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=–؉º¾ kn-aut-sei=–؉º kn-aut-mei=¾ aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=3 article-no= start-page=137 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=1987 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=PROBING BEHAVIOUR OF THE APHID, SCHIZAPHIS GRAMINUM (RONDANI), RHOPALOSIPHUM MAIDIS (FITCH) AND LONGIUNGUIS SACCHARI (ZEHNTNER) ON RESISTANT AND SUSCEPTIBLE SORGHUM PLANTS en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LoharMohamad Khan en-aut-sei=Lohar en-aut-mei=Mohamad Khan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawadaKazuo en-aut-sei=Kawada en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=2 article-no= start-page=137 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350815 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Berichte über die Tätigkeit des Ausschusses für die Samen der warmen Klimate. Zwelte Mitteilung. Vergleichende Untersuchungen der Samen von Gossypium peruvianum, 1934. en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Kond?Mantar? en-aut-sei=Kond? en-aut-mei=Mantar? kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=123 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1923 dt-pub=19230701 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=åa‘ŽÖ–ä•a‚Ì•aŒ´ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Š}ˆäŠ²•v kn-aut-sei=Š}ˆä kn-aut-mei=Š²•v aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=151 cd-vols= no-issue= article-no= start-page=129 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pioneers in the Philosophy of Sport (2) kn-title=ƒXƒ|[ƒc“NŠw‚Ìæ‹ìŽÒ‚½‚¿i‚Qj en-subtitle= kn-subtitle= en-abstract= kn-abstract=–{e‚ÍŒ¤‹†W˜^147†ŒfÚ‚ÌuƒXƒ|[ƒc“NŠw‚Ìæ‹ìŽÒ‚½‚¿v‚É‘±‚­“à—e‚Å‚ ‚èC•MŽÒ‚̃Xƒ|[ ƒc“NŠw‚ÉŠÖ‚·‚錤‹†Œv‰æ‚̈ꕔ‚Ɉʒu‚¯‚ç‚ê‚éB–{e‚à‘Oe‚Æ“¯—l‚ɃXƒ|[ƒc‚ð“NŠw“I‚É ‰ðŽß‚µ‚½l•¨‚ÌŒ¾à‚ðCH. ƒŒƒ“ƒN‚Æ‚ÌŠÖŒW‚ðŽ‹–ì‚É“ü‚ê‚‚˜_‚¶‚éB‚»‚ê‚ÍCE. ƒwƒŠƒQƒ‹C H. ƒXƒ‰ƒbƒVƒƒ[CP. ƒƒCƒX‚Å‚ ‚éBƒŒƒ“ƒN‚Íu•“¹v‚»‚ꎩ‘Ì‚Ì•ªÍ‚ÉŠÖS‚ðŠñ‚¹‚Ä‚¢‚½ –ó‚Å‚Í‚È‚¢‚ªC’B¬ŠT”O‚Æ‘T“NŠw‚ð”äŠr‚·‚é“_‚ÉŠÖS‚ðŠñ‚¹‚Ä‚¢‚éBƒXƒ‰ƒbƒVƒƒ[‚ɂ‚¢‚Ä ‚ÍCƒXƒ|[ƒc‚ÌŽÀ‘¶Žå‹`“I‰ðŽß‚̈ê–ʶ‚ÆžB–†‚³‚Ì“_‚©‚ç”á”»‚³‚ê‚éBƒƒCƒX‚Ƃ̓Xƒ|[ƒc ‚ð“NŠw‚Ì‘ÎÛ‚Æ‚·‚鎖‚Ö‚Ì–â‘èˆÓŽ¯‚ð‹¤—L‚µ‚Ä‚¢‚½“_‚ªŽw“E‚Å‚«‚éB en-copyright= kn-copyright= en-aut-name=SekineMasami en-aut-sei=Sekine en-aut-mei=Masami kn-aut-name=ŠÖª³”ü kn-aut-sei=ŠÖª kn-aut-mei=³”ü aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È¶ŠˆEŒ’NƒXƒ|[ƒcŠwŒn en-keyword=‹|“¹ kn-keyword=‹|“¹ en-keyword=ŽÀÝŽå‹` kn-keyword=ŽÀÝŽå‹` en-keyword=‘ì‰z kn-keyword=‘ì‰z en-keyword=“NŠwŽj kn-keyword=“NŠwŽj END start-ver=1.4 cd-journal=joma no-vol=225 cd-vols= no-issue= article-no= start-page=137 end-page=140 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=NMR study for electrochemically inserted Na in hard carbon electrode of sodium ion battery en-subtitle= kn-subtitle= en-abstract= kn-abstract=The state of sodium inserted in the hard carbon electrode of a sodium ion battery having practical cyclability was investigated using solid state 23Na NMR. The spectra of carbon samples charged (reduced) above 50 mAh g?1 showed clear three components. Two peaks at 9.9 ppm and 5.2 ppm were ascribed to reversible sodium stored between disordered graphene sheets in hard carbon because the shift of the peaks was invariable with changing strength of external magnetic field. One broad signal at about ?9 to ?16 ppm was assigned to sodium in heterogeneously distributed closed nanopores in hard carbon. Low temperature 23Na static and magic angle spinning NMR spectra didn't split or shift whereas the spectral pattern of 7Li NMR for lithium-inserted hard carbon changes depending on the temperature. This strongly suggests that the exchange of sodium atoms between different sites in hard carbon is slow. These studies show that sodium doesn't form quasi-metallic clusters in closed nanopores of hard carbon although sodium assembles at nanopores while the cell is electrochemically charged. en-copyright= kn-copyright= en-aut-name=GotohKazuma en-aut-sei=Gotoh en-aut-mei=Kazuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshikawaToru en-aut-sei=Ishikawa en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShimadzuSaori en-aut-sei=Shimadzu en-aut-mei=Saori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YabuuchiNaoaki en-aut-sei=Yabuuchi en-aut-mei=Naoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KomabaShinichi en-aut-sei=Komaba en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakedaKazuyuki en-aut-sei=Takeda en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=GotoAtsushi en-aut-sei=Goto en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=DeguchiKenzo en-aut-sei=Deguchi en-aut-mei=Kenzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhkiShinobu en-aut-sei=Ohki en-aut-mei=Shinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HashiKenjiro en-aut-sei=Hashi en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ShimizuTadashi en-aut-sei=Shimizu en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IshidaHiroyuki en-aut-sei=Ishida en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science & Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Applied Chemistry, Tokyo University of Science affil-num=3 en-affil= kn-affil=Department of Applied Chemistry, Tokyo University of Science affil-num=4 en-affil= kn-affil=Department of Applied Chemistry, Tokyo University of Science affil-num=5 en-affil= kn-affil=Department of Applied Chemistry, Tokyo University of Science affil-num=6 en-affil= kn-affil=Division of Chemistry, Graduate School of Science, Kyoto University affil-num=7 en-affil= kn-affil=National Institute for Materials Science affil-num=8 en-affil= kn-affil=National Institute for Materials Science affil-num=9 en-affil= kn-affil=National Institute for Materials Science affil-num=10 en-affil= kn-affil=National Institute for Materials Science affil-num=11 en-affil= kn-affil=National Institute for Materials Science affil-num=12 en-affil= kn-affil=Graduate School of Natural Science & Technology, Okayama University en-keyword=Sodium ion battery kn-keyword=Sodium ion battery en-keyword=Anode kn-keyword=Anode en-keyword=Hard carbon kn-keyword=Hard carbon en-keyword=23Na kn-keyword=23Na en-keyword=Solid state NMR kn-keyword=Solid state NMR END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=137 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study for the structures of the HA complexes produced by Clostridium botulinum type A mutant strain kn-title=ƒ{ƒcƒŠƒkƒX‚`Œ^‹Û•ÏˆÙŠ”‚ªŽY¶‚·‚éHA•¡‡‘Ì‚Ì\‘¢‚ÉŠÖ‚·‚錤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clostridium botulinum produces seven neurotoxin (NTX) serotypes, classified from as A to G. In culture, NTX forms protein complexes by association with non-toxic components, such as nontoxic-nonhemagglutinin (NTNH) and hemagglutinins (HA1, HA2, HA3). C. botulinum serotype A produces three types of toxin complexes, M-toxin (NTX and NTNH), L-toxin (M-toxin and HAs) and LL-toxin (dimer of L-toxin). In this study, I found three HA complexes in the culture of a nontoxigenic mutant serotype A lacking ntx and ntnh expression. The HA complexes displayed similar banding patterns on SDS-PAGE, but the staining intensities of the HA1 and HA2 bands were different. In addition, their native-PAGE banding profiles exhibited different behaviors. The large-molecular-size HA complex showed the highest activity, similar to that of an L-toxin. Based on the combined results of the PAGE and gel-filtration profiles, the differences in molecular size among the three HA complexes were thought to be caused by different numbers of HA1 and HA2 molecules. This paper reports for the first time the purification and characterization of a native HA complex of serotype A, and suggests that the HA can form complex structures without NTX and NTNH. This may help in understanding the toxin complex assembly pathway. en-copyright= kn-copyright= en-aut-name=MaShaobo en-aut-sei=Ma en-aut-mei=Shaobo kn-aut-name=”n­”Ž kn-aut-sei=”n kn-aut-mei=­”Ž aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@•aŒ´×‹ÛŠw en-keyword=ƒ{ƒcƒŠƒkƒX“Å‘fibotulinum toxinj kn-keyword=ƒ{ƒcƒŠƒkƒX“Å‘fibotulinum toxinj en-keyword=ƒ{ƒcƒŠƒkƒX‹ÛiClostridium botulinumj kn-keyword=ƒ{ƒcƒŠƒkƒX‹ÛiClostridium botulinumj en-keyword=ŒŒ‹…‹ÃW‘fihemagglutininj kn-keyword=ŒŒ‹…‹ÃW‘fihemagglutininj en-keyword=ƒ^ƒ“ƒpƒNŽ¿•¡‡‘Ì\‘¢iprotein complex structurej kn-keyword=ƒ^ƒ“ƒpƒNŽ¿•¡‡‘Ì\‘¢iprotein complex structurej END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=137 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120326 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study of Pilgrimage to One Hundred Towers in Sankai-ki kn-title=wŽRžÅ‹Lx‚ÉŒ©‚ç‚ê‚é•S“ƒŽQ‚è‚̈êlŽ@ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LinHuiju en-aut-sei=Lin en-aut-mei=Huiju kn-aut-name=—Ñû›”@ kn-aut-sei=—Ñ kn-aut-mei=û›”@ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=53 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two cases of lymphoepithelial cyst of the pancreas kn-title=äXƒŠƒ“ƒpã”ç”X–E‚Ì2—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 35-year-old man was found to have a cystic mass in the pancreatic body on a routine health examination ; high serum CA19-9 was also detected. The enucleated cyst was diagnosed as a lymphoepithelial cyst (LEC). A 74-year-old man found to have a cystic mass in the pancreatic head by computer tomography as well as high serum CA19-9 was suspected of a cystic neoplasm of the pancreas (IPMN), and pylorus-preserving pancreaticoduodenectomy (PPPD) was performed. Pathologically, the cyst was found to be LEC. It is often difficult to diagnose pancreatic cyst as LEC preoperatively. Care should be taken not to do over-surgery for benign disease LEC. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=à_–ì—º•ã kn-aut-sei=à_–ì kn-aut-mei=—º•ã aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=ˆîŠ_—D kn-aut-sei=ˆîŠ_ kn-aut-mei=—D aut-affil-num=2 ORCID= en-aut-name=KimuraYuuji en-aut-sei=Kimura en-aut-mei=Yuuji kn-aut-name=–Ø‘º—SŽi kn-aut-sei=–Ø‘º kn-aut-mei=—SŽi aut-affil-num=3 ORCID= en-aut-name=IsodaKenta en-aut-sei=Isoda en-aut-mei=Kenta kn-aut-name=ˆé“cŒ’‘¾ kn-aut-sei=ˆé“c kn-aut-mei=Œ’‘¾ aut-affil-num=4 ORCID= en-aut-name=KitadaKoji en-aut-sei=Kitada en-aut-mei=Koji kn-aut-name=–k“c_“ñ kn-aut-sei=–k“c kn-aut-mei=_“ñ aut-affil-num=5 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=¼]Šw kn-aut-sei=¼] kn-aut-mei=Šw aut-affil-num=6 ORCID= en-aut-name=NomuraNagahisa en-aut-sei=Nomura en-aut-mei=Nagahisa kn-aut-name=–쑺’·‹v kn-aut-sei=–쑺 kn-aut-mei=’·‹v aut-affil-num=7 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=“¿‰i®”V kn-aut-sei=“¿‰i kn-aut-mei=®”V aut-affil-num=8 ORCID= en-aut-name=TakahashiKenji en-aut-sei=Takahashi en-aut-mei=Kenji kn-aut-name=‚‹´Œ’Ži kn-aut-sei=‚‹´ kn-aut-mei=Œ’Ži aut-affil-num=9 ORCID= en-aut-name=MiyasouHideaki en-aut-sei=Miyasou en-aut-mei=Hideaki kn-aut-name=‹{@G–¾ kn-aut-sei=‹{@ kn-aut-mei=G–¾ aut-affil-num=10 ORCID= en-aut-name=TsunemitsuYosuke en-aut-sei=Tsunemitsu en-aut-mei=Yosuke kn-aut-name=íŒõ—m•ã kn-aut-sei=íŒõ kn-aut-mei=—m•ã aut-affil-num=11 ORCID= en-aut-name=OhtsukaShinya en-aut-sei=Ohtsuka en-aut-mei=Shinya kn-aut-name=‘å’ËáÁÆ kn-aut-sei=‘å’Ë kn-aut-mei=áÁÆ aut-affil-num=12 ORCID= en-aut-name=MiyoshiKazuya en-aut-sei=Miyoshi en-aut-mei=Kazuya kn-aut-name=ŽOD˜a–ç kn-aut-sei=ŽOD kn-aut-mei=˜a–ç aut-affil-num=13 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=Šâì˜aG kn-aut-sei=Šâì kn-aut-mei=˜aG aut-affil-num=14 ORCID= en-aut-name=TakahashiMasahiko en-aut-sei=Takahashi en-aut-mei=Masahiko kn-aut-name=‚‹´³•F kn-aut-sei=‚‹´ kn-aut-mei=³•F aut-affil-num=15 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=ŠâŠ_”Ž–¤ kn-aut-sei=ŠâŠ_ kn-aut-mei=”Ž–¤ aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=2 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=3 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=4 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=5 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=6 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=7 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=8 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=9 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=10 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=11 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=12 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=13 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=14 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=15 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=16 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È en-keyword=ƒŠƒ“ƒpã”ç”X–E (lymphoepithelial cyst) kn-keyword=ƒŠƒ“ƒpã”ç”X–E (lymphoepithelial cyst) END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=427 article-no= start-page=845 end-page=850 dt-received= dt-revised= dt-accepted= dt-pub-year=1925 dt-pub=19250831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber einen Fall von "essentielle Thrombopenie" kn-title=“Á᢫ŒŒ¬”ÂŒ¸­Ç(Essentielle Thrombopenie)ƒjAƒe en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ein 42-j?hriger, kr?ftig gebauter Fischer soll seit etwa einem Jahre ohne nachweisbare Verlanassung Gingivalblutung und Hautpetechien bekommen haben. Bei der Aufnahme war er hochgradig blass und zeigte ziemlich ausgedehnte kleinfleckige Hautund Schleimhautblutung, ?dem an Unterschenkeln, und Zahnfleisch war angeschwollen und leicht blutend. Rote Blutzellen waren dabei 1,46 Millionen, darunter retikulierte Erythrozyten 1,6% (nach Robertson), weisse Blutzellen 3, 600 mit relativer Lymphozytose (49,0%), H?moglobin (nach Sahli) 31%, Blutpl?ttchen (nach Fonio) 31,900, Blutungszeit (nach Duke)15' und Gerinnungszeit (nach Sahli) 8'. Etwa 1 Monat lang wurde fast alle m?gliche interne Behandlung erfolglos ausgef?hrt und rote Blutzellen nahmen dazwischen bis 0,57 Mill., H?moglobin bis 16%, Blutpl?ttchen bis 12,420 (einmal sogar ganz vermisst) ab, und nach Duke blutete es noch nach 137 Minuten fort. Was es Endothelzelle betrifft, konnte ich, abgesehen von einem einzigen Exemplar grosser einkernigen Zelle (vielleicht Endothelzelle) in einem frischen Blutpr?parate aus Ohrl?ppchen, niemals solche Zelle, ja sogar keine Vermehrung von grossen Mononukle?ren in gef?rbten (mit Giemsa- Romanowsky) Ausstrichpr?paraten, welche aus Ohrl?ppchen und Fingerspitzen, sowohl nach Fingerdruck darauf als auch nach Adrenalininjektion, und auch aus Venenpunktata angefertigt wurden, konstatieren. Jedenfalls konnten wir nicht solche deutliche Losl?sung von Gef?ssendothelien bei meinem Fall von essentieller Thrombopenie beweisen, wie einst bei einem Fall von Endocarditis lenta mit h?morrhagischer Diathese nach Bittorf der Fall war. en-copyright= kn-copyright= en-aut-name=HasuikeT. en-aut-sei=Hasuike en-aut-mei=T. kn-aut-name=˜@’rꟖ¯ kn-aut-sei=˜@’r kn-aut-mei=Ꟗ¯ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{Š`À“à‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=123 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Implications for Zainichi Korean Research from a Review of Acculturation Attitudes and Cultural Identity in Overseas Immigrants (1) : Focusing on a Bidimensional Model of Acculturation and Psychological Variables kn-title=ŠCŠOˆÚ–¯‚Ì•¶‰»•Ï—e‘Ô“x‚Æ•¶‰»“IƒAƒCƒfƒ“ƒeƒBƒeƒBŒ¤‹†‚É‚Ý‚éÝ“úƒRƒŠƒAƒ“Œ¤‹†‚Ö‚ÌŽ¦´(1)F“ñŽŸŒ³ƒ‚ƒfƒ‹‚ÆS—Šw“I•Ï”‚ð’†S‚É en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LeeJung-hui en-aut-sei=Lee en-aut-mei=Jung-hui kn-aut-name=—›³•P kn-aut-sei=—› kn-aut-mei=³•P aut-affil-num=1 ORCID= en-aut-name=TanakaTomoko en-aut-sei=Tanaka en-aut-mei=Tomoko kn-aut-name=“c’†‹¤Žq kn-aut-sei=“c’† kn-aut-mei=‹¤Žq aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È”ŽŽmŒãŠú‰Û’ö affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È•¶‰»‹¤¶ŠwuÀ END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=239 end-page=241 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (22. opioid-drug interactions) kn-title=–ò•¨‘ŠŒÝì—pi22\ƒIƒsƒIƒCƒh‚Ì–ò•¨‘ŠŒÝì—pj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KawashimaRieko en-aut-sei=Kawashima en-aut-mei=Rieko kn-aut-name=쓇—ŒbŽq kn-aut-sei=쓇 kn-aut-mei=—ŒbŽq aut-affil-num=1 ORCID= en-aut-name=MatsunagaHisashi en-aut-sei=Matsunaga en-aut-mei=Hisashi kn-aut-name=¼‰i® kn-aut-sei=¼‰i kn-aut-mei=® aut-affil-num=2 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=ç“°”Nº kn-aut-sei=ç“° kn-aut-mei=”Nº aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@–òÜ•” affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@–òÜ•” affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@–òÜ•” END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=10 article-no= start-page=2067 end-page=2071 dt-received= dt-revised= dt-accepted= dt-pub-year=1928 dt-pub=19281031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Eine neue Diagnostik der Lepra auf Grund der sero-elektrischen Reaktion kn-title=ᚃmˆêfЖ@(“dŸ†‰j“®Œ»Û)ƒjAƒe en-subtitle= kn-subtitle= en-abstract= kn-abstract=Die Methode ist dieselbe wie die bei meinem Herpes-Versuche (S. diese Zeitschr. Bd. 40, Nr. 7). Der Kaninchenhoden, der mit der Emulsion des Lepraknotens inokuliert wurde, wurde 4 bis 5 Tage nach der Inokulation entnommen und mit 10 fachem absolutem Alkohol emulgiert. Die Emulsion wird beim Gebrauch mit 25 facher physiologischer Kochsalzl?sung verd?nnt und dann wird darauf ein Zehntel der Menge von inaktiviertem Krankenserum zugesetzt. Das Verfahren muss nach der Massnahme von Kosaka, Seki und Kumagai vorsichtig vorgenommen werden. (S. diese Zeitschr. Bd. 40 Nr. 1) Die Teilchen des Antigens wandern mit einer Geschwindigkeit von 3, 4ƒÊ pro Sekunde nach der Anode. Wenn man dem Antigen das normale Serum oder das Serum anderer Kranken zusetzt, vermindert sich die Geschwindigkeit bis auf 2, 61ƒÊ durchschnittlich. Dagegen vermindert das Lepraserum die Geschwindigkeit der Teilchen sehr bedeutend. Eine Geschwindigkeit der Teilchen geringer als 1, 8ƒÊ pro Sekunde wird als positive Reaktion bei Lepra betrachtet. Der Durchschnitt dieser Geschwindigkeit war 1, 37ƒÊ pro Sekunde. 137 Leprakranke best?tigten diese Resultate. Nur Syphilitiker m?ssen immer ausgeschlossen werden, denn sie zeigen eine positive Reaktion. Die Reaktion verh?lt sich in ganz der gleichen Weise bei Lepra tuberosa, maculosa, nervorum und mixta. Auch bei den infolge der Behandlung klinisch sehr verbesserten F?llen war die Reaktion noch positiv. Das Antigen wurde noch direkt aus der Emulsion des Lepraknotens oder aus dem Kaninchenhoden, der mit Leprablut injiziert wurde, hergestellt. Jedoch war das oben genannte Antigen am besten, und man kann ausserdem auf jene Wiese eine grosse Menge des Antigens auf einmal herstellen. en-copyright= kn-copyright= en-aut-name=EharaIchiro en-aut-sei=Ehara en-aut-mei=Ichiro kn-aut-name=]Œ´’–’m˜Y kn-aut-sei=]Œ´ kn-aut-mei=’–’m˜Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{”畆‰È”å”AŠí‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=137 end-page=139 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influenza-associated encephalopathy kn-title=¬Ž™‰È—̈æ‚É‚¨‚¯‚é“«Ž¾Š³ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MorishimaTsuneo en-aut-sei=Morishima en-aut-mei=Tsuneo kn-aut-name=X“‡P—Y kn-aut-sei=X“‡ kn-aut-mei=P—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@¬Ž™ˆã‰ÈŠw en-keyword=ƒCƒ“ƒtƒ‹ƒGƒ“ƒU kn-keyword=ƒCƒ“ƒtƒ‹ƒGƒ“ƒU en-keyword=ƒCƒ“ƒtƒ‹ƒGƒ“ƒU”]Ç kn-keyword=ƒCƒ“ƒtƒ‹ƒGƒ“ƒU”]Ç en-keyword=ƒKƒCƒhƒ‰ƒCƒ“ kn-keyword=ƒKƒCƒhƒ‰ƒCƒ“ en-keyword=‹}«”]Ç kn-keyword=‹}«”]Ç en-keyword=ƒTƒCƒgƒJƒCƒ“ kn-keyword=ƒTƒCƒgƒJƒCƒ“ END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=1 article-no= start-page=117 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1928 dt-pub=19280131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ueber die Lithioncarminf?rbung kn-title=uƒJƒ‹ƒ~ƒ“võFƒjAƒe en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. Bei dieser F?rbung spielt Salzs?urealkohol, welcher als Differenzierungsmittel gebraucht wird, keine einfache entf?rbende Rolle im Gegensats zur gew?hnlichen regressiven F?rbung, wobei das absichtlich ?berf?rbte Pr?parat im Differenzierungsmittel bis zum Optimum der F?rbung entf?rbt wird. Im Falle der Lithioncarminf?rbung findet die Adsorption des Farbstoffes auf den Schnitt erst dann statt, wenn man den letzteren in Salzs?urealkohol bringt, indem der Farbstoff aus seiner echten L?sung niederzuschlagen anf?ngt. Der gef?llte Farbstoff wird in Salzs?urealkohol wieder aufgel?st und im Verlauf der geeigneten Zeit bringt eine elektive Kernf?rbung mit sich. 2. Die Eigenschaft des Carmins ist mehr oder weniger verschieden je nach seiner Sorte, aber es ist im allgemeinen ganz unl?slich oder nur sehr schwerl?slich in Wasser, Alkohol und einer d?nnen S?urel?sung, w?hrend es sich in einer Alkoholl?sung der stark elektrolytischen metallischen und organischen S?uren relativ leicht und in einer alkalischen wasserigen L?sung wie Ammoniak -oder Lithiumcarbonatl?sung sehr leicht aufl?st. 3. Das Carmin ist kein Salz der Farbs?ure, wie dies beim sauren Anilinfarbstoffe der Fall ist, sondern es stellt einen Aluminiumlack der Carmins?ure dar, welcher in d?nnen sauren oder alkalischen L?sungen keine chemische Ver?nderung erf?hrt. Indessen findet man bei der Carminf?rbung manchmal eine Ver?nderung des Farbtons, was aber wahrscheinlich auf die Tautomerisation zur?ckzuf?hren ist. 4. Die Carmins?ure geh?rt zu den Anthracenfarbstoffen, so dass sie als Beizenfarbstoff angesehen werden kann. 5. Bei der Lithioncarminf?rbung wirkt Salzs?urealkohol auf die zweifache Weise u. z. erstens als Niederschlags-, zweitens als Aufl?sungsmittel, was die beste F?rbung zur Folge hat. 6. Zum Lithioncarmin wurden verschiedene Reagenzien hinzugef?gt, um Niederschlagsvorg?nge zu untersuchen. Es stellt sich heraus, dass der Niederschlag erstens auf dem Wege der direkten Neutralisierung des alkalischen Lithioncarmins mit S?uren, zweitens durch das indirekte Neutralisieren der alkalischen Farbl?sung mit gewissen Salzen wie Chlorcalcium, und drittens durch die Entziehung des L?sungsmittels zustande kommt. Dabei bildet sich der Niederschlag niemals aus Farbsalzen, sondern er ist nichts anderes als Carmin selbst. 7. Solche L?sung, welche auf das Lithioncarmin als Niederschlags- und zugleich als Aufl?sungsmittel wirken und daher sich zur Differenzierung empfehlen, sind folgende: 1. Salzs?urealkohol, 2. Salpeters?urealkohol, 3. Schhwefels?urealkohol, 4. Trichloressigs?urealkohol, 5. Sulfosalicyls?urealkohol, 6. Pikrius?urealkohol, 8. Was die Resultate, welche diese Differenzierungsmittel den gef?rbten Schnitten geben, anbelangt, so sind sie jedoch keineswegs gleich, und dieser Unterschied beruht haupts?chlich auf dem Dispersit?tsgrade des gel?sten Carmins im betreffenden Mittel, wie ich die Sache mit dem Colimeter bestimmt habe. Wenn man aber den Niederschlag des Lithioncarmins, welcher durch das lange Stehenlassen der Mischung der ?bersch?ssingen Farbl?sung mit jedem der genannten Differenzierungsmittel entsteht, untersucht, so sieht man, dass der Niederschlag ausnahmslos aus sehr feinen Teilchen besteht, so dass jede Mischung als Suspensoid angesehen werden kann. Angesichts dieser Tatsache glaube ich, dass alle genannte Differenzierungsmittel ein gutes Resultat geben k?nnen, wenn man nur ihre Konzentration und die Differenzierungszeit in richtiger Weise bestimmt. 9. Die genannten Differenzierungsmittel wurden so hergestellt, dass sie alle dieselbe Titrationsacidit?t mit dem Salzsaurealkohol haben konnten. Trotzdem weichen ihre Wirkungen auf das Lithioncarmin mehr oder weniger voneinander ab, wenn man in ihren Mischungen mit der Farbstoffl?sung den Dispersit?tsgrade der Farbstoffteilchen oder die Entstehungsweise des Niederschlages genau beobachtet. Dieser Unterschied ist hauptsachlich darauf zur?ckzuf?hren, dass verschiedene Anionen der S?uren dabei eine nicht untergeordenete Rolle spielen. Es unterliegt keinem Zweifel, dass die ausgezeichnete Wirkung des Salzs?urealkohols zum Teil auf dem Vorhandensein der Cl-Ionen beruht. 10. Wenn man einerseits die w?sserige, anderseits die alkoholische Saurel?sung derselben Konzentration bezuglich ihrer Wirkung auf das Lithioncarmin untersucht, so findet man einen grossen Unterschied zwischen beiden. Der Niederschlag, welcher in der w?sserigen L?sung entsteht, ist eine Koagulation im Gegensatz zum Niederschlag in der alkoholischen L?sung, welcher aus sehr feinen Teilchen besteht. Der erstere ist fast ganz unl?slich im Wasser, und seine Teilchen sind schwer adsorbierbar. w?hrend die Alkoholl?sung mit dem letzteren Niederschlag als Suspenscid angesehen werden kann. Daher liegt es auf der Hand, dass nicht die w?sserige, sondern die alkoholische S?urel?sung als Differenzierungsmittel gilt. 11. Es ist auf Grund der Reagenzglasuntersuchung bewiesen, dass die Lithioncarminf?rbung stets als sog. Niederschlagsf?rbung zustande kommt. 12. Die. Tatsache, dess bei der Lithioncarminf?rbung nur die Kernsubstanz im Gegensatz zum Protoplasma gef?rbt zutage tritt, beruht im Grunde genommen auf der chemischen Verschiedenheit beider Bestandteile, welche nach Fixierung eine voneinander abweichende physikalische Beschaffenheit, insbesondere eine verschiedene Dichtigkeit bekommen. Gerade diese physikalische Verschiedenheit gibt bei Differenzierung zur elektiven Kernf?rbung Anlass, wobei die chemische Affinitat keine hervorragende Rolle spielt. Daher f?rbt sich auch das Protoplasma, wenn man eine d?nnere Differenzierungsl?sung braucht, oder wenn die Differenzierungszeit nur zu kurz ist. 13. Was den Vorgang der vitalen Lithioncarminfarbung betrifft, so schliesse ich mich an Schulemann und M?llendorff an, welche die Niederschlagstheorie vertreten. Doch bin ich anderer Meinung ?ber die Ursache der Niederschlagbildung als die beiden Antoren. Das Protoplasma der vital f?rbbaren Zellen enth?lt wahrscheinlich viel Ca-Ionen, welche die Niederschlagung des Carmins begunstigen. en-copyright= kn-copyright= en-aut-name=MatsuuraSukehiko en-aut-sei=Matsuura en-aut-mei=Sukehiko kn-aut-name=¼‰Y•ã•F kn-aut-sei=¼‰Y kn-aut-mei=•ã•F aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{‰ð–U›{‹³Žº END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=1 article-no= start-page=137 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1929 dt-pub=19290131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the resisting power of spirochaete recurrens to the temperature, light and darkness kn-title=ÄŸd”MuƒXƒsƒƒw[ƒ^vƒg‰·“xâƒj–¾ˆÃƒmèŒWƒjAƒe en-subtitle= kn-subtitle= en-abstract= kn-abstract=The following facts were obtained by experiments about the relation between the inoculated mice or spirochaete recurrens and the temperature, light and darkness: 1) The length of the incubation period varies in accordance with the condition of the inoculated mice with spirochaete recurrens, that is in case it is heated (33-36‹C), or refrigerated (6-8‹C), or kept in the sunshine, in the darkness and in the room. 2) When heated, the incubation period is shorter than any other case, and when refrigerated, it is the longest of all. The mice being kept in the room or in the dark room, the incubation period is nearly the same. When the mice is exposed in the sunshine, the period seems to be longer than the experiment in the dark room on many occasions. 