検索結果 - 岡山大学学術成果リポジトリ

Clinicopathological Features and Outcomes of Endoscopic Submucosal Dissection for Superficial Cancer of the Pharynx

JaLCDOI	10.18926/AMO/56646
フルテキストURL	73_2_109.pdf
著者	Abe, Makoto\| Iwamuro, Masaya\| Kawahara, Yoshiro\| Kanzaki, Hiromitsu\| Kawano, Seiji\| Tanaka, Takehiro\| Tsumura, Munechika\| Makino, Takuma\| Noda, Yohei\| Marunaka, Hidenori\| Nishizaki, Kazunori\| Okada, Hiroyuki\|
抄録	The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. “Resect and watch” is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.
キーワード	endoscopic submucosal dissection superficial cancer pharynx endoscopic resection
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-04
巻	73巻
号	2号
出版者	Okayama University Medical School
開始ページ	109
終了ページ	115
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31015745

Cluster analysis using anti-aminoacyl-tRNA synthetases and SS-A/Ro52 antibodies in patients with polymyositis/dermatomyositis

フルテキストURL	K0005859_abstract_review.pdf K0005859_summary.pdf K0005859_fulltext.pdf
著者	大橋敬司\|
発行日	2018-12-27
資料タイプ	学位論文
学位授与番号	甲第5859号
学位授与年月日	2018-12-27
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Efficacy of Oral Care Provided by Interprofessional Collaboration for a Patient with Esophageal Cancer Associated with Post-polio Syndrome during Neoadjuvant Chemotherapy

JaLCDOI	10.18926/AMO/56461
フルテキストURL	73_1_71.pdf
著者	Takahashi-Arimasa, Keiko\| Kohno-Yamanaka, Reiko\| Soga, Yoshihiko\| Miura, Rumi\| Morita, Manabu\|
抄録	Preoperative oral care is helpful to prevent postoperative complications in patients who are undergoing esophagectomy. Here, we report the case of an 81-year-old Japanese man with an upper limb disability caused by post-polio syndrome who was receiving neoadjuvant chemotherapy for esophageal cancer. He had poor oral health status and developed oral complications as a side effect of chemotherapy. He could not brush his teeth by himself. However, infection control by oral care provided by an interprofessional collaboration successfully improved his oral hygiene, and his follow-up involved no severe complications. Interprofessional collaboration is useful especially for patients with upper limb disability.
キーワード	esophageal cancer preoperative oral care post-polio syndrome neoadjuvant chemotherapy oral mucositis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	71
終了ページ	76
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820057

Predictive Factors for Successful Vaccination Against Hepatitis B Surface Antigen in Patients Who Have Undergone Orthotopic Liver Transplantation

JaLCDOI	10.18926/AMO/56457
フルテキストURL	73_1_43.pdf
著者	Ikeda, Ailee\| Takaki, Akinobu\| Yasunaka, Tetsuya\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Onishi, Hideki\| Ikeda, Fusao\| Shiraha, Hidenori\| Yoshida, Kazuhiro\| Kuise, Takashi\| Nobuoka, Daisuke\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Fujiwara, Toshiyoshi\| Okada, Hiroyuki\|
抄録	Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. A positive anti-hepatitis B surface antibody response was achieved in 29% (8/28) of the LC-B group, 88% (7/8) of the ALF-B group, and 44% (4/9) of the adult non-B ESLD group. All four non-B ESLD infants showed vaccine success. The predictive factors for a good response in LC-B were young age, marital donor, and high donor age. ALF-B and non-B ESLD infants are thus good vaccination candidates. LC-B patients with marital donors are also good candidates, perhaps because the donated liver maintains an efficient immune memory to HBV, as the donors had already been infected in adulthood and showed adequate anti-HBV immune responses.
キーワード	acute liver failure hepatitis B hepatitis B vaccine liver cirrhosis liver transplantation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	41
終了ページ	50
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820053

The Role of Kallikrein-Related Peptidases in Atopic Dermatitis

JaLCDOI	10.18926/AMO/56452
フルテキストURL	73_1_1.pdf
著者	Morizane, Shin\|
抄録	Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD.
キーワード	atopic dermatitis kallikrein-related peptidases epidermal barrier dysfunction
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2019-02
巻	73巻
号	1号
出版者	Okayama University Medical School
開始ページ	1
終了ページ	6
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30820048

Computed Tomography Findings for Diagnosing Follicular Thyroid Neoplasms

JaLCDOI	10.18926/AMO/56375
フルテキストURL	72_6_577.pdf
著者	Makino, Takuma\| Orita, Yorihisa\| Tachibana, Tomoyasu\| Marunaka, Hidenori\| Miki, Kentaro\| Akisada, Naoki\| Akagi, Yusuke\| Usui, Yoshiyuki\| Sato, Yasuharu\| Yoshino, Tadashi\| Nishizaki, Kazunori\|
抄録	Since no diagnostic method has been established to distinguish follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA), surgery has been the only way to reach a diagnosis of follicular neoplasm. Here we investigated the computed tomography (CT) features of follicular neoplasms, toward the goal of being able to identify specific CT features allowing the preoperative differentiation of FTC from FTA. We retrospectively analyzed the cases of 205 patients who underwent preoperative CT of the neck and were histopathologically diagnosed with FTC (n=31) or FTA (n=174) after surgery between January 2002 and June 2016 at several hospitals in Japan. In each of these 205 cases, non-enhanced and contrast-enhanced CT images were obtained, and we analyzed the CT features. On univariate analysis, inhomogeneous features of tumor lesions on contrast-enhanced CT were more frequently observed in FTC than in FTA (p=0.0032). A multivariate analysis identified inhomogeneous features of tumor lesions on contrast-enhanced CT images as an independent variable indicative of FTC (p=0.0023). CT thus offers diagnostic assistance in distinguishing FTC from FTA.
キーワード	computed tomography follicular thyroid carcinoma follicular thyroid adenoma preoperative diagnosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-12
巻	72巻
号	6号
出版者	Okayama University Medical School
開始ページ	577
終了ページ	581
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30573912
NAID	120006545160

Prognostic Factors for Pediatric Living Donor Liver Transplantation: Impact of Zero-mortality Transplant for Cholestatic Diseases

JaLCDOI	10.18926/AMO/56374
フルテキストURL	72_6_567.pdf
著者	Yagi, Takahito\| Takagi, Kosei\| Umeda, Yuzo\| Yoshida, Ryuichi\| Nobuoka, Daisuke\| Kuise, Takashi\| Fujiwara, Toshiyoshi\|
抄録	Living donor liver transplantation (LDLT) is the final therapeutic arm for pediatric end-stage liver diseases. Toward the goal of achieving further improvement in LDLT survival, we investigated factors affecting recipient survival. We evaluated the prognostic factors of 60 pediatric recipients (< 16 years old) who underwent LDLT between 1997 and 2015. In a univariate analysis, non-cholestatic (NCS) disease, graft/recipient body weight ratio, cold and warm ischemic times, and intraoperative blood loss were significant factors impacting survival. In a multivariate analysis, NCS disease was the only significant factor worsening survival (p=0.0021). One-and 5-year survival rates for the cholestatic disease (CS, n=43) and NCS (n=17) groups were 100% vs. 70.6% and 97.4% vs. 58.8% (p=0.004, log-rank). Intergroup comparisons revealed that CS was significantly associated with operation time, cold ischemia, hepatomegaly of the native liver, and portal plasty. These data suggest that a cirrhotic, swollen, artery-dominant liver did not increase graft size-related risks despite the surgical complexity of preceding operations. The NCS group’s poorer survival originated from recurrence of the primary disease and liver manifestation of systemic disease untreatable by transplantation. Improving the survival of pediatric recipients requires intensive efforts to prevent primary disease relapse and more rapid diagnoses to exclude contraindications from NCS disease.
キーワード	liver transplantation living donor pediatrics prognostic factor cholestatic disease
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-12
巻	72巻
号	6号
出版者	Okayama University Medical School
開始ページ	567
終了ページ	576
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30573911
NAID	120006545159

Dose-Volume Parameters Predict Radiation Pneumonitis after Surgery with Induction Concurrent Chemoradiotherapy for Non-small Cell Lung Cancer

