start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year= dt-pub= dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Turritis glabra L. kn-title=ハタザオ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-keyword=アブラナ科 (Brassicaceae) kn-keyword=アブラナ科 (Brassicaceae) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year= dt-pub= dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Amsinckia lycopsoides (Lehm.) Lehm. kn-title=ワルタビラコ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-keyword=ムラサキ科 (Boraginaceae) kn-keyword=ムラサキ科 (Boraginaceae) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year= dt-pub= dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Silene dichotoma Ehrh. kn-title=マンテマモドキ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-keyword=ナデシコ科 (Caryophyllaceae) kn-keyword=ナデシコ科 (Caryophyllaceae) END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=2 article-no= start-page=125 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effectiveness of team-based learning (TBL) as a new teaching approach kn-title=新教育技法「チーム基盤型学習（TBL）」の有用性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SunoManabu en-aut-sei=Suno en-aut-mei=Manabu kn-aut-name=須野学 kn-aut-sei=須野 kn-aut-mei=学 aut-affil-num=1 ORCID= affil-num=1 en-affil=Center for the Development of Medical and Health Care Education, Okayama University kn-affil=岡山大学医療教育統合開発センター en-keyword=アクティブラーニング（active learning） kn-keyword=アクティブラーニング（active learning） en-keyword=チーム基盤型学習（team-based learning） kn-keyword=チーム基盤型学習（team-based learning） en-keyword=問題基盤型学習（problem-based learning） kn-keyword=問題基盤型学習（problem-based learning） END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=139 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organized and Sustainable Education Program for Drug Abuse Prevention by Yogo-teachers kn-title=養護教諭が推進する組織的で継続可能な小学校の喫煙・飲酒・薬物乱用防止教育プログラムの開発と実践 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　学校における喫煙・飲酒・薬物乱用防止教育の充実には，問題行動が顕在化する中学校期だけでなく小学校期 における指導の推進が重要であり，系統的な指導計画を立て，指導者や時間の確保，教材作成などに組織的に取 組み，継続可能なプログラム開発を行う必要がある。そこで，地区内12 校の養護教諭が協働して，発達段階に応 じた系統的・組織的かつ継続可能な地区共通の指導計画を開発し，各校の教育課程・年間計画に位置付けた実践 研究を行った。その結果，指導計画の実施状況は，小学校11 校中，学級活動10 校，ミニ保健指導10 校，長期 休業前指導6 校，広報活動9 校となり，特別支援学校1 校では広報活動のみを行うことができた。小学校におけ る喫煙・飲酒・薬物乱用防止教育の推進には，学校保健活動の中核的役割を担う養護教諭が専門性を活かし協働 して，系統的な指導計画を各校の教育課程に位置付け組織的で継続可能なプログラムとする取組が有効であった。 en-copyright= kn-copyright= en-aut-name=UenoYoshiko en-aut-sei=Ueno en-aut-mei=Yoshiko kn-aut-name=上野芳子 kn-aut-sei=上野 kn-aut-mei=芳子 aut-affil-num=1 ORCID= en-aut-name=NishimuraTakae en-aut-sei=Nishimura en-aut-mei=Takae kn-aut-name=西村孝江 kn-aut-sei=西村 kn-aut-mei=孝江 aut-affil-num=2 ORCID= en-aut-name=HosakaSayuri en-aut-sei=Hosaka en-aut-mei=Sayuri kn-aut-name=保坂小百合 kn-aut-sei=保坂 kn-aut-mei=小百合 aut-affil-num=3 ORCID= en-aut-name=YamamotoMasae en-aut-sei=Yamamoto en-aut-mei=Masae kn-aut-name=山本雅恵 kn-aut-sei=山本 kn-aut-mei=雅恵 aut-affil-num=4 ORCID= en-aut-name=AkasakaRie en-aut-sei=Akasaka en-aut-mei=Rie kn-aut-name=赤坂理恵 kn-aut-sei=赤坂 kn-aut-mei=理恵 aut-affil-num=5 ORCID= en-aut-name=ArimatuAyumi en-aut-sei=Arimatu en-aut-mei=Ayumi kn-aut-name=有松亜由美 kn-aut-sei=有松 kn-aut-mei=亜由美 aut-affil-num=6 ORCID= en-aut-name=FujiiHarue en-aut-sei=Fujii en-aut-mei=Harue kn-aut-name=藤井治江 kn-aut-sei=藤井 kn-aut-mei=治江 aut-affil-num=7 ORCID= en-aut-name=YuguchiMakoto en-aut-sei=Yuguchi en-aut-mei=Makoto kn-aut-name=湯口真琴 kn-aut-sei=湯口 kn-aut-mei=真琴 aut-affil-num=8 ORCID= en-aut-name=TorigoeKanako en-aut-sei=Torigoe en-aut-mei=Kanako kn-aut-name=鳥越加奈子 kn-aut-sei=鳥越 kn-aut-mei=加奈子 aut-affil-num=9 ORCID= en-aut-name=OonishiMarika en-aut-sei=Oonishi en-aut-mei=Marika kn-aut-name=大西真莉香 kn-aut-sei=大西 kn-aut-mei=真莉香 aut-affil-num=10 ORCID= en-aut-name=NanbaYumiko en-aut-sei=Nanba en-aut-mei=Yumiko kn-aut-name=難波有美子 kn-aut-sei=難波 kn-aut-mei=有美子 aut-affil-num=11 ORCID= en-aut-name=MoriAyako en-aut-sei=Mori en-aut-mei=Ayako kn-aut-name=森文子 kn-aut-sei=森 kn-aut-mei=文子 aut-affil-num=12 ORCID= en-aut-name=WashidaHiroe en-aut-sei=Washida en-aut-mei=Hiroe kn-aut-name=鷲田洋恵 kn-aut-sei=鷲田 kn-aut-mei=洋恵 aut-affil-num=13 ORCID= en-aut-name=NishimotoKeiko en-aut-sei=Nishimoto en-aut-mei=Keiko kn-aut-name=西本圭子 kn-aut-sei=西本 kn-aut-mei=圭子 aut-affil-num=14 ORCID= en-aut-name=HinoYuko en-aut-sei=Hino en-aut-mei=Yuko kn-aut-name=日野裕子 kn-aut-sei=日野 kn-aut-mei=裕子 aut-affil-num=15 ORCID= en-aut-name=MatumotoTomoko en-aut-sei=Matumoto en-aut-mei=Tomoko kn-aut-name=松本智子 kn-aut-sei=松本 kn-aut-mei=智子 aut-affil-num=16 ORCID= en-aut-name=IshiharaTomoko en-aut-sei=Ishihara en-aut-mei=Tomoko kn-aut-name=石原智子 kn-aut-sei=石原 kn-aut-mei=智子 aut-affil-num=17 ORCID= en-aut-name=TodoMariko en-aut-sei=Todo en-aut-mei=Mariko kn-aut-name=藤堂真莉子 kn-aut-sei=藤堂 kn-aut-mei=真莉子 aut-affil-num=18 ORCID= en-aut-name=YamamotoKumiko en-aut-sei=Yamamoto en-aut-mei=Kumiko kn-aut-name=山本久美子 kn-aut-sei=山本 kn-aut-mei=久美子 aut-affil-num=19 ORCID= en-aut-name=SadamoriNatuki en-aut-sei=Sadamori en-aut-mei=Natuki kn-aut-name=定森奈月 kn-aut-sei=定森 kn-aut-mei=奈月 aut-affil-num=20 ORCID= en-aut-name=YamagamiNao en-aut-sei=Yamagami en-aut-mei=Nao kn-aut-name=山上奈緒 kn-aut-sei=山上 kn-aut-mei=奈緒 aut-affil-num=21 ORCID= en-aut-name=OkamotoKanako en-aut-sei=Okamoto en-aut-mei=Kanako kn-aut-name=岡本佳菜子 kn-aut-sei=岡本 kn-aut-mei=佳菜子 aut-affil-num=22 ORCID= en-aut-name=MatsuoHiromi en-aut-sei=Matsuo en-aut-mei=Hiromi kn-aut-name=松尾裕未 kn-aut-sei=松尾 kn-aut-mei=裕未 aut-affil-num=23 ORCID= en-aut-name=KobayashiShizuka en-aut-sei=Kobayashi en-aut-mei=Shizuka kn-aut-name=小林静香 kn-aut-sei=小林 kn-aut-mei=静香 aut-affil-num=24 ORCID= en-aut-name=HayashiKanako en-aut-sei=Hayashi en-aut-mei=Kanako kn-aut-name=林加奈子 kn-aut-sei=林 kn-aut-mei=加奈子 aut-affil-num=25 ORCID= en-aut-name=MizushimaNozomi en-aut-sei=Mizushima en-aut-mei=Nozomi kn-aut-name=水島希望 kn-aut-sei=水島 kn-aut-mei=希望 aut-affil-num=26 ORCID= en-aut-name=SekiyamaKen-ichi en-aut-sei=Sekiyama en-aut-mei=Ken-ichi kn-aut-name=関山賢一 kn-aut-sei=関山 kn-aut-mei=賢一 aut-affil-num=27 ORCID= en-aut-name=FukushimaTakashi en-aut-sei=Fukushima en-aut-mei=Takashi kn-aut-name=福嶋隆 kn-aut-sei=福嶋 kn-aut-mei=隆 aut-affil-num=28 ORCID= en-aut-name=KamimuraHiroko en-aut-sei=Kamimura en-aut-mei=Hiroko kn-aut-name=上村弘子 kn-aut-sei=上村 kn-aut-mei=弘子 aut-affil-num=29 ORCID= en-aut-name=TakahashiKayo en-aut-sei=Takahashi en-aut-mei=Kayo kn-aut-name=高橋香代 kn-aut-sei=高橋 kn-aut-mei=香代 aut-affil-num=30 ORCID= affil-num=1 en-affil= kn-affil=倉敷市立西阿知小学校 affil-num=2 en-affil= kn-affil=倉敷市立粒江小学校 affil-num=3 en-affil= kn-affil=倉敷市立連島北小学校 affil-num=4 en-affil= kn-affil=倉敷市立老松小学校 affil-num=5 en-affil= kn-affil=倉敷市立老松小学校 affil-num=6 en-affil= kn-affil=倉敷市立老松小学校 affil-num=7 en-affil= kn-affil=倉敷市立大高小学校 affil-num=8 en-affil= kn-affil=倉敷市立大高小学校 affil-num=9 en-affil= kn-affil=倉敷市立大高小学校 affil-num=10 en-affil= kn-affil=倉敷市立中洲小学校 affil-num=11 en-affil= kn-affil=倉敷市立中洲小学校 affil-num=12 en-affil= kn-affil=倉敷市立天城小学校 affil-num=13 en-affil= kn-affil=倉敷市立西阿知小学校 affil-num=14 en-affil= kn-affil=倉敷市立西阿知小学校 affil-num=15 en-affil= kn-affil=倉敷市立西阿知小学校 affil-num=16 en-affil= kn-affil=倉敷市立倉敷南小学校 affil-num=17 en-affil= kn-affil=倉敷市立中島小学校 affil-num=18 en-affil= kn-affil=倉敷市立中島小学校 affil-num=19 en-affil= kn-affil=倉敷市立葦高小学校 affil-num=20 en-affil= kn-affil=倉敷市立葦高小学校 affil-num=21 en-affil= kn-affil=倉敷市立旭丘小学校 affil-num=22 en-affil= kn-affil=倉敷市立旭丘小学校 affil-num=23 en-affil= kn-affil=倉敷市立倉敷支援学校 affil-num=24 en-affil= kn-affil=倉敷市立倉敷支援学校 affil-num=25 en-affil= kn-affil=倉敷市立倉敷支援学校 affil-num=26 en-affil= kn-affil=倉敷市立倉敷支援学校 affil-num=27 en-affil= kn-affil=倉敷市立葦高小学校 affil-num=28 en-affil= kn-affil=倉敷市立老松小学校 affil-num=29 en-affil= kn-affil=岡山大学大学院教育学研究科 affil-num=30 en-affil= kn-affil=くらしき作陽大学こども教育学部 en-keyword=小学校 kn-keyword=小学校 en-keyword=健康教育 kn-keyword=健康教育 en-keyword=喫煙・飲酒・薬物乱用防止教育 kn-keyword=喫煙・飲酒・薬物乱用防止教育 en-keyword=養護教諭 kn-keyword=養護教諭 en-keyword=中核的役割 kn-keyword=中核的役割 END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=52 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Consideration of Chorus Activities of a Junior High School in Okayama Prefecture kn-title=岡山県の中学校における合唱活動に関する考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本研究は，岡山県の中学校教育における合唱活動の現状と，その課題点を明らかにすることを目的とする。そ のために，学習指導要領の分析，合唱連盟の加盟団体数及びNHK 全国学校音楽コンクールへの参加校数の他県 との比較，県内中学校の音楽科教員へのインタビュー調査を行った。その結果，①岡山県は合唱指導を得意とす る教員が少なく，音楽の授業や合唱・歌唱指導の内容に差が生じていること②指導者不足により，合唱部の活動 が衰退していること③現場の教員は生徒指導に多くの時間を割かなければならず，授業や部活動に力を入れにく いことが明らかになった。 en-copyright= kn-copyright= en-aut-name=TakahashiAkiko en-aut-sei=Takahashi en-aut-mei=Akiko kn-aut-name=高橋安喜子 kn-aut-sei=高橋 kn-aut-mei=安喜子 aut-affil-num=1 ORCID= en-aut-name=MushiakiMasako en-aut-sei=Mushiaki en-aut-mei=Masako kn-aut-name=虫明眞砂子 kn-aut-sei=虫明 kn-aut-mei=眞砂子 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=倉敷市立水島中学校 affil-num=2 en-affil= kn-affil=岡山大学大学院教育学研究科 en-keyword=岡山県 kn-keyword=岡山県 en-keyword=合唱活動 kn-keyword=合唱活動 en-keyword=中学校教育 kn-keyword=中学校教育 en-keyword=合唱部 kn-keyword=合唱部 en-keyword=NHK 全国学校音楽コンクール kn-keyword=NHK 全国学校音楽コンクール END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=4 article-no= start-page=165 end-page=188 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690326 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Microaerological investigations of the lowest few hundred meters of the atmosphere kn-title=水島における係留気球観測 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakasuK. en-aut-sei=Takasu en-aut-mei=K. kn-aut-name=高須謙一 kn-aut-sei=高須 kn-aut-mei=謙一 aut-affil-num=1 ORCID= en-aut-name=SeoT. en-aut-sei=Seo en-aut-mei=T. kn-aut-name=瀬尾琢郎 kn-aut-sei=瀬尾 kn-aut-mei=琢郎 aut-affil-num=2 ORCID= en-aut-name=YamaguchiN. en-aut-sei=Yamaguchi en-aut-mei=N. kn-aut-name=山口信之 kn-aut-sei=山口 kn-aut-mei=信之 aut-affil-num=3 ORCID= en-aut-name=OhtakiE. en-aut-sei=Ohtaki en-aut-mei=E. kn-aut-name=大滝英治 kn-aut-sei=大滝 kn-aut-mei=英治 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=20 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of Fiber Crops as Adsorption Materials for Cesium and Strontium Ions kn-title=植物繊維類のセシウム及びストロンチウムイオン吸着能評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After the accident of atomic power plants in Fukushima, Japan, the removal of radioactive materials released to environment is most important task and rapid response to the severe problem is required. It is well known that various biomass have adsorption ability for toxic metal ions from aqueous media. We have evaluated the adsorption ability of many fiber crops for cesium and strontium ions. As the results, several fiber crops have considerable ability for the adsorption of such metal ions and are useful for a water and soil purification system in large scale. en-copyright= kn-copyright= en-aut-name=IshikawaTeruhiko en-aut-sei=Ishikawa en-aut-mei=Teruhiko kn-aut-name=石川彰彦 kn-aut-sei=石川 kn-aut-mei=彰彦 aut-affil-num=1 ORCID= en-aut-name=IshimotoAya en-aut-sei=Ishimoto en-aut-mei=Aya kn-aut-name=石本彩 kn-aut-sei=石本 kn-aut-mei=彩 aut-affil-num=2 ORCID= en-aut-name=MizushimaShiho en-aut-sei=Mizushima en-aut-mei=Shiho kn-aut-name=水島志穂 kn-aut-sei=水島 kn-aut-mei=志穂 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科 affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= en-keyword=cesium kn-keyword=cesium en-keyword=strontium kn-keyword=strontium en-keyword=adsorption kn-keyword=adsorption en-keyword=radioactivity kn-keyword=radioactivity en-keyword=fiber crops kn-keyword=fiber crops END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=4 article-no= start-page=329 end-page=334 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of Taurine on Acinar Cell Apoptosis and Pancreatic Fibrosis in Dibutyltin Dichloride-induced Chronic Pancreatitis en-subtitle= kn-subtitle= en-abstract= kn-abstract=The relationship between pancreatic fibrosis and apoptosis of pancreatic acinar cells has not been fully elucidated. We reported that taurine had an anti-fibrotic effect in a dibutyltin dichloride (DBTC)-chronic pancreatitis model. However, the effect of taurine on apoptosis of pancreatic acinar cells is still unclear. Therefore, we examined apoptosis in DBTC-chronic pancreatitis and in the AR42J pancreatic acinar cell line with/without taurine. Pancreatic fibrosis was induced by a single administration of DBTC. Rats were fed a taurine-containing diet or a normal diet and were sacrificed at day 5. The AR42J pancreatic acinar cell line was incubated with/without DBTC with taurine chloramines. Apoptosis was determined by using terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay. The expression of Bad and Bcl-2 proteins in the AR42J cells lysates was detected by Western blot analysis. The apoptotic index of pancreatic acinar cells in DBTC-administered rats was significantly increased. Taurine treatment inhibited pancreatic fibrosis and apoptosis of acinar cells induced by DBTC. The number of TUNEL-positive cells in the AR42J pancreatic acinar cell lines was significantly increased by the addition of DBTC. Incubation with taurine chloramines ameliorated these changes. In conclusion, taurine inhibits apoptosis of pancreatic acinar cells and pancreatitis in experimental chronic pancreatitis. en-copyright= kn-copyright= en-aut-name=MatsushitaKoki en-aut-sei=Matsushita en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShirahigeAkinori en-aut-sei=Shirahige en-aut-mei=Akinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaniokaHiroaki en-aut-sei=Tanioka en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SawaKiminari en-aut-sei=Sawa en-aut-mei=Kiminari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=apoptosis kn-keyword=apoptosis en-keyword=chronic pancreatitis kn-keyword=chronic pancreatitis en-keyword=pancreatic acinar cells kn-keyword=pancreatic acinar cells en-keyword=taurine kn-keyword=taurine END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=3 article-no= start-page=239 end-page=244 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=New Large Bowel Segmentation on Plain Abdominal Radiography in Comparison with the Conventional Method en-subtitle= kn-subtitle= en-abstract= kn-abstract=Plain abdominal radiography is a very basic examination and plays an important role in primary care. The objectives of this study were to clarify colon distributions on plain abdominal radiographs. Forty-three healthy volunteers underwent gastric fluoroscopy, and 2 hours later, plain abdominal radiography in the supine position. A region of interest (ROI) was defined uniformly on each X-ray image to divide the image into 600 zones. The area corresponding to the large bowel within the ROI was divided into 4 segments (ascending colon, transverse colon, descending colon, and sigmoid colon＋rectum). The percentage of barium in each segment relative to the total volume of barium used was calculated to evaluate the percent ROI occupancy. The large bowel covered 76.7% of the entire ROI, with the percent duplication being 55%. The duplicated area corresponded to the transverse colon region. When the method proposed by Arhan et al. was used, the percentage of the colon actually present in each segment relative to that determined theoretically was 99.6% for the right colon segment, 92.2% for the left colon segment, and 92.2% for the sigmoid/rectal segment. However, in cases in which the transverse colon descended partially from the fifth lumbar vertebra, the percentage occupied by the sigmoid colon＋rectum decreased to 57.2%. We applied a new large bowel segmentation method especially for patients with ptosis, by devising a line joining the lateral side of the right lesser pelvis and the lower ends of both sacroiliac joints. en-copyright= kn-copyright= en-aut-name=SawaKiminari en-aut-sei=Sawa en-aut-mei=Kiminari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsushitaKoki en-aut-sei=Matsushita en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShirahigeAkinori en-aut-sei=Shirahige en-aut-mei=Akinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=2 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=3 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=4 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=5 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine affil-num=6 en-affil= kn-affil=Central Clinical Laboratory of Medicine, Okayama University Graduate School of Medicine en-keyword=large bowel kn-keyword=large bowel en-keyword=segmentation kn-keyword=segmentation en-keyword=plain abdominal radiograph kn-keyword=plain abdominal radiograph en-keyword=classification method kn-keyword=classification method en-keyword=primary care kn-keyword=primary care END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=249 end-page=250 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=水島中央病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中務治重 kn-aut-sei=中務 kn-aut-mei=治重 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=247 end-page=248 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=総合病院水島協同病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=里見和彦 kn-aut-sei=里見 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=1 cd-vols= no-issue=2 article-no= start-page=24 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Regional Development and Local Railroad kn-title=地域開発と鉄道経営（I）―水島鉄道について― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakeshitaS. en-aut-sei=Takeshita en-aut-mei=S. kn-aut-name=竹下昌三 kn-aut-sei=竹下 kn-aut-mei=昌三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue=3 article-no= start-page=54 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19701130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Regional Development and Local Railroad kn-title=地域開発と鉄道経営（II）―水島鉄道について― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakeshitaS. en-aut-sei=Takeshita en-aut-mei=S. kn-aut-name=竹下昌三 kn-aut-sei=竹下 kn-aut-mei=昌三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue=1 article-no= start-page=1 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730715 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Industrial Location and Regional Development kn-title=産業立地と地域開発―水島の場合について― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakeshitaS. en-aut-sei=Takeshita en-aut-mei=S. kn-aut-name=竹下昌三 kn-aut-sei=竹下 kn-aut-mei=昌三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=22 cd-vols= no-issue=3-4 article-no= start-page=111 end-page=124 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Petroleum and Chemical Industries in Mizushima Industrial Complex kn-title=水島における石油精製業と化学工業 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShimonoKatsumi en-aut-sei=Shimono en-aut-mei=Katsumi kn-aut-name=下野克已 kn-aut-sei=下野 kn-aut-mei=克已 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=6-2 article-no= start-page=3357 end-page=3369 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590515 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Study on Electrolytes Changes in Hypothermia and Effects of Operation on Its Metabolism Part II. Experimental Study of Operative Effects on Electrolytes Changes in Hypothermia kn-title=低体温麻酔および低温下手術における電解質の変動に関する実験的研究 第2編 低温下手術における電解質の変動に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Effects of operation on seruml evel and urinary excretion of sodium, chloride and potassium, and water and electrolytes coutent in tissue were studied on dogs in both hypothermic and normothermic conditions. Following results were obtained. 1) Hyponatremia and hypochloremia, decrease of urinary excretion of both electrolytes, increase of potassium-sodium ratio and increase of urinary excretion of potassium in accordance with decrease of urine volume were found during postoperative period in dogs who underwent operation under normothermia. However, increase of urine volume occurred on about 5th or 6th postoperative day resulting in increase of urinary excretion of sodium and chloride, and decrease of potassium excretion. Increase of water, sodium and chloride content of the tissue which had operative intervention, were found on the 4th postoperative day, though decrease of potassium was noted. 2) Decrease of serum sodium and chloride, and increase of potassium were noticed in hypothermic group, though these changes were not so significant as in nomothermic group. Urinary excretion of sodium and chloride increased in accordance with increase of urine volume and chloride-sodium ratio were diminished. However, changes after 5th to 6th postoperative day were same in both groups. There were found no significant changes in water and electrolytes content of tissue, which had operative intervention, on the 4th postoperative day in hypothermic group. Increase of water, sodium, and chloride in tissue were slight and no decrease of potassium was found. It was anticipated based on these findings that excretion of ADH and function of adrenal gland were suppressed resulting in increase of urinary excretion of sodium and chloride with less retention of water, sodium and chloride in tissue during postoperative period in operation performed under hypothermia. In addition to, decrease of potassium content in tissue was not found, suggesting of less consumption of body protein and suppression of catabolism during postoperaetive period. en-copyright= kn-copyright= en-aut-name=MizushimaMasatoshi en-aut-sei=Mizushima en-aut-mei=Masatoshi kn-aut-name=水島正俊 kn-aut-sei=水島 kn-aut-mei=正俊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=6-2 article-no= start-page=3345 end-page=3356 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590515 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Study on Electrolytes Changes in Hypothermia and Effects of Operation on Its Metabolism Part I. Experimental Study on Electrolytes Changes in Hypotherm kn-title=低体温麻酔および低温下手術における電解質の変動に関する実験的研究 第1編 低体温麻酔における電解質の変動に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Changes in serum and urine electrolytes, sodium and potassium in erythrocytes, water and electrolytes contents in tissue were studied in dogs under hypothermia. Following results were obtained. 1) Changes in serum sodium and calcium are not found, though potassium decreases and chloride increases in hypothermia. 2) No marked changes in sodium and potassium in erythrocytes are found. 3) Urinary excretion of sodium and chloride decrease, while potassium increases. No changes in excretion of calcium are noted. Total amount of electrolytes excreted in urine decrease because urine volume is markedly diminished in hypothermia below 28°C. 4) No significant changes in water content in tissue are found. There is found no changes in sodium of tissue. Chloride in tissue decreases, while potassium in liver increases though no changes are found in other organs. Calcium in tissue remains constant. Decrease of serum potassium and increase of chloride are remarkable changes in electrolytes in hypothermia. It is anticipated that deposition of potassium develops in liver because of decrease of glucose utilization due to low metabolism and decreased consumption of glycogen with resulting glycogen formation from excessive glucose which carries potassium from the extracellular fluid into the cells. Increase of serum chloride is supposed to be due to mobilzation of intracellular chloride into blood and decrease of excretion in urine. en-copyright= kn-copyright= en-aut-name=MizushimaMasatoshi en-aut-sei=Mizushima en-aut-mei=Masatoshi kn-aut-name=水島正俊 kn-aut-sei=水島 kn-aut-mei=正俊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=3-4 article-no= start-page=319 end-page=323 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of cardiac lipoma kn-title=Cardiac Lipomaの一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We reported a case of primary cardiac lipoma in a 74-year-old woman who had a 23-year history of cardiomegaly. The chest roentgenogram showed an enlargement of the cardiac silhouette. The electrocardiogram showed slight abnormalities including mild low voltage of R wave in V6 and flat T wave in V5 and V6. M-mode and cross-sectional echocardiography revealed a low echoic mass which mainly situated between left ventricular posterior wall and the pericardium. The left and right ventricular wall motion was not affected. Computed tomography of the heart revealed a large mass backward of the left ventricle and right side of the right atrium. The attenuation values of the mass ranged around-118HU and was compatible to lipoma. We diagnosed as a lipoma of the heart possibly arising from the pericardium. Computed tomography may be of use for a very specific diagnosis of cardiac lipoma. en-copyright= kn-copyright= en-aut-name=HasuiMasahiro en-aut-sei=Hasui en-aut-mei=Masahiro kn-aut-name=蓮井雅浩 kn-aut-sei=蓮井 kn-aut-mei=雅浩 aut-affil-num=1 ORCID= en-aut-name=MukouharaNaoki en-aut-sei=Mukouhara en-aut-mei=Naoki kn-aut-name=向原直木 kn-aut-sei=向原 kn-aut-mei=直木 aut-affil-num=2 ORCID= en-aut-name=MarutaniMorio en-aut-sei=Marutani en-aut-mei=Morio kn-aut-name=丸谷盛雄 kn-aut-sei=丸谷 kn-aut-mei=盛雄 aut-affil-num=3 ORCID= en-aut-name=OhbayashiNaotsugu en-aut-sei=Ohbayashi en-aut-mei=Naotsugu kn-aut-name=大林直嗣 kn-aut-sei=大林 kn-aut-mei=直嗣 aut-affil-num=4 ORCID= en-aut-name=ShrakiTeruo en-aut-sei=Shraki en-aut-mei=Teruo kn-aut-name=白木照夫 kn-aut-sei=白木 kn-aut-mei=照夫 aut-affil-num=5 ORCID= en-aut-name=UchidaShinji en-aut-sei=Uchida en-aut-mei=Shinji kn-aut-name=内田真司 kn-aut-sei=内田 kn-aut-mei=真司 aut-affil-num=6 ORCID= en-aut-name=IharaKeiko en-aut-sei=Ihara en-aut-mei=Keiko kn-aut-name=井原敬子 kn-aut-sei=井原 kn-aut-mei=敬子 aut-affil-num=7 ORCID= en-aut-name=TogawaJun-ichiro en-aut-sei=Togawa en-aut-mei=Jun-ichiro kn-aut-name=戸川潤一郎 kn-aut-sei=戸川 kn-aut-mei=潤一郎 aut-affil-num=8 ORCID= en-aut-name=YamanariHiroshi en-aut-sei=Yamanari en-aut-mei=Hiroshi kn-aut-name=山成洋 kn-aut-sei=山成 kn-aut-mei=洋 aut-affil-num=9 ORCID= en-aut-name=HinaKazuyoshi en-aut-sei=Hina en-aut-mei=Kazuyoshi kn-aut-name=日名一誠 kn-aut-sei=日名 kn-aut-mei=一誠 aut-affil-num=10 ORCID= en-aut-name=KusachiShozo en-aut-sei=Kusachi en-aut-mei=Shozo kn-aut-name=草地省蔵 kn-aut-sei=草地 kn-aut-mei=省蔵 aut-affil-num=11 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=12 ORCID= en-aut-name=MimaTsutomu en-aut-sei=Mima en-aut-mei=Tsutomu kn-aut-name=美馬敦 kn-aut-sei=美馬 kn-aut-mei=敦 aut-affil-num=13 ORCID= en-aut-name=MatsubaraKatashi en-aut-sei=Matsubara en-aut-mei=Katashi kn-aut-name=松原堅 kn-aut-sei=松原 kn-aut-mei=堅 aut-affil-num=14 ORCID= en-aut-name=SaitoDaiji en-aut-sei=Saito en-aut-mei=Daiji kn-aut-name=斎藤大治 kn-aut-sei=斎藤 kn-aut-mei=大治 aut-affil-num=15 ORCID= en-aut-name=HaraokaShoichi en-aut-sei=Haraoka