start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Telomerase-specific virotherapy targeting lymph node micrometastasis of human cancer
kn-title=癌微小リンパ節転移を標的とするテロメラーゼ特異的制限増殖型ウイルス製剤の開発
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KojimaToru
en-aut-sei=Kojima
en-aut-mei=Toru
kn-aut-name=児島亨
kn-aut-sei=児島
kn-aut-mei=亨
aut-affil-num=1
ORCID=

en-aut-name=WatanabeYuichi
en-aut-sei=Watanabe
en-aut-mei=Yuichi
kn-aut-name=渡邉雄一
kn-aut-sei=渡邉
kn-aut-mei=雄一
aut-affil-num=2
ORCID=

en-aut-name=HashimotoYuuri
en-aut-sei=Hashimoto
en-aut-mei=Yuuri
kn-aut-name=橋本悠里
kn-aut-sei=橋本
kn-aut-mei=悠里
aut-affil-num=3
ORCID=

en-aut-name=KurodaShinji
en-aut-sei=Kuroda
en-aut-mei=Shinji
kn-aut-name=黒田新士
kn-aut-sei=黒田
kn-aut-mei=新士
aut-affil-num=4
ORCID=

en-aut-name=YamasakiYasumoto
en-aut-sei=Yamasaki
en-aut-mei=Yasumoto
kn-aut-name=山崎泰源
kn-aut-sei=山崎
kn-aut-mei=泰源
aut-affil-num=5
ORCID=

en-aut-name=YanoShuya
en-aut-sei=Yano
en-aut-mei=Shuya
kn-aut-name=矢野修也
kn-aut-sei=矢野
kn-aut-mei=修也
aut-affil-num=6
ORCID=

en-aut-name=TazawaHiroshi
en-aut-sei=Tazawa
en-aut-mei=Hiroshi
kn-aut-name=田澤大
kn-aut-sei=田澤
kn-aut-mei=大
aut-affil-num=7
ORCID=

en-aut-name=UnoFutoshi
en-aut-sei=Uno
en-aut-mei=Futoshi
kn-aut-name=宇野太
kn-aut-sei=宇野
kn-aut-mei=太
aut-affil-num=8
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=香川俊輔
kn-aut-sei=香川
kn-aut-mei=俊輔
aut-affil-num=9
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=10
ORCID=

en-aut-name=UrataYasuo
en-aut-sei=Urata
en-aut-mei=Yasuo
kn-aut-name=浦田泰生
kn-aut-sei=浦田
kn-aut-mei=泰生
aut-affil-num=11
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=2
en-affil=
kn-affil=オンコリスバイオファーマ

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=11
en-affil=
kn-affil=オンコリスバイオファーマ

affil-num=12
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
en-keyword=telomerase
kn-keyword=telomerase
en-keyword=oncolytic adenovirus
kn-keyword=oncolytic adenovirus
en-keyword=lymph node metastasis
kn-keyword=lymph node metastasis
en-keyword=orthotopic colorectal cancer model
kn-keyword=orthotopic colorectal cancer model
en-keyword=<i>Alu</i> sequence
kn-keyword=<i>Alu</i> sequence
END

start-ver=1.4
cd-journal=joma
no-vol=123
cd-vols=
no-issue=1
article-no=
start-page=39
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Investigation of laparoscopic therapy in 56 cases of duodenal ulcer perforation
kn-title=成人先天性胆道拡張症の6例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report six patients with adult congenital biliary dilatation treated by surgery. Of the six cases, five were female and the patients' age at diagnosis ranged from 19 to 51 years old. By Todani's classification for bile duct dilatation, three were categorized as Ⅰa, one as Ⅰb, and two as Ⅳa. All six cases had anomalous arrangement of the pancreatobiliary duct. Resection of the cystic portion and hepaticojejunostomy (Roux-Y) were performed in all. After surgery, one patient classified as Ⅰa and one as Ⅳa had complications of cholangitis and intrahepatic stones. We removed the stones by the percutaneous transhepatic route with dilatation of the stenotic anastomosis, but cholangitis recurred in the Ⅳa patient. Although surgical resection of the cystic portion and reconstruction of biliary tract is considered to be a standard treatment for adult congenital biliary dilatation, this Ⅳa case had complications after surgical treatment. Thus short-term follow-up is necessary to prevent or diagnose stenotic anastomosis following the operation.
en-copyright=
kn-copyright=