JaLCDOI	10.18926/AMO/56249
フルテキストURL	72_5_507.pdf
著者	Ogata, Takeshi\| Katsui, Kuniaki\| Yoshio, Kotaro\| Ihara, Hiroki\| Katayama, Norihisa\| Soh, Junichi\| Kuroda, Masahiro\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Toyooka, Shinichi\| Kanazawa, Susumu\|
抄録	To clarify the relationship between dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) after surgery in cases of non-small cell lung cancer (NSCLC) treated with induction concurrent chemoradiotherapy (CCRT). Patients with NSCLC treated with induction CCRT (chemotherapy: cisplatin and docetaxel; radiotherapy: 2.0 Gy fractions once daily for a total of 46 Gy) before surgery were reviewed. We calculated the percentage of lung volume receiving at least 20 Gy (V20) and the mean lung dose (MLD) for the total lung volume and the lung remaining after resection. Factors affecting the incidence of RP at grade 2 or higher (≥ G2 RP) were analyzed. Eighteen of 49 patients (37%) experienced ≥G2 RP. The V20 and MLD for the lung remaining after resection (V20r and MLDr) were significant predictors according to the multivariate analysis (p=0.007 and 0.041, respectively). The incidence of ≥G2 RP was 8% in patients with V20r<10%, and 13% in patients with MLDr<5.6 Gy, respectively. The optimal approach to reduce the rate of postoperative RP in patients with induction CCRT for NSCLC is to keep the V20r below 10% and/or the MLDr below 5.6 Gy in the radiotherapy planning.
キーワード	radiation pneumonitis V20 mean lung dose induction chemoradiotherapy non-small cell lung cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-10
巻	72巻
号	5号
出版者	Okayama University Medical School
開始ページ	507
終了ページ	513
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30369608

Clinical Characteristics of Febrile Outpatients : Possible Involvement of Thyroid Dysfunction in Febrile Tachycardia

JaLCDOI	10.18926/AMO/56242
フルテキストURL	72_5_447.pdf
著者	Oka, Kosuke\| Hanayama, Yoshihisa\| Sato, Asuka\| Omura, Daisuke\| Yasuda, Miho\| Hasegawa, Ko\| Obika, Mikako\| Otsuka, Fumio\|
抄録	We retrospectively analyzed the cases of 148 febrile patients whose body temperature (BT) was ≥ 37.5°C at our hospital. We categorized them into seven groups; those with bacterial and viral infection, nonspecific inflammation, neoplasm, connective tissue disease (CTD), drug-induced disease, and unidentified causes. Our analysis revealed that the patient’s BT at the 1st visit (BT-1st visit) and highest BT during the febrile period (BT-max) differed significantly among all categories except neoplasm. The greatest difference between BT-1st visit and BT-max was highest in the CTD group (1.5°C). Positive correlations of heart rate and C-reactive protein (CRP) level with BT-max and a negative correlation between serum sodium level with BT-max were uncovered. The serum thyroid-stimulating hormone (TSH) level and the ratio of TSH/free thyroxine were negatively correlated with BT-max, especially in the viral infection group, suggesting the existence of occult thyrotoxicosis in accord with a febrile condition, possibly leading to febrile tachycardia. A febrile gap between BT-1st visit and BT-max (except in the neoplasm group) was shown, in which BT-max was correlated with thyroid function. Clinicians should recognize the fluctuation of BT when diagnosing febrile patients, and tachycardia in such febrile patients may be, at least in part, associated with subclinical thyroid dysfunction.
キーワード	body temperature C-reactive protein fever of unknown origin tachycardia thyroid dysfunction
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-10
巻	72巻
号	5号
出版者	Okayama University Medical School
開始ページ	447
終了ページ	456
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30369601