3) Spirochaete recurrens itself has a certain resisting power to the temperature, darkness and light; namely, its resistance is weak to the high temperature and sunshine but it has the longest life in the room. To the refrigeration its resistance is comparatively strong. 4) In the experiment of the inoculated mice, the increase of spirochaete is comparatively remarkable, in case the mice is heated. On the other hand, the increase is slow when refrigerated. As for me, in the spirochaete recurrens experiment the resistance is weak when heated, and strong when refrigerated. Thus, the result of the inoculated experiment apparently seems to be contrary to the spirochaete recurrens. en-copyright= kn-copyright= en-aut-name=MurayamaIseo en-aut-sei=Murayama en-aut-mei=Iseo kn-aut-name=‘ºŽRŒÜ£’j kn-aut-sei=‘ºŽR kn-aut-mei=ŒÜ£’j aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{”畆‰È”å”AŠí‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=2 article-no= start-page=63 end-page=69 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Outbreak of Salmonella Braenderup Infection Originating in Boxed Lunches in Japan in 2008 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There have been only 2 reports of a large-scale foodborne outbreak arising from Salmonella enterica serotype Braenderup infection worldwide. On August 9, 2008, an outbreak originating in boxed lunches occurred in Okayama, Japan. We conducted a cohort study of 786 people who received boxed lunches from a particular catering company and collected 644 questionnaires (response rate:82%). Cases were defined as those presenting with diarrhea (†4 times in 24h) or fever (†38Ž) between 12 am on August 8 and 12 am on August 14. We identified 176 cases (women/men:39/137);younger children (agedƒ10 years) appeared to more frequently suffer severe symptoms. Three food items were significantly associated with higher risk of illness;tamagotoji (soft egg with mixed vegetables and meat) (relative risk (RR):11.74, 95% confidence interval (CI):2.98-46.24), pork cooked in soy sauce (RR:3.17, 95% CI:1.24-8.10), and vinegared food (RR:4.13, 95% CI:1.60-10.63). Among them, only the RR of tamagotoji was higher when we employed a stricter case definition. Salmonella Braenderup was isolated from 5 of 9 sampled cases and 6 food handlers. It is likely that unpasteurized liquid eggs contaminated by Salmonella Braenderup and used in tamagotoji caused this outbreak. en-copyright= kn-copyright= en-aut-name=MizoguchiYoshinori en-aut-sei=Mizoguchi en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SuzukiEtsuji en-aut-sei=Suzuki en-aut-mei=Etsuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsuchidaHiroaki en-aut-sei=Tsuchida en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsudaToshihide en-aut-sei=Tsuda en-aut-mei=Toshihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamamotoEiji en-aut-sei=Yamamoto en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakaseKatsumi en-aut-sei=Nakase en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=DoiHiroyuki en-aut-sei=Doi en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Okayama City Public Health Center affil-num=4 en-affil= kn-affil=Department of Environmental Epidemiology, Okayama University Graduate School of Environmental Science affil-num=5 en-affil= kn-affil=Department of Information Science, Okayama University of Science affil-num=6 en-affil= kn-affil=Okayama City Public Health Center affil-num=7 en-affil= kn-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=boxed lunch kn-keyword=boxed lunch en-keyword=cohort study kn-keyword=cohort study en-keyword=foodborne diseases kn-keyword=foodborne diseases en-keyword=Salmonella Braenderup kn-keyword=Salmonella Braenderup en-keyword=unpasteurized liquid eggs kn-keyword=unpasteurized liquid eggs END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=1 article-no= start-page=33 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201102 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Usefulness of Computed Tomography in the Diagnosis of an Overdose en-subtitle= kn-subtitle= en-abstract= kn-abstract=Computed tomography (CT) is superior for the detection of substances with low radiolucency in comparison with abdominal roentgenograms. In the present study, medical chart review was retrospectively performed for patients who were admitted and underwent plain CT including the stomach on arrival to investigate whether CT is useful for diagnosing overdose (OD). The subjects were divided into patients with OD who did not undergo gastric lavage (OD group) and those without OD (Control group). The presence of a radiopaque area (Hounsfield number over 100 on a range of interest of 3mm2) in the stomach on CT was defined as a positive finding. The average Glasgow Coma Scale in the OD group (n11) was significantly lower than that in the Control group (n137). Positive findings on CT were found more frequently in the OD group than in the Control group (100 vs. 19.7%, pƒ0.0001). Based on the finding of a high-density deposition in the bottom of the stomach, the CT predicted OD with 98.5% specificity. Accordingly, CT findings of a high-density deposition in the stomach of a patient with a diminished consciousness may suggest the presence of a recent overdose. en-copyright= kn-copyright= en-aut-name=YanagawaYouichi en-aut-sei=Yanagawa en-aut-mei=Youichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishiKouichirou en-aut-sei=Nishi en-aut-mei=Kouichirou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ImamuraTomonori en-aut-sei=Imamura en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakamotoToshihisa en-aut-sei=Sakamoto en-aut-mei=Toshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Traumatology & Critical Care Medicine, National Defense Medical College (NDMC) Hospital affil-num=2 en-affil= kn-affil=Department of Traumatology & Critical Care Medicine, National Defense Medical College (NDMC) Hospital affil-num=3 en-affil= kn-affil=Department of Traumatology & Critical Care Medicine, National Defense Medical College (NDMC) Hospital affil-num=4 en-affil= kn-affil=Department of Traumatology & Critical Care Medicine, National Defense Medical College (NDMC) Hospital en-keyword=overdose kn-keyword=overdose en-keyword=diagnosis kn-keyword=diagnosis en-keyword=CT kn-keyword=CT END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=1 article-no= start-page=137 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and Clinical Study on the Bone Marrow Transplantation Part 2: The Co-relation between the recovery of experimental anemia due to bone marrow transplantation, iron metabolism and function of reticuloendothelial system kn-title=œé’–„Ÿ“‚ÉŠÖ‚·‚éŽÀŒ±“I•À‚É—Õ°“IŒ¤‹† ‘æ2•Ò œé’–„Ÿ“‚É‚æ‚éŽÀŒ±“I•nŒŒ‚̉ø•œ‚Æ“S‘ãŽÓ‹y‚Ñ–Ô“àŒn‹@”\‚Æ‚ÌŠÖŒW en-subtitle= kn-subtitle= en-abstract= kn-abstract=By inducing anemia in animals by such means as; blood-letting, phenylhydrazin injection, benzol injection, X-ray irradiation, kollargol injection, or anchylostoma; then, by performing Prokg. 0.5g bone marrow transplantation for those animals, obtatined results as follows: 1) The bone marrow transplantation has power to stimulate recovery from anemia; on that time, serum iron quantity proves a decrease, while function of reticuloendothelial system proves either excessive, or in case showing low, has room to be stirred up to recovery. 2) In general, the recovery of serum iron quantity to normal value is apt to be delayed compared to that of anemia 3) In kollargol anemic dog, the quantity of serum iron shows a marked increase. 4) The function of reticuloendothelial system with anchylostoma anemia shows a remarkable excitement, anemia cannot be recovered by sole bone marrow transplantation: it has not been recovered until helmintics has been employed; In case bone marrow transplantation and helmintic use have been performed at the same time, the blood cells keeps on to increase even after the recovery of anemia. en-copyright= kn-copyright= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=‰ª–ì‘ì–ç kn-aut-sei=‰ª–ì kn-aut-mei=‘ì–ç aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=1 article-no= start-page=137 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=19570131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistical Studies on the Parametritis and Peritonitis developing during Radiological Treatment in Cancer of the Uterine Cervix (Data of 21 years from 1934 to 1954 at the Dept. of Obstet. & Gynec., Okayama University) kn-title=Žq‹{èòŠà•úŽË—Ö@’†‚Ìœ”ÕŒ‹‡D‰Š•À‚Ñ‚É• –Œ‰Š‚Ì“Œv“IŠÏŽ@i‰ªŽR‘åŠwŽY•wl‰È‹³Žº‚ɉ—‚¯‚麘a9”N`29”N–˜‚Ì’²¸¬Ñj en-subtitle= kn-subtitle= en-abstract= kn-abstract=During twenty one years from 1934 to 1954, there were 1,974 patients of radiation therapy in the gynecological department of Okayama University. The authors made statistical observations on parametritis and peritonitis which developed during and after radiological treatment. Results obtained were as follows:- Parametritis, 211 cases (10.69%), peritonitis 132 cases (6.69%). The occurrence was higher in the war time (1943 to 1949), and thereafter it has gradually been decreasing in number. The onset started evidently often after the biginning of the radium treatment. It was clear that the patients were frequently observed in cases of advanced cancer, and the occurrence was higher in the patients less than 50 years of age. On the blood count, peritonitis had high incidence in cases of leucocytosis over 8,000 and showed high incidence in cases of high blood sedimentation rate (more than 100 mm an hour), and both had low incidence in the low rate (less than 39 mm an hour). It will be said that better effect is expectable by means of prophylaxis and adequate treatment of those inflammatory conditions using recently advanced antibiotics. en-copyright= kn-copyright= en-aut-name=SugaHazime en-aut-sei=Suga en-aut-mei=Hazime kn-aut-name={‰ê”£ kn-aut-sei={‰ê kn-aut-mei=”£ aut-affil-num=1 ORCID= en-aut-name=MitutaniSiro en-aut-sei=Mitutani en-aut-mei=Siro kn-aut-name=–ž’JŽm˜Y kn-aut-sei=–ž’J kn-aut-mei=Žm˜Y aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŽY•wl‰È‹³Žº affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŽY•wl‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=3 article-no= start-page=137 end-page=170 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19801205 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Theories of Keynesian Unemployment kn-title=ƒPƒCƒ“ƒY“IŽ¸‹Æ‚Ì—˜_‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IkeoKazuhito en-aut-sei=Ikeo en-aut-mei=Kazuhito kn-aut-name=’r”ö˜al kn-aut-sei=’r”ö kn-aut-mei=˜al aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=2 article-no= start-page=137 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Establishment of Subsidies for the Cities of Naval Arsenal - Documents on Naval Subsidies for Kure City - kn-title=ŠCŒRH±“sŽs‚É‚¨‚¯‚鑌ɕ¬‹à‚̬—§\ŒàŽs‚ÌŠCŒR•¬‹à‚ÉŠÖ‚·‚é‘—Þ‚ð‚ß‚®‚Á‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SakamotoChuji en-aut-sei=Sakamoto en-aut-mei=Chuji kn-aut-name=â–{’‰ŽŸ kn-aut-sei=â–{ kn-aut-mei=’‰ŽŸ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=1 article-no= start-page=137 end-page=179 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title="N?gy?shisonyashinaigusa" by Yoshitake Tokuyama, 1826 kn-title=“¿ŽRŒh–Ò w”_‹ÆŽq‘·—{ˆç‘x i•¶­‹ã”Nj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KandatsuHaruki en-aut-sei=Kandatsu en-aut-mei=Haruki kn-aut-name=_—§tŽ÷ kn-aut-sei=_—§ kn-aut-mei=tŽ÷ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=109 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840623 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Rural Industrial Policy in India kn-title=ƒCƒ“ƒh‚Ì”_‘ºH‹Æ­ô‚ɂ‚¢‚Ä\”_‘ºH‹ÆƒvƒƒWƒFƒNƒgiRIPjŒv‰æ‚ð’†S‚É\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MazaneKazumi en-aut-sei=Mazane en-aut-mei=Kazumi kn-aut-name=^ŽÀˆê”ü kn-aut-sei=^ŽÀ kn-aut-mei=ˆê”ü aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=3 article-no= start-page=137 end-page=161 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=19881130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Industrial Relations in the Japanese Automobile Industry (II) - A Case Study on Company B - kn-title=Ž©“®ŽÔŽY‹Æ‚̘JŽgŠÖŒWiIIj\BŽÐ‚ÌŽ–—ጤ‹†\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NomuraMasami en-aut-sei=Nomura en-aut-mei=Masami kn-aut-name=–쑺³›‰ kn-aut-sei=–쑺 kn-aut-mei=³›‰ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=1 article-no= start-page=137 end-page=170 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920526 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Gerhard Schmidt, kn-title=ƒQƒ‹ƒnƒ‹ƒgEƒVƒ…ƒ~ƒbƒgu‹ß‘ãƒUƒNƒZƒ“‘§Žj“ü–åviVj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuoNobushige en-aut-sei=Matsuo en-aut-mei=Nobushige kn-aut-name=¼”ö“W¬ kn-aut-sei=¼”ö kn-aut-mei=“W¬ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=4 article-no= start-page=137 end-page=154 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Development on Industry and Trade kn-title=ŽY‹Æ‚Æ–fˆÕ‚ÉŠÖ‚·‚éˆê“WŠJ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakemuraShosuke en-aut-sei=Takemura en-aut-mei=Shosuke kn-aut-name=•‘º¹‰î kn-aut-sei=•‘º kn-aut-mei=¹‰î aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=3 article-no= start-page=137 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19951212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Comparing the Three Credit Squeezes after the Shift to the Floating Exchange Rate System - A Rough Sketch - kn-title=•Ï“®‘Šê§“xˆÚsŒã‚ÌŽO“x‚Ì‹à—Zˆø’÷‚ß\ŠOŒ`‚Ì‘f•`\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IchinoseAtsushi en-aut-sei=Ichinose en-aut-mei=Atsushi kn-aut-name=ˆêƒm£“Ä kn-aut-sei=ˆêƒm£ kn-aut-mei=“Ä aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=3 article-no= start-page=137 end-page=165 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19961205 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Largest Industrials in Canada, 1975-1982 en-subtitle= kn-subtitle= en-abstract= kn-abstract=As was shown in the previous volume, I will show you the largest Canadian industrials from 1975 through 1982 in this volume. Data are based on "the world top 500 largest industrial companies outside the U. S." from Fortune Magazine. In the last part, I will also show you the breakdown of the largest Canadian Industrials from 1957 to 1982. en-copyright= kn-copyright= en-aut-name=EnomotoSatoru en-aut-sei=Enomoto en-aut-mei=Satoru kn-aut-name=‰|–{Œå kn-aut-sei=‰|–{ kn-aut-mei=Œå aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue=1 article-no= start-page=137 end-page=158 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title="Ikken Kuchigaki Utsushi" by Gisuke, 1837 (II) kn-title=[•BŠ‹üŒSã‹g‰H‘º] ˆêŒŒû‘ŽÊ “V•Û”ª“Ñ”N\“ñŒŽ ‹V•T i“ñj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KandatsuHaruki en-aut-sei=Kandatsu en-aut-mei=Haruki kn-aut-name=_—§tŽ÷ kn-aut-sei=_—§ kn-aut-mei=tŽ÷ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=3 article-no= start-page=137 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19991210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Fall-off of the Export of Rushen Matting to the United States kn-title=“ú–{‰Ô˜@‚̑΃AƒƒŠƒJ—Ao’â‘Ø‚ð‚ß‚®‚Á‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KandatsuHaruki en-aut-sei=Kandatsu en-aut-mei=Haruki kn-aut-name=_—§tŽ÷ kn-aut-sei=_—§ kn-aut-mei=tŽ÷ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue= article-no= start-page=137 end-page=156 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101124 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Risk of Using the "Public Domain" : The Outcomes of the Shane and Chaplin Copyright Case kn-title=Public Domain‚Ì’˜ì•¨‚ð—˜—p‚·‚邱‚Ƃ̃ŠƒXƒN\¢ƒVƒF[ƒ“£Ž–Œ‚ƃ`ƒƒƒbƒvƒŠƒ“Ž–Œ‚Ì”äŠr‚©‚番‚©‚邱‚Æ\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanakaHirokazu en-aut-sei=Tanaka en-aut-mei=Hirokazu kn-aut-name=“c’†G˜a kn-aut-sei=“c’† kn-aut-mei=G˜a aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Radiosensitivity of an isolated human malignant fibrous histiocytoma cell line kn-title=‘gD”|—{‚É‚æ‚élŠà×–Eiˆ««üˆÛ«‘gD‹…Žîj‚Ì•úŽËü‚ɑ΂·‚銴Žó«\‚»‚Ì1\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=A human cell line (YU-137) isolated from a bone of malignant fibrous histiocytoma in bone was evaluated using immunofluorescent staining methods. Cell cycle fractions were studied by flow cytometry. The magnitude of G(2)+M fraction in a cell cycle of an exponentially growing population of YU-137 was higher than that observed in HeLa S3 cells. The doubling time of YU-137 cells was 3.2 days. The radiosensitivity of this cell line was compared with HeLa S3 and HMV-1 cells from dose response curves against X-irradiation. The parameters of radiosensitivity of YU-137 against X-irradiation were n=2.0, D(0)=1.05 Gy and D(0)=0.73 Gy. From these data, the radiosensitivity of YU-137 was discussed. en-copyright= kn-copyright= en-aut-name=KawasakiShoji en-aut-sei=Kawasaki en-aut-mei=Shoji kn-aut-name=ìèË“ñ kn-aut-sei=ìè kn-aut-mei=Ë“ñ aut-affil-num=1 ORCID= en-aut-name=MizutaAkifumi en-aut-sei=Mizuta en-aut-mei=Akifumi kn-aut-name=…“cº•¶ kn-aut-sei=…“c kn-aut-mei=º•¶ aut-affil-num=2 ORCID= en-aut-name=KashitaniNaoko en-aut-sei=Kashitani en-aut-mei=Naoko kn-aut-name=”’J®Žq kn-aut-sei=”’J kn-aut-mei=®Žq aut-affil-num=3 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name=•“c¹G kn-aut-sei=•“c kn-aut-mei=¹G aut-affil-num=4 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=•½–ØË•v kn-aut-sei=•½–Ø kn-aut-mei=Ë•v aut-affil-num=5 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=–ì—v kn-aut-sei=–ì kn-aut-mei=—v aut-affil-num=6 ORCID= en-aut-name=SatoJiro en-aut-sei=Sato en-aut-mei=Jiro kn-aut-name=²“¡“ñ˜Y kn-aut-sei=²“¡ kn-aut-mei=“ñ˜Y aut-affil-num=7 ORCID= en-aut-name=OginoTetsuro en-aut-sei=Ogino en-aut-mei=Tetsuro kn-aut-name=‰¬–ì“N˜N kn-aut-sei=‰¬–ì kn-aut-mei=“N˜N aut-affil-num=8 ORCID= en-aut-name=NakanishiTakashi en-aut-sei=Nakanishi en-aut-mei=Takashi kn-aut-name=’†¼Œh kn-aut-sei=’†¼ kn-aut-mei=Œh aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•” affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•úŽËüˆãŠw‹³Žº affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•úŽËüˆãŠw‹³Žº affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•úŽËüˆãŠw‹³Žº affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•úŽËüˆãŠw‹³Žº affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•úŽËüˆãŠw‹³Žº affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŠàŒ¹Œ¤‹†Ž{Ý•a—Šw•”–å affil-num=8 en-affil= kn-affil=ìˆã‰È‘åŠw•a‰@•a—•” affil-num=9 en-affil= kn-affil=ŽRŒû‘åŠwˆãŠw•”•úŽËüˆãŠw‹³Žº en-keyword=Tissue culture kn-keyword=Tissue culture en-keyword=Malignant fibrous histeocytoma kn-keyword=Malignant fibrous histeocytoma en-keyword=Radiosensitivity kn-keyword=Radiosensitivity en-keyword=Flow cytometry kn-keyword=Flow cytometry END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue= article-no= start-page=10 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=195303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=CHEMICAL COMPOSITION OF SEKIGANE AND KAlKE HOT SPRINGS, TOTTORI PREFECTURE kn-title=ŠÖ‹à‰·ò‹y‚ÑŠF¶‰·ò‚ÌòŽ¿‚ÉA‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=The waters of six springs of Sekigane and one spring of Kaike were analyzed by the author in 1951. All the springs of Sekigane belong to the simple radioactilTe thermals. And Kaike Hot Spring belongs to a calcium chloride containing saline spring, its water temperature being 73,5Ž. The radon content of Sekigane Spring waters ranged from 57 to 137~10(-10) Curie units per liter. en-copyright= kn-copyright= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=Œä‘D­–¾ kn-aut-sei=Œä‘D kn-aut-mei=­–¾ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw?òŒ¤‹†Š‰»Šw•” END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=189 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinicopathological study of distal bile duct carcinoma at Fukuyama Medical Center kn-title=“–‰@‚É‚¨‚¯‚鉺•”’_ŠÇŠàŽèpÇ—á‚ÌŽ¡—Ã¬Ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced 20 patients with distal bile duct carcinoma from May, 1997 to December, 2007. The male/female ratio was 11/9 and the average age was 69.6 years. The operative procedures were as followsFpancreaticoduodenectomy (PD), 9Gpyrolus preserving pancreaticoduodenectomy (PPPD), 8Gsubtotal stomach preserving pancreaticoduodenectomy (SSPPD), 2 and hepatico-jejunostomy without resection, 1. We performed a clinicopathological study on 16 patients with distal bile duct carcinoma, excluding 3 operation-related deaths and 1 unresectable case. The cumulative survival rate was 70% at 3 years and 11% at 5 years. The 3-year survival rates at fStage‡U, fStage‡Wa and fStage‡Wb were 100%, 80% and 0%, respectively. Log-rank analysis revealed that pathological pancreatic and duodenal invasion and curative resectability may be prognostic factors, while lymph node metastasis and perineural and stump invasion did not affect prognosis. Six recurrences in the 11 curative resection cases (54.5%) were observedGtherefore, postoperative systemic chemotherapy is warranted to curtail recurrence in advanced distal bile duct carcinoma. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=à_–ì—º•ã kn-aut-sei=à_–ì kn-aut-mei=—º•ã aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=ˆîŠ_—D kn-aut-sei=ˆîŠ_ kn-aut-mei=—D aut-affil-num=2 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=¼]Šw kn-aut-sei=¼] kn-aut-mei=Šw aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=“¿‰i®”V kn-aut-sei=“¿‰i kn-aut-mei=®”V aut-affil-num=4 ORCID= en-aut-name=TsunemitsuYosuke en-aut-sei=Tsunemitsu en-aut-mei=Yosuke kn-aut-name=íŒõ—m•ã kn-aut-sei=íŒõ kn-aut-mei=—m•ã aut-affil-num=5 ORCID= en-aut-name=OhtsukaShinya en-aut-sei=Ohtsuka en-aut-mei=Shinya kn-aut-name=‘å’ËáÁÆ kn-aut-sei=‘å’Ë kn-aut-mei=áÁÆ aut-affil-num=6 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=Šâì˜aG kn-aut-sei=Šâì kn-aut-mei=˜aG aut-affil-num=7 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=ŠâŠ_”Ž–¤ kn-aut-sei=ŠâŠ_ kn-aut-mei=”Ž–¤ aut-affil-num=8 ORCID= en-aut-name=SonobeHiroshi en-aut-sei=Sonobe en-aut-mei=Hiroshi kn-aut-name=‰€•”G kn-aut-sei=‰€•” kn-aut-mei=G aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=2 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=3 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=4 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=5 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=6 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=7 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=8 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=9 en-affil= kn-affil=’†‘’†‰›•a‰@@—Õ°ŒŸ¸‰È en-keyword=‰º•”’_ŠÇŠà (distal bile duct carcinoma) kn-keyword=‰º•”’_ŠÇŠà (distal bile duct carcinoma) en-keyword=Žèp (operation) kn-keyword=Žèp (operation) en-keyword=—\Œã‹K’èˆöŽq (independent prognostic factors) kn-keyword=—\Œã‹K’èˆöŽq (independent prognostic factors) END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=159 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Japanese guidelines for coxarthrosis kn-title=•ÏŒ`«ŒÒŠÖßÇ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujiwaraKazuo en-aut-sei=Fujiwara en-aut-mei=Kazuo kn-aut-name=“¡Œ´ˆê•v kn-aut-sei=“¡Œ´ kn-aut-mei=ˆê•v aut-affil-num=1 ORCID= en-aut-name=EndoHirosuke en-aut-sei=Endo en-aut-mei=Hirosuke kn-aut-name=‰““¡—T‰î kn-aut-sei=‰““¡ kn-aut-mei=—T‰î aut-affil-num=2 ORCID= en-aut-name=MiyakeYoshiaki en-aut-sei=Miyake en-aut-mei=Yoshiaki kn-aut-name=ŽO‘î—RW kn-aut-sei=ŽO‘î kn-aut-mei=—RW aut-affil-num=3 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name=”öú±•q•¶ kn-aut-sei=”öú± kn-aut-mei=•q•¶ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@®Œ`ŠO‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@‰^“®Šíˆã—ÃÞ—¿ŠJ”­ affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@®Œ`ŠO‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@®Œ`ŠO‰È END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=135 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Foreword kn-title=Œ¾ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IwatsukiKeiji en-aut-sei=Iwatsuki en-aut-mei=Keiji kn-aut-name=ŠâŒŽŒ[Ž kn-aut-sei=ŠâŒŽ kn-aut-mei=Œ[Ž aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@”畆‰È END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=119 end-page=124 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Psycho-oncology F An overview kn-title=¸_ŽîᇊwŠT˜_ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UchitomiYosuke en-aut-sei=Uchitomi en-aut-mei=Yosuke kn-aut-name=“à•x—f‰î kn-aut-sei=“à•x kn-aut-mei=—f‰î aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@¸__Œo•a‘ÔŠw en-keyword=‚ª‚ñ kn-keyword=‚ª‚ñ en-keyword=ƒTƒCƒRƒIƒ“ƒRƒƒW[ kn-keyword=ƒTƒCƒRƒIƒ“ƒRƒƒW[ en-keyword=quality of life kn-keyword=quality of life en-keyword=ŠÉ˜aƒPƒA kn-keyword=ŠÉ˜aƒPƒA END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=11 article-no= start-page=3642 end-page=3647 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of heat-treatments on electrical properties of boron-doped silicon crystals en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The effects of heat-treatments around 1000‹‚band subsequent annealing on the electrical properties of boron-doped silicon have been studied by electrical conductivity, Hall effect, and deep-level transient spectroscopy measurements. The high-temperature heat-treatments always induced net densities of donors. Four recovery stages, stages I-IV, of heat-treatment- induced donors were observed on isochronal annealing up to 400‹‚b Conductivity changes in these stages can be explained as described below by the reactions of interstitial iron (Fei), its pair (Fe1Bs)with substitutional boron (Bs), and two unknown donors (D1, D2). That is, stage I (25‹-100‹‚b): D1¨sink and Fei + Bs¨FeiBs, stage II (100‹-150‹‚b)F FeiBs¨Fei + Bs, stage III (200‹-250‹‚b):D2¨sink, stage IV (250‹-350‹‚b)Fei¨precipitation. Heat-treatments in an oxygen atmosphere greatly reduced the introduction of Fei and FeiBs in comparison with an argon atmosphere and mainly introduced D1 and D2 donors. The density of D2 was dependent on the heat-treatment temperature, while that of D1 showed almost no dependence. In stage I, D, was annihilated by first-order kinetics with an activation energy of 0.8 eV. It was indicated that DI and D2 have no relations to iron, copper, oxygen, nor carbon. Though their origins are still unidentified, there may be some interstitial impurities. In stage IV, Fei is suggested to precipitate at oxygen precipitates and dislocation loops formed by high-temperature heat-treatments. As to the application to iron gettering in the device fabrication process, it is proposed that annealing around 300‹‚b is most suitable as the final heat-treatment step to remove iron and related defects from active regions of devices. Silicon wafers receive complex heat-treatments at various.