en-aut-name=TakashimaHirotoshi
en-aut-sei=Takashima
en-aut-mei=Hirotoshi
kn-aut-name=高嶌寛年
kn-aut-sei=高嶌
kn-aut-mei=寛年
aut-affil-num=1
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=佐々木明
kn-aut-sei=佐々木
kn-aut-mei=明
aut-affil-num=2
ORCID=

en-aut-name=SasakiKaoru
en-aut-sei=Sasaki
en-aut-mei=Kaoru
kn-aut-name=佐々木薫
kn-aut-sei=佐々木
kn-aut-mei=薫
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=医療法人社団曙会　佐々木外科病院

affil-num=2
en-affil=
kn-affil=医療法人社団曙会　佐々木外科病院

affil-num=3
en-affil=
kn-affil=医療法人社団曙会　佐々木外科病院
en-keyword=先天性胆道拡張症 (congenital biliary dilatation)
kn-keyword=先天性胆道拡張症 (congenital biliary dilatation)
en-keyword=膵胆管合流異常 (anomalous arrangement of pancreaticobiliary ducts)
kn-keyword=膵胆管合流異常 (anomalous arrangement of pancreaticobiliary ducts)
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=3
article-no=
start-page=203
end-page=208
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20101201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of novel detecting systems and therapies for micro cancer using replication-competent oncolytic adenovirus
kn-title=制限増殖型アデノウイルス製剤を用いた新たな微小がん病変の検出法の開発と治療への応用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KojimaToru
en-aut-sei=Kojima
en-aut-mei=Toru
kn-aut-name=児島亨
kn-aut-sei=児島
kn-aut-mei=亨
aut-affil-num=1
ORCID=

en-aut-name=HashimotoYuuri
en-aut-sei=Hashimoto
en-aut-mei=Yuuri
kn-aut-name=橋本悠里
kn-aut-sei=橋本
kn-aut-mei=悠里
aut-affil-num=2
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=香川俊輔
kn-aut-sei=香川
kn-aut-mei=俊輔
aut-affil-num=3
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=4
ORCID=

en-aut-name=UrataYasuo
en-aut-sei=Urata
en-aut-mei=Yasuo
kn-aut-name=浦田泰生
kn-aut-sei=浦田
kn-aut-mei=泰生
aut-affil-num=5
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=5
en-affil=
kn-affil=オンコリスバイオファーマ

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学
en-keyword=telomerase
kn-keyword=telomerase
en-keyword=oncolytic adenovirus
kn-keyword=oncolytic adenovirus
en-keyword=GFP
kn-keyword=GFP
en-keyword=micrometastasis
kn-keyword=micrometastasis
en-keyword=circulating tumor cell
kn-keyword=circulating tumor cell
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=2
article-no=
start-page=107
end-page=112
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Analysis of fecal DNA methylation to detect gastrointestinal neoplasia
kn-title=便中メチル化DNA検出による消化器がんスクリーニング：消化器がんを非侵襲的にスクリーニングすることは可能か？
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagasakaTakeshi
en-aut-sei=Nagasaka
en-aut-mei=Takeshi
kn-aut-name=永坂岳司
kn-aut-sei=永坂
kn-aut-mei=岳司
aut-affil-num=1
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=2
ORCID=

en-aut-name=SunDong-Sheng
en-aut-sei=Sun
en-aut-mei=Dong-Sheng
kn-aut-name=孫冬生
kn-aut-sei=孫
kn-aut-mei=冬生
aut-affil-num=3
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=4
ORCID=

en-aut-name=MastubaraNagahide
en-aut-sei=Mastubara
en-aut-mei=Nagahide
kn-aut-name=松原長秀
kn-aut-sei=松原
kn-aut-mei=長秀
aut-affil-num=5
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=6
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬総合研究科　消化器・腫瘍外科学