Epileptic High-frequency Oscillations in Scalp Electroencephalography

JaLCDOI	10.18926/AMO/56166
フルテキストURL	72_4_325.pdf
著者	Shibata, Takashi\| Kobayashi, Katsuhiro\|
抄録	Electroencephalography (EEG) examines the functional state of the brain. High-frequency oscillations (HFOs) in the ripple (80-200/250 Hz) and fast ripple (200/250-500/600 Hz) bands have recently been attracting attention, and their recording has been enabled by advancements in digital EEG techniques. The detection of HFOs was previously limited to intracranial EEG, but fast oscillations (FOs) in the gamma (40-80 Hz) and ripple bands can now be detected over the scalp. HFOs and FOs have been shown to be related to epileptogenicity in intracranial EEG and scalp EEG, respectively. A large number of FOs are found in the scalp EEGs of pediatric patients with various epileptic encephalopathies, particularly West syndrome. FOs are suggested to be a biomarker of the epileptogenic cortical region in epilepsy surgery. FOs are detectable even in patients with idiopathic focal epilepsies, including benign epilepsy with centrotemporal spikes and Panayiotopoulos syndrome, who are not generally candidates for operation. The detection of HFOs and FOs may provide clues to the pathophysiology of epilepsy and the relationship between HFOs and cognitive dysfunction.
キーワード	electroencephalogram high-frequency oscillations fast oscillations time-frequency analysis epilepsy
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	325
終了ページ	329
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140078

Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins

フルテキストURL	J_Cell_Biochem_118_1_43.pdf
著者	Eguchi, Takanori\| Calderwood, Stuart K.\| Takigawa, Masaharu\| Kubota, Satoshi\| Kozaki, Ken‐ichi\|
キーワード	CBXs CHROMOBOX PROTEINS HEAT SHOCK FACTOR 1 HEAT SHOCK PROTEINS HETEROCHROMATIN PROTEINS HP1 HSF1 HSPs MATRIX METALLOPROTEINASE MMP3 TRANSCRIPTION
発行日	2016-05-21
出版物タイトル	Journal of Cellular Biochemistry
巻	118巻
号	1号
出版者	Wiley
開始ページ	43
終了ページ	51
ISSN	07302312
NCID	AA1052210X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	27206651
DOI	10.1002/jcb.25607
Web of Science KeyUT	000387809300005
関連URL	isVersionOf https://doi.org/10.1002/jcb.25607

Determination of reference values for normal cranial morphology by using mid-sagittal vector analysis in Japanese children

フルテキストURL	K0005778_abstract_review.pdf K0005778_summary.pdf K0005778_fulltext.pdf
著者	妹尾貴矢\|
発行日	2018-06-30
資料タイプ	学位論文
学位授与番号	甲第5778号
学位授与年月日	2018-06-30
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Analysis of All 34 Exons of the SPINK5 Gene in Japanese Atopic Dermatitis Patients

JaLCDOI	10.18926/AMO/56073
フルテキストURL	72_3_275.pdf
著者	Morizane, Shin\| Ouchida, Mamoru\| Sunagawa, Ko\| Sugimoto, Saeko\| Kobashi, Mina\| Sugihara, Satoru\| Nomura, Hayato\| Tsuji, Kazuhide\| Sato, Atsushi\| Miura, Yoshihiro\| Hattori, Hiroaki\| Tada, Kotaro\| Huh, Wook-Kang\| Seno, Akemi\| Iwatsuki, Keiji\|
抄録	Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a large multidomain serine protease inhibitor that is expressed in epidermal keratinocytes. Nonsense mutations of the SPINK5 gene, which codes for LEKTI, cause Netherton syndrome, which is characterized by hair abnormality, ichthyosis, and atopy. A single nucleotide polymorphism (SNP) of SPINK5, p.K420E, is reported to be associated with the pathogenesis of atopic dermatitis (AD). We studied all 34 exons of the SPINK5 gene in Japanese 57 AD patients and 50 normal healthy controls. We detected nine nonsynonymous variants, including p.K420E; these variants had already been registered in the SNP database. Among them, p.R654H (n=1) was found as a heterozygous mutation in the AD patients, but not in the control. No new mutation was detected. We next compared the data of the AD patients with data from the Human Genetic Variation Database provided by Kyoto University; a significant difference was found in the frequency of the p.S368N genotype distribution. PolyPhen-2 and SIFT, two algorithms for predicting the functional effects of amino acid substitutions, showed significant scores for p.R654H. Therefore, R654H might be a risk factor for epidermal barrier dysfunction in some Japanese AD patients.
キーワード	atopic dermatitis SPINK5 LEKTI serine protease inhibitor epidermal barrier dysfunction
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-06
巻	72巻
号	3号
出版者	Okayama University Medical School
開始ページ	275
終了ページ	282
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29926005

Renal Function after Nephrectomy Influences the Risk of Cardiovascular Events

JaLCDOI	10.18926/AMO/56069
フルテキストURL	72_3_241.pdf
著者	Kambara, Taiki\| Tanimoto, Ryuta\| Araki, Motoo\| Saika, Takashi\| Hashimoto, Hideaki\| Oeda, Tadashi\| Tsushima, Tomoyasu\| Hayata, Shunji\| Nasu, Yasutomo\| Kobayashi, Yasuyuki\|
抄録	We retrospectively analyzed the factors related to postoperative cardiovascular (CV) events in patients undergoing partial nephrectomy (PN) or radical nephrectomy (RN) for clinical T1 renal cell carcinoma (RCC). We identified 570 patients who underwent PN or RN for T1 renal cell carcinoma between January 1998 and December 2009 at our institution and related hospitals. We determined the cumulative incidence rate of CV events and overall survival (OS) using Kaplan-Meier survival curves with a log-rank test, and we evaluated the risk for an increase in CV events and OS using Cox proportional hazard regression. Of the 570 patients, 171 underwent PN and 399 underwent RN. The type of surgery was not significantly related with CV events. The only factor that significantly increased the risk of CV events in both the univariate (HR 2.67, p=0.006) and multivariate analyses (HR 2.14, p=0.044) was a postoperative estimated glomerular filtration rate (eGFR) <45 ml/min/1.73 m2. Postoperative eGFR was also a significant risk factor for OS in the univariate analysis (HR 2.38, p=0.0104), but not in the multivariate model. Postoperative renal function was a significant independent predictor of the incidence of subsequent CV events.
キーワード	renal cell carcinoma nephrectomy partial nephrectomy renal function
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-06
巻	72巻
号	3号
出版者	Okayama University Medical School
開始ページ	241
終了ページ	247
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29926001

High Baseline Lipoprotein(a) Level as a Risk Factor for Coronary Artery Calcification Progression: Sub-analysis of a Prospective Multicenter Trial

JaLCDOI	10.18926/AMO/56067
フルテキストURL	72_3_223.pdf
著者	Ida, Jun\| Kotani, Kazuhiko\| Miyoshi, Toru\| Nakamura, Kazufumi\| Kohno, Kunihisa\| Asonuma, Hirohiko\| Sakuragi, Satoru\| Doi, Masayuki\| Miki, Takashi\| Koyama, Yasushi\| Ito, Hiroshi\|
抄録	Lipoprotein(a), or Lp(a), is a low-density lipoprotein-like particle largely independent of known risk factors for, and predictive of, cardiovascular disease (CVD). We investigated the association between baseline Lp(a) levels and the progression of coronary artery calcification (CAC) in patients with hypercholesterolemia undergoing statin therapy. This study was a sub-analysis of a multicenter prospective study that evaluated the annual progression of CAC under intensive and standard pitavastatin treatment with or without eicosapentaenoic acid in patients with an Agatston score of 1 to 999, and hypercholesterolemia treated with statins. We classified the patients into 3 groups according to CAC progression. A total of 147 patients (mean age, 67 years; men, 54%) were analyzed. The proportion of patients with Lp(a) > 30 mg/dL significantly increased as CAC progressed (non-progression; 5.4%, 0100; 23.6%). Logistic regression analysis showed that Lp(a) > 30 mg/dL was an independent predictor of the annual change in Agatston score > 100 (OR: 5.51; 95% CI: 1.28-23.68; p=0.02), even after adjusting for age, sex, hypertension, diabetes mellitus, current smoking, body mass index, and lipid-lowering medications. Baseline Lp(a) >30 mg/dL was a predictor of CAC progression in this population of patients with hypercholesterolemia undergoing statin therapy.
キーワード	lipoprotein(a) coronary artery calcification statins hypercholesterolemia
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-06
巻	72巻
号	3号
出版者	Okayama University Medical School
開始ページ	223
終了ページ	230
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29925999

Clinical and Functional Significance of Intracellular and Extracellular microRNA-25-3p in Osteosarcoma