en-aut-mei=Shoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=16 ORCID= en-aut-name=TaniHideki en-aut-sei=Tani en-aut-mei=Hideki kn-aut-name=谷秀樹 kn-aut-sei=谷 kn-aut-mei=秀樹 aut-affil-num=17 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=13 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=14 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=15 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=16 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=17 en-affil= kn-affil=川崎製鉄水島病院内科 en-keyword=Cardiac lipoma kn-keyword=Cardiac lipoma en-keyword=胸部CT kn-keyword=胸部CT en-keyword=心エコー kn-keyword=心エコー END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=3 article-no= start-page=231 end-page=236 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of transverse colon cancer with remarkable extramural invasion to stomach and jejunum kn-title=壁外性に腫瘤を形成し胃・小腸浸潤を示した横行結腸癌の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 77-year-old woman was admitted to our hospital due to abdominal pain and body weight loss. A palpable mass the size of an infant's head was tender on palpation and identified as an epigastric lesion. Colonoscopic examination revealed stenosis of the transverse colon, although no intraluminal growth of the tumor was found. The histologic findings of the biopsy material were poorly differentiated and/or undifferentiated cells. Abdominal CT scan showed an irregular-shaped tumor with a diameter of 10cm invading the stomach and jejunum. We performed an operation under a diagnosis of extramurally growing cancer or malignant lymphoma of the colon. Partial resection of the transverse colon was done by distal gastrectomy and partial resection of the jejunum. Histologic examination of the operative specimens revealed moderately differentiated adenocarcinoma of the transverse colon, prominently proliferating into the surrounding tissues. The finding of a long stenotic lesion and extramural compression by colonography are characteristic of this tumor, based on a review of 43 literature reports in Japan. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=2 ORCID= en-aut-name=KimuraYuuji en-aut-sei=Kimura en-aut-mei=Yuuji kn-aut-name=木村裕司 kn-aut-sei=木村 kn-aut-mei=裕司 aut-affil-num=3 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=4 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=5 ORCID= en-aut-name=MiyasouHideaki en-aut-sei=Miyasou en-aut-mei=Hideaki kn-aut-name=宮宗秀明 kn-aut-sei=宮宗 kn-aut-mei=秀明 aut-affil-num=6 ORCID= en-aut-name=TsunemituYousuke en-aut-sei=Tsunemitu en-aut-mei=Yousuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=7 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=8 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=9 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=10 en-affil= kn-affil=国立病院機構福山医療センター　外科 en-keyword=大腸癌 (colon cancer) kn-keyword=大腸癌 (colon cancer) en-keyword=壁外性発育 (extraluminal growth) kn-keyword=壁外性発育 (extraluminal growth) END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=3 article-no= start-page=135 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Analysis of HCV genotypes from blood donors shows three new HCV type 6 subgroups exist in Myanmar. en-subtitle= kn-subtitle= en-abstract= kn-abstract=The prevalence of hepatitis C virus (HCV) genotypes in Myanmar in comparison with the rest of Southeast Asia is not well known. Serum samples were obtained from 201 HCV antibody-positive volunteer blood donors in and around the Myanmar city of Yangon. Of these, the antibody titers of 101 samples were checked by serial dilution using HCV antibody PA test II and Terasaki microplate as a low-cost method. To compare antibody titers by this method and RNA identification, we also checked HCV-RNA using the Amplicor 2.0 test. Most high-titer groups were positive for HCV-RNA. Of the 201 samples, 110 were successfully polymerase chain reaction (PCR) amplified. Among them, 35 (31.8%) were of genotype 1, 52 (47.3%) were of genotype 3, and 23 (20.9%) were of type 6 variants, and phylogenetic analysis of these type 6 variants revealed that 3 new type 6 subgroups exist in Myanmar. We named the subgroups M6-1, M6-2, and M6-3. M6-1 and M6-2 were relatively close to types 8 and 9, respectively. M6-3, though only found in one sample, was a brand-new subgroup. These subtypes were not seen in Vietnam, where type 6 group variants are widely spread. These findings may be useful for analyzing how and when these subgroups were formed. en-copyright= kn-copyright= en-aut-name=ShinjiToshiyuki en-aut-sei=Shinji en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KyawYi Yi en-aut-sei=Kyaw en-aut-mei=Yi Yi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=GokanKatsunori en-aut-sei=Gokan en-aut-mei=Katsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaYasuhito en-aut-sei=Tanaka en-aut-mei=Yasuhito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KusanoNobuchika en-aut-sei=Kusano en-aut-mei=Nobuchika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujiokaShin-ichi en-aut-sei=Fujioka en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=LwinAye Aye en-aut-sei=Lwin en-aut-mei=Aye Aye kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ShiratoriYasushi en-aut-sei=Shiratori en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MizokamiMasashi en-aut-sei=Mizokami en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KhinMyo en-aut-sei=Khin en-aut-mei=Myo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MiyaharaMasayuki en-aut-sei=Miyahara en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=OkadaShigeru en-aut-sei=Okada en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Lower Myanmar affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Nagoya City University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University affil-num=10 en-affil= kn-affil=Okayama University affil-num=11 en-affil= kn-affil=Okayama University affil-num=12 en-affil= kn-affil=Nagoya City University affil-num=13 en-affil= kn-affil=Medical Research(Lower Myanmar) affil-num=14 en-affil= kn-affil=Okayama Red Cross Blood Center affil-num=15 en-affil= kn-affil=Okayama University affil-num=16 en-affil= kn-affil=Okayama University en-keyword=hepatitis C virus(HCV)genotype kn-keyword=hepatitis C virus(HCV)genotype en-keyword=type 6 variant kn-keyword=type 6 variant en-keyword=Myanmar kn-keyword=Myanmar en-keyword=Southeast Asia kn-keyword=Southeast Asia en-keyword=phylogenetic analysis kn-keyword=phylogenetic analysis END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=1 article-no= start-page=55 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Gastrobiliary Dysmotility in Patients with Chronic Pancreatitis as Assessed by a Single Noninvasive Test en-subtitle= kn-subtitle= en-abstract= kn-abstract=We simultaneously assessed gastric emptying and gallbladder contraction after oral administration of a liquid meal by noninvasive ultrasonography in 17 patients with chronic pancreatitis (CP) and in 17 healthy controls. Gastrointestinal (GI) transit was also assessed by a noninvasive radioopaque marker method. Exocrine pancreatic function was evaluated by analyzing pure pancreatic juice and by analyzing the autonomic nervous system by cardiovascular reflex tests. Patients with CP showed impaired gallbladder contraction at 15 min and hastened gastric emptying. The cause of the former is unclear, whereas the latter was closely related with decreased pancreatic lipase output, but not with autonomic dysfunction. GI transit time did not differ between controls and patients with CP. In conclusion, we succeeded in clearly demonstrating impaired gallbladder contraction and hastened gastric emptying in patients with CP by a single noninvasive test, ultrasonography. We also revealed for the first time that hastened gastric emptying is associated with insufficient pancreatic lipase output. en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=chronic pancreatits kn-keyword=chronic pancreatits en-keyword=gastric emptying kn-keyword=gastric emptying en-keyword=gallbladder motility kn-keyword=gallbladder motility en-keyword=colonic transit kn-keyword=colonic transit en-keyword=lipase output kn-keyword=lipase output END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=11 article-no= start-page=3999 end-page=4002 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Helminthiasis at Mizushima, the Southern Part of Kurashiki City, Okayama Prefecture. (2) Clonorchiasis Sinensis kn-title=岡山県倉敷市水島およびその周辺地区の寄生虫病について（2）肝吸虫症 en-subtitle= kn-subtitle= en-abstract= kn-abstract=From an investigation into the distribution and symptomatology of Clonorchiasis sinensis at Mizushima, the southern part of Kurashiki City, the following results have been obtained. 1) The majority of cases occurred in adult Koreans, and only few cases in Japanese. 2) The vectors concerned in this area are mainly Carassius auratus and Cyprinus carpio. 3) Serious cases were found very often. en-copyright= kn-copyright= en-aut-name=MizuotiOsamu en-aut-sei=Mizuoti en-aut-mei=Osamu kn-aut-name=水落理 kn-aut-sei=水落 kn-aut-mei=理 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部寄生虫学教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=11 article-no= start-page=3993 end-page=3998 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19581130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Helminthiasis at Mizushima, the Southern Part of Kurashiki City, Okayama Prefecture. (1) Ascariasis and Ancylostomiasis kn-title=岡山県倉敷市水島およびその周辺地区の寄生虫病について（1）蛔虫症および鈎虫症 en-subtitle= kn-subtitle= en-abstract= kn-abstract=As a result of epidemiological survey of Ascariasis and Ancylostomiasis at Mizushima, the southern part of Kurashiki City, the following findings were made. 1) Ascariasis occurs more frequently among the Koreans than among the Japanese. 2) The incidence of Ascariasis is decreasing in the Japanese, but increasing or static in the Koreans depending on their standard of living. 3) The incidence of Ancylostomiasis might be gradually increasing in this area, though any difference by race or living quarter could not be ascertained. en-copyright= kn-copyright= en-aut-name=MizuotiOsamu en-aut-sei=Mizuoti en-aut-mei=Osamu kn-aut-name=水落理 kn-aut-sei=水落 kn-aut-mei=理 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部寄生虫学教室 END start-ver=1.4 cd-journal=joma no-vol=84 cd-vols= no-issue=7-8 article-no= start-page=201 end-page=207 dt-received= dt-revised= dt-accepted= dt-pub-year=1972 dt-pub=19720830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relationship between Sulfur Dioxide Concentration in Mizushima Industrial Area Part 2〔Comparison of Sulfur Dioxide Concentration Measured Practically and Logical Concentration Calculated Using Pasquill's Chart〕 kn-title=水島臨海工業地帯における大気汚染と気象条件について 第2報 オートレコーダーで実測された亜硫酸ガス濃度と理論拡散計算値との関係について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author calculated, using Pasquill's chart, the logical concentration of sulfur dioxide concerning principal 15 chimneys in many places of Mizushima industrial area which had emitted 74 percent sulfur dioxide over Mizushima, and compared concentrations measured practically at the respective station of Fukuda-cho, Mizushima Harbor Office and Amagi with the logical concentration calculated by Pasquill's chart. The results obtained were as follows. 1. The high concentrations of sulfur dioxide measured practically at Fukuda-cho station could be logically explained by the diffusion called C-stability following Pasquill, and those at Amagi station could be also explained by the diffusion called D-stability. 2. Under the condition of each of A and B stabilities following Pasquill, sulfur dioxide diffused itself significantly on C-stability in Pasquill's chart, and in the case of each B and C stabilities, it diffused itself on D-stability in Pasquill's chart. en-copyright= kn-copyright= en-aut-name=InoueKentaro en-aut-sei=Inoue en-aut-mei=Kentaro kn-aut-name=井上堅太郎 kn-aut-sei=井上 kn-aut-mei=堅太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=81 cd-vols= no-issue=3-4 article-no= start-page=193 end-page=197 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Abnormal Odor Fish by Oil Pollution in Mizusima Industrial Area. Part 1. Distribution of Abnormal Odor Fish kn-title=水島地区の水質汚濁,特に異臭魚の発生に関する研究 第1報 異臭魚の分布状況について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The distribution of abnormal odor fish owing to industrial waste water from oil or its combinative industrial factories around the Miziushia waters was surveyed and the followings were obtained as the result. 1) It was found that almost all of abnormal odor fishes in the Migushima waters grow around the Mizushima harbour where many exits of industrial waste water from factories are gathered. The area of the distribution is beconing more extensive with the degree of 1 or 2 Km. every year, and it has stretched 8 Km. to the south and 12 Km. to the west around the Mizushima harbour. 