検索結果 287 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hiraki, Takahiro| Okai, Koichi| Bartokos, Michael| Beeks, Kjeld| Fujimoto, Hiroyuki| Fukunaga, Yuta| Haba, Hiromitsu| Kasamatsu, Yoshitaka| Kitao, Shinji| Leitner, Adrian| Masuda, Takahiko| Guan, Ming| Nagasawa, Nobumoto| Ogake, Ryoichiro| Pimon, Martin| Pressler, Martin| Sasao, Noboru| Schaden, Fabian| Schumm, Thorsten| Seto, Makoto| Shigekawa, Yudai| Shimizu, Kotaro| Sikorsky, Tomas| Tamasaku, Kenji| Takatori, Sayuri| Watanabe, Tsukasa| Yamaguchi, Atsushi| Yoda, Yoshitaka| Yoshimi, Akihiro| Yoshimura, Koji| |
| 備考 | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-49631-0| |
| 発行日 | 2024-07-16 |
| 出版物タイトル | Nature Communications |
| 巻 | 15巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 5536 |
| ISSN | 2041-1723 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 39013899 |
| DOI | 10.1038/s41467-024-49631-0 |
| Web of Science KeyUT | 001270192000037 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41467-024-49631-0 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Oguma, Yukiko| Yamamoto, Masanori| Sunatsuki, Yukinari| Ota, Hiromi| Yamaji, Minoru| Okamoto, Hideki| |
| キーワード | Cyclophane Azacyclophane Naphthalenophane Photocycloaddition [4 + 4] cycloaddition |
| 備考 | The version of record of this article, first published in Photochemical & Photobiological Sciences, is available online at Publisher’s website: http://dx.doi.org/10.1007/s43630-024-00610-w| |
| 発行日 | 2024-07-10 |
| 出版物タイトル | Photochemical & Photobiological Sciences |
| 巻 | 23巻 |
| 号 | 8号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 1509 |
| 終了ページ | 1519 |
| ISSN | 1474-905X |
| NCID | AA11791060 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38981991 |
| DOI | 10.1007/s43630-024-00610-w |
| Web of Science KeyUT | 001268956300001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s43630-024-00610-w |
| フルテキストURL | fulltext20240716-03.pdf |
|---|---|
| 著者 | Nakanishi, Kotaro| Kojima, Keiichi| Sowa, Yoshiyuki| Sudo, Yuki| |
| 備考 | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Physical Chemistry B, copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcb.4c03027.| This fulltext file will be available in Aug. 2025.| |
| 発行日 | 2024-07-01 |
| 出版物タイトル | The Journal of Physical Chemistry B |
| 巻 | 128巻 |
| 号 | 27号 |
| 出版者 | American Chemical Society (ACS) |
| 開始ページ | 6509 |
| 終了ページ | 6517 |
| ISSN | 1520-6106 |
| NCID | AA11114073 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 American Chemical Society |
| 論文のバージョン | author |
| PubMed ID | 38949422 |
| DOI | 10.1021/acs.jpcb.4c03027 |
| Web of Science KeyUT | 001261316100001 |
| 関連URL | isVersionOf https://doi.org/10.1021/acs.jpcb.4c03027 |
| JaLCDOI | 10.18926/AMO/67201 |
|---|---|
| フルテキストURL | 78_3_259.pdf |
| 著者 | Vural, Gonul| Demir, Esra| Gumusyayla, Sadiye| Eren, Funda| Barakli, Serdar| Neselioglu, Salim| Erel, Ozcan| |
| 抄録 | The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured. We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients. |
| キーワード | multiple sclerosis dysfunctional HDL thiol–disulfide homeostasis cognitive decline |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 259 |
| 終了ページ | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902214 |
| Web of Science KeyUT | 001267351000007 |
| フルテキストURL | fulltext20240527-01.pdf |
|---|---|
| 著者 | Nose, Keito| Yamaji, Minoru| Tani, Fumito| Goto, Kenta| Okamoto, Hideki| |
| キーワード | Phenacene Imide Fluorescence Solvatofluorochromism Intramolecular charge transfer |
| 備考 | © 2024 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Mar. 2026.| |
| 発行日 | 2024-07-01 |
| 出版物タイトル | Journal of Photochemistry and Photobiology A: Chemistry |
| 巻 | 452巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 115613 |
| ISSN | 1010-6030 |
| NCID | AA10684407 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Elsevier B.V. |
| 論文のバージョン | author |
| DOI | 10.1016/j.jphotochem.2024.115613 |
| Web of Science KeyUT | 001222715400001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jphotochem.2024.115613 |
| フルテキストURL | fulltext20240501-01.pdf |
|---|---|
| 著者 | Zou, Yajuan| Shikano, Yutaka| Nishina, Yuta| Komatsu, Naoki| Kage-Nakadai, Eriko| Fujiwara, Masazumi| |
| キーワード | iron oxide nanoparticles polyglycerol functionalization C. elegans accumulation distribution toxicity |
| 発行日 | 2024-06 |
| 出版物タイトル | Chemosphere |
| 巻 | 358巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 142060 |
| ISSN | 0045-6535 |
| NCID | AA00603442 |
| 資料タイプ | プレプリント |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Elsevier Ltd. |
| 論文のバージョン | author |
| PubMed ID | 38648981 |
| DOI | 10.1016/j.chemosphere.2024.142060 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.chemosphere.2024.142060 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| フルテキストURL | 78_2_151.pdf |
| 著者 | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| 抄録 | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| キーワード | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 151 |
| 終了ページ | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
| JaLCDOI | 10.18926/AMO/66152 |
|---|---|
| フルテキストURL | 77_6_607.pdf |
| 著者 | Tani, Yasunari| Kashima, Saori| Mitsuhashi, Toshiharu| Suzuki, Etsuji| Takao, Soshi| Yorifuji, Takashi| |
| 抄録 | Many studies have shown an association between long-term exposure to particulate matter having an aerodynamic diameter of 2.5 μm or less (PM2.5) and diabetes mellitus (DM), but few studies have focused on Asian subjects. We thus examined the association between long-term exposure to PM2.5 and DM prevalence in Okayama City, Japan. We included 76,591 participants who had received basic health checkups in 2006 and 2007. We assigned the census-level modeled PM2.5 data from 2006 and 2007 to each participant and defined DM using treatment status and the blood testing. PM2.5 was associated with DM prevalence, and the prevalence ratio (95% confidence interval) was 1.10 (1.00-1.20) following each interquartile range increase (2.1 μg/m3) in PM2.5. This finding is consistent with previous results and suggests that long-term exposure to PM2.5 is associated with an increased prevalence of DM in Okayama City, Japan, where the PM2.5 level is lower than in other cities in Asian countries. |
| キーワード | air pollution diabetes mellitus epidemiology glycosylated hemoglobin particulate matter |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 607 |
| 終了ページ | 612 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145934 |
| Web of Science KeyUT | 001164631200005 |
| フルテキストURL | fulltext20231101-01.pdf |
|---|---|
| 著者 | Ren, Jianchao| Danchana, Kaewta| Sasaki, Keiko| Kaneta, Takashi| |
| キーワード | Laccase Mushroom Fluorometry 2,2'-Azinobis(3-ethylbenzthiazolin-6-sulfonic acid) N-Benzoyl leucomethylene blue |
| 備考 | © 2023 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Aug. 2024.| |
| 発行日 | 2023-10 |
| 出版物タイトル | Journal of Food Composition and Analysis |
| 巻 | 123巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 105627 |
| ISSN | 0889-1575 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Elsevier Inc. |
| 論文のバージョン | author |
| DOI | 10.1016/j.jfca.2023.105627 |
| Web of Science KeyUT | 001068657200001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jfca.2023.105627 |
| JaLCDOI | 10.18926/AMO/65974 |
|---|---|
| フルテキストURL | 77_5_517.pdf |
| 著者 | Horiguchi, Shigeru| Matsumoto, Kazuyuki| Morimoto, Kosaku| Matsumi, Akihiro| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Tsutsumi, Koichiro| Kato, Hironari| |
| 抄録 | We investigated the effect of modified FOLFIRINOX (mFFX) in unresectable pancreatic cancer by retrospectively analyzing the cases of 43 patients who underwent BRCA testing (germline, n=11; somatic, n=26; both germline and somatic, n=6). The association between BRCA mutations and therapeutic effect was clarified. Six patients tested positive for germline pathogenic variants. Familial pancreatic cancer (33% vs. 3%, p=0.006) and peritoneal disseminated lesions (66% vs. 8%, p<0.001) were significantly more common in patients with germline pathogenic variants. The partial response (PR) rate was 100% in the germline BRCA-positive patients, and 27% in the germline BRCA-negative patients (p<0.001). The median progression-free survival (PFS) was not reached for any germline BRCA-positive patients but was 9.0 months for the germline BRCA-negative patients (p=0.042). Patients with stage IV BRCA-associated pancreatic cancer had better overall survival than those with non-BRCA-associated pancreatic cancer, although the difference was nonsignificant (not reached vs. 655 days, p=0.061). Our results demonstrate that a PR and prolonged PFS can be expected in germline BRCA-positive patients after treatment with mFFX. Our findings also suggest that germline BRCA pathogenic variants may be useful as biomarkers for the therapeutic effect of mFFX in patients with pancreatic cancer. |
| キーワード | BRCA FOLFIRINOX pancreatic cancer progression-free survival pathogenic variant |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-10 |
| 巻 | 77巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 517 |
| 終了ページ | 525 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37899263 |
| Web of Science KeyUT | 001108661600009 |
| フルテキストURL | fulltext20231011-03.pdf |
|---|---|
| 著者 | Kurihara, Marie| Thiel, Vera| Takahashi, Hirona| Kojima, Keiichi| Ward, David M.| Bryant, Donald A.| Sakai, Makoto| Yoshizawa, Susumu| Sudo, Yuki| |
| キーワード | rhodopsin ion transport retinal isomerization optogenetics |
| 発行日 | 2023-02-01 |
| 出版物タイトル | Chemical and Pharmaceutical Bulletin |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Pharmaceutical Society of Japan |
| 開始ページ | 154 |
| 終了ページ | 164 |
| ISSN | 0009-2363 |
| NCID | AA00602100 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 The Pharmaceutical Society of Japan |
| 論文のバージョン | publisher |
| PubMed ID | 36724978 |
| DOI | 10.1248/cpb.c22-00774 |
| Web of Science KeyUT | 000964953300013 |
| 関連URL | isVersionOf https://doi.org/10.1248/cpb.c22-00774 |
| フルテキストURL | fulltext20231004-01.pdf |
|---|---|
| 著者 | Shimooka, So| Kawanaka, Miku| Gofuku, Akio| |
| キーワード | Soft rotary actuator Extension soft actuator Flexible shaft Pneumatic drive |
| 備考 | © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Oct. 2025.| |
| 発行日 | 2023-10-16 |
| 出版物タイトル | Sensors and Actuators A: Physical |
| 巻 | 361巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 114603 |
| ISSN | 0924-4247 |
| NCID | AA10781039 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Elsevier B.V. |
| 論文のバージョン | author |
| DOI | 10.1016/j.sna.2023.114603 |
| Web of Science KeyUT | 001067606600001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.sna.2023.114603 |
| フルテキストURL | fulltext20230828-02.pdf |
|---|---|
| 著者 | Ono, Ryota| Saeki, Nozomu| Kojima, Keiichi| Moriya, Hisao| Sudo, Yuki| |
| キーワード | UVA Saccharomyces cerevisiae Iodide Growth inhibition Suppressive molecule |
| 備考 | © 2023 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Oct. 2024.| |
| 発行日 | 2023-10-15 |
| 出版物タイトル | Biochemical and Biophysical Research Communications |
| 巻 | 677巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 1 |
| 終了ページ | 5 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Elsevier Inc. |
| 論文のバージョン | author |
| PubMed ID | 37523893 |
| DOI | 10.1016/j.bbrc.2023.07.048 |
| Web of Science KeyUT | 001047346900001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.bbrc.2023.07.048 |
| JaLCDOI | 10.18926/AMO/65746 |
|---|---|
| フルテキストURL | 77_4_371.pdf |
| 著者 | Iwamoto, Yosuke| Kaya, Mitsunori| Kijima, Hiroaki| Fujii, Masashi| Nagahata, Itsuki| Miyakoshi, Naohisa| |
| 抄録 | In recent publications on greater trochanteric pain syndrome (GTPS), the pathology receiving the most attention has been gluteus medius muscle tendinous injury, and surgical techniques such as gluteus medius tendon repair and their outcomes for GTPS have been reported. In our department-related facilities, arthroscopic surgeries are routinely performed for the patients with recalcitrant GTPS. A total of 51 patients were diagnosed with GTPS. Surgical treatment was carried out 22 patients (24 joints; 4 males and 18 females; mean age at surgery of 52.0 years). Arthroscopic findings confirmed bursitis in all 24 joints. In all cases, debridement of the greater trochanter bursa provided rapid relief of greater trochanter pain. The Numerical Rating Scale showed significant improvement, from the preoperative mean of 7.8 (range, 6-10) to the postoperative day 7 mean of 1.6 (range, 0-3). The modified Harris Hip Score was significantly improved from the preoperative mean of 65.5 (range, 52.5-78.3) to the final follow-up (average 2.9 months) mean of 96.0 (range, 85.2-100). Fascial damage of the gluteus medius muscle was observed in 21 joints while only 2 patients had a gluteus medius tendinous injury. Greater trochanteric bursitis and fascia or muscle-fiber injury of the gluteus medius muscle are the most common pathologies in patients with lateral hip pain. |
| キーワード | greater trochanteric pain syndrome endoscopic findings bursitis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-08 |
| 巻 | 77巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 371 |
| 終了ページ | 375 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37635137 |
| Web of Science KeyUT | 001163659800005 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kojima, Keiichi| Kawanishi, Shiho| Nishimura, Yosuke| Hasegawa, Masumi| Nakao, Shin| Nagata, Yuya| Yoshizawa, Susumu| Sudo, Yuki| |
| 備考 | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-34125-8| |
| 発行日 | 2023-04-28 |
| 出版物タイトル | Scientific Reports |
| 巻 | 13巻 |
| 号 | 1号 |
| 出版者 | nature portfolio |
| 開始ページ | 6974 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2023 |
| 論文のバージョン | publisher |
| PubMed ID | 37117398 |
| DOI | 10.1038/s41598-023-34125-8 |
| Web of Science KeyUT | 000985908500047 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-023-34125-8 |
| フルテキストURL | fulltext20230413-01.pdf |
|---|---|
| 著者 | Kumano, Shota| Takaki, Tomoyasu| Uchida, Tetsuya| |
| 発行日 | 2023-2-17 |
| 出版物タイトル | Polymer Journal |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 0032-3896 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2023. |
| 論文のバージョン | publisher |
| DOI | 10.1038/s41428-023-00765-w |
| Web of Science KeyUT | 000934721800001 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41428-023-00765-w |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tanaka, Hiroyoshi Y.| Nakazawa, Takuya| Enomoto, Atsushi| Masamune, Atsushi| Kano, Mitsunobu R.| |
| キーワード | pancreatic cancer tumor microenvironment nanomedicine fibrosis extracellular matrix fibroblast |
| 発行日 | 2023-01-24 |
| 出版物タイトル | Cancers |
| 巻 | 15巻 |
| 号 | 3号 |
| 出版者 | MDPI |
| 開始ページ | 724 |
| ISSN | 2072-6694 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36765684 |
| DOI | 10.3390/cancers15030724 |
| Web of Science KeyUT | 000929314700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/cancers15030724 |
| JaLCDOI | 10.18926/AMO/64355 |
|---|---|
| フルテキストURL | 77_1_1.pdf |
| 著者 | Nahar, Lutfun| Hagiya, Hideharu| Nada, Takahiro| Iio, Koji| Gotoh, Kazuyoshi| Matsushita, Osamu| Otsuka, Fumio| |
| 抄録 | Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA. |
| キーワード | antimicrobial resistance clindamycin erm D-zone test inducible MLSB |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 9 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849140 |
| Web of Science KeyUT | 000953663800001 |
| JaLCDOI | 10.18926/AMO/64124 |
|---|---|
| フルテキストURL | 76_6_731.pdf |
| 著者 | Kamamura, Maho| Higaki, Fumiyo| Sasada, Susumu| Matsushita, Toshi| Yasuhara, Takao| Date, Isao| Hiraki, Takao| |
| 抄録 | We report a rare case of idiopathic spinal cord herniation (ISCH) with a history of cerebrospinal fluid (CSF) leakage. ISCH is a protrusion of the spinal cord through a dural defect. Thin constructive interference in steady-state (CISS) images clearly demonstrated the herniated cord in the present case. The myelopathy worsened and the patient underwent surgery for reduction of herniated spinal cord; the dural defect was filled by placing collagen matrix graft (DuraGen®) between the inner and outer dural layers. The patient’s symptoms have improved without relapse for 8 months since surgery. This method may be a good surgical option for cases of spinal cord herniation. |
| キーワード | cerebrospinal fluid leakage constructive interference in steady state collagen matrix graft magnetic resonance image spinal cord herniation |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 731 |
| 終了ページ | 736 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549776 |
| Web of Science KeyUT | 000905195100014 |
| JaLCDOI | 10.18926/AMO/64117 |
|---|---|
| フルテキストURL | 76_6_673.pdf |
| 著者 | Okazawa-Sakai, Mika| Yamamoto, Yasuko| Futagawa, Mashu| Okamura, Miki| Miyawaki, Satoko| Nishina, Tomohiro| Takehara, Kazuhiro| Kozuki, Toshiyuki| Tomida, Shuta| Hyodo, Ichinosuke| Ohsumi, Shozo| Hirasawa, Akira| |
| 抄録 | Patients found to have presumed germline pathogenic variants (PGPVs) during comprehensive genomic profiling (CGP) require genetic counseling (GC) referrals. We retrospectively investigated the outcomes of patients with PGPVs. Among 159 patients who underwent CGP, we recommended GC for the 16 patients with PGPVs (3 with [FG group] and 13 without [G Group] a family/personal history of hereditary cancer) as well as for the 8 patients with no PGPVs, but a history (F group); 2 (67%), 5 (38%), and 3 (38%) patients received GC in the FG, G, and F groups, respectively. Germline testing results were positive in 1 and 2 patients of the FG and G groups, respectively. Among the patients recommended for GC, 58% did not receive GC due to lack of interest, poor performance status, or death. CGP contributes to the identification of germline variants in patients without a history of hereditary cancer. However, the proportion of patients who undergo GC should be improved. |
| キーワード | comprehensive genomic profiling hereditary cancer germline findings presumed germline pathogenic variant(s) genetic counseling |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 673 |
| 終了ページ | 678 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549769 |
| Web of Science KeyUT | 000905195100007 |