検索結果 47814 件
| フルテキストURL | tetrahed_lett_59_11_955.pdf |
|---|---|
| 著者 | Takamura, Hiroyoshi| |
| キーワード | Natural product Stereodivergent synthesis Stereodiversification Stereoisomer |
| 発行日 | 2018-02-10 |
| 出版物タイトル | Tetrahedron Letters |
| 巻 | 59巻 |
| 号 | 11号 |
| 出版者 | Pergamon Press |
| 開始ページ | 955 |
| 終了ページ | 966 |
| ISSN | 00404039 |
| NCID | AA00861801 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1016/j.tetlet.2018.02.004 |
| Web of Science KeyUT | 000427217400001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.tetlet.2018.02.004 |
| フルテキストURL | Front_Microbiol_4_144.pdf |
|---|---|
| 著者 | Chowdhury, Goutam| Joshi, Sangeeta| Bhattacharya, Sanjay| Sekar, Uma| Birajdar, Balaji| Bhattacharyya, Arpita| Shinoda, Sumio| Ramamurthy, Thandavarayan| |
| 備考 | This work was supported by the Japan Initiative for Global Research Network for Infectious Diseases, Ministry of Education, Culture, Sports, Science and Technology, Japan.| |
| 発行日 | 2016-02-11 |
| 出版物タイトル | frontiers in Microbiology |
| 巻 | 7巻 |
| 出版者 | Frontiers Research Foundation |
| 開始ページ | 144 |
| ISSN | 1664302X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 26904017 |
| DOI | 10.3389/fmicb.2016.00144 |
| Web of Science KeyUT | 000443434600001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fmicb.2016.00144 |
| フルテキストURL | Plos_Negl_Trop_Dis_5386.pdf |
|---|---|
| 著者 | Imamura, Daisuke| Morita, Masatomo| Sekizuka, Tsuyoshi| Mizuno, Tamaki| Takemura, Taichiro| Yamashiro, Tetsu| Chowdhury, Goutam| Pazhani, Gururaja P.| Mukhopadhyay, Asish K.| Ramamurthy, Thandavarayan| Miyoshi, Shin-ichi| Kuroda, Makoto| Shinoda, Sumio| Ohnishi, Makoto| |
| 備考 | This research is supported by the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) from Ministry of Education, Culture, Sport, Science & Technology in Japan, and Japan Agency for Medical Research and Development (AMED).| |
| 発行日 | 2017-02-13 |
| 出版物タイトル | PLOS Neglected Tropical Diseases |
| 巻 | 11巻 |
| 号 | 2号 |
| 出版者 | PLOS |
| 開始ページ | e0005386 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 28192431 |
| DOI | 10.1371/journal.pntd.0005386 |
| Web of Science KeyUT | 000396406600020 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pntd.0005386 |
| フルテキストURL | Arch_Parasitol_1_2_114.pdf |
|---|---|
| 著者 | Ganguly, Sandipan| Malhotra, Anil| Chowdhuri, Manish| Ghosal, Ajanta| Sanjib Kumar Sardar| Okamoto, Keinosuke| Dutta, Shanta| Bhattacharya, Sujit K| |
| キーワード | Meningoencephalitis Intractable seizure Coma Amoeba Naegleria fowleri |
| 発行日 | 2017-11-30 |
| 出版物タイトル | Archives of Parasitology |
| 巻 | 1巻 |
| 号 | 3号 |
| 出版者 | OMICS International |
| 開始ページ | 1000114 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/AMO/56655 |
|---|---|
| フルテキストURL | 73_2_181.pdf |
| 著者 | Okamura, Tomoka| Washio, Yousuke| Yoshimoto, Junko| Tani, Kazumasa| Tsukahara, Hirokazu| Shimada, Akira| |
| 抄録 | Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF. |
| キーワード | cytarabine Down syndrome exchange transfusion hydrops fetalis transient abnormal myelopoiesis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 181 |
| 終了ページ | 188 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015754 |
| JaLCDOI | 10.18926/AMO/56654 |
|---|---|
| フルテキストURL | 73_2_177.pdf |
| 著者 | Okita, Atsushi| Ohtani, Jun| |
| 抄録 | We report a rare case of fistulation to the jejunum after percutaneous endoscopic gastrostomy (PEG). An 85-year-old man with previous cerebral infarction and swallowing disturbance underwent PEG. Nine months later, he developed a high fever and discharge around the gastrostomy button. He was diagnosed with aspiration pneumonia, and administered antibiotic therapy. Examination showed digestive fluid around the gastrostomy button. Gastrointestinal contrast-enhanced CT revealed a gastrojejunocutaneous fistula. The button was removed, and the fistula closed naturally. PEG was performed again. The patient’s postoperative course was uneventful. Gastrojejunocutaneous fistula should be considered in cases involving increased discharge from a gastrostomy fistula. |
| キーワード | percutaneous endoscopic gastrostomy gastrojejunocutaneous fistula |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 177 |
| 終了ページ | 180 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015753 |
| JaLCDOI | 10.18926/AMO/56653 |
|---|---|
| フルテキストURL | 73_2_173.pdf |
| 著者 | Tamada, Shoko| Masuyama, Hisashi| Hayata, Kei| Eto, Eriko| Mitsui, Takashi| Eguchi, Takeshi| Maki, Jota| Tani, Kazumasa| |