2) Fishes having the high swimmung activity (ex. common sea-bass, gizzard shad and gray mullet etc.) were found as abnormal odor fishes as far as the border of the distribution area, and fishes having the low activity (ex. rock, bleak sea-bream and surf-fish etc.) were found within 1 Km. from the mouth of the harbour. And the following is thinkable that fishes gather to the warm water of the Mizushima harbour owing to the high temperature of waste water of factaries and there become abnormal odor fishes, and in spring when water becomes warm, they scatter away from the harbour. en-copyright= kn-copyright= en-aut-name=MiyakeYoshio en-aut-sei=Miyake en-aut-mei=Yoshio kn-aut-name=三宅与志雄 kn-aut-sei=三宅 kn-aut-mei=与志雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=81 cd-vols= no-issue=3-4 article-no= start-page=127 end-page=134 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relationship between Sulfur Dioxide Concentration and Meteorological Condition in Mizushima Industrial DistrictReport 1 (Relationship among Sulfur Dioxide Concentration and Wind Derection, Wind Velocity and Atmospheric Stability) kn-title=水島臨海工業地帯における大気汚染と気象条件について 第1報 亜硫酸ガス濃度と風向，風速，大気安定度との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author calculated the frequency of high concentration of sulfur dioxide (over 0.2 p. p. m.) in one hour according to wind direction, wind velocity and Pasquill's stability, and the author also calculated the average concentration of sulfur dioxide according to wind direction and velocity. The results obtained were as follows; 1. S, SSW, SW, and WSW winds (mainly sea breeze) bring the air pollutant to the northern part in Mizushima Industrial Area. Wind direction and wind velocity that brings. a higher concentration of sulfur dioxide to Fukuda-cho, Minami Kasuga-cho, and Amagi were S, SW, and SSW winds of 3～4 M/sec. In Mizushima Harbour Office, high sulfur dioxide concentartions were measured in S, SW, 2～3 M/sec. and SW, 2～5 M/sec. Average sulfur dioxide concentrations were higher in S, SW, 2～4 M/sec. in Fukuda-cho, Minami Kasuga-cho and higher in SSE 6 M/sec., SSW 6～7 M/sec., SW 2～5 M/sec., and S 3 M/sec. in Mizushima Harbour Office. 2. Unstable sea breeze brings higher concentrations of sulfur dioxide to Fukuda-cho and more stable sea breeze brings higher concentrations to Amagi. From the calculations of diffusion by Pasquill's chart it was shown that the diffusion in C-stability brings high concentrations of sulfur dioxide to Fukuda-cho, and the diffusion in D-stability brings to Amagi. en-copyright= kn-copyright= en-aut-name=InoueKentaro en-aut-sei=Inoue en-aut-mei=Kentaro kn-aut-name=井上堅太郎 kn-aut-sei=井上 kn-aut-mei=堅太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=81 cd-vols= no-issue=1-2 article-no= start-page=9 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Hygienic Study on Water Pollution by Industrial Progress at Port Mizushima Part Ⅱ A Device of Triangle Co-ordinates as a Method for Evaluation of the Water Pollution kn-title=臨海工業地帯開発に伴う水島港海水の衛生学的調査研究 第Ⅱ報 三角座標による海水汚染の評価に関する考案 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Port Mizushima has been artificially modified during the development of industries. The shape is long and narrow like a canal where no stream ispouring into. The pollution of sea water of the port was investigated for six years and the results were reported in Peport (1). In this report, the auther has devised a method to evaluate the degree of the sea pollution using a system of triangle co-ordinates. The first axis (X) shows places, the second (Y) years and the third (Z) degrees of pollution expressed by disorbed oxygen (DO), chemical oxygen demand (COD). biochemical oxygen demand (BOD) and iodine consumptions. This device has been proved possible to evaluate the degree of pollution simultaneously concerning places, laps of years. He has shown the changing patterns of the sea pollution at Port Mizushima as a whole using this triangle co-ordinates. en-copyright= kn-copyright= en-aut-name=MaruyaHiroshi en-aut-sei=Maruya en-aut-mei=Hiroshi kn-aut-name=丸屋博 kn-aut-sei=丸屋 kn-aut-mei=博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=81 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Hygienic Study on Water Pollution by Industrial Progress at Port Mizushima Part Ⅰ The Actual Status of the Pollution kn-title=臨海工業地帯開発に伴う水島港海水の衛生学的調査研究（第1報）水島港に於ける海水汚染の実態 en-subtitle= kn-subtitle= en-abstract= kn-abstract=At Port Mizushima in Okayama Prefecture as a center of an heavy industrial area in the Seto Inland Sea, many factories have been built and more are in construction for the future progress. This industrial progress has brought water pollution which is one of the public nuisances, a serious problem from the stand point of public health. The anther has investigated the actual feature of the pollution of sea water in this port for six years. The results ware as follows: (1) Water at this port area has been polluted year by year during last six years. (2) The degree of the pollution changes by places: at the innermost the most serious and the entrance the least. (3) At the low-tide water was more polluted than high-water.(4) Industrial wastes were investigated and some of them were out of hygienic criteria. en-copyright= kn-copyright= en-aut-name=MaruyaHiroshi en-aut-sei=Maruya en-aut-mei=Hiroshi kn-aut-name=丸屋博 kn-aut-sei=丸屋 kn-aut-mei=博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=83 cd-vols= no-issue=5-6 article-no= start-page=157 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=1971 dt-pub=19710630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Abnormal Odor Fish by Oil Pollution in Mizushima Industrial Area. Part 2. Degree of Offensive Odor of Decoy Eels cultured in Sea Water along Mizushima Industrial Area and Analysis of their Offensive Odor Substance by Gas Chromatography kn-title=水島地区の水質汚濁,特に異臭魚の発生に関する研究 第2報 水島地区の海水中に設置したおとりうなぎの着臭度及び異臭成分のガスクロマトグラフ分析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The degree of offensive odor of decoyed eels cultured in the sea water along Mizushima industrial area was studied and offensive odor substance in decoyed eels was analyzed by gas chromatography. The results obtained were as follows. Ninety percent of decoyed eels changed into offensive odor eels when cultured in the sea water within a distance of 1km. from the exit of industrial waste. Offensive odor of decoyed eels is similar to that of offensive odor fish caught in this sea and new peak considerd to be offensive odor substances was revealed in gas chromatogram with gas evaporated from offensive odor eels. This new peak is corresponded to tha peak with sea water and that with industrial waste. Degree of offensive odor and also offensive odor peak in gas chromatogram were scarcely found in the eels cultured in the sea at a very distanee of about 1Km. from the harbor. From decoyed eels or odor-substances in the sea-water, it was recognized that fishes which had lived north in Mizushima harbors became gradually evil-odor fishes in various degrees corre sponding to degree of odorness and quantity of odor-substances in the sea-water. en-copyright= kn-copyright= en-aut-name=MiyakeYoshio en-aut-sei=Miyake en-aut-mei=Yoshio kn-aut-name=三宅与志雄 kn-aut-sei=三宅 kn-aut-mei=与志雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=3-4 article-no= start-page=497 end-page=504 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relationship between air pollution and meteorological conditions in Mizushima Industrial Area Report 3 (Air pollution of nitrogen monooxide and nitrogen dioxide monitored by auto recorder) kn-title=水島臨海工業地帯における大気汚染と気象条件について 第3報 自動測定機で測定された窒素酸化物汚染の特徴について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author analysed the air pollution data of NO, NO(2) and NO(x) (NO+NO(2)) measured by auto recorder in Mizushima. The results obtained were as follows. 1) NO(x) exhausted from factories in Mizushima Industrial District are carried by sea breeze (wind S-WSW, 1-6m/sec.) and pollutes northern area of Mizushima as same as SO(x). The sea breeze bings the NO(x) exhausted from factories to Matsue, closed to factories, Fukuda, about 3km from factories, and also Kurashiki and Amagi, far from factories, as same as SO(x). 2) NO(x) exhausted from cars is not negligible at four monitoring stations analysed, especially at Kurashiki. en-copyright= kn-copyright= en-aut-name=InoueKentaro en-aut-sei=Inoue en-aut-mei=Kentaro kn-aut-name=井上堅太郎 kn-aut-sei=井上 kn-aut-mei=堅太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=7-8 article-no= start-page=701 end-page=708 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Multiple polypoid filling defects of the duodenal bulb kn-title=十二指腸球部多発陰影欠損について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Multiple polypoid filling defects of the duodenal bulb are infrequently encountered. Two cases of multiple filling defects of the duodenal bulb are reported in this paper. Case 1. A 42 year old female complained of abdominal fullness and epigastralgia. On examination, generalized peripheral lymphadenopathy and marked hepatosplenomegaly were noted. Cervical lymphnode biopsy revealed a diffuse, poorly-differanciated lymphocytic lymphoma. X-ray examination of the gastrointestinal tract showed multiple filling defects localized at the duodenal bulb. Endoscopy disclosed multiple well-defined protrusions with small mucosal ulceration over the the whole circumference of the duodenal wall. Case 2. A 36 year old female had no subjective symptoms. At gastric mass screening, numerous polypoid elevations of the duodenal bulb were pointed out. Detailed gastrointestinal x-ray examination showed numerous, tiny, round polypoid nodules localized at the duodenal bulb. These nodules were 2-3mm in size with no mucosal ulceration. The endoscopic biopsy specimen revealed lymphoid hyperplasia of the duodenal bulb. en-copyright= kn-copyright= en-aut-name=MorinoYasuo en-aut-sei=Morino en-aut-mei=Yasuo kn-aut-name=森野靖雄 kn-aut-sei=森野 kn-aut-mei=靖雄 aut-affil-num=1 ORCID= en-aut-name=TakedaYoshihiro en-aut-sei=Takeda en-aut-mei=Yoshihiro kn-aut-name=竹田芳弘 kn-aut-sei=竹田 kn-aut-mei=芳弘 aut-affil-num=2 ORCID= en-aut-name=MorimotoSetsuo en-aut-sei=Morimoto en-aut-mei=Setsuo kn-aut-name=森本節夫 kn-aut-sei=森本 kn-aut-mei=節夫 aut-affil-num=3 ORCID= en-aut-name=MiyakeMasayoshi en-aut-sei=Miyake en-aut-mei=Masayoshi kn-aut-name=三宅正淑 kn-aut-sei=三宅 kn-aut-mei=正淑 aut-affil-num=4 ORCID= en-aut-name=HayashiHidehiro en-aut-sei=Hayashi en-aut-mei=Hidehiro kn-aut-name=林英博 kn-aut-sei=林 kn-aut-mei=英博 aut-affil-num=5 ORCID= en-aut-name=EzoeHiroshi en-aut-sei=Ezoe en-aut-mei=Hiroshi kn-aut-name=江添弘 kn-aut-sei=江添 kn-aut-mei=弘 aut-affil-num=6 ORCID= en-aut-name=KimotoShin en-aut-sei=Kimoto en-aut-mei=Shin kn-aut-name=木本真 kn-aut-sei=木本 kn-aut-mei=真 aut-affil-num=7 ORCID= en-aut-name=JojaIkuo en-aut-sei=Joja en-aut-mei=Ikuo kn-aut-name=上者郁夫 kn-aut-sei=上者 kn-aut-mei=郁夫 aut-affil-num=8 ORCID= en-aut-name=HashimotoKeiji en-aut-sei=Hashimoto en-aut-mei=Keiji kn-aut-name=橋本啓二 kn-aut-sei=橋本 kn-aut-mei=啓二 aut-affil-num=9 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=10 ORCID= en-aut-name=HayashiKyoichi en-aut-sei=Hayashi en-aut-mei=Kyoichi kn-aut-name=林恭一 kn-aut-sei=林 kn-aut-mei=恭一 aut-affil-num=11 ORCID= en-aut-name=TakaokaKazuko en-aut-sei=Takaoka en-aut-mei=Kazuko kn-aut-name=高岡和子 kn-aut-sei=高岡 kn-aut-mei=和子 aut-affil-num=12 ORCID= en-aut-name=OshimaYukiko en-aut-sei=Oshima en-aut-mei=Yukiko kn-aut-name=大島由起子 kn-aut-sei=大島 kn-aut-mei=由起子 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第II内科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第II内科学教室 affil-num=13 en-affil= kn-affil=三菱水島病院内科 en-keyword=Duodenal bulb kn-keyword=Duodenal bulb en-keyword=multiple polypoid nodules kn-keyword=multiple polypoid nodules END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=65 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagonosis of pancreatic cyst using post-ERCP CT examination. kn-title=ERCP後CTによる膵嚢胞性疾患の診断 en-subtitle= kn-subtitle= en-abstract=Post-ERCP CT (computed tomography (CT) examination performed immediately after endoscopic retrograde cholangiopancreatography) detects the contrast medium injected into the pancreatic duct and cystic lesions at the time of ERCP and, therefore, has the advantage of obtaining information which cannot be obtained by ERCP alone. We have experienced four cases of pancreatic cysts in which post-ERCP CT was useful for diagnosis and in deciding on treatment plans. The post-ERCP CT was proved to be a useful method for examining the site and characteristics of the cysts which communicated with the main pancreatic duct. kn-abstract=ERCP直後にCTを撮影するERCP後CTはERCPの際に膵内に注入された造影剤をCTで検出するため,ERCPでは得られない情報が得られる利点がある｡われわれはERCP後CTが診断や治療方針の決定に有用であった膵嚢胞の4例を経験した｡膵嚢胞では主膵管との連絡,嚢胞の部位,性状診断にERCP後CTは有用な検査法であり,文献的考察を含めて報告した｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoTosinobu en-aut-sei=Seno en-aut-mei=Tosinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=RiazChowdhury kn-aut-sei=Riaz kn-aut-mei=Chowdhury aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=8 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=11 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=12 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 affil-num=9 en-affil= kn-affil=岡山大学三朝分院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=岡山大学三朝分院 affil-num=13 en-affil= kn-affil=勝山病院外科 en-keyword=ERCP (Endoscopic retrograde cholangiopancreatography) kn-keyword=ERCP (Endoscopic retrograde cholangiopancreatography) en-keyword=CT (Computed tomography) kn-keyword=CT (Computed tomography) en-keyword=膵嚢胞 (pancreatic cyst) kn-keyword=膵嚢胞 (pancreatic cyst) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=27 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tropical calcific pancreatitis.........An overview en-subtitle= kn-subtitle= en-abstract=熱帯地方の貧困層の小児や若干成人にみられる非アルコール性の慢性膵炎で,小児期に反復する腹痛で発症し,10～20歳で膵性糖尿病になり,20～ 30歳で死亡する類似の病像を示す症例をTropical calcific pancreatitis(熱帯性石灰化慢性膵炎)という｡