検索結果 1369 件
| JaLCDOI | 10.18926/AMO/30307 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Taniguchi, Miyabi| Hosaki, Yasuhiro| Ubuka, Toshihiko| |
| 抄録 | Transaminative metabolism of L-cysteine was investigated using homogenates of guinea pig liver and kidney. L-Cysteine was transaminated in the presence of 2-oxoglutarate and the homogenate of either liver or kidney. S-(2-Hydroxy-2-carboxyethylthio)cysteine (HCETC) (3-mercaptolactate-cysteine disulfide) was formed by liver homogenate, but the amount was very small. On the other hand, a relatively large amount of HCETC was formed in the presence of kidney homogenate. Transamination between 3-mercaptopyruvate and certain amino acids was catalyzed actively by both liver and kidney homogenates in the presence of L-glutamate. However, more half-cysteine was formed by liver than kidney, and more HCETC was produced by kidney than liver. L-Glutamate was the most potent amino donor, and L-aspartate strongly inhibited the reaction. Results indicate that L-cysteine can be transaminated both in liver and kidney of the guinea pig, and that kidney is more active than liver. 2-Oxoglutarate is the most active 2-oxo acid for cysteine transamination. Oxaloacetate (and aspartate in the reverse reaction) is inhibitory to the reaction. These results are in agreement with the previous conclusion that cysteine aminotransferase is identical with aspartate aminotransferase. |
| キーワード | cysteine transamination guinea pig mercaptopyruvate mercaptolactate-cysteine disulfide |
| Amo Type | Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 1984-08 |
| 巻 | 38巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 375 |
| 終了ページ | 380 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 6496171 |
| Web of Science KeyUT | A1984TG25900007 |
| 著者 | ペトゥロビッチ アナマリヤ| |
|---|---|
| 発行日 | 2010-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| JaLCDOI | 10.18926/21206 |
|---|---|
| タイトル（別表記） | Study of metabolism of uric acid. (1) Observation of uric acid values |
| フルテキストURL | 046_061_070.pdf |
| 著者 | 青木 宏子| |
| 抄録 | Uric acid was measured in serum and urine of the ambulant and hospitalized patients with various disorders including gout. in Misasa-Branch Hospital of Okayama University Medical School from January 1975 to December 1976. Serum and urine samples were obtained from 283 males and 260 females, and from 2 males respectively. The results are as follws; (1) Uric acid in males was 1.4 mg/100mf higher than in females. (2) Uric acid in males decreased with ages, showing two peaks between 15 and19 , and between 35 and 44 years old. (3) Uric acid in females showed low levels between third and fifth decades and increased thereafter with ages. (4) There were many fatty subjects among the patients with gout. (5) An increase in total daily excretion of urinary uric acid was observed concomitantly with increased daily urine volume. (6) Periodical fluctuations of uric acid in serum and other clinical findings were show in several cases of gout, who had been controlled in MisasaBranch Hospital for several years. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1977-03-25 |
| 巻 | 46巻 |
| 開始ページ | 61 |
| 終了ページ | 70 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002311005 |
| JaLCDOI | 10.18926/21152 |
|---|---|
| タイトル（別表記） | Changes in plasma metabolites after the injection of noradrenalin -effect of hot spring serial bathing- |
| フルテキストURL | pitsr_051_053_056.pdf |
| 著者 | 妹尾 敏伸| |
| 抄録 | In attempt to clarify the effect of serial bathing on metabolic actions of noradrenaline (NA) by using rats which took a bath (for 10 minutes, 40℃ in temperature) in the hot spring in Misasa or a city water once daily for one and four weeks, changes in plasma metabolites after the injection of NA (20μg/100g, subcutaneously) were studied. No significant difference in the rising degree of plasma free fatty acid (FFA) or glucose levels by NA injection was observed in rats which took serial bathing for one week, while triglyceride levels of rats, which took a city water bath, rised significantly by NA in jection. After serial bathing for four weeks, however, remarkable difference in the rising degree of FFA levels by NA injection was observed between rats taking a city water bath and ones taking hot spring bath and between rats taking a bath and non-treated ones. The rising degree of glucose levels by NA injection was slightly supressed only in rats taking a city water bath compared with nontreated rats. Little difference in the rising degree of β-hydroxybutyrate levels by NA injection was observed in rats taking serial bathing for one or four weeks compared with non-treated rats. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1981-03-25 |
| 巻 | 51巻 |
| 開始ページ | 53 |
| 終了ページ | 56 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002310994 |
| JaLCDOI | 10.18926/21136 |
|---|---|
| タイトル（別表記） | Attention to the Developmental Aspect Part I. Female Adolescent Cases of Anorexia Nervosa |
| フルテキストURL | 052_033_037.pdf |
| 著者 | 古元 順子| |
| 抄録 | The author reviewed 55 patients who had been treated as anorexia nervosa at the neuropsychiatric department of Okayama University Medical School and at the internal medicine department of Misasa Branch Hospital, Okayama University Medical School, for the past ten years from 1970 to 1980. The criteria for the present study was as follows; 1) absence of psychosis and no known physical illness for ematiation, 2) weight loss of at least 2096 of original body weight, 3) duration of anorexia of at least three months. 55 patients were classified into three groups according to the age of onset ; pre-puberty group. adolescent group and adult group. Analysis of two female adolescent cases was described in this report for the preliminary study. The results were as follows : 1) Onset of self-starvation coincided with competitious hyperactivity in sport and/or study. Self-starvation seemed to have psychological meaning of retaliation towards the mother of each patient, of compensatory gain in the dependancy need. and of keeping a pride in pubertal competitions including a pursuit in the slim body image. 2) There was the evidence of a disturbed female-identification which originated from the disturbed mother-child interaction. 3) Catharsis with analytically oriented psychotherapy improved gastro-intestinal disorders such as anorexia and constipation and reversed the negative BMR (basal metabolic rate) to the positive BMR. Recovery of menstrual periods was followed in an accordance with re-gain of the original body weight. |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1982-03-25 |
| 巻 | 52巻 |
| 開始ページ | 33 |
| 終了ページ | 37 |
| ISSN | 0369-7142 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40000321162 |
| 著者 | 藤岡 由五| |
|---|---|
| 発行日 | 1956-11-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 11号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 藤岡 由五| |
|---|---|
| 発行日 | 1956-11-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 11号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 藤岡 由五| |
|---|---|
| 発行日 | 1956-11-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 11号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 広瀬 温| |
|---|---|
| 発行日 | 1956-11-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 11号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 水田 勝| |
|---|---|
| 発行日 | 1956-10-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 10号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 水田 勝| |
|---|---|
| 発行日 | 1956-10-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 10号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 水田 勝| |
|---|---|
| 発行日 | 1956-10-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 10号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 小林 正| |
|---|---|
| 発行日 | 1956-09-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 9号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 小林 正| |
|---|---|
| 発行日 | 1956-09-30 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 9号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/19771 |
|---|---|
| タイトル（別表記） | トランスフェリンを介する鉄の細胞内取り込み機序 ―特に肝細胞への取り込みにおける内皮細胞の関与について― |
| フルテキストURL | 059_083_092.pdf |
| 著者 | 入江 誠治| 松本 秀次| 越智 浩二| 武田 正彦| 田中 淳太郎| 原田 英雄| Mehdi, Tavassoli| |