JaLCDOI	10.18926/AMO/55857
フルテキストURL	72_2_165.pdf
著者	Yoshida, Aki\| Fujiwara, Tomohiro\| Uotani, Koji\| Morita, Takuya\| Kiyono, Masahiro\| Yokoo, Suguru\| Hasei, Joe\| Nakata, Eiji\| Kunisada, Toshiyuki\| Ozaki, Toshifumi\|
抄録	Although there is considerable evidence indicating that the dysregulation of microRNAs (miRNAs) in malignant tumors plays a role in tumor development, the overall function of miRNAs and their clinicopathological significance are not well understood. In this retrospective analysis of 45 biopsy specimens from osteosarcoma (OS) patients, we investigated the functional and clinical significance of miR-25-3p in OS, which we previously identified as a highly expressed miRNA in OS patients’ serum. We observed that miR-25-3p dysregulation in human OS tissues was negatively correlated with the clinical prognosis, whereas the expression level of its target gene, Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3), was positively correlated with the clinical prognosis. Endogenous miR-25-3p upregulation promoted tumor growth, invasion, and drug resistance, which was consistent with DKK3 silencing in OS cells. In addition, secretory miR-25-3p was embedded in tumor-derived exosomes, where it promoted capillary formation and the invasion of vascular endothelial cells. Overall, our results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in OS, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease.
キーワード	microRNA circulating microRNA osteosarcoma prognosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-04
巻	72巻
号	2号
出版者	Okayama University Medical School
開始ページ	165
終了ページ	174
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29674765

Slow Fetal Heart Rate before Miscarriage in the Early First Trimester Predicts Fetal Aneuploidy in Women with Recurrent Pregnancy Loss

JaLCDOI	10.18926/AMO/55664
フルテキストURL	72_1_61.pdf
著者	Sakamoto, Ai\| Kamada, Yasuhiko\| Kubo, Kotaro\| Hasegawa, Toru\| Kotani, Sayoko\| Nakatsuka, Mikiya\| Hiramatsu, Yuji\|
抄録	Establishing whether miscarriages result from fetal aneuploidy or other factors is important for treating recurrent pregnancy loss. We examined the relationship between fetal heart rate (FHR) before miscarriage in the early first trimester and fetal karyotype, analyzing 223 pregnant women with recurrent pregnancy loss. Among the pregnancies, 110 resulted in live births regarded as normal karyotype (the Norm-group). The other 113 pregnancies ended in miscarriage, and we categorized them into groups based on fetal karyotype, determined by chorionic villus sampling: the Misc-NK (normal karyotype) group, n=35 euploid cases; the Misc-CA1 (chromosomal abnormality) group, n=18 cases of aneuploidy with trisomies 13/18/21, Turner’s syndrome, or Klinefelter’s syndrome; and the Misc-CA2 subgroup, n=60 cases of other aneuploidies excluding those in the Misc-CA1 group. We compared the groups’ regression line slopes and intercepts for FHR by an analysis of covariance. The FHRs of the Norm, Misc-NK and Misc-CA1 groups increased from 36 to 49 days after fertilization, but did not significantly differ across these groups. The Misc-CA2 group’s FHR did not increase and significantly differed from the other three groups (p<0.01). These results suggest that the absence of an increase in FHR in early pregnancy may indicate the presence of chromosomal abnormalities causing miscarriage.
キーワード	aneuploidy chorionic villi fetal heart rate recurrent pregnancy loss
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-02
巻	72巻
号	1号
出版者	Okayama University Medical School
開始ページ	61
終了ページ	66
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29463940

Transcatheter Arterial Chemoembolization to Reduce Size of Hepatocellular Carcinoma before Radiofrequency Ablation