高率に膵石を伴う｡成因は乳幼児期からの熱量,蛋白貰,micronutrients(亜鉛,銅,セレニウム)の摂取不足に加えて食事中シアン産生物質や環境中oxidantsなど複合因子によると推測されている｡病理像は世界各国にみられる慢性膵炎典型例に類似する｡最近は,生活環境や医療事情の改善により,全身栄養障害の減少や生存期間 の延長など病像が変貌しっつある｡糖尿病を重視する立場からはFibrocalculous pancreatic diabetesと呼ばれ,同一地域にみられるProtein-deficient pancreatic diabetesと合わせてMalnutrition-related diabetes mellitus(MRDM)と総称し,糖尿病の一亜型に分類されている。 kn-abstract=Tropical calcific pancreatitis is a nonalcoholic type of chronic pancreatitis affecting the childrens and young adults characterized clinically by recurrent abdominal pain in childhood, diabetes in adolescent and death in early childhood. Although the exact etiology is not known, malnutrition and chronic cassava toxicity either singly or in combination are presumed to be the prime factor in pancreatic injury unopposed by detoxification of free radical. Moreover micronutrients deficiency, oxidant stress and antioxidant deficiency might play substantial role. Diabetes secondary to tropical calcific pancreatitis is a distinctive and frequent problem, being named by W.H.O. study group as 'fibrocalculous pancreatic diabetes (FCPD) and classified as one of the variant of the so-called malnutrition related diabetes mellitus (MRDM). en-copyright= kn-copyright= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=3 ORCID= en-aut-name=MatsumotoShooji en-aut-sei=Matsumoto en-aut-mei=Shooji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=4 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 en-keyword=Tropical calcific pancreatitis (TCP) kn-keyword=Tropical calcific pancreatitis (TCP) en-keyword=malnutrition kn-keyword=malnutrition en-keyword=cassava kn-keyword=cassava en-keyword=diabetes kn-keyword=diabetes en-keyword=abdominal pain kn-keyword=abdominal pain END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=22 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study of the preparation with sodium picosulfate and PEG intestinal lavage solution for total colonoscopy. kn-title=Sodium picosulfate,PEG腸管洗浄液併用によるTotal colonoscopyの前処置法に関する検討 en-subtitle= kn-subtitle= en-abstract=The following results were obtained from a total colonoscopic study of 50 patients who received preparation with 20mℓ of sodium picosulfate (Laxoberon®) and PEG intestinal lavage solution (Niflec®) prior to the examination. (l) The present method in combination with a mean of 1230mℓ of PEG intestinal lavage solution allowed colonic cleaning for which observation was available in 48 of 50 patients. (2) With this method. no adverse reactions were observed except for mild abdominal pain, nausea, and rugitus in a few patients. (3) This method was particularly as a preparation for colonoscopic examination in elderly patients. Thus, we conclude that preparation with 20mℓ of sodium picosulfate and PEG intestinal lavage solution is useful for colonoscopic examination. kn-abstract=Total colonoscopyの前処置における被検者の負担軽減と良好な腸管洗浄を得る目的で,50例の大腸内視鏡検査において,前日の食事制限せず, sodium picosulfate 20mℓ前夜服用,検査当日PEG腸管洗浄液1ℓ以上服用する前処置法の有用性について検討した。本前処置法によってPEG腸管洗浄液平均1230mℓの服用により,50例中48例で観察可能な腸管洗浄が得られ,PEG腸管洗浄液の服用量の減量が可能であった｡腹痛,嘔気,腹鳴などの症状出現例は認めたが,重篤な副作用は認めなかった｡腸管洗浄度の点で,高齢者の大腸内視鏡検査の前処置として有用である｡以上よりSodium Picosulfate 20mℓをPEG腸管洗浄液と併用することにより,優れた腸管洗浄度を得られると同時にPEG腸管洗浄液服用量の減量か可能であり,total colonoscopyの前処置として有用であることが示された。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=5 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=6 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=10 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=11 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=12 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学第2内科 affil-num=8 en-affil= kn-affil=岡山大学三朝分院 affil-num=9 en-affil= kn-affil=岡山大学三朝分院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=勝山病院 affil-num=13 en-affil= kn-affil=八幡浜医師会立双岩病院 en-keyword=大腸内視鏡検査 (colonoscopy) kn-keyword=大腸内視鏡検査 (colonoscopy) en-keyword=前処置 (preparation) kn-keyword=前処置 (preparation) END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=85 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Experimental model of chronic pancreatitis, a review - Does it really exist? en-subtitle= kn-subtitle= en-abstract=疾患の実験モデルの作成は,その疾患の病因,病態の解明,さらに治療法の開発のために重要である｡筆者らの一人は厚生省難治性膵疾患調査研究班の班員として,慢性膵炎の病態の解明や治療法の開発に関する研究を行っており,その研究の一環として,慢性膵炎の実験モデルの作成を現在行っている｡そこで,これまで報告されている慢性膵炎の実験モデルについて概要を報告した｡種々の動物や方法でヒト慢性膵炎に病因,病態,組織像が類似するモデルの作成が試みられてきたが,そのすべてが合致するような慢性膵炎モデルは確 立されてはいない｡近年の分子生物学的研究の進歩は著しく,実験モデルへの応用が種々なされている現在,より簡便で再現性のある慢性膵炎モデルの作成が望まれるところである｡ kn-abstract=Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=5 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=6 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=7 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=8 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学第2内科 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue= article-no= start-page=78 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=199509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Collagen degradation and in the pathogenesis of dieseases kn-title=コラーゲン分解系と疾患 en-subtitle= kn-subtitle= en-abstract=Fibrosis is the result of net accumulation of collagen in the organ. This may occur as a consequence of alterations in the synthesis of collagen, their degradation, or both. Recent investigations revealed that a decrease in collagen degradation plays a crucial role in fibrogenesis. Two pathways exist in collagen degradation : extracellular and intracellular. Each pathway has an important enzyme; that is, matrix metalloproteinases (MMP) and collagenolytic cathepsin, respectively. Collagenolytic activity is regulated at several levels. Expression of MMP and tissue inhibitors of metalloproteinase (TIMP), which act as inhibitors of MMP, is regulated independently by a number of cytokines and growth factors. MMP, which is synthesized in the cell, is secreted in a latent form. Activation of the latent MMP is controlled by TIMP and plasminogen activator inhibitor. TIMP also inhibits activated MMP which can degrade connective tissue matrices including collagens. In the condition where TIMP is predominant over MMP, activity of collagen breakdown is reduced, and consequently collagen deposition occurrs. kn-abstract=組織のコラーゲン沈着にはコラーゲン合成系と分解系の不均衡によって生ずる｡従来,主としてコラーゲン合成系が注目されていたが,最近の研究の進歩により,コラーゲン分解系が重要な役割を演ずることが明らかになってきた｡コラーゲンの分解系には細胞内と細胞外の二つの経路が存在する｡それぞれcollagenolytic cathepsinおよびmatrix metalloproteinases( MMP)がコラーゲン分解能を有する重要な酵素である｡その調節因子については細胞外の経路についての解明か進んでいる｡MMPの遺伝子の発現にはサイトカインや成長因子が関与し,IL-1やTNF-αは強力な誘導因子である｡一旦,遺伝子か発現すれば,MMPは合成され,細胞外に不活性型(latent form)で分泌される｡不活性型のMMPが活性化する過程にはplasminogen activator inhibitorやtissue inhibitors of metalloproteinases(TIMP)などの阻害因子が存在し,MMP活性を調節する｡TIMPの遺伝子の発現にもサイトカインや成長因子が関与する｡MMPがTIMPを上回るような病態では組織破壊が,逆にTIMPがMMPを上回るような病態では綿維化が生ずる｡コラーゲン分解能の障害が線維化の維持や不可逆性に関与することが推察される。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=3 ORCID= en-aut-name=YamashitaHaruhiro en-aut-sei=Yamashita en-aut-mei=Haruhiro kn-aut-name=山下晴弘 kn-aut-sei=山下 kn-aut-mei=晴弘 aut-affil-num=4 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=5 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=6 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=7 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=8 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学第2内科 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 affil-num=12 en-affil= kn-affil=岡山大学三朝分院 en-keyword=線維化 (Fibrosis) kn-keyword=線維化 (Fibrosis) en-keyword=コラーゲン (Collagen) kn-keyword=コラーゲン (Collagen) en-keyword=TIMP (tissue inhibitor of metalloproteinase) kn-keyword=TIMP (tissue inhibitor of metalloproteinase) en-keyword=MMP (matrix metalloproteinase) kn-keyword=MMP (matrix metalloproteinase) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=121 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of multiple pancreatic cysts with K-ras point mutation in pure pancreatic juice kn-title=膵液のK-ras遺伝子の突然変異を認めた多発性膵嚢胞の1例 en-subtitle= kn-subtitle= en-abstract=Pancreatic cancer is the one of the leading causes of death among cancer deaths and the early diagnosis is one of the main topics of pancreatic research. Mutation of K-ras oncogene at codon 12 has been reported in pancreatic adenoma, hyperplasia of the pancreatic duct, and also in pancreatic cancer, Recently, detection of K-ras point mutation in pure pancreatic juice is underinvestigation as a potential tool of early diagnosis of pancreatic cancer by setting a certain cut-off value. We recently experienced a case of multiple pancreatic cysts without any malignant cells in pancreatic juice, but with a positve point mutation of K-ras oncogene. Operation was deferred after obtaining informed consent from the family, because the lesions were so multiple and extensive as to require total pancreatectomy. Eighteen months follow-up studies did not reveal any deterioration in imaging tests as well as clinical picture. kn-abstract=膵癌の早期診断を行うために,最近の進歩の著しい遺伝子診断を用いて,膵液中のK-ras遺伝子の点突然変異の検討がなされている｡われわれは膵液の細胞診は陰性であるが,K-ras遺伝子の点突然変異を認め,膵全体に多発する膵嚢胞の1例を経験した｡本例は悪性であるとの確診が得られないことや切除するとなれば膵全摘となることなどのために,経過観察を行っているが,18カ月後の現在,嚢胞の増大など認めていない｡膵癌の遺伝子診断の文献的考察を含め,報告する｡ en-copyright= kn-copyright= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=5 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=9 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=10 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学第2内科 affil-num=2 en-affil= kn-affil=岡山大学中央検査部 affil-num=3 en-affil= kn-affil=岡山大学中央検査部 affil-num=4 en-affil= kn-affil=岡山大学中央検査部 affil-num=5 en-affil= kn-affil=岡山大学中央検査部 affil-num=6 en-affil= kn-affil=岡山大学第2内科 affil-num=7 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=勝山病院 affil-num=10 en-affil= kn-affil=岡山大学三朝分院 affil-num=11 en-affil= kn-affil=岡山大学三朝分院 en-keyword=膵嚢胞 (pancreatic cyst) kn-keyword=膵嚢胞 (pancreatic cyst) en-keyword=膵液 (pancreatic juice) kn-keyword=膵液 (pancreatic juice) en-keyword=K-ras遺伝子 (K-ras oncogene) kn-keyword=K-ras遺伝子 (K-ras oncogene) en-keyword=点突然変異 (point mutation) kn-keyword=点突然変異 (point mutation) en-keyword=細胞診 (cytology) kn-keyword=細胞診 (cytology) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=115 end-page=120 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanisms of pancreatic fibrosis kn-title=膵線維化のメカニズム en-subtitle= kn-subtitle= en-abstract=Pancreatic fibrosis is an outstanding morphological feature in chronic pancreatis although it is seen in pancreatic cancer and convalescent stage of acute pancreatitis. Progressive fibrosis in chronic pancreatitis leads to the destruction and contributes to irreversiblity of chronic pancreatitis. Exact mechanisms of pancreatic fibrosis is not yet unclear, although advances in molecular biology have revealed possible roles of cytokines and growth factors in it. We summarized our understanding of pancreatic fibrosis in the revIew. kn-abstract=膵の線維化は慢性膵炎に特徴的な病理組織所見の一つであるが,その発生機序については不明な点か多い｡慢性膵炎はいったん発症すれば,進行性かつ非可逆性であるとされるが,その非可逆性に膵の線維化が関与するとされる｡膵の線維化の発生機序を明らかにし,線維化に対する根本的な治療法の確立が望まれるところである｡そこで,本稿では今後の膵の線維化の研究課題を明らかにする目的で,現在までの膵臓線維化の発生機序に関する知見を整理した｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=6 ORCID= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=10 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学中央検査部 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学中央検査部 affil-num=5 en-affil= kn-affil=岡山大学中央検査部 affil-num=6 en-affil= kn-affil=岡山大学第2外科 affil-num=7 en-affil= kn-affil=岡山大学第2外科 affil-num=8 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=11 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=12 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=膵臓 (pancreas) kn-keyword=膵臓 (pancreas) en-keyword=線維化 (fibrosis) kn-keyword=線維化 (fibrosis) en-keyword=サイトカイン (cytokine) kn-keyword=サイトカイン (cytokine) en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=75 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Gastro-biliary motility in patients with non-ulcer dyspepsia kn-title=上腹部不定愁訴患者の胃･胆嚢運動に関する研究 en-subtitle= kn-subtitle= en-abstract=Subjective symptoms are quite similar between cystic duct syndrome (CDS) and non-ulcer dyspepsia (NUD) : epigastralgia, hypochondralgia and vague complaints in the upper part of the abdomen. Recently, there has been several reports suggesting that the cause of these disorders is postprandial dysmotility in the gallbladder and stomach. However, there has been no report suggesting incoordination of postprandial gastrobilialy motility as the cause of tha above mentioned complaints in these disorders. The aim of this study was to define the difference of postprandial gastrobiliary motility between patients with NUD and controls. Eight patients with NUD and 10 controls were studied. Gastric emptying time of liquid meal and gallbladder contraction were measured, simultaneously. There was no significant difference between study patients and controls when gastric emptying time and gallbladder contraction rate were compared in isolation. However, when these two parameters were assessed in combination, gastric emptying time was linearly correlated with minimum ballbladder contraction time in controls but not in patients. We conclude that the incoordination between gastric emptying and minimal gallbladder contraction may be one of the major causes of the symptoms in NUD. kn-abstract=現在,上腹部不定愁訴の原因は特定されていない｡