en-copyright= kn-copyright= en-aut-name=KamiuraY. en-aut-sei=Kamiura en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashimotoF. en-aut-sei=Hashimoto en-aut-mei=F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YonetaM. en-aut-sei=Yoneta en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=silicon kn-keyword=silicon en-keyword=crystals kn-keyword=crystals en-keyword=doping kn-keyword=doping en-keyword=boron kn-keyword=boron en-keyword=heat treatment kn-keyword=heat treatment en-keyword=annealing kn-keyword=annealing en-keyword=electrical conductivity measurement kn-keyword=electrical conductivity measurement END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=2 article-no= start-page=137 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=198212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A certain type of commutative Hopf Galois extensions and their groups en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakajimaAtsushi en-aut-sei=Nakajima en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=2 article-no= start-page=137 end-page=139 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=198112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Supplements to the previous paper "Some commutativity theorems for rings" en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiranoYasuyuki en-aut-sei=Hirano en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HonganMotoshi en-aut-sei=Hongan en-aut-mei=Motoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TominagaHisao en-aut-sei=Tominaga en-aut-mei=Hisao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Tsuyama College of Technology affil-num=3 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=1 article-no= start-page=137 end-page=151 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Non-immersion Result for Lens Spaces Ln(2m) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=JunodBernard en-aut-sei=Junod en-aut-mei=Bernard kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Universit? De Neuch?tel END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=2 article-no= start-page=137 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=197406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On some exponential sums involving the divisor function over arithmetical progressions en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UchiyamaSabur? en-aut-sei=Uchiyama en-aut-mei=Sabur? kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=1 article-no= start-page=133 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Global dimension and a question of Armendariz en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ParkJae Keol en-aut-sei=Park en-aut-mei=Jae Keol kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=RoggenkampKlaus W. en-aut-sei=Roggenkamp en-aut-mei=Klaus W. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Busan National University affil-num=2 en-affil= kn-affil=Busan National University END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=1 article-no= start-page=137 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Nonlinear Semigroups Analytic on Sectors en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakamuraGen en-aut-sei=Nakamura en-aut-mei=Gen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoToshitaka en-aut-sei=Matsumoto en-aut-mei=Toshitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OharuShinnosuke en-aut-sei=Oharu en-aut-mei=Shinnosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Matsue National College of Technology affil-num=2 en-affil= kn-affil=Hiroshima University affil-num=3 en-affil= kn-affil=Hiroshima University en-keyword=analytic semigroups kn-keyword=analytic semigroups en-keyword=boundary semigroups kn-keyword=boundary semigroups en-keyword=Morerafs theorem kn-keyword=Morerafs theorem END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=2 article-no= start-page=137 end-page=139 dt-received= dt-revised= dt-accepted= dt-pub-year=1972 dt-pub=197210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Another proof of the invariance of Ulm's functions in commutative modular group rings en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=DuboisPaul F. en-aut-sei=Dubois en-aut-mei=Paul F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SehgalSudarshan K. en-aut-sei=Sehgal en-aut-mei=Sudarshan K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=University of Alberta affil-num=2 en-affil= kn-affil=University of Alberta END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=1 article-no= start-page=137 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=198401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On nil and nilpotent derivations en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiranoYasuyuki en-aut-sei=Hirano en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamakawaHirofumi en-aut-sei=Yamakawa en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=1 article-no= start-page=126 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070918 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Convective Instability in a Microemulsion Phase-Change-Material Slurry Layer en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In the present experimental study, the stability of Rayleigh-Benard convection has been investigated in rectangular enclosures filled with microemulsion Phase-Change-Material (PCM) slurry. The PCM slurry exhibited a pseudoplastic non-Newtonian fluid behavior. Hysteresis in convection was clearly observed while the PCM were in a solid phase and in phase changing. The critical Rayleigh number decreases with the PCM mass concentration while the PCM is in phase changing. The fluid temperature at the center of the enclosure showed a time-dependent oscillation during the transition from a heat conduction state to a convection state. The maximum Nusselt number has been observed for all of the slurries while the heating plate was controlled at a temperature that most of PCM was in phase changing.

