start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=1
article-no=
start-page=364
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250513
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Efficient diagnosis for endoscopic remission in Crohn's diseases by the combination of three non-invasive markers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Serum C-reactive protein (CRP), leucine-rich alpha-2 glycoprotein (LRG), and fecal calprotectin (Fcal) are non-invasive markers used to assess Crohn's disease (CD) severity. However, the accuracy of these markers alone is often limited, and most previous reports have evaluated the efficacy of each marker individually. We aimed to improve the diagnostic performance of endoscopic remission (ER) of CD by combining these 3 markers.<br>
Methods We tested the diagnostic ability of various combinations of these 3 markers for endoscopic severity in 230 consecutive patients with CD from September 2014 to July 2023. The modified Simple Endoscopic Score for Crohn's disease (mSES-CD) was used to determine endoscopic severity.<br>
Results Each of the 3 markers was correlated with mSED-CD (LRG: r = 0.69, CRP: r = 0.60, and Fcal: r = 0.67). A combination of 2 of the 3 markers did not increase the diagnostic accuracy of ER. However, by combining all 3 markers, the diagnostic ability for ER was improved in comparison to the diagnostic ability of the 3 individual markers, assuming that ER was obtained if 2 or 3 markers were negative. The sensitivity, specificity, and accuracy were 89%, 83%, and 86%, respectively. Additionally, we established a 2-step method using Fcal values after evaluating the 2 serum markers. This method was most useful for reducing both the patient burden and costs.<br>
Conclusions The newly established 2-step method allowed for a higher accuracy in the non-invasive diagnosis of ER when the 3 markers were combined.
en-copyright=
kn-copyright=

en-aut-name=TakeiKensuke
en-aut-sei=Takei
en-aut-mei=Kensuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=InokuchiToshihiro
en-aut-sei=Inokuchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HiraokaSakiko
en-aut-sei=Hiraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiguroMikako
en-aut-sei=Ishiguro
en-aut-mei=Mikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ToyosawaJunki
en-aut-sei=Toyosawa
en-aut-mei=Junki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AoyamaYuki
en-aut-sei=Aoyama
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IgawaShoko
en-aut-sei=Igawa
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakeuchiKeiko
en-aut-sei=Takeuchi
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamasakiYasushi
en-aut-sei=Yamasaki
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KinugasaHideaki
en-aut-sei=Kinugasa
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TakaharaMasahiro
en-aut-sei=Takahara
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KawanoSeiji
en-aut-sei=Kawano
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=OtsukaMotoyuki
en-aut-sei=Otsuka
en-aut-mei=Motoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Research Center for Intestinal Health Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=14
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=CD, Crohn's disease
kn-keyword=CD, Crohn's disease
en-keyword=LRG, Leucine-rich alpha-2 glycoprotein
kn-keyword=LRG, Leucine-rich alpha-2 glycoprotein
en-keyword=Fcal, Fecal calprotectin
kn-keyword=Fcal, Fecal calprotectin
en-keyword=CRP, C-reactive protein
kn-keyword=CRP, C-reactive protein
en-keyword=ER, Endoscopic remission
kn-keyword=ER, Endoscopic remission
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=3
article-no=
start-page=185
end-page=195
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202506
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Emotional Changes among Young Patients with Breast Cancer to Foster Relationship-Building with Their Partners: A Qualitative Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated the emotional changes that young patients with breast cancer need to undergo in order to foster relationship-building with their partners by conducting a qualitative descriptive study (March 1 to Nov. 26, 2021) and semi-structured interviews with eight postoperative patients (age 20-40 years) with breast cancer. The data were analyzed using the modified grounded theory approach (M-GTA), yielding five categories: (i) Awareness of being a breast cancer patient, (ii) Being at a loss, (iii) Support from significant others, (iv) The struggle to transition from being a patient with cancer to becoming “the person I want to be”, and (v) Reaching the “me” I want to be who can face building a relationship with a partner. These findings suggest that young breast cancer patients must feel that they can lead a normal life through activities such as work or acquiring qualifications before building relationships with their partners, and that getting closer to their desired selves is important. Nurses can provide information to young patients with breast cancer to assist them in building a solid relationship with their partners. We believe that this support may enhance the patients’ quality of life and help them achieve stronger relationships with their partners.
en-copyright=
kn-copyright=

en-aut-name=YoshikawaAyumi
en-aut-sei=Yoshikawa
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TairaNaruto
en-aut-sei=Taira
en-aut-mei=Naruto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkanagaMayumi
en-aut-sei=Okanaga
en-aut-mei=Mayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SaitoShinya
en-aut-sei=Saito
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Faculty of Nursing, Osaka Dental University
kn-affil=

affil-num=2
en-affil=Kawasaki Medical School, Department of Breast and Thyroid Surgery
kn-affil=

affil-num=3
en-affil=Gifu College of Nursing, Nursing of Children and Child-Rearing Families
kn-affil=

affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=breast cancer patient
kn-keyword=breast cancer patient
en-keyword=young patient
kn-keyword=young patient
en-keyword=single
kn-keyword=single
en-keyword=partners
kn-keyword=partners
en-keyword=relationships
kn-keyword=relationships
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=3
article-no=
start-page=147
end-page=155
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202506
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Immunometabolic Regulation of Innate Immunity in Systemic Lupus Erythematosus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes.
en-copyright=
kn-copyright=

en-aut-name=WatanabeHaruki
en-aut-sei=Watanabe
en-aut-mei=Haruki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoYoshinori
en-aut-sei=Matsumoto
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=systemic lupus erythematosus
kn-keyword=systemic lupus erythematosus
en-keyword=interferon
kn-keyword=interferon
en-keyword=tricarboxylic acid cycle
kn-keyword=tricarboxylic acid cycle
en-keyword=innate immune memory
kn-keyword=innate immune memory
en-keyword=trained immunity
kn-keyword=trained immunity
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=2
article-no=
start-page=109
end-page=116
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202504
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Relationship between Personality Traits and Postpartum Depressive Symptoms in Women who Became Pregnant via Infertility Treatment
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The status of postpartum depression was elucidated herein with the use of the Edinburgh Postnatal Depression Scale (EPDS) in women in Shikoku, Japan who became pregnant and gave birth after undergoing infertility treatment, including assisted reproductive technology (ART). The assessment was performed during their children’s 4-month health examination. The relationships between postpartum depression and the mothers’ background factors and scores on the Big Five personality traits scale were also examined. Of the Big Five personality traits, the scores for neuroticism were significantly higher in the ART group (n=71) than in the general infertility treatment (n=118) and natural pregnancy (n=872) groups. No significant differences in EPDS scores were seen among these three groups. A logistic regression analysis showed that neuroticism was associated with an EPDS score ≧9 points, (which is suggestive of postpartum depression, ) in all groups. Moreover, although a long-standing marriage had an inhibitory effect on postpartum depression in the natural pregnancy group, no such trend was seen in the ART group, which included many women with long-standing marriages. Particularly for women who become pregnant by ART, an individualized response that pays close attention to the woman’s personality traits is needed.
en-copyright=
kn-copyright=

en-aut-name=AwaiKyoko
en-aut-sei=Awai
en-aut-mei=Kyoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakatsukaMikiya
en-aut-sei=Nakatsuka
en-aut-mei=Mikiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=
en-keyword=infertility treatment
kn-keyword=infertility treatment
en-keyword=assisted reproductive technology
kn-keyword=assisted reproductive technology
en-keyword=postpartum
kn-keyword=postpartum
en-keyword=postpartum depression
kn-keyword=postpartum depression
en-keyword=personality trait
kn-keyword=personality trait
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=7
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202502
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Endothelial Cell Polarity in Health and Disease
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Endothelial cell polarity is fundamental to the organization and function of blood vessels, influencing processes such as angiogenesis, vascular stability, and response to shear stress. This review elaborates on the molecular mechanisms that regulate endothelial cell polarity, focusing on key players like the PAR polarity complex and Rho family GTPases. These pathways coordinate the front–rear, apical–basal and planar polarity of endothelial cells, which are essential for the proper formation and maintenance of vascular structures. In health, endothelial polarity ensures not only the orderly development of blood vessels, with tip cells adopting distinct polarities during angiogenesis, but also ensures proper vascular integrity and function. In disease states, however, disruptions in polarity contribute to pathologies such as coronary artery disease, where altered planar polarity exacerbates atherosclerosis, and cancer, where disrupted polarity in tumor vasculature leads to abnormal vessel growth and function. Understanding cell polarity and its disruption is fundamental not only to comprehending how cells interact with their microenvironment and organize themselves into complex, organ-specific tissues but also to developing novel, targeted, and therapeutic strategies for a range of diseases, from cardiovascular disorders to malignancies, ultimately improving patient outcomes.
en-copyright=
kn-copyright=

en-aut-name=ThihaMoe
en-aut-sei=Thiha
en-aut-mei=Moe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HikitaTakao
en-aut-sei=Hikita
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakayamaMasanori
en-aut-sei=Nakayama
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Pathophysiology and Drug Discovery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Pathophysiology and Drug Discovery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Pathophysiology and Drug Discovery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=blood vessel
kn-keyword=blood vessel
en-keyword=endothelial cell
kn-keyword=endothelial cell
en-keyword=cell polarity
kn-keyword=cell polarity
en-keyword=atherosclerosis
kn-keyword=atherosclerosis
en-keyword=cancer
kn-keyword=cancer
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=2485
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250120
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cesarean delivery on child health and development in Japanese nationwide birth cohort
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The long-term effects of cesarean delivery (CD) on child health and development remain controversial. This study aimed to investigate these effects using an outcome-wide approach in a Japanese context, where perinatal mortality rates are among the world's lowest. We analyzed data from 2,114 children in a nationwide Japanese birth cohort, linking the 21st Century Longitudinal Survey of Newborns with the Perinatal Research Network database. We examined associations between CD and various health and developmental outcomes up to 9 years of age, including hospitalizations, obesity, and developmental milestones. After adjusting for potential confounders, CD was not significantly associated with most outcomes, including all-cause hospitalization (adjusted risk ratio 1.25, 95% CI 0.997-1.56), obesity at 5.5 and 9 years, and various developmental milestones. Subgroup analyses for multiple births and preterm infants showed some differences in point estimates, but were limited by small sample sizes. CD was not significantly associated with adverse long-term child health or developmental outcomes in this Japanese cohort. These findings provide reassurance regarding CD safety when medically indicated in advanced perinatal care settings. Further research with larger samples and longer follow-up is needed, especially for specific subgroups.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoNaomi
en-aut-sei=Matsumoto
en-aut-mei=Naomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MitsuiTakashi
en-aut-sei=Mitsui
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TamaiKei
en-aut-sei=Tamai
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HirotaTomoya
en-aut-sei=Hirota
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MasuyamaHisashi
en-aut-sei=Masuyama
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Division of Neonatology, NHO Okayama Medical Center
kn-affil=

affil-num=4
en-affil=Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California San Francisco
kn-affil=

affil-num=5
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Cesarean delivery
kn-keyword=Cesarean delivery
en-keyword=Delivery methods
kn-keyword=Delivery methods
en-keyword=Long-term outcome
kn-keyword=Long-term outcome
en-keyword=Child development
kn-keyword=Child development
en-keyword=Outcome-wide approach
kn-keyword=Outcome-wide approach
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=2
article-no=
start-page=e70168
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Crowned Dens Syndrome Triggered by Dental Treatment
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Crowned dens syndrome (CDS) is an important yet often overlooked cause of fever and neck pain, frequently leading to unnecessary examinations and treatments and misdiagnosis as infectious diseases or rheumatic diseases. The mechanism of an acute attack of CDS is not clarified completely, while it is considered that severe systemic stress can trigger inflammation caused by calcium pyrophosphate crystals. We describe a case of CDS triggered by localized physical stress to the neck and emphasize the importance of considering this condition in cases of fever and neck pain following dental treatment.
en-copyright=
kn-copyright=

en-aut-name=MoritaSatoru
en-aut-sei=Morita
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OtsukaYuki
en-aut-sei=Otsuka
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MasudaYohei
en-aut-sei=Masuda
en-aut-mei=Yohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SoejimaYoshiaki
en-aut-sei=Soejima
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=calcium pyrophosphate crystal deposition disease
kn-keyword=calcium pyrophosphate crystal deposition disease
en-keyword=crowned dens syndrome
kn-keyword=crowned dens syndrome
en-keyword=dental treatment
kn-keyword=dental treatment
en-keyword=fever
kn-keyword=fever
en-keyword=neck pain
kn-keyword=neck pain
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=5
article-no=
start-page=413
end-page=421
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Focal Cerebral Hypoperfusion Detected by Arterial Spin-Labeled Magnetic Resonance Imaging in Patients with Migraine Presenting with Neurological Symptoms Concomitant with or without Headache
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated patients with migraine or migraine variants who exhibited focal cerebral hypoperfusion on arterial spin-labeled (ASL) magnetic resonance (MR) imaging along with neurological symptoms. Fourteen patients with migraine demonstrated focal cerebral hypoperfusion. Three other patients did not have a history of recurrent headaches but exhibited comparable cerebral hypoperfusion to migraine patients on ASL-MRI in addition to neurological symptoms. Patients with migraine may present with neurological symptoms associated with cortical spreading depression during, after, or even without a headache phase. Additionally, the isolated neurological symptoms may be caused by a pathophysiology identical to that of migraine but without presenting with recurrent headaches.
en-copyright=
kn-copyright=

en-aut-name=KashiharaKenichi
en-aut-sei=Kashihara
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IrisawaMinoru
en-aut-sei=Irisawa
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakaoWataru
en-aut-sei=Takao
en-aut-mei=Wataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Okayama Neurology Clinic
kn-affil=

affil-num=2
en-affil=Department of Radiology, Okayama Kyokuto Hospital
kn-affil=

affil-num=3
en-affil=Division of Radiology, Okayama Kyokuto Hospital
kn-affil=
en-keyword=arterial spin-labeled magnetic resonance imaging
kn-keyword=arterial spin-labeled magnetic resonance imaging
en-keyword=cortical spreading depression
kn-keyword=cortical spreading depression
en-keyword=migraine complex
kn-keyword=migraine complex
en-keyword=migraine without headache
kn-keyword=migraine without headache
en-keyword=vertigo
kn-keyword=vertigo
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=5
article-no=
start-page=357
end-page=362
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Factors Affecting Dynamic Postural Control Ability in Adolescent Idiopathic Scoliosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Research on postural control in patients with adolescent idiopathic scoliosis (AIS) has focused on static postural control, with few studies assessing dynamic postural control. We aimed to identify factors affecting index of postural stability (IPS), a dynamic postural control parameter, in patients with AIS. The participants comprised 50 female patients with AIS. We measured the IPS using stabilometry to evaluate dynamic postural control ability. We investigated age of the participants, major curve position (thoracic or thoracolumbar/lumbar), Cobb angle, and coronal balance. We then assessed the relationships between stabilometry parameters and other variables. IPS was analyzed with a linear regression model. Coronal balance, major curve position, and age each correlated with dynamic postural control ability. The Cobb angle showed no correlation with any of the parameters. Our results offer new insights into the assessment of postural control in patients with AIS.
en-copyright=
kn-copyright=

en-aut-name=YamawakiRyoko
en-aut-sei=Yamawaki
en-aut-mei=Ryoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OdaYoshiaki
en-aut-sei=Oda
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamaneShuhei
en-aut-sei=Yamane
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UotaniKoji
en-aut-sei=Uotani
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MisawaHaruo
en-aut-sei=Misawa
en-aut-mei=Haruo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KatayamaYoshimi
en-aut-sei=Katayama
en-aut-mei=Yoshimi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HamadaMasanori
en-aut-sei=Hamada
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University
kn-affil=

affil-num=5
en-affil=Ryusoh Orthopaedic Hospital
kn-affil=

affil-num=6
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=

affil-num=7
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=

affil-num=8
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=
en-keyword=adolescent idiopathic scoliosis
kn-keyword=adolescent idiopathic scoliosis
en-keyword=postural control
kn-keyword=postural control
en-keyword=coronal balance
kn-keyword=coronal balance
en-keyword=index of postural stability
kn-keyword=index of postural stability
en-keyword=stabilometry
kn-keyword=stabilometry
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=17
article-no=
start-page=2824
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240823
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cyclic Oligosaccharide-Induced Modulation of Immunoglobulin A Reactivity to Gut Bacteria Contributes to Alterations in the Bacterial Community Structure
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Immunoglobulin A (IgA) is a major gut antibody that coats commensal gut bacteria and contributes to shaping a stable gut bacterial composition. Although previous studies have shown that cyclic oligosaccharides, including cyclic nigerosyl-1,6-nigerose (CNN) and cyclodextrins (CDs, including alpha CD, beta CD, and gamma CD), alter the gut bacterial composition, it remains unclear whether cyclic oligosaccharides modify the IgA coating of gut bacteria, which relates to cyclic oligosaccharide-induced alteration of the gut bacterial composition. To address this issue, mice were maintained for 12 weeks on diets containing CNN, alpha CD, beta CD, or gamma CD; the animals' feces were evaluated for their bacterial composition and the IgA coating index (ICI), a measure of the degree of IgA coating of bacteria. We observed that the intake of each cyclic oligosaccharide altered the gut bacterial composition, with changes in the ICI found at both the phylum and genus levels. The ICI for Bacillota, Lachnospiraceae NK4A136 group, UC Lachnospiraceae, and Tuzzerella were significantly and positively correlated with the relative abundance (RA) in total bacteria for these bacteria; in contrast, significant correlations were not seen for other phyla and genera. Our observations suggest that cyclic oligosaccharide-induced modulation of the IgA coating of gut bacteria may partly relate to changes in the community structure of the gut bacteria.
en-copyright=
kn-copyright=

en-aut-name=MiyamotoTaisei
en-aut-sei=Miyamoto
en-aut-mei=Taisei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TsurutaTakeshi
en-aut-sei=Tsuruta
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TeraokaMao
en-aut-sei=Teraoka
en-aut-mei=Mao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WangTianyang
en-aut-sei=Wang
en-aut-mei=Tianyang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishinoNaoki
en-aut-sei=Nishino
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=cyclic oligosaccharides
kn-keyword=cyclic oligosaccharides
en-keyword=gut bacteria
kn-keyword=gut bacteria
en-keyword=immunoglobulin A
kn-keyword=immunoglobulin A
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=32
article-no=
start-page=12686
end-page=12694
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Boosting charge separation in organic photovoltaics: unveiling dipole moment variations in excited non-fullerene acceptor layers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The power conversion efficiency (PCE) of organic photovoltaics (OPVs) has reached more than 19% due to the rapid development of non-fullerene acceptors (NFAs). To compete with the PCEs (26%) of commercialized silicon-based inorganic photovoltaics, the drawback of OPVs should be minimized. This drawback is the intrinsic large loss of open-circuit voltage; however, a general approach to this issue remains elusive. Here, we report a discovery regarding highly efficient NFAs, specifically ITIC. We found that charge-transfer (CT) and charge dissociation (CD) can occur even in a neat ITIC film without the donor layer. This is surprising, as these processes were previously believed to take place exclusively at donor/acceptor heterojunctions. Femtosecond time-resolved visible to mid-infrared measurements revealed that in the neat ITIC layers, the intermolecular CT immediately proceeds after photoirradiation (<0.1 ps) to form weakly-bound excitons with a binding energy of 0.3 eV, which are further dissociated into free electrons and holes with a time-constant of 56 ps. Theoretical calculations indicate that stacking faults in ITIC (i.e., V-type molecular stacking) induce instantaneous intermolecular CT and CD in the neat ITIC layer. In contrast, J-type stacking does not support such CT and CD. This previously unknown pathway is triggered by the larger dipole moment change on the excited state generated at the lower symmetric V-type molecular stacking of ITIC. This is in sharp contrast with the need of sufficient energy offset for CT and CD at the donor-acceptor heterojunction, leading to the significant voltage loss in conventional OPVs. These results demonstrate that the rational molecular design of NFAs can increase the local dipole moment change on the excited state within the NFA layer. This finding paves the way for a groundbreaking route toward the commercialization of OPVs.
en-copyright=
kn-copyright=

en-aut-name=YamakataAkira
en-aut-sei=Yamakata
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KatoKosaku
en-aut-sei=Kato
en-aut-mei=Kosaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UrakamiTakumi
en-aut-sei=Urakami
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsujimuraSota
en-aut-sei=Tsujimura
en-aut-mei=Sota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MurayamaKasumi
en-aut-sei=Murayama
en-aut-mei=Kasumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HigashiMasahiro
en-aut-sei=Higashi
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SatoHirofumi
en-aut-sei=Sato
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KoboriYasuhiro
en-aut-sei=Kobori
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=UmeyamaTomokazu
en-aut-sei=Umeyama
en-aut-mei=Tomokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ImahoriHiroshi
en-aut-sei=Imahori
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
kn-affil=

affil-num=4
en-affil=Department of Chemistry, Graduate School of Science, Kobe University
kn-affil=

affil-num=5
en-affil=Department of Chemistry, Graduate School of Science, Kobe University
kn-affil=

affil-num=6
en-affil=Department of Complex Systems Science, Graduate School of Informatics, Nagoya University
kn-affil=

affil-num=7
en-affil=Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
kn-affil=

affil-num=8
en-affil=Department of Chemistry, Graduate School of Science, Kobe University
kn-affil=

affil-num=9
en-affil=Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo
kn-affil=

affil-num=10
en-affil=Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=15139
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240702
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genetic background influences mineral accumulation in rice straw and grains under different soil pH conditions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mineral element accumulation in plants is influenced by soil conditions and varietal factors. We investigated the dynamic accumulation of 12 elements in straw at the flowering stage and in grains at the mature stage in eight rice varieties with different genetic backgrounds (Japonica, Indica, and admixture) and flowering times (early, middle, and late) grown in soil with various pH levels. In straw, Cd, As, Mn, Zn, Ca, Mg, and Cu accumulation was influenced by both soil pH and varietal factors, whereas P, Mo, and K accumulation was influenced by pH, and Fe and Ni accumulation was affected by varietal factors. In grains, Cd, As, Mn, Cu, Ni, Mo, Ca, and Mg accumulation was influenced by both pH and varietal factors, whereas Zn, Fe, and P accumulation was affected by varietal factors, and K accumulation was not altered. Only As, Mn, Ca and Mg showed similar trends in the straw and grains, whereas the pH responses of Zn, P, K, and Ni differed between them. pH and flowering time had synergistic effects on Cd, Zn, and Mn in straw and on Cd, Ni, Mo, and Mn in grains. Soil pH is a major factor influencing mineral uptake in rice straw and grains, and genetic factors, flowering stage factors, and their interaction with soil pH contribute in a combined manner.
en-copyright=
kn-copyright=

en-aut-name=YamamotoToshio
en-aut-sei=Yamamoto
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KashiharaKazunari
en-aut-sei=Kashihara
en-aut-mei=Kazunari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FurutaTomoyuki
en-aut-sei=Furuta
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ZhangQian
en-aut-sei=Zhang
en-aut-mei=Qian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YuEn
en-aut-sei=Yu
en-aut-mei=En
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MaJian Feng
en-aut-sei=Ma
en-aut-mei=Jian Feng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=6
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=123
end-page=134
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sigle Agent of Posttransplant Cyclophosphamide Without Calcineurin Inhibitor Controls Severity of Experimental Chronic GVHD
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT.
en-copyright=
kn-copyright=

en-aut-name=SaekiKyosuke
en-aut-sei=Saeki
en-aut-mei=Kyosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraHideaki
en-aut-sei=Fujiwara
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SeikeKeisuke
en-aut-sei=Seike
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KuroiTaiga
en-aut-sei=Kuroi
en-aut-mei=Taiga
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishimoriHisakazu
en-aut-sei=Nishimori
en-aut-mei=Hisakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsuokaKen-ichi
en-aut-sei=Matsuoka
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=FujiiNobuharu
en-aut-sei=Fujii
en-aut-mei=Nobuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Hematology and Oncology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Hematology and Oncology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Hematology and Oncology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Division of Transfusion, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=GVHD
kn-keyword=GVHD
en-keyword=posttransplant cyclophosphamide
kn-keyword=posttransplant cyclophosphamide
en-keyword=hematopoietic cell transplantation
kn-keyword=hematopoietic cell transplantation
en-keyword=HLA-identical
kn-keyword=HLA-identical
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Role of Macrophages in Liver Fibrosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis.
en-copyright=
kn-copyright=

en-aut-name=SunCuiming
en-aut-sei=Sun
en-aut-mei=Cuiming
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsukawaAkihiro
en-aut-sei=Matsukawa
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Pathology and Experimental Medicine, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Pathology and Experimental Medicine, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=ERK-MAPK
kn-keyword=ERK-MAPK
en-keyword=SPRED2
kn-keyword=SPRED2
en-keyword=fibrosis
kn-keyword=fibrosis
en-keyword=macrophages
kn-keyword=macrophages
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=6
article-no=
start-page=635
end-page=645
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202312
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Nutritional Support Combined with Neuromuscular Electrical Stimulation on Muscle Strength and Thickness: A Randomized Controlled Trial in Healthy Young Adult Males
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted.
en-copyright=
kn-copyright=

en-aut-name=IkedaTomohiro
en-aut-sei=Ikeda
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkamuraKazunori
en-aut-sei=Okamura
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HasegawaMasaki
en-aut-sei=Hasegawa
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanakaSatoshi
en-aut-sei=Tanaka
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KanaiShusaku
en-aut-sei=Kanai
en-aut-mei=Shusaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Rehabilitation Medicine, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=

affil-num=3
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=

affil-num=4
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=

affil-num=5
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=
en-keyword=whey protein
kn-keyword=whey protein
en-keyword=electrical stimulation
kn-keyword=electrical stimulation
en-keyword=muscle strength
kn-keyword=muscle strength
en-keyword=healthy volunteers
kn-keyword=healthy volunteers
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=6
article-no=
start-page=619
end-page=625
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202312
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Trochanteric Claw Plate Fixation for Greater Trochanteric Fracture or Osteotomy in Total Hip Arthroplasty
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study retrospectively evaluated 41 consecutive open reductions and internal fixations following primary or revision total hip arthroplasty, which required trochanteric claw plate fixation for greater trochanteric fracture or osteotomy between January 2008 and December 2020. The mean duration of clinical follow-up was 4.2 years (range, 1-13 years). The patients included 13 men and 28 women, with a mean age of 68 years (range, 32-87 years). The indications for intervention included trochanteric osteotomy, intraoperative fracture, and non-union including postoperative fracture in 6, 9, and 26 cases, respectively. The mean Merle d’Aubigné Clinical Score improved from 9.4 points (range, 5-15 points) pre-operatively, to 14.3 points (range, 9-18 points) at the last follow-up. Bone union occurred in 35 cases (85%), while implant breakage occurred in four cases. At the last follow-up, the mean Merle d’Aubigné Clinical Scores of bone union and non-union were 15.3 and 14.1, respectively (p=0.48). The Kaplan-Meier survival rate, with the endpoint being revision surgery for pain, non-union, dislocation, or implant breakage, at 10 years was 80.0% (95% confidence interval: 62.6-97.4%). Greater trochanteric fixation using a trochanteric claw plate yielded successful results.
en-copyright=
kn-copyright=

en-aut-name=OeKenichi
en-aut-sei=Oe
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IidaHirokazu
en-aut-sei=Iida
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SogawaShohei
en-aut-sei=Sogawa
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KobayashiFumito
en-aut-sei=Kobayashi
en-aut-mei=Fumito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraTomohisa
en-aut-sei=Nakamura
en-aut-mei=Tomohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SaitoTakanori
en-aut-sei=Saito
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Kansai Medical University
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Kansai Medical University
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Kansai Medical University
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Kansai Medical University
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Kansai Medical University
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Kansai Medical University
kn-affil=
en-keyword=greater trochanteric fracture
kn-keyword=greater trochanteric fracture
en-keyword=trochanteric osteotomy
kn-keyword=trochanteric osteotomy
en-keyword=claw plate
kn-keyword=claw plate
en-keyword=total hip arthroplasty
kn-keyword=total hip arthroplasty
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=6
article-no=
start-page=595
end-page=605
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202312
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Concomitant Use of Multiple Nephrotoxins including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity: Combined Retrospective Analyses of Two Real-World Databases
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN.
en-copyright=
kn-copyright=

en-aut-name=BandoTakashi
en-aut-sei=Bando
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ChumaMasayuki
en-aut-sei=Chuma
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HamanoHirofumi
en-aut-sei=Hamano
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NiimuraTakahiro
en-aut-sei=Niimura
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkadaNaoto
en-aut-sei=Okada
en-aut-mei=Naoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KondoMasateru
en-aut-sei=Kondo
en-aut-mei=Masateru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IzumiYuki
en-aut-sei=Izumi
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshidaShunsuke
en-aut-sei=Ishida
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YoshiokaToshihiko
en-aut-sei=Yoshioka
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=AsadaMizuho
en-aut-sei=Asada
en-aut-mei=Mizuho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=ZamamiYoshito
en-aut-sei=Zamami
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TakechiKenshi
en-aut-sei=Takechi
en-aut-mei=Kenshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=GodaMitsuhiro
en-aut-sei=Goda
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=MiyataKoji
en-aut-sei=Miyata
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=YagiKenta
en-aut-sei=Yagi
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=Izawa-IshizawaYuki
en-aut-sei=Izawa-Ishizawa
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=AzumaMomoyo
en-aut-sei=Azuma
en-aut-mei=Momoyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=YanagawaHiroaki
en-aut-sei=Yanagawa
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=TasakiYoshikazu
en-aut-sei=Tasaki
en-aut-mei=Yoshikazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=IshizawaKeisuke
en-aut-sei=Ishizawa
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

affil-num=1
en-affil=Department of Pharmacy, Tokushima University Hospital
kn-affil=

affil-num=2
en-affil=Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital
kn-affil=

affil-num=3
en-affil=Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences
kn-affil=

affil-num=4
en-affil=Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital
kn-affil=

affil-num=5
en-affil=Department of Pharmacy, Tokushima University Hospital
kn-affil=

affil-num=6
en-affil=Department of Pharmacy, Tokushima University Hospital
kn-affil=

affil-num=7
en-affil=Department of Pharmacy, Tokushima University Hospital
kn-affil=

affil-num=8
en-affil=Department of Pharmacy, Tokushima University Hospital
kn-affil=

affil-num=9
en-affil=Department of Pharmacy, Tokushima University Hospital
kn-affil=

affil-num=10
en-affil=Department of Medical Molecular Informatics, Meiji Pharmaceutical University
kn-affil=

affil-num=11
en-affil=Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences
kn-affil=

affil-num=12
en-affil=Department of Drug Information Analysis, College of Pharmaceutical Sciences, Matsuyama University
kn-affil=

affil-num=13
en-affil=Department of Pharmacy, Tokushima University Hospital
kn-affil=

affil-num=14
en-affil=Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences
kn-affil=

affil-num=15
en-affil=Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital
kn-affil=

affil-num=16
en-affil=Department of Pharmacology, Tokushima University Graduate School of Biomedical Sciences
kn-affil=

affil-num=17
en-affil=Department of Infection Control and Prevention, Tokushima University Hospital
kn-affil=

affil-num=18
en-affil=Department of Nursing, Faculty of Health and Welfare, Tokushima Bunri University
kn-affil=

affil-num=19
en-affil=Department of Hospital Pharmacy and Pharmacology, Asahikawa Medical University
kn-affil=

affil-num=20
en-affil=Department of Pharmacy, Tokushima University Hospital
kn-affil=
en-keyword=vancomycin-associated nephrotoxicity
kn-keyword=vancomycin-associated nephrotoxicity
en-keyword=polypharmacy
kn-keyword=polypharmacy
en-keyword=nephrotoxin
kn-keyword=nephrotoxin
en-keyword=spontaneous adverse event reporting database
kn-keyword=spontaneous adverse event reporting database
en-keyword=electronic medical records
kn-keyword=electronic medical records
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=5
article-no=
start-page=394
end-page=405
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230911
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Highly Stretchable Stress-Strain Sensor from Elastomer Nanocomposites with Movable Cross-links and Ketjenblack
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Practical applications like very thin stress-strain sensors require high strength, stretchability, and conductivity, simultaneously. One of the approaches is improving the toughness of the stress-strain sensing materials. Polymeric materials with movable cross-links in which the polymer chain penetrates the cavity of cyclodextrin (CD) demonstrate enhanced strength and stretchability, simultaneously. We designed two approaches that utilize elastomer nanocomposites with movable cross-links and carbon filler (ketjenblack, KB). One approach is mixing SC (a single movable cross-network material), a linear polymer (poly(ethyl acrylate), PEA), and KB to obtain their composite. The electrical resistance increases proportionally with tensile strain, leading to the application of this composite as a stress- strain sensor. The responses of this material are stable for over 100 loading and unloading cycles. The other approach is a composite made with KB and a movable cross-network elastomer for knitting dissimilar polymers (KP), where movable cross-links connect the CD-modified polystyrene (PSCD) and PEA. The obtained composite acts as a highly sensitive stress-strain sensor that exhibits an exponential increase in resistance with increasing tensile strain due to the polymer dethreading from the CD rings. The designed preparations of highly repeatable or highly responsive stress-strain sensors with good mechanical properties can help broaden their application in electrical devices.
en-copyright=
kn-copyright=

en-aut-name=IkuraRyohei
en-aut-sei=Ikura
en-aut-mei=Ryohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KajimotoKota
en-aut-sei=Kajimoto
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ParkJunsu
en-aut-sei=Park
en-aut-mei=Junsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurayamaShunsuke
en-aut-sei=Murayama
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiwaraYusei
en-aut-sei=Fujiwara
en-aut-mei=Yusei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OsakiMotofumi
en-aut-sei=Osaki
en-aut-mei=Motofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SuzukiTomohiro
en-aut-sei=Suzuki
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShirakawaHidenori
en-aut-sei=Shirakawa
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KitamuraYujiro
en-aut-sei=Kitamura
en-aut-mei=Yujiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TakahashiHiroaki
en-aut-sei=Takahashi
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OhashiYasumasa
en-aut-sei=Ohashi
en-aut-mei=Yasumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=ObataSeiji
en-aut-sei=Obata
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=HaradaAkira
en-aut-sei=Harada
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=IkemotoYuka
en-aut-sei=Ikemoto
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=NishinaYuta
en-aut-sei=Nishina
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=UetsujiYasutomo
en-aut-sei=Uetsuji
en-aut-mei=Yasutomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=MatsubaGo
en-aut-sei=Matsuba
en-aut-mei=Go
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=TakashimaYoshinori
en-aut-sei=Takashima
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

affil-num=1
en-affil=Department of Macromolecular Science, Graduate School of Science and Forefront Research Center for Fundamental Sciences, Osaka University
kn-affil=

affil-num=2
en-affil=Department of Macromolecular Science, Graduate School of Science, Osaka University
kn-affil=

affil-num=3
en-affil=Department of Macromolecular Science, Graduate School of Science and Forefront Research Center for Fundamental Sciences, Osaka University
kn-affil=

affil-num=4
en-affil=Graduate School of Organic Materials Engineering, Yamagata University
kn-affil=

affil-num=5
en-affil=Department of Mechanical Engineering, Osaka Institute of Technology
kn-affil=

affil-num=6
en-affil=Department of Macromolecular Science, Graduate School of Science and Forefront Research Center for Fundamental Sciences, Osaka University
kn-affil=

affil-num=7
en-affil=Kanagawa Technical Center, Yushiro Chemical Industry Co., Ltd.
kn-affil=

affil-num=8
en-affil=Kanagawa Technical Center, Yushiro Chemical Industry Co., Ltd.
kn-affil=

affil-num=9
en-affil=Kanagawa Technical Center, Yushiro Chemical Industry Co., Ltd.
kn-affil=

affil-num=10
en-affil=Kanagawa Technical Center, Yushiro Chemical Industry Co., Ltd.
kn-affil=

affil-num=11
en-affil=Kanagawa Technical Center, Yushiro Chemical Industry Co., Ltd.
kn-affil=

affil-num=12
en-affil=Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=SANKEN (The Institute of Scientific and Industrial Research), Osaka University
kn-affil=

affil-num=14
en-affil=Japan Synchrotron Radiation Research Institute
kn-affil=

affil-num=15
en-affil=Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Mechanical Engineering, Osaka Institute of Technology
kn-affil=

affil-num=17
en-affil=Graduate School of Organic Materials Engineering, Yamagata University
kn-affil=

affil-num=18
en-affil=Department of Macromolecular Science, Graduate School of Science and Forefront Research Center for Fundamental Sciences, Osaka University
kn-affil=
en-keyword=stress-strain sensor
kn-keyword=stress-strain sensor
en-keyword=carbon composite
kn-keyword=carbon composite
en-keyword=movable cross-link
kn-keyword=movable cross-link
en-keyword=supramolecular materials
kn-keyword=supramolecular materials
en-keyword=polymericmaterials
kn-keyword=polymericmaterials
en-keyword=tough materials
kn-keyword=tough materials
en-keyword=upcycling
kn-keyword=upcycling
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=4
article-no=
start-page=439
end-page=442
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Boy Safely Treated with Tyrosine Kinase Inhibitors for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Osteolysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A three-year-old boy with Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ALL) presented with an osteolytic lesion in his right upper arm. Tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib are an essential component throughout the course of treatment for Ph+ALL. However, TKIs are reported to affect the bone metabolism. In the treatment course of the current patient, the osteolytic lesion quickly improved despite the continuous use of TKIs, even during the concomitant use of corticosteroids. This suggests that TKIs can be safely given with concomitant corticosteroids to children with Ph+ALL, even when osteolytic lesions are present.
en-copyright=
kn-copyright=

en-aut-name=ShiwakuTakahiro
en-aut-sei=Shiwaku
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshidaHisashi
en-aut-sei=Ishida
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TatebeYasuhisa
en-aut-sei=Tatebe
en-aut-mei=Yasuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TamefusaKosuke
en-aut-sei=Tamefusa
en-aut-mei=Kosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OchiMotoharu
en-aut-sei=Ochi
en-aut-mei=Motoharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FujiwaraKaori
en-aut-sei=Fujiwara
en-aut-mei=Kaori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KuboToshihide
en-aut-sei=Kubo
en-aut-mei=Toshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=WashioKana
en-aut-sei=Washio
en-aut-mei=Kana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TsukaharaHirokazu
en-aut-sei=Tsukahara
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Pediatrics, National Hospital Organization Okayama Medical Center
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=
en-keyword=acute lymphoblastic leukemia
kn-keyword=acute lymphoblastic leukemia
en-keyword=children
kn-keyword=children
en-keyword=tyrosine kinase inhibitor
kn-keyword=tyrosine kinase inhibitor
en-keyword=osteolysis
kn-keyword=osteolysis
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=4
article-no=
start-page=359
end-page=364
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Changes in TRPV1 Receptor, CGRP, and BDNF Expression in Rat Dorsal Root Ganglion with Resiniferatoxin-Induced Neuropathic Pain: Modulation by Pulsed Radiofrequency Applied to the Sciatic Nerve
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia.
en-copyright=
kn-copyright=

en-aut-name=KoshidaTomohiro
en-aut-sei=Koshida
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MarutaToyoaki
en-aut-sei=Maruta
en-aut-mei=Toyoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaNobuhiko
en-aut-sei=Tanaka
en-aut-mei=Nobuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HidakaKotaro
en-aut-sei=Hidaka
en-aut-mei=Kotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KurogiMio
en-aut-sei=Kurogi
en-aut-mei=Mio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NemotoTakayuki
en-aut-sei=Nemoto
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YanagitaToshihiko
en-aut-sei=Yanagita
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakeyaRyu
en-aut-sei=Takeya
en-aut-mei=Ryu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TsuneyoshiIsao
en-aut-sei=Tsuneyoshi
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Pain Clinic, Faculty of Medicine, University of Miyazaki
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Pain Clinic, Faculty of Medicine, University of Miyazaki
kn-affil=

affil-num=3
en-affil=Tanaka homecare clinic
kn-affil=

affil-num=4
en-affil=Department of Anesthesiology and Pain Clinic, Faculty of Medicine, University of Miyazaki
kn-affil=

affil-num=5
en-affil=Department of Anesthesiology and Pain Clinic, Faculty of Medicine, University of Miyazaki
kn-affil=

affil-num=6
en-affil=Department of Pharmacology, Faculty of Medicine, Fukuoka University
kn-affil=

affil-num=7
en-affil=Department of Clinical Pharmacology, School of Nursing, Faculty of Medicine, University of Miyazaki
kn-affil=

affil-num=8
en-affil=Department of Pharmacology, Faculty of Medicine, University of Miyazaki
kn-affil=

affil-num=9
en-affil=Department of Anesthesiology and Pain Clinic, Faculty of Medicine, University of Miyazaki
kn-affil=
en-keyword=pulsed radiofrequency
kn-keyword=pulsed radiofrequency
en-keyword=resiniferatoxin
kn-keyword=resiniferatoxin
en-keyword=transient receptor potential vanilloid subtype-1 (TRPV1)
kn-keyword=transient receptor potential vanilloid subtype-1 (TRPV1)
en-keyword=calcitonin gene-related peptide (CGRP)
kn-keyword=calcitonin gene-related peptide (CGRP)
en-keyword=brain-derived neurotrophic factor (BDNF)
kn-keyword=brain-derived neurotrophic factor (BDNF)
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=3
article-no=
start-page=323
end-page=330
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Utility of Comprehensive Genomic Profiling for Precise Diagnosis of Pediatric-Type Diffuse High-Grade Glioma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases.
en-copyright=
kn-copyright=

en-aut-name=MakinoKeigo
en-aut-sei=Makino
en-aut-mei=Keigo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OtaniYoshihiro
en-aut-sei=Otani
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiiKentaro
en-aut-sei=Fujii
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshidaJoji
en-aut-sei=Ishida
en-aut-mei=Joji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HiranoShuichiro 
en-aut-sei=Hirano
en-aut-mei=Shuichiro 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SurugaYasuki
en-aut-sei=Suruga
en-aut-mei=Yasuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=WashioKana
en-aut-sei=Washio
en-aut-mei=Kana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NishidaKenji
en-aut-sei=Nishida
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YanaiHiroyuki
en-aut-sei=Yanai
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TomidaShuta
en-aut-sei=Tomida
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=EnnishiDaisuke
en-aut-sei=Ennishi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Departments of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Departments of Pathology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Departments of Pathology, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=comprehensive genomic profiling
kn-keyword=comprehensive genomic profiling
en-keyword=pediatric brain tumor
kn-keyword=pediatric brain tumor
en-keyword=genome-wide DNA methylation
kn-keyword=genome-wide DNA methylation
en-keyword=MYCN
kn-keyword=MYCN
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=3
article-no=
start-page=301
end-page=309
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Associations between Comorbidities and Acute Exacerbation of Interstitial Lung Disease after Primary Lung Cancer Surgery
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Acute exacerbation (AE) of interstitial lung disease (ILD) is a severe complication of lung resection in lung cancer patients with ILD (LC-ILD). This study aimed to assess the predictive value of comorbidities other than ILD for postoperative AE in patients with LC-ILD. We retrospectively evaluated 68 patients with LC-ILD who had undergone lung resection. We classified them into two groups: those who had developed postoperative AE within 30 days after resection and those who had not. We analyzed patient characteristics, high-resolution computed tomography findings, clinical data, pulmonary function, and intraoperative data. The incidence of postoperative AEs was 11.8%. In univariate analysis, performance status (PS), honeycombing, forced vital capacity (FVC), and high hemoglobin A1c (HbA1c) levels without comorbidities were significantly associated with postoperative AE. Patients were divided into two groups according to cutoff levels of those four variables as determined by receiver operating characteristic curves, revealing that the rates of patients without postoperative AE differed significantly between groups. The present results suggested that preoperative comorbidities other than ILD were not risk factors for postoperative AE in patients with LC-ILD. However, a high preoperative HbA1c level, poor PS, low FVC, and honeycombing may be associated with postoperative AE of LC-ILD.
en-copyright=
kn-copyright=

en-aut-name=KatoTakahide
en-aut-sei=Kato
en-aut-mei=Takahide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyoshiSeigo
en-aut-sei=Miyoshi
en-aut-mei=Seigo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HamadaChizuru
en-aut-sei=Hamada
en-aut-mei=Chizuru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SanoYoshifumi
en-aut-sei=Sano
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NogamiNaoyuki
en-aut-sei=Nogami
en-aut-mei=Naoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamaguchiOsamu
en-aut-sei=Yamaguchi
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HamaguchiNaohiko
en-aut-sei=Hamaguchi
en-aut-mei=Naohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Community Medicine, Pulmonology and Cardiology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=
en-keyword=lung cancer
kn-keyword=lung cancer
en-keyword=interstitial lung disease
kn-keyword=interstitial lung disease
en-keyword=acute exacerbation
kn-keyword=acute exacerbation
en-keyword=comorbidity
kn-keyword=comorbidity
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=3
article-no=
start-page=263
end-page=272
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Early Fluid Balance Is Associated with 90-Day Mortality in Patients Receiving Continuous Renal Replacement Therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Continuous renal replacement therapy (CRRT) is widely used to control fluid balance, but the optimal fluid balance to improve the prognosis of patients remains debated. Appropriate fluid management may depend on hemodynamic status. We investigated the association between 90-day mortality and fluid balance/mean arterial pressure (MAP) in patients receiving CRRT. This single-center retrospective study was conducted between May 2018 and March 2021. Based on the cumulative fluid balance at 72 h after initiation of CRRT, the cases were divided into negative (< 0 mL) and positive (> 0 mL) fluid balance groups. Ninety-day mortality was higher in the positive fluid balance group (p=0.009). At 4 h before and after CRRT initiation, the mean MAP was lower in the positive fluid balance group (p<0.05). After multivariate cox adjustment, 72-h positive fluid balance was independently associated with 90-day mortality (p=0.004). In addition, the cumulative fluid balance was associated with 90-day mortality (p<0.05) in cases without shock, high APACHE II score, sepsis, dialysis dependence, or vasopressor use. A 72-h positive fluid balance was associated with 90-day mortality in patients receiving CRRT.
en-copyright=
kn-copyright=

en-aut-name=GuoYusheng
en-aut-sei=Guo
en-aut-mei=Yusheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KosakaJunko
en-aut-sei=Kosaka
en-aut-mei=Junko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=fluid management
kn-keyword=fluid management
en-keyword=continuous renal replacement therapy
kn-keyword=continuous renal replacement therapy
en-keyword=mortality
kn-keyword=mortality
en-keyword=mean arterial pressure
kn-keyword=mean arterial pressure
en-keyword=daily cumulative fluid balance
kn-keyword=daily cumulative fluid balance
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=2
article-no=
start-page=161
end-page=167
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Prolonged Double-Low Time and the Incidence of Postoperative Delirium in Surgical ICU Patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An intraoperative double-low condition is defined as concurrent low values for bispectral index (BIS) and mean arterial pressure (MAP), and may predict perioperative outcomes. We hypothesized that prolonged double-low times might be associated with an increased incidence of postoperative delirium. We conducted a single-center retrospective observational study on patients who had been admitted to our hospital’s intensive care unit (ICU) after surgery and whose BIS and MAP data had been recorded during general anesthesia. The primary outcome was the incidence of postoperative delirium. A double-low condition was defined as BIS < 45 and MAP <75 mmHg. The total double-low time was calculated in 1-min increments and used to divide the patients into quintiles. Multiple logistic regression analyses were conducted. Among the 334 patients included in the study, the incidence of postoperative delirium was 15.6% (n=52). Multiple logistic regression analysis revealed that a prolonged double-low time, defined as a total double-low time of > 42 min (i.e., third, fourth, and fifth quintiles), was significantly associated with an increased incidence of postoperative delirium (adjusted odds ratio: 2.61, 95% confidence interval: 1.27-5.37, p=0.009). Prolonged double-low time during general anesthesia was independently associated with an increased incidence of postoperative delirium in surgical ICU patients.
en-copyright=
kn-copyright=

en-aut-name=YamanoiTomoko
en-aut-sei=Yamanoi
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SuzukiSatoshi
en-aut-sei=Suzuki
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KakuRyuji
en-aut-sei=Kaku
en-aut-mei=Ryuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Intensive Care Medicine, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Anesthesiology, Mie University Hospital
kn-affil=

affil-num=4
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=postoperative delirium
kn-keyword=postoperative delirium
en-keyword=bispectral index
kn-keyword=bispectral index
en-keyword=hypotension
kn-keyword=hypotension
en-keyword=double-low condition
kn-keyword=double-low condition
en-keyword=general anesthesia
kn-keyword=general anesthesia
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=50
article-no=
start-page=e32424
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221216
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Safety and efficacy of capsule endoscopy for patients with newly diagnosed Crohn's disease: A multicenter retrospective study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Crohn's disease (CD) is a chronic inflammatory disease that develops at a young age and frequently leads to intestinal resection. Capsule endoscopy (CE) can directly and non-invasively inspect the entire small bowel mucosa. We suspected that CE could be a good diagnostic tool for detecting CD in young patients. The aim of this study was to investigate the safety and efficacy of CE in patients with newly diagnosed CD and to evaluate the CE findings, especially in the upper small bowel of young patients. We retrospectively investigated 32 patients with newly diagnosed CD from 5 institutions. Patient characteristics, clinical course, and characteristics of CE findings were analyzed. The total small intestine observation rate was 93%, and the retention rate was 3% (1/32). No abnormality was identified by ileocolonoscopy in 46% (15/32), and transition of small bowel lesions (TSL) was found in 35% (12/34) of the patients. The frequency of longitudinal ulcers and cobblestones in the upper small intestine was significantly higher in younger patients (<= 20 years). Moreover, positive findings in the upper small intestine were predominantly observed in younger patients (<= 20 years). CE for patients with newly diagnosed CD was safe and useful, especially for the detection of upper small bowel lesions in young patients.
en-copyright=
kn-copyright=

en-aut-name=KawanoSeiji
en-aut-sei=Kawano
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkaShiro
en-aut-sei=Oka
en-aut-mei=Shiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShiotaniAkiko
en-aut-sei=Shiotani
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HashimotoShinichi
en-aut-sei=Hashimoto
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakahashiSakuma
en-aut-sei=Takahashi
en-aut-mei=Sakuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HandaOsamu
en-aut-sei=Handa
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakamiTaro
en-aut-sei=Takami
en-aut-mei=Taro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=InabaTomoki
en-aut-sei=Inaba
en-aut-mei=Tomoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TanakaShinji
en-aut-sei=Tanaka
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Metabolism, Hiroshima University Hospital
kn-affil=

affil-num=3
en-affil=Department of Internal Medicine, Division of Gastroenterology,  Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and  Hepatology, Yamaguchi University Graduate School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=6
en-affil=Department of Internal Medicine, Division of Gastroenterology,  Kawasaki Medical School
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and  Hepatology, Yamaguchi University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate  School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Metabolism, Hiroshima University Hospital
kn-affil=
en-keyword=capsule endoscopy
kn-keyword=capsule endoscopy
en-keyword=Crohn's disease
kn-keyword=Crohn's disease
en-keyword=upper small intestine
kn-keyword=upper small intestine
en-keyword=young patients
kn-keyword=young patients
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=755
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Metformin and Its Immune-Mediated Effects in Various Diseases
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Metformin has been a long-standing prescribed drug for treatment of type 2 diabetes (T2D) and its beneficial effects on virus infection, autoimmune diseases, aging and cancers are also recognized. Metformin modulates the differentiation and activation of various immune-mediated cells such as CD4+ and CD+8 T cells. The activation of adenosine 5 '-monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin complex 1 (mTORC1) pathway may be involved in this process. Recent studies using Extracellular Flux Analyzer demonstrated that metformin alters the activities of glycolysis, oxidative phosphorylation (OXPHOS), lipid oxidation, and glutaminolysis, which tightly link to the modulation of cytokine production in CD4+ and CD+8 T cells in various disease states, such as virus infection, autoimmune diseases, aging and cancers.
en-copyright=
kn-copyright=

en-aut-name=NojimaIchiro
en-aut-sei=Nojima
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=CD8 T cells
kn-keyword=CD8 T cells
en-keyword=AMPK
kn-keyword=AMPK
en-keyword=mTORC
kn-keyword=mTORC
en-keyword=OXPHOS
kn-keyword=OXPHOS
en-keyword=autoimmune disease
kn-keyword=autoimmune disease
en-keyword=aging
kn-keyword=aging
en-keyword=cancer
kn-keyword=cancer
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=6
article-no=
start-page=749
end-page=754
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Salvage Surgery for Symptomatic Recurrence of Retro-Odontoid Pseudotumor after a C1 Laminectomy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We provide the first report of successful salvage surgery for a post-C1 laminectomy symptomatic recurrence of a retro-odontoid pseudotumor (ROP) that caused myelopathy. The 72-year-old Japanese woman presented with an ROP causing symptomatic cervical myelopathy. With ultrasonography support, we performed the enucleation of the ROP via a transdural approach and fusion surgery for the recurrence of the mass. At the final observation 2-year post-surgery, MRI demonstrated the mass’s regression and spinal cord decompression, and the patient’s symptoms had improved. Our strategy is an effective option for a symptomatic recurrence of ROP.
en-copyright=
kn-copyright=

en-aut-name=TakamiMasanari
en-aut-sei=Takami
en-aut-mei=Masanari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YukawaYasutsugu
en-aut-sei=Yukawa
en-aut-mei=Yasutsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NodaYusuke
en-aut-sei=Noda
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YoshidaMunehito
en-aut-sei=Yoshida
en-aut-mei=Munehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamadaHiroshi
en-aut-sei=Yamada
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Wakayama Medical University
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Wakayama Medical University
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Wakayama Rosai Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Wakayama Medical University
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Wakayama Medical University
kn-affil=
en-keyword=recurrent retro-odontoid pseudotumor
kn-keyword=recurrent retro-odontoid pseudotumor
en-keyword=salvage surgery
kn-keyword=salvage surgery
en-keyword=transdural resection
kn-keyword=transdural resection
en-keyword=C1 laminectomy
kn-keyword=C1 laminectomy
en-keyword=ultra-sonography
kn-keyword=ultra-sonography
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=6
article-no=
start-page=737
end-page=742
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Case of Paraplegia Treated with Cerebrospinal Fluid Drainage and Permissive Hypertension after Graft Replacement of the Ascending Aorta and the Total Aortic Arch for Acute Aortic Dissection Stanford Type A
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Paraplegia after an operation for acute aortic dissection Stanford type A (AADA) is fairly uncommon, and there is no consensus about optimal treatment. We present a case in which cerebrospinal fluid drainage (CSFD) and permissive hypertension were used for treatment of paraplegia. When the patient showed complete bilateral paraplegia after operation for AADA, we immediately began CSFD and maintained mean arterial blood pressure at over 90 mmHg. His neurological deficit gradually recovered, and he was eventually able to walk without support. The combination of CSFD and permissive hypertension could be a first-line emergent treatment for postoperative paraplegia after AADA surgery.
en-copyright=
kn-copyright=

en-aut-name=YamaokaMasakazu
en-aut-sei=Yamaoka
en-aut-mei=Masakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoYumi
en-aut-sei=Yamamoto
en-aut-mei=Yumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MinamiEriko
en-aut-sei=Minami
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Anesthesiology, Japanese Red Cross Society Himeji Hospital
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Critical Care Medicine, Hiroshima Citizens Hospital
kn-affil=

affil-num=3
en-affil=Department of Anesthesiology, Japanese Red Cross Society Himeji Hospital
kn-affil=
en-keyword=paraplegia
kn-keyword=paraplegia
en-keyword=acute aortic dissection
kn-keyword=acute aortic dissection
en-keyword=cerebrospinal drainage
kn-keyword=cerebrospinal drainage
en-keyword=permissive hypertension
kn-keyword=permissive hypertension
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=6
article-no=
start-page=695
end-page=703
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=History of Transcatheter Arterial Chemoembolization Predicts the Efficacy of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC.
en-copyright=
kn-copyright=

en-aut-name=OnishiHideki
en-aut-sei=Onishi
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NousoKazuhiro
en-aut-sei=Nouso
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakakiAkinobu
en-aut-sei=Takaki
en-aut-mei=Akinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OyamaAtsushi
en-aut-sei=Oyama
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AdachiTakuya
en-aut-sei=Adachi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=WadaNozomu
en-aut-sei=Wada
en-aut-mei=Nozomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakeuchiYasuto
en-aut-sei=Takeuchi
en-aut-mei=Yasuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShirahaHidenori
en-aut-sei=Shiraha
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=hepatic arterial infusion chemotherapy
kn-keyword=hepatic arterial infusion chemotherapy
en-keyword=hepatocellular carcinoma
kn-keyword=hepatocellular carcinoma
en-keyword=refractory
kn-keyword=refractory
en-keyword=transcatheter arterial chemoembolization
kn-keyword=transcatheter arterial chemoembolization
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=593
end-page=596
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=COVID-19 Vaccine-Associated Lymphadenopathy Mimicking Regrowth of Axillary Lymph Node Metastasis of Lung Adenocarcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We encountered a woman with re-enlarged axillary lymph nodes during a computed tomography (CT) scan for surveillance of lung adenocarcinoma with axillary lymph node metastasis at the initial diagnosis that had shrunk with standard chemotherapy. We first suspected cancer recurrence and considered a change in the chemotherapeutic regimen. However, after careful history taking regarding the timing of her Coronavirus Disease 2019 (COVID-19) vaccination, and subsequent careful, close follow-up, radiological shrinkage suggested a strictly benign cause. Especially in lung cancer with a medical history of axillary lymph node involvement, cliniciansshould be aware that vaccine-associated lymphadenopathy can mimic cancer recurrence and sometimesprompt serious misjudgment regarding a current treatment course and strategy.
en-copyright=
kn-copyright=

en-aut-name=NoumiTaku
en-aut-sei=Noumi
en-aut-mei=Taku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeHiromi
en-aut-sei=Watanabe
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NinomiyaKiichiro
en-aut-sei=Ninomiya
en-aut-mei=Kiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OhashiKadoaki
en-aut-sei=Ohashi
en-aut-mei=Kadoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IchiharaEiki
en-aut-sei=Ichihara
en-aut-mei=Eiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KuboToshio
en-aut-sei=Kubo
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MakimotoGo
en-aut-sei=Makimoto
en-aut-mei=Go
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KatoYuka
en-aut-sei=Kato
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=FujiiMasanori
en-aut-sei=Fujii
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TabataMasahiro
en-aut-sei=Tabata
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HottaKatsuyuki
en-aut-sei=Hotta
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=
en-keyword=lung cancer
kn-keyword=lung cancer
en-keyword=COVID-19 vaccination
kn-keyword=COVID-19 vaccination
en-keyword=axillary lymphadenopathy
kn-keyword=axillary lymphadenopathy
en-keyword=case report
kn-keyword=case report
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=557
end-page=564
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Correlation between Mean Arterial Pressure and Regional Cerebral Oxygen Saturation on Cardiopulmonary Bypass in Pediatric Cardiac Surgery
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Some pediatric cardiac patients might experience low regional cerebral oxygen saturation (rSO2) during surgery. We investigated whether a pediatric patient’s mean arterial pressure (MAP) can affect the rSO2 value during cardiopulmonary bypass (CPB). We retrospectively analyzed the cases of the pediatric patients who underwentcardiac surgery at our hospital (Jan. –Dec. 2019; n=141). At each MAP stage, we constructed line charts through the mean of the rSO2 values corresponding to each MAP and then calculated the correlation coefficients. We next divided the patients into age subgroups (neonates, infants, children) and into cyanotic congenital heart disease (CHD) and acyanotic CHD groups and analyzed these groups in the same way. The analyses of all 141 patients revealed that during CPB the rSO2 value increased with an increase in MAP (r=0.1626). There was a correlation between rSO2 and MAP in the children (r=0.2720) but not in the neonates (r=0.06626) or infants (r=0.05260). Cyanotic CHD or acyanotic CHD did not have a significant effect on the rSO2/MAP correlation. Our analysis demonstrated different patterns of a correlation between MAP and rSO2 in pediatric cardiac surgery patients, depending on age. MAP was positively correlated with rSO2 typically in children but not in neonate or infant patients.
en-copyright=
kn-copyright=

en-aut-name=PanYu
en-aut-sei=Pan
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SongQingqing
en-aut-sei=Song
en-aut-mei=Qingqing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KanazawaTomoyuki
en-aut-sei=Kanazawa
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=mean arterial pressure
kn-keyword=mean arterial pressure
en-keyword=cerebral oxygen saturation
kn-keyword=cerebral oxygen saturation
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=511
end-page=517
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Model-Based Iterative Reconstruction in Low-Dose Paranasal Computed Tomography: A Comparison with Filtered Back Projection and Hybrid Iterative Reconstruction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Iterative reconstruction (IR) improves image quality compared with filtered back projection (FBP). This study investigated the usefulness of model-based IR (forward-projected model-based iterative reconstruction solution [FIRST]) in comparison with FBP and hybrid IR (adaptive iterative dose reduction three-dimensional processing [AIDR 3D]) in low-dose paranasal CT. Twenty-four patients with paranasal sinusitis who underwent standard-dose CT (120 kV) and low-dose CT (100 kV) scanning before and after medical treatment were enrolled. Standard-dose CT scans were reconstructed with FBP (FBP120), and low-dose CT scans with FBP (FBP100), AIDR 3D, and FIRST. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in three anatomical 
structures and effective doses were compared using Mann–Whitney U test. Two radiologists independently evaluated the visibility of 16 anatomical structures, overall image quality, and artifacts. Effective doses in lowdose CT were significantly reduced compared with those in standard-dose CT (0.24 vs 0.43 mSv, p<0.001).  FIRST achieved significantly higher SNR (p<0.01, respectively) and CNR (p<0.001, respectively) of evaluated structures and significant improvement in overall image quality (p<0.001), artifacts (p<0.001), and visibility related to muscles (p<0.05) compared to FBP120, FBP100, and AIDR 3D. FIRST allowed radiation-dose reduction, while maintaining objective and subjective image quality in low-dose paranasal CT.
en-copyright=
kn-copyright=

en-aut-name=TomitaHayato
en-aut-sei=Tomita
en-aut-mei=Hayato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KuramochiKenji
en-aut-sei=Kuramochi
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujikawaAtsuko
en-aut-sei=Fujikawa
en-aut-mei=Atsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IkedaHirotaka
en-aut-sei=Ikeda
en-aut-mei=Hirotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KomitaMidori
en-aut-sei=Komita
en-aut-mei=Midori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KuriharaYoshiko
en-aut-sei=Kurihara
en-aut-mei=Yoshiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KobayashiYasuyuki
en-aut-sei=Kobayashi
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MimuraHidefumi
en-aut-sei=Mimura
en-aut-mei=Hidefumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Radiology, St. Marianna University School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Radiology, St. Marianna University School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Radiology, St. Marianna University School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Radiology, Fujita Health University School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Radiology, St. Marianna University School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Radiology, Machida Municipal Hospital
kn-affil=

affil-num=7
en-affil=Department of Advanced Biomedical Imaging Informatics, St. Marianna University School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Radiology, St. Marianna University School of Medicine
kn-affil=
en-keyword=paranasal sinuses
kn-keyword=paranasal sinuses
en-keyword=iterative reconstruction
kn-keyword=iterative reconstruction
en-keyword=dose reduction
kn-keyword=dose reduction
en-keyword=low dose
kn-keyword=low dose
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=503
end-page=510
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Viral Sequences Are Repurposed for Controlling Antiviral Responses as Non-Retroviral Endogenous Viral Elements
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches.
en-copyright=
kn-copyright=

en-aut-name=OgawaHirohito
en-aut-sei=Ogawa
en-aut-mei=Hirohito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HondaTomoyuki
en-aut-sei=Honda
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Virology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Virology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=EVE
kn-keyword=EVE
en-keyword=nrEVE
kn-keyword=nrEVE
en-keyword=bornavirus
kn-keyword=bornavirus
en-keyword=filovirus
kn-keyword=filovirus
en-keyword=antiviral
kn-keyword=antiviral
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=489
end-page=502
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Current Insights into Mesenchymal Signatures in Glioblastoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoYuji
en-aut-sei=Matsumoto
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IchikawaTomotsugu
en-aut-sei=Ichikawa
en-aut-mei=Tomotsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KurozumiKazuhiko
en-aut-sei=Kurozumi
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neurological Surgery, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=3
en-affil=Department of Neurosurgery, Hamamatsu University Hospital
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=glioma
kn-keyword=glioma
en-keyword=glioblastoma
kn-keyword=glioblastoma
en-keyword=mesenchymal subtype
kn-keyword=mesenchymal subtype
en-keyword=mesenchymal transition
kn-keyword=mesenchymal transition
en-keyword=heterogeneity
kn-keyword=heterogeneity
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=4
article-no=
start-page=429
end-page=437
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Association between Preoperative Blood Pressure Elevations and Postoperative Adverse Outcomes after Non-cardiac Surgery: A Single-center Retrospective Observational Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Blood pressure (BP) often rises before surgery. This study investigated whether BP elevation immediately before surgery was associated with adverse outcomes. Medical records of 11,732 patients (average age: 61 years; male: 47.4%) who underwent non-cardiac elective inpatient surgery under general anesthesia at Kagawa University Hospital between January 2011 and June 2019 were reviewed. Differences between the first BP values measured on the day before surgery and the first BP values in the operating room were defined as Δ systolic BP (ΔSBP) and Δ diastolic BP (ΔDBP). The relationships between ΔSBP/ΔDBP and 30-day mortality, 30-day readmission, and over-the-standard length of hospital stay (OSLOS) were assessed. OSLOS was defined as a hospital stay longer than mean+2 standard deviations and was calculated using the Japanese Diagnosis Procedure Combination data. In univariate analysis, the differences in ΔSBP and ΔDBP between the OSLOS and standard LOS groups were both 2 mmHg. In multivariate logistic regression analysis, only ΔDBP was associated with OSLOS. The adjusted odds ratio (95% confidence interval) for the largest quartile was 1.31 (1.02-1.69) (p<0.05). ΔDBP was associated with OSLOS; however, there may be little need to worry about large ΔSBPs and ΔDBPs in clinical practice.
en-copyright=
kn-copyright=

en-aut-name=YamadoriYusuke
en-aut-sei=Yamadori
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HiraoTomohiro
en-aut-sei=Hirao
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Nlandu R. Ngatu
en-aut-sei=Nlandu R. Ngatu
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KandaKanae
en-aut-sei=Kanda
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=Syed Mahfuz Al Hasan
en-aut-sei=Syed Mahfuz Al Hasan
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurakamiAkitsu
en-aut-sei=Murakami
en-aut-mei=Akitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MashimaYukinori
en-aut-sei=Mashima
en-aut-mei=Yukinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShirakamiGotaro
en-aut-sei=Shirakami
en-aut-mei=Gotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Anesthesiology,  Faculty of Medicine, Kagawa University
kn-affil=

affil-num=2
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=3
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=4
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=5
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=6
en-affil=Department of Anesthesiology,  Faculty of Medicine, Kagawa University
kn-affil=

affil-num=7
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=8
en-affil=Department of Anesthesiology,  Faculty of Medicine, Kagawa University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=3
article-no=
start-page=291
end-page=295
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Factors Associated with Surgical Field Bacterial Detection during Total Hip Arthroplasty
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (± 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ≥ 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure.
en-copyright=
kn-copyright=

en-aut-name=MiyakeYoshiaki
en-aut-sei=Miyake
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MitaniShigeru
en-aut-sei=Mitani
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NambaYoshifumi
en-aut-sei=Namba
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UmeharaNorifumi
en-aut-sei=Umehara
en-aut-mei=Norifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawamotoToyohiro
en-aut-sei=Kawamoto
en-aut-mei=Toyohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FuruichiShuro
en-aut-sei=Furuichi
en-aut-mei=Shuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=

affil-num=2
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=

affil-num=3
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=
en-keyword=total hip arthroplasty
kn-keyword=total hip arthroplasty
en-keyword=bacterial contamination
kn-keyword=bacterial contamination
en-keyword=periprosthetic joint infection
kn-keyword=periprosthetic joint infection
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=3
article-no=
start-page=281
end-page=290
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histone Demethylase Jmjd3 Regulates the Osteogenic Differentiation and Cytokine Expressions of Periodontal Ligament Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions.
en-copyright=
kn-copyright=

en-aut-name=YuBo
en-aut-sei=Yu
en-aut-mei=Bo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WangRui
en-aut-sei=Wang
en-aut-mei=Rui
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=LuoHuikun
en-aut-sei=Luo
en-aut-mei=Huikun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YangDi
en-aut-sei=Yang
en-aut-mei=Di
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WangSimo
en-aut-sei=Wang
en-aut-mei=Simo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YuYaqiong
en-aut-sei=Yu
en-aut-mei=Yaqiong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkamuraHirohiko
en-aut-sei=Okamura
en-aut-mei=Hirohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=QiuLihong
en-aut-sei=Qiu
en-aut-mei=Lihong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease
kn-affil=

affil-num=2
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease
kn-affil=

affil-num=3
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease
kn-affil=

affil-num=4
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease
kn-affil=

affil-num=5
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease
kn-affil=

affil-num=6
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease
kn-affil=

affil-num=7
en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Endodontics, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Disease
kn-affil=
en-keyword=periapical lesions
kn-keyword=periapical lesions
en-keyword=histone demethylase Jmjd3
kn-keyword=histone demethylase Jmjd3
en-keyword=periodontal ligament cell
kn-keyword=periodontal ligament cell
en-keyword=osteogenic differentiation
kn-keyword=osteogenic differentiation
en-keyword=proinflammatory cytokines
kn-keyword=proinflammatory cytokines
END

start-ver=1.4
cd-journal=joma
no-vol=63
cd-vols=
no-issue=5
article-no=
start-page=713
end-page=728
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=2022321
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sorghum Ionomics Reveals the Functional SbHMA3a Allele that Limits Excess Cadmium Accumulation in Grains
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Understanding uptake and redistribution of essential minerals or sequestering of toxic elements is important for optimized crop production. Although the mechanisms controlling mineral transport have been elucidated in rice and other species, little is understood in sorghum—an important C4 cereal crop. Here, we assessed the genetic factors that govern grain ionome profiles in sorghum using recombinant inbred lines (RILs) derived from a cross between BTx623 and NOG (Takakibi). Pairwise correlation and clustering analysis of 22 elements, measured in sorghum grains harvested under greenhouse conditions, indicated that the parental lines, as well as the RILs, show different ionomes. In particular, BTx623 accumulated significantly higher levels of cadmium (Cd) than NOG, because of differential root-to-shoot translocation factors between the two lines. Quantitative trait locus (QTL) analysis revealed a prominent QTL for grain Cd concentration on chromosome 2. Detailed analysis identified SbHMA3a, encoding a P1B-type ATPase heavy metal transporter, as responsible for low Cd accumulation in grains; the NOG allele encoded a functional HMA3 transporter (SbHMA3a-NOG) whose Cd-transporting activity was confirmed by heterologous expression in yeast. BTx623 possessed a truncated, loss-of-function SbHMA3a allele. The functionality of SbHMA3a in NOG was confirmed by Cd concentrations of F2 grains derived from the reciprocal cross, in which the NOG allele behaved in a dominant manner. We concluded that SbHMA3a-NOG is a Cd transporter that sequesters excess Cd in root tissues, as shown in other HMA3s. Our findings will facilitate the isolation of breeding cultivars with low Cd in grains or in exploiting high-Cd cultivars for phytoremediation.
en-copyright=
kn-copyright=

en-aut-name=WahinyaFiona Wacera
en-aut-sei=Wahinya
en-aut-mei=Fiona Wacera
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamazakiKiyoshi
en-aut-sei=Yamazaki
en-aut-mei=Kiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=JingZihuan
en-aut-sei=Jing
en-aut-mei=Zihuan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakamiTsuneaki
en-aut-sei=Takami
en-aut-mei=Tsuneaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamiyaTakehiro
en-aut-sei=Kamiya
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Kajiya-KanegaeHiromi
en-aut-sei=Kajiya-Kanegae
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakanashiHideki
en-aut-sei=Takanashi
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IwataHiroyoshi
en-aut-sei=Iwata
en-aut-mei=Hiroyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TsutsumiNobuhiro
en-aut-sei=Tsutsumi
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=FujiwaraToru
en-aut-sei=Fujiwara
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SakamotoWataru
en-aut-sei=Sakamoto
en-aut-mei=Wataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University,
kn-affil=

affil-num=2
en-affil=Graduate School of Agricultural and Life Sciences, The University of Tokyo
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Agricultural and Life Sciences, The University of Tokyo
kn-affil=

affil-num=6
en-affil=Research Center for Agricultural Information Technology, National Agriculture and Food Research Organization
kn-affil=

affil-num=7
en-affil=Graduate School of Agricultural and Life Sciences, The University of Tokyo
kn-affil=

affil-num=8
en-affil=Graduate School of Agricultural and Life Sciences, The University of Tokyo
kn-affil=

affil-num=9
en-affil=Graduate School of Agricultural and Life Sciences, The University of Tokyo
kn-affil=

affil-num=10
en-affil=Graduate School of Agricultural and Life Sciences, The University of Tokyo
kn-affil=

affil-num=11
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=2
article-no=
start-page=229
end-page=233
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Case of Primary Osteosarcoma of the Mandible That Responded to Preoperative Chemotherapy: p16 as a Potential Prognostic Factor
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy.
en-copyright=
kn-copyright=

en-aut-name=KonoTakashi
en-aut-sei=Kono
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MondenNobuya
en-aut-sei=Monden
en-aut-mei=Nobuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ChikuieNobuyuki
en-aut-sei=Chikuie
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TaruyaTakayuki
en-aut-sei=Taruya
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HamamotoTakao
en-aut-sei=Hamamoto
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshinoTakashi
en-aut-sei=Ishino
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=UedaTsutomu
en-aut-sei=Ueda
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakenoSachio
en-aut-sei=Takeno
en-aut-mei=Sachio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=2
en-affil=Division of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=3
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=4
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=5
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=6
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=7
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=8
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=
en-keyword=head and neck osteosarcomas
kn-keyword=head and neck osteosarcomas
en-keyword=tumor suppressor p16
kn-keyword=tumor suppressor p16
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=2
article-no=
start-page=217
end-page=223
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Pediatric Case of Cauda Equina Dermoid Cyst Resected by Minimally Invasive Unilateral Hemilaminectomy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery.
en-copyright=
kn-copyright=

en-aut-name=YabunoSatoru
en-aut-sei=Yabuno
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SasadaSusumu
en-aut-sei=Sasada
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UmakoshiMichiari
en-aut-sei=Umakoshi
en-aut-mei=Michiari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NagaseTakayuki
en-aut-sei=Nagase
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SugaharaChiaki
en-aut-sei=Sugahara
en-aut-mei=Chiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KawauchiSatoshi
en-aut-sei=Kawauchi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YasuharaTakao
en-aut-sei=Yasuhara
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Neurosurgery, Kagawa Rosai Hospital
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=cauda equina tumor
kn-keyword=cauda equina tumor
en-keyword=child
kn-keyword=child
en-keyword=dermoid cyst
kn-keyword=dermoid cyst
en-keyword=hemilaminectomy
kn-keyword=hemilaminectomy
en-keyword=spinal tumor
kn-keyword=spinal tumor
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=2
article-no=
start-page=195
end-page=202
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Safety and Effectiveness of Perospirone in Comparison to Risperidone for Treatment of Delirium in Patients with Advanced Cancer: A Multicenter Prospective Observational Study in Real-World Psycho-Oncology Settings
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The clinical benefit of perospirone for treatment of delirium in patients with advanced cancer is not sufficiently clear. The objective of this study was to compare the safety and effectiveness of perospirone to those of risperidone for the treatment of delirium in patients with advanced cancer. This is a secondary analysis of a multicenter prospective observational study in nine psycho-oncology consultation services in Japan. The study used the Delirium Rating Scale (DRS) Revised-98 to measure effectiveness and the CTCAE (Common Terminology Criteria for Adverse Events) version 4 to assess safety. Data from 16 patients who received perospirone and 53 patients who received risperidone were analyzed. The mean age was 70 years in the perospirone group and 73 years in the risperidone group. Both groups showed a significant decrease in the total score of DRS-R-98 after three days of treatment (perospirone: 11.7 (7.9-15.4) to 7.0 (3.3-10.7), difference −4.7, effect size=0.72, p=0.003; risperidone: 15.5 (13.6-17.4) to 12.2 (10.1-14.2), difference −3.3, effect size=0.55, p=0.00). The risperidone group showed significant improvements in sleep-wake cycle disturbance, orientation, attention, and visuospatial ability. In the perospirone group, there was a significant improvement of sleep-wake cycle disturbance. The median daily dose of perospirone was 4 mg/day. There were fewer episodes of somnolence as an adverse event in the perospirone group. Low-dose perospirone was thus found to be effective for the treatment of delirium in patients with advanced cancer and may be associated with fewer episodes of over-sedation as an adverse event.
en-copyright=
kn-copyright=

en-aut-name=InoueShinichiro
en-aut-sei=Inoue
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MaedaIsseki
en-aut-sei=Maeda
en-aut-mei=Isseki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OgawaAsao
en-aut-sei=Ogawa
en-aut-mei=Asao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YoshiuchiKazuhiro
en-aut-sei=Yoshiuchi
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TeradaSeishi
en-aut-sei=Terada
en-aut-mei=Seishi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamadaNorihito
en-aut-sei=Yamada
en-aut-mei=Norihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Neuropsychiatry, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Palliative Care, Senri-Chuo Hospital
kn-affil=

affil-num=3
en-affil=Department of Psycho-Oncology Service, National Cancer Center Hospital East
kn-affil=

affil-num=4
en-affil=Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=5
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=delirium
kn-keyword=delirium
en-keyword=cancer
kn-keyword=cancer
en-keyword=perospirone
kn-keyword=perospirone
en-keyword=risperidone
kn-keyword=risperidone
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=2
article-no=
start-page=121
end-page=127
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Grade of Subchondral Insufficiency Fracture of the Knee and the Presence of a Posterior Shiny-Corner Lesion are Correlated with Duration of Medial Meniscus Posterior Root Tear in Women
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bone marrow edema (BME) after meniscus injury and risk factors for subchondral insufficiency fracture of the knee (SIFK) have been reported. However, their association with medial meniscus posterior root tear (MMPRT) remains unknown. We investigated the association of BME volume (BME-V), posterior shinycorner lesion (PSCL), and SIFK with MMPRT to examine the correlations between BME-V and medial meniscus extrusion (MME), PSCL and duration from injury to the time of magnetic resonance imaging (duration), and SIFK and duration. Twenty-nine patients who underwent surgery for MMPRT were included (mean age, 59.2; range, 39-84). The presence of PSCL, femoral BME-V (cm3), and SIFK grade (1-4) were evaluated. Preoperative factors, such as MME (mm) and duration (weeks), were investigated using multivariate linear/ logistic regression analyses. Multivariate linear regression analysis revealed duration as a significant factor for high-grade SIFK (p<0.01). Multivariate logistic regression analysis revealed duration as a significant factor for the presence of PSCL (odds ratio=0.94, p<0.05). A long duration of MMPRT leads to severe MME and highgrade SIFK (3 and 4), often resulting in knee arthroplasty. Early diagnosis of MMPRT and pullout repair can prevent severe MME and high-grade SIFK.
en-copyright=
kn-copyright=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HiranakaTakaaki
en-aut-sei=Hiranaka
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KamatsukiYusuke
en-aut-sei=Kamatsuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TetsunagaTomonori
en-aut-sei=Tetsunaga
en-aut-mei=Tomonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamaneKentaro
en-aut-sei=Yamane
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=medial meniscus
kn-keyword=medial meniscus
en-keyword=posterior root tear
kn-keyword=posterior root tear
en-keyword=subchondral insufficiency fracture
kn-keyword=subchondral insufficiency fracture
en-keyword=bone marrow edema
kn-keyword=bone marrow edema
en-keyword=meniscus extrusion
kn-keyword=meniscus extrusion
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=1
article-no=
start-page=89
end-page=92
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Completely Video-assisted Thoracoscopic Lobectomy for Congenital Lobar Emphysema in a Young Adult
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Congenital lobar emphysema (CLE) is defined as the hyperinflation of pulmonary lobes due to obstruction of the flow of air via a known or unknown etiology, which causes pressure symptoms in the adjacent organs. CLE is mainly diagnosed in the neonatal period, and very few adult cases have been reported. Here we report a 34-year-old male with muscular dystrophy who was diagnosed with CLE on examination. He underwent a right lower lobectomy via 3-portal completely video-assisted thoracoscopic surgery, and his symptoms improved. Thoracoscopic surgery helped preserve the respiratory muscles and led to the improvement of respiratory function in this patient.
en-copyright=
kn-copyright=

en-aut-name=RyukoTsuyoshi
en-aut-sei=Ryuko
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoHiromasa
en-aut-sei=Yamamoto
en-aut-mei=Hiromasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SugimotoSeiichiro
en-aut-sei=Sugimoto
en-aut-mei=Seiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SuzawaKen
en-aut-sei=Suzawa
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MiyoshiKentaroh
en-aut-sei=Miyoshi
en-aut-mei=Kentaroh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OtaniShinji
en-aut-sei=Otani
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkazakiMikio
en-aut-sei=Okazaki
en-aut-mei=Mikio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YamaneMasaomi
en-aut-sei=Yamane
en-aut-mei=Masaomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Thoracic Surgery, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Thoracic Surgery, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Thoracic Surgery, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Thoracic Surgery, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Thoracic Surgery, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Thoracic Surgery, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Thoracic Surgery, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Thoracic Surgery, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Thoracic Surgery, Okayama University Hospital
kn-affil=
en-keyword=congenital lobar emphysema, 
kn-keyword=congenital lobar emphysema, 
en-keyword=adult, 
kn-keyword=adult, 
en-keyword=lobectomy, 
kn-keyword=lobectomy, 
en-keyword=completely video-assisted thoracoscopic surgery, 
kn-keyword=completely video-assisted thoracoscopic surgery, 
en-keyword=muscular dystrophy
kn-keyword=muscular dystrophy
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=1
article-no=
start-page=63
end-page=70
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Chidamide and Decitabine in Combination with a HAG Priming Regimen for Acute Myeloid Leukemia with TP53 Mutation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We analyzed the treatment effects of chidamide and decitabine in combination with a HAG (homoharringtonine, cytarabine, G-CSF) priming regimen (CDHAG) in acute myeloid leukemia (AML) patients with TP53 mutation. Seven TP53 mutated AML patients were treated with CDHAG. The treatment effects were assessed using hemogram detection and bone marrow aspirate. The possible side effects were evaluated based on both hematological and non-hematological toxicity. Four of the seven patients were classified as having achieved complete remission after CDHAG treatment; one patient was considered to have achieved partial remission, and the remaining two patients were considered in non-remission. The overall response rate (ORR) to CDHAG was 71.4%. Regarding the side effects, the hematological toxicity level of the seven patients ranged from level III to level IV, and infections that occurred at lung, blood, and skin were recorded. Nausea, vomiting, liver injury, and kidney injury were also detected. However, all side effects were attenuated by proper management. The CDHAG regimen clearly improved the ORR (71.4%) of TP53-mutated AML patients, with no severe side effects.
en-copyright=
kn-copyright=

en-aut-name=ZhangBei
en-aut-sei=Zhang
en-aut-mei=Bei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=PeiZhixin
en-aut-sei=Pei
en-aut-mei=Zhixin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangHongxia
en-aut-sei=Wang
en-aut-mei=Hongxia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WuHuimin
en-aut-sei=Wu
en-aut-mei=Huimin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WangJunjie
en-aut-sei=Wang
en-aut-mei=Junjie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=BaiJunjun
en-aut-sei=Bai
en-aut-mei=Junjun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SongQinglin
en-aut-sei=Song
en-aut-mei=Qinglin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Hematology, Jiaozuo People’s Hospital
kn-affil=

affil-num=2
en-affil=Department of Hematology, Jiaozuo People’s Hospital
kn-affil=

affil-num=3
en-affil=Department of Hematology, Jiaozuo People’s Hospital
kn-affil=

affil-num=4
en-affil=Department of Hematology, Jiaozuo People’s Hospital
kn-affil=

affil-num=5
en-affil=Department of Hematology, Jiaozuo People’s Hospital
kn-affil=

affil-num=6
en-affil=Department of Hematology, Jiaozuo People’s Hospital
kn-affil=

affil-num=7
en-affil=Department of Hematology, Jiaozuo People’s Hospital
kn-affil=
en-keyword=acute myeloid leukemia
kn-keyword=acute myeloid leukemia
en-keyword=chidamide
kn-keyword=chidamide
en-keyword=decitabine
kn-keyword=decitabine
en-keyword=HAG
kn-keyword=HAG
en-keyword=TP53 mutation
kn-keyword=TP53 mutation
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=1
article-no=
start-page=57
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=In Vivo Microwave Ablation of Normal Swine Lung at High-power, Short-duration Settings
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To evaluate the volume and heat-sink effects of microwave ablation (MWA) in the ablation zone of the normal swine lung. MWA at 100 W was performed for 1, 2, and 3 min in 7, 5, and 5 lung zones, respectively. We assessed the histopathology in the ablation zones and other outcome measures: namely, length of the longest long and short axes, sphericity, ellipsoid area, and ellipsoid volume. The mean long- and short-axis diameters were 22.0 and 14.1 mm in the 1-min ablation zone, 27.6 and 20.2 mm in the 2-min ablation zone; and 29.2 and 21.2 mm in the 3-min ablation zone, respectively. All measures, except sphericity, were significantly less with 1-min ablation than with either 2- or 3-min ablation. There were no significant differences between the 2- and 3-min ablation zones, but all measures except sphericity were larger with 3-min ablation. Although there were no blood vessels that resulted in a heat-sink effect within the ablation zones, the presence of bronchi nearby in 5 lung ablation zones resulted in reduced ablation size. In high-power, short-duration MWA, the lung ablation volume was affected by ablation time. Some ablations showed that a heat-sink effect by a neighboring bronchus might occur.
en-copyright=
kn-copyright=

en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TojiTomohiro
en-aut-sei=Toji
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KomakiToshiyuki
en-aut-sei=Komaki
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KanazawaSusumu
en-aut-sei=Kanazawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Pathology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=microwave ablation
kn-keyword=microwave ablation
en-keyword=lung
kn-keyword=lung
en-keyword=ablation zone
kn-keyword=ablation zone
en-keyword=heat-sink effect
kn-keyword=heat-sink effect
en-keyword=swine
kn-keyword=swine
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=5
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mouse Model for Optogenetic Genome Engineering
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Optogenetics, a technology to manipulate biological phenomena thorough light, has attracted much attention in neuroscience. Recently, the Magnet System, a photo-inducible protein dimerization system which can control the intracellular behavior of various biomolecules with high accuracy using light was developed. Furthermore, photoactivation systems for controlling biological phenomena are being developed by combining this technique with genome-editing technology (CRISPR/Cas9 System) or DNA recombination technology (Cre-loxP system). Herein, we review the history of optogenetics and the latest Magnet System technology and introduce our recently developed photoactivatable Cre knock-in mice with temporal-, spatial-, and cell-specific accuracy.
en-copyright=
kn-copyright=

en-aut-name=TakaoTomoka
en-aut-sei=Takao
en-aut-mei=Tomoka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamadaDaisuke
en-aut-sei=Yamada
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakaradaTakeshi
en-aut-sei=Takarada
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=optogenetics
kn-keyword=optogenetics
en-keyword=Cre recombinase
kn-keyword=Cre recombinase
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=6
article-no=
start-page=699
end-page=704
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Guideline-based Treatment of Glucocorticoid-induced Osteoporosis in Patients with Rheumatoid Arthritis: A Retrospective Study with the AORA Registry
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Glucocorticoid-induced osteoporosis (GIOP) is one of the side effects associated with glucocorticoid (GC) therapy. In 2014, the Japanese Society for Bone and Mineral Research (JSBMR) provided new guidelines for the management and treatment of GIOP. The aim of the present study was to clarify the prevalence of patients with rheumatoid arthritis (RA) requiring treatment according to the new guidelines and to identify risk factors associated with lack of treatment in these patients. Patients in the 2018 Akita Orthopedic group on Rheumatoid Arthritis (AORA) database were enrolled. Of 2,234 patients with RA in the database, 683 (30.6%) met the 2014 JSBMR guideline treatment criteria, and 480 (70.3%) had been treated. The untreated group included a larger number of males, younger patients, and patients treated in clinics rather than hospital (p<0.001, p=0.015, and p<0.001, respectively). Multivariate analyses found that male sex, younger age, and clinic-based RA care were significant risk factors associated with lack of treatment (p<0.001, p=0.013, and p<0.001, respectively). Thus, male sex, younger age, and clinic-based care were identified as risk factors
en-copyright=
kn-copyright=

en-aut-name=KawanoTetsuya
en-aut-sei=Kawano
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyakoshiNaohisa
en-aut-sei=Miyakoshi
en-aut-mei=Naohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TsuchieHiroyuki
en-aut-sei=Tsuchie
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KashiwaguraTakeshi
en-aut-sei=Kashiwagura
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KobayashiMoto
en-aut-sei=Kobayashi
en-aut-mei=Moto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AonumaHiroshi
en-aut-sei=Aonuma
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SugimuraYusuke
en-aut-sei=Sugimura
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShimadaYoichi
en-aut-sei=Shimada
en-aut-mei=Yoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Orthopedic Surgery, Akita City Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthopedic Surgery, Hiraka General Hospital Yokote City
kn-affil=

affil-num=6
en-affil=Department of Orthopedic Surgery, Ogachi Central Hospital Yuzawa City
kn-affil=

affil-num=7
en-affil=Department of Orthopedic Surgery, Nakadori General Hospital Akita City
kn-affil=

affil-num=8
en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine
kn-affil=
en-keyword=glucocorticoid
kn-keyword=glucocorticoid
en-keyword=glucocorticoid-induced osteoporosis
kn-keyword=glucocorticoid-induced osteoporosis
en-keyword=rheumatoid arthritis
kn-keyword=rheumatoid arthritis
en-keyword=osteoporosis
kn-keyword=osteoporosis
en-keyword=osteopenia
kn-keyword=osteopenia
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=5
article-no=
start-page=585
end-page=593
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Factors for Acute Kidney Injury Following Total Arch Replacement and Association with Temperature Management During Cardiopulmonary Bypass: A Single-center Retrospective Observational Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Many patients develop acute kidney injury (AKI) after vascular surgery. In this retrospective observational study, we investigated the risk factors for AKI defined using the Kidney Disease Improving Global Outcomes criteria after total arch replacement (TAR). Additionally, we investigated the influence of temperature manage-ment during cardiopulmonary bypass (CPB) on postoperative renal function by propensity score-matched anal-ysis. We retrospectively analyzed 161 consecutive patients who underwent TAR between 2016 and 2019. Postoperative AKI occurred in 48.7% of the patients. In the multivariate analysis, male sex (odds ratio [OR] 3.95, 95% confidence interval [95%CI] 1.56-8.27, p = 0.002), ACE inhibitors/ARB medication (OR 3.19, 95%CI 1.49-6.82, p = 0.003), preoperative chronic kidney disease (OR 2.47, 95%CI 1.17-5.23, p = 0.02), pro-longed CPB time (OR 2.36, 95%CI 1.05-5.34, p = 0.04), and lower body ischemic time during CPB (OR 2.20, 95%CI 1.05-4.46, p = 0.04) were identified as independent risk factors for AKI. Propensity score-matched anal-ysis showed no significant difference in the risk of AKI following TAR between mild hypothermia or normo-thermia and moderate hypothermia (37.2% vs. 41.9%, p = 0.83). In conclusion, modifiable risk factors for AKI included prolonged CPB time and lower body ischemic time. Temperature management during CPB had no clear effect on outcomes.
en-copyright=
kn-copyright=

en-aut-name=OmiyaHiroki
en-aut-sei=Omiya
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakatoriMakoto
en-aut-sei=Takatori
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YunokiKeiji
en-aut-sei=Yunoki
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Critical Care Medicine, Hiroshima Citizens Hospital
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Critical Care Medicine, Hiroshima Citizens Hospital
kn-affil=

affil-num=3
en-affil=Department of Cardiovascular Surgery, Hiroshima Citizens Hospital
kn-affil=

affil-num=4
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=
en-keyword=acute kidney injury
kn-keyword=acute kidney injury
en-keyword=total arch replacement
kn-keyword=total arch replacement
en-keyword=cardiopulmonary bypass
kn-keyword=cardiopulmonary bypass
en-keyword=lower body ischemic time
kn-keyword=lower body ischemic time
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=4
article-no=
start-page=539
end-page=542
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Elderly Male with Primary Sjögren’s Syndrome Presenting Pleuritis as the Initial Manifestation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Primary Sjögren’s syndrome (SS) is an autoimmune disease that usually affects the exocrine glands in mid-dle-aged women. Fifteen percent of SS patients experience severe systemic extraglandular complications, and pleuritis is one of the rare complications of SS. We report the case of an elderly Japanese man who initially pre-sented with a prolonged fever and chest pain and was finally diagnosed with primary SS-associated pleuritis. Of the nine reported cases of primary SS that initially presented with pleuritis, up to six cases were elderly males. This case highlights the complication of pleuritis among elderly males with primary SS.
en-copyright=
kn-copyright=

en-aut-name=YamamotoYukichika
en-aut-sei=Yamamoto
en-aut-mei=Yukichika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OtsukaYuki
en-aut-sei=Otsuka
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatsuyamaTakayuki
en-aut-sei=Katsuyama
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NishimuraYoshito
en-aut-sei=Nishimura
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkaKosuke
en-aut-sei=Oka
en-aut-mei=Kosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HasegawaKou
en-aut-sei=Hasegawa
en-aut-mei=Kou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Sjögren’s syndrome
kn-keyword=Sjögren’s syndrome
en-keyword=pleuritis
kn-keyword=pleuritis
en-keyword=elderly male
kn-keyword=elderly male
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=4
article-no=
start-page=423
end-page=430
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Medial Meniscus Posterior Root Repair Using a Modified Mason-Allen Suture Can Prevent the Progression of Cartilage Degeneration on the  Loading Surface of the Medial Compartment: A Second-Look Arthroscopic Evaluation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The treatment of medial meniscus posterior root tears (MMPRTs) has evolved to include a variety of repair strategies. This study investigated the location of the articular cartilage degeneration during second-look arthroscopy after transtibial pullout repair with a modified Mason-Allen suture using FasT-Fix (F-MMA) in 22 patients with MMPRTs. Second-look arthroscopy was performed approximately 1 year postoperatively to eval-uate the healing status of the medial meniscus (MM). Articular cartilage degeneration was assessed using the International Cartilage Repair Society grade at primary surgery and again at second-look arthroscopy. Articular surfaces of the medial/lateral femoral condyles, the medial/lateral tibial plateaus, the patella and the trochlea were divided into several subcompartments (MF 1-9, LF 1-9, MT 1-5, LT 1-5, P 1-9, T 1-3). Clinical evaluations used the Japanese Knee Injury and Osteoarthritis Outcome, Lysholm, and International Knee Documentation Committee scores. Second-look arthroscopic findings showed complete healing of the MM posterior root in all patients. Significant differences between pullout repair and second-look arthroscopy were observed for MF 2 and 4, LF 7, and P 7. All clinical outcomes were improved. Our results indicate that this technique improves clinical outcomes postoperatively and may prevent the progression of cartilage degenera-tion on the loading surface of the medial knee compartment.
en-copyright=
kn-copyright=

en-aut-name=TakihiraShota
en-aut-sei=Takihira
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HiranakaTakaaki
en-aut-sei=Hiranaka
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KintakaKeisuke
en-aut-sei=Kintaka
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KodamaYuya
en-aut-sei=Kodama
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KamatsukiYusuke
en-aut-sei=Kamatsuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MiyazawaShinichi
en-aut-sei=Miyazawa
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OzakiToshifumi 
en-aut-sei=Ozaki
en-aut-mei=Toshifumi 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=articular cartilage
kn-keyword=articular cartilage
en-keyword=medial meniscus
kn-keyword=medial meniscus
en-keyword=modified Mason-Allen suture technique
kn-keyword=modified Mason-Allen suture technique
en-keyword=posterior root tear
kn-keyword=posterior root tear
en-keyword=second-look arthroscopy
kn-keyword=second-look arthroscopy
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=1
article-no=
start-page=11086
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210527
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Leucine-rich alpha-2 glycoprotein as a marker of mucosal healing in inflammatory bowel disease
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Leucine-rich alpha-2 glycoprotein (LRG) may be a novel serum biomarker for patients with inflammatory bowel disease. The association of LRG with the endoscopic activity and predictability of mucosal healing (MH) was determined and compared with those of C-reactive protein (CRP) and fecal markers (fecal immunochemical test [FIT] and fecal calprotectin [Fcal]) in 166 ulcerative colitis (UC) and 56 Crohn's disease (CD) patients. In UC, LRG was correlated with the endoscopic activity and could predict MH, but the performance was not superior to that of fecal markers (areas under the curve [AUCs] for predicting MH: LRG: 0.61, CRP: 0.59, FIT: 0.75, and Fcal: 0.72). In CD, the performance of LRG was equivalent to that of CRP and Fcal (AUCs for predicting MH: LRG: 0.82, CRP: 0.82, FIT: 0.70, and Fcal: 0.88). LRG was able to discriminate patients with MH from those with endoscopic activity among UC and CD patients with normal CRP levels. LRG was associated with endoscopic activity and could predict MH in both UC and CD patients. It may be particularly useful in CD.
en-copyright=
kn-copyright=

en-aut-name=YasutomiEriko
en-aut-sei=Yasutomi
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=InokuchiToshihiro
en-aut-sei=Inokuchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HiraokaSakiko
en-aut-sei=Hiraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakeiKensuke
en-aut-sei=Takei
en-aut-mei=Kensuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IgawaShoko
en-aut-sei=Igawa
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamamotoShumpei
en-aut-sei=Yamamoto
en-aut-mei=Shumpei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OhmoriMasayasu
en-aut-sei=Ohmori
en-aut-mei=Masayasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OkaShohei
en-aut-sei=Oka
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamasakiYasushi
en-aut-sei=Yamasaki
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KinugasaHideaki
en-aut-sei=Kinugasa
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TakaharaMasahiro
en-aut-sei=Takahara
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HaradaKeita
en-aut-sei=Harada
en-aut-mei=Keita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=FurukawaMasaki
en-aut-sei=Furukawa
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=ItoshimaKouichi
en-aut-sei=Itoshima
en-aut-mei=Kouichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=OkadaKen
en-aut-sei=Okada
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=KatoJun
en-aut-sei=Kato
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Laboratory Medicine, Okayama University Hospital
kn-affil=

affil-num=14
en-affil=Department of Laboratory Medicine, Okayama University Hospital
kn-affil=

affil-num=15
en-affil=Department of Laboratory Medicine, Okayama University Hospital
kn-affil=

affil-num=16
en-affil=Department of Laboratory Medicine, Okayama University Hospital
kn-affil=

affil-num=17
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=18
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=19
en-affil=Department of Gastroenterology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=20
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=3
article-no=
start-page=335
end-page=343
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Baseline Neutrophil-to-Lymphocyte Ratio and Glasgow Prognostic Score are Associated with Clinical Outcome in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Treated with Nivolumab
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC) has a poor prognosis. Although nivolumab is approved in Japan for treating R/MHNSCC, the response rate is low. Therefore, identifying pretreatment prognostic factors is necessary. This study assessed the utility of the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS) as biomarkers of response to nivolumab. We retrospectively collected the data of 56 R/MHNSCC patients treated with nivolumab between May 2017 and December 2019. The Kaplan–Meier method and log-rank test were used to estimate overall survival (OS) and progression-free survival (PFS), and multivariate Cox hazard regression analysis was used to identify independent predictors of survival. Patients with a low pretreatment NLR had prolonged OS, and patients with a low pretreatment GPS had increased OS and PFS. A performance score (PS) of 0-1, development of immune-related adverse events, and GPS of 0-1 were significantly associated with OS in multivariate analysis. In summary, baseline pretreatment NLR and GPS are independently associated with OS in R/MHNSCC patients treated with nivolumab. Administration of nivolumab while maintaining the PS reflects a immune status of the host and leads to a good OS.
en-copyright=
kn-copyright=

en-aut-name=ChikuieNobuyuki
en-aut-sei=Chikuie
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HamamotoTakao
en-aut-sei=Hamamoto
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UedaTsutomu
en-aut-sei=Ueda
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TaruyaTakayuki
en-aut-sei=Taruya
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KonoTakashi
en-aut-sei=Kono
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FuruieHiromi
en-aut-sei=Furuie
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IshinoTakashi
en-aut-sei=Ishino
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakenoSachio
en-aut-sei=Takeno
en-aut-mei=Sachio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=2
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=3
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=4
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=5
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=6
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Kure Medical Center and Chugoku Cancer Center
kn-affil=

affil-num=7
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=8
en-affil=Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=
en-keyword=neutrophil-to-lymphocyte ratio
kn-keyword=neutrophil-to-lymphocyte ratio
en-keyword=nivolumab
kn-keyword=nivolumab
en-keyword=Glasgow Prognostic Score
kn-keyword=Glasgow Prognostic Score
en-keyword=recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC)
kn-keyword=recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC)
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=3
article-no=
start-page=279
end-page=287
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Gram-negative Rod Blood Stream Infection on Acute GVHD in Allogeneic Hematopoietic Stem Cell Transplantation: A Single-institute Analysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A bloodstream infection (BSI) is the most common serious infectious complication of hematopoietic stem cell transplantation (HSCT). BSI promotes an inflammatory state, which exacerbates acute graft-versus-host disease (GVHD). We investigated whether a Gram-negative rod bloodstream infection (GNR-BSI), which develops early after allo-HSCT, affected the onset or exacerbated acute GVHD in 465 patients who underwent allo-HSCT from 1995 through 2015 at a single institution. Eighty-eight patients (19%) developed BSI during the study period. Among the cultures, 50 (57%) were Gram-positive cocci (GPC) and 31 (35%) were GNR. Of the 465 patients, 187 (40%) developed acute GVHD of grade II or higher within the first 100 days post-allogeneic HSCT: 124 (27%) had acute GVHD grade II, 47 (10%) had grade III, and 16 (3%) had grade IV. Multivariate analysis revealed that GNR-BSI was a significant risk factor for grade II-IV acute GVHD (grade II-IV: hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.03-2.97; grade III-IV: HR 2.37, 95% CI 1.03-5.43). These results suggest that GNR-BSI may predict the onset and exacerbation of acute GVHD.
en-copyright=
kn-copyright=

en-aut-name=NishinoharaMasa-aki
en-aut-sei=Nishinohara
en-aut-mei=Masa-aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishimoriHisakazu
en-aut-sei=Nishimori
en-aut-mei=Hisakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiwaraHideaki
en-aut-sei=Fujiwara
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AsadaNoboru
en-aut-sei=Asada
en-aut-mei=Noboru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=EnnishiDaisuke
en-aut-sei=Ennishi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsuokaKen-ichi
en-aut-sei=Matsuoka
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FujiiKeiko
en-aut-sei=Fujii
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=FujiiNobuharu
en-aut-sei=Fujii
en-aut-mei=Nobuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=blood stream infection
kn-keyword=blood stream infection
en-keyword=graft-versus-host disease
kn-keyword=graft-versus-host disease
en-keyword=gram negative rods
kn-keyword=gram negative rods
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=2
article-no=
start-page=231
end-page=238
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Long-term Survival with a Rare Advanced Primary Gastrointestinal Malignant Melanoma Treated with Laparoscopic Surgery/Immune Checkpoint Inhibitor
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years.  Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
en-copyright=
kn-copyright=

en-aut-name=EndoMotochika
en-aut-sei=Endo
en-aut-mei=Motochika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YanoShuya
en-aut-sei=Yano
en-aut-mei=Shuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AsanoHiroaki
en-aut-sei=Asano
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakedaSho
en-aut-sei=Takeda
en-aut-mei=Sho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HamadaYuki
en-aut-sei=Hamada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KondoYoshitaka
en-aut-sei=Kondo
en-aut-mei=Yoshitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KurodaShinji
en-aut-sei=Kuroda
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShigeyasuKunitoshi
en-aut-sei=Shigeyasu
en-aut-mei=Kunitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KikuchiSatoru
en-aut-sei=Kikuchi
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TeraishiFuminori
en-aut-sei=Teraishi
en-aut-mei=Fuminori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=NishizakiMasahiko
en-aut-sei=Nishizaki
en-aut-mei=Masahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Surgery, Mitoyo general Hospital
kn-affil=

affil-num=4
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Pathology, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=primary gastrointestinal melanoma
kn-keyword=primary gastrointestinal melanoma
en-keyword=laparoscopic surgery
kn-keyword=laparoscopic surgery
en-keyword=immune checkpoint antibody-blockade inhibitor
kn-keyword=immune checkpoint antibody-blockade inhibitor
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=2
article-no=
start-page=225
end-page=230
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histological Analysis of Repaired Tissue after Pullout Repair of a Medial Meniscus Posterior Root Tear
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 65-year-old man presented with a left medial meniscus (MM) posterior root tear (PRT). Unicompartmental knee arthroplasty was performed 12 months after transtibial pullout repair of the MMPRT. Repaired MM posterior root tissue was subjected to histological analysis. Immunostaining and picrosirius red staining showed sufficient deposition of type I collagen, and hematoxylin-eosin staining using a polarized microscope showed well-aligned fiber orientation in the repaired tissue. The repaired posterior root (post-transtibial pullout repair) showed mature and well-aligned ligament-like tissue. Preserving the MM posterior root remnant to mimic the original posterior root tissue might be useful when performing pullout repair.
en-copyright=
kn-copyright=

en-aut-name=XueHaowei
en-aut-sei=Xue
en-aut-mei=Haowei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkazakiYuki 
en-aut-sei=Okazaki
en-aut-mei=Yuki 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HiranakaTakaaki
en-aut-sei=Hiranaka
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KintakaKeisuke 
en-aut-sei=Kintaka
en-aut-mei=Keisuke 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ZhangXiming
en-aut-sei=Zhang
en-aut-mei=Ximing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=medial meniscus
kn-keyword=medial meniscus
en-keyword=posterior root tear
kn-keyword=posterior root tear
en-keyword=unicompartmental knee arthroplasty
kn-keyword=unicompartmental knee arthroplasty
en-keyword=histological analysis
kn-keyword=histological analysis
en-keyword=case report
kn-keyword=case report
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=2
article-no=
start-page=219
end-page=224
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Successful Treatment of Acute Promyelocytic Leukemia Complicated with Endometrial Cancer by Arsenic Trioxide
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor’s treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer.
en-copyright=
kn-copyright=

en-aut-name=SugiuraHiroyuki
en-aut-sei=Sugiura
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishimoriHisakazu
en-aut-sei=Nishimori
en-aut-mei=Hisakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsuokaHirofumi
en-aut-sei=Matsuoka
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakamuraKeiichiro
en-aut-sei=Nakamura
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiiKeiko
en-aut-sei=Fujii
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FujiiNobuharu 
en-aut-sei=Fujii
en-aut-mei=Nobuharu 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsuokaKen-ichi 
en-aut-sei=Matsuoka
en-aut-mei=Ken-ichi 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=acute promyelocytic leukemia
kn-keyword=acute promyelocytic leukemia
en-keyword=endometrial cancer
kn-keyword=endometrial cancer
en-keyword=arsenic trioxide
kn-keyword=arsenic trioxide
en-keyword=synchronous multiple primary malignant tumor
kn-keyword=synchronous multiple primary malignant tumor
en-keyword=chemotherapy
kn-keyword=chemotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=2
article-no=
start-page=147
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Knee Flexion-induced Translation of Pullout Sutures Used in the Repair of Medial Meniscus Posterior Root Tears
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Medial meniscus posterior root tears (MMPRTs) have recently attracted considerable interest in orthopedics. To date, no in vivo human study has investigated suture translation changes in repaired MMPRTs with different degrees of knee flexion. This study examined suture translation at various degrees of knee flexion in 30 patients undergoing medial meniscus posterior root repair using the modified Mason-Allen suture technique between August 2016 and September 2017. Intraoperatively, sutures were provisionally fixed to an isometric positioner at the tibial site of the desired meniscal attachment, and the suture translation was measured at 0°, 30°, 60°, and 90° of knee flexion. The results showed significant increases in mean suture translation at the knee flexion positions from 0° to 30°, 30° to 60°, and 60° to 90° (p<0.01 for all). Our findings indicate that surgeons should carefully assess the degree of knee flexion at the moment when the meniscus is refixed by surgical sutures.
en-copyright=
kn-copyright=

en-aut-name=XueHaowei 
en-aut-sei=Xue
en-aut-mei=Haowei 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkazakiYuki 
en-aut-sei=Okazaki
en-aut-mei=Yuki 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HiranakaTakaaki 
en-aut-sei=Hiranaka
en-aut-mei=Takaaki 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KintakaKeisuke 
en-aut-sei=Kintaka
en-aut-mei=Keisuke 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FujiiMasataka 
en-aut-sei=Fujii
en-aut-mei=Masataka 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ZhangXiming
en-aut-sei=Zhang
en-aut-mei=Ximing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=medial meniscus
kn-keyword=medial meniscus
en-keyword=posterior root tear
kn-keyword=posterior root tear
en-keyword=suture translation
kn-keyword=suture translation
en-keyword=knee flexion
kn-keyword=knee flexion
en-keyword=arthroscopic repair
kn-keyword=arthroscopic repair
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=4
article-no=
start-page=336
end-page=342
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200129
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The presence of chronic diseases contributes to the occurrence risk factors for gynecological cancers in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of the present study was to determine whether chronic diseases (CD), such as hypertension, diabetes mellitus, dyslipidemia, heart diseases and cerebrovascular diseases, are occurrence risk factors and affect the survival of patients with gynecological cancers (GC). The correlations between CD and the characteristics and survival of 1,590 GC patients [685 with cervical cancer (CC), 613 with endometrial cancer (EM) and 292 with ovarian cancer (OV)] were investigated in the present study. Of the CD patients, 189 had CC (27.6%), 265 had EM (43.2%) and 72 had OV (24.7%). The incidence of CD increased with age in GC patients. The number of CD patients aged ≥70 years, was 8.6‑fold higher in the CC group, 3.0‑fold higher in the EM group, and 9.6‑fold higher in the OV group compared with those aged <50 years. CD and excess body weight were associated with GC regardless of patient age. However, there was no correlation between CD and survival at any age in GC patients. These findings indicate that CD contribute to >24% of the occurrence risk factors in GC patients in Japan.
en-copyright=
kn-copyright=

en-aut-name=OkamotoKazuhiro
en-aut-sei=Okamoto
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraKeiichiro
en-aut-sei=Nakamura
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsuokaHirofumi
en-aut-sei=Matsuoka
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsubaraYuko
en-aut-sei=Matsubara
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HaragaJunko
en-aut-sei=Haraga
en-aut-mei=Junko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OgawaChikako
en-aut-sei=Ogawa
en-aut-mei=Chikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MasuyamaHisashi
en-aut-sei=Masuyama
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=gynecological cancer
kn-keyword=gynecological cancer
en-keyword=chronic diseases
kn-keyword=chronic diseases
en-keyword=occurrence risk factors
kn-keyword=occurrence risk factors
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=6
article-no=
start-page=531
end-page=535
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Soft Tissue Myoepithelioma of the Shoulder
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Soft tissue myoepitheliomas are often misdiagnosed due to their rarity. Herein, we describe a case of soft tissue myoepithelioma of the shoulder. A 72-year-old woman had a suspected sarcoma on her shoulder and under-went open biopsy. She was referred to our hospital, where the tumor was widely resected and the diagnosis of myoepithelioma was histologically confirmed. No recurrence has been observed in the 3 years since the sur-gery. Careful and prompt planning is necessary for the effective treatment of myoepithelioma.
en-copyright=
kn-copyright=

en-aut-name=HashimotoKazuhiko
en-aut-sei=Hashimoto
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishimuraShunji
en-aut-sei=Nishimura
en-aut-mei=Shunji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ChikugoTakaaki
en-aut-sei=Chikugo
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KakinokiRyosuke
en-aut-sei=Kakinoki
en-aut-mei=Ryosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AkagiMasao
en-aut-sei=Akagi
en-aut-mei=Masao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Orthopedic Surgery, Kindai University Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthopedic Surgery, Kindai University Hospital
kn-affil=

affil-num=3
en-affil=Department of Pathology, Kindai University Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopedic Surgery, Kindai University Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthopedic Surgery, Kindai University Hospital
kn-affil=
en-keyword=soft tissue myoepithelioma
kn-keyword=soft tissue myoepithelioma
en-keyword=unplanned resection
kn-keyword=unplanned resection
en-keyword=shoulder
kn-keyword=shoulder
END

start-ver=1.4
cd-journal=joma
no-vol=269
cd-vols=
no-issue=
article-no=
start-page=115934
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201109
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cadmium transfer in contaminated soil-rice systems: Insights from solid-state speciation analysis and stable isotope fractionation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Initial Cadmium (Cd) isotope fractionation studies in cereals ascribed the retention of Cd and its light isotopes to the binding of Cd to sulfur (S). To better understand the relation of Cd binding to S and Cd isotope fractionation in soils and plants, we combined isotope and XAS speciation analyses in soil-rice systems that were rich in Cd and S. The systems included distinct water management (flooded vs. non-flooded) and rice accessions with (excluder) and without (non-excluder) functional membrane transporter OsHMA3 that transports Cd into root vacuoles. Initially, 13% of Cd in the soil was bound to S. Through soil flooding, the proportion of Cd bound to S increased to 100%. Soil flooding enriched the rice plants towards heavy isotopes (δ114/110Cd = −0.37 to −0.39%) compared to the plants that grew on non-flooded soils (δ114/110Cd = −0.45 to −0.56%) suggesting that preferentially light Cd isotopes precipitated into Cd sulfides. Isotope compositions in CaCl2 root extracts indicated that the root surface contributed to the isotope shift between soil and plant during soil flooding. In rice roots, Cd was fully bound to S in all treatments. The roots in the excluder rice strongly retained Cd and its lights isotopes while heavy isotopes were transported to the shoots (Δ114/110Cdshoot-root 0.16–0.19‰). The non-excluder rice accumulated Cd in shoots and the apparent difference in isotope composition between roots and shoots was smaller than that of the excluder rice (Δ114/110Cdshoot-root −0.02 to 0.08‰). We ascribe the retention of light Cd isotopes in the roots of the excluder rice to the membrane transport of Cd by OsHMA3 and/or chelating Cd–S complexes in the vacuole. Cd–S was the major binding form in flooded soils and rice roots and partly contributed to the immobilization of Cd and its light isotopes in soil-rice systems.
en-copyright=
kn-copyright=

en-aut-name=WiggenhauserMatthias
en-aut-sei=Wiggenhauser
en-aut-mei=Matthias
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AucourAnne-Marie
en-aut-sei=Aucour
en-aut-mei=Anne-Marie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BureauSarah
en-aut-sei=Bureau
en-aut-mei=Sarah
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=CampilloSylvain
en-aut-sei=Campillo
en-aut-mei=Sylvain
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TeloukPhilippe
en-aut-sei=Telouk
en-aut-mei=Philippe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=RomaniMarco
en-aut-sei=Romani
en-aut-mei=Marco
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MaJian Feng
en-aut-sei=Ma
en-aut-mei=Jian Feng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=LandrotGautier
en-aut-sei=Landrot
en-aut-mei=Gautier
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SarretGéraldine
en-aut-sei=Sarret
en-aut-mei=Géraldine
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Univ. Grenoble Alpes
kn-affil=

affil-num=2
en-affil=Université de Lyon
kn-affil=

affil-num=3
en-affil=Univ. Grenoble Alpes
kn-affil=

affil-num=4
en-affil=Univ. Grenoble Alpes
kn-affil=

affil-num=5
en-affil=Université de Lyon
kn-affil=

affil-num=6
en-affil=Centro Ricerche sul Riso, Ente Nazionale Risi, Strada per Ceretto
kn-affil=

affil-num=7
en-affil=nstitute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=8
en-affil=Synchrotron SOLEIL, L’Ormes des Merisiers
kn-affil=

affil-num=9
en-affil=Univ. Grenoble Alpes
kn-affil=
en-keyword=Cadmium
kn-keyword=Cadmium
en-keyword=Rice
kn-keyword=Rice
en-keyword=Isotopes
kn-keyword=Isotopes
en-keyword=Speciation
kn-keyword=Speciation
en-keyword=Membrane transporter
kn-keyword=Membrane transporter
en-keyword=Vacuole
kn-keyword=Vacuole
en-keyword=Sulfur
kn-keyword=Sulfur
en-keyword=Redox
kn-keyword=Redox
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=5
article-no=
start-page=371
end-page=379
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202010
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Anaplastic Lymphoma Kinase Fusion: A Review of Therapeutic Drugs and Treatment Strategies
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms.
en-copyright=
kn-copyright=

en-aut-name=MakimotoGo
en-aut-sei=Makimoto
en-aut-mei=Go
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhashiKadoaki
en-aut-sei=Ohashi
en-aut-mei=Kadoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Respiratory Medicine, National Hospital Organization Iwakuni Clinical Center
kn-affil=

affil-num=2
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=
en-keyword=lung cancer
kn-keyword=lung cancer
en-keyword=anaplastic lymphoma kinase
kn-keyword=anaplastic lymphoma kinase
en-keyword=tyrosine kinase inhibitors
kn-keyword=tyrosine kinase inhibitors
en-keyword=resistance mechanism
kn-keyword=resistance mechanism
END

start-ver=1.4
cd-journal=joma
no-vol=117
cd-vols=
no-issue=10
article-no=
start-page=101103
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200909
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Super-chiral vibrational spectroscopy with metasurfaces for high-sensitive identification of alanine enantiomers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Chiral nature of an enantiomer can be characterized by circular dichroism (CD) spectroscopy, but such a technique usually suffers from weak signal even with a sophisticated optical instrument. Recent demonstrations of plasmonic metasurfaces showed that chiroptical interaction of molecules can be engineered, thereby greatly simplifying a measurement system with high sensing capability. Here, by exploiting super-chiral field in a metasurface, we experimentally demonstrate high-sensitive vibrational CD spectroscopy of alanine enantiomers, the smallest chiral amino acid. Under linearly polarized excitation, the metasurface consisting of an array of staggered Au nano-rods selectively produces the left- and right-handed super-chiral fields at 1600 cm−1, which spectrally overlaps with the functional group vibrations of alanine. In the Fourier-transform infrared spectrometer measurements, the mirror symmetric CD spectra of D- and L-alanine are clearly observed depending on the handedness of the metasurface, realizing the reliable identification of small chiral molecules. The corresponding numerical simulations reveal the underlying resonant chiroptical interaction of plasmonic modes of the metasurface and vibrational modes of alanine. Our approach demonstrates a high-sensitive vibrational CD spectroscopic technique, opening up a reliable chiral sensing platform for advanced infrared inspection technologies.
en-copyright=
kn-copyright=

en-aut-name=IidaTakumi 
en-aut-sei=Iida
en-aut-mei=Takumi 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshikawaAtsushi
en-aut-sei=Ishikawa
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaTakuo
en-aut-sei=Tanaka
en-aut-mei=Takuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MuranakaAtsuya
en-aut-sei=Muranaka
en-aut-mei=Atsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=UchiyamaMasanobu
en-aut-sei=Uchiyama
en-aut-mei=Masanobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HayashiYasuhiko
en-aut-sei=Hayashi
en-aut-mei=Yasuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TsurutaKenji
en-aut-sei=Tsuruta
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Electrical and Electronic Engineering, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Electrical and Electronic Engineering, Okayama University
kn-affil=

affil-num=3
en-affil=Metamaterials Laboratory, RIKEN Cluster for Pioneering Research
kn-affil=

affil-num=4
en-affil=Advanced Elements Chemistry Laboratory, RIKEN Cluster for Pioneering Research
kn-affil=

affil-num=5
en-affil=Advanced Elements Chemistry Laboratory, RIKEN Cluster for Pioneering Research
kn-affil=

affil-num=6
en-affil=Department of Electrical and Electronic Engineering, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Electrical and Electronic Engineering, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=4
article-no=
start-page=335
end-page=343
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202008
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Recurrence of Solitary Fibrous Tumor/Hemangiopericytoma Could Be Predicted by Ki-67 Regardless of Its Origin
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since the discovery of the NAB2-STAT6 gene fusion in 2013, solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) have been considered the same disease. STAT6 nuclear stain is approved as a highly sensitive and specific marker to diagnose SFT/HPC from other tumors with similar histology. As the next step, detection of fusion variants that may predict clinical malignancy of SFT/HPC has been attempted. However, no fusion variants with a clear relation to malignancy have been identified. In this study, the clinical and histological backgrounds of 23 Japanese patients diagnosed with SFT/HPC from 2000 to 2019 at Kochi University Hospital were examined to identify factors potentially related to recurrence. A significant relationship to recurrence was detected for mitosis ≥ 1/10 HPF (400×), necrosis, and Ki-67>5%. These findings indicate that a deliberate investigation of histological features such as mitosis and necrosis is crucial for the clinical observation of SFT/ HPC patients. In addition, Ki-67 was revealed to be a useful parameter to predict recurrence in SFT/HPC patients.
en-copyright=
kn-copyright=

en-aut-name=YamamotoYumiko
en-aut-sei=Yamamoto
en-aut-mei=Yumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HayashiYoshihiro
en-aut-sei=Hayashi
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MurakamiIchiro
en-aut-sei=Murakami
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Diagnostic Pathology, Kochi University
kn-affil=

affil-num=2
en-affil=Department of Equipment of Support Planning Office, Kochi University
kn-affil=

affil-num=3
en-affil=Department of Diagnostic Pathology, Kochi University
kn-affil=
en-keyword=solitary fibrous tumor
kn-keyword=solitary fibrous tumor
en-keyword=hemangiopericytoma
kn-keyword=hemangiopericytoma
en-keyword=Ki-67
kn-keyword=Ki-67
en-keyword=NAB2-STAT6
kn-keyword=NAB2-STAT6
en-keyword=WHO classification
kn-keyword=WHO classification
en-keyword=WHO grading criteria
kn-keyword=WHO grading criteria
en-keyword=Marseille Grading System
kn-keyword=Marseille Grading System
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=4
article-no=
start-page=275
end-page=283
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202008
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Decreased Serum Antioxidant Marker is Predictive of Early Recurrence in the Same Segment after Radical Ablation for Hepatocellular Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment.
en-copyright=
kn-copyright=

en-aut-name=MuroTaiko
en-aut-sei=Muro
en-aut-mei=Taiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraShinichiro
en-aut-sei=Nakamura
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakakiAkinobu
en-aut-sei=Takaki
en-aut-mei=Akinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnishiHideki
en-aut-sei=Onishi
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WadaNozomu
en-aut-sei=Wada
en-aut-mei=Nozomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YasunakaTetsuya
en-aut-sei=Yasunaka
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=UchidaDaisuke
en-aut-sei=Uchida
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OyamaAtsushi
en-aut-sei=Oyama
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AdachiTakuya
en-aut-sei=Adachi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ShirahaHidenori
en-aut-sei=Shiraha
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=hepatocellular carcinoma
kn-keyword=hepatocellular carcinoma
en-keyword=recurrence,
kn-keyword=recurrence,
en-keyword=radiofrequency ablation
kn-keyword=radiofrequency ablation
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=4
article-no=
start-page=265
end-page=274
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202008
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Factors Predicting a Favorable Disease Course Without Anti-TNF Therapy in Crohn’s Disease Patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.
en-copyright=
kn-copyright=

en-aut-name=InokuchiToshihiro
en-aut-sei=Inokuchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HiraokaSakiko
en-aut-sei=Hiraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YasutomiEriko
en-aut-sei=Yasutomi
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkaShohei
en-aut-sei=Oka
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamasakiYasushi
en-aut-sei=Yamasaki
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KinugasaHideaki
en-aut-sei=Kinugasa
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakaharMasahiro
en-aut-sei=Takahar
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KawanoSeiji
en-aut-sei=Kawano
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HaradaKeita
en-aut-sei=Harada
en-aut-mei=Keita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KatoJun
en-aut-sei=Kato
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=bDepartment of Gastroenterology, Mitsui Memorial Hospital
kn-affil=
en-keyword=Crohn’s disease
kn-keyword=Crohn’s disease
en-keyword=anti-TNF agent
kn-keyword=anti-TNF agent
en-keyword=upper gastrointestinal lesion
kn-keyword=upper gastrointestinal lesion
en-keyword=bamboo joint-like appearance
kn-keyword=bamboo joint-like appearance
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=10
article-no=
start-page=2717
end-page=2725
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190506
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The tonoplast-localized transporter OsHMA3 plays an important role in maintaining Zn homeostasis in rice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to respond to fluctuating zinc (Zn) in the environment, plants must have a system to control Zn homeostasis. However, how plants maintain an appropriate level of Zn during their growth and development is still poorly understood. In this study, we found that OsHMA3, a tonoplast-localized transporter for Zn/Cd, plays an important role in Zn homeostasis in rice. Accessions with the functional allele of OsHMA3 showed greater tolerance to high Zn than those with the non-functional allele based on root elongation test. A 67Zn-labeling experiment showed that accessions with loss of function of OsHMA3 had lower Zn accumulation in the roots but similar concentrations in the shoots compared with functional OsHMA3 accessions. When exposed to Zn-free growing medium, the concentration in the root cell sap was rapidly decreased in accessions with functional OsHMA3, but less dramatic changes were observed in non-functional accessions. A mobility experiment showed that more Zn in the roots was translocated to the shoots in accessions with functional OsHMA3. Higher expression levels of OsZIP4, OsZIP5, OsZIP8, and OsZIP10 were found in the roots of accessions with functional OsHMA3 in response to Zn deficiency. Taken together, our results indicate that OsHMA3 plays an important role in rice roots in both Zn detoxification and storage by sequestration into the vacuoles, depending on Zn concentration in the environment.
en-copyright=
kn-copyright=

en-aut-name=CaiHongmei
en-aut-sei=Cai
en-aut-mei=Hongmei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HuangSheng
en-aut-sei=Huang
en-aut-mei=Sheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=CheJing
en-aut-sei=Che
en-aut-mei=Jing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamajiNaoki
en-aut-sei=Yamaji
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MaJian Feng
en-aut-sei=Ma
en-aut-mei=Jian Feng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=OsHMA3
kn-keyword=OsHMA3
en-keyword=vacuolar sequestration
kn-keyword=vacuolar sequestration
en-keyword=ZIP transporter
kn-keyword=ZIP transporter
en-keyword=Zn distribution
kn-keyword=Zn distribution
en-keyword= Zn root-to-shoot mobility
kn-keyword= Zn root-to-shoot mobility
en-keyword=Zn tolerance
kn-keyword=Zn tolerance
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=3
article-no=
start-page=237
end-page=243
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Serum REIC/Dickkopf-3 Protein Level Predicts Disease-Free Survival in Patients with Hepatocellular Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC.
en-copyright=
kn-copyright=

en-aut-name=OyamaAtsushi
en-aut-sei=Oyama
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UchidaDaisuke
en-aut-sei=Uchida
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShirahaHidenori
en-aut-sei=Shiraha
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SawaharaHiroaki
en-aut-sei=Sawahara
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatoRyo
en-aut-sei=Kato
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HoriguchiShigeru
en-aut-sei=Horiguchi
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=enzyme-linked immunosorbent assay
kn-keyword=enzyme-linked immunosorbent assay
en-keyword=liver resection
kn-keyword=liver resection
en-keyword=primary radiofrequency ablation
kn-keyword=primary radiofrequency ablation
en-keyword=Huh7
kn-keyword=Huh7
en-keyword=Hep3B
kn-keyword=Hep3B
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=3
article-no=
start-page=185
end-page=190
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Stem Cell Therapy in Heart Disease: Limitations and Future Possibilities
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Heart diseases are one of the major causes of morbidity and mortality worldwide. Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. Stem cell therapy has emerged as one option for the treatment of a variety of heart diseases. Although a large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach, the results obtained from these clinical studies are inconsistent, and stem cell-based improvements of heart performance and cardiac remodeling were found to be quite limited. Since the precise mechanisms underlying the therapeutic actions of stem cells are still under debate, researchers have developed a variety of strategies to improve and boost the potency of stem cells in repair. In this review, we summarize both the current therapeutic strategies using stem cells and future directions for enhancing stem cell potency.
en-copyright=
kn-copyright=

en-aut-name=SanoToshikazu
en-aut-sei=Sano
en-aut-mei=Toshikazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshigamiShuta
en-aut-sei=Ishigami
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ItoTatsuo
en-aut-sei=Ito
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SanoShunji
en-aut-sei=Sano
en-aut-mei=Shunji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco
kn-affil=

affil-num=2
en-affil=Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco
kn-affil=

affil-num=3
en-affil=Department of Hygiene, Kawasaki Medical University
kn-affil=

affil-num=4
en-affil=Department of Surgery, Division of Pediatric Cardiothoracic Surgery, University of California San Francisco
kn-affil=
en-keyword=heart disease
kn-keyword=heart disease
en-keyword=stem cell
kn-keyword=stem cell
en-keyword=myocardial regeneration
kn-keyword=myocardial regeneration
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=2
article-no=
start-page=184
end-page=191
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190618
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparison of the clinical characteristics of TAFRO syndrome and idiopathic multicentric Castleman disease in general internal medicine: a 6‐year retrospective study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background</br>
Although thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly (TAFRO) syndrome was first described as a variant of idiopathic multicentric Castleman disease (CD), patients with TAFRO syndrome demonstrate more aggressive clinical features. Because these patients may present with fever of unknown origin, general physicians need to recognise its characteristic laboratory data and clinical features during hospitalisation.</br>
Aims</br>
to describe the features, symptoms and characteristics of TAFRO syndrome and to compare them to those of idiopathic CD.</br>
Methods</br>
This was a retrospective study of patients with histopathologically confirmed TAFRO syndrome and idiopathic multicentric CD who were diagnosed and managed between April 2012 and June 2018 in a Japanese university hospital's General Medicine Department.</br>
Results</br>
We found that the hospitalisations were significantly longer among patients with TAFRO syndrome compared to those with idiopathic CD (median: 87 days; range: 34–236 days vs median: 30 days; range: 13–59 days; P < 0.01). Patients with TAFRO syndrome were more likely to present with fever, abdominal pain and elevated inflammatory markers and be misdiagnosed with an infectious disease during the first hospital visit. Approximately 40% of patients with TAFRO syndrome had no radiographically enlarged lymph nodes.</br>
Conclusions</br>
TAFRO syndrome may present as an infectious disease with an aggressive clinical course. Our study highlights the importance of giving significance to chief complaints and laboratory data. Physicians need to recognise the clinical and laboratory features of this disease to avoid missing this potentially fatal disorder.
en-copyright=
kn-copyright=

en-aut-name=NishimuraYoshito
en-aut-sei=Nishimura
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Hanayama Yoshihisa
en-aut-sei=Hanayama
en-aut-mei= Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiiNobuharu
en-aut-sei=Fujii
en-aut-mei=Nobuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KondoEisei
en-aut-sei=Kondo
en-aut-mei=Eisei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=TAFRO syndrome
kn-keyword=TAFRO syndrome
en-keyword=Castleman disease
kn-keyword=Castleman disease
en-keyword=chief complaint
kn-keyword=chief complaint
en-keyword=procalcitonin
kn-keyword=procalcitonin
en-keyword=immunoglobulin
kn-keyword=immunoglobulin
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=2
article-no=
start-page=123
end-page=128
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly.
en-copyright=
kn-copyright=

en-aut-name=FukuharaRyuichiro
en-aut-sei=Fukuhara
en-aut-mei=Ryuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShinyaTakayoshi
en-aut-sei=Shinya
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FukumaShogo
en-aut-sei=Fukuma
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OgawaNanako
en-aut-sei=Ogawa
en-aut-mei=Nanako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MasaokaYoshihisa
en-aut-sei=Masaoka
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MarunakaHidenori
en-aut-sei=Marunaka
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AriokaTadashi
en-aut-sei=Arioka
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KajiMitsumasa
en-aut-sei=Kaji
en-aut-mei=Mitsumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KanazawaSusumu
en-aut-sei=Kanazawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=3
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=4
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=5
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=6
en-affil=Department of Pathology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=7
en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=8
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=9
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=10
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=11
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=
en-keyword=18F-fluorodeoxyglucose positron emission tomography/computed tomography
kn-keyword=18F-fluorodeoxyglucose positron emission tomography/computed tomography
en-keyword=extranodular spread
kn-keyword=extranodular spread
en-keyword=metastasis
kn-keyword=metastasis
en-keyword=oral squamous cell carcinoma
kn-keyword=oral squamous cell carcinoma
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=2
article-no=
start-page=103
end-page=108
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Switching from Treatment with Amlodipine and Atorvastatin Using Two Pills to an Equal Dose of Single-Pill Therapy in Japanese Outpatients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal dose of single-pill therapy, whereas low-density lipoprotein (LDL) cholesterol levels significantly decreased after the medication was switched from 94±24 mg/dl to 89±17 mg/dl (p=0.015). A switch from medication with two separate pills of amlodipine and atorvastatin to an equal dose of single-pill therapy resulted in an overall decrease in LDL cholesterol. The results indicated that the switch to single-pill therapy might be a useful treatment.
en-copyright=
kn-copyright=

en-aut-name=KawadaYasumasa
en-aut-sei=Kawada
en-aut-mei=Yasumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KuboToru
en-aut-sei=Kubo
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BabaYuichi
en-aut-sei=Baba
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HirotaTakayoshi
en-aut-sei=Hirota
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TaniokaKatsutoshi
en-aut-sei=Tanioka
en-aut-mei=Katsutoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamasakiNaohito
en-aut-sei=Yamasaki
en-aut-mei=Naohito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KitaokaHiroaki
en-aut-sei=Kitaoka
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=2
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=3
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=4
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=5
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=6
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=7
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=
en-keyword=hypertension
kn-keyword=hypertension
en-keyword=dyslipidemia
kn-keyword=dyslipidemia
en-keyword=single-pill therapy
kn-keyword=single-pill therapy
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=2
article-no=
start-page=95
end-page=101
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Efficacy of Software to Help Patients Understand Drug for Adjuvant Treatment for Breast Cancer: A Pilot Randomized Controlled Trial
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We assessed the usefulness of ChemoCalc, a software package for calculating drug costs, in helping patients understand these costs. We randomly assigned, in a 1 : 1 ratio, 20 women who had undergone surgery for early breast cancer to a group that discussed adjuvant treatment with their physicians using the ChemoCalc software (ChemoCalc group) or a group that discussed adjuvant treatment without ChemoCalc (Usual Explanation group). The participants completed a five-grade evaluation questionnaire after these discussions. The primary endpoint was the intergroup comparison of the questionnaire scores regarding participants’ understanding of their treatment-associated drug costs. Median age was not significantly different between the ChemoCalc group and Usual Explanation group (57 vs. 50, respectively; p=0.27). Patients in the ChemoCalc group had a significantly higher perceived level of understanding of the drug cost than those in the Usual Explanation group (5 [4-5] vs. 2.5 [1-5], respectively; p=0.002). Scores related to the patients’ perception that understanding drug costs is an important part of breast cancer treatment were also higher in the ChemoCalc group than the Usual Explanation group (5 [2-5] vs. 3 [1-5], respectively; p=0.049). ChemoCalc was found to be useful for understanding drug costs.
en-copyright=
kn-copyright=

en-aut-name=KubaSayaka
en-aut-sei=Kuba
en-aut-mei=Sayaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamanouchiKosho
en-aut-sei=Yamanouchi
en-aut-mei=Kosho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MoritaMichi
en-aut-sei=Morita
en-aut-mei=Michi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SakimuraChika
en-aut-sei=Sakimura
en-aut-mei=Chika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=InamasuEiko
en-aut-sei=Inamasu
en-aut-mei=Eiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HatachiToshiko
en-aut-sei=Hatachi
en-aut-mei=Toshiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OtsuboRyota
en-aut-sei=Otsubo
en-aut-mei=Ryota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatsumotoMegumi
en-aut-sei=Matsumoto
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YanoHiroshi
en-aut-sei=Yano
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MiyamotoJunya
en-aut-sei=Miyamoto
en-aut-mei=Junya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SatoShuntaro
en-aut-sei=Sato
en-aut-mei=Shuntaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=NakagawaHiroo
en-aut-sei=Nakagawa
en-aut-mei=Hiroo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KanetakaKengo
en-aut-sei=Kanetaka
en-aut-mei=Kengo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=TakatsukiMitsuhisa
en-aut-sei=Takatsuki
en-aut-mei=Mitsuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=NagayasuTakeshi
en-aut-sei=Nagayasu
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=EguchiSusumu
en-aut-sei=Eguchi
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=2
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=3
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=4
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=5
en-affil=Department of  Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=6
en-affil=Department of  Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=7
en-affil=Department of  Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=8
en-affil=Department of  Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=9
en-affil=Department of  Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=10
en-affil=Department of Clinical Research Center, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=11
en-affil=Department of Clinical Research Center, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=12
en-affil=Department of Pharmacy, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=13
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=14
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=15
en-affil=Department of  Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=16
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=drug costs
kn-keyword=drug costs
en-keyword=ChemoCalc
kn-keyword=ChemoCalc
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=48
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Prevalence and Characteristics of Older Japanese Adults with Polypharmacy, Based on Regionally Representative Health Insurance Claims Data
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We aimed to clarify the prevalence of polypharmacy among elderly individuals in Japan. We used the data obtained from a large-scale population-based representative database of health insurance claims in a single prefecture in Japan. We examined all of the outpatient and pharmaceutical health insurance claims for National Health Insurance and those for Late-stage Elderly Health Insurance in Nagasaki Prefecture, Japan between April and June 2016. When two or more claim forms were issued for a patient in a single month, we combined the data and identified the number of prescribed drugs for each person. The definition of polypharmacy is a the prescription of six or more drugs per month. We investigated the prevalence of polypharmacy among the beneficiaries of the two insurance systems. Of the 605,406 beneficiaries of the 2 insurance systems, 121,033 (20.0%) patients with polypharmacy were identified. The prevalence of polypharmacy increased with age, especially among the beneficiaries aged > 85 years, with about half of the beneficiaries having polypharmacy status. About half of the people aged > 85 years in the database had polypharmacy status. When a drug is prescribed to an elderly individual, it is necessary to consider the possibility of polypharmacy-related problems.
en-copyright=
kn-copyright=

en-aut-name=AmanoHoichi
en-aut-sei=Amano
en-aut-mei=Hoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujimotoKenichi
en-aut-sei=Fujimoto
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujimoriMakoto
en-aut-sei=Fujimori
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SakaNatsumi
en-aut-sei=Saka
en-aut-mei=Natsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NomuraKyoko
en-aut-sei=Nomura
en-aut-mei=Kyoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TaniharaShinichi
en-aut-sei=Tanihara
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Public Health, Teikyo University
kn-affil=

affil-num=2
en-affil=Graduate School of Public Health, Teikyo University
kn-affil=

affil-num=3
en-affil=Graduate School of Public Health, Teikyo University
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Teikyo University School of Medicine
kn-affil=

affil-num=5
en-affil=Graduate School of Public Health, Teikyo University
kn-affil=

affil-num=6
en-affil=Graduate School of Public Health, Teikyo University
kn-affil=
en-keyword=health insurance claims
kn-keyword=health insurance claims
en-keyword=late-stage elderly health insurance
kn-keyword=late-stage elderly health insurance
en-keyword=national health insurance
kn-keyword=national health insurance
en-keyword=Japan
kn-keyword=Japan
en-keyword=polypharmacy
kn-keyword=polypharmacy
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=6
article-no=
start-page=533
end-page=536
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Reconstruction of Complete Peroneus Longus and Brevis Tendon Ruptures Using a Semitendinosus and Gracilis Tendon Graft
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The patient was a 40-year-old female who had been treated at our hospital for left peroneal tendonitis due to an ankle sprain 2 years earlier. She re-injured that ankle while dancing. The pain in the lateral left foot soon improved, but she had difficulty standing with the left foot in equinus. Complete peroneus longus and brevis tendon ruptures were diagnosed. The ipsilateral semitendinosus and gracilis tendons were harvested and used to reconstruct the tendons. Three months after surgery, the patient was able to stand in equinus, and at 5 months after surgery she resumed her original level of sports activities.
en-copyright=
kn-copyright=

en-aut-name=MorimotoYusuke
en-aut-sei=Morimoto
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TokuhashiYasuaki
en-aut-sei=Tokuhashi
en-aut-mei=Yasuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Orthopedic Surgery, Nihon University School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Orthopedic Surgery, Nihon University School of Medicine
kn-affil=
en-keyword=peroneus longus and brevis
kn-keyword=peroneus longus and brevis
en-keyword=complete rupture
kn-keyword=complete rupture
en-keyword=reconstruction
kn-keyword=reconstruction
en-keyword=hamstring tendon
kn-keyword=hamstring tendon
en-keyword=tendon grafting
kn-keyword=tendon grafting
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=6
article-no=
start-page=523
end-page=528
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Bilateral Anterior Cruciate Ligament Tear Combined with Medial Meniscus Posterior Root Tear
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The case of an individual with a bilateral anterior cruciate ligament (ACL) tear combined with a medial meniscus (MM) posterior root tear is described. A 34-year-old Japanese man with bilateral ACL rupture that occurred > 10 years earlier was diagnosed with bilateral ACL tear combined with MM posterior root tear (MMPRT). We performed a transtibial pullout repair of the MMPRT with ACL reconstruction. The tibial tunnels for the MM posterior root repair and ACL reconstruction were created separately. Postoperatively, a good clinical outcome and meniscal healing were obtained. Our surgical technique may thus contribute to anatomical MM posterior root repair and ACL reconstruction.
en-copyright=
kn-copyright=

en-aut-name=HiranakaTakaaki
en-aut-sei=Hiranaka
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkazakiYoshiki
en-aut-sei=Okazaki
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KamatsukiYusuke
en-aut-sei=Kamatsuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MasudaShin
en-aut-sei=Masuda
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakihiraShota
en-aut-sei=Takihira
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MiyazawaShinichi
en-aut-sei=Miyazawa
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of  Intelligent Orthopaedic System Development,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of  Musculoskeletal Traumatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Orthopaedic Surgery,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=bilateral anterior cruciate ligament tear
kn-keyword=bilateral anterior cruciate ligament tear
en-keyword=medial meniscus posterior root tear
kn-keyword=medial meniscus posterior root tear
en-keyword=pullout repair
kn-keyword=pullout repair
en-keyword=case report
kn-keyword=case report
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=6
article-no=
start-page=503
end-page=510
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Early Arthroscopic Pullout Repair of Medial Meniscus Posterior Root Tear Is More Effective for Reducing Medial Meniscus Extrusion
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Clinical studies have demonstrated that transtibial pullout repair led to favorable midterm outcomes in patients with medial meniscus posterior root tears (MMPRTs) although medial meniscal extrusion (MME) continued to be present. It has been unclear whether these residual postoperative MMEs existed after the pullout repair or had progressed at the very short-term evaluation after surgery. We sought to determine which characteristics of patients with MMPRTs influence the incidence of postoperative MME. The cases of 23 patients whose date of injury was known were analyzed. All patients underwent MMPRT pullout fixation. Preoperative and 3-month postoperative magnetic resonance imaging (MRI) examinations were performed. MME was retrospectively assessed on the mid-coronal plane of MRI scans. The preoperative and postoperative MME values were 4.2±1.2 mm and 4.3±1.5 mm, respectively (p=0.559). Pullout repair surgery was performed significantly earlier after the MMPRT-specific injury in patients whose postoperative MME improved compared to the patients whose MME did not improve (p<0.001). Our findings demonstrated that an early transtibial pullout repair of an MMPRT was more effective in reducing MME than a late repair. Surgeons should not miss the optimal timing for the pullout repair of an MMPRT, considering the period from the injury and the preoperative MME.
en-copyright=
kn-copyright=

en-aut-name=KamatsukiYusuke
en-aut-sei=Kamatsuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyazawaShinichi
en-aut-sei=Miyazawa
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KodamaYuya
en-aut-sei=Kodama
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HinoTomohito
en-aut-sei=Hino
en-aut-mei=Tomohito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkazakiYoshiki
en-aut-sei=Okazaki
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MasudaShin
en-aut-sei=Masuda
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NodaTomoyuki
en-aut-sei=Noda
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamakawaYasuaki
en-aut-sei=Yamakawa
en-aut-mei=Yasuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TetsunagaTomoko
en-aut-sei=Tetsunaga
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of  Intelligent Orthopaedic System, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of  Musculoskeletal traumatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of  Emergency Healthcare and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=medial meniscus
kn-keyword=medial meniscus
en-keyword=posterior root tear
kn-keyword=posterior root tear
en-keyword=pullout repair
kn-keyword=pullout repair
en-keyword=medial meniscus extrusion
kn-keyword=medial meniscus extrusion
en-keyword=magnetic resonance imaging
kn-keyword=magnetic resonance imaging
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=6
article-no=
start-page=495
end-page=501
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Transtibial Pullout Repair Reduces Posterior Extrusion of the Medial Meniscus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Medial meniscus posterior root tear causes rapid knee cartilage degradation by inducing posteromedial displacement of the medial meniscus. We evaluated medial meniscus posterior extrusion before and after pullout repair for medial meniscus posterior root tear using magnetic resonance images. Twenty-eight patients with symptomatic medial meniscus posterior root tear were included. The inclusion criteria were: acute (< 3 months) or chronic (≥3 months) medial meniscus posterior root tear after painful popping events. The exclusion criteria were: other meniscus and anterior cruciate ligament injuries. We measured medial meniscus posterior extrusion and medial meniscus anteroposterior interval at knee flexion angles of 10° and 90° preoperatively and at 3 months postoperatively. The posterior extrusion at 90° knee flexion decreased from 4.42±1.38 mm preoperatively to 3.09±1.06 mm (p<0.001) postoperatively, while at 10° knee flexion it was −4.17±1.63 mm preoperatively and −3.77±1.72mm postoperatively, showing no significant change. The anteroposterior interval at 10° knee flexion increased from 19.74±4.27 mm preoperatively to 22.15±5.10 mm postoperatively (p<0.001); at 90° knee flexion, it increased from 16.81±4.51 mm preoperatively to 19.20±4.30 mm postoperatively (p<0.001). Medial meniscus posterior extrusion and movement decreased after pullout repair. Pullout repair for medial meniscus posterior root tear improves medial meniscus posterior extrusion, especially at 90° knee flexion.
en-copyright=
kn-copyright=

en-aut-name=MasudaShin
en-aut-sei=Masuda
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkazakiYoshiki
en-aut-sei=Okazaki
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KamatsukiYusuke
en-aut-sei=Kamatsuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KodamaYuya
en-aut-sei=Kodama
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HiranakaTakaaki
en-aut-sei=Hiranaka
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=medial meniscus posterior root tear
kn-keyword=medial meniscus posterior root tear
en-keyword=pullout repair
kn-keyword=pullout repair
en-keyword=extrusion
kn-keyword=extrusion
en-keyword=open magnetic resonance imaging
kn-keyword=open magnetic resonance imaging
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=6
article-no=
start-page=475
end-page=477
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Aging Population and Research into Treatments for Abdominal Aortic Aneurysms
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Abdominal aortic aneurysms (AAAs) usually expand asymptomatically until the occurrence of a life-threatening event such as aortic rupture, which is closely associated with high mortality. AAA and aortic dissection are ranked among the top 10 causes of death in Japan. The major risk factors for AAA are age over 65 years, male gender, family history, and smoking. Thus, for prevention, smoking cessation is the most important lifestyle-intervention. For treatment, since AAA generally affects elderly people, less invasive treatment is preferable. However, the only established treatment for AAA is open repair and endovascular repair. This review describes potential medical treatments to slow aneurysm growth or prevent AAA rupture.
en-copyright=
kn-copyright=

en-aut-name=UmebayashiRyoko
en-aut-sei=Umebayashi
en-aut-mei=Ryoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UchidaHaruhito A.
en-aut-sei=Uchida
en-aut-mei=Haruhito A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WadaJunzo
en-aut-sei=Wada
en-aut-mei=Junzo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=abdominal aortic aneurysms
kn-keyword=abdominal aortic aneurysms
en-keyword=medical treatment
kn-keyword=medical treatment
en-keyword=anti-platelet drugs
kn-keyword=anti-platelet drugs
END

start-ver=1.4
cd-journal=joma
no-vol=484
cd-vols=
no-issue=
article-no=
start-page=394
end-page=401
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Syntheses and crystal structures of neodymium(III) and europium(III) complexes bearing dimethyl-, pyrrolidine-, or S-prolinol- dithiocarbamato ligands and their natural and magnetic circular dichroism spectra
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A series of Nd-III and Eu-III complexes containing achiral or chiral dithiocarbamato (dtc) ligands, [Ln(Xdtc)(3)(NN)] {Ln = Nd or Eu; X = dimethyl- (Me-2), pyrrolidine- (pyr), or (S)-prolinol- (S-proOH); NN = 1,10-phenanthroline (phen) or 2,2'-bipyridine (bpy)}, were prepared and their crystal structures and spectroscopic properties, in particular the natural circular dichroism (CD) and magnetic circular dichroism (MCD), were investigated. The crystal structures of the complexes analyzed by the X-ray diffraction method showed an 8-coordinate geometry around the Ln III center with comparable structural parameters to one another and to the related complexes reported previously. These complexes exhibited similar spectral patterns in their absorption, natural CD and MCD spectra in solution. Weak but characteristic sharp f-f transition bands were observed in the absorption and MCD spectra, but no CD signals associated with these transitions were observed even in the S-proOHdtc complexes. The MCD spectral pattern of the Eu-III complexes revealed a local C-2v symmetry around the Ln(III) center in solution, in contrast to the aqua and the analogous beta-diketonato Eu-III complexes.
en-copyright=
kn-copyright=

en-aut-name=YakubuAbdallah
en-aut-sei=Yakubu
en-aut-mei=Abdallah
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SuzukiTakayoshi
en-aut-sei=Suzuki
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KitaMasakazu
en-aut-sei=Kita
en-aut-mei=Masakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Faculty of Education, Okayama University
kn-affil=
en-keyword=Dithiocarbamate
kn-keyword=Dithiocarbamate
en-keyword=Lanthanoid
kn-keyword=Lanthanoid
en-keyword=Crystal structures
kn-keyword=Crystal structures
en-keyword=Magnetic circular dichroism
kn-keyword=Magnetic circular dichroism
en-keyword=(S)-prolinol dithiocarbamate
kn-keyword=(S)-prolinol dithiocarbamate
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4
article-no=
start-page=285
end-page=297
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Dynamic Reorganization of Microtubule and Glioma Invasion
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
en-copyright=
kn-copyright=

en-aut-name=OtaniYoshihiro
en-aut-sei=Otani
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IchikawaTomotsugu
en-aut-sei=Ichikawa
en-aut-mei=Tomotsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KurozumiKazuhiko
en-aut-sei=Kurozumi
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Neurosurgery, The University of Texas Health Science Center at Houston
kn-affil=

affil-num=2
en-affil=Department of Neurosurgery, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=3
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=glioma
kn-keyword=glioma
en-keyword=cytoskeletons
kn-keyword=cytoskeletons
en-keyword=invasion
kn-keyword=invasion
en-keyword=microtubules
kn-keyword=microtubules
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=3
article-no=
start-page=229
end-page=233
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Lights-out Surgery for Strabismus Using a Heads-Up 3D Vision System
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= During strabismus surgery using illumination from a light source, patients complain of photophobia. The NGENUITYⓇ (Alcon) system is equipped with a high-dynamic-range (HDR) camera. A 4K display viewed by wearing circularly polarized glasses provides clear three-dimensional images of the operative field. A light source is usually required for surgeries of the anterior segment (including strabismic surgery), but the digital processing function of the NGENUITYⓇ system allows image display in relatively dark regions even without a light source. We devised a novel ‘lights-out’ surgery that does not use a microscope’s light source, and we examined the usefulness of this technique in 2 cases of strabismic surgery. We performed strabismus surgery using the NGENUITYⓇ system in two patients between January and June 2018. The HDR function was used, and the aperture was opened to the maximum while the gain was adjusted. Surgery was conducted without using the microscope’s light source. We report the 2 cases’ results and evaluate the novel method. The surgeries were performed without problem even though the microscope’s light source was not used. The patients’ photophobia was alleviated. Lights-out surgery is a potentially useful modality for strabismus surgery.
en-copyright=
kn-copyright=

en-aut-name=HamasakiIchiro
en-aut-sei=Hamasaki
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShibataKiyo
en-aut-sei=Shibata
en-aut-mei=Kiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShimizuTakehiro
en-aut-sei=Shimizu
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KonoReika
en-aut-sei=Kono
en-aut-mei=Reika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShiragaFumio
en-aut-sei=Shiraga
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=
en-keyword=head-up surgery
kn-keyword=head-up surgery
en-keyword=3D vision system
kn-keyword=3D vision system
en-keyword=high dynamic range
kn-keyword=high dynamic range
en-keyword=video enhancement
kn-keyword=video enhancement
en-keyword=strabismus surgery
kn-keyword=strabismus surgery
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=2
article-no=
start-page=101
end-page=107
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Factors Affecting the Absorption of Midazolam to the Extracorporeal Membrane Oxygenation Circuit
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits.
en-copyright=
kn-copyright=

en-aut-name=IidaAtsuyoshi
en-aut-sei=Iida
en-aut-mei=Atsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ZamamiYoshito
en-aut-sei=Zamami
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamadaAkane
en-aut-sei=Yamada
en-aut-mei=Akane
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KogaTadashi
en-aut-sei=Koga
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ImaiToru
en-aut-sei=Imai
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IchibaShingo
en-aut-sei=Ichiba
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Emergency and Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency and Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Human Ecology, Okayama University Graduate School of Environmental and Life Science
kn-affil=

affil-num=4
en-affil=Department of Clinical Pharmacy, Institute of Biomedical Sciences, Tokushima University Graduate School
kn-affil=

affil-num=5
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
kn-affil=

affil-num=7
en-affil=Department of Pharmacy, Nihon University Itabashi Hospital
kn-affil=

affil-num=8
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Emergency and Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Surgical Intensive Care Medicine, Nippon Medical School Hospital
kn-affil=
en-keyword=sedatives
kn-keyword=sedatives
en-keyword=ECMO
kn-keyword=ECMO
en-keyword=polyvinyl chloride
kn-keyword=polyvinyl chloride
en-keyword=pharmacokinetics
kn-keyword=pharmacokinetics
en-keyword=pharmacodynamics
kn-keyword=pharmacodynamics
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=1
article-no=
start-page=15
end-page=20
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=High-flow Nasal Cannula Versus Noninvasive ventilation for Postextubation Acute Respiratory Failure after Pediatric Cardiac Surgery
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We compared the reintubation rate in children who received high-flow nasal cannula (HFNC) therapy to the rate in children who received noninvasive ventilation (NIV) therapy for acute respiratory failure (ARF) after cardiac surgery. This was a retrospective analysis of 35 children who received HFNC therapy for ARF after cardiac surgery in 2014-2015 (the HFNC group). We selected 35 children who had received NIV therapy for ARF after cardiac surgery in 2009-2012 as a control group. The matching parameters were body weight and risk adjustment for congenital heart surgery category 1. The reintubation rate within 48 h in the HFNC group tended to be lower than that in the NIV group (3% vs. 17%, p=0.06). The reintubation rate within 28 days was significantly lower in the HFNC group compared to the NIV group (3% vs. 26%, p=0.04). The HFNC group’s ICU stays were significantly shorter than those of the NIV group: 10 (IQR: 7-17) days vs. 17 (11-32) days, p=0.009. HFNC therapy might be associated with a reduced reintubation rate in children with ARF after cardiac surgery.
en-copyright=
kn-copyright=

en-aut-name=ShiojiNaohiro
en-aut-sei=Shioji
en-aut-mei=Naohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KanazawaTomoyuki
en-aut-sei=Kanazawa
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IwasakiTatsuo
en-aut-sei=Iwasaki
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShimizuKazuyoshi
en-aut-sei=Shimizu
en-aut-mei=Kazuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SuemoriTomohiko
en-aut-sei=Suemori
en-aut-mei=Tomohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KuroeYasutoshi
en-aut-sei=Kuroe
en-aut-mei=Yasutoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=
en-keyword=high-flow nasal cannula
kn-keyword=high-flow nasal cannula
en-keyword=noninvasive ventilation
kn-keyword=noninvasive ventilation
en-keyword=reintubation
kn-keyword=reintubation
en-keyword=congenital heart disease
kn-keyword=congenital heart disease
en-keyword=acute respiratory failure
kn-keyword=acute respiratory failure
END

start-ver=1.4
cd-journal=joma
no-vol=44
cd-vols=
no-issue=4
article-no=
start-page=449
end-page=454
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201704
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Usefulness of serum 5-S-cysteinyl-dopa as a biomarker for predicting prognosis and detecting relapse in patients with advanced stage malignant melanoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= With the recent development of novel molecular targeted drugs for advanced stage malignant melanoma (MM), including RAF and mitogen-activated protein kinase kinase inhibitors and immune checkpoint blockers, the early detection of relapse is important for managing patients with MM. In this study, we retrospectively analyzed two conventional serum biomarkers, 5-S-cysteinyl-dopa and lactate dehydrogenase, in patients with MM (n = 140) who were treated at a single Japanese institute from June 2007 to June 2015. At the initial hospital visit, serum 5-S-cysteinyl-dopa levels were significantly increased in patients with stages III (n = 38) and IV (n = 20) MM compared with patients with stages 0-II (n = 62) MM. In addition, in patients with stages III and IV MM, serum 5-S-cysteinyl-dopa levels of more than 15.0 nmol/L at initial hospital visit correlated with a poor prognosis. In 11 of 14 patients whose disease progressed during follow up (mostly from stages III-IV), serum 5-S-cysteinyl-dopa levels exceeded the normal limit of 10.0 nmol/L during the clinical detection of distant metastases. These results indicate the usefulness of measuring serum 5-S-cysteinyl-dopa levels at initial hospital visit and during follow up for early and effective therapeutic interventions using newly developed molecular targeted drugs.
en-copyright=
kn-copyright=

en-aut-name=HiroshiUmemura
en-aut-sei=Hiroshi
en-aut-mei=Umemura
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamasakiOsamu
en-aut-sei=Yamasaki
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KajiTatsuya
en-aut-sei=Kaji
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OtsukaMasaki
en-aut-sei=Otsuka
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AsagoeKenji
en-aut-sei=Asagoe
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakataMinoru
en-aut-sei=Takata
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IwatsukiKeiji
en-aut-sei=Iwatsuki
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Division of Dermatology, Shizuoka Cancer Center Hospital
kn-affil=

affil-num=5
en-affil=Department of Dermatology, National Hospital Organization Okayama Medical Center
kn-affil=

affil-num=6
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=5-S-cysteinyl-dopa
kn-keyword=5-S-cysteinyl-dopa
en-keyword=biomarker
kn-keyword=biomarker
en-keyword=lactate dehydrogenase
kn-keyword=lactate dehydrogenase
en-keyword=malignant melanoma
kn-keyword=malignant melanoma
en-keyword=serum 5-S-CD
kn-keyword=serum 5-S-CD
END

start-ver=1.4
cd-journal=joma
no-vol=129
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=44
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170403
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Thoracoscopic esophagectomy was effective in a case of lower esophageal stenosis due to recurrence of achalasia after myotomy 40 years previously
kn-title=40年経過した食道アカラシア術後の食道拡張・下部食道狭窄症に 対して胸腔鏡下食道亜全摘が著効した1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= When planning surgery for achalasia, it is important to plan for adequate myotomy and prevention of reflux. However, achalasia may recur if the procedure was inadequate or in patients with a long-term course. The present case is a 68-year-old woman who underwent myotomy of the lower esophageal sphincter 40 years ago, but recently reported difficulty in swallowing. Dilatation of the thoracic esophagus and stenosis of the abdominal esophagus were identified by examination, and the patient was diagnosed with recurrence of achalasia. After percutaneous endoscopic gastrostomy was performed to recover nutritional status, thoracoscopic esophagectomy was carried out. The patient'spost-operative course was uneventful and oral intake was enabled. At the time of writing, there has been no re-recurrence. There is no standard therapy for post-operative recurrence of achalasia. We believe that thoracoscopic esophagectomy for the recurrence of achalasia is a safe and minimally invasive alternative to conventional surgery.
en-copyright=
kn-copyright=

en-aut-name=KatsuraYuki
en-aut-sei=Katsura
en-aut-mei=Yuki
kn-aut-name=桂佑貴
kn-aut-sei=桂
kn-aut-mei=佑貴
aut-affil-num=1
ORCID=

en-aut-name=ShirakawaYasuhiro
en-aut-sei=Shirakawa
en-aut-mei=Yasuhiro
kn-aut-name=白川靖博
kn-aut-sei=白川
kn-aut-mei=靖博
aut-affil-num=2
ORCID=

en-aut-name=TanabeShunsuke
en-aut-sei=Tanabe
en-aut-mei=Shunsuke
kn-aut-name=田邊俊介
kn-aut-sei=田邊
kn-aut-mei=俊介
aut-affil-num=3
ORCID=

en-aut-name=MaedaNaomi
en-aut-sei=Maeda
en-aut-mei=Naomi
kn-aut-name=前田直見
kn-aut-sei=前田
kn-aut-mei=直見
aut-affil-num=4
ORCID=

en-aut-name=NomaKazuhiro
en-aut-sei=Noma
en-aut-mei=Kazuhiro
kn-aut-name=野間和広
kn-aut-sei=野間
kn-aut-mei=和広
aut-affil-num=5
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Hospital
kn-affil=岡山大学病院　消化管外科

affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Hospital
kn-affil=岡山大学病院　消化管外科

affil-num=3
en-affil=Department of Gastroenterological Surgery, Okayama University Hospital
kn-affil=岡山大学病院　消化管外科

affil-num=4
en-affil=Department of Gastroenterological Surgery, Okayama University Hospital
kn-affil=岡山大学病院　消化管外科

affil-num=5
en-affil=Department of Gastroenterological Surgery, Okayama University Hospital
kn-affil=岡山大学病院　消化管外科

affil-num=6
en-affil=Department of Gastroenterological Surgery, Okayama University Hospital
kn-affil=岡山大学病院　消化管外科
en-keyword=食道アカラシア (achalasia)
kn-keyword=食道アカラシア (achalasia)
en-keyword=再手術 (reoperation)
kn-keyword=再手術 (reoperation)
en-keyword=食道亜全摘 (esophagectomy)
kn-keyword=食道亜全摘 (esophagectomy)
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=1
article-no=
start-page=21
end-page=25
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of mucinous adenocarcinoma of the duodenum and literature review of 16 cases reported in Japan
kn-title=原発性十二指腸粘液癌の一例― 本邦報告16例の検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Primary mucinous adenocarcinoma of the duodenum is rare. Here we report a case we recently encountered, and we review 16 cases reported in Japan. An 82-year-old Japanese woman was admitted to our hospital complaining of abdominal pain and heartburn. An endoscopic examination revealed a Type 2 tumor in the descending limb of the duodenum, and endoscopically obtained specimens revealed a poorly differentiated adenocarcinoma. We performed a curative pancreatoduodenectomy with lymph node resection, and the surgical specimen revealed that the duodenum was the primary site of the mucinous adenocarcinoma. The patient is currently alive ＞ 1 year after the operation without any evidence of recurrence. Of the 16 patients reviewed, all patients had advanced tumors those depth were T3-T4. 9 patients had lymph node metastasis and 4 patients had peritoneal dissemination at the time of surgery. Since mucinous adenocarcinoma of the duodenum is often progressive cancer at a diagnosis, which is tend to have a worse prognosis than other histological types.
en-copyright=
kn-copyright=

en-aut-name=HamanoIkumi
en-aut-sei=Hamano
en-aut-mei=Ikumi
kn-aut-name=浜野郁美
kn-aut-sei=浜野
kn-aut-mei=郁美
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoYusuke
en-aut-sei=Matsumoto
en-aut-mei=Yusuke
kn-aut-name=松本祐介
kn-aut-sei=松本
kn-aut-mei=祐介
aut-affil-num=2
ORCID=

en-aut-name=EndoYoshikatsu
en-aut-sei=Endo
en-aut-mei=Yoshikatsu
kn-aut-name=遠藤芳克
kn-aut-sei=遠藤
kn-aut-mei=芳克
aut-affil-num=3
ORCID=

en-aut-name=WatanabeNaoki
en-aut-sei=Watanabe
en-aut-mei=Naoki
kn-aut-name=渡邊直樹
kn-aut-sei=渡邊
kn-aut-mei=直樹
aut-affil-num=4
ORCID=

en-aut-name=KaiKyouhei
en-aut-sei=Kai
en-aut-mei=Kyouhei
kn-aut-name=甲斐恭平
kn-aut-sei=甲斐
kn-aut-mei=恭平
aut-affil-num=5
ORCID=

en-aut-name=SatoShizou
en-aut-sei=Sato
en-aut-mei=Shizou
kn-aut-name=佐藤四三
kn-aut-sei=佐藤
kn-aut-mei=四三
aut-affil-num=6
ORCID=

en-aut-name=WaniYoji
en-aut-sei=Wani
en-aut-mei=Yoji
kn-aut-name=和仁洋治
kn-aut-sei=和仁
kn-aut-mei=洋治
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=2
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=3
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=4
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=5
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=6
en-affil=
kn-affil=姫路赤十字病院　外科

affil-num=7
en-affil=
kn-affil=姫路赤十字病院　病理診断科
en-keyword=原発性十二指腸癌（primary duodenal cancer）
kn-keyword=原発性十二指腸癌（primary duodenal cancer）
en-keyword=粘液癌（mucinous carcinoma）
kn-keyword=粘液癌（mucinous carcinoma）
en-keyword=膵頭十二指腸切除（pancreatoduodenectomy）
kn-keyword=膵頭十二指腸切除（pancreatoduodenectomy）
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=3
article-no=
start-page=187
end-page=190
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20141201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2013 Incentive Award of the Okayama Medical Association in General Medical Science (2013 Yuuki Prize)
kn-title=平成25年度岡山医学会賞 総合研究奨励賞（結城賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=受賞対象論文: Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S：Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. J Natl Cancer Inst (2014) 106, djt338
en-copyright=
kn-copyright=

en-aut-name=YamamotoHiromasa
en-aut-sei=Yamamoto
en-aut-mei=Hiromasa
kn-aut-name=山本寛斉
kn-aut-sei=山本
kn-aut-mei=寛斉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　呼吸器・乳腺内分泌外科学
END

start-ver=1.4
cd-journal=joma
no-vol=44
cd-vols=
no-issue=9
article-no=
start-page=1927
end-page=1936
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=201309
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Distinct morphologic, phenotypic, and clinical-course characteristics of indolent peripheral T-cell lymphoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) consists of a heterogeneous group of lymphomas. Patients. generally show an aggressive clinical course and very poor outcome. Although the 2008 World Health Organization classification of PTCL-NOS includes 3 variants, low-grade lymphoma is not Included. Of 277 PTCL-NOS cases recorded in our consultation files, we examined the clinicopathologic characteristics of 10 patients with T-cell lymphomas composed of small-sized cells with slight nuclear atypia. Eight patients showed extranodal involvement (5 patients, spleen; 3 patients, thyroid), and 5 patients were at clinical stage I or II. Histologically, all samples presented diffuse infiltrate of small lymphoid cells, with few mitotic figures. Immunohistologically, all samples were positive for CD3, and CD:20 Was detected in 5 samples. All samples showed a low Ki-67 labeling index (mean, 1.05%), and 7 samples were positive for central memory T-cell markers. Clonal T-cell receptor gamma chain and/or alpha-beta chain gene rearrangements were detected in all 10 patients. Five patients received chemotherapy, whereas for 3 patients, treatment consisted only of observation following surgical resection of the spleen or thyroid. Nine patients were alive at a median follow-up time of 19.5 months, whereas 1 patient died of an unrelated disease. The present study strongly indicates that T-cell lymphoma with small-sized lymphoma cells and a low Ki-67 labeling index is a distinct variant. Recognition of this novel lymphoma subtype, which should not be defined merely as PTCL-NOS, should be seriously considered.
en-copyright=
kn-copyright=

en-aut-name=HayashiEiko
en-aut-sei=Hayashi
en-aut-mei=Eiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakataKatsuyoshi
en-aut-sei=Takata
en-aut-mei=Katsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatoYasuharu
en-aut-sei=Sato
en-aut-mei=Yasuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TashiroYukie
en-aut-sei=Tashiro
en-aut-mei=Yukie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TachiyamaYoshiro
en-aut-sei=Tachiyama
en-aut-mei=Yoshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Sawada-KitamuraSeiko
en-aut-sei=Sawada-Kitamura
en-aut-mei=Seiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HiramatsuYasushi
en-aut-sei=Hiramatsu
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SugiguchiShun
en-aut-sei=Sugiguchi
en-aut-mei=Shun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NoseSoichiro
en-aut-sei=Nose
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HirokawaMitsuyoshi
en-aut-sei=Hirokawa
en-aut-mei=Mitsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AndoMidori
en-aut-sei=Ando
en-aut-mei=Midori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=Abd MaderLamia
en-aut-sei=Abd Mader
en-aut-mei=Lamia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=YoshinoTadashi
en-aut-sei=Yoshino
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol

affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol

affil-num=4
en-affil=
kn-affil=Imakiire Gen Hosp, Dept Pathol

affil-num=5
en-affil=
kn-affil=Hiroshima Nishi Med Ctr, Div Pathol

affil-num=6
en-affil=
kn-affil=Kanazawa Univ Hosp, Div Pathol

affil-num=7
en-affil=
kn-affil=Himeji Red Cross Hosp, Dept Hematol & Oncol

affil-num=8
en-affil=
kn-affil=Tonami Gen Hosp, Dept Pathol

affil-num=9
en-affil=
kn-affil=Okayama Saiseikai Gen Hosp, Dept Pathol

affil-num=10
en-affil=
kn-affil=Kuma Hosp, Dept Diagnost Pathol

affil-num=11
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol

affil-num=12
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol

affil-num=13
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol

affil-num=14
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol

affil-num=15
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
en-keyword=Indolent PTCL
kn-keyword=Indolent PTCL
en-keyword=CD20
kn-keyword=CD20
en-keyword=Ki-67
kn-keyword=Ki-67
en-keyword=Memory T cell
kn-keyword=Memory T cell
en-keyword=Good prognosis
kn-keyword=Good prognosis
END

start-ver=1.4
cd-journal=joma
no-vol=55
cd-vols=
no-issue=3
article-no=
start-page=161
end-page=176
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Chemical investigation on inorganic constituents in night soil (excreta) II. On the amounts of Ca, Mg, Na, K, P, Cl, S, Mn, Fe, Cd, Cu, Zn, Ni and Pb in the night soil of inhabitants of the Tohoku district
kn-title=し尿中の無機成分に関する研究 (第2報) 東北地方のし尿中のCa, Mg, Na, K, P, Cl, S, Mn, Fe, Cd, Cu, Zn, Ni, Pbの含有量について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KobayashiJ.
en-aut-sei=Kobayashi
en-aut-mei=J.
kn-aut-name=小林純
kn-aut-sei=小林
kn-aut-mei=純
aut-affil-num=1
ORCID=

en-aut-name=MoriiF.
en-aut-sei=Morii
en-aut-mei=F.
kn-aut-name=森井ふじ
kn-aut-sei=森井
kn-aut-mei=ふじ
aut-affil-num=2
ORCID=

en-aut-name=MuramotoS.
en-aut-sei=Muramoto
en-aut-mei=S.
kn-aut-name=村本茂樹
kn-aut-sei=村本
kn-aut-mei=茂樹
aut-affil-num=3
ORCID=

en-aut-name=NakashimaS.
en-aut-sei=Nakashima
en-aut-mei=S.
kn-aut-name=中島進
kn-aut-sei=中島
kn-aut-mei=進
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=4
article-no=
start-page=157
end-page=169
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=198503
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Partitioning of heavy metals (Fe,Mn,Cd,Pb,Cu,Zn,Co,Ni and As) and P into selective chemical fractions in sediments from Lake Kojima
kn-title=児島湖湖底堆積物中の重金属元素(鉄,マンガン,カドミウム,鉛,銅,亜鉛,コバルト,ニッケル,ヒ素)およびリンの形態分別
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakashimaS.
en-aut-sei=Nakashima
en-aut-mei=S.
kn-aut-name=中島進
kn-aut-sei=中島
kn-aut-mei=進
aut-affil-num=1
ORCID=

en-aut-name=YagiM.
en-aut-sei=Yagi
en-aut-mei=M.
kn-aut-name=八木正一
kn-aut-sei=八木
kn-aut-mei=正一
aut-affil-num=2
ORCID=

en-aut-name=AoyamaI.
en-aut-sei=Aoyama
en-aut-mei=I.
kn-aut-name=青山勲
kn-aut-sei=青山
kn-aut-mei=勲
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=1
article-no=
start-page=43
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=197903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the effects of complexing agents for the toxicity mitigation and removal of heavy metals 3. Removal of metals from the Cd-accumulated carp by the exposure of complexing agents (EDTA) for short term (2 weeks)
kn-title=コンプレキサンによる重金属の毒性緩和及び除去性に関する基礎的研究 第3報 EDTA短期間暴露によるカドミウム既汚染魚からの金属除去性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MuramotoS.
en-aut-sei=Muramoto
en-aut-mei=S.
kn-aut-name=村本茂樹
kn-aut-sei=村本
kn-aut-mei=茂樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=1
article-no=
start-page=31
end-page=42
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=197903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the effects of complexing agents for the toxicity mitigation and removal of heavy metals 2. Effects of complexing agents on the toxicity of heavy metals to carp at low levels of the metals
kn-title=コンプレキサンによる重金属の毒性緩和及び除去性に関する基礎的研究 第2報 低濃度の重金属(Cd,Cu)水における水生動物へのこれら重金属の集積及び毒性に対するコンプレキサンの影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MuramotoS.
en-aut-sei=Muramoto
en-aut-mei=S.
kn-aut-name=村本茂樹
kn-aut-sei=村本
kn-aut-mei=茂樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=2
article-no=
start-page=127
end-page=142
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=197803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the effects of complexing agents for the toxicity mitigation and removal of heavy metals. I. Effects of complexing agents (NTA, EDTA, DTPA) on accumulation and toxicity of sub-and lethal levels of heavy metals (Cu, Zn, Cu, Pb) to aquatic animals
kn-title=コンプレキサンによる重金属の毒性緩和及び除去性に関する基礎的研究 第1報 重金属(Cd,Zn,Cu,Pb)の比較的高濃度水における水産動物への集積及び毒性に対するコンプレキサンの影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MuramotoS.
en-aut-sei=Muramoto
en-aut-mei=S.
kn-aut-name=村本茂樹
kn-aut-sei=村本
kn-aut-mei=茂樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=4
article-no=
start-page=215
end-page=228
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=197101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=群馬県安中市の製錬所に因る農作物などの重金属(Cd,Pb,Zn)汚染について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小林純
kn-aut-sei=小林
kn-aut-mei=純
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=森井ふじ
kn-aut-sei=森井
kn-aut-mei=ふじ
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=村本茂樹
kn-aut-sei=村本
kn-aut-mei=茂樹
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=中島進
kn-aut-sei=中島
kn-aut-mei=進
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=瀬戸圭子
kn-aut-sei=瀬戸
kn-aut-mei=圭子
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=吉本智子
kn-aut-sei=吉本
kn-aut-mei=智子
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=
kn-affil=

affil-num=6
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=8
article-no=
start-page=572
end-page=578
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We evaluated a new therapeutic strategy for malignant glioma, which combines intratumoral inoculation of mesenchymal stem cells (MSCs) expressing cytosine deaminase gene with 5-fluorocytosine (5-FC) administration. For in vitro and in vivo experiments, MSCs were transfected with adenovirus carrying either enhanced green fluorescent protein gene (AdexCAEGFP) or cytosine deaminase gene (AdexCACD), to establish MSC-expressing EGFP (MSC-EGFP) or CD (MSC-CD). Co-culture of 9L glioma cells with MSC-CD in a medium containing 5-FC resulted in a remarkable reduction in 9L cell viability. The migratory ability of MSC-EGFP toward 9L cells was demonstrated by double-chamber assay. For the in vivo study, rats harboring 9L brain tumors were inoculated with MSC-EGFP or MSC-CD. Immunohistochemistry of rat brain tumors inoculated with MSC-EGFP showed intratumoral distribution of MSC-EGFP. Survival analysis of rats bearing 9L gliomas treated with intratumoral MSC-CD and intraperitoneal 5-FC resulted in significant prolongation of survival compared with control animals. In conclusion, molecular therapy combining suicide gene therapy and MSCs as a targeting vehicle represents a potential new therapeutic approach for malignant glioma, both with respect to the antitumor potential of this system and its neuroprotective effect on normal brain tissue.
en-copyright=
kn-copyright=

en-aut-name=KosakaH
en-aut-sei=Kosaka
en-aut-mei=H
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IchikawaT
en-aut-sei=Ichikawa
en-aut-mei=T
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KurozumiK
en-aut-sei=Kurozumi
en-aut-mei=K
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KambaraH
en-aut-sei=Kambara
en-aut-mei=H
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=InoueS
en-aut-sei=Inoue
en-aut-mei=S
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MaruoT
en-aut-sei=Maruo
en-aut-mei=T
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakamuraK
en-aut-sei=Nakamura
en-aut-mei=K
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HamadaH
en-aut-sei=Hamada
en-aut-mei=H
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=DateI
en-aut-sei=Date
en-aut-mei=I
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=
kn-affil=

affil-num=6
en-affil=
kn-affil=

affil-num=7
en-affil=
kn-affil=Hokkaido Univ, Grad Sch Life Sci, Fac Adv Life Sci, Innate Immun Lab

affil-num=8
en-affil=
kn-affil=Tokyo Univ Pharm & Life Sci, Dept Life Sci

affil-num=9
en-affil=
kn-affil=
en-keyword=glioma
kn-keyword=glioma
en-keyword=mesenchymal stem cell
kn-keyword=mesenchymal stem cell
en-keyword=suicide gene
kn-keyword=suicide gene
en-keyword=bystander effect
kn-keyword=bystander effect
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=45
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of gastrointestinal stromal tumor with synchronous liver metastases showing long-term disease control by imatinib
kn-title=イマチニブが長期に奏効している同時性肝転移を伴う消化管間質腫瘍の１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Radical surgery is the primary treatment for gastrointestinal stromal tumor (GIST), so that unrsectable GIST has been considered a fatal disease, and the median duration of survival for patients with an unresectable GIST before the era of molecular targeted therapy has been about 18 months. Since the recent development of agents for molecular targeted therapy, including imatinib mesylate, the prognosis of unrsectable GIST has been dramatically improved. The B2222 trial reported that a median time to progression and a median overall survival for advanced GIST treated with imatinib of 24 months and 57 months, respectively. We recently experienced a case of gastrointestinal stromal tumor with synchronous liver metastases maintained in whom the disease was controlled for 4 years by imatinib. The patient is 37-year-old man and he took imatinib mesylate at 400mg/day with no adverse events. Both primary and metastases lesions responded well to imatinib treatment, and this efficacy has endured for 4 years, such that surgical intervention is now considered possible. While GIST is a relatively rare disease and clinical evidence is still poor, we document our considerations for the therapy in this case as well as the results.
en-copyright=
kn-copyright=

en-aut-name=UnoFutoshi
en-aut-sei=Uno
en-aut-mei=Futoshi
kn-aut-name=宇野太
kn-aut-sei=宇野
kn-aut-mei=太
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraYasuhiro
en-aut-sei=Fujiwara
en-aut-mei=Yasuhiro
kn-aut-name=藤原康宏
kn-aut-sei=藤原
kn-aut-mei=康宏
aut-affil-num=2
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=2
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
en-keyword=イマチニブ（imatinib）
kn-keyword=イマチニブ（imatinib）
en-keyword=GIST
kn-keyword=GIST
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=13
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cancer immunotherapy with blocking of immune checkpoints
kn-title=免疫チェックポイント制御とがん免疫治療
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=がんワクチンによる免疫治療では，如何にCD8T細胞を感作（プライミング）しその数を増やすか（免疫増強）という点に多大の努力が払われて来た．樹状細胞への抗原デリバリーと抗原プロセシング／提示，Toll様受容体などの刺激，即ち自然免疫系の活性化の併用などはそれに該当する．しかし十分に活性化されたＴ細胞をもってしても癌の拒絶は容易ではない．それには癌組織という特殊な環境が禍している．Ｔ細胞は癌塊内に入り込み莫大な数の癌細胞と遭遇する．癌組織内での繰り返す抗原認識の過程でＴ細胞は疲弊し，次第に本来あるべき機能を喪失していく．この疲弊（exhaustion）と呼ばれる現象は，Ｔ細胞に発現する複数の免疫抑制性分子―免疫チェックポイント分子―と腫瘍に発現するそのリガンドの結合によってもたらされる．代表的なチェックポイント分子の機能を抑制し，エフェクターＴ細胞が疲弊することなくその機能を長く維持できれば，これからのがん免疫治療に飛躍的な進展がみられるかもしれない．
en-copyright=
kn-copyright=

en-aut-name=UdonoHeiichiro
en-aut-sei=Udono
en-aut-mei=Heiichiro
kn-aut-name=鵜殿平一郎
kn-aut-sei=鵜殿
kn-aut-mei=平一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　免疫学
en-keyword=がんワクチン
kn-keyword=がんワクチン
en-keyword=CTL
kn-keyword=CTL
en-keyword=免疫チェックポイント
kn-keyword=免疫チェックポイント
en-keyword=Ｔ細胞疲弊
kn-keyword=Ｔ細胞疲弊
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=111
end-page=114
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Therapeutic effects of mesenchymal stem cell transplantation on rat models of Parkinson’s disease
kn-title=パーキンソン病モデルラットに対する間葉系幹細胞移植の治療効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WangFeifei
en-aut-sei=Wang
en-aut-mei=Feifei
kn-aut-name=王飛霏
kn-aut-sei=王
kn-aut-mei=飛霏
aut-affil-num=1
ORCID=

en-aut-name=YasuharaTakao
en-aut-sei=Yasuhara
en-aut-mei=Takao
kn-aut-name=安原隆雄
kn-aut-sei=安原
kn-aut-mei=隆雄
aut-affil-num=2
ORCID=

en-aut-name=KamedaMasahiro
en-aut-sei=Kameda
en-aut-mei=Masahiro
kn-aut-name=亀田雅博
kn-aut-sei=亀田
kn-aut-mei=雅博
aut-affil-num=3
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=伊達勲
kn-aut-sei=伊達
kn-aut-mei=勲
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=高知大学医学部　先端医療学推進センター

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学
en-keyword=Parkinson’s disease
kn-keyword=Parkinson’s disease
en-keyword=mesenchymal stem cell
kn-keyword=mesenchymal stem cell
en-keyword=SDF-1 alfa
kn-keyword=SDF-1 alfa
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=5
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice
kn-title=同種抗原による移植片対白血病効果減弱のメカニズム
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AsakuraShoji
en-aut-sei=Asakura
en-aut-mei=Shoji
kn-aut-name=朝倉昇司
kn-aut-sei=朝倉
kn-aut-mei=昇司
aut-affil-num=1
ORCID=

en-aut-name=HashimotoDaigo
en-aut-sei=Hashimoto
en-aut-mei=Daigo
kn-aut-name=橋本大吾
kn-aut-sei=橋本
kn-aut-mei=大吾
aut-affil-num=2
ORCID=

en-aut-name=TakashimaShuichiro
en-aut-sei=Takashima
en-aut-mei=Shuichiro
kn-aut-name=高嶋秀一郎
kn-aut-sei=高嶋
kn-aut-mei=秀一郎
aut-affil-num=3
ORCID=

en-aut-name=SugiyamaHaruko
en-aut-sei=Sugiyama
en-aut-mei=Haruko
kn-aut-name=杉山暖子
kn-aut-sei=杉山
kn-aut-mei=暖子
aut-affil-num=4
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=前田嘉信
kn-aut-sei=前田
kn-aut-mei=嘉信
aut-affil-num=5
ORCID=

en-aut-name=AkashiKoichi
en-aut-sei=Akashi
en-aut-mei=Koichi
kn-aut-name=赤司浩一
kn-aut-sei=赤司
kn-aut-mei=浩一
aut-affil-num=6
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=谷本光音
kn-aut-sei=谷本
kn-aut-mei=光音
aut-affil-num=7
ORCID=

en-aut-name=TeshimaTakanori
en-aut-sei=Teshima
en-aut-mei=Takanori
kn-aut-name=豊嶋崇徳
kn-aut-sei=豊嶋
kn-aut-mei=崇徳
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=国立病院機構岡山医療センター　血液内科

affil-num=2
en-affil=
kn-affil=岡山大学病院　血液・腫瘍内科

affil-num=3
en-affil=
kn-affil=九州大学大学院　病態修復内科学

affil-num=4
en-affil=
kn-affil=岡山大学病院　血液・腫瘍内科

affil-num=5
en-affil=
kn-affil=岡山大学病院　血液・腫瘍内科

affil-num=6
en-affil=
kn-affil=九州大学病院　遺伝子細胞療法部

affil-num=7
en-affil=
kn-affil=岡山大学病院　血液・腫瘍内科

affil-num=8
en-affil=
kn-affil=九州大学病院　遺伝子細胞療法部
en-keyword=同種造血幹細胞移植
kn-keyword=同種造血幹細胞移植
en-keyword=移植片対白血病効果
kn-keyword=移植片対白血病効果
en-keyword=programmed death-1 (PD-1)
kn-keyword=programmed death-1 (PD-1)
en-keyword=programmed death ligand-1 (PD-L1)
kn-keyword=programmed death ligand-1 (PD-L1)
END

start-ver=1.4
cd-journal=joma
no-vol=123
cd-vols=
no-issue=2
article-no=
start-page=129
end-page=132
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Laparoscopic surgery for mesenteric Castleman's disease
kn-title=腹腔鏡下に摘出しえた上行結腸間膜発生のCastleman病の１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report herein a case of mesenteric Castleman's disease which was confirmed on pathology. A 60-year-old man was admitted to our hospital complaining of abdominal pain. On the physical examination, there was no palpable mass. Computed tomography findings and magnetic resonance imaging revealed a well circumscribed, lobulated round mass on the right side of the superior mesenteric vein. Laparoscopic surgery for the mesenteric tumor was carried out to obtain a definite diagnosis and treatment. In the operative field, the mass was located on the ascending colic mesentery and measured about 3 cm in size. It was solid and surrounded by a thin fibrous capsule. The histological diagnosis of the mesenteric tumor was hyaline vascular type Castleman's disease. The postoperative course of the patient was uneventful, and he was discharged on the 10th postoperative day.
en-copyright=
kn-copyright=

en-aut-name=NishieManabu
en-aut-sei=Nishie
en-aut-mei=Manabu
kn-aut-name=西江学
kn-aut-sei=西江
kn-aut-mei=学
aut-affil-num=1
ORCID=

en-aut-name=OtsukaShinya
en-aut-sei=Otsuka
en-aut-mei=Shinya
kn-aut-name=大塚真哉
kn-aut-sei=大塚
kn-aut-mei=真哉
aut-affil-num=2
ORCID=

en-aut-name=TomodaJun
en-aut-sei=Tomoda
en-aut-mei=Jun
kn-aut-name=友田純
kn-aut-sei=友田
kn-aut-mei=純
aut-affil-num=3
ORCID=

en-aut-name=FujiwaraKeishi
en-aut-sei=Fujiwara
en-aut-mei=Keishi
kn-aut-name=藤原敬士
kn-aut-sei=藤原
kn-aut-mei=敬士
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=2
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=3
en-affil=
kn-affil=国立病院機構福山医療センター　内科

affil-num=4
en-affil=
kn-affil=光生病院　内科
en-keyword=結腸間膜 (mesocolon)
kn-keyword=結腸間膜 (mesocolon)
en-keyword=Castleman病 (Castleman's disease)
kn-keyword=Castleman病 (Castleman's disease)
en-keyword=腹腔鏡手術 (laparoscopic surgery)
kn-keyword=腹腔鏡手術 (laparoscopic surgery)
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=1
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1951
dt-pub=195108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=CHROMATOGRAPHIC ANALYSIS OF METALS BY ORGANIC REAGENTS (Ist Report)
kn-title=有機試藥による金属クロマトグラフ分析法とその応用（第1法）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The principle of this method is to combine the metals with organic reagents, then extract them with non-polar solvents, and determine them by making chromatograph with adequate adsorbents. Dithizone is used to determine Hg, Cd, Bi, Ag, Cu, Zn, Ni, Co, Tl, Pb, Pd and its isotopes, Pt group, Au, etc. Diphenylcarbazone is applicable to determine Hg, Cu, Zn, Ni, etc. Xanthate is useful to determine Mo, Cu, Ni, Co, etc. α-orβ- Nitrosoβ- orα-naphthol is used to determine Fe, Co, earth acids etc. Diethyldithiocarbamate is used to determine Mo, Cu, Ni, Co, Fe, etc. Oxine series are useful to determine Cu, Ni, Fe, V, rare earth etc. α-indolcarbonic acid is applied to determine Fe, Co, rare earth etc. Acethyl acetone is used to determine Th, Fe, etc. Some other organic reagents were used moreover. There are some elements of which necessary condition for quantitative determination is still not decided or the order of adsorption is indefmite. As adsorbents alkaline, neutral or acid alumina, diatom earth and aluminate, magnesium carbonate, calcium carbonate, urea formaline resin, heulandite, mordenite, desmine, chabazite etc· were used. With this method the author tryed severd determinations on rocks, minerals, mineral springs, organisms etc. The contento; of Cu, Zn, Ni and Co in rocks were 0.007, 0.008, 0.002 and 0.004% respectively. Cobalt content proved to be more than that of nickel. The mercury content of rocks was proved to be 10 times more to Clarke number, bismuth and cadmium content as same as or less than Clarke number. Silver in plants, soil and mineral waters, platinum in serpentine; mercury, cadmium, bismuth etc in mineral waters, trace heavy metals in organism, etc were determined. Radium B and Thorium B in hot spring waters were used as tracer. As organic solvents methyl-, ethyl-, butyl-, amy1-, octyl alcohol, dioxan, benzol, toluene, xylol, petroleum ether, ether, ethylacetate, chloloform, carbon tetrachloride, carbon disulfide etc were applied.
en-copyright=
kn-copyright=

en-aut-name=AshizawaTakashi
en-aut-sei=Ashizawa
en-aut-mei=Takashi
kn-aut-name=芦沢峻
kn-aut-sei=芦沢
kn-aut-mei=峻
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学溫泉研究所化学部
END

start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=
article-no=
start-page=1
end-page=9
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=196101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Studies on the coulometric determination of uranium (VI) and Thallium CD by Controlled Potential Electrolysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In recent years, coulometric analysis has been developed and widely used as a technique for the determination of substances in solution by measuring the quantity of electricity required for the completion of a reaction in an electrolysis cell. Of two coulometric techniques, i. e., coulometric titration with a constant current and coulometric analysis with a controlled potential of a working electrode, the latter is more interesting to the author, because by this method both electrolytic separation and quantitative determination of chemical species can be achieved simultaneously. Especially, the use of a mercury cathode as the working electrode(1)) has an advantage that the optimum control potentials can easily be determinable from
polarographic data. In our laboratory, we took up the coulometry of uranium as one of the interesting themes of researches when we had an opPortunity in studying various kinds of analytical methods for uranium in accordance with the request by Japan Atomic Fuel Corporation. The coulometric determination of uranium (VI) by using
a mercury cathode at a controlled potential was studied by G. L. Booman, W. B. Holbrook and ]. E. Rein(2)). It was found to be very useful for the analysis of uranium in a highly enriched nuclear element which underwent fission to an appreciable
extent. But the instrument used by them(3)) was complicated and expensive. Therefore, a simple counter millicoulometer has been coustructed in our laboratory, a readymade potentiostat (electrical instrument for automatic controlled potential electrolysis) being tried for electrolysis. By these instruments, the author studied the fundam ental conditions of coulometry for uranium and tried the successive determinations of uranium and thallium in mixed solutions.
en-copyright=
kn-copyright=

en-aut-name=SakanoueMasanobu
en-aut-sei=Sakanoue
en-aut-mei=Masanobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Division of Chemistry, Balneological Institute, Okayama University Misasa Hot Springs
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=2
article-no=
start-page=95
end-page=99
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=TGF-β-Smad3 pathway activates Sox9-dependent chondrogenesis
kn-title=TGF-β-Smad3経路と転写因子Sox9による軟骨細胞分化調節
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=古松毅之
kn-aut-sei=古松
kn-aut-mei=毅之
aut-affil-num=1
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=尾﨑敏文
kn-aut-sei=尾﨑
kn-aut-mei=敏文
aut-affil-num=2
ORCID=

en-aut-name=AsaharaHiroshi
en-aut-sei=Asahara
en-aut-mei=Hiroshi
kn-aut-name=浅原弘嗣
kn-aut-sei=浅原
kn-aut-mei=弘嗣
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=3
en-affil=
kn-affil=スクリプス研究所　分子実験医学
en-keyword=chondrogenesis
kn-keyword=chondrogenesis
en-keyword=epigenetic regulation
kn-keyword=epigenetic regulation
en-keyword=Smad3
kn-keyword=Smad3
en-keyword=Sox9
kn-keyword=Sox9
en-keyword=TGF-β
kn-keyword=TGF-β
END

start-ver=1.4
cd-journal=joma
no-vol=54
cd-vols=
no-issue=3-4
article-no=
start-page=233
end-page=239
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20064
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Elucidation of the role of the complex in hydride transfer reaction between methylene blue and 1-benzyl-1,4-dihydronictinamide by effect of &#947;-cyclodextrin
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>The kinetics of the hydride transfer reaction between Methylene Blue (MB<sup>+</sup>) and&#12288;1-benzyl-1,4-dihydronicotinamide (BNAH) were studied in 10 % ethanol-90 % water mixed solvents containing &#946;- and &#947;-cyclodextrins (&#946;-CD and &#947;-CD). The pseudo-first order rate constant shows kinetic saturation at high initial concentration of BNAH. This indicates the formation of a complex between MB<sup>+</sup> and BNAH. The reaction was suppressed by addition of &#946;-CD, but enhanced by addition of &#947;-CD. MB<sup>+</sup> and BNAH were separately accommodated within the &#946;-CD cavity and the cavity walls may protect the activity site of the reactants. On the other hand, in the MB<sup>+</sup>-BNAH-&#947;-CD system, the inclusion of the complex between MB+ and BNAH with &#947;-CD occurred. This effect of &#947;-CD can distinguish between the productive and non-productive nature of the complex.</p>

en-copyright=
kn-copyright=

en-aut-name=LiuYingin
en-aut-sei=Liu
en-aut-mei=Yingin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HotouchiNaoto
en-aut-sei=Hotouchi
en-aut-mei=Naoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SueishiYoshimi
en-aut-sei=Sueishi
en-aut-mei=Yoshimi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamamotoShunzo
en-aut-sei=Yamamoto
en-aut-mei=Shunzo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Okayama University
en-keyword=hydride transfer reaction
kn-keyword=hydride transfer reaction
en-keyword=reaction mechanism
kn-keyword=reaction mechanism
en-keyword=cyclodextrin
kn-keyword=cyclodextrin
en-keyword=inclusion complexes
kn-keyword=inclusion complexes
en-keyword=1-benzyl-1
kn-keyword=1-benzyl-1
en-keyword=4-dihydronicotinamide
kn-keyword=4-dihydronicotinamide
en-keyword=Methylene Blue
kn-keyword=Methylene Blue
END

start-ver=1.4
cd-journal=joma
no-vol=588
cd-vols=
no-issue=1
article-no=
start-page=73
end-page=81
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Synthesis of novel chitosan resin derivatized with serine diacetic acid moiety and its application to on-line collection/concentration of trace elements and their determination using inductively coupled plasma-atomic emission spectrometry
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A novel chelating resin functionalized with serine diacetic acid moiety was synthesized by using chitosan as base material, and applied to the collection/concentration of trace elements in environmental water samples, followed by the determination using inductively coupled plasma-atomic emission spectrometer (ICP-AES). The synthesized resin, crosslinked chitosan serine diacetic acid (CCTS-SDA), showed good adsorption behavior toward trace amounts of Cd, Pb, Cu, Ni, V, Ga, Sc, In, and Th in a wide pH range. Additionally, rare earth elements also can be retained on the resin at neutral pH region. The adsorbed elements can be easily eluted with 1 mol L-1 of nitric acid, and their recoveries were found to be 90-100%. The CCTS-SDA was packed in a mini-column, which was then installed in a cornputer-controlled auto-pretreatment system (Auto-Pret System) for on-line trace elements collection and determination with ICP-AES. Experimental parameters which related to the improvement of sensitivity and reproducibility were optimized. The limits of detection (LOD) for 13 elements were found to be in sub-ppb level. The proposed method with CCTS-SDA resin was successfully applied to the determination of trace elements in river water samples. The method was validated by determining a certified reference material of river water, SLRS-4.
en-copyright=
kn-copyright=

en-aut-name=LukmanHakim
en-aut-sei=Lukman
en-aut-mei=Hakim
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SabarudinAkhmad
en-aut-sei=Sabarudin
en-aut-mei=Akhmad
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=3
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=2
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=3
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=4
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University
en-keyword=chelating resin
kn-keyword=chelating resin
en-keyword=chitosan
kn-keyword=chitosan
en-keyword=serine diacetic acid moiety
kn-keyword=serine diacetic acid moiety
en-keyword=trace elements
kn-keyword=trace elements
en-keyword=on-line pretreatment
kn-keyword=on-line pretreatment
en-keyword=computer control
kn-keyword=computer control
en-keyword=inductively coupled plasma-atomic emission spectrometry
kn-keyword=inductively coupled plasma-atomic emission spectrometry
en-keyword=SLRS-4
kn-keyword=SLRS-4
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=5
article-no=
start-page=1609
end-page=1617
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070118
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sequential-injection on-line preconcentration using chitosan resin functionalized with 2-amino-5-hydroxy benzoic acid for the determination of trace elements in environmental water samples by inductively coupled plasma-atomic emission spectrometry
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>A new chelating resin using chitosan as a base material was synthesized. Functional moiety of 2-amino-5-hydroxy benzoic acid (AHBA) was chemically bonded to the amino group of cross-linked chitosan (CCTS) through the arm of chloromethyloxirane (CCTS-AHBA resin). Several elements, such as Ag, Be, Cd, Co, Cu, Ni, Ph, U, V, and rare earth elements (REEs), could be adsorbed on the resin. To use the resin for on-line pretreatment, the resin was packed in a mini-column and installed into a sequential-injection/automated pretreatment system (Auto-Pret System) coupled with inductively coupled plasma-atomic emission spectrometry (ICP-AES). The sequential-injection/automated pretreatment system was a laboratory-assembled, and the program was written using Visual Basic software. This system can provide easy operation procedures, less reagent consumption, as well as less waste production.

Experimental variables considered as effective factors in the improvement sensitivity, such as an eluent concentration, a sample and an eluent flow rate, pH of samples, and air-sandwiched eluent were carefully optimized. The proposed system provides excellent on-line collection efficiency, as well as high concentration factors of analytes in water samples, which results in highly sensitive detection of ultra-trace and trace analysis. Under the optimal conditions, the detection limits of 24 elements examined are in the range from ppt to sub-ppb levels. The proposed method was validated by using the standard reference material of a river water, SLRS-4, and the applicability was further demonstrated to the on-line collection/concentration of trace elements, such as Ag, Be, Cd, Co, Cu, Ni, Ph, U, V, and REEs in water samples.</p>
en-copyright=
kn-copyright=

en-aut-name=SabarudinAkhmad
en-aut-sei=Sabarudin
en-aut-mei=Akhmad
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=LenghorNarong
en-aut-sei=Lenghor
en-aut-mei=Narong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=3
ORCID=

en-aut-name=HakimLukman
en-aut-sei=Hakim
en-aut-mei=Lukman
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=GaoYun-Hua
en-aut-sei=Gao
en-aut-mei=Yun-Hua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=2
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=3
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=4
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=5
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=6
en-affil=
kn-affil=Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS)

affil-num=7
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University
en-keyword=sequential-injection
kn-keyword=sequential-injection
en-keyword=on-line preconcentration
kn-keyword=on-line preconcentration
en-keyword=trace elements
kn-keyword=trace elements
en-keyword=ICP-AES
kn-keyword=ICP-AES
en-keyword=chitosan resin
kn-keyword=chitosan resin
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=5
article-no=
start-page=589
end-page=594
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080510
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Determination of trace heavy metals by sequential injection-anodic stripping voltammetry using bismuth film screen-printed carbon electrode
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>A sequential injection-square-wave anodic stripping voltammetry (SIA-SWASV) is proposed for the simultaneous determination of Pb(II), Cd(II) and Zn(II), employing an in situ plated bismuth film screen-printed carbon electrode (Bi-SPCE) as a working electrode and hydrochloric acid as a supporting electrolyte. Bi(III) and analyte metal ions were on-line deposited onto a SPCE at -1.4 V vs. Ag/AgCl for 180 s. At a stopped flow, a square-wave voltammogram was recorded from -1.3 to 0 V vs. Ag/AgCl. The experimental conditions were optimized. Under the optimum conditions, the linear ranges were 0 - 70 mu g L-1 for Pb(II) and Cd(II), and 75 - 200 mu g L-1 for Zn(II). The limits of detection (S/N = 3) were obtained at concentrations as low as 0.89 mu g L-1 for Pb(II) and 0.69 mu g L-1 for Cd(II) for a 180-s deposition time. The proposed method was applied to the determination of Pb(II), Cd(II) and Zn(II) in water samples with satisfactory results.</p>

en-copyright=
kn-copyright=

en-aut-name=ChuanuwatanakulSuchada
en-aut-sei=Chuanuwatanakul
en-aut-mei=Suchada
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DungchaiWijitar
en-aut-sei=Dungchai
en-aut-mei=Wijitar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ChailapakulOrawon
en-aut-sei=Chailapakul
en-aut-mei=Orawon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Chulalongkorn University

affil-num=2
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Chulalongkorn University

affil-num=3
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Chulalongkorn University

affil-num=4
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University
en-keyword=DIAMOND THIN-FILM
kn-keyword=DIAMOND THIN-FILM
en-keyword=FLOW-INJECTION
kn-keyword=FLOW-INJECTION
en-keyword=PLATED CARBON; WATER SAMPLES; COPPER
kn-keyword=PLATED CARBON; WATER SAMPLES; COPPER
en-keyword=LEAD
kn-keyword=LEAD
en-keyword=ZINC
kn-keyword=ZINC
en-keyword=EXTRACTS
kn-keyword=EXTRACTS
en-keyword=CADMIUM
kn-keyword=CADMIUM
en-keyword=  CD(II)
kn-keyword=  CD(II)
END

start-ver=1.4
cd-journal=joma
no-vol=45
cd-vols=
no-issue=6
article-no=
start-page=445
end-page=449
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A human T cell leukemia virus type-I carrier with recurrent thrombocytopenia and various autoantibodies.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>A 34-year-old woman infected with human T cell leukemia virus type-I(HTLV-I) with recurrent thrombocytopenia and various autoantibodies is described. The platelet counts fluctuated between 1.3 x 10(4)/microliters and 14.8 x 10(4)/microliters without any medical treatment, and thrombocytopenia improved with a decrease of platelet-associated IgG (PA-IgG). Autoantibodies such as rheumatoid factor, antinuclear factor, anti-Sm, anti-RNP and anti-SSA antibodies were also recognized. Marker analysis of peripheral mononuclear cells showed an increase in the proportion of CD 25+ cells, CD 3+ HLA-DR+ cells, CD4+ HLA-DR+ cells and CD8+ HLA-DR+ cells. The recurrent thrombocytopenia and development of various autoantibodies in this HTLV-I carrier are speculated to be due to the alteration of B cell functions by T cells infected with HTLV-I.</p>

en-copyright=
kn-copyright=

en-aut-name=TakahashiIsao
en-aut-sei=Takahashi
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SanoMasayuki
en-aut-sei=Sano
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkamotoHideyuki
en-aut-sei=Okamoto
en-aut-mei=Hideyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShiromotoMasayoshi
en-aut-sei=Shiromoto
en-aut-mei=Masayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraToru
en-aut-sei=Nakamura
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=UenoKatsumi
en-aut-sei=Ueno
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakadaHiroshi
en-aut-sei=Nakada
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HarutaYuro
en-aut-sei=Haruta
en-aut-mei=Yuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SetoTakumi
en-aut-sei=Seto
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamashitaJiro
en-aut-sei=Yamashita
en-aut-mei=Jiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=YorimitsuSeiichi
en-aut-sei=Yorimitsu
en-aut-mei=Seiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MiyakeSusumu
en-aut-sei=Miyake
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MachidaKenichi
en-aut-sei=Machida
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KondaKeiji
en-aut-sei=Konda
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=TamuraTetuo
en-aut-sei=Tamura
en-aut-mei=Tetuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=ImajouKenji
en-aut-sei=Imajou
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=KimuraIkuro
en-aut-sei=Kimura
en-aut-mei=Ikuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Kochi Municipal Central Hospital

affil-num=3
en-affil=
kn-affil=Kochi Municipal Central Hospital

affil-num=4
en-affil=
kn-affil=Okayama University

affil-num=5
en-affil=
kn-affil=Okayama University

affil-num=6
en-affil=
kn-affil=Okayama University

affil-num=7
en-affil=
kn-affil=Okayama University

affil-num=8
en-affil=
kn-affil=Kochi Municipal Central Hospital

affil-num=9
en-affil=
kn-affil=Kochi Municipal Central Hospital

affil-num=10
en-affil=
kn-affil=Okayama University

affil-num=11
en-affil=
kn-affil=Kochi Municipal Central Hospital

affil-num=12
en-affil=
kn-affil=Kochi Municipal Central Hospital

affil-num=13
en-affil=
kn-affil=Kochi Municipal Central Hospital

affil-num=14
en-affil=
kn-affil=Kochi Municipal Central Hospital

affil-num=15
en-affil=
kn-affil=Kochi Municipal Sukumo Hospital

affil-num=16
en-affil=
kn-affil=Okayama University

affil-num=17
en-affil=
kn-affil=Okayama University
en-keyword=recurrent thrombocytopenia
kn-keyword=recurrent thrombocytopenia
en-keyword=HTLV-I
kn-keyword=HTLV-I
en-keyword=HTLV-I carier
kn-keyword=HTLV-I carier
END

start-ver=1.4
cd-journal=joma
no-vol=45
cd-vols=
no-issue=4
article-no=
start-page=257
end-page=265
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Changes of lymphocyte subsets in leukemia patients who received allogenic bone marrow transplantation.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Proportional changes of lymphocyte subsets in the peripheral blood were monitored by two-color flow-cytometry in seven leukemia patients who had received allogenic bone marrow transplantation (BMT). Lymphocyte counts, and proportions of T and B-cells returned to normal ranges between the 2nd and 12th months after BMT. Activated T-cells prominently increased after BMT, and the values gradually returned toward normal. As to lymphocyte subsets, the proportions of CD 4+ cells had remained low, while those of CD 8+ cells high for a whole observation period after BMT. The changes of CD 4+ cells were caused by the decrease of suppressor-inducer T-cells (CD 4+ Leu 8+). High proportion of CD 8+ cells was mainly associated with increased suppressor T-cells (CD 8+ CD 11+). Among natural killer (NK) cells, highly active NK cells (CD 16+ CD 57-) markedly increased shortly after BMT, and gradually returned to normal. CD 16 -CD 57+ NK cells increased beyond normal ranges after the 2nd month. The incidence or degree of acute and chronic graft-versus-host diseases (GVHD) did not correlate with the changes of any lymphocyte subsets. The present results suggest that the increase of activated T-cells shortly after BMT reflects lymphocyte reconstitution. The prolonged immune deficiency after BMT might be related to either deficient expression of homing receptor (Leu 8 antigen) on CD 4+ cells or increased suppressor T-cells (CD 8+ CD 11+). In addition, the early increase of NK cells after BMT may compensate for the immune deficiency in BMT patients.</p>

en-copyright=
kn-copyright=

en-aut-name=KomatsudaMitsumoto
en-aut-sei=Komatsuda
en-aut-mei=Mitsumoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama  University
en-keyword=immunologic reconstitution
kn-keyword=immunologic reconstitution
en-keyword=lymphocyte subsets
kn-keyword=lymphocyte subsets
en-keyword=graft-versus-host diseases
kn-keyword=graft-versus-host diseases
en-keyword=allogenic bone marrow transplantation
kn-keyword=allogenic bone marrow transplantation
END

start-ver=1.4
cd-journal=joma
no-vol=63
cd-vols=
no-issue=2
article-no=
start-page=71
end-page=78
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Expression of thyroglobulin on follicular dendritic cells of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma. We examined whether B cell response to thyroglobulin (Tg), which is a common thyroid-specific autoantigen, is related etiologically to the pathogenesis of thyroid MALT lymphoma. Expression of human Tg antigens and Cluster of differentiation (CD) 35 was examined immunohistochemically in 15 cases of thyroid MALT lymphoma using paraffin-embedded, formalin-fixed tissue specimens. In all cases of thyroid MALT lymphoma, human Tg was detected immunohistochemically in the follicular epithelial cells and follicular dendritic cells (FDCs). These FDCs were positive by double immunostaining for anti-human Tg rabbit polyclonal antibody (Ab) and for CD35. Results showed that the Tg, a thyroid autoantigen, had immunostained the germinal center of the thyroid MALT lymphoma. The Tg was present in the FDCs, as revealed by the staining pattern of the germinal center;this fact was confirmed by double immunostaining of anti-human Tg mouse monoclonal Ab and anti-CD35 mouse monoclonal Ab. The results of our study suggest that Tg is an autoantigen that is recognized by thyroid MALT lymphoma cells.</p>
en-copyright=
kn-copyright=

en-aut-name=MunemasaMitsuru
en-aut-sei=Munemasa
en-aut-mei=Mitsuru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YoshinoTadashi
en-aut-sei=Yoshino
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KobayashiKeita
en-aut-sei=Kobayashi
en-aut-mei=Keita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyakeTakayoshi
en-aut-sei=Miyake
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakugawaSumie Takase
en-aut-sei=Sakugawa
en-aut-mei=Sumie Takase
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MannamiTomohiko
en-aut-sei=Mannami
en-aut-mei=Tomohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShinagawaKatsuji
en-aut-sei=Shinagawa
en-aut-mei=Katsuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AkagiTadaatsu
en-aut-sei=Akagi
en-aut-mei=Tadaatsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=8
en-affil=
kn-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=9
en-affil=
kn-affil=Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=thyroglobulin
kn-keyword=thyroglobulin
en-keyword=follicular dendritic cells
kn-keyword=follicular dendritic cells
en-keyword=mucosa-associated lymphoid tissue lymphoma
kn-keyword=mucosa-associated lymphoid tissue lymphoma
END

start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=35
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=197102
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Conformational studies of mitochondrial DNA
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Ring DNA from rat liver mitochondria has been examined by circular dichroism (CD) in the region of the 225 to 320 m/~ and the followings have been clarified. The ring DNA gives a CD spectral curve somewhat different from linear DNA from nuclei, showing a big positive peak at 266 m/~ and a small negative band at 243 m!~. That is, the positive CD band of ring DNA shifted by about 7 m/~ to the shorter wavelength side from the band of the ordinary nuclear DNA, 273 m!~. Negative band appeared at the same region as that of linear DNA but reduced in depth. Heat denaturation of the ring DNA induced a red shift of the positive band, by about 4 mp., but no change in negative band. From these experimental results it has been concluded that the ring DNA has highly twisted
conformation and high in G.C contents, both of which are responsible for the blue shift of the CD spectrum.</p>

en-copyright=
kn-copyright=

en-aut-name=ItoNobutaka
en-aut-sei=Ito
en-aut-mei=Nobutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyaharaMasanobu
en-aut-sei=Miyahara
en-aut-mei=Masanobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SenoSatimaru
en-aut-sei=Seno
en-aut-mei=Satimaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=2
article-no=
start-page=69
end-page=75
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1988
dt-pub=198804
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Antitumor effect of combined intraperitoneal administration of human recombinant interferon-beta and interferon-gamma against intraabdominal carcinomatosis in nude mice.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>The development of useful therapy for intraabdominal carcinomatosis originating from gastrointestinal cancer is an important theme in cancer therapy. We developed recently an experimental model of intraabdominal carcinomatosis in nude mice by intraperitoneal transplantation of human colon cancer cells (RPMI 4788). Using this model, we investigated the antitumor effects of recombinant human interferon (rIFN)-beta and rIFN-gamma administered singly or in combination. Treatment was initiated 2 days after CD-1 nude mice were inoculated intraperitoneally with 5 X 10(6) RPMI 4788 cells. Intraperitoneal administration for 10 consecutive days of either rIFN-beta (2.5 X 10(5) IU/mouse/day) or rIFN-gamma (2.5 X 10(5) JRU/mouse/day) resulted in a significant prolongation of survival compared with the saline control group [survival in the control: 41.8 +/- 5.6 days (mean +/- SD)]. Combined administration of rIFN-beta and rIFN-gamma for 10 days yielded a marked synergistic effect on the prolongation of survival (114.0 +/- 8.2 days). However, combined administration of rIFN-beta and rIFN-gamma in a single dose equal to the total dose given fractionally over 10 days did not yield a synergistic effect. These results suggest that daily administration of rIFN-beta and rIFN-gamma combined may provide a highly potent antitumor effect against human peritoneal carcinomatosis.</p>
en-copyright=
kn-copyright=

en-aut-name=KondoHidenori
en-aut-sei=Kondo
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama  University

affil-num=2
en-affil=
kn-affil=Okayama  University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Okayama  University
en-keyword=antitumor effect
kn-keyword=antitumor effect
en-keyword=human recombinant interferon
kn-keyword=human recombinant interferon
en-keyword=synergistic effect
kn-keyword=synergistic effect
en-keyword=intrabdominal carcinomatosis
kn-keyword=intrabdominal carcinomatosis
en-keyword=mude mice
kn-keyword=mude mice
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930413
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Measurement of Magnetic characteristics in arbitrary directions of grain-oriented silicon steel
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakataTakayoshi
en-aut-sei=Nakata
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakahashiNorio
en-aut-sei=Takahashi
en-aut-mei=Norio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiwaraKoji
en-aut-sei=Fujiwara
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakanoMasanori
en-aut-sei=Nakano
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=
article-no=
start-page=4
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=199908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Determination of trace metals in environmental water samples by inductively coupled plasma - mass spectrometry (ICP-MS)
kn-title=誘導結合プラズマ―質量分析法による環境水中の微量金属の定量
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Trace metals in water samples, such as tap water, river water, and sea water, were determined by inductively coupled plasma-mass spectrometry (ICP-MS). ICP-MS has sufficient sensitivity to detect even below the concentrations of ppt level, and therefore the samples were not pretreated with a concentration column. Practical samples were diluted by lo-fold with ultrapure water and measured directly by ICP-MS. The measuring time of one sample was 2.5 min, and the data for 30 elements were obtained simultaneously. The concentrations of heavy metals, such as Cr, Mn, Co, Ni, Cu, Zn, As, Cd, Sb, and Pb, in the water samples were in the ranges of 0.05~82ng/ml. Zasu river and Sibukawa (sea water) contained various kinds of metals, and the concentration ranges were spread in a wide range; for example, Mg was 25700 ppb and In was 2 ppt. ICP-MS is found to be a useful and a powerful instrument for trace amounts of elements, and can be applied satisfactorily to the environmental water analysis.
en-copyright=
kn-copyright=

en-aut-name=LeeKyue-Hyung
en-aut-sei=Lee
en-aut-mei=Kyue-Hyung
kn-aut-name=李啓熒
kn-aut-sei=李
kn-aut-mei=啓熒
aut-affil-num=1
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=2
ORCID=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=高柳俊夫
kn-aut-sei=高柳
kn-aut-mei=俊夫
aut-affil-num=3
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学理学部化学科

affil-num=2
en-affil=
kn-affil=岡山大学理学部化学科

affil-num=3
en-affil=
kn-affil=岡山大学理学部化学科

affil-num=4
en-affil=
kn-affil=岡山大学理学部化学科
END

start-ver=1.4
cd-journal=joma
no-vol=36
cd-vols=
no-issue=3
article-no=
start-page=207
end-page=209
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=19870305
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Spectrophotometric determination of nitrate ion using nitrosation/FIA
kn-title=ニトロソ化反応を利用する硝酸イオンのフローインジェクション/吸光光度法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=N, N-Bis (2-hydroxypropyl) aniline (BHPA) reacts with nitrite ion in an acidic medium to form a red product, which has the maximum absorption at 500 nm. On the basis of this color reaction, FIA of nitrate was established. Nitrate ion could be reduced to nitrite ion by passing through the reduction column(2 mm×30 cm) packed with copperized cadmium {Cu(Cd) : particle size, about 0.5 mm}, which was installed just behind the sample injection valve. The carrier solution(10(-3) M EDTA, pH 8) and the reagent solution (8×10(-4) M BHPA, 0.35 M HCl, 0.15 M H(3)PO(4)) were propelled at the flow rate of 0.7 ml/min by using a double-plunger pump. The sample(120 μl) was injected into the carrier stream by using a 6-way injection valve. The reaction coil(0.5 mm×2 m) was kept in a thermostatically controlled water bath(80℃). The cooling coil(0.5 mm×50 cm), which was installed just behind the reaction coil, was kept in a water bath (tap water temperature). A calibration curve was linear up to 2×10(-4) M nitrate. The detection limit corresponding to S/N=2 was 10(-6) M nitrate, and the relative standard deviation (10 injections) was 0.4%, and the sampling rate was 40 samples per hour. Nitrate in river water at concentrations of 10(-5) M level was determined.
en-copyright=
kn-copyright=

en-aut-name=ShiCheng Rui
en-aut-sei=Shi
en-aut-mei=Cheng Rui
kn-aut-name=石成瑞
kn-aut-sei=石
kn-aut-mei=成瑞
aut-affil-num=1
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=2
ORCID=

en-aut-name=ToeiKyoji
en-aut-sei=Toei
en-aut-mei=Kyoji
kn-aut-name=桐栄恭二
kn-aut-sei=桐栄
kn-aut-mei=恭二
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学
en-keyword=FIA of nitrate
kn-keyword=FIA of nitrate
en-keyword=reduction of nitrate to nitrite on Cu (Cd) column
kn-keyword=reduction of nitrate to nitrite on Cu (Cd) column
en-keyword=color reaction of nitrite with N
kn-keyword=color reaction of nitrite with N
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=7
article-no=
start-page=731
end-page=738
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20000710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Simultaneous Determination of Trace Elements in River-water Samples by ICP-MS in Combination with a Discrete Microsampling Technique after Enrichment with a Chitosan-based Chelating Resin
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A new technique for the preconcentration of trace elements and matrix elimination with a chitosan-based chelating resin was proposed as a useful pretreatment prior to a measurement by inductively coupled plasma-mass spectrometry (ICP-MS). A small volume of the sample solution (80 µl) was discretely introduced into a nebulizer of ICP-MS using a segmented flow injection (SFI) system; a maximum of fifteen elements were simultaneously measured by a single injection. A chitosan-based chelating resin containing iminodiacetate (IDA) functional groups was used for matrix elimination and enrichment of analyte metal ions. Several metal ions, such as Al, Fe, Ni, Co, Cu, Zn, Ag, Cd, Pb and U, were quantitatively retained on the IDA chelating resin in a micro-column (resin: 1 ml) at pH 6, whereas Na, K, Mg and Ca were completely eluted from the column by washing with an ammonium acetate solution. The concentrations of 24 and 26 elements in river water certified reference materials, JAC 0031 and JAC 0032, respectively, were determined by the proposed SFI/ICP-MS system after pretreating the samples with the proposed technique, as well as without any pretreatment. The thus-obtained analytical data were evaluated by comparing them with the reference values, as well as with those obtained in other studies.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=LeeKyue-Hyung
kn-aut-sei=Lee
kn-aut-mei=Kyue-Hyung
aut-affil-num=1
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=2
ORCID=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=高柳俊夫
kn-aut-sei=高柳
kn-aut-mei=俊夫
aut-affil-num=3
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=12
article-no=
start-page=873
end-page=880
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19931205
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Separation of metal ions and the determination of calcium and magnesium ions with N, N'-di(2-hydroxybenzyl)ethylenediamine-N, N'-diacetic acid by high-performance capillary electrophoresis
kn-title=キャピラリー電気泳動によるN,N'-ジ(2-ヒドロキシベンジル)エチレンジアミン-N,N'-二酢酸を用いる金属イオンの分離とカルシウム及びマグネシウムイオンの定量
en-subtitle=
kn-subtitle=
en-abstract=The capillary electrophoresis study was carried out by using HBED as a chelating and coloring agent. The title compound HBED(H(4)Y) reacts with divalent (M(2+)) and trivalent metal ions (M(3+)) to form chelate anions MY(2-) and MY(-), respectively. Eleven divalent metal ions and three trivalent metal ions were detected as peaks at pH 9.3. When a carrier containing 2 × 10(-3) M HBED (pH 10.5) and sample solutions containing 1 × 10(-4) M HBED were used, the mobilities of the metal ions (absolute value) increased in the following order: Co(2+) (Co(3+)) (2.05) < Mn(2+) (2.10) < Al(3+) (2.12) < Fe(3+) (2.15) < Pb(2+) (2.64)<Hg(2+) (3.20)<Cd(2+) (3.21)<Ca(2+) (3.26)<Ni(2+) (3.34)<Cu(2+)(3.42)<Zn(2+) (3.52) < Pd(2+) (3.60)< HBED(3.74). Most of the metal ions form stable chelates at about pH 10. HBED chelates absorb UV light strongly at longer wavelenghs near to 294 nm, compared with EDTA chelates; highly sensitive detection of metal ions could be achieved with HBED. The proposed method with HBED was applied to the determination of calcium and magnesium ions in river water and serum samples.
kn-abstract=表題のEDTA類縁試薬(HBEDと略記)を用いて金属イオンのキャピラリー電気泳動について検討した.HBED(H(4)Y)は二価及び三価金属イオン(Mn+)と反応し,MY(2-),MY(-)型キレート陰イオンを形成する.pH9～10で11種の二価金属イオンと2種の三価金属イオンのピークを得た.2×10(-3)M HBEDを含むpH10.5の泳動液を用いた場合,金属イオンの移動度(絶対値)は次の順に大きくなる(見掛けのイオン移動度):Co(2+)(2.05)<Mn(2+)(2.10)<Al(3+)(2.12)<Fe(3+)(2.15)<Pb(2+)(2.64)<Hg(2+)(3.20)<Cd(2+)(3.21)<Ca(2+)(3.26)<Ni(2+)(3.34)<Cu(2+)(3.42)<Zn(2+)(3.52)<Pd(2+)(3.60)<HBED(3.74).イオン移動度に及ぼすpHの影響から,大部分の金属イオンはpH10付近で安定なキレートを生成することが分かった.HBEDキレートは,EDTAに比べ,長波長(294nm付近)に強い吸収を示し高感度定量が可能である.本法を河川水,血清中のCa(2+),Mg(2+)の定量に応用し,良好な結果を得た.
en-copyright=
kn-copyright=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=1
ORCID=

en-aut-name=MorimotoKouji
en-aut-sei=Morimoto
en-aut-mei=Kouji
kn-aut-name=森本浩司
kn-aut-sei=森本
kn-aut-mei=浩司
aut-affil-num=2
ORCID=

en-aut-name=KuwabaraMasayoshi
en-aut-sei=Kuwabara
en-aut-mei=Masayoshi
kn-aut-name=桑原正良
kn-aut-sei=桑原
kn-aut-mei=正良
aut-affil-num=3
ORCID=

en-aut-name=ObataYoshimitsu
en-aut-sei=Obata
en-aut-mei=Yoshimitsu
kn-aut-name=小畑義光
kn-aut-sei=小畑
kn-aut-mei=義光
aut-affil-num=4
ORCID=

en-aut-name=IzumiKunitatsu
en-aut-sei=Izumi
en-aut-mei=Kunitatsu
kn-aut-name=泉国辰
kn-aut-sei=泉
kn-aut-mei=国辰
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=アプライドバイオシステムズ

affil-num=5
en-affil=
kn-affil=アプライドバイオシステムズ
en-keyword=high-performance capillary electrophoresis
kn-keyword=high-performance capillary electrophoresis
en-keyword=separation of metal ions
kn-keyword=separation of metal ions
en-keyword=determination of calcium and magnesium
kn-keyword=determination of calcium and magnesium
en-keyword=N, N'-di(2-hydroxybenzyl)ethylenediamine-N
kn-keyword=N, N'-di(2-hydroxybenzyl)ethylenediamine-N
END

start-ver=1.4
cd-journal=joma
no-vol=47
cd-vols=
no-issue=6
article-no=
start-page=375
end-page=380
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980605
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Simultaneous determination of nitrate and nitrite ion by micro-flow injection analysis
kn-title=マイクロフローインジェクション分析法による硝酸,亜硝酸イオンの同時定量
en-subtitle=
kn-subtitle=
en-abstract=試薬,試料量の低減化とオンサイト分析を目的として,マイクロフロー方式FIA(μFIA)による硝酸イオン,亜硝酸イオンの定量について検討した.流路は二流路とし,ダブルプランジャー型マイクロポンプを用い,吐出量は2.5μl stroke-1,流量は50μl min-1とした.吸光検出反応には,スルファニルアミドと2-ナフチルエチレンジアミンを用いるジアゾ化-カップリング反応を用い,538nmで測定した.試料注入量20μlで,内径0.25mm,長さ75 cmの反応コイルを用いれば,通常の河川水程度の硝酸,亜硝酸イオンの定量が可能である.μFIA用のCd/Cu還元ミニカラムは,カドミウムパウダー(60～80メッシュ)を銅コーティングし,内径0.53mmのシリカチューブ(長さ5cm)に詰めて作製した.本ミニカラムによる硝酸イオンの亜硝酸イオンへの還元効率は99%以上であった.スプリット方式により,硝酸亜硝酸イオンの同時定量用流路を構築した.実際試料のオンサイト分析装置には,発光ダイオード(LED)を川いて,消費電力の低減化を計った.硝酸,亜硝酸イオンを単独に定量する場合の検出限界はそれぞれ約2×10(-8)Mであり,同時定量の場合には約10(-7)Mであった.河川水中の硝酸,亜硝酸イオンの同時定量にも応用できることが分かった.
kn-abstract=To minimize the sample size, reagent consumption and waste, a micro-flow injection analysis (μFIA) was investigated and applied to the simultaneous determination of nitrate and nitrite ion in water samples. A double-plunger micropump was used to propel a carrier and a chromogenic solution; each flow rate was 50 μl min(-1), and the delivery volume was 2.5 μl per stroke. Nitrate was reduced to nitrite on line by passing through a mini column (0.53 mm i.d.×5 cm) packed with powdered Cd/Cu (6080 mesh). The reduction efficiency was 99% using this reduction column. Detection was carried out at 538 nm with a light-emitting diode used as an azo dye. The carrier solution contained EDTA and NaCl (pH 8.18.4) and the reagent solution contained sulfanilamide, N-(1-naphthyl)ethylenediamine and HCl. For a simultaneous determination, the sample injected into the carrier stream was split into two streams: one passed through the mini Cd/Cu column ; the other passed through a bypass column packed with glass beads. The sample zone passing through the bypass column gave a first peak derived from nitrite; the other sample zone passing through the reduction column gave the second peak derived from nitrate and nitrite. The detection limits of nitrate and nitrite were about 1×10(-7) M using the proposed simultaneous determination system.
en-copyright=
kn-copyright=

en-aut-name=MaLan
en-aut-sei=Ma
en-aut-mei=Lan
kn-aut-name=馬蘭
kn-aut-sei=馬
kn-aut-mei=蘭
aut-affil-num=1
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=2
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=3
ORCID=

en-aut-name=HattoriTakayasu
en-aut-sei=Hattori
en-aut-mei=Takayasu
kn-aut-name=服部隆康
kn-aut-sei=服部
kn-aut-mei=隆康
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=旭テクネイオン(株)
en-keyword=micro-flow injection analysis
kn-keyword=micro-flow injection analysis
en-keyword=river water, nitrate and nitrite
kn-keyword=river water, nitrate and nitrite
en-keyword=simultaneous determination
kn-keyword=simultaneous determination
en-keyword=mini Cd/Cu reduction column
kn-keyword=mini Cd/Cu reduction column
END

start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=9
article-no=
start-page=785
end-page=789
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020905
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Highly sensitive determination of copper ion with newly synthesized water-soluble fluorescent reagents having a 1,8-diaminonaphthalene-3,6-disulfonic acid skeleton
kn-title=1,8-ジアミノナフタレン-3,6-ジスルホン酸骨格を持つ新規水溶性蛍光試薬の合成と銅イオンの高感度定量への応用
en-subtitle=
kn-subtitle=
en-abstract=水溶性蛍光試薬として1,8-ジヒドロキシナフタレン-3,6-ジスルホン酸 (クロモトロープ酸) に類似した1,8-ジアミノナフタレン-3,6-ジスルホン酸骨格を持つ1,8-ジ-(トルエン-4-スルホニルアミノ)-ナフタレン-3,6-ジスルホン酸 (BTND) 及び1,8-ジ-(トリフルオロメタンスルホニルアミノ)-ナフタレン-3,6-ジスルホン酸 (BTFND) を合成し, 金属イオンとの反応性を検討した. BTFNDは検討した8種類の金属イオンと反応し消蛍光を示した. またBTNDは銅 (II) イオンと選択的に反応することが分かった. BTNDは水溶液中pH7で銅 (II) イオンと定量的に反応し, 消蛍光を示したので, 検量線を作成したところ, 銅濃度0～10(-6)Mの範囲で直線関係を示した (λ(ex)=360nm, λ(em)=405nm). 本法の銅 (II) イオンの検出下限は2.0×10(-7)Mであった. BTNDは水溶液中で反応し, 定量操作が簡便で, 銅 (II) イオンに対する高感度・高選択的な蛍光試薬であることが分かった.
kn-abstract=Water-soluble fluorescent reagents, 1,8-di-(toluene-4-sulfonylamino)-naphthalene-3,6-disulfonic acid (BTND) and 1,8-di-(trifluoromethanesulfonylamino)-naphthalene-3,6-disulfonic acid (BTFND), were newly synthesized. The reactivities of these fluorescent reagents to Cu(2+), Ni(2+), Co(2+), Cd(2+), Pb(2+), V(V), Ag(+), Fe(3+), and Mg(2+) were examined. BTFND was reacted with 8 metal ions, except for Pb(2+), to show fluorescence quenching. BTND was selective to Cu(2+), and the fluorescence was quenched quantitatively at pH 7 in an aqueous solution (λ(ex)=360 nm and λ(em)=405 nm). The calibration graph for Cu(2+) with BTND was rectilinear over the concentration range from 0 to 10(-5) M and the detection limit was 2.0×10(-7) M. BTND has many advantages, such as selectivity for Cu(2+), high sensitivity, and a simple procedure.
en-copyright=
kn-copyright=

en-aut-name=NomuraKazuhiro
en-aut-sei=Nomura
en-aut-mei=Kazuhiro
kn-aut-name=野村一央
kn-aut-sei=野村
kn-aut-mei=一央
aut-affil-num=1
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=2
ORCID=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=高柳俊夫
kn-aut-sei=高柳
kn-aut-mei=俊夫
aut-affil-num=3
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
en-keyword=determination of copper ion
kn-keyword=determination of copper ion
en-keyword=1,8-di-(toluene-4-sulfonylamino)-naphthalene-3,6-disulfonic acid
kn-keyword=1,8-di-(toluene-4-sulfonylamino)-naphthalene-3,6-disulfonic acid
en-keyword=1,8-di-(trifluoromethane-4-sulfonylamino)-naphthalene-3,6-disulfonic acid
kn-keyword=1,8-di-(trifluoromethane-4-sulfonylamino)-naphthalene-3,6-disulfonic acid
en-keyword=fluorescence detection
kn-keyword=fluorescence detection
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=1
article-no=
start-page=147
end-page=158
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=19990226
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Photoconductive and Photovoltaic Properties in Cadmium Bismuth Aluminate Glasses
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Photo-induced phenomena such as photoconductive and photovoltaic effects were investigated for the glasses in CdO-Bi(2)O(3)-Al(2)O(3) system. Photoconductive effect was characterized by a slow decay of photocurrent (persitent photoconductivity). The decay rate decreased with increasing CdO content and decreasing Bi(2)O(3) content. Photovoltage was very small at room temperature but increased to an obvious value on heating. The photoconductivity and photovoltage were increased with CdO content and enhanced by heat treatment in air. The valence band spectra of X-ray photoelectron spectroscopy showed that the hybridization of Cd 4d and O 2p orbitals increases with decreasing Bi(2)O(3) content and increasing CdO content in the glasses. As the results maximum tends to flat. This type of band structure inhibits the rapid recombination of electrons and holes. The persistent photoconductivity of the glasses may be attributed to deep energy level of DX centers. Deep energy levels of the glasses are able to prevent the recombination because they have a repulsive barrier for both electron emission and capture.
en-copyright=
kn-copyright=

en-aut-name=ChenDanping
en-aut-sei=Chen
en-aut-mei=Danping
kn-aut-name=陳丹平
kn-aut-sei=陳
kn-aut-mei=丹平
aut-affil-num=1
ORCID=

en-aut-name=WatanabeTomohiro
en-aut-sei=Watanabe
en-aut-mei=Tomohiro
kn-aut-name=渡辺智大
kn-aut-sei=渡辺
kn-aut-mei=智大
aut-affil-num=2
ORCID=

en-aut-name=MiuraYoshinari
en-aut-sei=Miura
en-aut-mei=Yoshinari
kn-aut-name=三浦嘉也
kn-aut-sei=三浦
kn-aut-mei=嘉也
aut-affil-num=3
ORCID=

en-aut-name=NanbaTokuro
en-aut-sei=Nanba
en-aut-mei=Tokuro
kn-aut-name=難波徳郎
kn-aut-sei=難波
kn-aut-mei=徳郎
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Wuhan University of Technology

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
en-keyword=Photoconductivity
kn-keyword=Photoconductivity
en-keyword=Photovoltage
kn-keyword=Photovoltage
en-keyword=Persistent photoconductivity
kn-keyword=Persistent photoconductivity
en-keyword=CdO-Bi(2)O(3)-Al(2)O(3) glasses
kn-keyword=CdO-Bi(2)O(3)-Al(2)O(3) glasses
en-keyword=Electronic state
kn-keyword=Electronic state
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=12
article-no=
start-page=4379
end-page=4382
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Hemolytic Substance from the Animals Infected with Tubercle Bacillus Part 2. Chemical Studies on the Hemolytic Substance
kn-title=結核感染動物の生体内に発生する溶血性物質に関する研究 第2編 結核感染動物の臓器より抽出した溶血性物質の精製
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the first paper the author reported that in the course of tnberculous infection a fairly large quantity of hemolytic substances were produced in the organs, especially in lymph nodes and spleen. In this paper the author reports the studies on the chemical nature of them. Dissolving the browhish viscous stbstance from the aceton insoluble fraction in pure ethanol, the substance was precitated as the Cd-salt by adding cadomium chloride solution. Precipitant was dissolved in chloroform and removed Cd by centrifugation after adding ammonium alcohol. The supernatant was dried and dissolved in pure ethanol. By drying again under a low pressure white needle-like crystals have been obtained. This substance proved to hemolyze completely the rabbit erythrocytes suspended in the saline solution in the concentration of 55 × 10⁻⁵ % . Comparing these crystal forms, hemolytic activity and the solubility in the organic solvents with those of the pure lysolecithin obtained from the rice grain, it is proved that these hemolytic substances are nothing but lysolecthin. The substance from the aceton soluble fraction is fatty acids produced by the decomposition of lecithin.
en-copyright=
kn-copyright=

en-aut-name=KobayashiMinoru
en-aut-sei=Kobayashi
en-aut-mei=Minoru
kn-aut-name=小林実
kn-aut-sei=小林
kn-aut-mei=実
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部病理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=7
article-no=
start-page=2607
end-page=2618
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cyto-architectonic and histochemical studies of the caudata nucleus in cat's brain with special reference to convulsion Part Ⅱ Histochemical study of choline-esterase in areas of the caudate nucleus of cat's brain with convulsion
kn-title=猫脳尾状核の細胞構築学的研究ならびに痙攣時の組織化学的研究 第2編 実験的痙攣猫脳尾状核各分野のコリンエステラーぜ（ChE）に関する組織化学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ten per cent metrazol solution was experimentally injected in cats and the changes of choline-esterase (ChE) at the maximum stage of convulsion was histochemically investigated by Koelle modification. 1) The ChE of nerve cells mostly increased in normal cases relatively in peripheral part of protoplasma, while in convulsion cases it was considered to be even in central part of protoplasma. 2) ChE is increased in each area of the caudate nucleus by convulsion. 3) The increase is especially remarkable in the large cells of the caudate nucleus. 4) The dorsolateral side of the caudate nucleus (Cd., Cm.) has more increase of ChE than the ventromedial side by convulsion, and Cm. has the most increase, then in the order of Cd., Cl. and Cv. to the least. 5) In cases without convulsion, there is no difference of ChE distribution among these areas, and even the large cells have no marked increase of ChE.
en-copyright=
kn-copyright=

en-aut-name=NishiwakiKorenobu
en-aut-sei=Nishiwaki
en-aut-mei=Korenobu
kn-aut-name=西脇惟信
kn-aut-sei=西脇
kn-aut-mei=惟信
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=7
article-no=
start-page=2599
end-page=2606
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=1958
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cyto-architectonic and histochemical studies of the caudate nucleus in cat's brain with special reference to convulsion Part Ⅰ. On the size and density of the nerve cells in areas of the caudate nucleus of cat's brain
kn-title=猫脳尾状核の細胞構築学的研究ならびに痙攣時の組織化学的研究 第1編 猫脳尾状核各分野の神経細胞の大さと密度とに関する研究
en-subtitle=
kn-subtitle=
en-abstract=According to the Gurewitsch classification, the caudate nucleus was devided into the areas of Cd., Cm., Cl. and Cv. and the size (long diameter) and density were measured. 1) Each area has two kinds of nerve cells with different size and the cell larger than 24 μ is called the large cell (so-called the effective cell of Gurewitsch), and smaller called the small cell (so-called the receptive cell of Gurewitsch). 2) The density of the large cells is 1.8% at Cd., 1.5% at Cm., 0.8% at Cl. and 0.2% at Cv., thus the dorsolateral side of the caudate nucleus (Cd. and Cm.) has more large cells with even larger size than the ventromedial side (Cl. and Cv.). 3) The density of the nerve cells is increasing from the dorsolateral side to the ventromedial and has the following rate: Cd. 9, Cm. 10, Cl. 11 and Cv. 13.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NishiwakiKorenobu
en-aut-sei=Nishiwaki
en-aut-mei=Korenobu
kn-aut-name=西脇惟信
kn-aut-sei=西脇
kn-aut-mei=惟信
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=8-9
article-no=
start-page=741
end-page=755
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Histoplasma Capsulatum Part 1. Fungus Virulence and Histopathology in CF-1 Mice Inoculated with Histoplasma Capsulatum Okayama-56 (Yamato)
kn-title=Histoplasma capsulatumに関する研究 第1編 各種接種方法によるHistoplasma eapsulatum Okayama-56 (Yamato) のCF-1系マウスに対する毒力並びに病理組織学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mycological and histopathological characteristics of the yeast phase of an isolated fungus, Histoplasma capsulatum Okayama-56 (Yamato), cultured at 37°C were investigated and the results obtained were as follows: 1. The lethality within 4 weeks in the mice of seven inbred lines given 1.0 mg of the culture intravenously was to be compared as, CF-1=dba-2>> AKR>BALB/c>A>ddT=C57 Br/cd. 2. The minimum lethal dose of CF-1 mice was 1.2 mg by means of intravenous injection. 3. The lethality within 4 weeks of CF-1 mice administered 1.0 mg of the culture intracranially, intravenously, intraperitoneally and by inhalation was 90, 80, 40 and 30 per cent respectively. 4. The most extensive and general pathologic changes were observed in the mice received intravenous injections, and in other cases the lesions produced were more or less localized at the site of invasion. The nature of changes was mostly to be interpreted as productive and granulomatous inflammations of the reticulo-endothelial system. 5. Small form fungi were well distributed in the reticulo-endothelial system and a small number of large form ones were seen in desqumative epithelial cells and in necrotic lesions. 6. The large form organisms were polymorphous being 5 to 20 μ in diameter and budding and chain-formation were infrequently observed. They were not appreciably stained with hematoxylin and eosin, but readily demonstrated by Gridley's stain. 7. The presenting pathologic appearances reached their peak in 2 to 3 weeks and then signs of improvement started to develop.
en-copyright=
kn-copyright=

en-aut-name=MimuraKozi
en-aut-sei=Mimura
en-aut-mei=Kozi
kn-aut-name=三村宏二
kn-aut-sei=三村
kn-aut-mei=宏二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=84
cd-vols=
no-issue=9-10
article-no=
start-page=307
end-page=320
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19721030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study on Cell Membrane Structure by Circular Dichroism -Changes in the protein structure after chemical fixation of mitochondrial particles, red cell membrane and bovine serum albumin, as well as a proposal for a cell membrane model-
kn-title=細胞膜構造の円偏光二色性による研究 ミトコンドリヤ，赤血球膜および牛血清アルブミンの化学的固定によるタンパク質構造の変化と細胞膜モデルの考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recently, as the secondary structure of protein structure has come to be distinctly reflected by the ultraviolet circular dichroism (CD) spectrum, an attention has been called to the protein structure of cell membrane by circular dichroism. Lenard and Singer have demonstrated by CD spectrum that the chemical fixation of the cell membrane induces changes in the structure of native red cell membrane, but it is not clear whether or not their conclusion is applicable in common to the membrane of other cells. One of the objects of the present study was to clarify whether the conclusion of Lenard-Singer can be applied generally. For this purpose the author studied changes in the protein structure occurring after the chemical fixation of mitochondrial particles of the rabbit liver and rabbit red cell membrane and bovine serum albumin. It seems quite significant to elucidate the general applicability of their conclusion by clarifying the conformational changes in cell membraneous proteins and other proteins induced by the chemical fixation as it would offer a great parameter to grasp the molecular structure of native cell membrane. The second objective was to elucidate the specific phenomenon, i.e. the cause of red shift of the cell membrane, by the circular dichroism. On the basis of the findings obtained in the observations of those changes occurring in mitochondrial particles, red cell membraines and bovine serum albumin after the chemical fixation, the author proposes here a dynamic cell membrane model as suggested by Seno. The results of the study may be briefly summarized as follows. 1) In the investigation of spectra of the BSA fixed with formaldehyde it has been clearly demonstrated that the aggregation of protein molecules induces the red-shift of the CD spectrum confirming the theory of Lenard-Singer to be valid. 2) Of the findings reported by Lenard-Singer, the facts that chemical fixation induces about 30% (corrected value, 50% ) adhesion of helical structure to the cell membrane, and that the chemical fixation with KMnO(4) brings about the loss of 100% helical structure of the membraneous protein molecules were also demonstrated similarly in the rabbit liver mitochondrial particles and rabbit red cell membrane, indicating that these findings are fairly common in all kinds of cells. 3) However, the extent of conformational changes in the cell membrane induced by the fixation with KMnO(4), OsO(4) or glutaraldehyde as concluded by Lenard-Singer differs from author's own finding. Regarding this problem it seems to be desirable to study further many other kinds of cells. 4) Noting the resemblance of the CD spectrum of BSA fixed with formaldehyde to that of the cell membrane, the author has assumed that the cell membraneous protein molecules are arranged in the form of aggregation. On the basis of this assumption the author has proposed a modified form of the unit membrane model. This modified unit membrane model has the possibility of being readily transposed to a particulate unit model and it has been designed from the perspective of the circular dichroids as against the dynamic membrane model proposed by Seno.
en-copyright=
kn-copyright=

en-aut-name=ItoNobutaka
en-aut-sei=Ito
en-aut-mei=Nobutaka
kn-aut-name=伊藤信隆
kn-aut-sei=伊藤
kn-aut-mei=信隆
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部病理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=1-2
article-no=
start-page=39
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effects of heavy metals on developing sea urchin eggs.
kn-title=ウニ卵の発生に及ぼす重金属の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of heavy metals, such as Hg, Pb, Cu, Cd, As, Sn, Cr, Mn, Ni and Zn on the two developing sea urchin eggs. Temnopleurus and Hemicentrotus were investigated. The results obtained were as follows. 1. The development of fertilized eggs was inhibited when embryos were exposed to 10(-6) M of HgCl(2) and CuCl(2) and to 10(-4) M of CrCl(2) and NiCl(2) in Herbst's artificial seawater from fertilization until the formation of the blastula larva. 2. Chlorate and acetate of heavy metals were dissolved in filtered seawater. The morphological differences of embryo were not observed until the formation of the pluteus larva in the two solutions. Inhibitory effects were observed when embryos were exposed to seawater at concentrations of 10(-7) M of Hg and Cu, to 10(-6) M of Cd, and to 10(-5) M of Pb, Ni and Zn. At a concentration of 10(-4) M of Cd there were no visible effects until the appearance of swimming blastula larva, but larva development was strongly inhibited at time of bonification from pluteus larva, and there was no further later development. In 10(-6) M Hg, Cr, and Ni, the larvae were structural abnonal and shaped like Apollo. In 10(-7) M of Hg exogastrula embryos were produced. 3. Threshold concentration of complete inhibition on the early development of sea urchin embryos was at 10(-6) M of Hg, 10(-5) M of Cu, Cr, Ni, and Zn, 10(-3) M of Mn. In the case of Cd 10(-5) M, complete inhibition didn't occur until the pluteus larva stage. 4. Only additive effects were obtained on the developing sea urchin eggs when two heavy metals were combined in filtered seawater. A high frequency of morphological abnormalities were formed such as exogastrula and Apollo shaped pluteus especially in coupling of Hg and Cu or Cd and Zn. 5. There were no visible effects in filtered sewage from fertilization to the formation of the pluteus larva. When embryos were exposed to acetate salts of Hg, Cu, Cd, and Zn in filtered sewage, there were 10 fold inhibitory effects on development. But formation of skeleton in the pluteus larva was found in filtered sewage containing Cd. 6. Only additive effects were observed on sea urchin embryo when combined with Hg, Cu, Cd, and Zn in filterd sewage. But the abnormalities were decreased in all cases. Inhibition of bonification were reduced in mixture of Cd and filtered sewage.
en-copyright=
kn-copyright=

en-aut-name=MurakamiTetuhide
en-aut-sei=Murakami
en-aut-mei=Tetuhide
kn-aut-name=村上哲英
kn-aut-sei=村上
kn-aut-mei=哲英
aut-affil-num=1
ORCID=

en-aut-name=HayakawaMasashi
en-aut-sei=Hayakawa
en-aut-mei=Masashi
kn-aut-name=早川昌志
kn-aut-sei=早川
kn-aut-mei=昌志
aut-affil-num=2
ORCID=

en-aut-name=FujiiToshitake
en-aut-sei=Fujii
en-aut-mei=Toshitake
kn-aut-name=藤井和武
kn-aut-sei=藤井
kn-aut-mei=和武
aut-affil-num=3
ORCID=

en-aut-name=HaraTakehito
en-aut-sei=Hara
en-aut-mei=Takehito
kn-aut-name=原武仁
kn-aut-sei=原
kn-aut-mei=武仁
aut-affil-num=4
ORCID=

en-aut-name=ItamiYoshiaki
en-aut-sei=Itami
en-aut-mei=Yoshiaki
kn-aut-name=伊丹義明
kn-aut-sei=伊丹
kn-aut-mei=義明
aut-affil-num=5
ORCID=

en-aut-name=KishidaAkira
en-aut-sei=Kishida
en-aut-mei=Akira
kn-aut-name=岸田昭
kn-aut-sei=岸田
kn-aut-mei=昭
aut-affil-num=6
ORCID=

en-aut-name=NisidaIsamu
en-aut-sei=Nisida
en-aut-mei=Isamu
kn-aut-name=西田勇
kn-aut-sei=西田
kn-aut-mei=勇
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一生理学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一生理学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一生理学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一生理学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一生理学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一生理学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一生理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=5-6
article-no=
start-page=689
end-page=695
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19780630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The mutual effects of N0(2) + Cd(2+) and N0(2) + Zn(2+) on the mitochondrial membrane.
kn-title=ミトコンドリア膜に対する亜硝酸イオンとカドミウムイオン,亜鉛イオンの相互作用について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The mutual effects of NaNO(2) + CdCl(2) and NaNO(2) + ZnCl(2) on the oxidative phosphorylation of rat liver mitochondria were examined and following results were obtained. (1) Mixed solution of NaNO(2) and CdCl(2) more decreases respiratory control index at any concentration of NaNO(2) (0-8.6mM) than the index without addition of 4.3μM CdCl(2) respectively. (2) Mixed sollution of CdCl(2) and NaNO(2) more decreases respiratory control index at any concentration of CdCl(2) (0-10μM) than the index without addition of 5mM NaNO(2) respectively. (3) Mixed sollution of NaNO(2) and ZnCl(2) more decreases relative activity of State-3 and dinitrophenol stimulated respiration at any concentration of NaNO(2) (0-8.6mM) than the activity without addition of 4.3μM ZnCl(2) respectively. (4) Mixed sollution of ZnCl(2) and NaNO(2) more decreases relative activity of State-3 and dinitrophenol stimulated respiration at any concentration of ZnCl(2) (0-10μM) than the activity without addition of 5mM NaNO(2) respectively.
en-copyright=
kn-copyright=

en-aut-name=InoueKentaro
en-aut-sei=Inoue
en-aut-mei=Kentaro
kn-aut-name=井上堅太郎
kn-aut-sei=井上
kn-aut-mei=堅太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=11-12
article-no=
start-page=1507
end-page=1510
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19771230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effects of ruthenium red on the K(+) release of mitochondria induced by Cd(2+) and on the binding of Cd(2+) with mitochondrial membrane
kn-title=環境汚染物質(重金属など)の生体膜に対する作用 第4報 カドミウムによるミトコンドリアのK(+)遊出作用及びカドミウムのミトコンドリア膜への結合に対するルテニウムレッドの作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects'of ruthenium red (RR) on the K(+) release induced by Cd(2+) and on the binding of Cd(2+) with mitochondrial membrane were examined and the following results were obtained. 1) The K(+) release of mitochondria induced by Cd(2+) was inhibited by the compounds which had the affinity to the Ca(2+)-binding site, in the order of RR, procaine. 2) Binding of Cd(2+) with mitochondrial membrane was inhibited by RR.
en-copyright=
kn-copyright=

en-aut-name=HasegawaTohoru
en-aut-sei=Hasegawa
en-aut-mei=Tohoru
kn-aut-name=長谷川亨
kn-aut-sei=長谷川
kn-aut-mei=亨
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=11-12
article-no=
start-page=1501
end-page=1505
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19771230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The mutual effects of Cd(2+) and ruthenium red on rat liver mitochondrial energy transfer reaction
kn-title=環境汚染物質(重金属など)の生体膜に対する作用 第3報 カドミウムとルテニウムレッドの相互作用,特にミトコンドリアの酸化的リン酸化反応に対して
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The mutual effects of Cd(2+) and ruthenium red on rat liver mitochondrial energy transfer reaction are described. In results, ruthenium red recovered the depression of the oxidative phosphorylation induced by Cd(2+). Ruthenium red suppressed the K(+) release induced by Cd(2+). As the binding site of the Cd(2+) have other than the binding site of ruthenium red, the site of ruthenium red is greatly related with the inhibitory effect of Cd(2+) and this site is similar to the binding site of Ca(2+).
en-copyright=
kn-copyright=

en-aut-name=HasegawaTohoru
en-aut-sei=Hasegawa
en-aut-mei=Tohoru
kn-aut-name=長谷川亨
kn-aut-sei=長谷川
kn-aut-mei=亨
aut-affil-num=1
ORCID=

en-aut-name=NogamiYusaku
en-aut-sei=Nogami
en-aut-mei=Yusaku
kn-aut-name=野上裕作
kn-aut-sei=野上
kn-aut-mei=裕作
aut-affil-num=2
ORCID=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=11-12
article-no=
start-page=1487
end-page=1494
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19771230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effects of various heavy metal ions (such as Hg(2+), Cd(2+), Cu(2+) and Zn(2+)) on mitochondrial membrane with specific reference to K(+) compart mentation
kn-title=環境汚物(重金属など)の生体膜に対する作用 第1報 各種重金属イオンのミトコンドリア膜に対する作用,特にK(+)区画性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of various heavy metal ions such as Hg(2+), Cd(2+), Cu(2+) and Zn(2+) on mitochondrial membrane were investigated and the following results were obtained; 1) Hg(2+), Cd(2+), Cu(2+) and Zn(2+) released the potassium ion from the mitochondria with the increasing level of an affinity to SH compounds. 2) The release of K(+) by Cd(2+) and Zn(2+) was inhibited in the presence of Mg(2+), but the release of K(+) by Hg(2+) and Cu(2+) was not affected. 3) In the presence of ImM DTT, the release of K(+) by all of these metal ions was completely inhibited.4) The K+ release by Hg(2+) and Cu(2+) was inhibited by DTNB or PCMB which bound prefencially the thiol component of membrane protein, but the release by Cd(2+) and Zn(2+) was not inhibited by these reagents. 5) The release of K(+) decoupled the oxidative phosphorylation by treatment of the heavy metal ions.
en-copyright=
kn-copyright=

en-aut-name=HasegawaTohoru
en-aut-sei=Hasegawa
en-aut-mei=Tohoru
kn-aut-name=長谷川亨
kn-aut-sei=長谷川
kn-aut-mei=亨
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=1-2
article-no=
start-page=251
end-page=256
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19780228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The mutual effects of Cd(2+), ruthenium red and Ca(2+) on the mitochondrial latent ATPase activity
kn-title=ミトコンドリアのATPase活性に対するカドミウム,ルテニウムレッド及びカルシウムの相互作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The mutual effects of Cd(2+), ruthenium red and Cd(2+) on the rat liver mitochondrial latent ATPase activity were studied and the following results were obtained. (1) The mitochondrial latent ATPase activity was stimulated by Cd(2+), and higher concentration of Cd(2+) added to the reaction mixture showed higher ATPase activity. (2) The ATPase activity induced by Cd(2+) was inhibited by ruthenium red, having the high affinity for the Ca(2+) -binding site of mitochondria. (3) The ATPase activity induced by Cd(2+) was also inhibited by Ca(2+). (4) In conclusion, the site of mitochondria, on which Cd(2+) activates latent ATPase, will be related with the Ca(2+) -binding site of mitochondria.
en-copyright=
kn-copyright=

en-aut-name=KenmotsuKatashi
en-aut-sei=Kenmotsu
en-aut-mei=Katashi
kn-aut-name=劒持堅志
kn-aut-sei=劒持
kn-aut-mei=堅志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=3
article-no=
start-page=195
end-page=198
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=JPN (Japan Pancreas Society) guidelines for the management of pancreatic cancer
kn-title=膵癌診療ガイドライン―内科治療の総論について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HiraoKen
en-aut-sei=Hirao
en-aut-mei=Ken
kn-aut-name=平尾謙
kn-aut-sei=平尾
kn-aut-mei=謙
aut-affil-num=1
ORCID=

en-aut-name=KawamotoHirofumi
en-aut-sei=Kawamoto
en-aut-mei=Hirofumi
kn-aut-name=河本博文
kn-aut-sei=河本
kn-aut-mei=博文
aut-affil-num=2
ORCID=

en-aut-name=YamamotoKazuhide
en-aut-sei=Yamamoto
en-aut-mei=Kazuhide
kn-aut-name=山本和秀
kn-aut-sei=山本
kn-aut-mei=和秀
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=11-12
article-no=
start-page=1467
end-page=1473
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19791230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The influence of cadmium on adenine nucleotide concentration and the effect of lanthanium on K(+)-release of rat liver mitochondria induced by cadmium
kn-title=カドミウムの生体作用に対する実験的研究 第1報 ラット肝ミトコンドリアのヌクレオタイドに対するカドミウムの作用,及びK(+)-遊出に対するカドミウムとランタンの相互作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The influence of cadmium (Cd(2+)) on adenine nucleotide concentration in a reaction mixture consisting of rat liver mitochondria and ADP was studied using high performance liquid chromatography. The results were as follows: An increase in AMP concentration was brought about by the addition of Cd(2+). This increase in AMP concentration occurred in parallel with increase in Cd(2+) concentration. The appearance of AMP was thought to be due to an ATPase reaction and an adenylate kinase reaction stimulated by Cd(2+) although further studies on the adenylate kinase reaction stimulated by Cd(2+) are needed. An increase in AMP may influence metabolism via glycolysis. As lanthanium (La(3+)) is related to Ca(2+)-binding sites, the effect of La(3+) on the K(+)-release of rat liver mitochondria induced by Cd(2+) was also studied. The results were: K(+)-release induced by Cd(2+) was inhibited by La(3+). The Cd(2+)-binding site was thought to be related to the Ca(2+) carrier of mitochondria.
en-copyright=
kn-copyright=

en-aut-name=NogamiYusaku
en-aut-sei=Nogami
en-aut-mei=Yusaku
kn-aut-name=野上祐作
kn-aut-sei=野上
kn-aut-mei=祐作
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=ミトコンドリア
kn-keyword=ミトコンドリア
en-keyword=ヌクレオタイド
kn-keyword=ヌクレオタイド
en-keyword=カドミウム
kn-keyword=カドミウム
en-keyword=K(+)-遊出
kn-keyword=K(+)-遊出
en-keyword=ランタン
kn-keyword=ランタン
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=11-12
article-no=
start-page=1447
end-page=1454
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19791230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Oxidative phosphorylation of rat liver and kidney mitochondria after Cd intoxication and the preventive effect of Mg
kn-title=環境汚染物質(重金属など)の生体膜に対する作用 第5報 Cd投与ラットにおける肝,腎ミトコンドリアの酸化的リン酸化反応及びMg投与の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Experimental acute intoxication from cadmium chloride in the rat was studied with specific reference to change in the activity of mitochondrial oxidative phosphorylation in the liver and kidney. Various concentrations of cadmium chloride (2.5, 5.0, 10.0 mg/Kg) were given by intraperitoneal injection. Two hours after cadmium injection, the activity of liver and kidney mitochondrial oxidative phosphorylation had decreased, suggesting that cadmium uncoupled oxidative phosphorylation in liver and kidney mitochondria. A dose response relationship of cadmium uncoupling was observed in liver mitochondria, but was not observed in kidney mitochondria indicating that kidney mitochondria were more sensitive to cadmium than liver mitochondria were. A single injection of 250 mg/Kg of magnesium chloride prevented the uncoupling action of cadmium in liver mitochondria but not in kidney mitochondria. Magnesium did not prevent the uncoupling action of mercury chloride in liver or kidney mitochondria. The preventive action of magnesium chloride was evident in in vitro liver mitochondria but not in in vitro kidney mitochondria. The effect of magnesium on cadmium action was discussed.
en-copyright=
kn-copyright=

en-aut-name=HasegawaTohoru
en-aut-sei=Hasegawa
en-aut-mei=Tohoru
kn-aut-name=長谷川亨
kn-aut-sei=長谷川
kn-aut-mei=亨
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=カドミウム
kn-keyword=カドミウム
en-keyword=肝及び腎ミトコンドリア
kn-keyword=肝及び腎ミトコンドリア
en-keyword=酸化的リン酸化
kn-keyword=酸化的リン酸化
en-keyword=マグネシウム
kn-keyword=マグネシウム
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=11-12
article-no=
start-page=1083
end-page=1090
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19811230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Induction of metallothionein synthesis in the liver of rats by X-ray irradiation
kn-title=X線照射によるラット肝メタロチオネインの誘導
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Experiments were carried out on the rat liver metallothionein induced by X-ray irradiation. The following results were obtained. 1) The metallothionein content of liver cells increased for a certain time after X-ray irradiation. SOD activity showed an upward trend in accordance with the increasing metallothionein. 2) The increase in metallothio-nein content induced kept in certain level with the time course after irradiation. 3) This metallothionein contains Zn(2+), and also has the ability to bind Cd(2+). 4) The SDS-PAGE pattern indicated that this metallothionein consists of two subunits having molecular weights of 11,000 and 9,000 respectivily. Also this metallothionein showed the same electrophoretic properties as that of Zn(2+)-induced metallothionein.
en-copyright=
kn-copyright=

en-aut-name=AonoKaname
en-aut-sei=Aono
en-aut-mei=Kaname
kn-aut-name=青野要
kn-aut-sei=青野
kn-aut-mei=要
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院中央放射線部
en-keyword=X線照射
kn-keyword=X線照射
en-keyword=メタロチオネイン
kn-keyword=メタロチオネイン
en-keyword=SOD活性
kn-keyword=SOD活性
en-keyword=SDS-PAGE
kn-keyword=SDS-PAGE
END

start-ver=1.4
cd-journal=joma
no-vol=96
cd-vols=
no-issue=3-4
article-no=
start-page=359
end-page=376
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19840430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Levels and distribution of toxic and essentiol metals in biological samples collected in Okayama prefecture
kn-title=生体中のマンガン,鉄,亜鉛,銅,鉛,水銀,カドミウムなどの濃度分布
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper deals with the levels and distribution of manganese (Mn), zinc (Zn), iron (Fe), copper (Cu), lead (Pb), marcury (Hg), cadmium (Cd) and other trace metals in 3 kinds of biological samples relevant to the food chain. Eightly-eight human whole blood samples were taken from 20-59 year old normal adult subjects (57 males and 31 females) in Okayama Prefecture, and the heavy metal concentrations were mesured with a flame or flameless atomic absorption spectrophotometer. The order by level of heavy metals in the whole blood was Fe, Mg, Ca, Zn, Cu, Pb, Mn and Cd. The analytical values of each metal approximated a log-normal distribution. The levels of Fe, Mg and Zn were higher in males than in females, while that of Cu was higher in females high correlation coefficients were obtained between Pd-Cd, Pb-Cd, Cd-Mn and Cd-Fe. The levels of Fe and Zn in males had a negative correlation with thier age. On the other hand, that of Ca and Mg in females had a positive correlation. The heavy metal levels in the fethers of crows were examined as a biological index of heavy metal contamination. The order of heavy metals in feathers was: Zn, Fe, Mn, Pb, Hg and Cd. The concentrations of Pb and Mn were from 3 to 10 times higher in the feathers of crows than in human hair. The concentraiton levels of Cd and Cu were higher in the southern part than in the northern part of Okayama Prefecture. There were significant regional differences in the levels of Pb, Cd and Cu. The order of heavy metals in oyster was Zn, Cu, Mn, As, Ni, Cd, Pb, Se and Hg. The concentration of Zn and Cu had a significant correlation with the size of the oyster. The order of biological concentration was; Zn (22.3×10), Se, Cu, Mn, As, Ni and Pb (7.75×10(3)-0.22×10(3))
en-copyright=
kn-copyright=

en-aut-name=MoritaKeijiro
en-aut-sei=Morita
en-aut-mei=Keijiro
kn-aut-name=森田啓次郎
kn-aut-sei=森田
kn-aut-mei=啓次郎
aut-affil-num=1
ORCID=

en-aut-name=OgataMasana
en-aut-sei=Ogata
en-aut-mei=Masana
kn-aut-name=緒方正名
kn-aut-sei=緒方
kn-aut-mei=正名
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=指標生物
kn-keyword=指標生物
en-keyword=生体中金属
kn-keyword=生体中金属
en-keyword=人血液
kn-keyword=人血液
en-keyword=カラス
kn-keyword=カラス
en-keyword=カキ
kn-keyword=カキ
END

start-ver=1.4
cd-journal=joma
no-vol=96
cd-vols=
no-issue=3-4
article-no=
start-page=327
end-page=339
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19840430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on biochemical effects of manganese I; Atomospheric levels and phsicochemical properties of manganese in the enviroment
kn-title=マンガンの生体影響に関する研究 第1編 溶接作業場及び居住地域におけるマンガンの性状と気中濃度
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the present study, the author examined the physicochemical properties and the atomospheric levels of manganese and other heavy metals in the suspended particulate matter of a welding workshop and a residential area neighboring an iron works. α-Fe(2)O(3) and Fe(3)O(4) were the main components of the suspended particulate matter collected in the atomosphere around both areas. The total suspended particulate matter of the welding process (welding TSP) also contained MnFe(2)O(4) formed from Fe(3)O(4) by exchange of Fe with Mn, metalic Mn and an alloy from of Mn-Fe. These findings were obtained by X-ray diffractometry. Observation through the electron microscope showed the presence of fin particles (0.5-1.5μm) in welding TSP, and attention should be given hazards. The concentration of the metals in the welding TSP was about 10 to 30 times higher than that in the covering materials of the welding rods. Exposure levels of manganese in the welding workshop at a breathing zone ranged from 0.4 to 1.0μg/m(3) and the levels were reduced to one tenth by using a welding mask. Levels of manganese have decreased from a maximum median levels of 0.24μg/m(3) in 1971 to 0.15μg/m(3) in 1981. The order of content of the metals in the paticulate matter was: Fe, Cu, Zn, Pb, Mn, V, Ni, and Cd.
en-copyright=
kn-copyright=

en-aut-name=MoritaKeijiro
en-aut-sei=Morita
en-aut-mei=Keijiro
kn-aut-name=森田啓次郎
kn-aut-sei=森田
kn-aut-mei=啓次郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=マンガン気中濃度
kn-keyword=マンガン気中濃度
en-keyword=化学形態
kn-keyword=化学形態
en-keyword=粒径
kn-keyword=粒径
en-keyword=溶接作業場
kn-keyword=溶接作業場
en-keyword=居住地域
kn-keyword=居住地域
END

start-ver=1.4
cd-journal=joma
no-vol=99
cd-vols=
no-issue=3-4
article-no=
start-page=321
end-page=336
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=19870430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Serum and urinary β(2)-microglobulin levels of monkeys orally exposed to cadmium under malnutritional conditions
kn-title=カドミウム経口投与サルの血清および尿β(2)ミクログロブリンの変動 ―栄養要因の影響―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Urinary and serum cadmium levels as well as cadmium contents in kidneys of female rhesus monkeys given a cadmium (Cd)-containing diet and subjected to malnutrition were slightly elevated during the experimental period of 7 years. Particulary, greater excretion of cadmium in urine, elevation of serum cadmium and greater accumlation of cadmium in kidneys were observed early in the malnutritional groups (groups No.6, 7 and 8) as compared to the basal diet group (group No.5). One monkey in the low-nutritional and low-vitamin D group fed with Cd (group No.8) accumulated over 1000μg of Cd per g wet weight in the kidneys even at 36 months. No remarkable changes in serum β(2)-microglobulin were observed in the Cd-treated groups (group No.5 to No.8) nor in the non-Cd treated groups (groups No.1 to No.4) during the experimental period. Although no significant leak of urinary β(2)-microglobulin was seen among the basal diet group fed with Cd (group No.5), the basal diet and low-vitamin D group fed with Cd (group No.7) and the non-Cd treated group (groups No.1 to No.4), much urinary β(2)-microglobulin began to leak at 36 months in the low-nutritional and low-vitamin D group fed with Cd (group No.8) and at 48 months in the low-nutritional group fed with Cd (group No.6). The high levels of urinary β(2)-microglobulin seen in group No.8 reverted to normal with medical treatment, and the high levels observed in group No.6 sometimes decreased. These observations suggest mild renal dysfunction among the malnutritioned monkeys (groups No.6 and No.8) exposed to Cd.
en-copyright=
kn-copyright=

en-aut-name=OtakiNoriko
en-aut-sei=Otaki
en-aut-mei=Noriko
kn-aut-name=小瀧規子
kn-aut-sei=小瀧
kn-aut-mei=規子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=Cadmium
kn-keyword=Cadmium
en-keyword=Monkeys
kn-keyword=Monkeys
en-keyword=Serum and urinary Beta-2-Microglobulin
kn-keyword=Serum and urinary Beta-2-Microglobulin
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1973
dt-pub=19730720
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Effect of Temperature Gradient on Ultrasonic Attenuation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effect of temperature gradient on ultrasonic attenuation is estimated based upon the simple phenomenological theory, and it being found that the
attenuation coefficient for a CdS crystal is 0.76 dB/cm at temperature gradient 100 K/cm.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiiTadao
kn-aut-sei=Ishii
kn-aut-mei=Tadao
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electronics, Electrophysics
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=1
article-no=
start-page=47
end-page=52
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=19710901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Solubility of Sulphur in a Cadmium Borate Glass and SomeProperties of the Sulphur Containing Glasses
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The glass forming limit by substitution of CdS for CdO in a CdO-B(2)0(3) glass was determined by chemical analysis. When x CdS-(60-x)CdO-40B(2)0(3) nominal mixtures in weight ratio were heated at 1100°C in flowing nitrogen gas for 1/2 hour, about 40~50% of mixed CdS and 10-15% of the mixed CdS were evaporated. The limit of nominal composition for glass forming was 10CdS-50CdO-40B(2)0(3) and the corresponding virtual composition after the above heat treatment was found to be 4.9CdS-46.4CdO-48.7B(2)O(3). Further addition of CdS made the melt devitrefied with CdS precipitation. D.C. conductivity measurements revealed that the current density was not linear with respect to the applied voltage, but the resistivity ranged around 10(12)Ω･cm for 4.1CdS-48.8CdO-47.1B(2)O(3) (virtual composition) glass and around 10(11.5)Ω·cm for 4.9CdS-46.4CdO-48.7B(2)O(3) glass. These sulphur containing glasses did not show photoconduction, although CdS-precipitated materials showed slight photoconductivity when disposed in ultra violet radiation. Apparent dielectric constant and tan 8 were also measured as a function of frequency, revealing a moderate dispersion in the CdS-precipitated glasses.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TakahashiKatsuaki
kn-aut-sei=Takahashi
kn-aut-mei=Katsuaki
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=GotoYasumasa
kn-aut-sei=Goto
kn-aut-mei=Yasumasa
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Industrial Chemistry

affil-num=2
en-affil=
kn-affil=Department of Industrial Chemistry
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=1
article-no=
start-page=39
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1968
dt-pub=19680901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Binding Energy between a Vacancy and an Atom of Third Element and their Effects on the Initial Aging of Aluminium Binary Alloys
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Al-Zn, Al-Ag and Al-Cu base ternary alloys were studied by measurement of electrical resistivity. An approximate methods to estimate the binding energy between an atom of a third element and a vacancy was derived. The binding energy between a vacancy and an atom of Cu, Ag, Au, Be, Ca, Cd, In, Si, Ti, Ge, Zr, Sn, Pb or Mn was estimated to be <0.23, 0.25,> 0.35, 0.28, 0.27, 0.32, 0.39, 0.28, 0.30, 0.33, 0.33, 0.43, >0.38 or <0.23 (±0.05) eV, respectively. The results may be summarized as follows: (I) The ratio of the time required to reach the maximum electrical resistivity in isothermal aging curves of the Al-Zn-X or Al-Ag-X ternary alloy to that in the Al-Zn or Al-Ag binary alloy may be inversely proportional to the ratio of the concentration of vacancies bound to Zn or Ag atoms immediately after quenching in the ternary alloy to that in the binary alloy. And also the ratio of initial rate of clustering for AI-Cu-X ternary alloy to that in the binary alloy may be inversely proportional to the ratio of the concentration of vacancies bound to Cu atoms immediately after quenching in the ternary alloy to that in the binary alloy. It is possible to deduce the binding energy
between an atom of X element and a vacancy using this relations. (2) The effect of the valence of the solute element on the binding energy between an atom of a third element and a vacancy was remarkable. (3) The effect of the radius of an atom of the solute element on the binding energy is also observed, but this effect is smaller than that of the valence.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OhtaMatsuo
kn-aut-sei=Ohta
kn-aut-mei=Matsuo
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=HashimotoFumio
kn-aut-sei=Hashimoto
kn-aut-mei=Fumio
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TanimotoTadashi
kn-aut-sei=Tanimoto
kn-aut-mei=Tadashi
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Industrial Science

affil-num=2
en-affil=
kn-affil=Department of Industrial Science

affil-num=3
en-affil=
kn-affil=Department of Iudusttial Science
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=1
article-no=
start-page=138
end-page=147
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1966
dt-pub=19660331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Binding Energies between a Vacancy and a Cadmium, Indium or Tin Atom in Al-10wt % Zn, Al-3.0wt % Ag and Al-3.0wt % Cu Alloys
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The changes of electrical resistivity of several alloys, that is, Al-10wt % Zn, Al-10wt % Zn-0.01wt % Cd, Al-10wt % Zn-0.01wt % In, Al-10wt % Zn-0.01wt % Sn, Al-3.0wt % Ag, Al-3.0wt % Ag-0.01wt % Cd, Al-3.0wt % Ag-0.01wt % In, Al3.0wt %
Ag-0.0lwt % Sn, Al-3.0wt % Cu, Al-3.0wt % Cu-0.0lwt % Cd and Al-3.0wt % Cu-0.01wt % In, during isothermal aging after quenching were measured. The interactions between a vacancy and a cadmium, indium or tin atom in Al-10wt % Zn, Al-3.0wt % Ag and Al-3.0wt % Cu alloys were estimated. Binding energies obtained for Al-Zn, Al-Ag and Al-Cu base ternary alloys agree within experimental accuracy with each other.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OhtaMutsuo
kn-aut-sei=Ohta
kn-aut-mei=Mutsuo
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=HashimotoFumio
kn-aut-sei=Hashimoto
kn-aut-mei=Fumio
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TanimotoTadashi
kn-aut-sei=Tanimoto
kn-aut-mei=Tadashi
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Industrial Science

affil-num=2
en-affil=
kn-affil=Department of Industrial Science

affil-num=3
en-affil=
kn-affil=Department of Industrial Science
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=2
article-no=
start-page=93
end-page=97
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヒト血清リポタンパク質とシクロデキストリンのアガロースゲル内における相互作用
kn-title=Human serum lipoprotein-cyclodextrin interaction in agarose gel
en-subtitle=
kn-subtitle=
en-abstract=シクロデキストリンは低分子量の環状オリゴ糖で, リポタンパク質と複合体を形成する｡シクロデキストリンを使用した電気泳動による血清リポタンパク質サブクラスの分離の可能性を明らかにするために, リポタンパク質とシクロデキストリンとの泳動用ゲル内での相互作用について検討をおこなった｡その結果,α-CDとβ-CDの2種類のCDをアガロースゲルに添加し,このゲルを泳動用支持体として等電点電気泳動をおこなったところ,apoB含有リポタンパク質が数分画分離された｡したがって,ゲル内へのシクロデキストリンの適正な添加条件が設定できるならば,apoB含有リポタンパク質サブクラスの分離が可能となることが示唆された｡
kn-abstract=Cyclodextrins (CDs) are cyclic oligosaccharides with low molecular weight. They have been known to bind to some serum lipoproteins and to form complexes. To elucidate whether each serum lipoprotein subclass could be separated by electrophoresis using CDs, we performed preliminary experiment, in which lipoprotein-CDs interaction was examined on electrophoresis with agarose gel. When the supporting agarose gel containing both α-CD and β-CD was prepared and was applied to isoelectric focusing for fractionating serum lipoproteins, apoB lipoproteins were found to be clearly separated into several fractions on this electrophoresis. This finding suggested that apoB lipoprotein may be detected as isolated form by arranging amounts of added CDs.
en-copyright=
kn-copyright=

en-aut-name=IchimuraMitsuko
en-aut-sei=Ichimura
en-aut-mei=Mitsuko
kn-aut-name=一村光子
kn-aut-sei=一村
kn-aut-mei=光子
aut-affil-num=1
ORCID=

en-aut-name=TohgeHiroko
en-aut-sei=Tohge
en-aut-mei=Hiroko
kn-aut-name=唐下博子
kn-aut-sei=唐下
kn-aut-mei=博子
aut-affil-num=2
ORCID=

en-aut-name=SakiyamaJunko
en-aut-sei=Sakiyama
en-aut-mei=Junko
kn-aut-name=崎山順子
kn-aut-sei=崎山
kn-aut-mei=順子
aut-affil-num=3
ORCID=

en-aut-name=MoriShuji
en-aut-sei=Mori
en-aut-mei=Shuji
kn-aut-name=森秀治
kn-aut-sei=森
kn-aut-mei=秀治
aut-affil-num=4
ORCID=

en-aut-name=ItoSekiko
en-aut-sei=Ito
en-aut-mei=Sekiko
kn-aut-name=伊藤昔子
kn-aut-sei=伊藤
kn-aut-mei=昔子
aut-affil-num=5
ORCID=

en-aut-name=NakataYasunari
en-aut-sei=Nakata
en-aut-mei=Yasunari
kn-aut-name=中田安成
kn-aut-sei=中田
kn-aut-mei=安成
aut-affil-num=6
ORCID=

en-aut-name=EndoHiroshi
en-aut-sei=Endo
en-aut-mei=Hiroshi
kn-aut-name=遠藤浩
kn-aut-sei=遠藤
kn-aut-mei=浩
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=2
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=3
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=4
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=5
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=6
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=7
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科
en-keyword=血清apoB含有リポタンパク質 (serum apoB lipoprotein)
kn-keyword=血清apoB含有リポタンパク質 (serum apoB lipoprotein)
en-keyword=シクロデキストリン (cyclodextrin)
kn-keyword=シクロデキストリン (cyclodextrin)
en-keyword=等電点電気泳動 (isoelectric focusing (IEF))
kn-keyword=等電点電気泳動 (isoelectric focusing (IEF))
en-keyword=agarose gel
kn-keyword=agarose gel
END

start-ver=1.4
cd-journal=joma
no-vol=67
cd-vols=
no-issue=
article-no=
start-page=75
end-page=78
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=199611
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Gastro-biliary motility in patients with non-ulcer dyspepsia
kn-title=上腹部不定愁訴患者の胃･胆嚢運動に関する研究
en-subtitle=
kn-subtitle=
en-abstract=Subjective symptoms are quite similar between cystic duct syndrome (CDS) and non-ulcer dyspepsia (NUD) : epigastralgia, hypochondralgia and vague complaints in the
upper part of the abdomen. Recently, there has been several reports suggesting that the cause of these disorders is postprandial dysmotility in the gallbladder and stomach. However, there has been no report suggesting
incoordination of postprandial gastrobilialy motility as the cause of tha above mentioned complaints in these disorders. The aim of this study was to define the difference of postprandial gastrobiliary motility between
patients with NUD and controls. Eight patients with NUD and 10 controls were studied. Gastric emptying time of liquid meal and gallbladder contraction were measured, simultaneously. There was no significant difference between study patients and controls when gastric emptying time and gallbladder contraction rate were compared in isolation. However, when these two parameters were assessed in combination, gastric emptying time was linearly correlated with minimum ballbladder contraction time in controls but not in patients. We conclude that the incoordination between gastric emptying and minimal gallbladder contraction may be one of the major causes of the symptoms in NUD.
kn-abstract=現在,上腹部不定愁訴の原因は特定されていない｡その原因を解明するため,上腹部不定愁訴患者8人と健常対照者10人に対して液体食の胃排出能と,食事負荷による胆嚢収縮能を測定した｡胃排出時間,胆嚢収縮能はいずれも両者に有意な差は認められなかった｡健常対照者では胃排出時間と胆嚢収縮時間に有意な相関関係が認められたが,上腹部不定愁訴群では相関関係は認められなかった｡上腹部不定愁訴の原因として胃･胆嚢協調運動障害の存在が示唆
された。
en-copyright=
kn-copyright=

en-aut-name=MizushimaTakaaki
en-aut-sei=Mizushima
en-aut-mei=Takaaki
kn-aut-name=水島孝明
kn-aut-sei=水島
kn-aut-mei=孝明
aut-affil-num=1
ORCID=

en-aut-name=YamamotoRyoichi
en-aut-sei=Yamamoto
en-aut-mei=Ryoichi
kn-aut-name=山本良一
kn-aut-sei=山本
kn-aut-mei=良一
aut-affil-num=2
ORCID=

en-aut-name=MatsumuraNaoki
en-aut-sei=Matsumura
en-aut-mei=Naoki
kn-aut-name=松村直樹
kn-aut-sei=松村
kn-aut-mei=直樹
aut-affil-num=3
ORCID=

en-aut-name=ChowdhuryRiaz
en-aut-sei=Chowdhury
en-aut-mei=Riaz
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatoTadahiro
en-aut-sei=Kato
en-aut-mei=Tadahiro
kn-aut-name=加藤匡宏
kn-aut-sei=加藤
kn-aut-mei=匡宏
aut-affil-num=5
ORCID=

en-aut-name=OchiKoji
en-aut-sei=Ochi
en-aut-mei=Koji
kn-aut-name=越智浩二
kn-aut-sei=越智
kn-aut-mei=浩二
aut-affil-num=6
ORCID=

en-aut-name=TanakaJuntaro
en-aut-sei=Tanaka
en-aut-mei=Juntaro
kn-aut-name=田中淳太郎
kn-aut-sei=田中
kn-aut-mei=淳太郎
aut-affil-num=7
ORCID=

en-aut-name=HaradaHideo
en-aut-sei=Harada
en-aut-mei=Hideo
kn-aut-name=原田英雄
kn-aut-sei=原田
kn-aut-mei=英雄
aut-affil-num=8
ORCID=

en-aut-name=YokotaSatoshi
en-aut-sei=Yokota
en-aut-mei=Satoshi
kn-aut-name=横田聡
kn-aut-sei=横田
kn-aut-mei=聡
aut-affil-num=9
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=10
ORCID=

en-aut-name=MifuneTakashi
en-aut-sei=Mifune
en-aut-mei=Takashi
kn-aut-name=御舩尚志
kn-aut-sei=御舩
kn-aut-mei=尚志
aut-affil-num=11
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科

affil-num=2
en-affil=
kn-affil=岡山大学医学部第二内科

affil-num=3
en-affil=
kn-affil=岡山大学医学部臨床検査医学

affil-num=4
en-affil=
kn-affil=岡山大学医学部臨床検査医学

affil-num=5
en-affil=
kn-affil=岡山大学医学部臨床検査医学

affil-num=6
en-affil=
kn-affil=岡山大学医学部臨床検査医学

affil-num=7
en-affil=
kn-affil=岡山大学医学部臨床検査医学

affil-num=8
en-affil=
kn-affil=岡山大学医学部臨床検査医学

affil-num=9
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=10
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=11
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科

affil-num=12
en-affil=
kn-affil=岡山大学医学部附属病院三朝分院内科
en-keyword=胃運動 (Gastric motility)
kn-keyword=胃運動 (Gastric motility)
en-keyword=胆嚢運動 (Biliary motility)
kn-keyword=胆嚢運動 (Biliary motility)
en-keyword=不定愁訴 (indefinite complaint)
kn-keyword=不定愁訴 (indefinite complaint)
END

start-ver=1.4
cd-journal=joma
no-vol=49
cd-vols=
no-issue=7
article-no=
start-page=529
end-page=536
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=2000
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Determination of trace elements in natural water samples by air-segmented flow-injection/ICP-MS after preconcentration with a chitosan-based chelating resin
kn-title=キトサンキレート樹脂前処理法を用いる空気分節試料導入/誘導結合プラズマ質量分析法による天然水中の多元素同時定量
en-subtitle=
kn-subtitle=
en-abstract=Ultratrace elements in natural water samples were determined simultaneously by air-segmented flow-injection/inductively coupled plasma-mass spectrometry(SFI/ICP-MS).A small volume of the sample solutions(80μl) was introduced into a nebulizer by an air-segmented flow-injection(SFI) system, and a maximum of fifteen elements were measured during each run.A chitosan-based chelating resin containing functional groups of iminodiacetate was used to separate and enrich analyte metal ions.A 50-fold preconcentration using 50ml of sample solutions was achieved by the proposed method, where 1ml of 0.1M nitric acid was added to residues after drying the chelating column effluent.At pH6, several heavy metals(Fe, Ni, Co, Cu, Zn, Ag, Cd, Pb and U) and rare earth elements(REEs) were quantitatively retained on the chelating resin column, whereas alkali and alkaline earth metals were eluted from the column by rinsing with 5ml of a 0.2M ammonium acetate solution.Metals adsorbed on the chelating resin column were recovered by elution with 10ml of 1M nitric acid.The proposed method was applied to the determination of trace elements in several natural water samples, such as river water and mineral drinking water.
kn-abstract=本法では,各種天然水中の極微量金属成分を同時定量する目的で空気分節試料導入/ICP-MSシステムを用いて,微少量試料(数十μl)を前処理せずにネブライザーに送り込み,多数の金属成分の定量が可能であった。共存主成分による質量干渉を受ける一部遷移金属や直接試料導入では感度の足りない元素については,イミノ二酢酸型キトサンキレート樹脂充填カラムによる分離·濃縮操作の併用によって更に信頼性の高いデータが得られることが分かった。前処理においては,体積1mlのミニカラムを用いて50mlの溶液試料から50倍濃縮を行い,試料·試薬·廃液すべてを少量化することができた。本ICP-MSシステムでは試料導入量は80μlで十分であり,1mlでも数回繰り返し測定が可能で,しかも多元素同時分析ができた。確立した分析法を用いて河川水や市販のミネラルウォーターに応用し,希土類を含め45種の微量元素の定量が可能となった。
en-copyright=
kn-copyright=

en-aut-name=NinomiyaTakahiko
en-aut-sei=Ninomiya
en-aut-mei=Takahiko
kn-aut-name=二宮崇彦
kn-aut-sei=二宮
kn-aut-mei=崇彦
aut-affil-num=1
ORCID=

en-aut-name=LeeKyue-Hyung
en-aut-sei=Lee
en-aut-mei=Kyue-Hyung
kn-aut-name=李啓熒
kn-aut-sei=李
kn-aut-mei=啓熒
aut-affil-num=2
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=3
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学理学部化学科

affil-num=2
en-affil=
kn-affil=岡山大学理学部化学科

affil-num=3
en-affil=
kn-affil=岡山大学理学部化学科

affil-num=4
en-affil=
kn-affil=岡山大学理学部化学科
en-keyword=ICP-MS
kn-keyword=ICP-MS
en-keyword=segmented-flow injection
kn-keyword=segmented-flow injection
en-keyword=chelating resin
kn-keyword=chelating resin
en-keyword=chitosan
kn-keyword=chitosan
en-keyword=iminodiacetic functional group
kn-keyword=iminodiacetic functional group
en-keyword=natural waters
kn-keyword=natural waters
en-keyword=preconcentration
kn-keyword=preconcentration
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=89
end-page=94
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Design of vehicle instrumental panel for older adults 
- Effects of viewing distance, display from, and switch arrangement on secondary task performance -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of age, viewing distance, arrangement of switches and display form on performance to design of display and control systems friendry to older adults were discussed. A dual-task experimemt was conducted in which the primary task was first-irder tracking. The secondary tasks included control of an air conditioner, the operation of a radio, and the operation of a CD/MD, by means of a steering wheel mounted swich. The switch was either vertical or cross arrangement. In both-hands switch arrangement condition, the operation was carried out with two hands using both left vertical switch and right cross switch. In one-hand swith arrangement condition, the operation was carried out with only one hand using either left or right cross switch. The display was arranged in front of a participant. The display form was either left or right display. The viewing distance conditions were 60, 80, and 100cm. When the right display form was used, both one-hand (using only right cross switch) were selected. When the left display form was used, both one-hand (using only left cross swith) and two-hand arrangements (using both left vertical and right cross switch) were selected. As predicted, age affected the performance measures ( percentage correct, task completion time, and tracking error). The viewing distance also affected performance (percentage correct), Both display form and switch arrangement also affected performance (task completion time). Such results should be taken into account when designing display and control systems in man-vehicle systems.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=YamaguchiSatoshi
en-aut-sei=Yamaguchi
en-aut-mei=Satoshi
kn-aut-name=山口智司
kn-aut-sei=山口
kn-aut-mei=智司
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=83
end-page=88
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of Automotive Control-Display System by means of MentalWorkload
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of age, task difficulty on performance and mental workload were discussed in order to provide design guideline of automobile display that is friendly to older adults from the viewpoints of mental attention, speed and accuracy. A dual-task experiment was conducted in which the
primary task was first order tracking. The secondary
tasks included selection of function (easy condition),
and control of an air conditioner, the operation of a
radio, and the operation of a CD/MD (difficult condition), by means of a steering wheel mounted switch. The display was arranged in front of a participant. Age affected the performance measures and heart rate variability (HRV). As for the young adults, the task completion time did not differ significantly among easy and difficult (one-, two-, and three-layered) conditions. The performance of older
adults was affected by task difficulty. The HRV
measures such as CV (coefficient of variance) and
RRV8-3 during the task showed different tendency
between young and older adults. As for the young
group, the HRV measures did not differ significantly
between the four task levels (easy, one-, two-, and
three-layered). This confirmed that the task difficulty
did not induce different mental workload to young
adults. On the other hand, as for the older adults, the
HRV measures tended to increase with the increase of
task difficulty. Although it appears that mental
workload was lessened with the increase of task
difficulty, such an interpretation was contradictory to
the results on performance. This phenomenon was
interpreted that the difficult task condition was
overloaded for older adults, and was beyond the limit
of mental effort. Based on the results, it could be
concluded that the difficult task condition is not
proper for older adults.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1301
end-page=1310
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on chemotherapy for small cell lung cancer Part 1. Reversal of adriamycin resistance in human small cell lung cancer cells in culture
kn-title=肺小細胞癌の化学療法に関する研究　第1編　Adriamycin 耐性ヒト肺小細胞癌細胞株の耐性解除に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using adriamycin-resistant human small cell lung cancer cells (SBC-3/ADM), which were 30-fold more resistant to adriamycin than the parent cells (SBC-3), the ability of membrane-modifying agents to overcome the drug resistance was analyzed by a soft agar clonogenic assay. SBC-3/ADM was not circumvented by hyperthermia of 42℃ or amphotericin B at a concentration of 50μ M. Verapamil did not enhance the adriamycin cytoxicity in the SBC-3 cells at a concentration of 10μ M, but a 3.2-fold increase in the drug effect occurred in the SBC-3/ADM cells in terms of LD(70). The efflux of intracellular [H(3)] daunomycin from SBC-3/ADM cells was inhibited by verapamil, while the inhibition did not occur in the parent cells. Furthermore, quinidine (50μ M), cepharanthin (10μ M) and chloroquine (50μ M) enhanced the adriamycin cytotoxicity in the SBC-3/ADM cells. These findings suggest that some membrane-modifying agents could partially overcome the acquired resistance to adriamycin in human small cell lung cancer.
en-copyright=
kn-copyright=

en-aut-name=YamashitaHidetoshi
en-aut-sei=Yamashita
en-aut-mei=Hidetoshi
kn-aut-name=山下英敏
kn-aut-sei=山下
kn-aut-mei=英敏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=human small cell lung cancer cells in culture
kn-keyword=human small cell lung cancer cells in culture
en-keyword=ADM resistant subline
kn-keyword=ADM resistant subline
en-keyword=reversal of resistance
kn-keyword=reversal of resistance
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=1-2
article-no=
start-page=209
end-page=216
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Amplification and expression of myc-related oncogenes n adenovirus-induced tumors
kn-title=アデノウイルス誘発マウス腫瘍における myc 群癌遺伝子の増幅と発現
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Amplification and expression of myc-related oncogenes were studied on adenovirus-induced tumors (D and IC) and spontaneous hapatoma (P), all of which had been successively trans-planted in C3Hf/OK mice. c-myc expression waas elevated in the D, IC anf P tumors, and a 8.9-fold amplification of c-myc was observed in the IC tumor. In the D tumor N-myc expression was elevated and a 1.9-fold amplification of N-myc was also observed. Amplification of c-myc in the IC tumor was suspected to be a result of selection for c-myc amplified cells during successive transplantation. Although expression of genes, c-myc, N-myc and E1A of adenovir-us, suppress each other, the results of this experiment, especially elevated expression of N-myc and c-myc in the D tumor, implicated deregulation of myc family genes in malignancies indiced by adenovirus.
en-copyright=
kn-copyright=

en-aut-name=OkinoTakeshi
en-aut-sei=Okino
en-aut-mei=Takeshi
kn-aut-name=沖野毅
kn-aut-sei=沖野
kn-aut-mei=毅
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=香川医科大学病理学講座第一病理学
en-keyword=アデノウイルス
kn-keyword=アデノウイルス
en-keyword=癌遺伝子
kn-keyword=癌遺伝子
en-keyword=c-myc
kn-keyword=c-myc
en-keyword=N-myc
kn-keyword=N-myc
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=1-2
article-no=
start-page=153
end-page=164
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Changes in dopamine D-1 and D-2 receptors in the rat striatum after long term treatment with haloperidol-Comparison among intermittent, continuous and very long term treatment
kn-title=ハロペリドール長期投与後のラット線条体 D-1・D-2 受容体の変化―間欠投与・持続投与・超長期時持続投与の比較―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of long-term treatment with haloperidol (2mg/kg/day) on dopamine receptors in the rat striatum was examined using in vitro quantitative autoradiography. Rats treated with haloperidol showed an increase in striatal D-2 receptor binding as revealed by [(3)H] spiperone. Striatal D-1 receptos labeled with [(3)H] SCH 23390 were not changed following treatment with haloperidol in young rats for 2 weeks, while, it was decreased following 85 weeks of tretment. The striatal D-1 receptors were decreased also after a 4 week treatment with haloperidot in aged rats. These results suggest that haloperidol treatment in the aged rats results in D-2 receptor supersensitivity and a decline in D-1 receptors. Such relative supersensitivity of the D-2 receptor over the D-1 receptor may be related to the vulnerability to tardive dyskinesia of the aged.
en-copyright=
kn-copyright=

en-aut-name=NishikawaHiroshi
en-aut-sei=Nishikawa
en-aut-mei=Hiroshi
kn-aut-name=西川浩
kn-aut-sei=西川
kn-aut-mei=浩
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=dopamine receptors
kn-keyword=dopamine receptors
en-keyword=haloperidol
kn-keyword=haloperidol
en-keyword=aging
kn-keyword=aging
en-keyword=striatum
kn-keyword=striatum
en-keyword=tardive dyskinesia
kn-keyword=tardive dyskinesia
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=5-6
article-no=
start-page=505
end-page=515
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Zinc metabolism in the endotoxin-treated rats
kn-title=エンドトキシンが体内亜鉛代謝に及ぼす影響に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effect of endotoxin administration on zinc metabolism was studied in rats. In the endotoxin-treated rats, serum zinc concentration was significantly reduced as compared to saline-treated rats (control group). On the other hand, hepatic zinc concentration was significantly increased after endotoxin administration as compared to the control group. However, the zinc concentrations of the liver cell components showed slightly dissimilarity. In the mitochondria and cytsol, the concentration increased significantly after endotoxin administration as compared to the control group, whereas no change was observed in the microsomes. Furthermore, we have examined whether the increase of the zinc level in the cytosol of the liver is associated with zinc-binding protein metallothioneins (MTs) or not. MTs also increased significantly after endotoxin administration. Furthermore hepatic MTs were analyzed for MT isoforms. In the endotoxin-treated MT-II was the major Iso-MT. Judging from these results and some other published reports, the role of zinc metabolism in endotoxemia is proposed to be as follows. In endotoxemia the serum zinc concentration is reduced and as a result the production of superoxide by polymorphonuclear leukocytes is increased as zinc has an inhibitory effect on it. This free radical helps the host against the organism. On the other hand zinc accumulation in the liver following endotoxin administration increases the activity of the zinc binding-enzyme and also stabilizes the plasma membrane. MTs induced by endotoxin protect the host from the harmful effects of the free radical in the host by its scavenging action.
en-copyright=
kn-copyright=

en-aut-name=MatsumiMasaki
en-aut-sei=Matsumi
en-aut-mei=Masaki
kn-aut-name=松三昌樹
kn-aut-sei=松三
kn-aut-mei=昌樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=エンドトキシン
kn-keyword=エンドトキシン
en-keyword=亜鉛
kn-keyword=亜鉛
en-keyword=メタロチオネイン
kn-keyword=メタロチオネイン
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=701
end-page=711
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the pathogenesis of interstitial pneumonia of collagen vascular diseases Part 2. Examination of interleukin 2 receptor in interstitial pneumonia of collagen vascular diseases
kn-title=膠原病肺の病態に関する研究　第2編　膠原病肺における血清中および気管支肺胞洗浄液中 soluble IL-2 receptor の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Abnormality of cellular immunity has been reported in the pathogenesis of collagen vascular diseases (CVD). IL-2 and IL-2 receptors play important roles as immunological regulation in CVD. In this study, the soluble forms of IL-2 receptor (sIL-2R) and IL-2 receptor positive lymphocytes (CD25) were analyzed to evaluate the role of IL-2R in the pathogenesis of interstitial pneumonia (IP) of CVD such as RA, SLE, polymyositis/dermatomyositis (PM/DM), and PSS and idiopathic interstitial pneumonia (IIP) as a disease control. High levels of sIL-2R were found in sera of patients with IP of CVD. The level of soluble IL-2R in sera of RA without IP correlated with the disease activity of the joints, while the level of sIL-2R in sera of RA with IP was higher than in that of RA without IP. Soluble IL-2R in bronchoalveolar lavage fluind (BALF) was also measured and the level was higher in IP with CVD. There were fewer IL-2R positive lymphocytes in the peripheral blood of CVD with IP than in the normal controls or IIP cases, although the serum level of sIL-2R was higher in CVD with IP and IIP than in the normal controls. These findings indicate that actibve immunological activities involving IL-2/IL-2R/sIL-2R systems play an important role in the pathogenesis of IP of CVD.
en-copyright=
kn-copyright=

en-aut-name=YokotaSatoshi
en-aut-sei=Yokota
en-aut-mei=Satoshi
kn-aut-name=横田聡
kn-aut-sei=横田
kn-aut-mei=聡
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=collagen vascular disease
kn-keyword=collagen vascular disease
en-keyword=interstitial pneumonia
kn-keyword=interstitial pneumonia
en-keyword=bronchoalveolar lavage
kn-keyword=bronchoalveolar lavage
en-keyword=soluble IL-2 receptor
kn-keyword=soluble IL-2 receptor
en-keyword=IL-2 receptor positive lymphocyte
kn-keyword=IL-2 receptor positive lymphocyte
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=4
article-no=
start-page=281
end-page=292
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Pharmacological specificity of antipsychotic, antiischemic and some other drugs for σ receptors labeled with [(3)H] haloperidol
kn-title=ラット脳内 σ 受容体の薬理学的特異性に関する研究―とくに抗精神病薬との抗虚血剤の作用について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Pharmacological specificity of several classes of drugs such as antipsychotics and antiischemic agents was assessed for σ receptors labeled with [(3)H] haloperidol. Specific binding of [(3)H] haloperidol in the presence of 25 nM spiperone was saturable and high affinity )Kd=1.96±1.31 nM, Bmax=2.37±0.27pmol/mg of protein;n=8). Among the 29 antipsychotics tested in inhibition studies, bromperidol and haloperidol were the most potent inhibitors (Ki=0.9nM, 1.0nM, respectively). The conventional antipsychotics moperone, timiperone etc. and the novel promising drugs YM-09151, Y-516, BMY-14802 and remoxipride potently inhibited [(3)H] haloperidol binding with the Ki in the range of low to moderate nanomolar. On the other hand, among the other 27 drugs tested, the antispasmodics eperisone and tolperisone, the antiischemic agents ifenprodil, the Ca(2+) antagonist flunarizine and cinnarizine, and the antitussives carbetapentane, cloperastine and dextromethorphan, were especially potent inhibitors. These results, taken together with the evidence that the antiischemic agents ifenprodil and dextromethorphan antagozine NMDA responses and NMDA receptor complex is a possible site of action for neuroprotective agents, strongly suggest that σ receptors may be potential sites of action for antiischemic as well as antipsychotic drugs, i.e., σ receptors mediate the neuroprotective effects of certain antiischemic agents by affecting the NMDA receptor complex.
en-copyright=
kn-copyright=

en-aut-name=ZushiYoshifumi
en-aut-sei=Zushi
en-aut-mei=Yoshifumi
kn-aut-name=図子義文
kn-aut-sei=図子
kn-aut-mei=義文
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=sigma receptors
kn-keyword=sigma receptors
en-keyword=antipsychotics
kn-keyword=antipsychotics
en-keyword=ifenprodil
kn-keyword=ifenprodil
en-keyword=dextromethorophan
kn-keyword=dextromethorophan
en-keyword=eperisone
kn-keyword=eperisone
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=625
end-page=637
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Metallothionein gene expression in rat liver following intraperitonal endotoxin administration
kn-title=エンドトキシン投与ラットにおける肝内メタロチオネイン遺伝子発現に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the functions of hepatic metallothioneins (MTs) after the administration of endotoxin (lipopolysaccharide : LPS), we investigated the expression on MT genes in the bacterial endoxin-treated rat liver by Norhern blot hybridization and in situ hybridization methol with riboprobes synthesized from mouse cDNA of MT-Ⅱ chronologically. Northern blot analysis revealed a rapid increase in the amount of MT gene transcripts in the liver 3 hours after the administration of LPS, with a maximum at 6 to 12 hours followed by a gradual decrease. In the in situ hybridization method, MT genes are expressed in the liver lobule for 3 hours after the adiminstration of LPS, and hepatocellular damage was observed at 6 hours after the LPS administration initially and expanded most extensively at 18 hours. During this peripd, MT genes are expressed in intact tissue intensely and specifically. At 24 hours after the administration, transcripts of the MT gene were detected in intact hepatocytes around the shrinking necrotic area. These findings suggest that MTs protect the liver cells by scavenging the free radicals, which probably cause liver cell damage due to LPS administration, and that MTs provide the zinc ions necessary for stabilizing the cell membrane and to heal the liver cell damge.
en-copyright=
kn-copyright=

en-aut-name=TagaNaoyuki
en-aut-sei=Taga
en-aut-mei=Naoyuki
kn-aut-name=多賀直行
kn-aut-sei=多賀
kn-aut-mei=直行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=エンドトキンショック
kn-keyword=エンドトキンショック
en-keyword=メタロチオネイン
kn-keyword=メタロチオネイン
en-keyword=in situ hybridization
kn-keyword=in situ hybridization
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=1-2
article-no=
start-page=183
end-page=197
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on pathogenesis and treatment of cerebral vasospasm Part 2. Effects of PGI2 analogue, thromboxane A2 synthetase inhibitor and Ca blocker on experimental delayed spasm models
kn-title=脳血管攣縮の発生機序と治療に関する実験的研究 第2編 実験的遅発性脳血管攣縮に対する PGI2 analogue, Thromboxane A2 合成酵素阻害剤, Ca 拮抗剤の効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of a PGI2 analogue (OP-41483), a thromboxane A2 synthetase inhibitor (OKY-046) and a Ca blocker (nifedipine) on the diameter of constricted basilar arteries and on the regional cerebral blood flow (r-CBF) in the brain stem were investigated in the cat delayed spasm model. The experiment was performed three days (72 hours) after artificial subarachnoid hemorrhage. The basilar artery was exposed transclivally, and more advanced vasospasm was produced by topical application of a lysed erythrocyte solution for 5 to 6 hours which domonstrated no more vascular dilatation even by topical application of papaverine hydrochloride (0.01mg/ml). In the delayed spasm model, the intravenous administration of neither OP-41483 (8μg/kg), OKY-046 (60mg/kg) nor nifedipine (0.003mg/kg) affected the vascular diameter. OP-41483 increased r-CBF in the brain stem in 3, and nifedipine increased it in 4 out of the 5 studied delayed spasm models, whereas OKY-046 never increased r-CBF (n=5). There was no significant difference in the amount of fatty acids including arachidonic acid between normal and constricted arteries. This study suggested that thromboxane A2 is not the major factor of cerebral vasospasm and OKY-046 might not be effective on vascular diameter or r-CBF at the late spasm stage. However, the PGI2 analogue (OP-41483) and Ca blocker (nifedipine) may be effective in increasing r-CBF even at the late spasm stage.
en-copyright=
kn-copyright=

en-aut-name=MotokiMototsugu
en-aut-sei=Motoki
en-aut-mei=Mototsugu
kn-aut-name=元木基嗣
kn-aut-sei=元木
kn-aut-mei=基嗣
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科教室
en-keyword=cerebral vasospasm
kn-keyword=cerebral vasospasm
en-keyword=thromboxane A2
kn-keyword=thromboxane A2
en-keyword=OP-41483
kn-keyword=OP-41483
en-keyword=OKY-046
kn-keyword=OKY-046
en-keyword=nifedipine
kn-keyword=nifedipine
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=1-2
article-no=
start-page=161
end-page=171
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The accumulation of metallothionein in the rat kidney injured by temporal ischemia
kn-title=虚血性腎傷害による亜鉛代謝と腎内メタロチオネインの変動に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The renal and hepatic metallothionein (MT) and serum zinc levels were studied in rats following renal ischemia, to clarify the effects of renal damage on the zinc metabolism. The serum zinc concentration began to decrease on the 4th day in the bilateral renal ischemic rat. The accumulation of hepatic MT was stimulated by sham operation and was augmented furthermore by renal ischemic damage. The renal MT level increased gradually and reached the maximum on the 3rd day in the bilateral renal ischemic rat. The MT level in the injured kidney was higher than that in the intact kidney in the unilateral renal ischemic rat. These results suggested that the mechanism of MT synthesis in the kidney was different from that in the liver, and that some local factor might induce MT in the injured kidney.
en-copyright=
kn-copyright=

en-aut-name=MizukawaShun-ichi
en-aut-sei=Mizukawa
en-aut-mei=Shun-ichi
kn-aut-name=水川俊一
kn-aut-sei=水川
kn-aut-mei=俊一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=亜鉛
kn-keyword=亜鉛
en-keyword=虚血性急性腎不全
kn-keyword=虚血性急性腎不全
en-keyword=メタロチオネイン
kn-keyword=メタロチオネイン
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=1-2
article-no=
start-page=147
end-page=159
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Neurophysiological study of deep brain stimulation for the treatment of deafferentation pain Part 2. Usefulness of deep cerebral sensory evoked potentials (SEP) for assessment of traget points in the lemniscal system
kn-title=Deafferentation pain に対する脳深部刺激療法の研究 第2編― 内側毛帯系刺激における除痛点の脳深部知覚誘発反応（SEP）による評価について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To relieve deafferentation pain, electrophysiological assessment of target points was performed using deep cerebral SEPs. As a preliminary experiment, the relationship between the waveform of the SEP and the anatomical structure of the brain was examined in cats. The infraorbital nerve was stimulated and the SEP was recorede around the VPM. From the rostral edge of the medial leminiscus (ML), a high voltage positive wave was recorded, and from the ventral side of the VPM a wide negative wave with positive wavelets was recorded. For the treatment of three cases of thalamic pain, the deep cerebral SEP was recorded during the insertion of a chronic electrode for deep brain stimulation. By contralateral median nerve stimulation, the high voltage posotive waves (peak latency ; 13-15msec) from the ML and the subsequent unerven waves from the VPL were recorded along the trajectory. The later uneven waves were composed of wide negative waves and positive wavelets, which were thought to be derived from the synaptic activity of the VPL and thalamocortical rediation, respectively. Effective pain  relief was obtained at the border zone of the ventral VPL and the ML, where the characteristic waves of the VPL changed to those of the ML. The deep cerebral SEP can be used for the identification of target points electrophysiologically.
en-copyright=
kn-copyright=

en-aut-name=TomitaSusumu
en-aut-sei=Tomita
en-aut-mei=Susumu
kn-aut-name=富田享
kn-aut-sei=富田
kn-aut-mei=享
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科学教室
en-keyword=deafferentation pain
kn-keyword=deafferentation pain
en-keyword=deep brain stimulation
kn-keyword=deep brain stimulation
en-keyword=sensory evoked potential
kn-keyword=sensory evoked potential
en-keyword=leminiscus medialis
kn-keyword=leminiscus medialis
en-keyword=nucleus ventrocaudalis
kn-keyword=nucleus ventrocaudalis
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=1-2
article-no=
start-page=117
end-page=127
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Metallothionein gene expression in rat brain following intraperitoneal endotoxin administration
kn-title=エンドトキシンによるラット脳内メタロチオネイン遺伝子発現に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the acute-phase response in brain, we investigated the induction of metallothionein (MT) genes by administering an endotoxin (lipopolysaccharide) in rat intraperitoneum. We performed in situ hybridization on the serial brain sections to identify the cells expressing the MT genes in the acute-phase. After endotoxin administration, transcripts of MT genes were detected in the arachnoideal, ependymal cells and the Bergmann glia of the cerebellum, while no significant induction of the MT genes by zinc ion was observed in the brain. These results suggest that the acute-phase response occurs specifically in at least these three non-neuronal cells.
en-copyright=
kn-copyright=

en-aut-name=ItanoYoshitaro
en-aut-sei=Itano
en-aut-mei=Yoshitaro
kn-aut-name=板野義太郎
kn-aut-sei=板野
kn-aut-mei=義太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=メタロチオネイン
kn-keyword=メタロチオネイン
en-keyword=エンドトキシン
kn-keyword=エンドトキシン
en-keyword=脳
kn-keyword=脳
en-keyword=acute-phase
kn-keyword=acute-phase
en-keyword=in situ hybridization
kn-keyword=in situ hybridization
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=489
end-page=499
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The usefulness of transvaginal ultrasonography and MRI in endometrial carcinama : Evaluating myomertrial and cervical invasion
kn-title=子宮体癌に対する経腟走査超音波断層法とMRIの有用性について―筋層浸潤と頚部浸潤の評価―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Between October, 1988 and March, 1991, twenty-mine patients with endometrial carcinoma bad both transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) performed following hysterectomy at the Departmetn of Gynecology and Obstetrics, Okayama University Medical School. The findings were compared with the pathological findings to determine the usefulness of each method. The sensitivity of dectecthing myometrial invasion was 100% by TVUS and 96% by MRI. The accuracy was 86% by each method. The depth of myometrial invasion was classified into 3 degrees [no myometrial invasion, superficial invasion (≤1/2), deep invasion (>1/2)]. The correct diagnostic rate was 86% by TVUS and MRI. The minimum width and the minimum/maximum width ratio of the intact myometrium obtained by each method in the pathological deep invasion group were significantly lower than those obtained in the other two groups (p<0.01). The sensitivity, the accuracy and the specificity of detecting cervical invasion were 89%, 93% and 95% by both methods. There was no difference between TVUS and MRI for diagnosing myometrial and cerical invasion of endometrial carcinoma.
en-copyright=
kn-copyright=

en-aut-name=YoshiharaEisuke
en-aut-sei=Yoshihara
en-aut-mei=Eisuke
kn-aut-name=吉原英介
kn-aut-sei=吉原
kn-aut-mei=英介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部産科婦人科学教室
en-keyword=子宮体癌
kn-keyword=子宮体癌
en-keyword=経腟走査超音波断層法
kn-keyword=経腟走査超音波断層法
en-keyword=MRI
kn-keyword=MRI
en-keyword=筋層浸潤
kn-keyword=筋層浸潤
en-keyword=頚部浸潤
kn-keyword=頚部浸潤
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=7-8
article-no=
start-page=1013
end-page=1018
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Lymph node metastases of right colon cancer
kn-title=右側結腸癌に対するリンパ節郭清範囲の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The lymph node metastases of the right side colon were studied. Among 58 cases of right side colon, nodal involvements were found in 53.4%. Metastases to the epicolic and paracolic nodes were confined to an area within 10 cm from the tumor margin. Metastases to the intermediate nodes were found in 20.7% and metastases to the main nodes in 15.5%. Jumping metastases were recognized in 5 out of 31 cases of nodal involvement (16.1%). As the rate of jumping metastases is unexpectedly high, lymph node dissection for right colon cancer should be done as far as the main nodes.
en-copyright=
kn-copyright=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=1
ORCID=

en-aut-name=HizutaAkio
en-aut-sei=Hizuta
en-aut-mei=Akio
kn-aut-name=日伝晶夫
kn-aut-sei=日伝
kn-aut-mei=晶夫
aut-affil-num=2
ORCID=

en-aut-name=HamadaFumihiro
en-aut-sei=Hamada
en-aut-mei=Fumihiro
kn-aut-name=浜田史洋
kn-aut-sei=浜田
kn-aut-mei=史洋
aut-affil-num=3
ORCID=

en-aut-name=ShiikiShigeo
en-aut-sei=Shiiki
en-aut-mei=Shigeo
kn-aut-name=椎木滋雄
kn-aut-sei=椎木
kn-aut-mei=滋雄
aut-affil-num=4
ORCID=

en-aut-name=MatsubaraNagahide
en-aut-sei=Matsubara
en-aut-mei=Nagahide
kn-aut-name=松原長秀
kn-aut-sei=松原
kn-aut-mei=長秀
aut-affil-num=5
ORCID=

en-aut-name=AkazaiYoshihiro
en-aut-sei=Akazai
en-aut-mei=Yoshihiro
kn-aut-name=赤在義浩
kn-aut-sei=赤在
kn-aut-mei=義浩
aut-affil-num=6
ORCID=

en-aut-name=SuzakiKiichi
en-aut-sei=Suzaki
en-aut-mei=Kiichi
kn-aut-name=須崎紀一
kn-aut-sei=須崎
kn-aut-mei=紀一
aut-affil-num=7
ORCID=

en-aut-name=WatanabeTetsuya
en-aut-sei=Watanabe
en-aut-mei=Tetsuya
kn-aut-name=渡辺哲也
kn-aut-sei=渡辺
kn-aut-mei=哲也
aut-affil-num=8
ORCID=

en-aut-name=NonakaYasuyuki
en-aut-sei=Nonaka
en-aut-mei=Yasuyuki
kn-aut-name=野中泰幸
kn-aut-sei=野中
kn-aut-mei=泰幸
aut-affil-num=9
ORCID=

en-aut-name=KimuraToshikazu
en-aut-sei=Kimura
en-aut-mei=Toshikazu
kn-aut-name=木村臣一
kn-aut-sei=木村
kn-aut-mei=臣一
aut-affil-num=10
ORCID=

en-aut-name=FuchimotoSadanori
en-aut-sei=Fuchimoto
en-aut-mei=Sadanori
kn-aut-name=淵本定儀
kn-aut-sei=淵本
kn-aut-mei=定儀
aut-affil-num=11
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=11
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=12
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=右側結腸癌
kn-keyword=右側結腸癌
en-keyword=リンパ節転移率
kn-keyword=リンパ節転移率
en-keyword=跳躍転移
kn-keyword=跳躍転移
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=457
end-page=469
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Metallothionein induction in the rat kidneys by endotoxin and zinc administration
kn-title=エンドトキシンおよび亜鉛投与ラットにおける腎メタロチオネインの誘導に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Metallothionein (MT) induction in the rat kidneys by endotoxin and zinc was investigated at the MT-protein level and the MT-mRNA level. The MT-mRNA level increased 3-6 hr after endotoxin administration, which suggested that MT was not transported from an other organ, but was de novo synthesized. Two MT-protein isoforms, MT-Ⅰ and MT-Ⅱ, were induced by administration of both endotoxin and zinc. The maximum levels of the proteins were seen 9 hr after administration of endotoxin and zinc. The span life of the renal MT induced by zinc was shorter than that of the liver MT induced by zinc. The MT-Ⅱ isoform was predominantly induced by both inducers, endotoxin and zinc, and the ratios of MT-Ⅱ to MT-Ⅰ were relatively constant. The finding that MT-Ⅰ and MT-Ⅱ were almost equally induced by zinc in the liver indicate that MT induction is controlled by an organ-specific system.
en-copyright=
kn-copyright=

en-aut-name=KanaiYoshizumi
en-aut-sei=Kanai
en-aut-mei=Yoshizumi
kn-aut-name=金居義純
kn-aut-sei=金居
kn-aut-mei=義純
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=エンドトキシン
kn-keyword=エンドトキシン
en-keyword=亜鉛
kn-keyword=亜鉛
en-keyword=腎メタロチオネイン
kn-keyword=腎メタロチオネイン
en-keyword=高速液体クロマトグラフィー
kn-keyword=高速液体クロマトグラフィー
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=3-4
article-no=
start-page=413
end-page=423
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studis on the pathogenesis of idiopathic interstitial pneumonia Part 1. Analysis of local cellular response in lungs by bronchoalveolar lavage of patients with idiopathic interstitial pneumonia
kn-title=特発性間質性肺炎の病態に関する研究　第2編　特発性間質性肺炎の気管支肺胞洗浄法による検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The cellular components in lungs of idiopathic interstitial pneumonia (IIP) and interstitial pneumonia with collagen disease (IP with CD) were examined by bronchoalveolar lavage (BAL) to analyze the pathogenesis of IIP. The findings of BAL fluid of IIP and IP with CD were increase of total cell count and increased percent of lymphocytes, neutrophils, eosinophils and basophil/mast cells in comparison with the normal control. The BAL fluid of the patients with IIP and IP with CD in active stage contained a higher proportion of lymphocyte, neutrophil, eosinophil and basophil/mast cell than those in a nonactive stage. Furthermore, an increase of T-cells and Ia positive T-cells was detected in the examination of lymphocyte subpopulation in BAL fluid of patients with IIP, while the lymphocyte subpopulation of peripheral blood showed no significant difference. Cellular components in BAL fluid of IIP patients treated with or without steroids were compared. Under steroid therapy a decrease of total cell count and eosinophil was shown in BAL fluids of patients with IIP. These findings indicate that various cells such as macrophage, lymphocyte, neutrophil eosinophil and basophil/mast cell in lungs play important roles in the pathogenesis of IIP and IP with CD.
en-copyright=
kn-copyright=

en-aut-name=FujitaMichio
en-aut-sei=Fujita
en-aut-mei=Michio
kn-aut-name=藤田道雄
kn-aut-sei=藤田
kn-aut-mei=道雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Idiopathic interstitial pneumonia
kn-keyword=Idiopathic interstitial pneumonia
en-keyword=Bronchoalveolar lavage
kn-keyword=Bronchoalveolar lavage
en-keyword=Lymphocyte subpopulation
kn-keyword=Lymphocyte subpopulation
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=3-4
article-no=
start-page=247
end-page=258
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental and clinical studies on interferon and its inducers Part 1. Effects of interferon and its inducers on neutrophil chemiluminescence
kn-title=インターフェロン並びにインターフェロン誘発剤に関する基礎的・臨床的研究　第1編　インターフェロン並びにインターフェロン誘発剤の好中球 Chemiluminescence に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To evaluate one the effects of interferon (IFN) and its inducers on neutrophil functions neutrophil chemiluminescence (ChL) was assayed on 31 healthy individuals, nine patients treated with IFN-α (human lymphoblastoid interferon, 3×10(6)units/day i. m. daily) and 11 patients treated with Ge-132 (2,250mg/day p. o. daily). The base lines (BLs), peak levels (PLs) and times to PLs (PLs) of neutrophil ChL were examined before, one week and one month after the treatment. The direct effects of IFN-α, Ge-132 and OK-432 on neutrophil ChL were also evaluated by using an in vitro experimental system. PLs were significantly increased one week after the treatment with IFN-α or Ge-132. However, they were decreased to the pretreatment level one month after the treatment. In vitro experimental system IFN-α enhanced PLs of neutrophil ChL showing dose and time dependencies. On the other hand Ge-132 and OK-432 showed no direct effect on neutrophil ChL in vitro. These findings suggest that IFN-α and Ge-132 enhance the host defense mechanism by the activation of neutrophil functions, and also suggest that they have some benefits not only in the clinical management of cancer but also of chronic infection.
en-copyright=
kn-copyright=

en-aut-name=FukumotoMitsuhiro
en-aut-sei=Fukumoto
en-aut-mei=Mitsuhiro
kn-aut-name=福本光宏
kn-aut-sei=福本
kn-aut-mei=光宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Interferon
kn-keyword=Interferon
en-keyword=Ge-132
kn-keyword=Ge-132
en-keyword=Ok-143
kn-keyword=Ok-143
en-keyword=Neutrophil Chemiluminescence
kn-keyword=Neutrophil Chemiluminescence
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=7-8
article-no=
start-page=927
end-page=943
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Neuropathological study on neuronal swelling degeneration in the substantia nigra of Olivo-Ponto-Cerebellar Atrophy (OPCA)
kn-title=Olivo-Ponto-Cerebellar Atrophy (OPCA) の中脳黒質ニューロンの腫脹性病変について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In 6 out of 7 autopsy cases of olivopontocerebellar atrophy, we found characteristic features of neuronal swelling degeneration (abbr. NSD) in the nerve cell of the substantia nigra. NSD was classified into 4 types according to the microscopic features. The cell body of the type A NSD is much larger than the usual nerve cell, contains melanin granules, is round in shape and appears granular. This cell sometimes contains a shrunken nucleus, Marinesco body, Nissl granules and rest of melanin pigment, suggesting its origin in the degenerating melanin containing nerve cell. In type B NSD the periphery of the swollen cell body appears to be frosted glass with a Nissl Substance. A part of the type B NSD was suggested to have its origin in the nerve cell which has no melanin pigment. Type C NSD is round or irregular in shape and appears to be vacuolar, suggesting its origin in the dendritic process. Type D NSD is sharply bounded from the surrounding tissue and amorphous structures. Judging from its staining characteristics, its origin was suggested to be in the axon. The significance and pathogenesis of the NSD are discussed with special reference to its relation to glutamic acid.
en-copyright=
kn-copyright=

en-aut-name=NambaMasuyuki
en-aut-sei=Namba
en-aut-mei=Masuyuki
kn-aut-name=難波益之
kn-aut-sei=難波
kn-aut-mei=益之
aut-affil-num=1
ORCID=

en-aut-name=TanakaTakaho
en-aut-sei=Tanaka
en-aut-mei=Takaho
kn-aut-name=田中隆穂
kn-aut-sei=田中
kn-aut-mei=隆穂
aut-affil-num=2
ORCID=

en-aut-name=IshinoHirosi
en-aut-sei=Ishino
en-aut-mei=Hirosi
kn-aut-name=石野博志
kn-aut-sei=石野
kn-aut-mei=博志
aut-affil-num=3
ORCID=

en-aut-name=SenoHaruo
en-aut-sei=Seno
en-aut-mei=Haruo
kn-aut-name=妹尾晴夫
kn-aut-sei=妹尾
kn-aut-mei=晴夫
aut-affil-num=4
ORCID=

en-aut-name=IshizuHideki
en-aut-sei=Ishizu
en-aut-mei=Hideki
kn-aut-name=石津秀樹
kn-aut-sei=石津
kn-aut-mei=秀樹
aut-affil-num=5
ORCID=

en-aut-name=KurodaSigetosi
en-aut-sei=Kuroda
en-aut-mei=Sigetosi
kn-aut-name=黒田重利
kn-aut-sei=黒田
kn-aut-mei=重利
aut-affil-num=6
ORCID=

en-aut-name=KuyamaKeisuke
en-aut-sei=Kuyama
en-aut-mei=Keisuke
kn-aut-name=久山圭介
kn-aut-sei=久山
kn-aut-mei=圭介
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=慈圭精神医学研究所

affil-num=2
en-affil=
kn-affil=西宇部病院

affil-num=3
en-affil=
kn-affil=島根医科大学神経精神医学教室

affil-num=4
en-affil=
kn-affil=島根医科大学神経精神医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=OPCA
kn-keyword=OPCA
en-keyword=Substantia nigra
kn-keyword=Substantia nigra
en-keyword=neuronal swelling degeneration
kn-keyword=neuronal swelling degeneration
en-keyword=glutamate
kn-keyword=glutamate
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=11-12
article-no=
start-page=1173
end-page=1187
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Long-lasting effects of ceruletide on L-Dopa-induced dyskinesias in monkey
kn-title=サルの L-Dopa-induced dyskinesia に対する Ceruletide の長期効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The long-lasting effects of ceruletide(CLT), a cholecystokinin-8(CCK-8) analogue, on involuntary movements were investigated. Nine monkeys were used. One group(6 monkeys) received unilateral lesions to the ventromedial tegmentum(VMT) of the midbrain. The second group(3 monkeys) served as controls. Hypokinesia was produced after lesioning of the VMT. Administration of a large amount of L-Dopa or direct intracaudate injection of dopamine(DA) relieved the symptoms initially but then induced dyskinesias later. Two monkeys with reproducible dyskinesias were chosen for further study. Systemically administered CLT combined with L-Dopa improved the hypokinesia without inducing dyskinesia. These effects of a single dose of 50 μg/kg CLT continued up to 9 days. Direct combined administration of CLT and DA into the dorsomedial part of the head of the caudate nucleus ipsilateral to the VMT lesion improved the hypokinesia without inducing dyskinesia. The effect of a single direct injection of 20 ng/kg CLT persisted for 3 days. The long-lasting effects of systemically and directly administered CLT were confirmed. These findings suggest that CLT modulates the DA system indirectly through the central CCK system, especially in the dorsomedial part of the head of the caudate nucleus.
en-copyright=
kn-copyright=

en-aut-name=MizobuchiMasayuki
en-aut-sei=Mizobuchi
en-aut-mei=Masayuki
kn-aut-name=溝渕雅之
kn-aut-sei=溝渕
kn-aut-mei=雅之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科学教室
en-keyword=Ceruletide
kn-keyword=Ceruletide
en-keyword=L-Dopa-induced dyskinesia
kn-keyword=L-Dopa-induced dyskinesia
en-keyword=Cholecystokinin
kn-keyword=Cholecystokinin
en-keyword=Peptide regulation
kn-keyword=Peptide regulation
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=11-12
article-no=
start-page=1069
end-page=1078
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on platelet function in bronchial asthma Part 1. Morphological change and serotonin-releasability of platelets in bronchial asthmatics
kn-title=気管支喘息の血小板機能に関する研究 第1編 喘息患者血小板の形態変化とセロトニン遊離能の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To calrify the role of platelets at the site of allergic reaction, ultrastructural observation, measurement of plasma serotonin levels and serotonin-releasability of platelets after various stimuli were studied in 29 asthmatics and 6 normal controls. The results were as follows : 1) Plasma serotonin levels were higher during the attack stage than non-attack stage in asthmatics. 2) Morphological changes and the aggregation of platelets were observed by scanning electron microscopy after stimulation with platelet activating factor(PAF), CaI, anti-IgE and anti-IgG. 3)The serotonin-releasability of platelets stimulated by CaI was significantly decreased in severe asthmatics, compared with mild asthmatics and normal subjects(p<0.05). However, there were no significant differences between steroid dependent and non-steroid dependent intractable asthmatics in severe asthma. 4) The releasability of serotonin was decreased in most cases during asthmatic attack and was suppressed by aminophyllin. 5) The serotonin-releasability of platelets stimulated by anti-IgG of Candida antigen was remarkably enhanced aftre incubation with serum, although releasability was not increased with heart-treated serum. These results suggest that platelets play an important role in bronchoconstriction induced by various immunological reactions involved with complement activation in the pathogenesis of bronchial asthma.
en-copyright=
kn-copyright=

en-aut-name=SunamiKoji
en-aut-sei=Sunami
en-aut-mei=Koji
kn-aut-name=角南宏二
kn-aut-sei=角南
kn-aut-mei=宏二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=platelet
kn-keyword=platelet
en-keyword=serotonin
kn-keyword=serotonin
en-keyword=bronchial asthma
kn-keyword=bronchial asthma
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=7-8
article-no=
start-page=841
end-page=857
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on the hepatic effects of sevoflurane anesthesia
kn-title=セボフルレン麻酔の肝に及ぼす影響に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The hepatic effects of sevoflurane administered under different inspiratory oxygen concentrations were examined. Male rats pretreated with phenobarbital for 5 days and fasted for 24 hours were anesthetized with 2.4% sevoflurane administered under different oxygen concentrations (10%, 14%, 21% or 100%). The rats administered sevoflurane under 21% oxygen were used as the control. The amount of microsomal protein, the content and activity of hepatic microsomal enzymes, and the amount of enzymes released from the liver cells (GPT, OCT) of each group of rats were measured for 7 days after these procedures. The content of cytochrome P-450 and the activity of aminopyrine demethylation and aniline dehydration were decreased significantly to about 58%, 43% and 40% that of the control, respectively. Furthermore the plasma level of GPT and OCT was elevated to 1,107±620 IU/L and 422±270 IU/L respectively soon after sevoflurane anesthesia only in the group of rats administered sevoflurane under a 10% oxygen concentration. In this study, severe damage to the liver of the rats was observed after sevoflurane anesthesia under 10% oxygen following enzyme induction and fasting.
en-copyright=
kn-copyright=

en-aut-name=OkadaNaoki
en-aut-sei=Okada
en-aut-mei=Naoki
kn-aut-name=岡田尚起
kn-aut-sei=岡田
kn-aut-mei=尚起
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=セボフルレン麻酔
kn-keyword=セボフルレン麻酔
en-keyword=吸入酸素濃度
kn-keyword=吸入酸素濃度
en-keyword=チトクローム　P-450
kn-keyword=チトクローム　P-450
en-keyword=肝障害
kn-keyword=肝障害
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=97
end-page=106
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Attitude toward mental disorders : A comparative study of a attitude of nurses and attendants between Japan and Brazil
kn-title=精神障害の対する態度―日本, ブラジルの看護婦, 看護士の態度の比較研究―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Attitude of nureses and attendants toward mental disorders was studied by using question-naire in Japan and Brazil. By factor analysis, three factors, negative attitude toward mental disorders and misunder-standing, positive attitude toward mental disorders and mental health ideology were extracted. The score of negative attitude toward mental disorders and misunderstanding was high in Brazil. This was suspected to be caused by poor knowledge about mental disorders. The score of positive attitude toward mental disorders was similar in Japan and Brazil. The score of mental health ideology was high in Japan. Mental health ideology is important to improve the attitude toward mental disorders both Japan and Brazil. It is important to spread knowledge about mental disorders in Brazil. In Japan, it is important to increase the interest in mental disorders.
en-copyright=
kn-copyright=

en-aut-name=TakenamiKatsuko
en-aut-sei=Takenami
en-aut-mei=Katsuko
kn-aut-name=武南克子
kn-aut-sei=武南
kn-aut-mei=克子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=精神障害に対する態度
kn-keyword=精神障害に対する態度
en-keyword=因子分析
kn-keyword=因子分析
en-keyword=精神保健的観念
kn-keyword=精神保健的観念
en-keyword=関心度
kn-keyword=関心度
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=7-8
article-no=
start-page=843
end-page=852
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Analysis of suppressor T cells induced in long-term human allogeneic mixed lymphocyte culture
kn-title=長期リンパ球混合培養で誘導される抑制性T細胞の免疫学的解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Suppressor T cells (Ts) may play an important role in the regulation of immunological responses. Ts may play a role in the long-term acceptance of an allogeneic organ graft and the beneficial effects of donor-specific blood transfusions on subsequent transplant survival. The population of Ts induced in mixed lymphocyte culture (MLC) was analyzed, and the mechanism underlying the suppressor activity was examined. The Ts generated in 10-day MLC were found to belong to the OKT8(+) subset and inhibited both mixed lymphocyte reaction (MLR) and cell-mediated lympholysis. These Ts inhibited MLR in an antigen-specific manner, but failed to alter the kinetics of the MLR. Furthermore, these Ts inhibited the production of endogenous interleukin-2 and exerted a suppressive effect only when added early in the culture. In condition, the precise target of Ts generated in 10-day MLC might be the earliest responding T helper clone.
en-copyright=
kn-copyright=

en-aut-name=TsuboiKatsutoshi
en-aut-sei=Tsuboi
en-aut-mei=Katsutoshi
kn-aut-name=壺井克敏
kn-aut-sei=壺井
kn-aut-mei=克敏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=抑制性T細胞
kn-keyword=抑制性T細胞
en-keyword=リンパ球混合培養
kn-keyword=リンパ球混合培養
en-keyword=mixed lymphocyte reaction
kn-keyword=mixed lymphocyte reaction
en-keyword=cell-mediated lympholysis
kn-keyword=cell-mediated lympholysis
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=7-8
article-no=
start-page=791
end-page=801
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the regulation of eosinophils in bronchial asthma Part 2. Migratory responses of eosinophils from asthmatics
kn-title=気管支喘息における好酸球動態の調節に関する研究　第2編　喘息患者末梢血好酸球の遊走能に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Eosinophil infiltration in lung tissue is one of the characteristic features of bronchial asthma. Such cell infiltration seems to be induced by the eosinophil chemotactic factor (ECF). PAF and IL-5 are potent chemoattractants and activators for eosinophils. To evaluate the reactivity of eosinophils in asthmatics under various conditions, the migratory function of eosinophils to PAF and IL-5 was investigated by the modified Boyden chamber method. Eosinophils of asthmatics were highly purified using a flow cytometric method previously reported. The migratory response of the eosinophils of asthmatics was greater than that of healthy suljects. Eosinophils from atopic asthmatics showed a higher response to PAF than those from non-atopic asthmatics. Eosinophils in the attack stage showed a higher response than those in the non-attack stage. Hypodense eosinophils showed an increased migratory response. The migratory response was correlated to the serum concentration of ECP and blood eosinophil count. These findings suggest that the reactivity of eosinophils is heterogenous and relates to the degree of eosinophilia, and that IL-5 as well as PAF plays an important role in the pathogenesis of bronchial asthma.
en-copyright=
kn-copyright=

en-aut-name=TakahashiHisaho
en-aut-sei=Takahashi
en-aut-mei=Hisaho
kn-aut-name=高橋寿保
kn-aut-sei=高橋
kn-aut-mei=寿保
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Bronchial asthma
kn-keyword=Bronchial asthma
en-keyword=Eosinophil migratory response
kn-keyword=Eosinophil migratory response
en-keyword=Platelet-activating factor
kn-keyword=Platelet-activating factor
en-keyword=Interleukin-5
kn-keyword=Interleukin-5
en-keyword=Eosinophil heterogeneity
kn-keyword=Eosinophil heterogeneity
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=5-6
article-no=
start-page=641
end-page=654
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=1994
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The pathogenesis of interstitial pneumonia and the role of cytokines
kn-title=間質性肺疾患の病態に関する研究―気管支肺胞洗浄液中サイトカインの検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Various cytokines are known to participate in the pathogenesis of interstitial pneumonia follewed by lung fibrosis due to the proliferation of fibroblasts and production of collagen fibers. Patients with interstitial pneumonia including idiopathic interstitial pneumonia (IIP) and interstitial pneumonia with collagen vascular disease (IP with CVD) were examined by bronchoalveolar lavage (BAL). Cytokines such as IL-1α,　TGF-α, and TGF-β in BAL fluid were measured by enzyme linked immunosorbent assay (ELISA). The concentrations of TGF-α and TGF-β in BAL fluid of patients with IIP and IP with CVD were higher than those of normal control, while IL-1α, in BAL fluid was detected in few patoents. The level of TGF-β in BAL fluid was higher in patients with greater decreases in pulmonary function and overt fibrosis on chest X-ray film, although TGF-α was higher in patients with milder disorders. The concentrations of TGF-α and TGF-β showed positive correlation with soluble IL-2 receptor as well as procollagen type Ⅲ in BAL fluid. These results indicated that cytokines regulationg lung fibrosis play important roles in the pathogenesis of interstitial pneumonia.
en-copyright=
kn-copyright=

en-aut-name=SugimotoKeisuke
en-aut-sei=Sugimoto
en-aut-mei=Keisuke
kn-aut-name=杉本啓介
kn-aut-sei=杉本
kn-aut-mei=啓介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=間質性肺疾患
kn-keyword=間質性肺疾患
en-keyword=気管支肺胞洗浄法 (broncho alveolar lavage : BAL)
kn-keyword=気管支肺胞洗浄法 (broncho alveolar lavage : BAL)
en-keyword=Interleukin 1 (IL-1)
kn-keyword=Interleukin 1 (IL-1)
en-keyword=transforming growth factor α
kn-keyword=transforming growth factor α
en-keyword=transforming growth factor β
kn-keyword=transforming growth factor β
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=7-8
article-no=
start-page=747
end-page=761
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Chemical and physiological changes of serum and thoracic-duct lymph in the dog with experimental obstructive jaundice and/or disorder of liver circulation
kn-title=実験的閉塞性黄疸および肝循環障害における血清と胸管リンパ液組成の変動に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A long-term study on the chemical and physiological changes of serum and thoracic-duct lymph in the dog with a ligated common bile duct and/or artificial liver circulation was performed. The influencee of ligation of the common bile duct appeared earlier in the thoracic-duct lymph than in the serum. The portal pressure did not increase in the dog with a ligated common bile duct, but the lymph flow of the thoracic duct was 3 times that before ligation, which would prevent the rapid stagnation of bile pigment in the liver. The portal pressure was not elevated after ligation of the hepatic artery. The cholesterol level in the thoracic-duct lymph was about half of that in the serum. In the dog with ligature of the common bile duct, the serum total cholesterol level was elevated with the elevation of serum bilirubin, whereas that in the lymph of the thoracic duct was not elevated with the elevation of the bilirubin level in the lymph. These findings suggested that cholesterol would not easily enter into the lymphatic route. The serum GPT level increased during the first week after ligation of the hepatic artery, and decreased thereafter. However, after ligation of the common bile duct, the GPT level increased for several weeks after the first week of ligation. The pattern of GPT by both ligations seemed to be cross-crossed. The marked change in the total bilirubin level in the lymph of the thoracic duct suggested its close relation with the lymphatic system. It was proved possible to secure a tube into the thoracic duct for over three weeks by the use of a U-type connector and jacket-type plaster cast.
en-copyright=
kn-copyright=

en-aut-name=UedaYuzo
en-aut-sei=Ueda
en-aut-mei=Yuzo
kn-aut-name=上田祐造
kn-aut-sei=上田
kn-aut-mei=祐造
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=実験的肝障害
kn-keyword=実験的肝障害
en-keyword=閉塞性黄疸
kn-keyword=閉塞性黄疸
en-keyword=肝循環障害
kn-keyword=肝循環障害
en-keyword=胸管リンパ液
kn-keyword=胸管リンパ液
en-keyword=胸管カヌレーション
kn-keyword=胸管カヌレーション
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=7-8
article-no=
start-page=779
end-page=789
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the regulation of eosinophils in bronchial asthma Part 1. Characterization of eosinophil chemotactic factor (ECF) derived from peripheral blood mononuclear cells stimulated with Candida antigen
kn-title=気管支喘息における好酸球動態の調節に関する研究　第1編　喘息患者末梢血単核球由来の好酸球遊走因子（ECF）の解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Eosinophilic infiltration in bronchial tissue is characteristic in the pathogenesis of bronchial asthma. The eosinophil chemotactic factor (ECF) derived from mononuclear cells has been reported to have some effect on the cell infiltration, and interleukin-5 (IL-5), a lymphokine derived from T lymphocytes, to be a factor related to growth, chemotaxis and activation for eosinophils. Lymphocytes accumulated in the bronchoalveolar lavage fluids of non-atopic and severe asthmatics have been shown to be highly responsive to Candida antigen, and high ECF production was observed in non-atopic and severe asthmatics by measurement of ECF activity in the supernatant of peripheral blood mononuclear cells cultured with Candida antigen. In this report, the molecular weight by gel filtration and inhibition test using anti-murine IL-5 antibody were studied to characterize the lymphocyte-derived ECF. Gel filtration analysis of the ECF indicated a molecular weight of 20,000 to 65,000 Da with a peak of activity around 40,000 to 50,000 Da. The ECF activity was reduced by incubation with anti-murine IL-5 antibody, which suggests that the supernatant contains IL-5. ECF from mononuclear cells, containing IL-5, may play an important role in the pathogenesis of eosinophil infiltration in non-atopic and severe asthmatics.
en-copyright=
kn-copyright=

en-aut-name=TakahashiHisaho
en-aut-sei=Takahashi
en-aut-mei=Hisaho
kn-aut-name=高橋寿保
kn-aut-sei=高橋
kn-aut-mei=寿保
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Bronchial asthma
kn-keyword=Bronchial asthma
en-keyword=Candida antigen Eosinophil chemotactic factor
kn-keyword=Candida antigen Eosinophil chemotactic factor
en-keyword=Interleukin-5
kn-keyword=Interleukin-5
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=7-8
article-no=
start-page=769
end-page=778
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Striatal extracellular levels of dopamine and its metabolites during kainate-induced limbic seizures in freely-moving rats measured by brain microdialysis
kn-title=カイニン酸誘発けいれんにおける細胞外ドパミン量の経時的変化―脳内微小透析法を用いた実験的研究―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To investigate the role of brain dopaminergic systems in epilepsy, striatal extracellular levels of dopamins (DA) and its metabolites (3,4-dihydroxyphenylacetic acid : DOPAC and homovanillic acid : HVA) were measured during kainate-induced limbic seizures in freely-moving rats, using brain microdialysis. DA and its metabolites were measured by high performance liquid chromatography. Systemic injection of kainate (10mg/㎏, i. p.), which caused stable limbic seizures, significantly decreased the levels of DA and its metabolites. Intrahippocampal injection of kainae (2.5nmol), which also caused limbic seizures, significantly decreased only the DA levels, while DOPAC and HVA levels were unchanged. Similar to the results of the systemic injectjon, intrastriatal perfusion of kainate (10(-2) or 10(-6) M) significantly decreased the levels of DA, DOPAC and HVA in a dose-dependent manner. These findings indicate that, during kainate-induced limbic seizures, DA release was significantly reduced in the striatum. In conclusion, the hypofunction of striatal dopaminergic systems is related to the initiation and progress in epileptic seizures.
en-copyright=
kn-copyright=

en-aut-name=OhnishiMasaru
en-aut-sei=Ohnishi
en-aut-mei=Masaru
kn-aut-name=大西勝
kn-aut-sei=大西
kn-aut-mei=勝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=kainate
kn-keyword=kainate
en-keyword=brain microdialysis
kn-keyword=brain microdialysis
en-keyword=dopamine
kn-keyword=dopamine
en-keyword=striatum
kn-keyword=striatum
en-keyword=epilepsy
kn-keyword=epilepsy
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=5-6
article-no=
start-page=589
end-page=600
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of human bone marrow stromal cells in the aged Part 1. Influence of aging on composition, growing dynamics and cytokine production in human bone marrow stromal cells
kn-title=骨髄間質細胞の老化に関する研究　第1編　ヒト骨髄間質細胞の細胞構成比率，増殖動態及び造血因子産生能に及ぼす加齢の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bone marrow stromal cells (BMSC) play essential roles in hemopoiesis. In the present study, bone marrow specimens obtained from 23 normal volunteers were cultured with a modified version of Dexter's long term bone marrow culture system to investigate the influences of aging on human BMSC. The composition of BMSC was analyzed by immunofluorescence. The percentage of monocyte/macrophages, adipocytes and T-cells were significantly increased in the aged. BMSC from the aged proliferated more rapidly than those from the young during the first week of culture in the growing dynamics study. Cytokine concentration in the conditioned medium was also measured in terms of BMSC function by radioimmunoasssay or enzyme-linked immunosorbent assay. The concentration of macrophage colony stimulating factor (M-CSF) on day 21 increased in the culture from the young, while interleukin-6(IL-6) concentration was higher on day 7 in the culture from the aged. These findings show no evidnece of BMSC defects in the aged. They show evidnece suggesting advanced function.
en-copyright=
kn-copyright=

en-aut-name=DeguchiSeigo
en-aut-sei=Deguchi
en-aut-mei=Seigo
kn-aut-name=出口静吾
kn-aut-sei=出口
kn-aut-mei=静吾
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Long-term bone marrow culture
kn-keyword=Long-term bone marrow culture
en-keyword=Human marrow stromal cells
kn-keyword=Human marrow stromal cells
en-keyword=Aging
kn-keyword=Aging
en-keyword=Growing dynamics
kn-keyword=Growing dynamics
en-keyword=Cytokine production
kn-keyword=Cytokine production
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=7-8
article-no=
start-page=749
end-page=757
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Role of sigma sites in the modulation of neuroleptics-induced dystonia in rats
kn-title=抗精神病薬によるジストニアの発現機序に関する実験的研究―σ (sigma) sites の関与について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recent findings have suggested that neuroleptics exhibit a strong affinity for not only dopamine receptors, but also the sigma sites. Therefore, some clinical or adverse effects of neuroleptics may be due to their action on the sigma sites. This study showed that intrarubral microinjection of 1,3-di-o-tolylguanidine (DTG) or (＋) -3- (3-hydroxyphenyl) -N-1-propyl) piperidine, sigma ligands, and several neuroleptics such as haloperidol caused dystonic reactions in rats resembling tha acute dystonic reaction in humans. The intensity and duration of the dystonia induced by these drugs showed a correlation with their affinities for the sigma sites. These findings raise the possibility that the acute dystonic reaction, one of the motor side effects of neuroleptics, might be mediated via the sigma sites. On the other hand, BMY 14802, an atypical neuroleptic, never caused dystonia after intrarubral microinjection. Furthermore, BMY 14802 still inhibited the dystonia induced by intrarubral microinjection of DTG. This reduction in DTG-induced dystonia by BMY 14802 may result its direct inhibitory effects against DTG at the sites, because BMY 14802 possesses potent sigma affinty. These findings imply that sigma ligands may be divided into two categories, dystonia-reinforcing and -reducing groups. Application of this theory should lead to the elucidation of the mechanism of neuroleptics-induced dystonia and other motor side effects.
en-copyright=
kn-copyright=

en-aut-name=OkumuraKazuya
en-aut-sei=Okumura
en-aut-mei=Kazuya
kn-aut-name=奥村一哉
kn-aut-sei=奥村
kn-aut-mei=一哉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=sigma sites
kn-keyword=sigma sites
en-keyword=dystonia
kn-keyword=dystonia
en-keyword=1, 3 -di-o-tolylguanidine (DTG)
kn-keyword=1, 3 -di-o-tolylguanidine (DTG)
en-keyword=BMY 14802
kn-keyword=BMY 14802
en-keyword=neuroleptics
kn-keyword=neuroleptics
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=5-6
article-no=
start-page=437
end-page=445
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical studies on atypical leukemia Part 2. Clinical effects of low-dose (4)N-Behenoyl-β-D-Arabinofuranosylcytosine(BHAC) therapy on atypical leukemia
kn-title=非定型的白血病の病態並びに治療に関する研究　第2編　非定型的白血病の治療に関する検討：(4)N-behenoyl-1-β-D-arabinofuranosyl-cytosine(BHAC) 少量療法の臨床効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Therapeutic effects of low-dose (4)N-Behenoyl-β-D-Arabinofuranosylcytosine(BHAC) on 52 patients with hypoplastic leukemia were analyzed to establish the optimal clinical management of hypoplastic leukemia. Among 8 patients treated with a low-dose (4)N-Behenoyl-β-D-Arabinofuranosyl cytosine (LD-BHAC) regimen, in which 50mg BHAC was administered daily intravenously by one-hour drip infusion for 14 days, 4 patients obtained complete remission (CR) and 2 patients obtained partial remission (PR). The response rate (CR+PR) was 75%. The responders were all over 65 years old. Although  hematological toxicities and adverse effects on the digestive system such as anorexia and nausea were observed, they were all controllable by conventional treatments. The serum concentrations of ara-C were measured in 4 patients. Serum ara-C reached the peak concentration, 3.62-18.9 ng/ml (mean : 11.74 ng/ml), at the cessation of BHAC infusion, and a serum ara-C level of 2.75-4.89 ng/ml (mean : 3.54 ng/ml) was still present 6 hours after the cessation of infusion. Among 44 patients hospitalized before 1984, 27 patients were treated with blood transfusion and /or single antileukemic agent and 17 patients received combination chemotherapeutic regimens. Only 8 of 44 patients attained CR. The responders were all below 65 years old, and except for one patient, received combination chemotherapy. These results suggest that LD-BHAC therapy is useful in the clinical management of hypoplastic leukemia as a remission induction chemotherapy.
en-copyright=
kn-copyright=

en-aut-name=NakadaHiroshi
en-aut-sei=Nakada
en-aut-mei=Hiroshi
kn-aut-name=仲田浩之
kn-aut-sei=仲田
kn-aut-mei=浩之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=atypical leukemia
kn-keyword=atypical leukemia
en-keyword=therapy of hypoplastic leukemia
kn-keyword=therapy of hypoplastic leukemia
en-keyword=low dose behenoyl-ara-C therapy
kn-keyword=low dose behenoyl-ara-C therapy
en-keyword=behenoyl-ara-C
kn-keyword=behenoyl-ara-C
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=3-4
article-no=
start-page=325
end-page=334
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=1994
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Enhancement of anti-tumor activity of 1-β-D-arabinofuranosyl-cytosine
kn-title=1-β-D-arabinofuranosyl-cytosineの抗腫瘍効果増強に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1-β-D-arabinofuranosyl-cytosine (ara-C) is one of the most effective agents in the chemo-therapy of acute non-lymphocytic leukemia (ANLL). Herein, the effects of uracil(U), deoxyuridine (UdR) and uridine (UR) on the anti-tumor activity of ara-C and on ara-C accumulation in the cells were studied. Growth-inhibition activities of ara-C alone and in combination with U, UdR and UR were determined by the trypan blue method. Cell-killing activities against MOLT-4, HL60, human leukemic progenitors (L-CFU) and human colony forming units (G-CSF) were determined by a colonogenic assay. The growth-inhibition activity of ara-C against MOLT-4 and HL60 was not enhanced by U or UdR. On the other hand, 10(-3)mol UR enhanced the growth-inhibition activity of ara-C against both MOLT-4 and HL60. The 50% inhibition dose (ID50) of ara-C was 6.0×10(-7)mol for MOLT-4 and 4.0×10(-7)mol for MOLT-4 and HL60. On the other hand, in the culture medium containing 10(-3)mol UR ID50 was 3.0×10(-8)mol for MOLT-4 and HL60. Cell-killing acticvity of ara-C was enhanced by 10(-3)mol UR. The 50% lethal dose (LD50) of ara-C for MOLT-4 and HL60 was decreased from 9.0×10(-7)mol to 5.0×10(-8)mol and from 5.0×10(-7)mol to 5.0×10(-8)mol after a 72-hour exposure to 10(-3)mol of UR, respectively. Cell-killing activity of ara-C against L-CFU was enhanced by 10(-3)mol UR in 4 of the 9 ANLL patients. On the other hand, the cell-killing activity of ara-C against G-CSF was enhanced in 2 of the 9 healthy individuals. 10(-8)mol ara-C, UR enhanced the cell-killing activity against L-CFU in 2 of the 9 ANLL patients, but not for G-CSF. Accumlation of (3)H-sra-C in MOLT-4 cells at 12, 24 and 48 hours was significantly increased in culture medium containing 10(-8)mol of (3)H-ara-C and 10(-3)mol of UR. Accumulation of 3H-ara-C in HL60 cells at 24 and 48 hours was also significantly increased. It is noteworthy that the cell-killing activity of ara-C against not only human lymphoid and myeloid leukemic cell lines but also L-CFU was enhanced by the combination with a nucleoside (UR), but not with anti-lrukemic agents. These findings provide some information on the enhancement of the anti-tumor activity and mechanims of resistance of ara-C.
en-copyright=
kn-copyright=

en-aut-name=HayashiNaoki
en-aut-sei=Hayashi
en-aut-mei=Naoki
kn-aut-name=林直樹
kn-aut-sei=林
kn-aut-mei=直樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=1-β-D-arabinofuranosyl-cytosine
kn-keyword=1-β-D-arabinofuranosyl-cytosine
en-keyword=cytosine arabinoside
kn-keyword=cytosine arabinoside
en-keyword=uridine
kn-keyword=uridine
en-keyword=enhancement of antitumor effect
kn-keyword=enhancement of antitumor effect
en-keyword=in vitro chemotherapy
kn-keyword=in vitro chemotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=1-2
article-no=
start-page=217
end-page=226
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effects of MCI-186 for ischemic-reperfusion injury during cardiopulumonary bypass
kn-title=新しい free radical scavenger MCI-186 の心筋保護効果に関する実験的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine the efficacy of MCI-186, a novel free radical scavenger, in ischemia-reperfusion injury during cardiopulumonary bypass (CPB), the following experimental model was applied. Twenty-one mongrel dogs were subjected to 120 minutes of hypothermic global ischemia by aortic cross clamping with intermittent administration of a cardioplegic solution followed by 60 minutes reperfusion. They were assingend to three groups : group A(n=7), no drug was administerd before reperfusion ; group B(n=7), 1ml/kg of physiological saline was administered by bolus injection through the aortic root just before reprefusion ; group C(n=7), MCI-186 (3mg/ml/kg) dissolved in physiological saline was administered in the same manner as group B. Cardiac function (left ventricular systolic pressure, cardiac output, left ventricular maximum dP/dt) after 60 minutes reperfusion expressed as as percent recovery of pre-ischemic state was superior in group C than in groups A and B. Release of lipidperoxide assayed by the TBA method as the difference between coronary artery and sinus were suppressed in the early phase of reperfusion in group C. Myocardial water content after 60 minutes reperfusion was also less in group C than in group A and B. These findings suggest that administration of MCI-186 before reprefusion after ischemia is effective in protecting the heart from ischemia-reperfusion injury.
en-copyright=
kn-copyright=

en-aut-name=TakeoMasahiko
en-aut-sei=Takeo
en-aut-mei=Masahiko
kn-aut-name=竹尾正彦
kn-aut-sei=竹尾
kn-aut-mei=正彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=MCI-186
kn-keyword=MCI-186
en-keyword=再灌流障害
kn-keyword=再灌流障害
en-keyword=free radical
kn-keyword=free radical
en-keyword=心筋保護
kn-keyword=心筋保護
en-keyword=体外循環
kn-keyword=体外循環
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=1-2
article-no=
start-page=205
end-page=216
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of lithium carbonate on brain injury induced by complete global brain ischemia in dogs
kn-title=完全全脳虚血後の脳障害に対する炭酸リチウムの効果に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The efficacy of lithium carbonate (Li) in preventing ischemic brain injury was evaluated in 36 dogs in a vegetative state. The dogs were subjected to 18 minutes of complete global brain ischemia and diveded into the following three groups ; control group (n=12), L-Ⅰ group (n=12), and L-Ⅱ group (n=12). In the L-Ⅰand L-Ⅱgroups, dogs were administered Li (10mg/kg) immediately after the end of ischemia (post-treatment). Only in the L-Ⅱ group, dogs were administered Li (100mg/kg) orally one day before the ischemic insult (pre-treatment). In each group, nuerologic outcome was evaluated for seven days after ischemia, and morphological changes in hippocampal CA1 pyramidal cells, small to medium-sized striatal neurons and cerebellar Purkinje cells were evaluated at day seven. In the L-Ⅱ group, neutrologic outcome was significantly better than that in the control group, and morphological improvement was recognized. Pre-treatment with Li might improve both neurologic and morphologic outcomes due to powerful inhibition of the stimulated phosphoinositide turnover during ishchemia. These fingings suggest that the stimulated phosphoinositide turnover during and immediately after ischemia might play an important role in brain injury induced by 18 minutes of complete global brain ischemia.
en-copyright=
kn-copyright=

en-aut-name=YaidaYutaka
en-aut-sei=Yaida
en-aut-mei=Yutaka
kn-aut-name=八井田豊
kn-aut-sei=八井田
kn-aut-mei=豊
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=完全全脳虚血
kn-keyword=完全全脳虚血
en-keyword=イノシトールリン脂質作動系
kn-keyword=イノシトールリン脂質作動系
en-keyword=炭酸リチウム
kn-keyword=炭酸リチウム
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=771
end-page=778
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Flowcytometric studies of effects of heat on DNA synthesis in different thermosensitivities mammalian cell lines
kn-title=温熱感受性の異なる培養細胞の DNA 合成に対する温熱効果―フローサイトメトリーによる研究―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effect of heat on DNA synthesis in HeLa S3 cells and L-5 cells was studied using flowcytometry. When D(0) values obtained from survival curves of Ehrlich ascites tumor cells, L-5 cells, HeLa S3 cells and NIH3T3 cells after heating to 43, 44, or 45℃, were compared, HeLa S3 cells were resistant and L-5 cells were sensitive to heating. During heating at 43℃, DNA synthesis (BUdR uptake) of HeLa S3 cells was resistant compared to that of L-5 cells. When the period of DNA synthesis was divided into 3 fractions (early S, mid S and late S), late S phase was the most sensitive fraction to heating at 43℃ for 60 minutes. From these results, relationship between DNA synthesis and thermocytotoxic effects are discussed.
en-copyright=
kn-copyright=

en-aut-name=TanakaSeiryou
en-aut-sei=Tanaka
en-aut-mei=Seiryou
kn-aut-name=田中聖了
kn-aut-sei=田中
kn-aut-mei=聖了
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
en-keyword=Flowcytometry
kn-keyword=Flowcytometry
en-keyword=DNA synthesis
kn-keyword=DNA synthesis
en-keyword=Heating
kn-keyword=Heating
en-keyword=BUdR
kn-keyword=BUdR
END

start-ver=1.4
cd-journal=joma
no-vol=55
cd-vols=
no-issue=9
article-no=
start-page=707
end-page=713
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20061117
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of Computer-Controlled Flow Injection Instruments and Its Application to Determination of Nitrate, Nitrite, and Ammonium Ions in Environmental Samples
kn-title=コンピュータ制御されたフローインジェクション分析装置の開発と環境水中の硝酸イオン，亜硝酸イオン，アンモニウムイオン定量への応用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Flow injection analysis (FIA) systems with low power consumption and personal-computer control were developed by using solenoid pumps and an LED detector. Both programs for controlling the system and acquiring measurement data were written using LabVIEW. The FIA system was applied to the determination of nitrite ion in river-water samples based on diazotization and coupling reactions. Linear calibration graphs were obtained with the combination of pump(s) and photometric detector in the concentration range of nitrite ion at 0.5∼3.0 × 10−6 M. Nitrate and nitrite ions were also determined simultaneously by the system by using a Cd/Cu reduction column and a by-pass flow. Determination of ammonia in river-water samples was also realized by the system with a modified indophenol reaction.
en-copyright=
kn-copyright=

en-aut-name=JoichiYasutaka
en-aut-sei=Joichi
en-aut-mei=Yasutaka
kn-aut-name=城市康隆
kn-aut-sei=城市
kn-aut-mei=康隆
aut-affil-num=1
ORCID=

en-aut-name=NarongLenghor
en-aut-sei=Narong
en-aut-mei=Lenghor
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=高柳俊夫
kn-aut-sei=高柳
kn-aut-mei=俊夫
aut-affil-num=3
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=4
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=5
ORCID=

en-aut-name=UraNobuo
en-aut-sei=Ura
en-aut-mei=Nobuo
kn-aut-name=浦信夫
kn-aut-sei=浦
kn-aut-mei=信夫
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学理学部化学科

affil-num=2
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻

affil-num=3
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻

affil-num=4
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻

affil-num=5
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻

affil-num=6
en-affil=
kn-affil=株式会社相馬光学
en-keyword=Flow injection analysis
kn-keyword=Flow injection analysis
en-keyword=LabVIEW control
kn-keyword=LabVIEW control
en-keyword=solenoid pumps
kn-keyword=solenoid pumps
en-keyword=nitrate ion
kn-keyword=nitrate ion
en-keyword=nitrite ion
kn-keyword=nitrite ion
en-keyword=ammonia
kn-keyword=ammonia
END

start-ver=1.4
cd-journal=joma
no-vol=55
cd-vols=
no-issue=9
article-no=
start-page=715
end-page=720
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20061117
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Highly Efficient and Automatic Collection/Concentration with Chelating Resin for Inductively Coupled Plasma Atomic Emission Spectroscopy
kn-title=誘導結合プラズマ発光分析のためのキレート樹脂を用いる高効率自動前処理濃縮
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An automatically controlled collection/concentration system for ICP-AES was developed. Elements were collected with small chelating disks and chelating resin with the iminodiacetate moiety packed in a line filter. This column was installed in a 6-way valve on the pretreatment system, which could be connected on line to ICP-AES. The flow rate was 1 ml min−1 and conditioning of the chelating disk was carried out by flowing 0.5 M ammonium acetate (pH 5.5) for 2 min, sampling for 5 min and washing for 1 min. Elution was done by passing through 2 M HNO3 at 1.3 ml min−1 for 1 min. Bi, Cd, Co, Cr, Cu, Mn, Ni, Pb and V could be determined with 5.0 ml of the sample solution. The enrichment factors were 3∼15 times and the collection efficiencies were better than 80%. The detection limits (LOD) were from 0.003 for Mn to 0.311 for Bi, which were several 10 to 100-times lower than that of normal LOD of ICP-AES. This method was successfully applied to the determination of these metals in tap and river-water samples.
en-copyright=
kn-copyright=

en-aut-name=YamamotoTakako
en-aut-sei=Yamamoto
en-aut-mei=Takako
kn-aut-name=山本貴子
kn-aut-sei=山本
kn-aut-mei=貴子
aut-affil-num=1
ORCID=

en-aut-name=AkhmadSabarudin
en-aut-sei=Akhmad
en-aut-mei=Sabarudin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NoguchiOsamu
en-aut-sei=Noguchi
en-aut-mei=Osamu
kn-aut-name=野口修
kn-aut-sei=野口
kn-aut-mei=修
aut-affil-num=3
ORCID=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=高柳俊夫
kn-aut-sei=高柳
kn-aut-mei=俊夫
aut-affil-num=4
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=5
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学理学部化学科

affil-num=2
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻

affil-num=3
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻

affil-num=4
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻

affil-num=5
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻

affil-num=6
en-affil=
kn-affil=岡山大学大学院自然科学研究科機能分子化学専攻
en-keyword=automated collection/concentration
kn-keyword=automated collection/concentration
en-keyword=chelating disk and chelating resin
kn-keyword=chelating disk and chelating resin
en-keyword=ICP-AES
kn-keyword=ICP-AES
en-keyword=heavy metals
kn-keyword=heavy metals
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=9-10
article-no=
start-page=1073
end-page=1084
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of zinc on halothane-induced liver injury in rats
kn-title=ラットにおけるハロタン肝障害に及ぼす亜鉛の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In a rat model, halothane causes liver injury by reductive interaction with microsomal cytochrome P-450 (P-450) and /or by a hepatotoxic effect mediated by halothane-derived free radicals. Rats that were pretreated with phenobarbital (0.1% in drinking water for 6 days) and fasted for the last day, then exposed to halothane (1.0%) under reduced oxygen tension (14%) for 2 horus developed hepatic centrilobular necrosis with marked elevation in serum GPT (GPT) 24 h after exposure. Pretreatment with a 5 mg/kg dose of zinc (Zn) 24 h prior to the exposure had no effect on GPT and liver necrosis. However, 10mg/kg and 20 mg/kg of Zn significantly decreased GPT and liver necrosis. Zn-pretreatment (5-20 mg/kg) significantly depleted hepatic microsomal P-450 before exposure in a dose dependent manner. Hepatic metallothionein (MT)-1 and MT-2 induced by Zn in a dose dependent manner and the levels did not significanlty differ prior to and after exposure to halothane under hypoxic conditions in all Zn-pretreated groups of rats. These results indicated that Zn-pretreatment has some protective effect against halothane-induced liver injury and suggested that this protective effect of Zn involves the depletion of P-450 which results in reduced interacton between P-450 and halothane in the microsomes and is not the result of MTs acting as free radical scavengers.
en-copyright=
kn-copyright=

en-aut-name=HidakaHidekuni
en-aut-sei=Hidaka
en-aut-mei=Hidekuni
kn-aut-name=日高秀邦
kn-aut-sei=日高
kn-aut-mei=秀邦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=ハロタン
kn-keyword=ハロタン
en-keyword=肝障害
kn-keyword=肝障害
en-keyword=亜鉛
kn-keyword=亜鉛
en-keyword=チトクローム P-450
kn-keyword=チトクローム P-450
en-keyword=メタロチオネイン
kn-keyword=メタロチオネイン
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=9-10
article-no=
start-page=1035
end-page=1051
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study of L-Dopa induced abnormal involuntary movements in monkey
kn-title=サルの L-Dopa 誘発不随意運動に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hypokinesia in the unilateral limbs was induced in 8 monkeys (Macaca fuscata fuscata) by a lesion in the contralateral mesencepahlic ventromedial tegmentum (VMT). Daily oral administration of L-Dopa/carbidopa (40mg/kg, 4mg/kg) relieved the hypokinesia and thereafter induced continuous abnormal (choreo-athetoid) involuntary movements (AMI) in upper and lower limbs contralateral to the lesion. These movements were always uniform and continued for a few hours. The author performed a series of pharmacological studies using these VMT-lesioned monkeys. 1) Direct injection of dopamine (500-1000μg/10μl) and apomorphine (500-1500μg/10μl)into the dorsomedial part of the head of the caudate nucleus ipsilateral to the VMT lesion induced the same AIM as those induced by oral administration of L-Dopa/carbidopa. However, intraputaminal injection of these agents induced AIM in bucco-lingual region only. 2) After oral administration of L-Dopa/cabidopa, direct injection of methionine-enkephalin (300μg/10μl), GABA (500-1000μl/10μl) and serotonin (100-200μg/10μl) into the dorsomedial part of the head of the caudate nucleus (HCN) slightly decreased the AIM. However, substance p(200-400μg/10μl) or atropine (100-200μg/10μl) had no effect on the AIM. Neither the direct injection of GABA (500-1000μg/10μl) nor substance P (200-400μg/10μl) into the internal segment of the globus pallidus had any effect of the AIM. 3) The dopaminergic receptor (DA-2) binding study was performed on caudate tissues which were removed 5 weeks after creating the lesion in the unilateral VMT. DA-2 receptor binding of the dorsomedial part of the caudate nucleus, ipsilateral to the lesion, had a higher affinity than that of the ipsilateral ventrolateral part or the contralateral caudate tissue.
These results suggest that denervation supersensitivity of the post-synaptic DA-2 receptors in the dorsomedial part of the caudate nucleus is a basic condition for the development of L-Dopa induced AIM, and the postdopaninergic neuronal systems in the caudate nucleus are slightly suppressed by the intra-caudate neurons, of which transmitter substances are methionine-enkephalin, GABA and serotonin.
en-copyright=
kn-copyright=

en-aut-name=SakuraiMasaru
en-aut-sei=Sakurai
en-aut-mei=Masaru
kn-aut-name=桜井勝
kn-aut-sei=桜井
kn-aut-mei=勝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科学教室
en-keyword=L-Dopa
kn-keyword=L-Dopa
en-keyword=involuntary movement
kn-keyword=involuntary movement
en-keyword=striatum
kn-keyword=striatum
en-keyword=centrally acting agents
kn-keyword=centrally acting agents
en-keyword=dopaminergic receptor
kn-keyword=dopaminergic receptor
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=9-10
article-no=
start-page=963
end-page=971
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The clinical features and pathogenesis of premenstrual asthma : Effect of progesterone and β-estradiol on lymphocyte activation
kn-title=月経喘息の臨床的意義とその発症機序に関する研究―リンパ球機能に及ぼす影響を中心に―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although premenstrual worsening of asthma is recognized, little is known about the pathophysiology. Monthly variation in endogenous progesterone and β-estradiol may be associated with the etiology of premenstrual asthma (PMA). T lymphocytes play an importanat role in the pathogenesis of asthma. Therefore, to clarify the pathogenesis of PMA, the clinical features and effects of progesterone and β-estradiol on lymphocyte activation were studied. 1) Thirty one asthmatic females of reproductive age were surveyed. Fourteen asthmatics (45%) claimed their asthma symptoms worsened just prior to or during the menses. Comparing asthmatics with and without PMA, the former group showed significantly more severe steroid dependent asthma. 2) Progesterone and β-estradiol suppressed lymphocyte blastogenesis stimulated by phytohemagglutinin (PHA), mite and Candida antigen. There was no significant difference in the suppression rate between asthmatics and normal subjects, or between male and female. These findings suggest that T lymphocytes may be activated by causal allergens when progesterone and β-estradiol levels decrease during the premenstrual period. Activated T lymphocytes may contribute to the pathogenesis of PMA.
en-copyright=
kn-copyright=

en-aut-name=GotoMotoko
en-aut-sei=Goto
en-aut-mei=Motoko
kn-aut-name=後藤基子
kn-aut-sei=後藤
kn-aut-mei=基子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Premenstrual asthma
kn-keyword=Premenstrual asthma
en-keyword=T-cell
kn-keyword=T-cell
en-keyword=Progesterone
kn-keyword=Progesterone
en-keyword=β-estradiol
kn-keyword=β-estradiol
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=9-10
article-no=
start-page=947
end-page=962
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Low dose melphalan for myelodysplastic syndrome
kn-title=骨髄異形成症候群における melphalan 少量療法の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Myelodysplastic syndrome (MDS) is a disorder of multipotential hematopoietic stem cells. There is no effective therapy for MDS, especially for MDS associated with an excess of blasts, such as refractory anemia with excess blasts (RAEB) or RAEB in transformation (RAEBt). We previously reported the effect of K-18 (a human IgG-melphalan conjugate) in 15 patients with RAEB or RAEBt. The overall response rate was not high, but no side effects were noted. Although the mode of action of K-18 is not certain, it was suggested that the effect was associated with the activity of melpahlan itself. Therefore, low-dose melphalan therapy was initiated in eldery patients with RAEB or RAEBt. Six patients with RAEB and 12 patients with RAEBt received 2mg oral administration daily. Median age of the patients was 64. Six patients achieved complete remission (CR), one patient showed a partial response and four patients had a minor response. Total dosage of melpahlan for patients who achieved CR was 143±18 mg. Median duration of CR was 14.5 months. Serious toxicity was not encountered in any case and neither marrow suppression nor pancytopenia were observed in cases that achieved CR during the administration of melphalan. Changes in cell surface markers (CD34, CD33, CD13) were examined during the time course of CR in two cases. CD34 + cells decreased rapidly during the first two weeks and CD34-CD33+cells increased after four weeks of melpahlan administration. Studying the clinical course of CR with cell surface marker analysis provided evidence that melphalan therapy induced differentiation of transformed hemopoietic precursors.
We conclude that daily chronic administration of melpahlan is a useful therapy for elderly patients with RAEB or RAEBt.
en-copyright=
kn-copyright=

en-aut-name=TakabaSeiji
en-aut-sei=Takaba
en-aut-mei=Seiji
kn-aut-name=高場成治
kn-aut-sei=高場
kn-aut-mei=成治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=RAEB
kn-keyword=RAEB
en-keyword=RAEBt
kn-keyword=RAEBt
en-keyword=low dose melpahlan therapy
kn-keyword=low dose melpahlan therapy
en-keyword=CD34
kn-keyword=CD34
en-keyword=CD33
kn-keyword=CD33
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=1-2
article-no=
start-page=93
end-page=102
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hypoplastic leukemia : Chemotherapy for bone marrow dyslasia
kn-title=低形成型白血病に関する臨床的研究―血球形態異常と化学療法効果との関連―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effect of chemotherapy on dysplasia of bone marrow cells was studied in 10 patients with hypoplastic leukemia. Patients were all previously untreated, and ages ranged from 40 to 81 years old (median : 70). Male to female ratio was 1 : 1. Morphologic features studied were pseudo-Pelger neutrophils, absence or decreased Azur granules in the neutrophilis, multinu-cleated erythroblasts, megaloblastoid changes in erythroblasts, micromegakaryocytes, mononuclear megakaryoctes and megekaryocytes with multiple small separated nulei. Although 8 patients with chemotherapeutic effect showed little evidence of dysplasia, 2 patients without chemotherapeutic effect showed severe dysplasia in two or three blood cell lineages. These findings sre thought to indicate that a part of hypoplastic leukemia develops from myelodysplasia with hypoplastic marrow. The establishment of an optimal treatment for hypoplastic leukemia should be sytudied by stratification of bone marrow dysplasia.
en-copyright=
kn-copyright=

en-aut-name=FukudaShunichi
en-aut-sei=Fukuda
en-aut-mei=Shunichi
kn-aut-name=福田俊一
kn-aut-sei=福田
kn-aut-mei=俊一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=hypoplastic leukemia
kn-keyword=hypoplastic leukemia
en-keyword=dysplasia of blood cells
kn-keyword=dysplasia of blood cells
en-keyword=chemotherapy
kn-keyword=chemotherapy
en-keyword=scoring system
kn-keyword=scoring system
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=7-8
article-no=
start-page=907
end-page=915
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199408
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Establishment of antigen specific T cell clones from asthmatic patients including evaluation of cytokine production
kn-title=気管支喘息における抗原特異的 T cell clone の樹立とサイトカイン産生能に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the pathogenesis of bronchial asthma, we establishied T cell clones specific for Candida antigen and for mite antigen from the peripheral blood of three asthmatic patients. Flow cytometric analysis was performed on these clones. The surface phenotype of all clones was helper/inducer type. These clones were analyzed for the ability to produce interferon gammma (IFN-γ) and interleukin 4 (IL-4). The T cell clone established from tne patient who showed late asthmatic response (LAR) after bronchial inhalation of Candida, as well as the clones from the patient who showed IAR and LAR after inhalation of housedust mite, produced a higher amount of IFN-γ and lower amount of IL-4. The T cell clone established from the patient who were under corticosteroid therapy and showed IAR after inhalation of Candida produced lower amounts of IFN-γ and IL-4, which seemed to be inhibition of cytokine production from antigen specific T cell clone by corticosteroids. These findings indicate that T cell clones established from the patients who showed LAR produced a large amount of IFN-γ, suggesting that IFN-γ plays an important role in allergic reactions of LAR.
en-copyright=
kn-copyright=

en-aut-name=MiyaharaNobuaki
en-aut-sei=Miyahara
en-aut-mei=Nobuaki
kn-aut-name=宮原信明
kn-aut-sei=宮原
kn-aut-mei=信明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=antigen specific T cell clone
kn-keyword=antigen specific T cell clone
en-keyword=IFN-γ
kn-keyword=IFN-γ
en-keyword=bronchial asthma
kn-keyword=bronchial asthma
en-keyword=late asthmatic response (LAR)
kn-keyword=late asthmatic response (LAR)
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=7-8
article-no=
start-page=811
end-page=823
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199408
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Induction of renal metallothionein in ischemic acute renal failure in the rat
kn-title=ラット虚血性急性腎不全における腎内メタロチオネインの誘導
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the functions of the renal metallothioneins (MTs) in rats following ischemic acute renal failure, the expression of MT mRNA and the localization of MT in rats undergoing 60 min of bilateral renal artery clamp ischemia followed by reperfusion was examined by Northern blot analysis, in situ hybridization and immunohistochemical analysis. Induction of maximum at 1 to 3 days followed by a gradual decrease. Histlogically, both MT mRNA and MT were detected in renal tubular cells intensely and specifically in the outer medulla at 1 day after release of the clamp. These findings suggest that MTs protect the tubular cells by scavenging the free radicals, which probably cause renal tubular cell damage by ischemia-reperfusion, and that MTs provide the zinc ions to zinc-requiring apo-enzymes necessary for healing and regenerating renal tubular cells.
en-copyright=
kn-copyright=

en-aut-name=HaradaKeiko
en-aut-sei=Harada
en-aut-mei=Keiko
kn-aut-name=原田圭子
kn-aut-sei=原田
kn-aut-mei=圭子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=虚血性急性腎不全
kn-keyword=虚血性急性腎不全
en-keyword=メタロチオネイン
kn-keyword=メタロチオネイン
en-keyword=in situ hybridization
kn-keyword=in situ hybridization
en-keyword=免疫組織化学染色
kn-keyword=免疫組織化学染色
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=1-2
article-no=
start-page=13
end-page=29
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960229
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The expansion and antitumoral activity of recombinant IL-2 activated tumor infiltrating lymphocytes from human cancers
kn-title=腫瘍内浸潤リンパ球の rIL-2 添加培養と細胞傷害活性の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Tumor infiltrating lymohocytes (TIL) were isolated from various human cancers and cultured. The expansion, cytotoxicity, phenotype, and perforin, which is considered the cytotoxic factor of killer cells, of TIL were examinel. TIL cultured in 1000u/ml recombinant interleukin-2 (rIL-2) with 20% conditioned medium (CoM) exhibited far better expansion capability than that of TIL cultured in rIL-2 1000u/ml alone, and continued to expand up to 14 weeks. The maximal expansion index (EI) was 23912. When TIL arrested expansion during the culture, the addition of PHA restored the ability to expand. The CoM was composed of spent medium from a 3-day culture of peripheral blood mononuclear cells from cancer patients. The lymphokine-activated killer (LAK) cells induced by the culture was utilized for clinical adoptive immunotherapy in our department. Cytotoxicity against K562 and Daudi target cells was highest at 2 to 3 weeks, and disappeared between 4 and 7 weeks of culture. The phenotype of fresh TIL was mainly CD3(+) T cells, predominantly CD4(+) cells, but CD8(+) cells became predominant in long term culture. The frequency of IL-2R(+) and HLA-DR+ cells was correlated with the expansiveness of TIL. The appearance and intensity of perforin positive cells were associated with the level of cytotoxicity of cultured TIL.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoMitsuaki
en-aut-sei=Matsumoto
en-aut-mei=Mitsuaki
kn-aut-name=松本三明
kn-aut-sei=松本
kn-aut-mei=三明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=腫瘍内浸潤リンパ球
kn-keyword=腫瘍内浸潤リンパ球
en-keyword=recombinant interleukin-2
kn-keyword=recombinant interleukin-2
en-keyword=細胞傷害活性
kn-keyword=細胞傷害活性
en-keyword=リンパ球表面抗原
kn-keyword=リンパ球表面抗原
en-keyword=パーフォリン
kn-keyword=パーフォリン
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=7-8
article-no=
start-page=241
end-page=252
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hemodynamic and hormonal changes under the biventricular bypass system with ventricular fibrillated hearts
kn-title=心室細動下両心バイパス型人工心臓における循環及び内分泌動態の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hemodynamic and hormonal changes were studied in 13 sheep whose entire circulation was maintained by a biventricular bypass system with a pair of pusher-plate type blood pumps. Ventricular fibrillation was induced and pneumatically driven pumps placed outside the body kept the animals alive for 2-48 days (average: 11 days). Pump output and aortic pressure stayed within physiological ranges, but central venous pressure was elevated from 5 to 10-13 ㎜Hg after surgery. Serum levels of antidiuretic hormone, cortisol and insulin were stabilized soon after surgery. Adrenaline level and renin activity did not change significantly. For unknown reasons, the noradrenaline level showed a temporary increase after a week. Atrial natriuretic peptide (ANP) increased significantly 5 days after surgery. There were significant drops in triiodothyronine (T(3)) and thyroxine (T(4)) levels after surgery with gradual recovery afterward to 40% and 50% of the control levels, respectively. These results suggested that the biventricular bypass system maintained hemodynamic conditions similar to those maintained by the natural heart, although ANP, T(3) and T(4) values were changed.
en-copyright=
kn-copyright=

en-aut-name=NakayamaHironobu
en-aut-sei=Nakayama
en-aut-mei=Hironobu
kn-aut-name=中山裕宣
kn-aut-sei=中山
kn-aut-mei=裕宣
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=左右非同期 variable rate mode
kn-keyword=左右非同期 variable rate mode
en-keyword=両心バイパス型人工心臓
kn-keyword=両心バイパス型人工心臓
en-keyword=甲状腺ホルモン
kn-keyword=甲状腺ホルモン
en-keyword=心房性ナトリウム利尿ペプタイド
kn-keyword=心房性ナトリウム利尿ペプタイド
END

start-ver=1.4
cd-journal=joma
no-vol=107
cd-vols=
no-issue=7-8
article-no=
start-page=91
end-page=98
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19950831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immobilization stress affected free radicals, superoxide dismutase activity and thiobarbituric acid reactive substances in the rat brain
kn-title=拘束スレレスのラット脳内フリーラジカル, スーパーオキシドジスムターゼ活性およびチオバルビツール酸反応物質への影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Immobilization stress for 6 hours induced hemorrhagic erosion in the rat stomach. Hydroxyl radicals singnificantly increased in the pons-medulla oblongata in stressed rats. Mitochondrial superoxide dismutase (SOD) activity was enhanced in the midbrain but was lowered in the cortex, hippocampus and cerebellum in stressed rats. Thiobarbituric acid reactive substances increased by stress in the cortex and midbrain. These finding suggested that immobilization stress generated hydroxyl radicals and accelerated lipid peroxidation, and affected mitocho-drial SOD activity which may lead to neuronal damage in stressed rats.
en-copyright=
kn-copyright=

en-aut-name=OkamuraYouko
en-aut-sei=Okamura
en-aut-mei=Youko
kn-aut-name=岡村容子
kn-aut-sei=岡村
kn-aut-mei=容子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属分子細胞医学研究施設神経情報学部門
en-keyword=拘束ストレス
kn-keyword=拘束ストレス
en-keyword=ヒドロキシルラジカル
kn-keyword=ヒドロキシルラジカル
en-keyword=スーパーオキシドジスムターゼ活性
kn-keyword=スーパーオキシドジスムターゼ活性
en-keyword=チオバルビツール酸反応物質
kn-keyword=チオバルビツール酸反応物質
en-keyword=脳
kn-keyword=脳
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=3-6
article-no=
start-page=65
end-page=69
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960629
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Pathogenesis of nystagmus ⑵ Measuring eye movements with video image processing technique
kn-title=眼振の病態生理の研究―第2報 ビデオ画像処理による眼球運動計測―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A high speed video system was compared with a conventional video system for measuring saccadic eye movements to evaluate temporal and spatial profiles of these measurements. Video image processing techniques are used to determine the pupil center, and this consequently provided a spatial resolution better than that of one diode of a charge-coupled device (CCD). Although the spatial resolution of both systems is influenced by pupil size and intensity of illumination, spatial resolution in practice is equal to 0.1 to 0.2 degree. Compared to the conventional video system, the high speed video system with a video frame rate of 1000 frames per second offers a marked improvement in temporal resolution for evaluating saccadie eye movements. Each eye being illuminated by an infrared light source with nothing attached to the eye, this video system measurement allows the subject to fixate and follow an object of regard without being disturbed. Therefore, the high speed video recordings and processing techniques have proved to be useful method for analyzing saccadic eye movement.
en-copyright=
kn-copyright=

en-aut-name=OkayamaHideki
en-aut-sei=Okayama
en-aut-mei=Hideki
kn-aut-name=岡山英樹
kn-aut-sei=岡山
kn-aut-mei=英樹
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部眼科学教室
en-keyword=眼球運動計測
kn-keyword=眼球運動計測
en-keyword=高速ビデオシステム
kn-keyword=高速ビデオシステム
en-keyword=画像処理
kn-keyword=画像処理
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=2
article-no=
start-page=159
end-page=165
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical significance of anti-asialoglycoprotein receptor autoantibodies, detected by a capture-immunoassay, in autoimmune liver diseases
kn-title=抗原捕捉免疫測定法による抗アシアロ糖タンパク質受容体抗体の検出 ―自己免疫性肝疾患における臨床的意義―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the development of autoimmune chronic acive hepatitis (AIH), the pathogenic relevance of antimmune responses against asialoglycoprotein recepter (ASGPR) has been implicated. We have previously developed a capture enzyme-linked immunsorbent assay (ELISA) for detection of anti-ASGPR antibodies and found a high prevalence of anti-ASGPR antibodies in AIH and primary biliary cirrhosis (PBC). IN this study, to clarify the clinical singnifi-cance of the measurement of anti-ASGPR antibodies in autimmune live diseases we studied correlations between thee isotype of the anti-ASGPR antibody.In AIH, the anti-ASGPR antibody titer was positively correlated with serum γ-globulin and IgM values, but not with serum transaminase. The anti-ASGPR antibody titer in histogically-active disease with piecmeal necrosis was signififcantly higher then that in quiescent disease. The most common Isotype of anti-ASGPR antibodies detected in active AIH was IgM. We encountered a case of AIH where the tirer of IgM anti-ASGPR antibody decreased by induction of remission with steroid therapy. These results suggest that the measurement of IgM isotope anti-ASGPR antiody might be useful for the evaluation of disease activity and effects of therapy in AIH patients.
en-copyright=
kn-copyright=

en-aut-name=MorisueYoshiko
en-aut-sei=Morisue
en-aut-mei=Yoshiko
kn-aut-name=森末佳子
kn-aut-sei=森末
kn-aut-mei=佳子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Medicine and Medical Science,Okayama University Graduate School of Medicine and Dentistry
en-keyword=自己免疫性肝炎
kn-keyword=自己免疫性肝炎
en-keyword=原発性胆汁性肝硬変
kn-keyword=原発性胆汁性肝硬変
en-keyword=抗アシアロ糖タンパク質受容体抗体
kn-keyword=抗アシアロ糖タンパク質受容体抗体
en-keyword=自己抗体
kn-keyword=自己抗体
en-keyword=アイソタイプ
kn-keyword=アイソタイプ
END

start-ver=1.4
cd-journal=joma
no-vol=113
cd-vols=
no-issue=3
article-no=
start-page=235
end-page=239
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20011231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=抗体による血液腫瘍の治療
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=谷本光音
kn-aut-sei=谷本
kn-aut-mei=光音
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　病態制御科学専攻（第二内科）
en-keyword=モノクローナル抗体
kn-keyword=モノクローナル抗体
en-keyword=血液腫瘍
kn-keyword=血液腫瘍
en-keyword=CD 20
kn-keyword=CD 20
en-keyword=CD 33
kn-keyword=CD 33
en-keyword=キメラ抗体
kn-keyword=キメラ抗体
END

start-ver=1.4
cd-journal=joma
no-vol=117
cd-vols=
no-issue=3
article-no=
start-page=219
end-page=224
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20060104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Characterization and usefulness of a monoclonal antibody against human herpesvirus-7 DNA polymerase processivity factor
kn-title=ヒトヘルペスウイルス7型のDNA ポリメラーゼサブユニットに対する単クローン抗体の性状と有用性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A monoclonal antibody (MAb), IK17, was developed and found useful for the analysis of human herpesvirus-7 (HHV7) genome replication. In Western blot analysis, the MAb IK17 specifically detected an HHV7 DNA polymerase subunit,U27 protein,expressed in both Escherichia coli (E.Coli)and HHV7-infected cells.Analysis by the same method of truncated U27 proteins expressed in E. Coli demonstrated that the MAb IK17 recognizes an epitope between amino acid 1 and 133 of the U27 protein.The indirect immunofluorescence (IF)method with MAb IK17 detected an unexpected reduction of U27 protein in the infected cells that were treated with a viral DNA polymerase inhibitor,phosphonoacetic acid (PAA),although no reduction of U27 mRNA was observed in the cells by Northern blot analysis. The data suggest the possible usefulness of the MAb IK17 for obtaining clues to characterize an unknown feature of the U27 protein. Immunoprecipitation experiments with the MAb IK17 enabled to detect at least four U27 protein-associated phosphorylated polypeptides in addition to the U27 protein itself.The result indicates the usefulness of the MAb IK17 for qualitative and quantitative analysis of the U27 proteinassociated viral and cellular factors. These analyses contribute to elucidation of the HHV7 genome replication system.
en-copyright=
kn-copyright=

en-aut-name=NambaHikaru
en-aut-sei=Namba
en-aut-mei=Hikaru
kn-aut-name=難波ひかる
kn-aut-sei=難波
kn-aut-mei=ひかる
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病原ウイルス学
en-keyword=ヒトヘルペスウイルス7型 (Human Herpesvirus-7)
kn-keyword=ヒトヘルペスウイルス7型 (Human Herpesvirus-7)
en-keyword=DNA polymerase processivity factor
kn-keyword=DNA polymerase processivity factor
en-keyword=単クローン抗体 (monoclonal antibody)
kn-keyword=単クローン抗体 (monoclonal antibody)
END

start-ver=1.4
cd-journal=joma
no-vol=117
cd-vols=
no-issue=3
article-no=
start-page=199
end-page=204
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20060104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ヒストンアセチル化制御による実験的関節炎の抑制
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=西田圭一郎
kn-aut-sei=西田
kn-aut-mei=圭一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 人体構成学
en-keyword=関節リウマチ
kn-keyword=関節リウマチ
en-keyword=エピジェネティクス
kn-keyword=エピジェネティクス
en-keyword=ヒストン脱アセチル化酵素阻害剤
kn-keyword=ヒストン脱アセチル化酵素阻害剤
en-keyword=CDKインヒビター
kn-keyword=CDKインヒビター
en-keyword=抗II型コラーゲン抗体誘導関節炎
kn-keyword=抗II型コラーゲン抗体誘導関節炎
END

start-ver=1.4
cd-journal=joma
no-vol=116
cd-vols=
no-issue=3
article-no=
start-page=215
end-page=220
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=新しい核内受容体 Pregnane X Receptor の生殖生理における役割―岡山大学医学賞（林原賞）を受賞して―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=増山寿
kn-aut-sei=増山
kn-aut-mei=寿
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　産科婦人科
en-keyword=pregnane X receptor
kn-keyword=pregnane X receptor
en-keyword=steroidogenesis
kn-keyword=steroidogenesis
en-keyword=cytochrome P450
kn-keyword=cytochrome P450
en-keyword=drug resistance
kn-keyword=drug resistance
END

start-ver=1.4
cd-journal=joma
no-vol=117
cd-vols=
no-issue=2
article-no=
start-page=109
end-page=118
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=誘導性ヒスタミンはＨ(2)受容体刺激を介してP.ances-LPS 誘発性肝炎からマウスを保護する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=横山穣
kn-aut-sei=横山
kn-aut-mei=穣
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科薬理学
en-keyword=内因性ヒスタミン
kn-keyword=内因性ヒスタミン
en-keyword=サイトカイン
kn-keyword=サイトカイン
en-keyword=マウス急性肝炎
kn-keyword=マウス急性肝炎
END