検索結果 - 岡山大学学術成果リポジトリ

Influence of breast density on breast cancer risk: a case control study in Japanese women

フルテキストURL	K0006095_abstract_review.pdf K0006095_summary.pdf K0006095_fulltext.pdf
著者	西山慶子\|
発行日	2020-03-25
資料タイプ	学位論文
学位授与番号	甲第6095号
学位授与年月日	2020-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

「日本古代史研究の方法的模索－生存の問題を中心に－」

フルテキストURL	fulltext.pdf
著者	今津勝紀\|
発行日	2020-05
出版物タイトル	歴史科学
号	241号
開始ページ	22
終了ページ	35
資料タイプ	学術雑誌論文
言語	日本語
OAI-PMH Set	岡山大学
論文のバージョン	publisher

Analysis of Factors Associated With Radiation-Induced Bronchiolitis Obliterans Organizing Pneumonia Syndrome After Breast-Conserving Therapy

フルテキストURL	fulltext.pdf
著者	Katayama, Norihisa\| Sato, Shuhei\| Katsui, Kuniaki\| Takemoto, Mitsuhiro\| Tsuda, Toshihide\| Yoshida, Atsushi\| Morito, Tsuneharu\| Nakagawa, Tomio\| Mizutani, Akifumi\| Waki, Takahiro\| Niiya, Harutaka\| Kanazawa, Susumu\|
キーワード	Breast cancer Breast-conserving surgery Radiotherapy Radiation-induced BOOP syndrome Endocrine therapy
発行日	2009-03-15
出版物タイトル	International journal of radiation oncology, biology, physics
巻	73巻
号	4号
出版者	Elsevier
開始ページ	1049
終了ページ	1054
ISSN	0360-3016
NCID	AA00680920
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	18755559
DOI	10.1016/j.ijrobp.2008.05.050
Web of Science KeyUT	000264257400014
関連URL	isVersionOf https://doi.org/10.1016/j.ijrobp.2008.05.050

Predictive Factors of Rectal Toxicity After Permanent iodine-125 Seed Implantation: Prospective Cohort Study in 2339 Patients

フルテキストURL	fulltext2.pdf
著者	Katayama, Norihisa\| Yorozu, Atsunori\| Maruo, Shinichiro\| Kojima, Shinsuke\| Ohashi, Toshio\| Tanaka, Nobumichi\| Kikuchi, Takashi\| Higashide, Satoshi\| Saito, Shiro\| Dokiya, Takushi\| Fukushima, Masanori\| Yamanaka, Hidetoshi\|
キーワード	Brachytherapy Dose-volume histogram parameters External beam radiation therapy Interactive planning Prostate cancer Rectal toxicity
発行日	2016-10-05
出版物タイトル	Brachytherapy
巻	15巻
号	6号
出版者	Elsevier
開始ページ	736
終了ページ	745
ISSN	1538-4721
NCID	AA11694304
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	27720311
DOI	10.1016/j.brachy.2016.09.001
Web of Science KeyUT	000389864100009
関連URL	isVersionOf https://doi.org/10.1016/j.brachy.2016.09.001

Clinical Significance of Cytoplasmic IgE-Positive Mast Cells in Eosinophilic Chronic Rhinosinusitis

フルテキストURL	fulltext.pdf
著者	Gion, Yuka\| Okano, Mitsuhiro\| Koyama, Takahisa\| Oura, Tokie\| Nishikori, Asami\| Orita, Yorihisa\| Tachibana, Tomoyasu\| Marunaka, Hidenori\| Makino, Takuma\| Nishizaki, Kazunori\| Sato, Yasuharu\|
キーワード	mast cell eosinophilic chronic rhinosinusitis c-kit IgE
発行日	2020-03-07
出版物タイトル	International Journal of Molecular Sciences
巻	21巻
号	5号
出版者	MDPI
開始ページ	1843
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32155995
DOI	10.3390/ijms21051843
Web of Science KeyUT	000524908500294
関連URL	isVersionOf https://doi.org/10.3390/ijms21051843