en-copyright= kn-copyright= en-aut-name=InabaHideo en-aut-sei=Inaba en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DaiChuanshan en-aut-sei=Dai en-aut-mei=Chuanshan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HoribeAkihiko en-aut-sei=Horibe en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Tianjin University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=Rayleigh-B?nard Convection kn-keyword=Rayleigh-B?nard Convection en-keyword=Microemulsion kn-keyword=Microemulsion en-keyword=Phase Change Material kn-keyword=Phase Change Material en-keyword=Convective Instability kn-keyword=Convective Instability en-keyword=Subcritical Convection kn-keyword=Subcritical Convection en-keyword=Hysteresis kn-keyword=Hysteresis END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=3 article-no= start-page=123 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200706 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Calpain-calcineurin signaling in the pathogenesis of calcium-dependent disorder. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Intracellular calcium is a powerful secondary messenger that affects a number of calcium sensors, including calpain, a Ca2+-dependent cysteine protease, and calcineurin, a Ca2+/calmodulin-dependent protein phosphatase. Maintenance of low basal levels of intracellular calcium allows for the tightly regulated physiological activation of these proteins, which is crucial to a wide variety of cellular processes, such as fertilization, proliferation, development, learning, and memory. Deregulation of calpain and calcineurin has been implicated in the pathogenesis of several disorders, including hypertension, heart disease, diabetes, cerebral ischemia, and Alzheimer's disease. Recent studies have demonstrated an interplay between calpain and calcineurin, in which calpain can directly regulate calcineurin activity through proteolysis in glutamate-stimulated neurons in culture and in vivo. The calpain-mediated proteolytic cleavage of calcineurin increases phosphatase activity, which promotes caspase-mediated neuronal cell death. Thus, the activation of the calpain-calcineurin pathway could contribute to calcium-dependent disorders, especially those associated with Alzheimer's disease and myocardial hypertrophy. Here, we focus briefly on recent advances in revealing the structural and functional properties of these 2 calcium-activated proteins, as well as on the interplay between the 2, in an effort to understand how calpain-calcineurin signaling may relate to the pathogenesis of calcium- dependent disorders. en-copyright= kn-copyright= en-aut-name=WuHai-Yan en-aut-sei=Wu en-aut-mei=Hai-Yan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TomizawaKazuhito en-aut-sei=Tomizawa en-aut-mei=Kazuhito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuiHideki en-aut-sei=Matsui en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=calpain kn-keyword=calpain en-keyword=calcineurin kn-keyword=calcineurin en-keyword=calcium kn-keyword=calcium en-keyword=proteolysis kn-keyword=proteolysis en-keyword=neurodegeneration kn-keyword=neurodegeneration END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=2 article-no= start-page=137 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=201004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Is There Any Association between TV Viewing and Obesity in Preschool Children in Japan? en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Obesity in children is a serious public health problem, and TV viewing is considered a potential risk factor. Since, however, no relevant association studies have been conducted in Japan, we evaluated the association between TV viewing and obesity using a population-based study conducted in a Japanese town. All 616 preschool children in the town were enrolled in February 2008, and a self-administered questionnaire to collect children's and parents' characteristics was sent to the parents. We dichotomized the time spent TV viewing and evaluated associations by logistic regression using a "less than 2h" category as a reference. The questionnaire was collected from 476 participants (77.3%), of whom 449 were available for the final analyses. Among them, 26.9% of preschool children reported 2 or more hours of TV viewing per day and 8.2% were defined as obese. In logistic regression analyses, there was no positive association in unadjusted (odds ratio [OR]1.11, 95% confidence interval [95% CI]:0.50-2.49) or adjusted models for exclusively breastfed status, sleep duration, or maternal factors (OR1.11, 95% CI:0.50-2.51). We also found no positive association between TV viewing and overweight status, possibly owing to the influence of social environment, low statistical power, or misclassification.

