検索結果 - 岡山大学学術成果リポジトリ

Multicentred surgical site infection surveillance using partitioning analysis

著者	Fujiwara, Y.\| Yamada, T.\| Naomoto, Y.\| Yamatsuji, T.\| Shirakawa, Y.\| Tanabe, S.\| Noma, K.\| Kimura, T.\| Aoki, H.\| Matsukawa, H.\| Kimura, M.\| Nonaka, Y.\| Sasaki, H.\| Onoda, T.\| Otawa, Y.\| Takaoka, M.\| Fukazawa, T.\| Ohno, Y.\| Fujiwara, T.\|
発行日	2013-12
出版物タイトル	Journal of Hospital Infection
巻	85巻
号	4号
資料タイプ	学術雑誌論文

Regional Variation in Survival Following Pediatric Out-of-Hospital Cardiac Arrest

著者	Okamoto, Yoshio\| Iwami, Taku\| Kitamura, Tetsuhisa\| Nitta, Masahiko\| Hiraide, Atsushi\| Morishima, Tsuneo\| Kawamura, Takashi\|
発行日	2013-10
出版物タイトル	Circulation Journal
巻	77巻
号	10号
資料タイプ	学術雑誌論文

Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients

著者	Tatsukawa, Masashi\| Takaki, Akinobu\| Shiraha, Hidenori\| Koike, Kazuko\| Iwasaki, Yoshiaki\| Kobashi, Haruhiko\| Fujioka, Shin-Ichi\| Sakaguchi, Kohsaku\| Yamamoto, Kazuhide\|
発行日	2011-10-21
出版物タイトル	BMC Cancer
巻	11巻
資料タイプ	学術雑誌論文

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease

著者	Kitagawa, Masashi\| Sugiyama, Hitoshi\| Morinaga, Hiroshi\| Inoue, Tatsuyuki\| Takiue, Keiichi\| Ogawa, Ayu\| Yamanari, Toshio\| Kikumoto, Yoko\| Uchida, Haruhito Adam\| Kitamura, Shinji\| Maeshima, Yohei\| Nakamura, Kazufumi\| Ito, Hiroshi\| Makino, Hirofumi\|
発行日	2013-02-19
出版物タイトル	PLoS ONE
巻	8巻
号	2号
資料タイプ	学術雑誌論文

てんかん治療ガイドラインについて

著者	森本展年\| 阿部康二\|
発行日	2014-04-01
出版物タイトル	岡山医学会雑誌
巻	126巻
号	1号
資料タイプ	学術雑誌論文

食道原発悪性黒色腫の１切除例

タイトル（別表記）	A patient with primary malignant melanoma of the esophagus who underwent esophagectomy
フルテキストURL	126_45.pdf
著者	前田直見\| 白川靖博\| 國府島健\| 大原利章\| 田邊俊輔\| 野間和広\| 櫻間教文\| 藤原俊義\|
抄録	We report the case of a 61-old-man with a primary malignant melanoma of the esophagus, an extremely rare and highly aggressive malignancy. He presented with dysphagia, and we performed an upper gastrointestinal endoscopy that detected a tumor in the thoracic part of the esophagus. The biopsy showed malignant melanoma. PET/CT, endoscopy and an esophagogram showed that a 70-mm scaled type 2+1 tumor in the thoracic esophagus and no metastases. We diagnosed a cT3cN0cM0 cStage II tumor. We then performed a subtotal esophagectomy with two-field lymph node dissection and esophagogastrostomy via a retrosternal route. The pathological examination of the resected specimens confirmed that the type 2+1 tumor was PMME (pT2N0M0 pStage II). We administered six courses of postoperative adjuvant chemotherapy with dacarbazine, and the patient has had no recurrence for 17 months after the surgery.
キーワード	食道（esophagus）悪性黒色腫（malignant melanoma）
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	45
終了ページ	48
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.45
NAID	130004505808