Sensitive Photodynamic Detection of Adult T-cell Leukemia/Lymphoma and Specific Leukemic Cell Death Induced by Photodynamic Therapy: Current Status in Hematopoietic Malignancies

フルテキストURL	fulltext.pdf
著者	Oka, Takashi\| Matsuoka, Ken-Ichi\| Utsunomiya, Atae\|
キーワード	ATL HTLV-1 PDT PDD chemotherapy allogeneic hematopoietic cell transplantation immunotherapy GVHD ALA-PDT/PDD
発行日	2020-02-02
出版物タイトル	Cancers
巻	12巻
号	2号
出版者	MDPI
開始ページ	335
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32024297
DOI	10.3390/cancers12020335
Web of Science KeyUT	000522477300081
関連URL	isVersionOf https://doi.org/10.3390/cancers12020335

Retrotransposons Manipulating Mammalian Skeletal Development in Chondrocytes

フルテキストURL	fulltext.pdf
著者	Kubota, Satoshi\| Ishikawa, Takanori\| Kawata, Kazumi\| Hattori, Takako\| Nishida, Takashi\|
キーワード	retrotransposon endogenous retrovirus chondrocyte cartilage skeletal development
発行日	2020-02-25
出版物タイトル	International Journal of Molecular Sciences
巻	21巻
号	5号
出版者	MDPI
開始ページ	1564
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32106563
DOI	10.3390/ijms21051564
Web of Science KeyUT	000524908500015
関連URL	isVersionOf https://doi.org/10.3390/ijms21051564

Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma

フルテキストURL	fulltext.pdf
著者	Matsumoto, Yuji\| Ichikawa, Tomotsugu\| Kurozumi, Kazuhiko\| Otani, Yoshihiro\| Fujimura, Atsushi\| Fujii, Kentaro\| Tomita, Yusuke\| Hattori, Yasuhiko\| Uneda, Atsuhito\| Tsuboi, Nobushige\| Kaneda, Keisuke\| Makino, Keigo\| Date, Isao\|
キーワード	ANXA2 OSMR Invasion Mesenchymal transition Glioblastoma
発行日	2020-04-05
出版物タイトル	Acta Neuropathologica Communications
巻	8巻
号	1号
出版者	BMC
開始ページ	42
ISSN	2051-5960
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	32248843
DOI	10.1186/s40478-020-00916-7
Web of Science KeyUT	000524286500001
関連URL	isVersionOf https://doi.org/10.1186/s40478-020-00916-7

Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells

フルテキストURL	fulltext.pdf
著者	Hassan, Ghmkin\| Afify, Said M.\| Nair, Neha\| Kumon, Kazuki\| Osman, Amira\| Du, Juan\| Mansour, Hager\| Abu Quora, Hagar A.\| Nawara, Hend M.\| Satoh, Ayano\| Zahra, Maram H.\| Okada, Nobuhiro\| Seno, Akimasa\| Seno, Masaharu\|
キーワード	Induced pluripotent stem cells Cancer stem cells differentiation tumor microenvironment hematopoietic cells
発行日	2019-12-29
出版物タイトル	Cancers
巻	12巻
号	1号
出版者	MDPI
開始ページ	82
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 by the authors.
論文のバージョン	publisher
PubMed ID	31905766
DOI	10.3390/cancers12010082
Web of Science KeyUT	000516826700082
関連URL	isVersionOf https://doi.org/10.3390/cancers12010082

Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3

フルテキストURL	fulltext.pdf
著者	Sogawa, Chiharu\| Eguchi, Takanori\| Tran, Manh Tien\| Ishige, Masayuki\| Trin, Kilian\| Okusha, Yuka\| Taha, Eman Ahmed\| Lu, Yanyin\| Kawai, Hotaka\| Sogawa, Norio\| Takigawa, Masaharu\| Calderwood, Stuart K.\| Okamoto, Kuniaki\| Kozaki, Ken-Ichi\|
キーワード	drug repositioning/repurposing three-dimensional (3D) culture tumoroids dopamine transporter (DAT) benztropine signal transducer and activator of transcription (STAT) circulating tumor cell (CTC)
発行日	2020-02-24
出版物タイトル	Cancers
巻	12巻
号	2号
出版者	MDPI
開始ページ	523
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32102440
DOI	10.3390/cancers12020523
Web of Science KeyUT	000522477300269
関連URL	isVersionOf https://doi.org/10.3390/cancers12020523

Conventional versus Rapid Glucocorticoid Tapering in Severe Systemic Lupus Erythematosus Patients: A Non-Blind, Randomized Controlled Trial

JaLCDOI	10.18926/AMO/58279
フルテキストURL	74_2_179.pdf
著者	Abe, Yoshiyuki\| Fujibayashi, Kazutoshi\| Nishizaki, Yuji\| Yanagisawa, Naotake\| Nojiri, Shuko\| Kon, Takayuki\| Tada, Kurisu\| Yamaji, Ken\| Tamura, Naoto\|
抄録	Glucocorticoids (GCs) have long played a central role in the treatment of systemic lupus erythematosus (SLE), but these drugs have many adverse effects. We will determine whether rapid weekly GC tapering is non-inferior to conventional biweekly tapering in patients with severe SLE. This is a randomized, open-label, multicenter controlled trial. The primary outcome is the relapse-free survival rate at 52 weeks. The main secondary outcome is the prevalence of the Lupus Low Disease Activity State at 52 weeks. The trial will determine the optimal method of tapering GCs in patients with severe SLE.
キーワード	systemic lupus erythematosus relapse-free survival rate glucocorticoid, tapering Lupus Low Disease Activity State
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	179
終了ページ	183
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341595
Web of Science KeyUT	000528278500014
NAID	120006839458

Percutaneous Nephrolithotomy under Local Infiltration Anesthesia in Kneeling Prone Position for a Patient with Spinal Deformity

JaLCDOI	10.18926/AMO/58278
フルテキストURL	74_2_175.pdf
著者	Yu, Zhikang\| Lin, Wenfeng\| Xu, Abai\| Liu, Chunxiao\| Li, Hulin\| Huang, Peng\|
抄録	Urolithiasis, a common condition in patients with spinal deformity, poses a challenge to surgical procedures and anesthetic management. A 51-year-old Chinese male presented with bilateral complex renal calculi. He was also affected by severe kyphosis deformity and spinal stiffness due to ankylosing spondylitis. Dr. Li performed the percutaneous nephrolithotomy under local infiltration anesthesia with the patient in a kneeling prone position, achieving satisfactory stone clearance with no severe complications. We found this protocol safe and effective to manage kidney stones in patients with spinal deformity. Local infiltration anesthesia may benefit patients for whom epidural anesthesia and intubation anesthesia are difficult.
キーワード	percutaneous nephrolithotomy local infiltration anesthesia kneeling prone position spinal deformity
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	175
終了ページ	178
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341594
Web of Science KeyUT	000528278500013
NAID	120006839457

Incarcerated Amyand’s Hernia

JaLCDOI	10.18926/AMO/58277
フルテキストURL	74_2_171.pdf
著者	Okita, Atsushi\| Yoshida, Osamu\| Murakami, Masakazu\|
抄録	A 76-year-old Japanese man was transferred to our hospital to undergo rehabilitation after traffic accident-related injuries. Seven days post-admission, he presented with abdominal pain and an 8-cm lump in the right inguinal region. He was diagnosed with an incarcerated inguinal hernia and underwent elective surgery the day after manual reduction. He had a normal vermiform appendix which was observed to have adhered to the right indirect hernia sac. An appendectomy and hernia repair using lightweight mesh were performed. We discuss the surgical management of this rare incarcerated Amyand’s hernia and the relevant literature.
キーワード	Amyand’s hernia incarcerated inguinal hernia appendectomy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	171
終了ページ	174
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341593
Web of Science KeyUT	000528278500012
NAID	120006839456