en-copyright= kn-copyright= en-aut-name=SasakiAyako en-aut-sei=Sasaki en-aut-mei=Ayako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwaseToshihide en-aut-sei=Iwase en-aut-mei=Toshihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KomatsuHirokazu en-aut-sei=Komatsu en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DoiHiroyuki en-aut-sei=Doi en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Community Care, Saku Central Hospital affil-num=5 en-affil= kn-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=TV viewing kn-keyword=TV viewing en-keyword=obesity kn-keyword=obesity en-keyword=preschool children kn-keyword=preschool children END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=3 article-no= start-page=137 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=196606 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Histochemical studies on the red, white and intermediate muscle fibers of some skeletal muscles. Ⅲ. Histochemical demonstration of oxidative enzymes, phosphorylase and glycogen in respiratory muscle fibers en-subtitle= kn-subtitle= en-abstract= kn-abstract=

1) Three different types of muscle fibers were clearly distinguished in the intercostal muscles and the diaphragm of human, cat and rat by histochemical demonstration of oxidative enzymes, phosphorylase and glycogen. 2) The intercostal muscles and diaphragm each presented dissimilar patterns of the muscle fibers. The diaphragm did not show any definite correlation between the diameter and the histochemical reaction of muscle fibers but its red fibers indicated a more intense uptake of Nitro-BT formazan deposits in the subsarcolemmal region. In this conection, the relationship between the motor innervation and histochemical evaluation of the diaphragm was described. 3) Phosphorylase and glycogen showed reciprocal reactions to the oxidative enzyme activity. They were generally high in large fibers but low in small fibers, and moderate in intermediate fibers.

en-copyright= kn-copyright= en-aut-name=NishiyamaAkira en-aut-sei=Nishiyama en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=2 article-no= start-page=125 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=197404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Selection and application of factors for forecasting the epidemic time and severity of Japanese encephalitis prevalence en-subtitle= kn-subtitle= en-abstract= kn-abstract=

For predicting median date or incidence rate in the prevalence of japanese encephalitis, the authors considered the 34 factors; namely, the climate, latitude, longitude, and date showing immunological positivity of hemoagglutination inhibiting reaction on 50% the number of swine, etc. To make the mean square residual the smallest which yields, in the case of calculating with the multiple regression equation, the most important and meritorious factors were selected from the factors mentioned above by the voluntary selection rule devised by us. Multiple regression equations were formulated for them. To predict the median date in the prevalence of japanese encephalitis in whole japan, we found that the three factors, i. e. the amount of rainfall in April, the average temperature in March and HI positive rate of swine till the end of july, were essential. And for the foreseeing of incidence rate in Okayama Prefecture, factors concerning mosquitoes were added; this resulted in the useful two factors, namely, common logarithm of the total number of Culex tritaeniorhynchus till july 20th and the rainfall in June.

en-copyright= kn-copyright= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OsakiHirokazu en-aut-sei=Osaki en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=22 cd-vols= no-issue=3 article-no= start-page=137 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=196806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Suppression of antibody formation by the res-blockade. Ⅲ. Effects of the res-blockade with methyl palmitate en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The rats which received the repeated intra peritoneal or intravenous　injections of methyl palmitate showed a marked depressed phagocytic activity　of the RES as shown by the clearance test with radioactive iron as　well as by histological observations and a significantly suppressed antibody　formation against the challenge by BSA.　Differing from the cases of the blockade of the RES made by PVP or　radiogold, the injection of methyl palmitate did not result in any injurious　effect on the lymph follicles of lymph nodes and spleen and the plasma　cells proliferation as revealed by the histological observation. Histochemical observations of iron phagocytosis of the RES done by　Perls stain revealed that methyl palmitate　suppressed the phagocytic activity　of the Kupffer cells of the liver dramatically and also suppressed the　phagocytic activity of the sinus-lining cells in spleen to a lesser degree.　The result indicates that the injection of methyl palmitate attacks the phagocytic　function of the RES selectively and induces the reduced immune　response of the organism without giving any damages to the proliferation of immunologically com petent cells.　The fact suggests that the RES lowered in their phagocytic activity　fails to produce the informational substance for immune　response, showing　a lower level in the antibody formation even in the presence of antigen　and proliferating immunologically competent cells.

en-copyright= kn-copyright= en-aut-name=OhbuchiShinji en-aut-sei=Ohbuchi en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=2 article-no= start-page=137 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=196904 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Zusammenfassung ?ber vasoto-nin in der theorie und praxis und seine anwendung bei ven?sen und arteriellen durchblutungsst?rungen en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Die Autoren berichten uber die guten Behandlungsmoglichkeiten in der Praxis bei verschiedenen peripheren venosen Durchblutungsstorungen bei Erkrankungen der Bewegungsapparate, bei leichteren Fallen von arteriellen DurchblutungsstOrungen und bei einigen Fallen von Hirnblutungen mit Vasotonin und Vasotonin-forte und auch in vitro-Blutgerinnungsuntersuchungen. Bei den erwahnten Fallen kann man die therapeutische Wirkung noch mit Vasotonin-forte-Salbe gut unterstutzen. Die Autoren konnen nachweisen, daB Extr. Arnicae insbesonder in dem Vasotonin-forte die hamodynamische und die blutgerinnungshemmende Wirkung von extr. Aesculi Hippercastani gut verstairkt.

en-copyright= kn-copyright= en-aut-name=SzirmaiEndre en-aut-sei=Szirmai en-aut-mei=Endre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SachsVolkmar en-aut-sei=Sachs en-aut-mei=Volkmar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Institut fur Kernenergetik der Universitat Stuttgart affil-num=2 en-affil= kn-affil=Institut fur Kernenergetik der Universitat Stuttgart END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue=3 article-no= start-page=127 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=196406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Iron metabolism of in?testinal mucosa in various blood diseases en-subtitle= kn-subtitle= en-abstract= kn-abstract=

For the investigation of iron metabolism in the intestinal mucosa in various　blood diseases, intestinal biopsy (duodenum) was performed on 10 healthy controls　and 35 cases with various blood diseases. The following are　the results　of the studies on distribution of stainable　iron, amounts of non-hemin iron in the　biopsied materials, and iron uptake of the intestinal epithelial cells.　1) An evaluation of distribution of stainable iron by Berlin　blue reaction　showed none or very mild degree, if any,　inhealthy controls, an increase in　aplastic anemia,　pernicious anemia, some of leukemias and in iron deficiency anemia following iron therapy, and a decrease in　idiopathic hypochromic anemia, anchylostomiasis anemia,　anemia with cancer, myxedema, hemolytic anemia,　and in　some of leukemias. Some of anemia with cancer, however,　showed an　increase of a certain degree. In iron absorption tests, no changes were found other than a very mild increase in aplastic anemia. 2) Non-hemin iron was 70-112γ/g in healthy controls, increased in aplastic anemia approximately to 100-200γ/g, ranging 40-130γ/g in leukemia, and decreased in idiopathic hypochromic anemia and in anemia with cancer ranging 30-60γ/g and 30-50γ/g respectively. Amounts of non-hemin iron and serum iron or sideroblasts show a fair correlation. The fractionation of nonhemin iron in aplastic anemia didn't show any difference in relationship of each fraction from healthy controls despite the increased amount in the former. 3) A radioautographic evaluation of iron uptake by intestinal epithelium was performed by our device for evaluation of intestinal absorption capacity. The iron uptake was mild in healthy controls, almost none in aplastic anemia, and marked in iron deficiency anemia where it was decreased approximately to the level of healthy controls following iron therapy. 4) The intestinal tissue iron showed a series of changes similar to those of iron present in the serum or erythroblasts, and the non-hemin iron in the intestinal mucosa is inversely correlated with iron uptake of epithelium and is considered to regulate the absorption according to its amount.

en-copyright= kn-copyright= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsuchidaJunichiro en-aut-sei=Tsuchida en-aut-mei=Junichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KodaniHidenari en-aut-sei=Kodani en-aut-mei=Hidenari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=3 article-no= start-page=137 end-page=175 dt-received= dt-revised= dt-accepted= dt-pub-year=1962 dt-pub=196206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Diagnosis of Gastric Cancer in Early Stage ? The Clinical Ob?servation of Operated Cases en-subtitle= kn-subtitle= en-abstract= kn-abstract=

1. An attempt has been made to find the diagnostic criteria for early gastric cancer. It is most important to detect the evidences or suspected features of the malignant growth in incipient stage in order to attain the radical cure by surgical operation. 2. Twelve patients with early gastric cancer (groups A and B) were selected out of 476 patients who had undergone gastrectomy during the past three years in the Okayama Saiseikai General Hospital. The other 6 patients in the "precancerous group" (group C) were also studied, who had abnormal epithelial proliferation in the resected stomach membrane during the same period. 3. The processes of discovery of early cancer have been described. Fairly precise diagnosis can be made in the mucosal carcinoma, but it is not in the ulcer-carcinoma. It was generally difficult to estimate the degree of the malignancy and the extension of the growth preoperatively. 4. The details of the diagnostic aids are as follows. i. Negative occult blood of stool does not always mean the definite diagnostic aid. ii. The malignant gastric change may occur even in non-anacidity. Further investigations should be followed up on gastric ulcer patients if malignant alteration is under the consideration. iii. Minor roentgenological findings, such as the absence or irregularity of mucosal folds, rigid and/or overlapped contour, localized absence or decrease of the peristaltic waves and absence or bow-shaped deformity of the angulus, are of important significance. Such changes should be minutely sought for by X-ray film examination. iv. On gastroscopy and gastrocamera photography, such changes as erosion or irregular granular thickening of the membrane with abnormal reddening and edematous appearance, irregularity of ulcer edge, uneven swelling on ulcer margin with reddening and unsharpness of the edge of adherent coat on ulcer floor, must be noted in the early gastric cancer. v. It is not safe to leave a patient having stomach ulceration under a mere conservative management because it is often quite difficult to dissolve the question of malignancy of the lesion with all sorts of examinations. vi. So far as clinical examinations have indicated malignancy, histological examination must be carried out immediately at the time of operation, even when malignant lesion is absent in inspection and palpation on the exposure of the stomach. vii. On the gross observation of the resected stomach, a particular attention must be paid to erosion, depression or atrophy, irregular granular thickening and abnormal reddening on the restricted areas of the mucosal surface.

en-copyright= kn-copyright= en-aut-name=ManoKiyoshi en-aut-sei=Mano en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HitomiYasushi en-aut-sei=Hitomi en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KaraiAkira en-aut-sei=Karai en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YabeYasuhiro en-aut-sei=Yabe en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KataokaKazuo en-aut-sei=Kataoka en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OnodaOsamu en-aut-sei=Onoda en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IkegamiIchiro en-aut-sei=Ikegami en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaekawaSeigen en-aut-sei=Maekawa en-aut-mei=Seigen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamaguchiMichiya en-aut-sei=Yamaguchi en-aut-mei=Michiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KatoNobuhiro en-aut-sei=Kato en-aut-mei=Nobuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HiroseShuhei en-aut-sei=Hirose en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YuharaAtsuyoshi en-aut-sei=Yuhara en-aut-mei=Atsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=ImaiMasanobu en-aut-sei=Imai en-aut-mei=Masanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KitaShooichi en-aut-sei=Kita en-aut-mei=Shooichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=NobutoHideo en-aut-sei=Nobuto en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=2 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=3 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=4 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=5 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=6 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=7 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=8 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=9 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=10 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=11 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=12 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=13 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=14 en-affil= kn-affil=Okayama Saiseikai General Hospital affil-num=15 en-affil= kn-affil=Okayama Saiseikai General Hospital END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=3 article-no= start-page=137 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=200006 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High prevalence of hepatitis C in patients with thalassemia and patients with liver diseases in Myanmar (Burma). en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We conducted Myanmar-Japan cooperation studies on hepatitis B and hepatitis C virus markers in patients with thalassemias and those with liver diseases. Among the 102 patients with liver diseases, 92% had a history of hepatitis B virus infection (antibody to hepatitis B core antigen positive), 35% were hepatitis B surface antigen positive, 39% were positive for anti-HCV. Among 28 patients with hepatocellular carcinoma, 46% had hepatitis B surface antigen, 21.4% had antibody to hepatitis C virus, and 7% were positive for both hepatitis B surface antigen and anti hepatitis C virus. The history of HCV infection among blood recipients at the Haematology Department of the Yangon General Hospital and at the Yangon Children's Hospital was found to be 55.5% and 46.7%, respectively, which is comparable to the history of hepatitis B infection (66.7% and 46.7%, respectively). This preliminary survey also encountered 2 cases positive for anti-HCV among 34 voluntary blood donors. This survey is the first one to report that hepatitis C is at the epidemic stage in Myanmar. As there is no effective treatment for hepatitis C in this country, a screening program for blood used in transfusion should be started immediately.

