検索結果 1281 件
| 著者 | 四方 賢一| |
|---|---|
| 発行日 | 2011-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 三好 健太郎| 大藤 剛宏| 大谷 真二| 田中 真| 原田 昌明| 柿下 大一| 堀 志郎| 脇 直久| 山根 正修| 三好 新一郎| |
|---|---|
| 発行日 | 2011-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 張 継勇| |
|---|---|
| 発行日 | 2011-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 佐藤 千景| |
|---|---|
| 発行日 | 2011-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 123巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Nagataki, Hiroyuki| Noguchi, Koji| Katsuma, Ryo| Yamauchi, Yukiko| Shibata, Naoki| Yasumoto, Keiichi| Ito, Minoru| |
|---|---|
| 発行日 | 2011-05 |
| 出版物タイトル | Proceedings of CSEDU 2011 - 3rd International Conference on Computer Supported Education |
| 巻 | 1巻 |
| 資料タイプ | 会議発表論文 |
| JaLCDOI | 10.18926/OER/47078 |
|---|---|
| タイトル（別表記） | Takashi Onishi, Tokumi Odagiri, Ryohei Nakamura, Hiroyuki Yasujima, Kou Fujiyama A Marginal Hamlet |
| フルテキストURL | oer_043_2_065_073.pdf |
| 著者 | 神立 春樹| |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2011-09-26 |
| 巻 | 43巻 |
| 号 | 2号 |
| 開始ページ | 65 |
| 終了ページ | 73 |
| ISSN | 0386-3069 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2011 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 40018962708 |
| JaLCDOI | 10.18926/OER/47077 |
|---|---|
| タイトル（別表記） | J. H. Clapham, An Economic History of Modern Britain, vol.1, Britain on the Eve of the Railway Age, 1820−1850（1926）, Outline |
| フルテキストURL | oer_043_2_045_063.pdf |
| 著者 | 一ノ瀬 篤| |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2011-09-26 |
| 巻 | 43巻 |
| 号 | 2号 |
| 開始ページ | 45 |
| 終了ページ | 63 |
| ISSN | 0386-3069 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2011 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 40018962707 |
| JaLCDOI | 10.18926/OER/47076 |
|---|---|
| フルテキストURL | oer_043_2_029_044.pdf |
| 著者 | Xuan, Chao| Nakamura, Ryohei| |
| 抄録 | This paper treats the empirical issue related to the urban productive efficiency. First, we construct a model incorporating urban inefficiency term and estimate a stochastic frontier production function at urban level. Next, we compare technical efficiency across Chinese cities during 1997-2007 by using estimated results. The urban technical inefficiency effect is found to be significant in many cities. Then, in the way of constructing the specification of the technical inefficiency in terms of various capital explanatory variables, we analyze the determinants of technical inefficiency of individual cities, and explore how the urban technical inefficiency is influenced by capital density, FDI, the domestic investment, while the impact of technical inefficiency on capital variables is investigated. From the empirical results, FDI is able to reduce effectively the technical inefficiency. Capital intensive industry would be the engine of economic growth in the future. |
| キーワード | technical inefficiency urban productivity stochastic frontier approach chinese cities |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2011-09-26 |
| 巻 | 43巻 |
| 号 | 2号 |
| 開始ページ | 29 |
| 終了ページ | 44 |
| ISSN | 0386-3069 |
| 関連URL | http://www.e.okayama-u.ac.jp/gakkai/ |
| 言語 | 英語 |
| 著作権者 | Copyright © 2011 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 40018962706 |
| JaLCDOI | 10.18926/OER/47075 |
|---|---|
| タイトル（別表記） | Before and After the Merger of Municipalities: The Case of Okayama Prefecture |
| フルテキストURL | oer_043_2_001_027.pdf |
| 著者 | 中村 良平| 渡邊 喬| |
| 抄録 | This study concerns about before and after the merger of municipalities focusing on the case of Okayama Prefecture. By conducting questionnaire survey on municipalities, we examine the change of public service, tax burden, and resident consciousness. By expanding municipal areas it is becoming difficult to pick up needs of residents while some efficiency is attained by scale effects. Thus in order to overcome financial deficit and maintain public services it is quite important for all local municipalities to find out new basic industry for obtaining export money. |