Identification of a Novel ACVRL1 Gene Mutation (c.100T>A, p.Cys34Ser) in a Japanese Patient with Possible Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Disease)

JaLCDOI	10.18926/AMO/58276
フルテキストURL	74_2_165.pdf
著者	Umemura, Hiroshi\| Miura, Katsuhiro \| Naruse, Hiromu\| Hatta, Yoshihiro\| Takei, Masami\| Nakayama, Tomohiro\|
抄録	Hereditary hemorrhagic telangiectasia (HHT; also known as Osler-Weber-Rendu disease) is an autosomal dominant genetic disorder that causes frequent epistaxis, mucocutaneous telangiectasia, and visceral arteriovenous malformations. Four genes (ENG, ACVRL1, SMAD4, and GDF2) have been identified as pathogenic in HHT. We describe the case of a 50-year-old Japanese man highly suspected of having HHT due to recurrent epistaxis, mucocutaneous telangiectasia, and a family history. Genomic analysis revealed a novel missense mutation of c.100T>A, p.Cys34Ser in the patient’s ACVRL1 gene. We used 6 freeware programs to perform an in silico analysis of this mutation. The results demonstrated the mutation’s high pathogenicity.
キーワード	ACVRL1 hereditary hemorrhagic telangiectasia in silico analysis missense mutation Osler-Weber- Rendu disease
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	165
終了ページ	169
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341592
Web of Science KeyUT	000528278500011
NAID	120006839455

Juvenile Granulosa Cell Tumor with an Unusual Clinical Course: A Late-onset and Late Recurrent Case

JaLCDOI	10.18926/AMO/58275
フルテキストURL	74_2_159.pdf
著者	Thar Htet San\| Ota, Yoko\| Fushimi, Soichiro\| Fujisawa, Masayoshi\| Yanai, Hiroyuki\| Toda, Hiroko\| Kunitomo, Tadayoshi\| Kodama, Keisuke\| Matsukawa, Akihiro\|
抄録	Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (～97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.
キーワード	juvenile granulosa cell tumor late recurrence adult granulosa cell tumor
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	159
終了ページ	163
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341591
Web of Science KeyUT	000528278500010
NAID	120006839454

Non-traumatic Atypical Peri-implant Femoral Fracture at the Distal Screw after Short Femoral Nail Fixation for a Pertrochanteric Fracture

JaLCDOI	10.18926/AMO/58274
フルテキストURL	74_2_151.pdf
著者	Yamamoto, Norio\| Dan’ura, Tomoyuki\| Noda, Tomoyuki\| Ozaki, Toshifumi\|
抄録	This is the second report of an atypical peri-implant femoral fracture occurring at the distal screw after intramedullary nail fixation of a pertrochanteric fracture. A 94-year-old Japanese female with a 5-year history of alendronate intake presented with prodromal pain in her right thigh after intramedullary nail fixation. Plain radiographs showed an incomplete noncomminuted transverse fracture at the distal screw, suggesting an atypical peri-implant femoral fracture. The pathogenesis of an atypical peri-implant femoral fracture could be a combined systemic bone metabolism disorder and repetitive overloading at the screw, similar to the pathogenesis of an atypical periprosthetic femoral fracture around stem implantation.
キーワード	atypical femoral fracture insufficiency fracture bisphosphonate atypical peri-implant femoral fracture, atypical periprosthetic femoral fracture
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	151
終了ページ	157
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341590
Web of Science KeyUT	000528278500009
NAID	120006839453