en-copyright= kn-copyright= en-aut-name=OkadaShigeru en-aut-sei=Okada en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaketaKazuhisa en-aut-sei=Taketa en-aut-mei=Kazuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IshikawaTakatoshi en-aut-sei=Ishikawa en-aut-mei=Takatoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KojiTakehiko en-aut-sei=Koji en-aut-mei=Takehiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SweThan en-aut-sei=Swe en-aut-mei=Than kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WinNe en-aut-sei=Win en-aut-mei=Ne kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WinKhin Maung en-aut-sei=Win en-aut-mei=Khin Maung kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MraRai en-aut-sei=Mra en-aut-mei=Rai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MyintThein Thein en-aut-sei=Myint en-aut-mei=Thein Thein kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=University of Tokyo affil-num=4 en-affil= kn-affil=Nagasaki University affil-num=5 en-affil= kn-affil=Yangon General Hospital affil-num=6 en-affil= kn-affil=Yangon General Hospital affil-num=7 en-affil= kn-affil=Yangon General Hospital affil-num=8 en-affil= kn-affil=Yangon General Hospital affil-num=9 en-affil= kn-affil=Yangon Children Hospital en-keyword=hepatitis C kn-keyword=hepatitis C en-keyword= Myanmar (Burma) kn-keyword= Myanmar (Burma) en-keyword=thalassemia kn-keyword=thalassemia en-keyword=hepatitis B kn-keyword=hepatitis B END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=2 article-no= start-page=137 end-page=140 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197904 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Syncytia formation of human transformed cell lines by simian sarcoma virus type I (SSV-I/SSAV-I). en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Human cells derived from malignant tumors (HeLa, HEp-2 and KB) and human cells transformed by tumor viruses (KCand RSb) formed syncytia by simian sarcoma virus type I (SSV-I/SSAV-I), but human diploid or non-transformed cells (WI-38, HEL and HEC) did not.

en-copyright= kn-copyright= en-aut-name=OchoMunehiko en-aut-sei=Ocho en-aut-mei=Munehiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OguraHajime en-aut-sei=Ogura en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaTerukazu en-aut-sei=Tanaka en-aut-mei=Terukazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OdaTakuzo en-aut-sei=Oda en-aut-mei=Takuzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University en-keyword=simian sarcoma virus kn-keyword=simian sarcoma virus en-keyword=syncytia formation kn-keyword=syncytia formation en-keyword=cell fusion kn-keyword=cell fusion en-keyword=human transformed cell lines kn-keyword=human transformed cell lines en-keyword=human cell strains kn-keyword=human cell strains END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=3 article-no= start-page=137 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Infusion of Hypertonic Saline into the Lung Parenchyma during Radiofrequency Ablation of the Lungs with Multitined Expandable Electrodes:Results Using a Porcine Model en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The present study was performed to clarify the effect of hypertonic saline infusion into the lung parenchyma on radiofrequency ablation (RFA) of the lungs. A total of 20 ablation zones were created in 3 pigs. The ablation zones were divided into 3 groups. Group 1 (n6) consisted of ablation zones created by applying smaller radiofrequency (RF) power without saline infusion;group 2 (n5) zones were created by applying greater RF power without saline infusion;and group 3 (n9) zones were created by applying greater RF power with saline infusion. The techniques of saline infusion included administration of hypertonic saline 1ml before RFA, followed by continuous administration at a rate of 1ml/min during the first 2min after the initiation of RFA. The ablation parameters and coagulation necrosis volumes were compared among the groups. Group 3 had a tendency toward smaller mean impedance than group 1 (p0.059) and group 2 (p0.053). Group 3 showed significantly longer RF application time than group 2 (p0.004) and significantly greater maximum RF power than group 1 (p0.001) and group 2 (p0.004). Group 3 showed significantly larger coagulation necrosis volume (mean, 1,421mm3) than group 2 (mean, 858mm3, p0.039) and had a tendency toward larger necrosis volume than group 1 (mean, 878mm3, p0.077). Although this small study had limited statistical power, hypertonic saline infusion during RFA appeared to enlarge coagulation necrosis of the lung parenchyma.

en-copyright= kn-copyright= en-aut-name=IishiTatsuhiko en-aut-sei=Iishi en-aut-mei=Tatsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MimuraHidefumi en-aut-sei=Mimura en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GobaraHideo en-aut-sei=Gobara en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KuroseTaichi en-aut-sei=Kurose en-aut-mei=Taichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujiwaraHiroyasu en-aut-sei=Fujiwara en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SakuraiJun en-aut-sei=Sakurai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YanaiHiroyuki en-aut-sei=Yanai en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=radiofrequency ablation kn-keyword=radiofrequency ablation en-keyword=lung kn-keyword=lung en-keyword=experimental study kn-keyword=experimental study END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=2 article-no= start-page=133 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=194303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Veranderungen der Zellen im subkutanen Bindegewebe der Maus bei der Injektion von Arzneimitteln. : IV. Injektion von Sulfonamidpaparaten. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Die ortliche Reizung durch die subkutan injizierten sulfonamid-praparate ist uberhaupt viel schwacher als diejenigen der Vaccine. Ihre Wirkung ist vor allem durch eine Vermehrung der Histiozyten im Subkutangewebe nicht nur am Injektionsort, sondern auch an der anderen Korperseite charakterisiert. Die Histiozyten entstehen hauptsachlich aus den ortsansassigen Fibrozyten. Es steht aber noch dahin, inwieweit die so vermehrten Histiozyten zur Heilung der Streptokokkensepsis u. a. beitragen konnen.

en-copyright= kn-copyright= en-aut-name=MiiYosiaki en-aut-sei=Mii en-aut-mei=Yosiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=2 article-no= start-page=135 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Occlusion of a postoperative rectoabdominocutaneous fistula with fibrin clot: a case report. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A 56 year-old rectal cancer patient who developed a chronic rectoabdominocutaneous fistula postoperatively was treated with fibrin clot, and the fistula healed completely. Occlusion of chronic postoperative fistulas with fibrin clot appears to be a useful technique.

en-copyright= kn-copyright= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NezuMasashi en-aut-sei=Nezu en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NonakaYasuyuki en-aut-sei=Nonaka en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KimuraToshikazu en-aut-sei=Kimura en-aut-mei=Toshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MarutakaMasahito en-aut-sei=Marutaka en-aut-mei=Masahito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KurodaMuneaki en-aut-sei=Kuroda en-aut-mei=Muneaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama Univeristy affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University en-keyword=enterocutaneous fistula kn-keyword=enterocutaneous fistula en-keyword=fibrin clot kn-keyword=fibrin clot END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=3 article-no= start-page=131 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Experimental study of partial liquid ventilation in the setting of acute respiratory failure induced by sea water lung lavage in rabbits. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

To study the effect of partial liquid ventilation (PLV) with perfluorocarbon on acute respiratory failure, 3 groups of 17 rabbits were examined to compare. After acute respiratory failure was induced by lung lavage with sea water in 12 of the 17 rabbits, 7 of the 12 rabbits were treated with conventional mechanical ventilation (AC group) and 5 of the 12 rabbits were treated with PLV using perfluorocarbon (AP group). The remaining 5 normal rabbits without acute respiratory failure were treated with PLV with perfluorocarbon as a control group (PL group). In the PL group, PaO2, PaCO2, blood pH, pulmonary compliance or pathological findings were not so changed after PLV. In the AC and AP groups, PaCO2 significantly increased, and in contrast, PaO2 and pulmonary compliance significantly decreased after lung lavage. However, these findings improved to almost the same levels as those of a control group within 2 h after the PLV treatment in the AP group, but in the AC group, these gradually deteriorated over time. As for the pathological findings, pulmonary vascular congestion, alveolar hemorrhage and inflammatory infiltration were observed in the AC group. However, these findings were not observed in the specimens of the AP group. From these results, PLV with perfluorocarbon was shown to be useful to improve gas exchange and pulmonary functions without major side effects.

en-copyright= kn-copyright= en-aut-name=SawadaShigeki en-aut-sei=Sawada en-aut-mei=Shigeki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IchibaShingo en-aut-sei=Ichiba en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ItanoHideki en-aut-sei=Itano en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShogaKazuhiko en-aut-sei=Shoga en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShimizuNobuyoshi en-aut-sei=Shimizu en-aut-mei=Nobuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=liquid ventitation kn-keyword=liquid ventitation en-keyword=perfluorocarbon kn-keyword=perfluorocarbon en-keyword=acute respiratory failure kn-keyword=acute respiratory failure en-keyword=lung lavage kn-keyword=lung lavage en-keyword=sea water kn-keyword=sea water END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=2 article-no= start-page=137 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=198104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Abnormalities of chromosome no. 1 related to blood dyscrasias: study of 10 cases. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Partial excess of chromosome 1 (q25-q32) was noted in malignant cells from all of 10 patients who had disorders such as non-African Burkitt's lymphoma, adult T-cell leukemia, myelofibrosis, malignant lymphoma, chronic lymphocytic leukemia or chronic myelocytic leukemia in blast crisis. The break points on chromosome 1 were at centromere, q12, q21, q23, q25 and q32. Variations in the specific region of the long arm of chromosome 1, q25-q32, were thought to be important in the evolution of malignant cell proliferation.

en-copyright= kn-copyright= en-aut-name=MiyamotoKanji en-aut-sei=Miyamoto en-aut-mei=Kanji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HamasakiKazuhide en-aut-sei=Hamasaki en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AdachiTomiro en-aut-sei=Adachi en-aut-mei=Tomiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaToshio en-aut-sei=Tanaka en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SatoJiro en-aut-sei=Sato en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University en-keyword=chromosome no. 1 kn-keyword=chromosome no. 1 en-keyword=malignant lympoma kn-keyword=malignant lympoma en-keyword=leukemia kn-keyword=leukemia en-keyword= chromosome aberration. kn-keyword= chromosome aberration. END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=2 article-no= start-page=137 end-page=168 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Some clinical aspects of rheumatoid arthritis en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In our department we have been placing a special emphasis on the treatment and study of rheumatoid arthritis, and during the last four years we have handled about 1,600 cases visiting our outpatient clinic and approximately 100 hospitalized cases. Our experiences with these patients are only what might be called an introductory phase in the study and treatment of rheumatoid arthritis when compared with those in Europe and America. In estimating the incidence of rheumatoid arthritis in Japan from various available data, although it would not reach the level of England and U.S.A., it will be about 100 cases per 100,000 population, matching more or less the incidence in the northern Europe. As regards sex and the predisposing age we find no great difference from those in Europe and America. One striking difference that we find is the fact that patients in our country have very little resistance against salicylic acid drug used in treatment. Therefore, it is unreasonable to expect a good anti-inflammatory action by administering a large dosage of 5-10g of such a drug as aspirin per day. It must be limited within a comparatively small dosage of 1.0 to 2.0 g or with concomitant administration of prednisolone and aspirin in the hope of utilizing its analgesic effect. Furthermore, it is not feasible to introduce the results of studies made in Europe and America on the salicylic drug and its prescription all of them showing the concentration in blood 35 mg%, which is on the borderline of intoxicating dosage. This is only one example, and with some more experiences we shall undoubtedly encounter many dissimilar points. Therefore, it is essential that rheumatology specific to Japan needs to be established.

en-copyright= kn-copyright= en-aut-name=KodamaToshio en-aut-sei=Kodama en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue=3 article-no= start-page=137 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Changes in Plasma Concentrations of Vitronectin in Patients with Diabetic Nephropathy en-subtitle= kn-subtitle= en-abstract= kn-abstract=

To investigate the role of vitronectin in the progression of diabetic nephropathy, plasma concentrations of vitronectin were measured by enzyme-linked immunosorbent assay in patients with diabetes mellitus and compared with normal control subjects. In diabetic patients with normoalbuminuria and microalbuminuria, plasma concentrations of vitronectin were significantly higher than those of control subjects. Plasma concentrations of vitronectin in diabetic patients with chronic renal failure were significantly lower than those with normal renal function. There was a significant positive correlation between plasma concentration of vitronectin and blood platelet counts. In the early stage of diabetic nephropathy, vitronectin may be increased caused by synthesis from activated platelets. With progression of diabetic nephropathy, plasma vitronectin may be decreased because of accumulation in sclerotic glomeruli and arteriosclerotic lesions. In conclusion, the plasma concentration of vitronectin appears to be an important marker for the progression of diabetic nephropathy.

en-copyright= kn-copyright= en-aut-name=MoriokaShigeru en-aut-sei=Morioka en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama University en-keyword=vitronectin(S-protein) kn-keyword=vitronectin(S-protein) en-keyword=diabetic nephropathy kn-keyword=diabetic nephropathy en-keyword=hypertension kn-keyword=hypertension en-keyword=chronic renal failure kn-keyword=chronic renal failure en-keyword=enzyme-linked immunosorbent assay (ELISA) kn-keyword=enzyme-linked immunosorbent assay (ELISA) END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=2 article-no= start-page=119 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=197806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Studies on N, N'-dimethylnitrosourea-induced brain tumors in rats--especially, on microtumors. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The incidences, distribution and histopathological findings of N, N'-dimethylnitrosourea (DMNU)-induced brain microtumors in Sprague-Dawley rats were studied. Subcutaneous injections of DMNU in young adult rats one a week resulted in the induction of 122 gliomas in 38 animals with an incidence of 69% after a time lapse of between 157 and 246 days from the first injection. Of these tumors, 66 were classified as microtumors (diameter less than about 1 mm) by detailed light microscopy observation of serial sections. The microtumors were of 3 types: 55 oligodendrogliomas, 8 astrocytomas and 3 mixed gliomas. As the tumors became larger in size, anaplasia appeared, especially in the central part of the tumors. The microtumors developed randomly throughout the brain. It was concluded that, in adult rat brains, the target cells of DMNU were well differentiated glial cells which had already migrated from the matrix layer.

en-copyright= kn-copyright= en-aut-name=JinnaiHitoshi en-aut-sei=Jinnai en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=dimethylnitrosourea kn-keyword=dimethylnitrosourea en-keyword=rat kn-keyword=rat en-keyword=brain kn-keyword=brain en-keyword=microtumor kn-keyword=microtumor en-keyword=glioma kn-keyword=glioma END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=3 article-no= start-page=137 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198806 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Defective killer cell activity in patients with chronic active Epstein-Barr virus infection. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Natural killer (NK) cell activity, lymphokine activated killer (LAK) activity and Epstein-Barr virus specific cytotoxic T lymphocyte (EBV-CTL) activity were examined in 10 children with chronic active EB-virus infection and an adult with persistently positive early antigen-antibody to EB-virus. NK cell activity against erythroleukemia cell line K-562 was significantly (p less than 0.005) lower in the patients (22.3 +/- 8.5%, mean +/- SD) than in normal controls (40.4 +/- 15.9%). Spontaneous cytotoxicity against an EB-virus transformed autologous lymphoblastoid cell line was 15.0 +/- 7.6% in the patients, and was comparable to spontaneous cytotoxicity activity in normal controls (11.7 +/- 4.3%). LAK activity against Raji cells was significantly (p less than 0.02) lower in the patients (14.6 +/- 11.4%) than in normal controls (29.2 +/- 15.9%). EBV-CTL activity against an EB-virus transformed autologous lymphoblastoid cell line was significantly (p less than 0.005) lower in the patients (11.8 +/- 5.5%) than in seropositive normal controls (33.7 +/- 14.7%). No regression of the lymphoblastoid cell line was observed when EBV-CTL activity of the patients was tested by regression assay. It is conceivable that defects in both EB-virus specific and nonspecific killer cell activities play important roles in the pathogenetic abnormalities which allow EB-virus infection to progress to a chronic active state.

en-copyright= kn-copyright= en-aut-name=WakiguchiHiroshi en-aut-sei=Wakiguchi en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiedaMikiya en-aut-sei=Fujieda en-aut-mei=Mikiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsumotoKenji en-aut-sei=Matsumoto en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OharaYuji en-aut-sei=Ohara en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WakiguchiAkiko en-aut-sei=Wakiguchi en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KurashigeTakanobu en-aut-sei=Kurashige en-aut-mei=Takanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Kochi Medical School affil-num=2 en-affil= kn-affil=Kochi Medical School affil-num=3 en-affil= kn-affil=Kochi Medical School affil-num=4 en-affil= kn-affil=Kochi Medical School affil-num=5 en-affil= kn-affil=Kochi Medical School affil-num=6 en-affil= kn-affil=Kochi Medical School en-keyword=chronic active EB-virus infection kn-keyword=chronic active EB-virus infection en-keyword=EB-virus specific cytotoxic T lymphocyte kn-keyword=EB-virus specific cytotoxic T lymphocyte en-keyword=natural killer kn-keyword=natural killer en-keyword=lymphokine activated killer kn-keyword=lymphokine activated killer END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=3 article-no= start-page=131 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199606 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Purification and characterization of a 39kDa apurinic/apyrimidinic endonuclease from mouse ascites sarcoma cells. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

<P>We purified an apurinic/apyrimidinic (AP) endonuclease from mouse ascites sarcoma (SR-C3H/He) cells. The enzyme showed nicking activity on acid-depurinated DNA but not on untreated, intact DNA. It also showed priming activity for DNA polymerase on both acid-depurinated and bleomycin-damaged DNA. The priming activity on bleomycin-damaged DNA was two times higher than that on an acid-depurinated DNA. The enzymatic properties indicate that the enzyme is a class II AP endonuclease having DNA 3' repair diesterase activity. The purified enzyme has a molecular weight of 39,000 as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The optimal pH for AP endonuclease activity was 8.0 in 50 mM Tris-HCl buffer. The AP endonuclease activity depended on divalent cation such as Mg2+ and Co2+ ions, and was inhibited by 2 mM EDTA with no addition of the divalent cation. An appropriate concentration of sodium or potassium salt stimulated the activity. Partial digestion of the AP endonuclease with Staphylococcus aureus V8 protease produced 4 major peptide fragments which may be used for protein sequencing.</P>

en-copyright= kn-copyright= en-aut-name=WakabayashiHajime en-aut-sei=Wakabayashi en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SekiShuji en-aut-sei=Seki en-aut-mei=Shuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy en-keyword=AP endonuclease kn-keyword=AP endonuclease en-keyword=DNA 3' repair diesterase kn-keyword=DNA 3' repair diesterase en-keyword=DNA repair enzyme kn-keyword=DNA repair enzyme en-keyword=mouse ascites sarcoma cells kn-keyword=mouse ascites sarcoma cells END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=3 article-no= start-page=137 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199506 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Virological and serological characterization of asymptomatic blood donors positive for anti-hepatitis C virus antibody. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

To study the virological and serological characteristics of asymptomatic hepatitis C virus (HCV) carriers, 165 blood donors positive for antibody against HCV proteins by the second generation assay, were analyzed for their clinical backgrounds, serological reactivity against antigens derived from HCV by recombinant immunoblot assay, and the amount and genotype of HCV by the polymerase chain reaction. Compared with blood donors having abnormal levels of alanine aminotransferase (ALT), sera from the donors with normal levels of ALT reacted less frequently against NS4 antigens (anti-5-1-1: 34.4% vs. 54.5%, P = 0.0609; anti-c100-3: 34.4% vs. 56.1%, P < 0.05). Also the positivity for antibodies against these antigens were more frequent in sera from donors with genotype 1b HCV-RNA than other genotypes (anti-5-1-1: 61.0% vs. 23.5%, P < 0.01; anti-c 100-3: 61.0% vs. 26.5%, P < 0.01). The prevalence of each genotype in blood donors with normal ALT levels was different from that in patients with advanced liver disease (P < 0.05), genotype 1b being less and genotype 2a being more frequent. The number of HCV-RNA copies/0.5 ml in donors with normal ALT was 10(7.9 +/- 1.0) (n = 27) and that in patients with chronic liver disease was 10(7.4 +/- 0.8) (n = 116), the difference being statistically significant (P < 0.05). In conclusion, the results of this study suggest that asymptomatic blood donors carrying HCV have the serological and virological characteristics different from the patients with advanced liver disease.