| 抄録 | Radical trachelectomy (RT) is a fertility-sparing surgery for cervical cancer. Postoperative pregnancies have a high risk of abortion and prematurity. To prevent this, a procedure involving transabdominal cerclage (TAC) was devised for shortened cervical canals post-RT. Here we describe the successful management of a pregnancy after abdominal RT (ART). The 34-year-old patient was gravida 1, para 0. When she was 27, she underwent ART for stage Ib1 cervical cancer, and she became pregnant 7 years later. Because her cervical canal was 16.7 mm during early pregnancy, we performed TAC at 12 weeks of pregnancy. Post-surgery, we administered an infusion of ritodrine hydrochloride for tocolysis. A selective caesarean section was performed at 36 weeks, with the delivery of a healthy infant. |
| キーワード | cervical cancer radical trachelectomy pregnancy transabdominal cerclage |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 173 |
| 終了ページ | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015752 |
| JaLCDOI | 10.18926/AMO/56652 |
|---|---|
| フルテキストURL | 73_2_161.pdf |
| 著者 | Okamoto, Sachiyo| Matsuoka, Ken-ichi| Sakamoto, Maiko| Usui, Yoshiaki| Fujiwara, Yuki| Kondo, Takumi| Tani, Katsuma| Saeki, Kyosuke| Meguri, Yusuke| Asada, Noboru| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Maeda, Yoshinobu| |
| 抄録 | Second allogeneic stem cell transplantation (allo-SCT) is a potentially curative therapy for patients who relapse after first allo-SCT. Human leukocyte antigen (HLA)-haploidentical related donors provide the broad opportunity to conduct second SCT at the appropriate time, but the efficacy of second SCT from haploidentical donors after relapse has not been established. We retrospectively analyzed the records of 33 patients who underwent second SCT. Twenty patients underwent haplo-SCT with low-dose antithymocyte globulin (ATG), and the other 13 patients underwent conventional- SCTs, including HLA-matched related peripheral blood, unrelated bone marrow or cord blood. Three years after the second SCT, the overall survival (OS) and progression-free survival (PFS) of all patients were 32.5% and 23.9%. Multivariate analyses indicated that non-complete response at second SCT, less than 1-year interval to relapse after first- SCT, and total score ≥ 3 on the hematopoietic cell transplantation-specific comorbidity index were significantly associated with a lower PFS rate. The haplo- and conventional- SCT groups showed equivalent results regarding OS, PFS, cumulative incidences of relapse, non-relapse mortality and graft-versus-host disease. The neutropenic period after transplantation was significantly shorter in haplo- SCT than conventional- SCT (10.5 days vs. 16 days, p=0.001). Our analysis revealed that haplo-SCT could be an alternative therapeutic option for relapsed patients after first SCT. |
| キーワード | allogeneic stem cell transplantation haploidentical stem cell transplantation relapse anti-T lymphocyte globulin |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 161 |
| 終了ページ | 171 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015751 |
| JaLCDOI | 10.18926/AMO/56651 |
|---|---|
| フルテキストURL | 73_2_155.pdf |
| 著者 | Minami, Daisuke| Kayatani, Hiroe| Sato, Ken| Fujiwara, Keiichi| Shibayama, Takuo| Yonei, Toshiro| Sato, Toshio| |
| 抄録 | We investigated the clinical characteristics of refractory asthma associated with the effectiveness of bronchial thermoplasty (BT). We retrospectively evaluated data from 10 patients who underwent BT between June 2016 and December 2017 at Okayama Medical Center. The following were measured before and 6 months post-BT: forced expiratory volume in 1.0 s (FEV1), fractional exhaled nitric oxide (FeNO), immunoglobulin E (IgE) level, blood eosinophil counts (Eosi), Asthma Quality of Life Questionnaire (AQLQ) score, and preventive medication use. At baseline, the mean post-bronchodilator FEV1 was 80.9% of the predicted value (range 45.6-115.7%). All patients were being treated with moderate- or high-dose inhaled corticosteroids and long-acting β2 agonists. The AQLQ improved from 4.26±1.67 at baseline to 5.59±0.94 at 6 months post-BT (p<0.05). The %FEV1, FeNO, IgE, and Eosi did not change significantly between baseline and 6 months post-BT. No severe complications were reported. BT was effective for non-allergic and non-eosinophilic in 3 patients, and allergic or eosinophilic in 4 patients. Their AQLQ improved by > 0.5 points post-BT. For both allergic and eosinophilic asthmatics following mepolizumab, BT was not useful. BT was effective for non-allergic and non-eosinophilic or allergic asthmatics, but insufficient for both allergic and eosinophilic following mepolizumab. |
| キーワード | bronchial thermoplasty non-allergic asthma non-eosinophilic asthma airway hyper-responsiveness patient selection |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 155 |