JaLCDOI	10.18926/AMO/55662
フルテキストURL	72_1_47.pdf
著者	Ako, Soichiro\| Nakamura, Shinichiro\| Nouso, Kazuhiro\| Dohi, Chihiro\| Wada, Nozomu\| Morimoto, Yuki\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Kuwaki, Kenji\| Onishi, Hideki\| Ikeda, Fusao\| Shiraha, Hidenori\| Takaki, Akinobu\| Okada, Hiroyuki\|
抄録	Transcatheter arterial chemoembolization (TACE) is often performed before radiofrequency ablation (RFA) for the treatment of early-stage hepatocellular carcinoma (HCC). TACE prior to RFA can expand the ablated area and reduce the tumor size, facilitating complete ablation. However, the factors correlated with size reduction remain uncertain. The aim of this study was to identify the factors associated with size reduction by TACE and develop a formula to predict the reduction rate. A total of 100 HCC patients treated with TACE followed by RFA at least 20 days later were enrolled. The tumor size was measured at the time of TACE and RFA, and correlations between the reduction rate and 13 clinical factors were examined. A formula to predict the reduction rate was built using the factors obtained by the analysis. Reduction in the tumor size was observed in 69 nodules, and the median reduction rate was 16.2%. A multivariate regression analysis revealed that a large tumor size (p< 0.01) and a long interval between the therapies (p= 0.01) were factors for a high tumor reduction rate, with tumor size more strongly related to the degree of reduction. A size reduction of more than 10% can be expected by waiting 20 days after TACE when the size of the tumor at TACE is over 25 mm in diameter. The tumor size
キーワード	hepatocellular carcinoma transcatheter arterial chemoembolization radiofrequency ablation interval size reduction
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-02
巻	72巻
号	1号
出版者	Okayama University Medical School
開始ページ	47
終了ページ	52
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29463938

Complete right bundle branch block and QRS-T discordance can be the initial clue to detect S-ICD ineligibility

フルテキストURL	J_Cardiology_70_1_23.pdf Fig.pdf
著者	Tachibana, Motomi\| Nishii, Nobuhiro\| Morimoto, Yoshimasa\| Kawada, Satoshi\| Miyoshi, Akihito\| Sugiyama, Hiroyasu\| Nakagawa, Koji\| Watanabe, Atsuyuki\| Nakamura, Kazufumi\| Morita, Hiroshi\| Ito, Hiroshi\|
キーワード	Implantable cardioverter-defibrillator Sudden cardiac death Ventricular arrhythmia
備考	This is an Accepted Manuscript of an article published by Elsevier\|
発行日	2017-07
出版物タイトル	Journal of Cardiology
巻	70巻
号	1号
出版者	Japanese College of Cardiology
開始ページ	23
終了ページ	28
ISSN	0914-5087
NCID	AN10070473
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	28034575
DOI	10.1016/j.jjcc.2016.11.014
Web of Science KeyUT	000408601100004
関連URL	isVersionOf https://doi.org/10.1016/j.jjcc.2016.11.014

Metachronous Neoplasia and Local Recurrence after Colorectal Endoscopic Submucosal Dissection

JaLCDOI	10.18926/AMO/55584
フルテキストURL	71_6_475.pdf
著者	Takei, Daisuke\| Harada, Keita\| Takashima, Shiho\| Inokuchi, Toshihiro\| Nakarai, Asuka\| Sugihara, Yusaku\| Takahara, Masanobu\| Hiraoka, Sakiko\| Okada, Hiroyuki\|
抄録	Several reports discussed colonoscopic surveillance after polypectomy and endoscopic mucosal resection (EMR) for colorectal polyps, but only a few reports focused on prognostic analyses, and none involved metachronous neoplasia after colorectal endoscopic submucosal dissection (ESD). We conducted the present study to assess the risk of adenoma recurrence requiring endoscopic treatment, and to establish appropriate post-ESD colonoscopic surveillance. We enrolled 116 patients who had undergone colorectal ESD at Okayama University Hospital between February 2008 and July 2014 and had been followed-up >12 months. We retrospectively analyzed clinicopathological features of 101 lesions from 101 patients. Metachronous adenomas were detected in 21 cases (20.8%). We divided the patients into 2 groups according to the occurrence of metachronous adenomas. Our comparison of clinicopathological characteristics between these groups showed that in the metachronous adenomas group the number of synchronous adenomas at index colonoscopy was high and the rate of laterally spreading tumor-nongranular (LST-NG) was higher. A multivariate analysis indicated that the number of synchronous adenomas was significantly associated with metachronous adenomas (HR: 2.54, 95%CI: 1.04-6.52, p<0.05). The colonoscopic surveillance planning after colorectal ESD should be more meticulous for patients with more synchronous adenomas.
キーワード	endoscopic submucosal dissection laterally spreading tumor metachronous recurrence local recurrence post-ESD colonoscopic surveillance
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2017-12
巻	71巻
号	6号
出版者	Okayama University Medical School
開始ページ	475
終了ページ	483
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	29276220