en-copyright= kn-copyright= en-aut-name=TsujiHideyuki en-aut-sei=Tsuji en-aut-mei=Hideyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimomuraHiroyuki en-aut-sei=Shimomura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatoMasaki en-aut-sei=Wato en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KondoJunichi en-aut-sei=Kondo en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=hepatitis C virus kn-keyword=hepatitis C virus en-keyword=blood donor kn-keyword=blood donor en-keyword=asymptomatic carrier kn-keyword=asymptomatic carrier END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19975 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=3-D eddy current analysis in moving conductors of permanent magnet type retarders using moving coordinate system en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A 3-D DC steady state eddy current analysis of a permanent magnet type retarder which rotates at high speed is carried out using a moving coordinate system. The method of DC steady state analysis using a moving coordinate system is described. The calculated results, braking torque etc., are compared with measured ones

en-copyright= kn-copyright= en-aut-name=MuramatsuKazuhiro en-aut-sei=Muramatsu en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiNorio en-aut-sei=Takahashi en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HashinoTomohiro en-aut-sei=Hashino en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaChuji en-aut-sei=Yamada en-aut-mei=Chuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KobayashiSusumu en-aut-sei=Kobayashi en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KuwaharaTohru en-aut-sei=Kuwahara en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Isuzu Advanced Engineering Center, Limited affil-num=5 en-affil= kn-affil=Isuzu Advanced Engineering Center, Limited affil-num=6 en-affil= kn-affil=Isuzu Motors, Limited en-keyword=braking kn-keyword=braking en-keyword=eddy currents kn-keyword=eddy currents en-keyword=machine theory kn-keyword=machine theory en-keyword=permanent magnet machines kn-keyword=permanent magnet machines en-keyword=torque kn-keyword=torque END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=132 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20037 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A three-dimensional visualization of communications in distributed program environments en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In order to understand the behaviour of distributed program environments, we describe a three-dimensional visualization of communications. Most previous visualizations presented communications by means of the two dimensions of time and process, however, three dimensions are required to represent a message intermediary with visualization functions. We make use of a semantic configuration of messages, which is constructed by the quantities for three parametric factors: (i) time sequence, (ii) identifications of processors, and (iii) message exchanges.