その原因を解明するため,上腹部不定愁訴患者8人と健常対照者10人に対して液体食の胃排出能と,食事負荷による胆嚢収縮能を測定した｡胃排出時間,胆嚢収縮能はいずれも両者に有意な差は認められなかった｡健常対照者では胃排出時間と胆嚢収縮時間に有意な相関関係が認められたが,上腹部不定愁訴群では相関関係は認められなかった｡上腹部不定愁訴の原因として胃･胆嚢協調運動障害の存在が示唆 された。 en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=ChowdhuryRiaz en-aut-sei=Chowdhury en-aut-mei=Riaz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=5 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=6 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=10 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=11 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=胃運動 (Gastric motility) kn-keyword=胃運動 (Gastric motility) en-keyword=胆嚢運動 (Biliary motility) kn-keyword=胆嚢運動 (Biliary motility) en-keyword=不定愁訴 (indefinite complaint) kn-keyword=不定愁訴 (indefinite complaint) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=71 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Usefulness of retinol binding protein as a marker for the assessment of nutritional uptake for the preparation of colonosocpy kn-title=大腸前処置法の栄養評価としてのレチノール結合蛋白の有用性の検討 en-subtitle= kn-subtitle= en-abstract=The objective of this study was to evaluate the usefulness of retinol binding protein (RBP), one of rapid turnover proteins, for the assessment of nutritional aspect of the preparation for colonoscopy. Blood samples were drawed before the preparation and after the colonoscopic examination and serum RBP was determined by laser nephrometory. Group A consisted of 10 patients who were administered intestinal lavage solution (Niflec) without no low residual diet. Group B consisted of 27 patients who were adminstered low residual diet for 1 day. Group C consisted of 27 patients who were administered low residual diet for the two consecutive days before colonosocopic examination with intestinal lavage solution and magnesium citrate because sufficient cleanup of intestine were not expected by using the ordinary preparations. The values of serum RBP significantly decreased in group C after the preparation although no significant changes were observed in group A and Group B. We emphasized in estimating the preparation for the colonoscopy assessment of nutrition using serum RBP was needed as well as colonic cleaning. kn-abstract=大腸内視鏡検査の前処置を栄養面から評価する目的で前処置前後にrapid turnover proteinである血中レチノール結合蛋白の変動を検討した｡前日に普通食を用い,当日ニフレックを使用した10例,検査1日前に低残渣食を用いた27例,通常の前処置では良好な腸管洗浄が得られないために検査前2日間低残渣食を用いた27例の3群について,前処置開始前と検査終了後に血中レチノール結合蛋白の変動をみたところ,検査前2日間低残渣食服用群で有意の低下を認めた｡前日普通食群では検査前後で変化を認めず,1日低残渣食服用群では低下傾向を認めたが,有意差は認めなかった｡これまで前処置の成否は腸管洗浄度の面で評価されてきたが,血中レチノール結合蛋白を目標として用いることにより栄養面から評価することができることが考えられた。 en-copyright= kn-copyright= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=1 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ChowdhuryRiaz kn-aut-sei=Chowdhury kn-aut-mei=Riaz aut-affil-num=5 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=6 ORCID= en-aut-name=YamamotoRyoichi en-aut-sei=Yamamoto en-aut-mei=Ryoichi kn-aut-name=山本良一 kn-aut-sei=山本 kn-aut-mei=良一 aut-affil-num=7 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=10 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=11 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=12 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=2 en-affil= kn-affil=勝山病院外科 affil-num=3 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=4 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=7 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部中央検査部 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=12 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=13 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=レチノール結合蛋白 (retinol binding protein) kn-keyword=レチノール結合蛋白 (retinol binding protein) en-keyword=大腸内視鏡 (colonoscopy) kn-keyword=大腸内視鏡 (colonoscopy) en-keyword=前処置 (preparation) kn-keyword=前処置 (preparation) en-keyword=栄養評価 (nutritional assessment) kn-keyword=栄養評価 (nutritional assessment) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=94 end-page=98 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Endoscopic aspiration of pure pancreatic juice is useful in diagnosis and treatment of chronic pancreatitis. kn-title=慢性膵炎診療における内視鏡的純粋膵液採取法の意義 en-subtitle= kn-subtitle= en-abstract=Endoscopical aspiration of pure pancreatic juice is useful in following aspects. Firstly, intraductal secretin test by using this method can be substituted for duodenal secretin test, which is a gold standard examination for estimation of exocrine pancreatic function. In addition, endoscopic aspiration of protein pluge eliminates abdominal pain of some painful patients with chronic pancreatitis. Cytological examination, determination of tumor marker, and detection of oncogene in the obtained pancreatic juice are complementary diagnostic approach to pancreatic cancer, which must be differentially diagnosed from chronic pancreatitis. kn-abstract=内視鏡的純粋膵液採取法の慢性膵炎診療における意義を検討した｡本法を用い,セクレパン100単位静注後10分間膵液を採取するintaraductal secretin test(IDST,膵管内セクレチン試験)はこれまで膵外分泌機能検査のgold standardである十二指腸液を採取するセクレチン試験に代用ができ,しかも10分間の採取時間で終了する利点を有する｡本法を施行することにより,蛋白栓が除去され,痔痛の消失に有用である｡また,慢性膵炎と鑑別を要する膵癌を除外診断するために,本法によって採取した膵液の細胞診,腫瘍マーカー,癌遺伝子の検出は有用である｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=3 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=4 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=9 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学中央検査部 affil-num=2 en-affil= kn-affil=岡山大学中央検査部 affil-num=3 en-affil= kn-affil=岡山大学中央検査部 affil-num=4 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=勝山病院 affil-num=10 en-affil= kn-affil=岡山赤十字病院 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=膵液 (pancreatic juice) kn-keyword=膵液 (pancreatic juice) en-keyword=内視鏡 (endoscopy) kn-keyword=内視鏡 (endoscopy) en-keyword=膵外分泌機能検査 (exocrine pancreatic function test) kn-keyword=膵外分泌機能検査 (exocrine pancreatic function test) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=64 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of eosinophilic gastroenteritis with stenosis in the colon kn-title=大腸の全周性狭窄を呈した好酸球性胃腸炎の1例 en-subtitle= kn-subtitle= en-abstract=We report a case of eosinophilic gastroenteritis with a stenosis in the transverse colon. A patient, 54 year-old-woman, presented to our clinic with abdominal pain and diarrhea. Esophagogastric endoscopy and biopsy were normal. Contrast barium enema examination and colonic endoscopy showed a stenotic segment in the transverce colon. Biopsy specimens obteind from the stenotic segment revealed moderate eosinophilic infiltration in the colonic mucosa. Oral intake of sea shells exacerbated her symptoms. Avoiding sea shells has resulted in the disappearance of symptoms and peripheral blood eosinophilia. The present case was discussed in comparison with the 124 cases heretofore reported in Japan. kn-abstract=大腸に全周性狭窄をきたした好酸球性胃腸炎の1例を報告した｡症例は54才の女性で,腹痛と下痢を主訴に来院した｡上部消化管検査では異常を認めなかったが,下部消化管造影検査と大腸内視鏡検査で横行結腸の全周性狭窄を認め,生検にて大腸粘膜の好酸球浸潤を認めた｡貝料理の摂取にて腹痛発作が出現したが,原因抗原は同定できなかった｡貝類の摂取を避けることにより,症状は消失し,末梢血液中の好酸球増多は消失した｡本邦ではこれまでに124例 の報告があるが,大腸に全周性の狭窄をきたす症例は稀であり,文献的考察を加え報告する｡ en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=KatoTadahiro en-aut-sei=Kato en-aut-mei=Tadahiro kn-aut-name=加藤匡宏 kn-aut-sei=加藤 kn-aut-mei=匡宏 aut-affil-num=4 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=好酸球性胃腸炎 (eosinophilic gastroenteropathy) kn-keyword=好酸球性胃腸炎 (eosinophilic gastroenteropathy) en-keyword=大腸 (colon) kn-keyword=大腸 (colon) en-keyword=狭窄 (stenosis) kn-keyword=狭窄 (stenosis) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=59 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=慢性膵炎患者の全消化管通過に関する研究 kn-title=Studies on whole gut transit in chronic pancreatitis patients en-subtitle= kn-subtitle= en-abstract=慢性膵炎の患者の自覚症状や消化不良には消化管の通過異常が関与している可能性がある｡慢性膵炎患者15例と対象群17例で全消化管通過を測定した｡さらに慢性膵炎患者は自律神経機能について評価した｡全消化管通過は慢性膵炎患者は対象群より早いことが示された｡しかしその機序として推定された自律神経機能異常の有無では全消化管通過に差は認められず,慢性膵炎の消化管機能異常の原因は自律神経異常ではないと推定された｡ kn-abstract=Abnormalities of whole gut transit could contribute to the maldigestion and　digestive symptoms of chronic pancreatitis patients. Whole gut transit was measured by radiopaque markers method. Fifteen chronic pancreatitis patients (2 females, 13 males; age range 40-78 years) and 17 controls (4 females, 13 males, 32-73 years) were studied. Additionally, we also looked for evidence of autonomic neuropathy in the chronic pancreatitis patients by using cardiovascular tests. In chronic pancreatitis, whole gut transit was shorter than controls. These abnormalities were not influenced by the degree of autonomic neuropathy. We conclude that whole gut transit is shorter in chronic pancreatitis patients. en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=全消化管通過 (Whole gut transit) kn-keyword=全消化管通過 (Whole gut transit) END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue= article-no= start-page=82 end-page=87 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=膵癌における癌遺伝子および癌抑制遺伝子 kn-title=Oncogenes and tumor suppressor genes in pancreatic cancer en-subtitle= kn-subtitle= en-abstract=膵癌の予後は惨憺たるものである｡一方で,最近の分子生物学の分野での研究の進歩により,遺伝子レベルでの異常が膵癌では数多く存在することも明らかになってきた｡膵癌の予後を改善するために,発展が期待される膵癌における遺伝子診断や遺伝子治療に向けて現在までの膵癌で明らかになった癌遺伝子(k-ras,erbB-2,Met),癌抑制遺伝子(p53,p16,APC,DDC)について,概説した。 kn-abstract=Recent advances in molecular biology have revealed that a number of oncogenes (K-ras, erbB-2, and Met) and tumor suppressor genes (p53, p16, APC, and DCC) contribute to the development of pancreatic cancer. This paper reviewed the present knowledge of oncogenes and tumor suppressor genes relevant to pancreatic cancer. Further studies on molecular alterations in pancreatic cancer may lead to a better understanding of tumor biology, offering a possibility of development of new diagnostic and therapeutic approaches in the future. en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=6 ORCID= en-aut-name=YokoyamaMotohiro en-aut-sei=Yokoyama en-aut-mei=Motohiro kn-aut-name=横山元浩 kn-aut-sei=横山 kn-aut-mei=元浩 aut-affil-num=7 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=8 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=勝山病院 affil-num=7 en-affil= kn-affil=岡山赤十字病院 affil-num=8 en-affil= kn-affil=岡山赤十字病院 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=Pancreatic cancer kn-keyword=Pancreatic cancer en-keyword=oncogene kn-keyword=oncogene en-keyword=tumor suppressor gene kn-keyword=tumor suppressor gene en-keyword=genetic mutation kn-keyword=genetic mutation END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=84 end-page=87 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interferon and pancreatitis kn-title=膵炎とインターフェロン en-subtitle= kn-subtitle= en-abstract=Pancreatitis is known to be one of the adverse effects of interferon, which has been widely used for treatment of chronic hepatitis and malignant diseases. In this paper, we reviewed pancreatitis as adverse effects of interferon and effect of interferon on the pancreas. kn-abstract=インターフェロンは慢性肝炎や悪性腫瘍の治療など,広く臨床の場に用いられるようになった｡その副作用の一つとして,膵炎があり,その多くは急性膵炎である,慢性膵炎の報告もあり,膵炎はインターフェロンを用いる場合に知っておくべき副作用である｡そこで,膵炎とインターフェロンの関係について現在までに知られている知見について概説する｡ en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=HasuokaHideaki en-aut-sei=Hasuoka en-aut-mei=Hideaki kn-aut-name=蓮岡英明 kn-aut-sei=蓮岡 kn-aut-mei=英明 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=勝山病院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=インターフェロン (interferon) kn-keyword=インターフェロン (interferon) en-keyword=急性膵炎 (acute pancreatitis) kn-keyword=急性膵炎 (acute pancreatitis) en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue= article-no= start-page=79 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=臨床的および実験的側面からみた慢性膵炎とフリーラジカル kn-title=Clinical and experimental aspects of free radicals in chronic pancreatitis en-subtitle= kn-subtitle= en-abstract=慢性肺炎の発症機序は不明な点が多いが､フリーラジカルがそれに関与することが示唆する報告も多い｡しかし,その直接的な証明はなされていない｡慢性膵炎の病態にフリーラジカルがどのように関与するかを理解することは慢性膵炎の発症機序の解明の一助になると考え,臨床的および実験的側面から慢性膵炎とフリーラジカルの関係を概説した｡ kn-abstract=Free radicals have been suspected to play an important role in the pathogenicity of chronic pancreatitis. We reviewed studies on free radicals in chronic pancreatitis in both c1inical and experimental aspects. Many clinical studies have provided circumstantial evidence for the close relation between free radicals and chronic pancreatitis. However, few experimental studies in animals on relation between free radicals and chronic pancreatitis have been reported, because adequate experimental models for elucidating a pathological role of free radicals in chronic pancreatitis have not been established. The research concerning the role of free radicals in chronic pancreatitis is expected to improve our understanding the pathological mechanisms of the disease. en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=MatsumuraNaoki en-aut-sei=Matsumura en-aut-mei=Naoki kn-aut-name=松村直樹 kn-aut-sei=松村 kn-aut-mei=直樹 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=フリーラジカル (free radicals) kn-keyword=フリーラジカル (free radicals) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue= article-no= start-page=76 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=マトリックスメタロプロテアーゼと膵疾患 kn-title=Matrix metalloproteinases (MMPs) and pancreatic diseases en-subtitle= kn-subtitle= en-abstract=マトリックスメタロブロテアーゼ（MMP）は，コラーゲン分解能を有し，種々の疾患との関連性が示唆されている。