| 終了ページ | 160 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015750 |
| JaLCDOI | 10.18926/AMO/56650 |
|---|---|
| フルテキストURL | 73_2_147.pdf |
| 著者 | Hayashi, Masao| Taniguchi, Arata| Kaku, Ryuji| Fujimoto, Shusaku| Isoyama, Satoshi| Manabe, Sei| Yoshida, Tsubasa| Suzuki, Satoshi| Shimizu, Kazuyoshi| Morimatsu, Hiroshi| Momota, Ryusuke| |
| 抄録 | Tachycardia is common in intensive care units (ICUs). It is unknown whether tachycardia or prolonged tachycardia affects patient outcomes. We investigated the association between tachycardia and mortality in critically ill patients. This retrospective cohort study’s primary outcome was patient mortality in the ICU and the hospital. We stratified the patients (n=476) by heart rate (HR) as LowHR, MediumHR, and HighHR groups. We also stratified them by their durations of HR >100 (prolonged HR; tachycardia): MildT, ModerateT, and SevereT groups. We determined the six groups’ mortality. The ICU mortality rates of the LowHR, MediumHR, and HighHR groups were 1.0%, 1.5%, and 7.9%, respectively; significantly higher in the HighHR vs. LowHR group. The in-hospital mortality rates of these groups were 1%, 4.5%, and 14.6%, respectively; significantly higher in the HighHR vs. LowHR group. The ICU mortality rates of the MildT, ModerateT, and SevereT groups were 0.9%, 5.6%, and 57.1%, respectively. The mortality of the HRT=0 (i.e., all HR ≤ 100) patients was 0%. The in-hospital mortality rates of the MildT, ModerateT, and SevereT groups were 1.8%, 16.7%, and 85.7%, respectively; that of the HRT=0 patients was 0.5%. Both higher HR and prolonged tachycardia were associated with poor outcomes. |
| キーワード | tachycardia mortality ICU in-hospital |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 147 |
| 終了ページ | 153 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015749 |
| JaLCDOI | 10.18926/AMO/56649 |
|---|---|
| フルテキストURL | 73_2_135.pdf |
| 著者 | Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka| |
| 抄録 | The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization. |
| キーワード | collagen XVIII basement membrane wound healing re-epithelialization skin |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 135 |
| 終了ページ | 146 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015748 |
| JaLCDOI | 10.18926/AMO/56648 |
|---|---|
| フルテキストURL | 73_2_127.pdf |
| 著者 | Iwasaki, Yukari| Miyahara, Kimiko| Miyatake, Nobuyuki| Nakatsuka, Mikiya| |
| 抄録 | We aimed to clarify the state of thyroid function in female high school long-distance runners. We evaluated the associations between thyroid function and menstrual condition, bone mineral density (BMD), nutritious status, and body composition. The subjects’ height and weight were measured, along with fat percentage, fat mass, muscle mass, and BMD with dual-energy X-ray absorptiometry. A nutrition and dietary survey measured the subjects’ intake of energy and nutrients based on meals provided at the subjects’ dorm for 3 days in July of 2016 and 2017. Blood parameters including thyroid hormone and estradiol were measured. Most of the subjects (81.3%) were underweight (body mass index <18.5). The thyroid hormone free T3 value was decreased, but TSH was not increased and was similar to that observed in individuals with anorexia nervosa. In our subjects, thyroid hormone was associated with BMD and nutritional intake. To improve the menstruation abnormality of female athletes and to increase their bone density, the athletes’ weight should be managed by proper nutrient intake and the maintenance of their thyroid function. |
| キーワード | thyroid function nutritious status female high school long-distance runners bone mineral density menstrual condition |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 127 |
| 終了ページ | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015747 |
| JaLCDOI | 10.18926/AMO/56647 |
|---|---|
| フルテキストURL | 73_2_117.pdf |
| 著者 | Yamasaki, Yukie| Tamiya, Nanako| Yamamoto, Hideki| Miyaishi, Satoru| |