en-copyright= kn-copyright= en-aut-name=SasakuraMariko en-aut-sei=Sasakura en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamasakiSusumu en-aut-sei=Yamasaki en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University en-keyword=distributed programming kn-keyword=distributed programming en-keyword=logic programming kn-keyword=logic programming en-keyword=message passing kn-keyword=message passing en-keyword=program visualisation kn-keyword=program visualisation END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=39 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinicopathological study of distal bile duct carcinoma at Fukuyama Medical Center kn-title=“–‰@‚É‚¨‚¯‚鉺•”’_ŠÇŠàŽèpÇ—á‚ÌŽ¡—Ã¬Ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced 20 patients with distal bile duct carcinoma from May, 1997 to December, 2007. The male/female ratio was 11/9 and the average age was 69.6 years. The operative procedures were as follows : pancreaticoduodenectomy (PD), 9 ; pyrolus preserving pancreaticoduodenectomy (PPPD), 8 ; subtotal stomach preserving pancreaticoduodenectomy (SSPPD), 2 and hepatico-jejunostomy without resection, 1. We performed a clinicopathological study on 16 patients with distal bile duct carcinoma, excluding 3 operation-related deaths and 1 unresectable case. The cumulative survival rate was 70% at 3 years and 11% at 5 years. The 3-year survival rates at fStageII, fStageIVa and fStageIVb were 100%, 80% and 0%, respectively. Log-rank analysis revealed that pathological pancreatic and duodenal invasion and curative resectability may be prognostic factors, while lymph node metastasis and perineural and stump invasion did not affect prognosis. Six recurrences in the 11 curative resection cases (54.5%) were observed ; therefore, postoperative systemic chemotherapy is warranted to curtail recurrence in advanced distal bile duct carcinoma. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=à_–ì—º•ã kn-aut-sei=à_–ì kn-aut-mei=—º•ã aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=ˆîŠ_—D kn-aut-sei=ˆîŠ_ kn-aut-mei=—D aut-affil-num=2 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=¼]Šw kn-aut-sei=¼] kn-aut-mei=Šw aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=“¿‰i®”V kn-aut-sei=“¿‰i kn-aut-mei=®”V aut-affil-num=4 ORCID= en-aut-name=TsunemitsuYosuke en-aut-sei=Tsunemitsu en-aut-mei=Yosuke kn-aut-name=íŒõ—m•ã kn-aut-sei=íŒõ kn-aut-mei=—m•ã aut-affil-num=5 ORCID= en-aut-name=OhtsukaShinya en-aut-sei=Ohtsuka en-aut-mei=Shinya kn-aut-name=‘å’ËáÁÆ kn-aut-sei=‘å’Ë kn-aut-mei=áÁÆ aut-affil-num=6 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=Šâì˜aG kn-aut-sei=Šâì kn-aut-mei=˜aG aut-affil-num=7 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=ŠâŠ_”Ž–¤ kn-aut-sei=ŠâŠ_ kn-aut-mei=”Ž–¤ aut-affil-num=8 ORCID= en-aut-name=SonobeHiroshi en-aut-sei=Sonobe en-aut-mei=Hiroshi kn-aut-name=‰€•”G kn-aut-sei=‰€•” kn-aut-mei=G aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=2 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=3 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=4 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=5 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=6 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=7 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=8 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=9 en-affil= kn-affil=’†‘’†‰›•a‰@@—Õ°ŒŸ¸‰È en-keyword=‰º•”’_ŠÇŠà (distal bile duct carcinoma) kn-keyword=‰º•”’_ŠÇŠà (distal bile duct carcinoma) en-keyword=Žèp (operation) kn-keyword=Žèp (operation) en-keyword=—\Œã‹K’èˆöŽq (independent prognostic factors) kn-keyword=—\Œã‹K’èˆöŽq (independent prognostic factors) END start-ver=1.4 cd-journal=joma no-vol=2009 cd-vols= no-issue=1 article-no= start-page=137 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20091112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Agent-based Simulation Analysis for Network Formation en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this paper, we conduct agent-based simulation experiments for network formation analysis. In the published papers, Bala and Goyal (2000) have constructed a mathematical model leading a star network to be strict Nash equilibrium. However, Berninghaus et al. (2007) have conducted the laboratory experiments using human subjects basing on the mathematical model, and the result of the experiments indicates that human subjects do not always make decision just as the mathematical model predicted. In this paper, we propose a simulation model using the adaptive artificial agents to clarify the reason of the deviation from the mathematical predictions. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=KambaraRika kn-aut-sei=Kambara kn-aut-mei=Rika aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=HayashidaTomohiro kn-aut-sei=Hayashida kn-aut-mei=Tomohiro aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=NishizakiIchiro kn-aut-sei=Nishizaki kn-aut-mei=Ichiro aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=KatagiriHideki kn-aut-sei=Katagiri kn-aut-mei=Hideki aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Hiroshima University affil-num=2 en-affil= kn-affil=Hiroshima University affil-num=3 en-affil= kn-affil=Hiroshima University affil-num=4 en-affil= kn-affil=Hiroshima University END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=9 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Screening test for chromosome aberrations of long-time residents in misasa spa. kn-title=ŽO’©‰·ò’n’·Šú“ü—ŽÒ‚Ì––½ŒŒõF‘Ì‚É‚¨‚æ‚Ú‚·‰e‹¿ en-subtitle= kn-subtitle= en-abstract=Screening test for chromosome aberrations of 13 long time residents, 9 native and 4 movingin in Misasa Spa was performed. Each Radon content in baths ranges 166-224 Bq/l, in homes 8.6-73.7 Bq/l, and in offices 8.4-22 Bq/l. Normal Karyotypes on both sexes and normal range of aberrations, gaps and breaks, were found in chromosome analyses. There are no significant radioactive effects from longtime bathings and from environment in both groups of Misasa spa districts, corresponding to the facts of no significant incidence of infertility, malformations, a brief span of life, and neoplasms compared to other places. kn-abstract=ŽO’©‰·ò‚̃‰ƒhƒ“ŠÜ—L‚ÍCŒ¹ò‚Å–ñ1347`2694Bq^lCí—p‰·ò…‚Å137`224Bq^lC‚Ü‚½C‰®“à‚Å‚Í7.3`73.7Bq^l‚Å‚ ‚éBŽO’©‰·ò’n‚Éo¶‚µ‚ÄC28`75”N‚ɂ킽‚é“ü—ŽÒ9–¼C‚¨‚æ‚ÑŽO’©‰·ò’nŠO‚Éo¶‚µ‚Ä16`78 ”N‚ɂ킽‚é“ü—ŽÒ4–¼‚ɂ‚¢‚Ä––½Ã–¬ŒŒ‚ÌõF‘ÌŒŸ¸‚ðCƒMƒ€ƒUõFC‚¨‚æ‚Ñ“Á‚É’·”N“ü—‚µ‚Ä‚¢‚é3–¼‚ɂ‚¢‚Ä‚ÍGˆê•ªõ–@‚É‚æ‚镪͂ðs‚È‚Á‚½B—…C‚¨‚æ‚ѶŠˆŠÂ‹«‚̃‰ƒhƒ“”Z“x‚Ì‘½‰Ç‚É‚æ‚炸C’·”N‚Ì“ü—‚É‚æ‚Á‚Ä‚àõF‘Ì‚Ì\‘¢•Ï‰»‚ͳí”͈͓à‚Å‚ ‚Á‚½B en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=ŒÃŒ³‰Ãº kn-aut-sei=ŒÃŒ³ kn-aut-mei=‰Ãº aut-affil-num=1 ORCID= en-aut-name=KohmotoTomoji en-aut-sei=Kohmoto en-aut-mei=Tomoji kn-aut-name=‰Í–{’m“ñ kn-aut-sei=‰Í–{ kn-aut-mei=’m“ñ aut-affil-num=2 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=»ì–ž kn-aut-sei=»ì kn-aut-mei=–ž aut-affil-num=3 ORCID= en-aut-name=YagiNobuko en-aut-sei=Yagi en-aut-mei=Nobuko kn-aut-name=–î–ØMŽq kn-aut-sei=–î–Ø kn-aut-mei=MŽq aut-affil-num=4 ORCID= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=Œä‘D­–¾ kn-aut-sei=Œä‘D kn-aut-mei=­–¾ aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®ŠÂ‹«•a‘ÔŒ¤‹†Ž{Ý affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®ŠÂ‹«•a‘ÔŒ¤‹†Ž{Ý affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®ŠÂ‹«•a‘ÔŒ¤‹†Ž{Ý affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®ŠÂ‹«•a‘ÔŒ¤‹†Ž{Ý affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@’†‰›ŒŸ¸•” en-keyword=ŽO’©‰·ò’n (Misasa spa) kn-keyword=ŽO’©‰·ò’n (Misasa spa) en-keyword=ƒ‰ƒhƒ“ò (Radon bath) kn-keyword=ƒ‰ƒhƒ“ò (Radon bath) en-keyword=õF‘̈Ùí (Chromosome aberration) kn-keyword=õF‘̈Ùí (Chromosome aberration) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=5-2 article-no= start-page=2509 end-page=2523 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590425 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Studies on Presbycusis Part ‡T: Relationship between the hearing in old age and the results of examinations of systemic functions Part ‡U Relationship between results of automatic audiometry and those of systemic examinaminations Part ‡V Relationship between the hearing in old age and electroencephalogram kn-title=˜Vl«“ï’®‚Ì—Õ° Œã•Ò ‘æ1•” ˜Vl‚ɉ—‚¯‚鎩‹LƒI[ƒaƒIƒ[ƒ^[ŒŸ¸¬Ñ‚Æ‘Sg”ŒŸ¸¬Ñ‚Æ‚ÌŠÖŒW‚ÉA‚¢‚Ä ‘æ2•” ˜Vl‚Ì’®—Í‚Æ”]”g‚Æ‚ÌŠÖŒW‚ÉA‚¢‚Ä ‘æ3•” ‘S•Ò‚Ì‘Š‡•À‚ÉŒ‹˜_ en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of carrying on studies on presbycusis from clinical standpoint the author conducted precise examinations of 137 cases over 40 years old visiting the Okayama National Hospital by conducting various systemic examinations, audiometry, electroencephalogram and automatic audiometry in some. In the pilot study, by classifying the hearing-loss into five new steps and by pursuing the relationship between the hearing in old age and various functions of different organs, the author odtained the following results. 1. The majority of hearing-loss show high tone-loss, and in the age range of forty and fifty years the disorders are more frequeutly of a mild degree, showing no marked difference in the two groups. However, in the age over 60 years these disorders increase in intensity and iu the age over 70 years this tends to become quite marked. 2. The aortensclerosis (as revealed by roentgenograms), urine protein content, and arteriosclerosis of retina are more frequently pathological along with the progress of hearing-loss clinicaly suggesting the relationship between the hearing disorders in old age and arteriosclerosis. 3. No relationship can be recognized between the hearing-loss and snch findings as the systemic blood pressures, blood pressure of fundus, the ratio detween the systemic blood pressure and that of fundus, cold pressure test, renal function, urine sugar content, heart muscle disturbances as revealed by electrocardiogram and hypertensive changes in the fundus, 4. The majority of the hearing type belong to abrupt type of high tone-loss, followed in the descending order of gradual type, horizontal type and dip type. In the age over 60 years the gradual type tends to increase as compared with the age range in forty and fifty years. In examining 38 cases with presbycusis out of those examined in the part ‡T by means of automatic audiometer, the author studied mainly the amplitude in the automatic audiogram, and odtained the following results. Moreover, the classification of the amplitude in the 26 ears of normal adults is divided into the amplitude decreasing type under 4 db, normal type between 5 db to 17 db, and the amplitude increasing type over 18 db. 1. Those showing the amplitude decreasing type amounted to 23 cases (60.5%); normal type 12 cases (31.5%); and the amplitude increasing type 3 cases (7.9%); and the majority of the amplitude decreasing type showed the decrease in the high tone area. 2. The amplitude decreasing type was found mostly in those with mild disorders, and it decreased along with the progress in hearing disorders. 3. The amplitude decreasing type was found mostly in high: while the increasing type in the abrupt type of high-tone-loss, gradual type and in the horirizontal type. 4. The amplitude decreasing type decreased, though slightly, along with the advance in age. 5. The tinnitus had no special association with the amplitude in the audiogram. 6. The amplitude decreasing type decreased along with the advance in the degrees of arteriosclerosis of retina and hypertensive changes. In the electroencephalographic examinations of 130 cases previously mentioned in the Part ‡T, the author studied the relationship between the electroencephalogram and the hearing in old age, and obtained the following results: 1. (Irregularity in) the wave legnth and the amplitude of ƒ¿-wave as well as the breakdown in the wave fomation are revealed more markedly along with the advance in the hearingloss. 2. Of the abnormal waves, slow wave and spike appear in a direct proportion to the degree of hearing-loss. 3. As the hearing-loss in the age range of forty and fifty years are milder, the same holds true of the changes in electroencephalogram in the majority of cases. In the age range over sixty years both tend to be more marked. 4. Most of those belonging to the amplitude decreasing type reveal a milder degree of electroencephalographic changes, en-copyright= kn-copyright= en-aut-name=SasakiAkira en-aut-sei=Sasaki en-aut-mei=Akira kn-aut-name=ù–Øù kn-aut-sei=ù–Ø kn-aut-mei=ù aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=10 article-no= start-page=3489 end-page=3517 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Leptospirosis in Ehime Prefecture kn-title=ˆ¤•QŒ§‰º‚É‚¨‚¯‚郌ƒvƒgƒXƒsƒ‰Ç‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although the leptospirosis in Ehime Prefecture is well-known and Minami-Uwa-Gun is particularly well-known as the prevailing district of this disease, no large scale examination is as yet reported. The author studied at first the endemic and the type of leptospira all over Ehime Prefecture, and then studied those in Minami-Uwa-Gun, the most heavily contaminated district. In parallel with this, the occurence of the vitreous body opacity in the leptospirosis was also studied. The following is a summary of the results obtained in this study: ‡T. Epidemiological study in Ehime Prefecture 1) Gosho district contains about 50% of all the cases of Weil's disease in Ehime Prefecture, and the distribution decreases in the sequence of Mibugawa, Yawatahama, Matsuyama and Uwajima districts. On cold plateaus and in intermountain regions, incidences are few. In Gosho district, the most heavily contaminated district, the soil pH is slightly acid. 2) In Ehime Prefecture, the average temperature of a year is 15‹C, the humidity is over 20% from June to September and the amount of rainfall from April to September is over 200 mm; a very good condition for the prevalence of leptospirosis. Incidences are the most in September. 3) This disease is more among the people of strong constitution with high working power, and is also more in the male than the female. 4) The cases of this disease are the most in farmers and the next in fishermen; the cases of each of these two are nearly 50% of all cases. 5) Some interrelation exist between the leptospirosis of a family and that of its domestic animals. ‡U. The leptospirosis in Gosho Public Health Office jurisdiction 1) About 50% of the cases exist in Nishi-Umimachi district, and less than this but pretty many cases are observed in Minami-Uchiumi, Shirobe, Higashi-Sotoumi and Gosho districts. 2) The prevalent regions are terraced fields and Rias type sea shores, which are the characteristics of the prevalent regions all over Japan, and especially fishing villages are wet and nasty and are massed by houses, giving a very good condition for the prevalence of the leptospirosis. 3) The climate of this district is that of the subtropical zone; wet and the average temperature of a year of 18Ž. 4) The morbidity rate was 1.0% of 7350 people tested. 5) As for the type of leptospira, Weil and Akiyami types are rather many, Particularly Akiyami C type is many, which is usually considered rather less. 6) The Akiyami C strain isolated from the dog is the third one of this strain isolated in Japan. ‡V. The Antibody distribution in Ehime Prefecture 1) Of 511 dogs tested, 105 (20.5%) showed a positive reaction, and the positive reaction rate was higher in southern districts. The type of the agent was L. canicola, Weil and Akiyami C. 2) Of 663 horses and tattles, 137 (23.5%) showed a positive reaction, and the positive reaction cases are many in Gosho and Imaharu districts. As for the type of the agent, Akiyami B was the most and the next was Weil, Akiyami A and Akiyami C. The interrelation between the vitreous body opacity and the leptospirosis Of 32 patients with vitreous body opacity, 17 cases (56.3%) showed a positive serum agglutination reaction. Of all the types of the agent found in these patients, each of weil and Akiyami types occupies about 50%, and, of the latter, Akiyami C type was about 25%. The vitreous body opacity appeared about 8 months after the onset of leptospirosis. en-copyright= kn-copyright= en-aut-name=OkadaHiroshi en-aut-sei=Okada en-aut-mei=Hiroshi kn-aut-name=‰ª“cŒ[ kn-aut-sei=‰ª“c kn-aut-mei=Œ[ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ˆ¤•QŒ§—§‰q¶Œ¤‹†Š END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=1 article-no= start-page=137 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Weil-Felix Reaction of Rickettsia tsutsugamushi The Investigatign on the Weil-Felix Reaction on the Basis of the Concept of 50% Agglutination Titer kn-title=Weil-Felix”½‰ž‚ÉŠÖ‚·‚錤‹†50%‹ÃW‰¿‚ÌŠT”O‚É‚à‚Æ‚¸‚­Weil-Felix”½‰ž‚Ì‹á–¡ en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the diagnosis of rickettsial diseases, though there are agglutination and complement fixation tests with the use of pure rickettsial suspension, the Weil-Felix test is still of high value for its technical simplicity and specificity. Even in the case of Tsutsugamushi disease, Fletcher, Wolf, Felix and Kawamura applied the Weil-Felix reaction with the use of Proteus OXK bacilli, and since then this reaction has been discussed in various ways, but the true antibody titer seems not to be obtained because of the insufficient consideration of the antigen concentration. Especially when the variation in the production of antibody is discussed on the basis of antibody titer, there apt to be misinterpretations. By the Weil-Felix reaction with the use of Proteus OXK dacilli suspension of 50% agglutination titer as the antigen, the author examined the variation of the antibody production in the sera of the test animals inoculated with rickettsiae, in parallel with the case in which the antigen was selected at random in the conventional way. As the result, it was found that when the antigen of 50% agglutination titer was used, no variation was shown in the antibody titer, irrespective of the sites of inoculation, the number of times of inoculation, life or death of rickettsiae, while, in the case of antigen selected at random, variable titers were yielded. From these data, the author believes that the antigen concentration suitable for she Weil-Felix reaction has been found. en-copyright= kn-copyright= en-aut-name=KajikiIkuo en-aut-sei=Kajiki en-aut-mei=Ikuo kn-aut-name=Š–؈è•v kn-aut-sei=Š–Ø kn-aut-mei=ˆè•v aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”w“àŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1-3 article-no= start-page=125 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Bilirubinoid-Azopigments Part ‡U: Spectrophotometrical Studies of the Diazo Reaction on the Bilirubinoids of Bilirubin, Mesobilirubin and Bilirubindimethylester kn-title=Bilirubinoid-AzoF‘f‚ÉŠÖ‚·‚錤‹† ‘æ2•Ò ”Žíbilirubinoid‚Ìdiazo”½‰ž‚Ì•ªŒõ‰»Šw“IŒ¤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=The process on the indirect diazo reaction after adding methanol to the bilirubinoids of bilirubin, mesobilirubin and bilirubindimethylester have been studied spectrophotometrically, the diazotised sulfanilic acid was used on the diazo reaction. The following results were obtained; Bilirubin-azopigment showed an absorption@maximum at 560 mƒÊ, and also at 420 mƒÊ before the reaction was completed. The time to reach the absorption maximum at 560 mƒÊ prolonged in parallel with a decrease of the amount of the diazo reagent, and also the absorption maximum at 420 mƒÊ remained higher. The same results to the above were found in mesbilirubin-azopigment, except showing the absorption maximum at 550 mƒÊ and at 390 mƒÊ before the reaction was completed. Again the same results were found in bilirubindimethylester-azopigment, except showing the absorption maximum at 540 mƒÊ and at 410 mƒÊ before the reaction was completed. The absorption maximum of the bilirubin-azopigment at 560 mƒÊ was flattened by leaving it in room, showing the more remarkable change along with a increase of amount of the diazo reagent. The same results were also found in the azopigments of the mesobilirubin and bilirubin dimethylester, but having slight differences in positions of the maximum absorption. After leaving the bilirubinoid in room, a maximum absorption was appeared at 400 to 420 mƒÊ in the case having a plenty amount of diazo reagent, which was found to result from the excess amount of the reagent remained in the reacting solution. All of the acid azopigments, yielded after the addition of HCl to the each azopigments of bilirubin, mesobilirubin and bilirubindimethylester, showed their maximum absorption at 580 mƒÊ, a very stable character and no significant change on the absorption curve by leaving them in room for a week. en-copyright= kn-copyright= en-aut-name=KanedaKotaro en-aut-sei=Kaneda en-aut-mei=Kotaro kn-aut-name=‹à“c᧑¾˜Y kn-aut-sei=‹à“c kn-aut-mei=᧑¾˜Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=1-2 article-no= start-page=117 end-page=122 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Prevention of Serum Hepatitis Part ‡U. The Infectivity Period of the Blood Bonors with a History of Viral Hepatitis kn-title=ŒŒ´ŠÌ‰Š‚Ì—\–h‚ÉŠÖ‚·‚錤‹† ‘æ2•Ñ ŠÌ‰ŠŠù‰ŽÒŒŒ‰t‚̈À‘S« en-subtitle= kn-subtitle= en-abstract= kn-abstract=Of 137 blood recipients from the blood donors with a history of infectious hepatitis, 61 recipients were examined in terms of liver function tests for more than 3 months. The results obtained were as follows: 1. There was no incidence of serum hepatitis except 2 cases in the recipients who received blood from the donors who had been suffered from hepatitis before 1956. 2. Out of 29 cases, 9 cases including 4 cases icteric serum hepatitis were proved to be the subjects received blood from the donors with a history of hepatitis after 1957. Comparing with the incidence rate of serum hepatitis by the blood transfusion from the voluntary donors for a same period. The above mentioned rate is notably high, and this is almost equal to the rate of the incidence in the cases received blood from paid donors. 3. The incubation prid was within 30 days in 7 out of 11 cases with serum hepatitis. 4. The mixture of blood from the subjects with a history of viral hepatitis was found to be only one or two units, therefore the incidence of serum hepatitis was not increased with the amount of transfused blood. 5. The residential areas of the donors were in close association with the epidemic areas of infectious hepatitis. 6. Consequetly, it is concluded that those donors who have a history of hepatitis for the past 10 years and who have residence in the epidemic areas, should be eliminated from the choice of the blood donors. en-copyright= kn-copyright= en-aut-name=OkutomiZenkichi en-aut-sei=Okutomi en-aut-mei=Zenkichi kn-aut-name=‰œ•x‘P‹g kn-aut-sei=‰œ•x kn-aut-mei=‘P‹g aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=3-4 article-no= start-page=129 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1967 dt-pub=19670430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Tissue Culture of Spleen Part 1. On The Simplification of the Splenic Tissue Culture kn-title=äB‘Ÿ‘gD”|—{‚ÉŠÖ‚·‚錤‹† ‘æ1•Ò ”|—{–@‚̊ȈՉ»‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) On the simplification of the splenic tissue culture, the author studied the influences of the various serums and growth promoting substances upon the splenic tissue culture of mice, rabbits and rats. 2) Culturing these spleens with the unactivated serum or untreated serum, the author concluded that the splenic culture with the unactivated serum was superior to the latter in all data of cultures. 3) Culturing these spleens by adding vitamin B(12), folic acid or nucleic acid, which were on the market, for the growth promoting substances, both in mice and rats the cultures adding vitamin B(12) showed comparatively excellent growth, and in rabbits the cultures adding folic acid or vitamin B(12) showed somewhat good growth, between which significant difference was not shown. 4) On the basis of these results we called the following method the clinical tissue culture method of the spleen, in which the spleen was cultured in the medium composed of unactivated serum and vitamin B(12) (100(ƒÁ)/(c.c.)) using the Hiraki's tissue culture slide No. 1, and then the data using this tissue culture method was compared with those obtained by the conventional plasma clot culture method. These results showed that, although this method was slightly inferior to the plasma clot culture method in the data of cultures, it was sufficiently fit for clinical application. en-copyright= kn-copyright= en-aut-name=ShimazakiKoichi en-aut-sei=Shimazaki en-aut-mei=Koichi kn-aut-name=“‡èFˆê kn-aut-sei=“‡è kn-aut-mei=Fˆê aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=3-4 article-no= start-page=137 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Irradiation on Lipid Peroxidation In Rat Organs. Part ‡U. Changes in lipid peroxidation and ratio of fatty acid composition in rat organs after irradiation kn-title=ƒ‰ƒbƒg‘ŸŠí‚ÌŽ‰Ž¿‰ßŽ_‰»”½‰ž‚É‚¨‚æ‚Ú‚·•úŽËüƎ˂̉e‹¿ ‘æ2•Ò •úŽËüƎ˃‰ƒbƒg‘ŸŠí‚É‚¨‚¯‚鎉Ž¿‰ßŽ_‰»”½‰ž‚ÆŽ‰–bŽ_\¬”ä‚Ì•Ï“®‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=With four groups of rats, normal, irradiated, fasting, and irradiated-then-fasting rats (dose of X-ray, 650R), 48 hours afterwards, liver, heart, spleen and kidney were examined separately as to changes in the acceleration of lipid peroxidation and fatty acids due to irradiation were examined and obtained the results as follows. (1) The lipid peroxidation in each organ was accelerated after irradiation when compared to that in the organs of normal group. In the fasting group the acceleration of lipid peroxidation was observed, but the acceleration in the irradiated group was far more marked, indicating clearly the effect of irradiation. (2) As to changes in the ratio of fatty acid composition in every organ of the irradiated group there were observed an increase in the ratio of high unsaturated fatty acids and a decrease in the ratio of saturated fatty acids as compared with the respective values in normal group. Among organs there could be recognized no uniform change in the fasting group and the irradiated-then-fasting group. These results indicate that the fasting affects the ratio of fatty acid composition, especially marked was change in triglyceride fraction. (3) The lipid content in the liver tends to increase after irradiation, and there is also observed an incrase in the ratio of lipids to phospholipids. (4) The arachidonic acid of phospholipid what is considered to be substrate of lipid peroxidation is increased in the irradiated group, suggesting its relation to the acceleration of lipid peroxidation accompanying irradiation, and actually, the arachidonic acid ratio of phospholipid is markedly decreased after the incubation of lipid peroxidation reaction in the presence of Fe(++), indicating that this substance can play the role of substrate. en-copyright= kn-copyright= en-aut-name=WatanabeSetsuo en-aut-sei=Watanabe en-aut-mei=Setsuo kn-aut-name=“n•Ó߶ kn-aut-sei=“n•Ó kn-aut-mei=߶ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•úŽËüˆãŠw‹³Žº END start-ver=1.4 cd-journal=joma no-vol=92 cd-vols= no-issue=1-2 article-no= start-page=137 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An experimental-anatomical study on the auditory tectothalamic projections kn-title=’®Šo«Ž‹ŠWŽ‹°“ŠŽË‚ÉŠÖ‚·‚éŽÀŒ±‰ð–UŠw“IŒ¤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present study has been undertaken to clarify the ascending projections of the inferior colliculus (IC) to the posterior thalamus, particularly the medical geniculate body (MGB), using the Nauta-Gygax and Fink-Heimer methods. The ventrolateral part of the central nucleus of IC projects mainly to the laminated ventral principal part and the lateral portion of the magnocelluar part of MGB. The projections to the laminated ventral principal part are topically organized mediolaterally, i.e., the medial laminae of the central nucleus of IC project to the medial laminae of the ventral principal part of MGB, whereas the more lateral laminae of the central nucleus send fibers to the more lateral laminae of the ventral principal part of MGB. The projections of the central nucleus of IC to the laminated ventral principal part of MGB also appear to be organized anteroposteriorly and dorsoventrally. The dorsomedial part of the central nucleus of IC projects to the ventromedial portion of the ventral principal part, the magnocellular part, and the ventral portion of the dorsal principal part of MGB. The external nucleus of IC is situated lateral to the central nucleus and extends anteriorly to form the anterior extremity of IC. It projects to the magnocellular and ventral principal parts and to the ventral portion of the dorsal principal part of MGB, including the deep dorsal nucleus of Morest (1964). In addition, it sends fibers to the deeper layers of the superior colliculus (stratum griseum intermediale and profundum) and to the anterior pretectal and suprageniculate nuclei. The inferior colliculus projects to the nucleus of the brachium of the inferior colliculus and the interstitial nucleus of the inferior brachium and to the central gray of the midbrain. Each part of IC is connected with other parts by intrinsic fibers. IC sends fibers to the dorsal part of the contralateral inferior colliculus, particularly the dorsomedial part of the central nucleus, through the commissure of the inferior colliculus. Only a few fibers pass by way of the inferior brachium to MGB on the contralateral side. en-copyright= kn-copyright= en-aut-name=YamawakiMasaomi en-aut-sei=Yamawaki en-aut-mei=Masaomi kn-aut-name=ŽR˜e³b kn-aut-sei=ŽR˜e kn-aut-mei=³b aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æŽO‰ð–UŠw‹³Žº en-keyword=’®ŠoŒn kn-keyword=’®ŠoŒn en-keyword=‘@ˆÛ“ŠŽË kn-keyword=‘@ˆÛ“ŠŽË en-keyword=Ž‹° kn-keyword=Ž‹° END start-ver=1.4 cd-journal=joma no-vol=96 cd-vols= no-issue=1-2 article-no= start-page=137 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on antibodies to human null-acute lymphoblastic leukemia cell line (NALL-1). I.Monoclonal antibodies with specificities for HLA, Ia-like and human leukocyte common antigens. kn-title=Null×–EŒ^‹}«ƒŠƒ“ƒp‹…«”’ŒŒ•a×–EŠ”, NALL-I‚ɑ΂·‚émonoclonalR‘Ì‚Ì컂Ƃ»‚̉ðÍ ‘æ1•Ò 3Ží‚ÌmonoclonalR‘Ì,RHLA,RIa,R”’ŒŒ‹…‹¤’ÊRŒ´R‘Ì‚Ì“ÁˆÙ« en-subtitle= kn-subtitle= en-abstract= kn-abstract=Three monoclonal antibodies, designated H-1, H-2 and H-3, were produced by immunizing BALB/C mice with cells of an established human null-acute lymphoblastic leukemia (NALL-1) cell line and fusing spleen cells from these mice with cells of a mouse myeloma cell line, P3-NSl/1-AG4-1. The resulting hybrid cells were initially screened for production of antibodies by complement-dependent cytotoxicity. Stable monoclonal antibody-producing cell lines were isolated by repeated cloning. These independently derived monoclonal antibodies showed complement-dependent cytotoxicities. Further characterization of the monoclonal antibodies was made by immunofluorescence. H-1 antibody reacted with all tested cells of the human nucleated cells except for HLA-lacking Daudi and K562 cells, and thus was shown to be specific for a common antigenic dererminant of HLA-A,-B and-C. H-2 antibody reacted with all of the tested null-cell lines, B-cell lines, B-cells and monocytes. Moreover, studies on fresh leukemia and lymphoma cells revealed that tumor cells from null-acute lymphoblastic leukemia, B-chronic lymphocytic leukemia and null-non-Hodgkin's lymphoma were H-2 antibody reactive. Cells from some patients with acute myelogenous leukemia, acute monocytic leukemia, chronic myelogenous leukemia in blast crisis and abult T-cell leukemia were also H-2-positive. In contrast, T-acute lymphoblastic leukemia, T-nonHodgkin's lymphoma cells and mature T-cells did not react with H-2. A cross absorption study using H-2 and anti-HLA-DR monoclonal antibody confirmed the same specificity. Interestingly, H-2 showed blocking activities against the stimulation in one-way mixed lymphocyte culture. These results indicate that H-2 is a monoclonal antibody specific for a framework determinant of human Ia-like antigens. Reactivity of H-3 antibody was different from that of H-1 and H-2. H-3 reacted with some T-cells, B-cells and monocytes, suggesting that the antibody is associated with human leukocyte common antigens. en-copyright= kn-copyright= en-aut-name=HarutaYuro en-aut-sei=Haruta en-aut-mei=Yuro kn-aut-name=t“c—S˜Y kn-aut-sei=t“c kn-aut-mei=—S˜Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ2“à‰È en-keyword=Null-ALL cell line kn-keyword=Null-ALL cell line en-keyword=Monoclonal R‘Ì kn-keyword=Monoclonal R‘Ì en-keyword=RIaR‘Ì kn-keyword=RIaR‘Ì en-keyword=MLC inhibition kn-keyword=MLC inhibition END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue=1 article-no= start-page=137 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Measured Dissipated-Energy in Switching-off by Electric Contacts en-subtitle= kn-subtitle= en-abstract= kn-abstract=The measurement of the dissipated energy in switching-off has been attempted to make clear the function of spark on electric contacts, which may unfortunately cause the combustible gas, such as propane gas etc, to catch fire and result in fire accidents. By utilizing the "Memoriscope" has been the meaurement carried out and the feature of this method is to provide the information on not only the amount of dissipated energy involved in one action but also on the trace of its instantaneous power which can affect catching fire delicately. Presented in this paper are the discussion of this measuring method and the measured results which are obtained experimentally in order to investigate the dependence of the energy dissipation on variety of contacts, contacts' deterioration and circuit arrangements. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=HimeiToyoji kn-aut-sei=Himei kn-aut-mei=Toyoji aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=FujitsukaTakeshi kn-aut-sei=Fujitsuka kn-aut-mei=Takeshi aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=InoueJyunichi kn-aut-sei=Inoue kn-aut-mei=Jyunichi aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=KomatsubaraHitoshi kn-aut-sei=Komatsubara kn-aut-mei=Hitoshi aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=KadowakiMasahiko kn-aut-sei=Kadowaki kn-aut-mei=Masahiko aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Electrical Engineering affil-num=2 en-affil= kn-affil=Department of Electrical Engineering affil-num=3 en-affil= kn-affil=Department of Electrical Engineering affil-num=4 en-affil= kn-affil=Department of Electrical Engineering affil-num=5 en-affil= kn-affil=Identification Section, Oka)'ama Prefectural Police Hq END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue=1 article-no= start-page=133 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1967 dt-pub=19670401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Considerations of Linkages between Analog and Digital for Function x(n) en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper describes a method of hybrid computation for the problems including the function x(n). And the greater part of it is devoted to the considerations of the linkages between the analog and the digital for the function x(n). Here the function x(n) appears frequently in the form of x(2) or x(4) in the industrial problems. As is well known the function x(2) is the characteristic included in fluid-flow problems, and x(4) is in heat-radiation problems. The weak points of analog computation for these characteristics are in accuracy and stability, but can be compensated by making use of digital computer for these parts. In the industrial uses the exclusive digital computer is more convenient than the general-purpose one. Here the relative error of analog computation, the linkages, the number of the digital elements and their relationships are considered at the same time and as the results the reasonable method of hybrid computation is obtained. That is, the exclusive digital multiplier with a compressor and an expandor is found reasonable. Its design considerations are described in details, but it is the basic idea among others that the characteristics of the compressor and the expandor are determined so that the relative error of the signal appearing at the output of the latter may be constant and as the results the necessary and sufficient number of the digital elements may be decreased. And in practice these characteristics are also realized approximately by a group of the straight lines through the origin. Finally the reduced rate of the digital elements and the optimum condition of the approximation are illustrated together with an example. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=MisakiTakayoshi kn-aut-sei=Misaki kn-aut-mei=Takayoshi aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=OkamotoTakuji kn-aut-sei=Okamoto kn-aut-mei=Takuji aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Electrical Engineering affil-num=2 en-affil= kn-affil=Department of Electrical Engineering END start-ver=1.4 cd-journal=joma no-vol=1 cd-vols= no-issue=1 article-no= start-page=134 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=19660331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On the Aging and Precipitation of Al-Ag and Al-Zn Alloys en-subtitle= kn-subtitle= en-abstract= kn-abstract=Polycrystalline specimens of Al-30wt % Ag and Al-30wt % Zn alloys, which were quenched into water from the temperature of solution heat treatment, were annealed at L.T. aging temperatures or reversion temperatures so as to make them contain zones of nearly equal radii for each alloy and various concentrations of solute element in zones. These specimens were cold rolled exactly to 50%, and then annealed at L. T. aging temperatures for varying time. The state of zones and precipitates were investigated by X-ray small-angle scattering photographs. The results obtained were as follows: (1) The precipitation ofƒÁ'-phase began earlier in the specimens of Al-Ag alloy annealed at L. T. aging temperature before cold rolling than in those specimens annealed at reversion temperatures before cold rolling when annealed at L. T. aging temperatures after cold rolling. (2) The rate of precipitation of Zn solid solution in Al-Zn alloy did not depend upon the annealing temperature before cold rolling when cold rolled specimens were annealed at L. T. aging temperature. (3) In Al-Ag alloy, the rate of disappearance of G. P. zones at L. T. aging temperature depends mainly upon the annealing temperature before cold rolling. On the other hand, in Al-Zn alloy, the rate of disappearance of G. P. zones at L. T. aging temperature does not depened upon the annealing temperature before cold rolling. (4) These results may be explained without contradiction considering the relation of structures between matrix and precipitates and the deformation stacking faults. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=OhtaMutsuo kn-aut-sei=Ohta kn-aut-mei=Mutsuo aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Department of Industrial Science END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1-2 article-no= start-page=137 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Characteristics of a Monoacylglycerol Lipase Isolated from Pseudomonas sp. LP7315 -Hydrolysis and Synthesis of Monoglycerides en-subtitle= kn-subtitle= en-abstract= kn-abstract=A monoacylglycerol lipase (MGL) was purified from Pseudomonas sp. LP7315 by ammonium sulfate precipitation, anion-exchange chromatography, and preparative electrophoresis. The purified enzyme was homogeneous on an SDS-polyacrylamide gel with a molecular mass of 59 kDa. Its hydrolytic activity was confirmed to be specific for monoglycerides: the enzyme did not hydrolyze diand triglycerides. MGL was found to be stable even after l-h incubation at 65Ž. The hydrolytic activity depended not only on temperature and pH but also on the type of monoglyceride used. MGL also catalyzed monoglyceride synthesis at 65Ž in a solvent-free two-phase system, in which fatty acid droplets were dispersed in the glycerol phase with a low water content. The synthetic reaction proceeded at a constant rate for approximately 24 h and reached an equilibrium after 48 h of reaction. The initial rate of the synthetic reaction depended on several factors: the type of fatty acid used as the substrate, the amounts of fatty acid and glycerol, and the concentration of MGL in the glycerol phase. To analyze the effects of these factors, a kinetic model was developed based on the assumption that the adsorption equilibrium of MGL molecules at the interface between the two phases is the rate-determining factor for the synthetic reaction. The model was found to yield a good approximation of the initial synthetic rate under various reaction conditions. The analysis suggests that the adsorption behavior of MGL onto the interface had a large effect on the initial rate of the monoglyceride synthesis. en-copyright= kn-copyright= en-aut-name=SakiyamaTakaharu en-aut-sei=Sakiyama en-aut-mei=Takaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshimiTsuyoshi en-aut-sei=Yoshimi en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MiyakeAkira en-aut-sei=Miyake en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UmeokaMidori en-aut-sei=Umeoka en-aut-mei=Midori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaAtsushi en-aut-sei=Tanaka en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OzakiSho en-aut-sei=Ozaki en-aut-mei=Sho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakanishiKazuhiro en-aut-sei=Nakanishi en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=2 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=3 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=4 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=5 en-affil= kn-affil=Daiwa Kasei K.K. affil-num=6 en-affil= kn-affil=Daiwa Kasei K.K. affil-num=7 en-affil= kn-affil=Department of Bioscience and Biotechnology END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=2 article-no= start-page=137 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pre-operative anxiety and nursing care - Through two students'case studies on surgical patients - kn-title=Žèp‚ðŽó‚¯‚銳ŽÒ‚Ìp‘O•sˆÀ‚Ì—‰ð‚ƊŌ쉇• \Žó‚¯Ž‚Á‚½ŽèpŠ³ŽÒ‚ÌŽ–—ጤ‹†‚ð’Ê‚µ‚ÄŠw¶‚ªŠw‚ñ‚¾‚±‚Æ\ en-subtitle= kn-subtitle= en-abstract=Pre-operative nursing is to care and educate a patient so that he/she can undergo an operation at ease and in safety and recover quickly after surgery. One of the pre-operative nursing is to relieve anxiety. It's very important for pre-operative nursing to assess pre-operative anxiety and do the nursing action according to patient's anxiety level. Nursing student seems to have much understanding of pre-operative anxiety through observing a patient's behavior, talking with a patient, and caring a patient in clinical practice. Two students'case studies on surgical patients are presented in this paper. This paper shows how they promote deeper understanding of pre-operative anxiety and the nursing care is promoted by observing the patient and listening objectively to what the patient says and giving appropriate feedback. kn-abstract=Žèp‘O‚ÌŠÅŒì‚Í,Š³ŽÒ‚ªˆÀ‘S¥ˆÀŠy‚ÉŽèp‚ðŽó‚¯‚邱‚Æ‚ª‚Å‚«,pŒã‚̉ñ•œ‰ß’ö‚ªƒXƒ€[ƒY‚É‚¢‚­‚悤‚ɉ‡•‚·‚邱‚Æ‚Å‚ ‚é.‚»‚ÌŠÅŒì‚̈ê‚‚Ƃµ‚Äp‘O•sˆÀ‚̊ɘa‚ÉŒü‚¯‚Ẳ‡•‚ª‚ ‚éB‚»‚Ìl‚Ì•sˆÀƒŒƒxƒ‹‚ɉž‚¶‚½“K؂ȊŌ쉇•‚ðs‚¤‚½‚ß‚É‚Í,Š³ŽÒ‚Ì•sˆÀ‚𳂵‚­ƒAƒZƒXƒƒ“ƒg‚·‚邱‚Æ‚ªd—v‚É‚È‚é¡ŠÅŒìŠw¶‚É‚Æ‚Á‚Ä,Š³ŽÒ‚Ì•sˆÀ‚Ö‚Ì—‰ð‚Í,—Õ°ŽÀK‚Ìê‚Å,Š³ŽÒ‚ðŠÏŽ@‚µ‚½‚è,Š³ŽÒ‚ÆŒü‚«‡‚Á‚Ęb‚ðŒð‚킵‚½‚è,ƒPƒA‚ðs‚Á‚½‚è‚·‚é‘ÌŒ±‚ð’Ê‚µ‚Ä”|‚í‚ê‚Ä‚¢‚­‚à‚Ì‚Å‚ ‚é‚ÆŽv‚í‚ê‚é¡–{˜_•¶‚Å‚Í,2–¼‚ÌŠw¶‚ªs‚Á‚½p‘O•sˆÀ‚ÉŠÖ‚·‚鎖—ጤ‹†‚©‚ç,‹qŠÏ“I‚É•ªÍ‚·‚é•û–@‚ð—p‚¢‚ÄŠ³ŽÒ‚ðŠÏŽ@‚µ‚½‚è, Š³ŽÒ‚̘b‚ð•·‚¢‚½‚è,ŠÅŒìsˆ×‚ðs‚¤‚±‚Æ‚É‚æ‚Á‚Ä,p‘O•sˆÀ‚ƊŌ쉇•‚Ì—‰ð‚ª[‚ß‚ç‚ê‚邱‚Æ‚ð˜_q‚µ‚½¡ en-copyright= kn-copyright= en-aut-name=HayashiYuko en-aut-sei=Hayashi en-aut-mei=Yuko kn-aut-name=—Ñ—DŽq kn-aut-sei=—Ñ kn-aut-mei=—DŽq aut-affil-num=1 ORCID= en-aut-name=OkazakiMegumi en-aut-sei=Okazaki en-aut-mei=Megumi kn-aut-name=‰ªèŒb kn-aut-sei=‰ªè kn-aut-mei=Œb aut-affil-num=2 ORCID= en-aut-name=SumiKumiko en-aut-sei=Sumi en-aut-mei=Kumiko kn-aut-name=ŠpŒö”üŽq kn-aut-sei=Šp kn-aut-mei=Œö”üŽq aut-affil-num=3 ORCID= en-aut-name=SatoYoshie en-aut-sei=Sato en-aut-mei=Yoshie kn-aut-name=²“¡”üŒb kn-aut-sei=²“¡ kn-aut-mei=”üŒb aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”ŠÅŒìŠw‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ affil-num=3 en-affil= kn-affil=“‡ªŒ§—§‘‡ŠÅŒìŠw‰@ affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”ŠÅŒìŠw‰È en-keyword=CABG‚ðŽó‚¯‚銳ŽÒ (Coronary artery bypass grafting patient) kn-keyword=CABG‚ðŽó‚¯‚銳ŽÒ (Coronary artery bypass grafting patient) en-keyword=‰E”x‰º—tØœp‚ðŽó‚¯‚銳ŽÒ (Robectomy patient) kn-keyword=‰E”x‰º—tØœp‚ðŽó‚¯‚銳ŽÒ (Robectomy patient) en-keyword=p‘O•sˆÀ (Pre-operative anxiety) kn-keyword=p‘O•sˆÀ (Pre-operative anxiety) en-keyword=p‘O•sˆÀ‚ւ̊Ō쉇• (Nursing care) kn-keyword=p‘O•sˆÀ‚ւ̊Ō쉇• (Nursing care) END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=2 article-no= start-page=137 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‘æ108‰ñ@‰ªŽRˆãŠw‰ï‘‰ï en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ªŽRˆãŠw‰ï kn-aut-sei=‰ªŽRˆãŠw‰ï kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue= article-no= start-page=137 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‹ÆÑW en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ŽO’©ˆã—ÃZƒ“ƒ^[ kn-aut-sei=ŽO’©ˆã—ÃZƒ“ƒ^[ kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=3-4 article-no= start-page=299 end-page=308 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and experimental studies on provocating and reducing mechanism of intractable pain Part 2. ƒÀ-endorphin and monoamine metabolites in CSF of the patient with chronic pain -comparison of the concentration between pre- and post-stimulation of CNS kn-title=Šæ’É‚Ì”­¶‚¨‚æ‚Ñ—}§‚ÉŠÖ‚·‚éŠî‘b“IE—Õ°“IŒ¤‹†@‘æ2•Ò@Šæ’ÉŠ³ŽÒ‚ɉ—‚¯‚鑉t’† ƒÀ-endorphin ‚¨‚æ‚Ñ monoamine ‘ãŽÓŽY•¨\’†•_ŒoŒn‚Ì“d‹CŽhŒƒ‘OŒã‚ɉ—‚¯‚é”Z“x•Ï“®‚ɂ‚¢‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The concentration of ƒÀ-endorphin-immunoreactivity (ƒÀ-END-IR) and monoamine metabolites which are 3-methoxy-4-hydroxy-phenylglycol (MHPG), homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) were measured in cerebrospinal fluid (CSF) of patients with intractable pain to estimate the participation of these substances in the mechanism of intractable pain. The amount of ƒÀ-END-IR and monoamine metabolites was measured with radioimmunoas-say and HPLC (hight performance liquid chromatography), respectively. Eight cases of intractable pain were treated with impantation of the stimulating electrode for pain relief. This treatment was performed in 2 ways, deep brain stimulation (DBS) done on 6 cases and spinal dorsal column stimualtion (DCS) on 2 cases. The concentrations of ƒÀ-END-IR and monoamine metabolites were also estimated before and after the stimulation. No patient treated with DBS showed the elevation of ƒÀ-END-IR or monoamine metabolites after the stimulation, except for one patient who showed significant increase of monoamine metabolites accompanying excellent pain relief by the stimulation. On the other hand, the two patients treated with DCS indicated significant elevation of ƒÀ-END-IR as well as monoamine metabolites. Thus, both ƒÀ-END and monoamines could play as important role DCS, and that monoamine could be involved in DBS for pain relief. en-copyright= kn-copyright= en-aut-name=FujiwaraNoriaki en-aut-sei=Fujiwara en-aut-mei=Noriaki kn-aut-name=“¡Œ´‘¥Í kn-aut-sei=“¡Œ´ kn-aut-mei=‘¥Í aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•””]_ŒoŠO‰È‹³Žº en-keyword=ƒÀ-endorphin kn-keyword=ƒÀ-endorphin en-keyword=monoamine kn-keyword=monoamine en-keyword=pain kn-keyword=pain en-keyword=CSF kn-keyword=CSF en-keyword=stimulation of CNS kn-keyword=stimulation of CNS END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=1 article-no= start-page=137 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=19660130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ˆÝ–À“üäX‚Ì2—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors reported two cases of aberrant pancreas in the stomach. Out of 2, 430 cases who were examined with gastrocamera, two cases of aberrant pancreas in the stomach were found. Case 1 was a 31 year-old male. Case 2 was 41 year-old female. They were diagnosed radiologically and endoscopically as submucosal tumor of the stomach and were gastrectomyzed. The resected specimens were diagnosed histologically as aberrant pancreas. The importance of the radiologic and endoscopic findings of aberrant pancreas in the stomach was discussed. en-copyright= kn-copyright= en-aut-name=KiharaTsuyoshi en-aut-sei=Kihara en-aut-mei=Tsuyoshi kn-aut-name=–ØŒ´‹® kn-aut-sei=–ØŒ´ kn-aut-mei=‹® aut-affil-num=1 ORCID= en-aut-name=TsuziOsamu en-aut-sei=Tsuzi en-aut-mei=Osamu kn-aut-name=’ÒÉ kn-aut-sei=’Ò kn-aut-mei=É aut-affil-num=2 ORCID= en-aut-name=HirohataNoboru en-aut-sei=Hirohata en-aut-mei=Noboru kn-aut-name=œA”¨“o kn-aut-sei=œA”¨ kn-aut-mei=“o aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ1“à‰ÈŠw‹³Žº affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ1“à‰ÈŠw‹³Žº affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ1“à‰ÈŠw‹³Žº END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=153 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes in dopamine D-1 and D-2 receptors in the rat striatum after long term treatment with haloperidol-Comparison among intermittent, continuous and very long term treatment kn-title=ƒnƒƒyƒŠƒh[ƒ‹’·Šú“Š—^Œã‚̃‰ƒbƒgüð‘Ì D-1ED-2 Žó—e‘̂̕ω»\ŠÔŒ‡“Š—^EŽ‘±“Š—^E’´’·ŠúŽžŽ‘±“Š—^‚Ì”äŠr\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of long-term treatment with haloperidol (2mg/kg/day) on dopamine receptors in the rat striatum was examined using in vitro quantitative autoradiography. Rats treated with haloperidol showed an increase in striatal D-2 receptor binding as revealed by [(3)H] spiperone. Striatal D-1 receptos labeled with [(3)H] SCH 23390 were not changed following treatment with haloperidol in young rats for 2 weeks, while, it was decreased following 85 weeks of tretment. The striatal D-1 receptors were decreased also after a 4 week treatment with haloperidot in aged rats. These results suggest that haloperidol treatment in the aged rats results in D-2 receptor supersensitivity and a decline in D-1 receptors. Such relative supersensitivity of the D-2 receptor over the D-1 receptor may be related to the vulnerability to tardive dyskinesia of the aged. en-copyright= kn-copyright= en-aut-name=NishikawaHiroshi en-aut-sei=Nishikawa en-aut-mei=Hiroshi kn-aut-name=¼ì_ kn-aut-sei=¼ì kn-aut-mei=_ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”_Œo¸_ˆãŠw‹³Žº en-keyword=dopamine receptors kn-keyword=dopamine receptors en-keyword=haloperidol kn-keyword=haloperidol en-keyword=aging kn-keyword=aging en-keyword=striatum kn-keyword=striatum en-keyword=tardive dyskinesia kn-keyword=tardive dyskinesia END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=143 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Integration and expression of E1 region DNA in human adenovirus type 12-induced tumors kn-title=ƒqƒgƒAƒfƒmƒEƒBƒ‹ƒX12Œ^—U”­Žîᇂɂ¨‚¯‚éE1—̈æˆâ“`Žq‚Ì‘g‚Ýž‚Ý‚Æ”­Œ» en-subtitle= kn-subtitle= en-abstract= kn-abstract=Integration and expression of human adenovirus type 12 (Ad12) were studied on two Ad12-induced tumor lines of C3Hf/OK mouse origin (IC and D tumors). Southern hybridization using whole Ad12 genome as probe demonstrated that DNA of IC and D tumors contained about 9 and 23 copies, respectively, of the entire Ad12 genome eqivalent per diploid cell. Left ends of Ad12 DNA appeared as off-size bands, indicating their linkage to different cellular DNAs. Southern hybridization using and Ad12 EcoRI-C fragment containing the E1 region as a probe revealed that intergration sites were much fewer than presumen numbers of integrated Ad12 genones. These results suggested that the viral and cellular DNA complex was repeated at integration sites. Northen hybridization using an Ad12 EcoRI-C fragment as a probe showed that tha E1 region was transcribed in both IC and D tumors. Much more intensive expression in the D tumor suggested possible dependence of the expression of the E1 region on the copy numbers of Ad12 genomes. en-copyright= kn-copyright= en-aut-name=MorikawaTomoko en-aut-sei=Morikawa en-aut-mei=Tomoko kn-aut-name=Xì’qŽq kn-aut-sei=Xì kn-aut-mei=’qŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ìˆã‰È‘åŠw•a—ŠwuÀ‘æˆê•a—Šw en-keyword=ƒqƒgƒAƒfƒmƒEƒBƒ‹ƒX12Œ^ kn-keyword=ƒqƒgƒAƒfƒmƒEƒBƒ‹ƒX12Œ^ en-keyword=E1—̈æ kn-keyword=E1—̈æ en-keyword=C3Hf/OK ƒ}ƒEƒX kn-keyword=C3Hf/OK ƒ}ƒEƒX en-keyword=ƒEƒBƒ‹ƒX”­Šà kn-keyword=ƒEƒBƒ‹ƒX”­Šà END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=445 end-page=454 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Usefulness of body surface maps for discriminating old myocardial infarction in cases with ECG findings of poor R wave progression kn-title=Poor R Wave Progression —á‚É‚¨‚¯‚é’‹Œ«‘O•Ç[Ç‚ÌŠÓ•Ê\‘Ì•\–ÊS‘Ÿ“dˆÊ}‚É‚æ‚錟“¢\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinical usefulness of the body surface maps (maps) to discriminate old anterior myocardial infarction (OAMI) in patients whose ECG showed poor R wave progression (PRWP) was examined. The maps of 60 patients with PRWP, including 33 cases of OAMI and 27 without myocardial infarction (non-MI) were recorded. The multivariate stepwise discriminant analysis elucidated that 5 leads (G4, C3, J5, B3, A5) of the QRST area map would contribute to the discrimination of OAMI from non-MI, and the the formula z=-6.0~G4+26.8~C3+9.1~J5-14.0~B3-9.0~A5-1.1(unit : 0.1mVS), using these parameters two groups were separated with a sensitivity of 90.9% and a specificity of 96.3%. The discriminating performance using 5 leads (G4, H2, H4, L6, M5)of the QRS area map and 5 leads (G5, G2, H4, L5, M5) of the Q20 map gave a sensitivity of 90.9%, and 93.9%, and specificity of 96.3%, and 92.6%, respectively. Furthermore, for formula was applied to 26 new consecutive patients with PRWP for evaluating this formula. The indicies obrained from the QRST area map gave the best results, and provided a sensitivity of 85.7% and a specificity of 100%. In the pattern of the QRST area map, the existence of the regions less than-20ƒÊVS can fairly identify the OAMI (sensitivity 87.9%, specificity 85.2%). These findings suggest that the mathematical models obtained from the result of map analysis, especially QRST area maps, are useful to discriminate OAMI among the cases with PRWP. en-copyright= kn-copyright= en-aut-name=IharaKeiko en-aut-sei=Ihara en-aut-mei=Keiko kn-aut-name=ˆäŒ´ŒhŽq kn-aut-sei=ˆäŒ´ kn-aut-mei=ŒhŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰ÈŠw‹³Žº en-keyword=old myocardial infraction kn-keyword=old myocardial infraction en-keyword=body surface mapping kn-keyword=body surface mapping en-keyword=poor R wave progression kn-keyword=poor R wave progression END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=435 end-page=444 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on serum factors in patients with bronchal asthma Part 2. Changes in serum levels of complement factors, C3 (ƒÀ(1c/1A)), & C4(ƒÀ(1E)) in patients with bronchial asthma kn-title=‹CŠÇŽxšb‘§‚É‚¨‚¯‚é‘̉tˆöŽq‚ÉŠÖ‚·‚錤‹† ‘æ2•Ò •â‘ÌŒnC3 (ƒÀ(1c/1A)), C4(ƒÀ(1E)) ’l‚Ì•Ï“®‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=Serum C3 and C4 levels were measured in 23 healthy subjects and 105 patients with bronchial asthma, by an immunodiffusion method using M-Partigen Plates. The serum levels of C4 were significantly increased in patients over 60 years old compared to the healthy subjects. The levels of C3 were significantly higher in male cases than in female cases with bronchial asthma. The serum levels of C3 and C4 in asthma patients with infectious type, in severe cases and in cases with steroid therapy were within the normal limits during non-attack periods, but significantly increased during attack periods. In asthmatic patients with mixed and infectious type, and in mild and severe cases, a significant correlation was observed between the serum levels of C3 and C4 during their non-attack periods. en-copyright= kn-copyright= en-aut-name=IshibashiKen en-aut-sei=Ishibashi en-aut-mei=Ken kn-aut-name=΋´Œ’ kn-aut-sei=΋´ kn-aut-mei=Œ’ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰ÈŠw‹³Žº en-keyword=‹CŠÇŽxšb‘§ kn-keyword=‹CŠÇŽxšb‘§ en-keyword=C3 kn-keyword=C3 en-keyword=C4 kn-keyword=C4 END