術前DCF療法が著効した食道原発内分泌細胞癌の１切除例

タイトル（別表記）	Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil
フルテキストURL	126_39.pdf
著者	前田直見\| 白川靖博\| 國府島健\| 大原利章\| 田邊俊輔\| 野間和広\| 櫻間教文\| 藤原俊義\|
抄録	Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3.
キーワード	食道癌（esophageal cancer）内分泌細胞癌（endocrine cell carcinoma） DCF療法（DCF treatment）
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	39
終了ページ	43
ISSN	0030-1558
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.39
NAID	130004505807

早期乳癌におけるOne-step Nucleic Acid Amplification(OSNA)法によるセンチネルリンパ節転移診断の検討

タイトル（別表記）	Evaluation of a one-step nucleic acid amplification (OSNA) assay for sentinel lymph node metastases in early breast cancer
フルテキストURL	126_25.pdf
著者	溝尾妙子\| 枝園忠彦\| 伊藤麻衣子\| 野上智弘\| 岩本高行\| 元木崇之\| 平成人\| 松岡順治\| 土井原博義\|
抄録	Introduction: The one-step nucleic acid amplification (OSNA) assay is a new method to detect sentinel lymph node (SLN) metastases using cytokeratin 19 (CK19) mRNA in early breast cancer. Here we retrospectively analyzed the advantages and disadvantages of the OSNA assay. 　Methods: In a trial period, SLNs were divided into two sections, and we examined one side using the OSNA assay. The other side was examined by pathologists. After this period, we examined whole SLNs using only the OSNA assay. The patients with positive nodes by OSNA assay and/or pathology required axillary dissection. 　Results: We examined 27 primary breast cancer patients (36 SLNs) during the trial period. The overall concordance rate between the OSNA assay and pathology results was 91%. In the later period, 157 patients (217 SLNs) were examined. The CK19-positive rate obtained by the OSNA assay was 16.5% (macrometastases OSNA (++) : 7.2%, micrometastases OSNA (+) : 9.2%). The non-SLN positive rate among the CK19-positivecases was 23%. The OSNA assay's false negative was one case in which the expression of CK-19 on the primary tumor and lymph node was not detected. 　Conclusions: Our OSNA assay results were comparable to those obtained using a conventional pathological technique. Pathologists and laboratory technicians could save time and effort by using the OSNA assay when seeking the precise diagnosis during surgery.
キーワード	OSNA法（OSNA method）センチネルリンパ節（sentinel lymph node） micrometastases CK-19
出版物タイトル	岡山医学会雑誌
発行日	2014-04-01
巻	126巻
号	1号
開始ページ	25
終了ページ	30
ISSN	0030-1558
関連URL	http://www.okayama-u.ac.jp/user/oma/
言語	日本語
著作権者	Copyright (c) 2014 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.126.25

Robot-Assisted Radical Prostatectomy:Modified Ultradissection Reduces pT2 Positive Surgical Margins on the Bladder Neck

JaLCDOI	10.18926/AMO/52142
フルテキストURL	68_1_35.pdf
著者	Araki, Motoo\| Jeong, Wooju\| Park, Sung Yul\| Lee, Young Hoon\| Nasu, Yasutomo\| Kumon, Hiromi\| Hong, Sung Joon\| Rha, Koon Ho\|
抄録	The purpose of this study was to compare the positive surgical margin (PSM) rates of 2 techniques of robot-assisted radical prostatectomy (RARP) for pT2 (localized) prostate cancer. A retrospective analysis was conducted of 361 RARP cases, performed from May 2005 to September 2008 by a single surgeon (KHR) at our institution (Yonsei University College of Medicine). In the conventional technique, the bladder neck was transected first. In the modified ultradissection, the lateral border of the bladder neck was dissected and then the bladder neck was transected while the detrusor muscle of the bladder was well visualized. Perioperative characteristics and outcomes and PSM rates were analyzed retrospectively for pT2 patients (n＝217), focusing on a comparison of those undergoing conventional (n＝113) and modified ultradissection (n＝104) techniques. There was no difference between the conventional and modified ultradissection group in mean age, BMI, PSA, prostate volume, biopsy Gleason score, and DʼAmico prognostic criteria distributions. The mean operative time was shorter (p＜0.001) and the estimated blood loss was less (p＜0.01) in the modified ultradissection group. The PSM rate for the bladder neck was significantly reduced by modified ultradissection, from 6.2% to 0% (p＜0.05). In conclusion, modified ultradissection reduces the PSM rate for the bladder neck.
キーワード	robot-assisted radical prostatectomy prostate cancer surgery surgical margin technique
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-02
巻	68巻
号	1号
出版者	Okayama University Medical School
開始ページ	35
終了ページ	41
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24553487
Web of Science KeyUT	000331592800006

Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor

JaLCDOI	10.18926/AMO/52139
フルテキストURL	68_1_17.pdf
著者	Moritou, Yuki\| Ikeda, Fusao\| Iwasaki, Yoshiaki\| Baba, Nobuyuki\| Takaguchi, Kouichi\| Senoh, Tomonori\| Nagano, Takuya\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Ohnishi, Hideki\| Miyake, Yasuhiro\| Takaki, Akinobu\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
抄録	The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy.
キーワード	hepatic steatosis genetic polymorphism interferon HCV
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-02
巻	68巻
号	1号
出版者	Okayama University Medical School
開始ページ	17
終了ページ	22
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24553484
Web of Science KeyUT	000331592800003

The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma

著者	Muraoka, Takayuki\| Soh, Junichi\| Toyooka, Shinichi\| Aoe, Keisuke\| Fujimoto, Nobukazu\| Hashida, Shinsuke\| Maki, Yuho\| Tanaka, Norimitsu\| Shien, Kazuhiko\| Furukawa, Masashi\| Yamamoto, Hiromasa\| Asano, Hiroaki\| Tsukuda, Kazunori\| Kishimoto, Takumi\| Otsuki, Takemi\| Miyoshi, Shinichiro\|
発行日	2013-12
出版物タイトル	Lung Cancer
巻	82巻
号	3号
資料タイプ	学術雑誌論文

A20 (TNFAIP3) Deletion in Epstein-Barr Virus-Associated Lymphoproliferative Disorders/Lymphomas

著者	Ando, Midori\| Sato, Yasuharu\| Takata, Katsuyoshi\| Nomoto, Junko\| Nakamura, Shigeo\| Ohshima, Koichi\| Takeuchi, Tamotsu\| Orita, Yorihisa\| Kobayashi, Yukio\| Yoshino, Tadashi\|
発行日	2013-02-13
出版物タイトル	PLoS ONE
巻	8巻
号	2号
資料タイプ	学術雑誌論文

Architecture of the Subendothelial Elastic Fibers of Small Blood Vessels and Variations in Vascular Type and Size

著者	Shinaoka, Akira\| Momota, Ryusuke\| Shiratsuchi, Eri\| Kosaka, Mitsuko\| Kumagishi, Kanae\| Nakahara, Ryuichi\| Naito, Ichiro\| Ohtsuka, Aiji\|
発行日	2013-04
出版物タイトル	Microscopy and Microanalysis
巻	19巻
号	2号
資料タイプ	学術雑誌論文

Impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification

著者	Maki, Yuho\| Soh, Junichi\| Ichimura, Kouichi\| Shien, Kazuhiko\| Furukawa, Masashi\| Muraoka, Takayuki\| Tanaka, Norimitsu\| Ueno, Tsuyoshi\| Yamamoto, Hiromasa\| Asano, Hiroaki\| Tsukuda, Kazunori\| Toyooka, Shinichi\| Miyoshi, Shinichiro\|
発行日	2013-01
出版物タイトル	Oncology Reports
巻	29巻
号	1号
資料タイプ	学術雑誌論文

Effects of Biliverdin Administration on Acute Lung Injury Induced by Hemorrhagic Shock and Resuscitation in Rats

著者	Kosaka, Junko\| Morimatsu, Hiroshi\| Takahashi, Toru\| Shimizu, Hiroko\| Kawanishi, Susumu\| Omori, Emiko\| Endo, Yasumasa\| Tamaki, Naofumi\| Morita, Manabu\| Morita, Kiyoshi\|
発行日	2013-05-07
出版物タイトル	PLoS ONE
巻	8巻
号	5号
資料タイプ	学術雑誌論文

Serum cystatin C as a biomarker of cardiac diastolic dysfunction in patients with cardiac disease and preserved ejection fraction

著者	Nosaka, Kazumasa\| Nakamura, Kazufumi\| Kusano, Kengo\| Toh, Norihisa\| Tada, Takeshi\| Miyoshi, Toru\| Doi, Masayuki\| Kohno, Kunihisa\| Morita, Hiroshi\| Ito, Hiroshi\|
発行日	2013-08
出版物タイトル	Congestive Heart Failure
巻	19巻
号	4号
資料タイプ	学術雑誌論文

Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population

著者	Kubota, Junichi\| Ikeda, Fusao\| Terada, Ryo\| Kobashi, Haruhiko\| Fujioka, Shin-ichi\| Okamoto, Ryoichi\| Baba, Shinsuke\| Morimoto, Youichi\| Ando, Masaharu\| Makino, Yasuhiro\| Taniguchi, Hideaki\| Yasunaka, Tetsuya\| Miyake, Yasuhiro\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
発行日	2009-09
出版物タイトル	Journal of Gastroenterology
巻	44巻
号	9号
資料タイプ	学術雑誌論文

DNA Methylation of Colon Mucosa in Ulcerative Colitis Patients: Correlation with Inflammatory Status

著者	Saito, Shunsuke\| Kato, Jun\| Hiraoka, Sakiko\| Horii, Joichiro\| Suzuki, Hideyuki\| Higashi, Reiji\| Kaji, Eisuke\| Kondo, Yoshitaka\| Yamamoto, Kazuhide\|
発行日	2011-09
出版物タイトル	Inflammatory Bowel Diseases
巻	17巻
号	9号
資料タイプ	学術雑誌論文

In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Jurkat Cells Using Bio-phantoms

JaLCDOI	10.18926/AMO/52009
フルテキストURL	67_6_359.pdf
著者	Katashima, Kazunori\| Kuroda, Masahiro\| Ashida, Masakazu\| Sasaki, Takanori\| Taguchi, Takehito\| Matsuzaki, Hidenobu\| Murakami, Jun\| Yanagi, Yoshinobu\| Hisatomi, Miki\| Hara, Marina\| Kato, Hirokazu\| Ohmura, Yuichi\| Kobayashi, Tomoki\| Kanazawa, Susumu\| Harada, Sosuke\| Takemoto, Mitsuhiro\| Ohno, Seiichiro\| Mimura, Seiichi\| Asaumi, Junichi\|
抄録	It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30sec. Heating at 42℃ was used to induce apoptosis while heating at 48℃ was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3μm. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30msec might be optimal to distinguish between apoptosis and necrosis.
キーワード	ADC apoptosis necrosis hyperthermia cell density
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-12
巻	67巻
号	6号
出版者	Okayama University Medical School
開始ページ	359
終了ページ	367
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	24356720
Web of Science KeyUT	000328915700004

Cartilage-Specific Over-Expression of CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Stimulates Insulin-Like Growth Factor Expression and Bone Growth

著者	Tomita, Nao\| Hattori, Takako\| Itoh, Shinsuke\| Aoyama, Eriko\| Yao, Mayumi\| Yamashiro, Takashi\| Takigawa, Masaharu\|
発行日	2013-03-28
出版物タイトル	PLoS ONE
巻	8巻
号	3号
資料タイプ	学術雑誌論文