The Efficacy of Mirabegron for the Relief of Ureteral Stent-Related Symptoms

JaLCDOI	10.18926/AMO/58273
フルテキストURL	74_2_145.pdf
著者	Otsuki, Hideo\| Yamasaki, Tomoya\| Hori, Shunsuke\| Aoki, Hiroshi\| Kosaka, Takeo\| Uehara, Shinya\| Fujio, Kei\|
抄録	To investigate the efficacy of mirabegron for lower urinary tract symptoms in patients with an indwelling ureteral stent after ureterorenoscopic lithotripsy. This was a prospective follow-up study of 76 patients with stent-related symptoms (SRSs). Patients with upper urinary calculi who were pre-stented for > 2 weeks before lithotripsy were examined for the presence of SRSs by tests including the International Prostate Symptom Score (IPSS), OAB Symptom Score (OABSS), and urinary bother and pain measured by a Visual Analogue Scale (VAS) before lithotripsy. Mirabegron (50 mg/day) was prescribed post-lithotripsy for 2 weeks. SRSs were assessed at the time of stent removal. The IPSS scores improved significantly from 16.2 to 14.3 (p<0.001) and the IPSS-QoL scores decreased significantly from 5.0 to 4.6 (p=0.012). The OABSS scores improved significantly from 7.7 to 6.8 (p=0.006), and the urinary urgency scores (OABSS-Q3) decreased significantly from 3.24 to 2.68 (p<0.001). The number of nocturia episodes decreased significantly from 2.5 to 2.2 (p=0.045). Urinary bother and pain assessed by the VAS declined from 4.2 and 3.1 to 3.8 (p=0.15) and 2.5 (p=0.075), respectively. Mirabegron significantly improved SRSs and the number of nocturia episodes due to a ureteral stent.
キーワード	stent-related symptoms overactive bladder mirabegron ureterorenoscopic lithotripsy ureteral stent
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	145
終了ページ	150
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341589
Web of Science KeyUT	000528278500008
NAID	120006839452

Mucinous Carcinoma of the Breast: Clinicopathological Features and Long-term Prognosis in Comparison with Invasive Ductal Cancer; A Single Hospital’s 30+-Year Experience

JaLCDOI	10.18926/AMO/58272
フルテキストURL	74_2_137.pdf
著者	Isozaki, Hiroshi\| Yamamoto, Yasuhisa\| Sakai, Kunihiko\| Sho, Tatuo\| Ishihara, Kiyohiro\| Murakami, Shigeki\| Matsumoto, Sasau\| Takama, Takehiro\|
抄録	Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer.
キーワード	breast cancer mucinous carcinoma clinicopathological features long-term prognosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	137
終了ページ	143
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341588
Web of Science KeyUT	000528278500007
NAID	120006839451

Association between Histological Types and Enhancement of Dynamic CT for Primary Lung Cancer

JaLCDOI	10.18926/AMO/58271
フルテキストURL	74_2_129.pdf
著者	Fukuma, Shogo\| Shinya, Takayoshi\| Soh, Junichi\| Fukuhara, Ryuichiro\| Ogawa, Nanako\| Higaki, Fumiyo\| Tanaka, Takehiro\| Ichihara, Eiki\| Hiraki, Takao\| Toyooka, Shinichi\| Kanazawa, Susumu\|
抄録	The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal–Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types.
キーワード	differentiation dynamic computed tomography primary lung cancer enhancement pattern
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	129
終了ページ	135
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341587
Web of Science KeyUT	000528278500006
NAID	120006839450

The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma

JaLCDOI	10.18926/AMO/58270
フルテキストURL	74_2_123.pdf
著者	Fukuhara, Ryuichiro\| Shinya, Takayoshi\| Fukuma, Shogo\| Ogawa, Nanako\| Masaoka, Yoshihisa\| Tanaka, Takehiro\| Marunaka, Hidenori\| Arioka, Tadashi\| Hiraki, Takao\| Kaji, Mitsumasa\| Kanazawa, Susumu\|
抄録	The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly.
キーワード	18F-fluorodeoxyglucose positron emission tomography/computed tomography extranodular spread metastasis oral squamous cell carcinoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	123
終了ページ	128
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341586
Web of Science KeyUT	000528278500005
NAID	120006839449