| 出版物タイトル | 岡山大学経済学会雑誌 |
| 発行日 | 2011-09-26 |
| 巻 | 43巻 |
| 号 | 2号 |
| 開始ページ | 1 |
| 終了ページ | 27 |
| ISSN | 0386-3069 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2011 岡山大学経済学会 |
| 論文のバージョン | publisher |
| NAID | 40018962705 |
| 著者 | Nogami, Naoyuki| Hotta, Katsuyuki| Kuyama, Shoichi| Kiura, Katsuyuki| Takigawa, Nagio| Chikamori, Kenichi| Shibayama, Takuo| Kishino, Daizo| Hosokawa, Shinobu| Tamaoki, Akihiko| Harita, Shingo| Tabata, Masahiro| Ueoka, Hiroshi| Shinkai, Tetsu| Tanimoto, Mitsune| |
|---|---|
| 発行日 | 2011-10 |
| 出版物タイトル | Lung Cancer |
| 巻 | 74巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/47018 |
|---|---|
| フルテキストURL | 65_5_347.pdf |
| 著者 | Mukai, Takashi| Mimura, Hidefumi| Gobara, Hideo| Shimizu, Mitsuharu| Niiya, Harutaka| Kanazawa, Susumu| |
| 抄録 | We report herein the case of a 76-year-old woman with autosomal dominant polycystic kidney disease (ADPKD) and chronic renal failure resulting in intractable abdominal distension and anorexia. Computed tomography (CT) showed enlarged and cystic kidneys. We performed transcatheter arterial embolization (TAE) for renal arteries with ethanol. Absolute ethanol with iodinated contrast medium or Lipiodol was delivered into both renal arteries. The patient's low-grade fever subsided in 5 days, and no other complication occurred. The sensation of abdominal distension diminished approximately 1 month after embolization. A progressive decrease in kidney size was observed soon after embolization. The percentage of the decrement of kidney size was approximately 50% after 17 months. These results indicate that renal TAE with ethanol is a safe, cost-effective, and minimally invasive technique to reduce kidney size in symptomatic ADPKD patients. |
| キーワード | autosomal dominant polycystic kidney disease transcatheter arterial embolization ethanol |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 347 |
| 終了ページ | 351 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037273 |
| Web of Science KeyUT | 000296116400010 |
| JaLCDOI | 10.18926/AMO/47017 |
|---|---|
| フルテキストURL | 65_5_343.pdf |
| 著者 | Hara, Ryoei| Fujii, Tomohiro| Jo, Yoshimasa| Yokoyama, Teruhiko| Miyaji, Yoshiyuki| Nagai, Atsushi| |
| 抄録 | We report the case of a 7-year-old girl with a single ectopic ureter who was treated with retroperitoneoscopic nephrectomy for a chief complaint of urinary incontinence. Preoperative CT showed a contrasted dysplastic kidney of 1cm in the renal fossa and a left ureteral opening into the vagina. Retroperitoneoscopic left nephrectomy was conducted with opening of the lateroconal fascia to enable identification of the dysplastic kidney. No intraoperative complications were encountered. Urinary incontinence improved immediately after surgery. This case shows that a retroperitoneal approach can be used in nephrectomy if the position of the kidney can be determined preoperatively. |
| キーワード | dysplastic kidney nephrectomy retroperitoneal approach single ectopic ureter urinary incontinence |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 343 |
| 終了ページ | 345 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037272 |
| Web of Science KeyUT | 000296116400009 |
| JaLCDOI | 10.18926/AMO/47016 |
|---|---|
| フルテキストURL | 65_5_335.pdf |
| 著者 | Sakamoto, Yuichi| Mariya, Yasushi| Oshikiri, Toshiyuki| Sasaki, Sumiko| Segawa, Megumi| Teshiromori, Ryuichi| Ogura, Kazuto| Akagi, Tomoaki| Kaimori, Mitsuomi| Kubo, Kohmei| |
| 抄録 | Chronic myeloid leukemia (CML) is caused by the BCR-ABL oncogene. The Philadelphia chromosome (Ph) from a reciprocal translocation, t(9;22) (q34;q11) causes a fusion gene, BCR-ABL, that encodes a constitutively active tyrosine kinase. Treatment of CML by imatinib is effective to control the tyrosyl phosphorylation of the protein related to the cell signaling. BCR-ABL mRNA is overexpressed in the minimal residual disease (MRD), known as an early sign of relapse. Between December 2005 and June 2008, we measured BCR-ABL mRNA levels in the bone marrow (BM) from patients by quantitative real-time polymerase chain reaction (RQ-PCR) in Aomori Prefectural Central Hospital. Eighty-six samples from 26 patients were collected. Among the 26 CML patients, 11 patients (42%) were in the pretreatment group. Seven (64%) of the 11 patients achieved complete molecular response (CMR). In the post-treatment group consisting of the remaining 15 patients, 9 (60%) patients achieved CMR. The patients receiving imatinib at a dose over 300mg per day required 13 (6-77) months [median (range)] to achieve CMR. On the other hand, the patients receiving a dose below 300mg per day required 29.5 (11-84) months [median (range)]. When BCR-ABL mRNA was detected during the treatment course of patients with CMR, careful observation of BCR-ABL mRNA was useful for tracking the clinical course of patients. In conclusion, the BCR-ABL mRNA level was useful for monitoring the clinical course in 26 patients with CML. |
| キーワード | chronic myeloid leukemia (CML) BCR-ABL minimal residual disease (MRD) imatinib mesylate real-time quantitative PCR (RQ-PCR) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 335 |
| 終了ページ | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037271 |
| Web of Science KeyUT | 000296116400008 |
| JaLCDOI | 10.18926/AMO/47015 |
|---|---|
| フルテキストURL | 65_5_329.pdf |
| 著者 | Matsumoto, Yoshinori| Sada, Ken-ei| Takano, Mariko| Toyota, Noriko| Yamanaka, Ryutaro| Sugiyama, Koichi| Wakabayashi, Hiroshi| Kawabata, Tomoko| Otsuka, Fumio| Makino, Hirofumi| |
| 抄録 | It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age≧65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level≧2.0mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR＝4.50, 95%CI＝1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids. |
| キーワード | infection rheumatic disease glucocorticoids interstitial pneumonia risk factors |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 329 |
| 終了ページ | 334 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037270 |
| Web of Science KeyUT | 000296116400007 |
| JaLCDOI | 10.18926/AMO/47014 |
|---|---|
| フルテキストURL | 65_5_325.pdf |
| 著者 | Hu, Hai| Zhu, Jiang Fan| Huang, An Hua| Xin, Ying| Xu, An An| Chen, Bingguan| |
| 抄録 | To further improve our developed transumbilical endoscopic surgery (TUES), we developed a completely covert laparoscopic cholecystectomy (LC). Twelve cases of LC were recruited for this new approach. First, a 10-mm trocar was placed above the umbilicus for inserting the laparoscope. Two 5-mm trocars were then placed near the right and left ends of the superior margin of the suprapubic hair. After the 5-mm 30° laparoscope was shifted to the left suprapubic trocar, the harmonic scalper, electric hook, and grasper were inserted either through the 10-mm umbilical trocar or through the right suprapubic trocar. All gallbladders were successfully removed without intraoperative complications. The mean operating time was 28.5±5.7min (range 20-45min). All patients felt well after surgery and did not need postoperative analgesia. They resumed free oral intake 6h after the procedure. All patients were satisfied with the appearance of the incisions, which were completely hidden in the umbilicus and suprapubic hair. The approach we developed has overcome both external instrument interference around the umbilicus and the loss of triangulation in the operative field. It is relatively simpler than a typical TUES and offers better cosmetic results. |
| キーワード | laparoscopy cholecystectomy scarless surgery |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 325 |
| 終了ページ | 328 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037269 |
| Web of Science KeyUT | 000296116400006 |
| JaLCDOI | 10.18926/AMO/47013 |
|---|---|
| フルテキストURL | 65_5_315.pdf |
| 著者 | Wang, Lei| Kaku, Haruki| Huang, Peng| Xu, Kexin| Yang, Kai| Zhang, Jiheng| Li, Ming| Xie, Liping| Wang, Xiaofeng| Sakai, Akiko| Watanabe, Masami| Nasu, Yasutomo| Shimizu, Kenji| Kumon, Hiromi| Na, Yanqun| |
| 抄録 | Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare autosomal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of WRN Leu1074Phe (rs1801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN Leu1074Phe was genotyped by using a Snapshot assay. The results showed that WRN Leu1074Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR＝0.58, 95%CI:0.35-0.97, p＝0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <_ 72 yr (OR＝0.27, 95%CI:0.12-0.61, p＝0.002) and in patients with localized diseases (OR＝0.36, 95%CI:0.19-0.70, p＝0.003). However, no statistically significant difference was found in the subgroup with age ＞72 yr or in patients with advanced diseases. We concluded that the genetic variant Leu1074Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects. |
| キーワード | polymorphism prostatic neoplasms single nucleotide susceptibility WRN |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 315 |
| 終了ページ | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037267 |
| Web of Science KeyUT | 000296116400005 |
| JaLCDOI | 10.18926/AMO/47012 |
|---|---|
| フルテキストURL | 65_5_307.pdf |
| 著者 | Shiraki, Teruo| Saito, Daiji| |
| 抄録 | Factors contributing to the sex difference of in-hospital mortality after acute myocardial infarction (MI) are still unknown. We compared the clinical characteristics on admission and in-hospital outcome of consecutive 1,354 patients with acute MI between the 2 sexes. Age on admission was about 7 years older in women than in men. In-hospital death was significantly more frequent in women. Pulmonary congestion and hypertension were more likely in women with higher serum levels of total cholesterol and LDL cholesterol. A higher prevalence of current smoking and inferior wall involvement and lower serum HDL cholesterol level were observed in man. After adjusting for age, adverse in-hospital mortality for women was observed in both younger and older patients. Multivariate logistic regression analysis demonstrated that age, location of infarction, recanalization and serum C-reactive protein (CRP) concentration were independent predictors for in-hospital mortality for overall patients, while age and recanalization were independent predictors for male gender, and pulmonary congestion and serum CRP concentration were independent predictors for female gender. In-hospital outcome after acute MI was worse in women. A multivariate logistic regression model revealed that the sexually different factors affected in-hospital mortality in females. |
| キーワード | sex difference acute myocardial infarction inferior infarction in-hospital mortality age difference |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 307 |
| 終了ページ | 314 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037267 |
| Web of Science KeyUT | 000296116400004 |
| JaLCDOI | 10.18926/AMO/47011 |
|---|---|
| フルテキストURL | 65_5_299.pdf |
| 著者 | Itani, Miki| Yamamoto, Yuji| Doi, Yusuke| Miyaishi, Satoru| |
| 抄録 | Postmortem degradation of DNA was quantitatively estimated. Brain, liver, kidney and muscle samples were obtained from sacrificed rats left at 20℃ or 4℃. The quantity of DNA was measured by real-time PCR using a primer set for a sequence in the Rsrc 1 gene. When the quantity of amplified DNA using 10ng Human Genomic DNA was defined as 100 RFU, the quantities in the brain, liver, kidney and skeletal muscle (each 2μg of dry weight) on the day of sacrifice were 253±11, 338±22, 556±14 and 531±12 Relative Fluorescence Units (RFU), respectively (mean±S.E., n＝5). The quantity of amplified DNA decreased to below 10 RFU in 1-3 weeks in the liver, kidney and skeletal muscle at 20℃, while that in the brain was more than 10 RFU for six weeks, demonstrating the usefulness of the brain as a sample for DNA analysis of decaying corpses. It was suggested that quantifying the amplified DNA in the brain at 20℃ and in the liver at 4℃ as well as the ratio of the quantity of amplified DNA in the liver to the brain at 4℃ might be useful for diagnosing time of death. This study provides the first quantitative analysis of the postmortem progress of DNA degradation in the corpse. |
| キーワード | DNA degradation postmortem interval personal identification |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 299 |
| 終了ページ | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037266 |
| Web of Science KeyUT | 000296116400003 |
| JaLCDOI | 10.18926/AMO/47010 |
|---|---|
| フルテキストURL | 65_5_287.pdf |
| 著者 | Hiraki, Takao| Gobara, Hideo| Mimura, Hidefumi| Toyooka, Shinichi| Fujiwara, Hiroyasu| Yasui, Kotaro| Sano, Yoshifumi| Iguchi, Toshihiro| Sakurai, Jun| Tajiri, Nobuhisa| Mukai, Takashi| Matsui, Yusuke| Kanazawa, Susumu| |
| 抄録 | The application of radiofrequency ablation for the treatment of lung cancer by our group at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences began in June 2001, and in the present report, we review our 10-year experience with this treatment modality at Okayama University Hospital. The local efficacy of radiofrequency ablation for the treatment of lung cancer depends on tumor size and the type of electrode used, but not on tumor type. An important factor for the prevention of local failure may be the acquisition of an adequate ablative margin. The combination of embolization and radiation therapy enhances the local efficacy. Local failure may be salvaged by repeating the radiofrequency ablation, particularly in small tumors. Survival rates after radiofrequency ablation are quite promising for patients with clinical stage I non-small cell lung cancer and pulmonary metastasis from colorectal cancer, hepatocellular carcinoma, and renal cell carcinoma. The complications caused by radiofrequency ablation can be treated conservatively in the majority of cases. However, attention should be paid to rare but serious complications. This review shows that radiofrequency ablation is a promising treatment for patients with lung cancer. |
| キーワード | radiofrequency ablation lung cancer local efficacy survival complication |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 287 |
| 終了ページ | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037265 |
| Web of Science KeyUT | 000296116400002 |
| JaLCDOI | 10.18926/AMO/47009 |
|---|---|
| フルテキストURL | 65_5_279.pdf |
| 著者 | Miyoshi, Ko| Kasahara, Kyosuke| Miyazaki, Ikuko| Asanuma, Masato| |
| 抄録 | Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter primary cilium length. Renal injury is a well-known example of an environmental insult that triggers cilia length modification. Lithium treatment causes primary cilia to extend in several cell types including neuronal cells;this phenomenon is likely independent of glycogen synthase kinase-3β inhibition. In renal epithelial cell lines, deflection of the primary cilia by fluid shear shortens them by reducing the intracellular cyclic AMP level, leading to a subsequent decrease in mechanosensitivity to fluid shear. Primary cilium length is also influenced by the dynamics of actin filaments and microtubules through the levels of soluble tubulin in the cytosol available for primary cilia extension. Thus, mammalian cells can adapt to the extracellular environment by modulating the primary cilium length, and this feedback system utilizing primary cilia might exist throughout the mammalian body. Further investigation is required concerning the precise molecular mechanisms underlying the control of primary cilium length in response to environmental factors. |
| キーワード | primary cilium length lithium cyclic AMP soluble tubulin intraflagellar transport |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-10 |
| 巻 | 65巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 279 |
| 終了ページ | 285 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22037264 |
| Web of Science KeyUT | 000296116400001 |