このエントリーをはてなブックマークに追加


ID 40691
フルテキストURL
タイトル(別表記)
Usefulness of avirulent strains in investigation of latent infection of herpes simplex virus type 1
著者
荒尾 雄二郎 岡山大学医学部ウイルス学教室
抄録
The usefulness of avirulent strains of herpes simplex virus type 1 (HSV-1) in investigations of latency was examined. Trigeminal ganglia (TG) latently infected with HSV-1 were obtained more efficiently from mice inoculated with an avirulent strain, SKO-1B, than from those inoculated with a virulent strain, F. Moreover, utilization of two avirulent strains, SKO-1B and -GCr Miyama, allowed us to compare the rate of reactivatable latency (RL) in these strains. Cultivation of explants of TG recovered from mice inoculated with the same dose of either infectious virus revealed a significant difference in the rate of RL between the two strains. Both strains were revealed to be neither hypersensitive nor resistant to acyclovir, indicating that the difference in the rate of RL between the two strains was not due to any deficient activity of viral ribonucleotide reductase and/or thymidine kinase. The recovery rate of the -GCr virus from explants of TG latently infected with this virus was greatly enhanced by treatment of the explants with sodium n-butyrate during in vitro cultivation. As such, at least one of the mechanisms responsible for causing a very low rate of RL in TG infected with -GCr Miyama may be reduced expression of immediate-early genes of this virus in latently infected cells in vitro.
キーワード
herpes simplex virus type 1
latent infection
reactivation
neurovirulence
発行日
1990-12
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
102巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1253
終了ページ
1259
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/102/11-12/102_11-12_1253/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
日本語
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma