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ID 49256
JaLCDOI
フルテキストURL
67_1_45.pdf 471 KB
著者
Hashizume, Hiroaki Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Sato, Ken Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Yamazaki, Yuichi Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Horiguchi, Norio Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Kakizaki, Satoru Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Mori, Masatomo Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
抄録
In patients with nonalcoholic steatohepatitis (NASH), the prevalence of cirrhosis is higher among women than men, and hepatocellular carcinoma (HCC) develops mainly in the cirrhotic stage among women. However, the long-term outcomes in female patients with NASH have not been fully elucidated, and age, gender and BMI were not simultaneously adjusted in previous studies on the prognosis of NASH. To elucidate the outcomes in female patients with NASH, we prospectively compared NASH patients with advanced fibrosis (advanced NASH) with hepatitis C virus-related advanced fibrosis (advanced CHC) patients and NASH patients with mild fibrosis (mild NASH) using study cohorts that were adjusted for body mass index (BMI) in addition to age. The median follow-up period was 92.5 months. Liver-related complication-free survival was significantly reduced in the advanced NASH group compared to the mild NASH group. No liver-related complications developed in the mild NASH group. The overall survival, liver-related complication- and cardiovascular/cerebrovascular disease-free survival were not significantly different between the advanced NASH and CHC groups. Female patients with NASH and advanced fibrosis may have a less favorable prognosis for liver-related complications than the matched cohorts with NASH and mild fibrosis, but may have a similar prognosis to the matched cohorts with CHC.
キーワード
nonalcoholic steatohepatitis
chronic hepatitis C
prognosis
female
Amo Type
Original Article
出版物タイトル
Acta Medica Okayama
発行日
2013-02
67巻
1号
出版者
Okayama University Medical School
開始ページ
45
終了ページ
53
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
英語
著作権者
CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT