検索結果 - 岡山大学学術成果リポジトリ

Complete genome sequence of Habenaria mosaic virus, a new potyvirus infecting a terrestrial orchid (Habenaria radiata) in Japan

フルテキストURL	ArchVirol_159_1_163.pdf
著者	Kondo, Hideki\| Maeda, Takanori\| I Wayan Gara\| Chiba, Sotaro\| Maruyama, Kazuyuki\| Tamada, Tetsuo\| Suzuki, Nobuhiro\|
発行日	2013-07-16
出版物タイトル	Archives of Virology
巻	159巻
号	1号
出版者	Springer
開始ページ	163
終了ページ	166
ISSN	0304-8608
NCID	AA00548901
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	23857506
DOI	10.1007/s00705-013-1784-6
Web of Science KeyUT	000330584800017
関連URL	isVersionOf https://doi.org/10.1007/s00705-013-1784-6

Cymbidium chlorotic mosaic virus, a new sobemovirus isolated from a spring orchid (Cymbidium goeringii) in Japan.

フルテキストURL	Arch_Virol_160_8_2099.pdf
著者	Kondo, Hideki\| Takemoto, Shogo\| Maruyama, Kazuyuki\| Chiba, Sotaro\| Ida Bagus Andika\| Suzuki, Nobuhiro\|
発行日	2015-05-31
出版物タイトル	Archives of Virology
巻	160巻
号	8号
出版者	Springer
開始ページ	2099
終了ページ	104
ISSN	0304-8608
NCID	AA00548901
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	26025156
DOI	10.1007/s00705-015-2460-9
Web of Science KeyUT	000359434000026
関連URL	isVersionOf https://doi.org/10.1007/s00705-015-2460-9

Characterization of burdock mottle virus, a novel member of the genus Benyvirus, and the identification of benyvirus-related sequences in the plant and insect genomes.

フルテキストURL	VirusRes_177_1_75.pdf Table 1-revised.pdf FigS-revised.pdf Figs_revised.pdf Table S.pdf
著者	Kondo, Hideki\| Hirano, Shuichi\| Chiba, Sotaro\| Andika, Ida Bagus\| Hirai, Makoto\| Maeda, Takanori\| Tamada, Tetsuo\|
キーワード	AlkB Benyvirus Burdock mottle virus Endogenous viral element Paleovirology Transcriptome shotgun assembly
発行日	2013-10
出版物タイトル	Virus Research
巻	177巻
号	1号
出版者	Elsevier Science
開始ページ	75
終了ページ	86
ISSN	01681702
NCID	AA10642076
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	23911632
DOI	10.1016/j.virusres.2013.07.015
Web of Science KeyUT	000324974100009
関連URL	isVersionOf https://doi.org/10.1016/j.virusres.2013.07.015

Two novel fungal negative-strand RNA viruses related to mymonaviruses and phenuiviruses in the shiitake mushroom (Lentinula edodes)

フルテキストURL	Virology_533_125.pdf
著者	Lin, Yu-Hsin\| Fujita, Miki\| Chiba, Sotaro\| Hyodo, Kiwamu\| Andika, Ida Bagus\| Suzuki, Nobuhiro\| Kondo, Hideki\|
キーワード	Ambisense Bipartite genome Endogenous virus element Evolution High-throughput sequencing Lentinula edodes Mymonaviridae Negative-strand RNA virus Phenuiviridae Shitake mushroom
備考	This fulltext will be available in May 2020\|
発行日	2019-07-31
出版物タイトル	Virology
巻	533巻
出版者	Academic Press
開始ページ	125
終了ページ	136
ISSN	00426822
NCID	AA00884454
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	31153047
DOI	10.1016/j.virol.2019.05.008
Web of Science KeyUT	000474941300015
関連URL	isVersionOf https://doi.org/10.1016/j.virol.2019.05.008

Combined effect of anti-high-mobility group box-1 monoclonal antibody and peramivir against influenza A virus-induced pneumonia in mice

フルテキストURL	K0005907_abstract_review.pdf K0005907_summary.pdf K0005907_fulltext.pdf
著者	畑山一貴\|
発行日	2019-03-25
資料タイプ	学位論文
学位授与番号	甲第5907号
学位授与年月日	2019-03-25
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy

JaLCDOI	10.18926/AMO/56178
フルテキストURL	72_4_401.pdf
著者	Wada, Nozomu\| Ikeda, Fusao\| Mori, Chizuru\| Takaguchi, Koichi\| Fujioka, Shin-ichi\| Kobashi, Haruhiko\| Morimoto, Yoichi\| Kariyama, Kazuya\| Sakaguchi, Kosaku\| Hashimoto, Noriaki\| Moriya, Akio\| Kawaguchi, Mitsuhiko\| Miyatake, Hirokazu\| Hagihara, Hiroaki\| Kubota, Junichi\| Takayama, Hiroki\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Takaki, Akinobu\| Iwasaki, Yoshiaki\| Okada, Hiroyuki\|
抄録	Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolled 951 HCV serogroup 1-positive patients who received this combination therapy at our hospital or affiliated hospitals. The presence of RAVs in non-structural (NS) regions 3 and 5A was analyzed by direct sequencing. HCV genotypes were determined by PCR with genotype-specific primers targeting HCV core and NS5B regions. SVR was achieved in 91.1% of patients. Female sex, age > 70 years, and RAVs were significantly associated with non-SVR (p<0.01 for all). Propensity score-matching results among the patients without RAVs regarding sex, age, and fibrosis revealed that mixed HCV infection determined by HCV NS5B genotyping showed significantly lower SVR rates than 1B-mono infection (p=0.02). Female sex and RAVs were significant factors associated with treatment failure of this combination therapy for patients with HCV serogroup 1 infection. Mixed HCV infection other than 1B-mono infection would be useful for predicting treatment failure.
キーワード	mixed genotype daclatasvir asunaprevir HCV serogrouping 1 infection
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	401
終了ページ	406
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140089

Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum).

フルテキストURL	viruses-09-00371.pdf
著者	Ogawa, Hirohito\| Kajihara, Masahiro\| Nao, Naganori\| Shigeno, Asako\| Fujikura, Daisuke\| Hang’ombe, Bernard M.\| Mweene, Aaron S.\| Mutemwa, Alisheke\| Squarre, David\| Yamada, Masao\| Higashi, Hideaki\| Sawa, Hirofumi\| Takada, Ayato\|
キーワード	Eidolon helvum Zambia adenovirus bat
発行日	2017-12-04
出版物タイトル	Viruses
巻	9巻
号	12号
出版者	MDPI
開始ページ	371
ISSN	1999-4915
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	publisher
PubMed ID	29207524
DOI	10.3390/v9120371
関連URL	isVersionOf https://doi.org/10.3390/v9120371

Development of hepatitis C virus production reporter-assay systems using two different hepatoma cell lines

フルテキストURL	K0005289_other1.pdf
著者	Takeda, Midori\| Ikeda, Masanori\| Ariumi, Yasuo\| Wakita, Takaji\| Kato, Nobuyuki\|
備考	学位審査副論文\|
発行日	2012-07
出版物タイトル	Journal of General Virology
巻	93巻
号	7号
出版者	Cambridge Univ. Press for the Society for General Microbiology
開始ページ	1422
終了ページ	1431
ISSN	0022-1317
NCID	AA00698722
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	22456614
DOI	10.1099/vir.0.040725-0
Web of Science KeyUT	000306348900003
関連URL	https://doi.org/10.1099/vir.0.040725-0 http://ousar.lib.okayama-u.ac.jp/54272

Identification of host genes showing differential expression profiles with cell-based long-term replication of hepatitis C virus RNA

フルテキストURL	K0005288_other.pdf
著者	Sejima, Hiroe\| Mori, Kyoko\| Ariumi, Yasuo\| Ikeda, Masanori\| Kato, Nobuyuki\|
キーワード	HCV HCV RNA replication system Li23 cells Long-term RNA replication Upregulated host genes Downregulated host genes
備考	学位審査副論文\|
発行日	2012-07
出版物タイトル	Virus Research
巻	167巻
号	1号
出版者	Elsevier Science
開始ページ	74
終了ページ	85
ISSN	0168-1702
NCID	AA10642076
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	22579597
DOI	10.1016/j.virusres.2012.04.008
Web of Science KeyUT	000305496700010
関連URL	https://doi.org/10.1016/j.virusres.2012.04.008 http://ousar.lib.okayama-u.ac.jp/54271

Monitoring of Human Herpesviruses-6 and -7 DNA in Saliva Samples During the Acute and Convalescent Phases of Exanthem Subitum

フルテキストURL	K0005477_abstract_review.pdf K0005477_summary.pdf K0005477_fulltext.pdf
著者	宮崎裕樹\|
発行日	2017-03-24
資料タイプ	学位論文
学位授与番号	甲第5477号
学位授与年月日	2017-03-24
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語

平成27年度岡山医学会賞がん研究奨励賞（林原賞・山田賞）

タイトル（別表記）	The 2015 Incentive Award of the Okayama Medical Association in Cancer Research (2015 Hayashibara Prize and Yamada Prize)
フルテキストURL	128_99.pdf
著者	團迫浩方\|
出版物タイトル	岡山医学会雑誌
発行日	2016-08-01
巻	128巻
号	2号
開始ページ	99
終了ページ	102
ISSN	0030-1558
関連URL	https://doi.org/10.4044/joma.128.99
言語	日本語
著作権者	Copyright (c) 2016 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.128.99
NAID	130005262636

平成27年度岡山医学会賞総合研究奨励賞（結城賞）

タイトル（別表記）	The 2015 Incentive Award of the Okayama Medical Association in General Medical Science (2015 Yuuki Prize)
フルテキストURL	128_91.pdf
著者	梶田藍\|
出版物タイトル	岡山医学会雑誌
発行日	2016-08-01
巻	128巻
号	2号
開始ページ	91
終了ページ	94
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.128.91
言語	日本語
著作権者	Copyright (c) 2016 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.128.91
NAID	130005262638

Rab13 Is Involved in the Entry Step of Hepatitis C Virus Infection

JaLCDOI	10.18926/AMO/54190
フルテキストURL	70_2_111.pdf
著者	Takeda, Midori\| Ikeda, Masanori\| Satoh, Shinya\| Dansako, Hiromichi\| Wakita, Takaji\| Kato, Nobuyuki\|
抄録	Membrane transport probably participates in the lifecycle of hepatitis C virus (HCV). Rab proteins are essential host factors for HCV RNA replication, but these proteins’ roles in other steps of the HCV lifecycle are not clear. The tight junction (TJ) plays a key role in HCV infection. Rab13 regulates the endocytic recycling of the TJ-associated proteins. Here we investigated whether Rab13 is involved in the HCV entry step. We used HuH-7-derived RSc cells and Li23-derived D7 cells. To evaluate the effect of Rab13 in HCV infection, we transfected the cells with siRNA targeting Rab13 before HCV infection. The down-regulation of Rab13 inhibited HCV infection. The D7 cells had showed a greater inhibitory effect against HCV infection compared to that in the RSc cells by Rab13 knockdown. Next, to evaluate the effect of Rab13 after infection, we inoculated the cells with HCV before transfection of the siRNA. The down-regulation of Rab13 did not show any effects after HCV infection. We further examined whether Rab13 would influence HCV RNA replication by using HCV replicon-harboring cells. The results revealed that Rab13 did not affect the step of HCV RNA replication. These results suggest that Rab13 plays an important role in the step of HCV entry.
キーワード	hepatitis C virus Rab13 occludin claudin 1
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-04
巻	70巻
号	2号
出版者	Okayama University Medical School
開始ページ	111
終了ページ	118
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27094836
Web of Science KeyUT	000377626300006

Molecular Mechanism Underlying the Suppression of CPB2 Expression Caused by Persistent Hepatitis C Virus RNA Replication

JaLCDOI	10.18926/AMO/54186
フルテキストURL	70_2_75.pdf
著者	Sejima, Hiroe\| Satoh, Shinya\| Dansako, Hiromichi\| Honda, Masao\| Kaneko, Shuichi\| Ikeda, Masanori\| Kato, Nobuyuki\|
抄録	The mechanisms of hepatitis C virus (HCV)-associated hepatocarcinogenesis and disease progression are unclear. We previously observed that the expression level of carboxypeptidase B2 (CPB2) gene was remarkably suppressed by persistent HCV RNA replication in human hepatoma cell line Li23-derived cells. The results of the present study demonstrated that the CPB2 expression in patients with chronic hepatitis C was inversely correlated with several risk factors of hepatic fibrosis or steatosis, although ectopic CPB2 expression did not suppress the expression of fibrogenic or lipogenic genes. The suppressed CPB2 expression was restored by treatment with 5-azacytidine. To clarify the mechanism underlying this phenomenon, we analyzed the CPB2 promoter, and the results revealed that (1) hepatocyte nuclear factor 1 (HNF1), especially HNF1α, was essential for the CPB2 promoter, and (2) CPB2 promoter was not methylated by persistent HCV RNA replication. The expression levels of HNF1α and HNF1β were also not changed by persistent HCV RNA replication. These results suggest the existence of 5-azacytidine-inducible or -reducible unknown factor(s) that can control the CPB2 expression. To evaluate this idea we performed a microarray analysis, and several gene candidates corresponding to the suggested factor(s) were identified.
キーワード	persistent hepatitis C virus replication carboxypeptidase B2 suppression mechanism of CPB2 expression DNA methylation hepatocyte nuclear factor 1
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-04
巻	70巻
号	2号
出版者	Okayama University Medical School
開始ページ	75
終了ページ	88
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27094832
Web of Science KeyUT	000377626300002

Genetic Characterization of Hepatitis C Virus in Long-Term RNA Replication Using Li23 Cell Culture Systems

著者	Kato, Nobuyuki\| Sejima, Hiroe\| Ueda, Youki\| Mori, Kyoko\| Satoh, Shinya\| Dansako, Hiromichi\| Ikeda, Masanori\|
発行日	2014-03-13
出版物タイトル	PLOS ONE
巻	9巻
号	3号
資料タイプ	学術雑誌論文

New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication

著者	Ueda, Youki\| Takeda, Midori\| Mori, Kyoko\| Dansako, Hiromichi\| Wakita, Takaji\| Kim, Hye-Sook\| Sato, Akira\| Wataya, Yusuke\| Ikeda, Masanori\| Kato, Nobuyuki\|
発行日	2013-08-30
出版物タイトル	PLOS ONE
巻	8巻
号	8号
資料タイプ	学術雑誌論文

第56回日本臨床ウイルス学会開催報告

タイトル（別表記）	The 56th Annual Meeting of the Japanese Society for Clinical Virology
フルテキストURL	127_261.pdf
著者	山田雅夫\|
出版物タイトル	岡山医学会雑誌
発行日	2015-12-01
巻	127巻
号	3号
開始ページ	261
終了ページ	262
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.127.261
言語	日本語
著作権者	Copyright (c) 2015 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.127.261
NAID	130005116805

Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor

JaLCDOI	10.18926/AMO/53674
フルテキストURL	69_5_279.pdf
著者	Saito, Yukie\| Fujii, Yousuke\| Yashiro, Masato\| Tsuge, Mitsuru\| Nosaka, Nobuyuki\| Yamashita, Nobuko\| Yamada, Mutsuko\| Tsukahara, Hirokazu\| Morishima, Tsuneo\|
抄録	Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established. We examined the effects of edaravone, dexamethasone, and N-monomethyl-L-arginine (L-NMMA) on permeability changes in human pulmonary microvascular endothelial cells (PMVEC) under a hypercytokinemic state. Human PMVEC were seeded in a Boyden chamber. After monolayer confluence was achieved, the culture media were replaced respectively by culture media containing edaravone, dexamethasone, and L-NMMA. After 24-h incubation, the monolayer was stimulated with tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Fluorescein-labeled dextran was added. Then the trans-human PMVEC leak was measured. Expressions of vascular endothelial-cadherin (VE-cadherin) and zonula occludens-1 protein (ZO-1) were evaluated using real-time quantitative polymerase chain reaction and immunofluorescence microscopy. The results showed that TNF-α＋IL-1β markedly increased pulmonary microvascular permeability. Pretreatment with edaravone, dexamethasone, or L-NMMA attenuated the hyperpermeability and inhibited the cytokine-induced reduction of VE-cadherin expression on immunofluorescence staining. Edaravone and dexamethasone increased the expression of ZO-1 at both the mRNA and protein levels. Edaravone and dexamethasone inhibited the permeability changes of human PMVEC, at least partly through an enhancement of VE-cadherin. Collectively, these results suggest a potential therapeutic approach for intervention in patients with ARDS.
キーワード	pulmonary microvascular endothelial cells permeability edaravone vascular endothelial-cadherin zonula occludens-1 protein
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-10
巻	69巻
号	5号
出版者	Okayama University Medical School
開始ページ	279
終了ページ	290
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26490025
Web of Science KeyUT	000365519600004

The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly

著者	Dansako, Hiromichi\| Ueda, Youki\| Okumura, Nobuaki\| Satoh, Shinya\| Sugiyama, Masaya\| Mizokami, Masashi\| Ikeda, Masanori\| Kato, Nobuyuki\|
発行日	2015
出版物タイトル	The FEBS journal
資料タイプ	学術雑誌論文

Effectiveness of Extending Treatment Duration in Therapy with Pegylated Interferon and Ribavirin for Genotype 2 Hepatitis C Virus Infection

JaLCDOI	10.18926/AMO/53560
フルテキストURL	69_4_237.pdf
著者	Nanba, Shintarou\| Ikeda, Fusao\| Fujioka, Shin-ichi\| Araki, Yasuyuki\| Takaguchi, Kouichi\| Hashimoto, Noriaki\| Seki, Hiroyuki\| Takaki, Akinobu\| Iwasaki, Yoshiaki\| Yamamoto, Kazuhide\|
抄録	The effectiveness of extending treatment duration as response guided therapy was previously reported for chronic hepatitis C (CHC) genotype 1, but is still controversial for genotype 2. The present study is a retrospective cohort study to investigate the effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for patients with CHC genotype 2 by focusing on the timing at which patients obtained undetectable HCV RNA. A total of 306 patients who obtained undetectable HCV RNA by week 24 of treatment and completed 24 weeks of treatment were enrolled. Rapid virological response (RVR) to standard therapy was achieved by 122 patients (51ｵ), and 89ｵ of them obtained sustained virological response (SVR), while 69ｵ of non-RVR patients achieved SVR. Non-RVR patients with undetectable HCV RNA at week 8, and insufficient adherence＜80ｵ pegylated interferon and ribavirin during the first 24 weeks, significantly improved their SVR rate by extended therapy. Among patients receiving extended therapy, drug adherences did not differ between SVR and non-SVR patients, indicating that extending treatment duration might compensate for insufficient antiviral effects due to insufficient drug adherences. This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2.
キーワード	hepatitis C virus interferon genotype 2 response-guided therapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2015-08
巻	69巻
号	4号
出版者	Okayama University Medical School
開始ページ	237
終了ページ	244
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	26289915
Web of Science KeyUT	000365519100007