| 抄録 | According to the World Health Organization’s World Report, approx. 950,000 children and young people < 18 years old die from an injury each year, and unintentional injury deaths account for a large portion of these cases. Here we used medico-legal documents to epidemiologically analyze the cases of unintentional injury deaths among children < 5 years old in Okayama Prefecture, Japan from 2001 to 2015. Age, sex, manner/cause of death, and various circumstances of the incident were investigated. There were 73 unintentional injury deaths during the study period. Drowning (n=29), suffocation (n=24), and transport accidents (n=13) were the major categories of unintentional injury deaths. Twenty-two cases (30.1%) were autopsied. Differences in the characteristics of the unintentional injury deaths by age were observed. Information which cannot be obtained from Vital Statistics was available from medico-legal documents, and detailed characteristics of unintentional injury deaths among children < 5 years old were elucidated. Investigating medico-legal information is one of the meaningful measures for the prevention of unintentional injury deaths among children in Japan. |
| キーワード | child death unintentional injury prevention medico-legal document |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 117 |
| 終了ページ | 125 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015746 |
| JaLCDOI | 10.18926/AMO/56646 |
|---|---|
| フルテキストURL | 73_2_109.pdf |
| 著者 | Abe, Makoto| Iwamuro, Masaya| Kawahara, Yoshiro| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Tsumura, Munechika| Makino, Takuma| Noda, Yohei| Marunaka, Hidenori| Nishizaki, Kazunori| Okada, Hiroyuki| |
| 抄録 | The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. “Resect and watch” is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer. |
| キーワード | endoscopic submucosal dissection superficial cancer pharynx endoscopic resection |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 109 |
| 終了ページ | 115 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015745 |
| JaLCDOI | 10.18926/AMO/56645 |
|---|---|
| フルテキストURL | 73_2_101.pdf |
| 著者 | Iida, Atsuyoshi| Naito, Hiromichi| Yorifuji, Takashi| Zamami, Yoshito| Yamada, Akane| Koga, Tadashi| Imai, Toru| Sendo, Toshiaki| Nakao, Atsunori| Ichiba, Shingo| |
| 抄録 | Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits. |
| キーワード | sedatives ECMO polyvinyl chloride pharmacokinetics pharmacodynamics |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 101 |
| 終了ページ | 107 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015744 |
| JaLCDOI | 10.18926/AMO/56644 |
|---|---|
| フルテキストURL | 73_2_95.pdf |
| 著者 | Ercan, Sabriye| Başkurt, Ferdi| Başkurt, Zeliha| Çetin, Cem| |
| 抄録 | The aim of this study was to examine effect of fatigue levels on functional mobility and balance in middle-aged obese females. The study included 98 healthy females aged 40-60 years with BMI ≥ 30 kg/m2. Self-perceived fatigue was evaluated with a self-administered questionnaire, the Checklist of Individual Strength in Turkish (CIS-T), on which 62.3% of the study subjects identified themselves as fatigued. The body weight and BMI values of fatigued subjects were found to be higher than those of the non-fatigue group (p<0.05). The reported exercise habits of the fatigue group were found to be significantly lower than their non-fatigued peers (p<0.05). The level of functional mobility (Timed Up and Go Test), static balance (One-Legged Stance Test with Eyes Open) and dynamic balance (Functional Reach Test and the 3-meter Timed Tandem Walk Test) were measured, and statistically significant differences were found between fatigue and non-fatigue groups on all of them (p<0.05). In addition, correlations were found between the sub-parameters of the CIS-T scale and the functional tests at |
| キーワード | fatigue obesity mobility balance woman |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 95 |
| 終了ページ | 100 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015743 |
| タイトル（別表記） | The 92th Okayama Chest Disease Conference |
|---|---|
| フルテキストURL | 130_185.pdf |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-12-03 |
| 巻 | 130巻 |
| 号 | 3号 |
| 開始ページ | 185 |
| 終了ページ | 185 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| タイトル（別表記） | The 22nd Annual Meeting of Japanese Association of Cancer Immunology : From the Banquet to the Beginning |
|---|---|
| フルテキストURL | 130_183.pdf |
| 著者 | 鵜殿 平一郎| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-12-03 |
| 巻 | 130巻 |
| 号 | 3号 |
| 開始ページ | 183 |
| 終了ページ | 184 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| フルテキストURL | 130_181_182.pdf |
|---|---|
| 著者 | 布施 春樹| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-12-03 |
| 巻 | 130巻 |
| 号 | 3号 |
| 開始ページ | 181 |
| 終了ページ | 182 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Why simulation education：The ultimate method of active learning |
|---|---|
| フルテキストURL | 130_179.pdf |
| 著者 | 万代 康弘| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-12-03 |
| 巻 | 130巻 |
| 号 | 3号 |
| 開始ページ | 179 |
| 終了ページ | 180 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.179 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.179 |
| NAID | 130007542829 |