| 抄録 | Transferrin (Tf) is thought to play a pivotal role in iron metabolism of various kinds of cells. Tf has specific receptors on the surface of the cells that require iron. Tf-receptor binding is followed by internalization through a system of coated pits and vesicles. The rapid decline of pH of these vesicles leads to the release and sequestration of iron by the cell. Apotransferrin-receptor complex returns to the cell surface, where under neutral pH conditions, apotransferrin is dissociated from the receptor. Recent advances in cellular and molecular biology, gene cloning and monoclonal antibody technique have elucidated many features of these processes at a molecular level. These advances are briefly reviewed, and particularly, our own observations concerning endothelial mediation of uptake of Tf by hepatocytes are discussed. |
| キーワード | Iron uptake (鉄の細胞内取り込み) Transferrin (トランスフェリン) Receptor-Mediated Endocytosis Desialation (脱シアル化) Endothelium (内皮細胞) |
| 出版物タイトル | 環境病態研報告 |
| 発行日 | 1988-08 |
| 巻 | 59巻 |
| 開始ページ | 83 |
| 終了ページ | 92 |
| ISSN | 0913-3771 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120002309113 |
| JaLCDOI | 10.18926/19770 |
|---|---|
| タイトル（別表記） | Etiology and pathogenesis of chronic pancreatitis |
| フルテキストURL | 059_068_082.pdf |
| 著者 | 原田 英雄| 松本 秀次| 越智 浩二| 武田 正彦| 妹尾 敏伸| 入江 誠治| 田中 淳太郎| |
| 抄録 | 慢性膵炎の成因の主たるものは，アルコール性，特発性，胆石性である。病態面では，社会的・家庭的にもっとも責任が重い壮年期に頑固な疼痛，消化吸収障害，二次性糖尿病のために生活の質が低下することが問題になる。経過中に併発してくる膵およびそのほかの臓器の癌，および糖尿病の合併症による死亡も少なくない。アルコール性慢性膵炎の初期病変の発生機序としては，①膵過分泌の結果として細膵管内に形成される蛋白栓による膵液流出障害と，②蛋白栓あるいはアルコールの直接障害作用による細膵管上皮の損傷，およびその結果生じる膵管狭窄による膵液流出障害が注目されている。膵液流出障害はその上流域に実質細胞の破壊と間質の線維化をおこす。膵液には多くの生化学的異常が認められ，いったん発生した膵管の構造異常とあいまって慢性膵炎進展の原因となる。素因および栄養のアンバランスは発症，進展の促進因子となる。発症を予防し，進展を阻止する手段を開発するためには素因および飲酒・食事を含む環境因子の解析が今後の重要な課題である。 |
| キーワード | 慢性膵炎 (Chronic pancreatitis) 成因 (Etiology) 発生機序 (Pathogenesis) |
| 出版物タイトル | 環境病態研報告 |
| 発行日 | 1988-08 |
| 巻 | 59巻 |
| 開始ページ | 68 |
| 終了ページ | 82 |
| ISSN | 0913-3771 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002308982 |
| JaLCDOI | 10.18926/19621 |
|---|---|
| タイトル（別表記） | STUDIES ON BALNEOTHERAPY OF DIABETES MELLITUS (Ⅰ). EFFECT OF THE RADIOACTIVE THERMAL BATH UPON THE CARBOHYDRATE METABOLISM AND THE LEUCOCYTE PICTURE IN ALLOXAN-DIABETIC RABBITS. |
| フルテキストURL | 015_034_047.pdf |
| 著者 | 森永 寛| |
| 抄録 | The author investigated the effect of the radioactive thermal bath upon the carbohydrate metabolism and the leucocyte picture in alloxan-diabetic rabbits. 1. The author injected 100-200 mg. of alloxan per kg. of body weight intravenously into normal rabbits and produced alloxan diabetes. The triphasic blood sugar response to the injection of alloxan is illustrated in Table 1. and Fig. 1. About a week after the injection of alloxan, the fasting blood sugar values ranged 127 to 331 mg./dl. (Table 3.). 2. In this experiment the alloxan-diabetic rabbits were put in radioactive hot spring and plain water bath, 42-44℃. in temperature. The radioactive hot springs put in use are "Hisui-no-Yu" and "Kenkyusho-sen" (the Loboratory-Spring), both in Misasa Spa, the chemical compositions of which are given in Table 2. 3. In any case, the blood sugar level rose temporarily after the thermal baths for 5 minutes, but the 24-hour blood sugar value after taking a bath was lower in "Hisui-no-Yu" (Rn: 300-400 Mache units) than in "Kenkyusho-sen" (Rn: 10-30 Mache units) (Table 3 and Fig. 2). 4. The glucose tolerance was found to be abnormal in alloxan-diabetic rabbits even 3 months after the injection of alloxan, but this abnormal carbohydrate metabolism tended to become normal by the radioactive thermal bath (Table 5, 6 and Fig. 3, 5.). 5. The radioactive thermal bath in "Hisui-no-Yu" caused increase of leucocyte counts of alloxan-diabetic rabbits more remarkably than the bath in "Kenkyusho-sen" (Table 8. and Fig. 6). |
| 出版物タイトル | 岡山大学温泉研究所報告 |
| 発行日 | 1955-03-25 |
| 巻 | 15巻 |
| 開始ページ | 34 |
| 終了ページ | 47 |
| ISSN | 0369-7142 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/21510 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120002314143 |
| 著者 | 大橋 亘| |
|---|---|
| 発行日 | 1956-08-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 8号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大橋 亘| |
|---|---|
| 発行日 | 1956-08-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 8号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 大橋 亘| |
|---|---|
| 発行日 | 1956-08-31 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 68巻 |
| 号 | 8号 |
| 資料タイプ | 学術雑誌論文 |