とりわけ,癌の浸潤，転移には密接な関係があるとされている。また，MMP阻害剤を癌の治療に用いる試みもなされている。本稿ではMMPと膵疾患の関連性，MMP阻害剤の膵癌への応用の可能性について総説する。 kn-abstract=Matrix metalloproteinases (MMPs) is a family of collagenolytic enzymesand are associated with many pathological conditions. Especially, MMPs have a strong relation with tumor progression and invasion. In this review, we focused on association of MMPs and pancreatic diseases, and a potential treatment of MMPs inhibitors for pancreatic cancer. en-copyright= kn-copyright= en-aut-name=YokoyamaMotohiro en-aut-sei=Yokoyama en-aut-mei=Motohiro kn-aut-name=横山元浩 kn-aut-sei=横山 kn-aut-mei=元浩 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=4 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=5 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=2 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=3 en-affil= kn-affil=岡山大学臨床検査医学 affil-num=4 en-affil= kn-affil=岡山大学保険学科 affil-num=5 en-affil= kn-affil=岡山赤十字病院 affil-num=6 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=matrix metalloproteinase(MMP) kn-keyword=matrix metalloproteinase(MMP) en-keyword=tissue inhibitor of metalloproteinase(TIMP) kn-keyword=tissue inhibitor of metalloproteinase(TIMP) en-keyword=pancreatic cancer (膵癌) kn-keyword=pancreatic cancer (膵癌) en-keyword=chronic pancreatitis (慢性膵炎) kn-keyword=chronic pancreatitis (慢性膵炎) END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue= article-no= start-page=60 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IgG4-related disease kn-title=IgG4関連疾患 en-subtitle= kn-subtitle= en-abstract=IgG4-related disease is a new concept which was established in 21st century. Histologically, infiltrations of IgG4-positive plasma cells and lymphocytes occur in the lacrimal gland, salivary gland , retroperitoneum , pancreas , and biliary tract. IgG4-related disease is a systematic disease presenting symptoms such as Mikulicz's disease, retroperitoneal fibrosis, autoimmune pancreatitis, diabetes and sclerotic cholangitis, and oral steroid therapy is effective. In this paper, we propose diagnostic criteria for IgG4-related disease that have not been established yet. If two (or more) of three following features are fulfilled, IgG4-related disease is diagnosed ； elevated levels of serum IgG4, involvement of organs which is characteristic in IgG4-related disease (salivary gland, lacrimal gland, pancreas and retroperitonium) ,histological findings with IgG4-positive plasma cells and lymphocytes. kn-abstract=IgG4関連疾患は21世紀になって提唱された新しい疾患である｡組織学的にはIgG4陽性形質細胞やリンパ球浸潤が涙腺, 唾液腺, 後腹膜, 膵臓, 胆管などで起こり, 臨床的にはMikulicz病, 後腹膜線維症, 自己免疫膵炎, 糖尿病, 原発性硬化性胆管炎類似の胆管病変などを呈する全身性疾患であり, ステロイド治療に対する良好な反応性を認める｡その診断基準は確立されておらず, われわれは, ①血清IgG4の高値, ②本疾患に特徴的な臓器の障害(唾液腺,涙腺, 膵臓, 後腹膜), ③組織学的にIgG4陽性形質細胞とリンパ球の浸潤の確認, の３項目のうち２項目以上認めれば, IgG4関連疾患とするという診断基準を提言する｡ en-copyright= kn-copyright= en-aut-name=HiramatsuKazuhisa en-aut-sei=Hiramatsu en-aut-mei=Kazuhisa kn-aut-name=平松万尚 kn-aut-sei=平松 kn-aut-mei=万尚 aut-affil-num=1 ORCID= en-aut-name=AsanoMotoi en-aut-sei=Asano en-aut-mei=Motoi kn-aut-name=浅野基 kn-aut-sei=浅野 kn-aut-mei=基 aut-affil-num=2 ORCID= en-aut-name=MatsushitaKoki en-aut-sei=Matsushita en-aut-mei=Koki kn-aut-name=松下公紀 kn-aut-sei=松下 kn-aut-mei=公紀 aut-affil-num=3 ORCID= en-aut-name=MiyoshiTomoko en-aut-sei=Miyoshi en-aut-mei=Tomoko kn-aut-name=三好智子 kn-aut-sei=三好 kn-aut-mei=智子 aut-affil-num=4 ORCID= en-aut-name=NakamuraSukio en-aut-sei=Nakamura en-aut-mei=Sukio kn-aut-name=中村好男 kn-aut-sei=中村 kn-aut-mei=好男 aut-affil-num=5 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=6 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name=小出典男 kn-aut-sei=小出 kn-aut-mei=典男 aut-affil-num=7 ORCID= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=2 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=3 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=4 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=5 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=6 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=7 en-affil= kn-affil=岡山大学病院総合診療内科 affil-num=8 en-affil= kn-affil=岡山大学医療教育統合開発センター affil-num=9 en-affil= kn-affil=岡山大学医療教育統合開発センター affil-num=10 en-affil= kn-affil=岡山大学病院三朝医療センター en-keyword=IgG4関連疾患 (IgG4-related disease) kn-keyword=IgG4関連疾患 (IgG4-related disease) en-keyword=自己免疫膵炎 (autoimmune pancreatitis) kn-keyword=自己免疫膵炎 (autoimmune pancreatitis) en-keyword=Mikulicz病 (Mikulicz's disease) kn-keyword=Mikulicz病 (Mikulicz's disease) en-keyword=後腹膜線維症 (retroperitoneal fibrosis) kn-keyword=後腹膜線維症 (retroperitoneal fibrosis) END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue= article-no= start-page=57 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=6種類の血中膵酵素値に及ぼす加齢および性の影響 kn-title=Age and Gender-Related Alterations of Six Serum Pancreatic Enzymes in Healthy Subjects en-subtitle= kn-subtitle= en-abstract=ある種の血中膵酵素値は加齢や性により影響を受けることが知られている。現在膵疾患の診断に利用されている6種類の膵酵素，アミラーゼ，P－アミラーゼ，リパーゼ，トリプシン，フォスフォリパーゼA(2)（PIA(2)），そしてエラスターゼⅠの血中値に及ぼす加齢および性の影響を比較検討した。健常者327名（男性：155名，女性：172名，年齢：20－79歳）を対象として，年齢および性により層別化して検討した。PLA(2)とエラスターゼⅠはRIA，トリプシンはEIA，そして他の酵素は活性を測定した。PLA(2)以外の血中月率酵素値は加齢とともに有意に上昇した。しかし男性では60代以降低下した。性差はアミラーゼとP－アミラーゼとに有意差が認められた。すなわち，アミラーゼは60代以降に，P－アミラーゼは40－49歳群でそれぞれ男性より女性において有意の高値を示した。PLA(2)以外の血中膵酵素値を評価する際には加齢による影響を考慮すべきであり，アミラーゼおよびP－アミラーゼの血中値を評価する際には性を考慮すべきである。 kn-abstract=The serum levels of some pancreatic enzymes have been reported to be affected by age and gender. Currently, serum total amylase, pancreatic isoamylase (P-amylase) , lipase , trypsin (ogen) , pancreatic phospholipase A(2) (PLA(2)) , and elastase I are utilized in diagnosing pancreatic diseases. We here compared age and gender-related alterations of these six pancreatic enzymes in healthy subjects to delineate different properties among the enzymes. Subjects were 155 males and 172 females between ages 20 and 79 years who were apparently healthy, and were stratified by age and sex. PLA(2) and elastase I were assayed by RIA, trypsin (ogen) by EIA and others by activity. The pancreatic enzymes, except PLA(2), were significantly elevated with age, although they declined in males in the 260 age group. There were significant sex differences in total amylase and P-amylase. Total amylase was significantly higher in females than in males in the 260 age group, P-amylase in the 40-49 age group. Age should be considered in the valuation of serum enzymes except PLA(2), sex difference should be considered in the valuation of amylase (total and P-amylase). en-copyright= kn-copyright= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=3 ORCID= en-aut-name=ShinjiToshiyuki en-aut-sei=Shinji en-aut-mei=Toshiyuki kn-aut-name=真治紀之 kn-aut-sei=真治 kn-aut-mei=紀之 aut-affil-num=4 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name=小出典男 kn-aut-sei=小出 kn-aut-mei=典男 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部生休債報医学 affil-num=2 en-affil= kn-affil=岡山大学医学部生休債報医学 affil-num=3 en-affil= kn-affil=岡山大学医学部生休債報医学 affil-num=4 en-affil= kn-affil=岡山大学医学部生休債報医学 affil-num=5 en-affil= kn-affil=岡山大学医学部生休債報医学 en-keyword=pancreatic enzyme kn-keyword=pancreatic enzyme en-keyword=amylase kn-keyword=amylase en-keyword=phospholipase A(2) kn-keyword=phospholipase A(2) en-keyword=aging kn-keyword=aging en-keyword=gender kn-keyword=gender END start-ver=1.4 cd-journal=joma no-vol=2008 cd-vols= no-issue=1 article-no= start-page=117 end-page=120 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of Shape of pen on Usability en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using electromyography (EMG) analysis and psychological rating, the usability of pen was evaluated. The experimental factors wewre the pen diameter (three levels:8mm, 11mm, and 13.8mm). The length of pen tip was fixed to 14mm. Surface EMG was recordes from extensor digitorum and flexxor digitorum superficialis. The EMG before and after a long-hour writing task was measured to evaluate the fatigue of forearm using % MVC (Mean Voluntary Contraction), mean power frequency (MPF) and psychological rating on usability. Concerning % MVC and MPF, the difference before and the experimental task were used for the evaluation. The evaluation value corresponded to subtraction of value after the experimental task from that before the experimental task. As a result of a one-way (pen diameter) ANOVA, no significant main effects of pen diameter were for both EMG evaluation measures. As for the psychological rating on usability, Kruscal-Wallis non-parametric test was carried out. The psychological rating on ease of grip revealed a significant main effect of pen diameter. A pen with a diameter of 11mm was found to have a significant higher rating score. en-copyright= kn-copyright= en-aut-name=MurataAtsuo en-aut-sei=Murata en-aut-mei=Atsuo kn-aut-name=村田厚生 kn-aut-sei=村田 kn-aut-mei=厚生 aut-affil-num=1 ORCID= en-aut-name=MizushimaKensuke en-aut-sei=Mizushima en-aut-mei=Kensuke kn-aut-name=水島健介 kn-aut-sei=水島 kn-aut-mei=健介 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University en-keyword=universal design kn-keyword=universal design en-keyword=usability kn-keyword=usability en-keyword=EMG kn-keyword=EMG en-keyword=pen diameter kn-keyword=pen diameter en-keyword=length of pen tip kn-keyword=length of pen tip en-keyword=psychological rating kn-keyword=psychological rating END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue= article-no= start-page=75 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=食道痛細胞におけるWntのベータカテ二ンTCF経路の活性化の検討 kn-title=Frizzled Activation by Wnt-l Is Required for beta -Catenin -T Cell Factor Dependent Transcription in Esophageal Cancer en-subtitle= kn-subtitle= en-abstract=背景:食道癌細胞にベータカテニンの蓄積があることは報告されているが,大腸癌とことなり,ベータカテニン,Axin,APC変異の報告がなく,そのメカニズムは不明である｡ 方法:8種類の食道癌細胞株において,3種類のWntの刺激によるベータカテニンTCF系の活性化への影響をTCFプロモーターを持つルシュフフェラーゼプラスミドを癌細胞にトランスフェクションして検討した｡ 結果:代表的な食道癌細胞は変異ベータカテニン,変異APC,変異Axinのいずれも,TCFの活性化をおこした｡8種類中7種類の癌細胞はWnt1により量依存性のTCFの活性化が認められたが,Wnt5A,Wnt7Aでは活性化が認められなかった｡ 結語:食道癌の進展にWnt1の関与が示唆された｡ kn-abstract=Although, accumulation of nuclear and cytoplasmic beta-catenin has been observed in ESCCs, mutation of APC and beta-catenin are not found in ESCCs. Therefore, another mechanism for cytoplasmic beta- catenin accumulation might exist in ESCCs. Materials and Methods: Human ESCCs cell lines and the 293 stable transfectants expressing Wnt-1, Wnt-5A, and Wnt-7A were cultured under standard conditions. The TOPFlash or FOPFlash reporter plasmids were transfected. Results: Transfected mutant beta-catenin as well as an axin fragment harbing the GSK3 beta interaction domain, the latter a potent GSK3 beta inhibitor. both robustly activated pTOPFlash in ESCCs cells. When pTOPFlash/pFOPFlash reporters were transfected in ESCCs cell lines followed by cocultivation with 293 cells that stably express Wnt -1, all cell lines except one demonstrated TCF mediated transcriptional. But, cells were co- cultured, Wnt - 7A or Wnt - 5A did not activate TCF mediated transcription in a cell number dependent fashion. Discussion; We report the activation of TCF promoter gene by extemal Wnt stimuli in ESCCs cells. en-copyright= kn-copyright= en-aut-name=MizushimaTakaaki en-aut-sei=Mizushima en-aut-mei=Takaaki kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=EmoriYasuyuki en-aut-sei=Emori en-aut-mei=Yasuyuki kn-aut-name=江盛康之 kn-aut-sei=江盛 kn-aut-mei=康之 aut-affil-num=3 ORCID= en-aut-name=TaniokaHiroaki en-aut-sei=Tanioka en-aut-mei=Hiroaki kn-aut-name=谷岡洋亮 kn-aut-sei=谷岡 kn-aut-mei=洋亮 aut-affil-num=4 ORCID= en-aut-name=SawaKiminari en-aut-sei=Sawa en-aut-mei=Kiminari kn-aut-name=澤公成 kn-aut-sei=澤 kn-aut-mei=公成 aut-affil-num=5 ORCID= en-aut-name=FujiokaShinichi en-aut-sei=Fujioka en-aut-mei=Shinichi kn-aut-name=藤岡真一 kn-aut-sei=藤岡 kn-aut-mei=真一 aut-affil-num=6 ORCID= en-aut-name=ShinjiToshiyuki en-aut-sei=Shinji en-aut-mei=Toshiyuki kn-aut-name=真治紀之 kn-aut-sei=真治 kn-aut-mei=紀之 aut-affil-num=7 ORCID= en-aut-name=KoideNorio en-aut-sei=Koide en-aut-mei=Norio kn-aut-name=小出典男 kn-aut-sei=小出 kn-aut-mei=典男 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯学研究科生体情報医学, 老年医学 en-keyword=esophageal carcinoma kn-keyword=esophageal carcinoma en-keyword=Wnt kn-keyword=Wnt en-keyword=TCF kn-keyword=TCF en-keyword=beta-catenin kn-keyword=beta-catenin END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=411 end-page=418 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Seasonal prevalence of mosquitoes and incidence of Japanese B encephalitis in Kochi City and south-western area of Kochi Prefecture kn-title=高知県の西南地域と高知市におけるコガタアカイエカの季節的消長と日本脳炎患者発生状況 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Adults mosquitoes of Culex tritaeniorhynchus were collected by light traps in a pigsty at Kochi City located in the central Kochi Prefecture and that at Tosashimizu City located in the southern Kochi Prefecture from 1965 to 1972. A marked difference was observed in seasonal fluctuation of mosquito population between the two sites of collection. During the period of observation, the incidence of Japanese encephalitis patients fluctuated in parallel with the average population of mosquitoes collected from June to September. The first incidnece of Japanese encephalitis patients in Kochi Prefecture generally starts from south-western Kochi Prefecture including Tosashimizu City and gradually moves north. This is coincident with the trend observed in the appearance of the first mosquito population in these area. en-copyright= kn-copyright= en-aut-name=MatsuzakiSawako en-aut-sei=Matsuzaki en-aut-mei=Sawako kn-aut-name=松崎沙和子 kn-aut-sei=松崎 kn-aut-mei=沙和子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=高知女子大学家政学部生活生物学教室 en-keyword=mosquito kn-keyword=mosquito en-keyword=Culex tritaeniorhynchus kn-keyword=Culex tritaeniorhynchus en-keyword=light trap kn-keyword=light trap en-keyword=Japanese encephalitis kn-keyword=Japanese encephalitis en-keyword=Kochi Prefecture kn-keyword=Kochi Prefecture END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=373 end-page=386 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical study on idiopathic thrombocytopenic purpura (ITP) Part 2. Analysis of the treatment of ITP and the value of colchicine therapy for the steroid resistant ITP kn-title=特発性血小板減少性紫斑病 (ITP)に関する臨床的研究 第2編 ITP の治療効果の解析とステロイド難反応性ITPに対するコルヒチン療法の意義について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical effects of steroid and colchicine therapy in 49 patients with ITP especially the refractory cases were evaluated in comparison with splenectomy and danazol therapy. There were 27(55%) steroid resistant patients who could not maintain platelet counts of 5×10(4)/μl with prednisolone doses of less than 10mg/day. Among the 16 steroid resistant patients treated with colchicine, there were 3 patients with complete remission and 3 others who had good to excellent response, that is, 6(37.5%) improved overall. This therapy was more effective than splenectomy (33.3%) and danazol (25%). Colchicine was did not effective in patients who did not respond to prednisolone, but was useful when patients showed at least a transient rise of the platelet count with prednisolone. In many cases, a response to colchicine was seen after a month, and in the patients who failed to show a rise in the platelet count after 2 months of colchicine therapy, no benefit was seen even when the therapy was continued. Colchicine is advantageous in the treatment of the steroid resistant ITP over the immunosuppressive agents or high-dose γ-globulin that are expensive and produce only a transient rise in the platelet count. en-copyright= kn-copyright= en-aut-name=TsurumiNaokazu en-aut-sei=Tsurumi en-aut-mei=Naokazu kn-aut-name=鶴見尚和 kn-aut-sei=鶴見 kn-aut-mei=尚和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=steroid resistant ITP kn-keyword=steroid resistant ITP en-keyword=colchicine kn-keyword=colchicine en-keyword=danazol kn-keyword=danazol en-keyword=splenectomy kn-keyword=splenectomy END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=1 article-no= start-page=15 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Geology of Holocene deposits in Mizushima Area, Okayama Prefecture, Japan kn-title=倉敷市水島地域の沖積地盤地質 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The study srea, Mizushima is occupied by polder and reclaimed land. The ground of this area is composed of the Holocene deposits below the surface. The deposits are mostly 10 to 20m in thickness and composed of 2 units, the B Unit and C&D Unit. The B Unit is composed of muddy sand with 2 to 3m in thickness. This unit is thought to be deposited in the mouth of paleoriver. The C&D Unit is composed of marine mud and sand with 10 to 15m in thickness. This unit is especially soft and will expand ground oscillations during an earthquake. en-copyright= kn-copyright= en-aut-name=SuzukiShigeyuki en-aut-sei=Suzuki en-aut-mei=Shigeyuki kn-aut-name=鈴木茂之 kn-aut-sei=鈴木 kn-aut-mei=茂之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Department of Earth Sciences, Okayama University en-keyword=Holocene deposits kn-keyword=Holocene deposits en-keyword=Mizushima Area kn-keyword=Mizushima Area en-keyword=Ground oscillation kn-keyword=Ground oscillation END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=2 article-no= start-page=85 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Public transportation and the disabled person kn-title=身体機能障害者の公共交通機関利用を妨げる要因 en-subtitle= kn-subtitle= en-abstract=A survey was distributed by mail to disabled people who received functional training in 1997. Of 208 questionnaires sent, 125 (60.1%) were returned. Sixty-seven (53.6%) of the respondents had experience traveled outside. People who participate in functional trainning for disability hope to have an attendant to accompany them when traveling. One primary factor that hinders traveling outside and using public transportation is that they cannot ask for help because of shyness. Another factor is the construction of entrances (e.g.,bumps) for vehicles which cannot be traversed easily. Reasons differed among those who had traveled outside and those who had not. It is necessary to prepare an environment (e.g., public transportationto) for ease of use for disabled persons in regional communities. kn-abstract=機能訓練事業として実施している「生活リハビリ教室」の教室生208名を対象に，公共交通機関を利用して外出するために障害になっている要因を明らかにする目的で，郵送法による自記式アンケート調査を行った。回答は125名（60.1％）からあった。外出経験がある者は67名（53.6％）で外出経験がない者が58名であった。外出時に付添いが必要と思っている者は，外出経験のない者に多かった。公共交通機関を利用しての外出を阻害している要因には，乗り物の昇降口に段差があることや早く発車して危険である，また周囲の人に介助を依頼しにくいことなどが挙げられている。身体機能障害者が外出できない理由は個人によって異なってはいるが，地域社会に身体機能障害者を受け入れる環境を整えていく必要がある。 en-copyright= kn-copyright= en-aut-name=HigakiMichiyo en-aut-sei=Higaki en-aut-mei=Michiyo kn-aut-name=檜垣みちよ kn-aut-sei=檜垣 kn-aut-mei=みちよ aut-affil-num=1 ORCID= en-aut-name=AkazawaYoshiko en-aut-sei=Akazawa en-aut-mei=Yoshiko kn-aut-name=赤澤良子 kn-aut-sei=赤澤 kn-aut-mei=良子 aut-affil-num=2 ORCID= en-aut-name=OhtaYasuyo en-aut-sei=Ohta en-aut-mei=Yasuyo kn-aut-name=太田康代 kn-aut-sei=太田 kn-aut-mei=康代 aut-affil-num=3 ORCID= en-aut-name=AkazawaToyoko en-aut-sei=Akazawa en-aut-mei=Toyoko kn-aut-name=赤澤豊子 kn-aut-sei=赤澤 kn-aut-mei=豊子 aut-affil-num=4 ORCID= en-aut-name=OhtaHisae en-aut-sei=Ohta en-aut-mei=Hisae kn-aut-name=太田久恵 kn-aut-sei=太田 kn-aut-mei=久恵 aut-affil-num=5 ORCID= en-aut-name=OhnoNobuko en-aut-sei=Ohno en-aut-mei=Nobuko kn-aut-name=大野伸子 kn-aut-sei=大野 kn-aut-mei=伸子 aut-affil-num=6 ORCID= en-aut-name=MiyakeHiromi en-aut-sei=Miyake en-aut-mei=Hiromi kn-aut-name=三宅浩美 kn-aut-sei=三宅 kn-aut-mei=浩美 aut-affil-num=7 ORCID= en-aut-name=IshiharaHiroe en-aut-sei=Ishihara en-aut-mei=Hiroe kn-aut-name=石原寛恵 kn-aut-sei=石原 kn-aut-mei=寛恵 aut-affil-num=8 ORCID= en-aut-name=MatsuuraNorie en-aut-sei=Matsuura en-aut-mei=Norie kn-aut-name=松浦徳枝 kn-aut-sei=松浦 kn-aut-mei=徳枝 aut-affil-num=9 ORCID= en-aut-name=AbeKeiko en-aut-sei=Abe en-aut-mei=Keiko kn-aut-name=安部啓子 kn-aut-sei=安部 kn-aut-mei=啓子 aut-affil-num=10 ORCID= en-aut-name=AkagiMika en-aut-sei=Akagi en-aut-mei=Mika kn-aut-name=赤木美鹿 kn-aut-sei=赤木 kn-aut-mei=美鹿 aut-affil-num=11 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=12 ORCID= en-aut-name=OkanoHatsue en-aut-sei=Okano en-aut-mei=Hatsue kn-aut-name=岡野初枝 kn-aut-sei=岡野 kn-aut-mei=初枝 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=倉敷市役所水島支所 affil-num=2 en-affil= kn-affil=倉敷市役所水島支所 affil-num=3 en-affil= kn-affil=倉敷市役所水島支所 affil-num=4 en-affil= kn-affil=倉敷市役所水島支所 affil-num=5 en-affil= kn-affil=倉敷市役所水島支所 affil-num=6 en-affil= kn-affil=倉敷市役所水島支所 affil-num=7 en-affil= kn-affil=倉敷市役所水島支所 affil-num=8 en-affil= kn-affil=倉敷市役所水島支所 affil-num=9 en-affil= kn-affil=倉敷市役所水島支所 affil-num=10 en-affil= kn-affil=倉敷市役所水島支所 affil-num=11 en-affil= kn-affil=倉敷市役所水島支所 affil-num=12 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=13 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 en-keyword=身体機能障害者 (disabled person) kn-keyword=身体機能障害者 (disabled person) en-keyword=外出 (traveling) kn-keyword=外出 (traveling) en-keyword=公共交通機関 (public transportation) kn-keyword=公共交通機関 (public transportation) END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=1 article-no= start-page=29 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=1999 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Characteristics of Trace Metal Distribution of Artificial and Natural-Origin Suspended Particulate Matter (SPM) by grain size kn-title=大気浮遊粒子物質（ＳＰＭ）中の天然および人為由来の微量金属の粒径別分布特性 en-subtitle= kn-subtitle= en-abstract=浮遊粒子状物質（0.1～9.0μm）中の酸溶解性金属について、各金属の粒径別濃度分布を検討した。ことに人為起減金属と考えられるPb、Cd、Ni,Crは微小粒子（0～2.0μｍ）部分に存在する事が判明した。これに対し天然起源の金属であるTi、Mn、Mg、Sr等は粗大粒子（2.1～9.0μｍ）に多く存在した。すなわち微小部分に存在する人に由来の金属は酸性雨などによる溶解性が大きいと考えられる。そのために人に由来の金属は動植物のみならず人体への影響も引き起こし易い状況にあることが推察された。また本調査地点の倉敷市は立地的には水島工業地帯の北東に位置していること、西風、南西風が卓越した地点であることから、工業地帯の煙突からの放出物質ならびに自動車排気ガス等の汚染の影響を受けやすいことが判明した。発生源同定、発生源対策等の観点からも、今後において浮遊粒子状物質を含むエアロゾルの粒径別の化学組成の研究、特に微小粒子領域における詳細な研究が望まれる。現在の日本の大気汚染防止法は直径100分の1mm以下の浮遊粒子状物質について基準を設けているが、もっと小さい2.5μｍに焦点を当てた基準等の検討も必要であろう。浮遊粒子状物質には、ほこりやちり等の天然由来のものに含まれるのに対して、2.5μｍ以下は排ガス等の人為的な発生源が中心であり、肺の組織の深部まで到達して沈着しやすく健康への影響も大きいことからも、今後より詳細な研究と汚染防止対策が切望される。 kn-abstract=Air pollution caused by suspended particulate matter (SPM) has increased remarkedly in industrial areas, and this has become an emergency issue in the global environment. Atomospheric SPM influences the local ecosystem including various plants and animals. It is necessary to examine the distribution characteristics of such trace metals in fine particulates (especially those with a diameter (φ) of less than 2.1μm). The Environment Agency of the Japanese goverment will complete analysis of the a concentration of suspended particulate matter less than 2.4μm by the end of 1999, and will be examining the relationship between the concentration of suspended particulate matter (0.1-9.0μm) with consideration given to the particle size throughout two years. It became clear that the metals of artificial origin such as Pb, V, Cd, Ni, Cr, existed in fine particulates (0.1 or more 2.0μm). By contrast, the metals of natural origin, such as Ti, Mn, Mg, Sr, mainly existed in coarse Area in Japan. en-copyright= kn-copyright= en-aut-name=MuramotoShigeki en-aut-sei=Muramoto en-aut-mei=Shigeki kn-aut-name=村本茂樹 kn-aut-sei=村本 kn-aut-mei=茂樹 aut-affil-num=1 ORCID= en-aut-name=MaitaniToshihiko en-aut-sei=Maitani en-aut-mei=Toshihiko kn-aut-name=米谷俊彦 kn-aut-sei=米谷 kn-aut-mei=俊彦 aut-affil-num=2 ORCID= en-aut-name=HiraokaNaoko en-aut-sei=Hiraoka en-aut-mei=Naoko kn-aut-name=平岡直子 kn-aut-sei=平岡 kn-aut-mei=直子 aut-affil-num=3 ORCID= en-aut-name=AoyamaIsao en-aut-sei=Aoyama en-aut-mei=Isao kn-aut-name=青山勲 kn-aut-sei=青山 kn-aut-mei=勲 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=Atomospheric Suspended particulate matter (SPM) kn-keyword=Atomospheric Suspended particulate matter (SPM) en-keyword=Natural-origin metal kn-keyword=Natural-origin metal en-keyword=Artificial-origin metal kn-keyword=Artificial-origin metal en-keyword=Biological effects kn-keyword=Biological effects END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=極低温量子気体における空間的非一様な超流動相の集団及び個別励起 kn-title=Collective and Individual Excitations of Spatially Inhomogeneous Superfluid Phases in Ultracold Quantum Gases en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MizushimaKen en-aut-sei=Mizushima en-aut-mei=Ken kn-aut-name=水島健 kn-aut-sei=水島 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非侵襲的単回検査法による慢性膵炎患者の胃胆嚢運動機能異常の検討 kn-title=Gastrobiliary Motility in Patients with Chronic Pancreatitis as Assessed by a Single Noninvasive Test en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=水島孝明 kn-aut-sei=水島 kn-aut-mei=孝明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=臨海工業地帯開発に伴う水島港海水の衛生学的調査研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=丸屋博 kn-aut-sei=丸屋 kn-aut-mei=博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue=1 article-no= start-page=185 end-page=217 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200411 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=児島湾干拓地七区における農業的土地利用と営農分化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=本研究の課題は、第二次世界大戦後の農業生産が拡大基調にあった時期に造成された国営干拓地を対象とし、干拓地の農業的土地利用の変化と営農分化の要因を明らかにすることを通して、入植者が自然環境・社会環境への適応と対応の仕方を考察するものである。筆者は、この研究課題において、これまで秋田県八郎潟干拓地大潟村、滋賀県琵琶湖の大中の湖干拓地、愛知県の鍋田干拓地を対象に研究調査(1998,1999,2003)をしてきた。これらの中で、八郎潟干拓地大潟村や大中の湖干拓地は、水田稲作・複合経営で比較的農業が維持されている干拓地ととらえ、鍋田干拓地は都市化によって著しく変化がみられる干拓地と位置づけている。 このような中で本論の研究対象地域は、第二次世界大戦後の国営干拓地のうち、入植者たちが営農を開始後、都市化・工業化の影響を強く受けた岡山県の児島湾干拓地七区を取り上げた。干拓地における農業は、干拓地の造成後、新規に開発されるために、伝統的・慣習的制約が少ない。したがって、干拓地の農業的土地利用は、主として入植農家による干拓地の自然環境・社会環境への適応の仕方に規定される。本論では、児島湾干拓地七区の入植者が、水・土壌などの自然的な条件不利地であった干拓地にいかに適応したのか、さらに、個々の入植農家が農政変化や水島や玉野地区の工業化及び岡山市の都市化にいかに対応したのかなど、干拓地をめぐる内的・外的要因から実態分析することによって明らかにしたい。 en-copyright= kn-copyright= en-aut-name=YamanoAkio en-aut-sei=Yamano en-aut-mei=Akio kn-aut-name=山野明男 kn-aut-sei=山野 kn-aut-mei=明男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=児島湾干拓地七区 kn-keyword=児島湾干拓地七区 en-keyword=農業的土地利用 kn-keyword=農業的土地利用 en-keyword=営農分化 kn-keyword=営農分化 END