affil-num=2
en-affil=
kn-affil=鳥取市立病院

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬総合研究科　消化器・腫瘍外科学

affil-num=4
en-affil=
kn-affil=川崎医科大学附属病院　外科

affil-num=5
en-affil=
kn-affil=兵庫医科大学　外科

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬総合研究科　消化器・腫瘍外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬総合研究科　消化器・腫瘍外科学
en-keyword=methylation
kn-keyword=methylation
en-keyword=stool
kn-keyword=stool
en-keyword=colorectal cancer
kn-keyword=colorectal cancer
en-keyword=gastric cancer
kn-keyword=gastric cancer
en-keyword=screening
kn-keyword=screening
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=
article-no=
start-page=12
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=199809
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=癌の遺伝子治療
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=癌抑制遺伝子p53の突然変異や欠損による機能的異常は､多くのヒト癌で普遍的かつ高頻度に認められている｡p53タンパク質の機能の一つとしては､細胞増殖に関するいろいろな遺伝子の発現制御を介した細胞周期の調節が考えられているが､その他に最近アポトーシスの誘導分子としても注目を浴びてきている｡正常型p53遺伝子を有する胃癌､大腸癌では､術前化学療法や放射線療法で癌細胞のアポトーシスが誘導されたが､変異型p53を発現する腫瘍
ではアポトーシスに陥った細胞はほとんど認められなかった｡ヌードマウスの皮下に移植したp53遺伝子に異常を持つヒト肺癌腫瘍にリコンビナント･アデノウイルスベクターを用いて正常型p53遺伝子を導入すると､抗癌剤に対する感受性が劇的に増強し､シスプラチンの腹腔内投与により腫瘍内にアポトーシスによる広範囲な組織破壊が認められた｡この正常型p53発現アデノウイルスベクターとDNA障害性抗癌剤を併用した遺伝子治療は､臨床的にヒト悪性腫癌に応用可能と考えられる｡
en-copyright=
kn-copyright=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=1
article-no=
start-page=81
end-page=82
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=鳥取市立病院
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=鳥取市立病院
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=25
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits an anticancer effect in esophageal adenocarcinoma in vitro and in vivo
kn-title=Focal adhesion kinase (FAK) と Insulin-like growth factor-I receptor (IGF-IR) に対するデュアルチロシンキナーゼ阻害剤の食道腺癌における抗腫瘍効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WatanabeNobuyuki
en-aut-sei=Watanabe
en-aut-mei=Nobuyuki
kn-aut-name=渡辺信之
kn-aut-sei=渡辺
kn-aut-mei=信之
aut-affil-num=1
ORCID=

en-aut-name=TakaokaMunenori
en-aut-sei=Takaoka
en-aut-mei=Munenori
kn-aut-name=髙岡宗徳
kn-aut-sei=髙岡
kn-aut-mei=宗徳
aut-affil-num=2
ORCID=

en-aut-name=SakuramaKazufumi
en-aut-sei=Sakurama
en-aut-mei=Kazufumi
kn-aut-name=櫻間一史
kn-aut-sei=櫻間
kn-aut-mei=一史
aut-affil-num=3
ORCID=

en-aut-name=TomonoYasuko
en-aut-sei=Tomono
en-aut-mei=Yasuko
kn-aut-name=友野靖子
kn-aut-sei=友野
kn-aut-mei=靖子
aut-affil-num=4
ORCID=

en-aut-name=HatakeyamaShinji
en-aut-sei=Hatakeyama
en-aut-mei=Shinji
kn-aut-name=畠山慎二
kn-aut-sei=畠山
kn-aut-mei=慎二
aut-affil-num=5
ORCID=

en-aut-name=OhmoriOsamu
en-aut-sei=Ohmori
en-aut-mei=Osamu
kn-aut-name=大森修
kn-aut-sei=大森
kn-aut-mei=修
aut-affil-num=6
ORCID=

en-aut-name=MotokiTakayuki
en-aut-sei=Motoki
en-aut-mei=Takayuki
kn-aut-name=元木崇之
kn-aut-sei=元木
kn-aut-mei=崇之
aut-affil-num=7
ORCID=

en-aut-name=ShirakawaYasuhiro
en-aut-sei=Shirakawa
en-aut-mei=Yasuhiro
kn-aut-name=白川靖博
kn-aut-sei=白川
kn-aut-mei=靖博
aut-affil-num=8
ORCID=

en-aut-name=YamatsujiTomoki
en-aut-sei=Yamatsuji
en-aut-mei=Tomoki
kn-aut-name=山辻知樹
kn-aut-sei=山辻
kn-aut-mei=知樹
aut-affil-num=9
ORCID=

en-aut-name=HaisaMinoru
en-aut-sei=Haisa
en-aut-mei=Minoru
kn-aut-name=羽井佐実
kn-aut-sei=羽井佐
kn-aut-mei=実
aut-affil-num=10
ORCID=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=松岡順治
kn-aut-sei=松岡
kn-aut-mei=順治
aut-affil-num=11
ORCID=

en-aut-name=BeerDavid G.
en-aut-sei=Beer
en-aut-mei=David G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=長塚仁
kn-aut-sei=長塚
kn-aut-mei=仁
aut-affil-num=13
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=14
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=15
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=4
en-affil=
kn-affil=重井医学研究所

affil-num=5
en-affil=
kn-affil=ノバルティスファーマ　筑波研究所

affil-num=6
en-affil=
kn-affil=ノバルティスファーマ　筑波研究所

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=10
en-affil=
kn-affil=岡山市立市民病院　外科

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=12
en-affil=
kn-affil=ミシガン大学　胸部外科

affil-num=13
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　口腔病理学

affil-num=14
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=15
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学
en-keyword=focal adhesion kinase (FAK)
kn-keyword=focal adhesion kinase (FAK)
en-keyword=バレット食道癌
kn-keyword=バレット食道癌
en-keyword=FAK阻害剤
kn-keyword=FAK阻害剤
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=3-4
article-no=
start-page=369
end-page=377
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19780430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of tumor-BCG mixture to the cellular cytotoxicity against tumor allograft
kn-title=同種腫瘍移植に於けるCellular CytotoXiCityに及ぼすBCG―腫瘍混合接種の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of tumor-BCG mixture to the cellular cytotoxicity of the regional lymph node and the spleen were observed in BALB/c mice received allogeneic tumor cells. This tumor cells, when grafted subcutaneously, were normally enhanced in 40% of BALB/c mice and 100% of A/St mice, but failed to grow when injected as a mixture with tumor and BCG. By injection of tumor-BCG mixture, the development and decline of the cytotoxicity((51)Cr release assay) to the tumor cells was accelerated, but the magnitude of the peak activity was diminished. Possible mechanisms by which the decreased activity induced of complete tumor suppression were examined. The result showed that immunized lymphocytes with non-immune macrophages exhibited a significatly increased cytotoxicity as compared with immunized lymphocytes in the abscence of macrophages.
en-copyright=
kn-copyright=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=3-4
article-no=
start-page=355
end-page=367
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19780430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immune response to tumor allograft: comparison of two in vitro assays of cell mediated cytotoxicity
kn-title=同種腫瘍移植に対するcellular cytotoxicity 二つのin vitro assayの比較
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A microcytotoxicity assay (MCA) and a (51)Cr release cytotoxicity assay (CRA) for cell mediated immunity to the allogeneic tumor were done in parallel with same reagents used for both assays. Therefore, CRA was modified in which monolayer culture cells were used as target cells and MCA was devised in which the adherent surviving target cells after the interaction with effector cells were assessed by (51)Cr uptake (so called (51)Cr post-labeling assay...CPLA). Under standard conditions, CPLA detected a significant activity of weakly sensitized lymphocytes which was not detected by CRA. Reactivity of lymph node cells after the tumor transplantation was tested simultaneously in CRA, CPLA and the macrophage migration inhibition test (MIT). The data showed that CPLA detected immune reactivity for longer period than CRA, and as long as MIT. The lytic activity of lymph node cells 8 days after immunization was monitored by a long term CRA (40-hours' incubation). The cytotoxicity value for late 20 hr was remarkably higher than for early 20 hr. This in vitro activation of sensitized lymphocytes indicated a peak at 8 days and then declined, dissappeared at 14 days. When both assays were done under same condition, CPLA detected a moderate activity which was not detected by CRA. This result means that CPLA could detect immune responses which inhibit tumor cell growth without killing them. Both assays detected primarily a T lymphocyte-mediated activity. The CPLA also detected a weak non T-cell activity in anti-θ plus complement-treated alloimmune lymph node.
en-copyright=
kn-copyright=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=3
article-no=
start-page=157
end-page=162
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of novel transactivation systems for cancer therapy
kn-title=特異的プロモータを用いた目的遺伝子発現システムの開発と癌治療への応用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FukazawaTakuya
en-aut-sei=Fukazawa
en-aut-mei=Takuya
kn-aut-name=深澤拓也
kn-aut-sei=深澤
kn-aut-mei=拓也
aut-affil-num=1
ORCID=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=松岡順治
kn-aut-sei=松岡
kn-aut-mei=順治
aut-affil-num=2
ORCID=

en-aut-name=YamatsujiTomoki
en-aut-sei=Yamatsuji
en-aut-mei=Tomoki
kn-aut-name=山辻知樹
kn-aut-sei=山辻
kn-aut-mei=知樹
aut-affil-num=3
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=4
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学
en-keyword=組織特異的転写因子
kn-keyword=組織特異的転写因子
en-keyword=プロモータ
kn-keyword=プロモータ
en-keyword=遺伝子治療
kn-keyword=遺伝子治療
en-keyword=ウイルス療法
kn-keyword=ウイルス療法
en-keyword=分子標的治療
kn-keyword=分子標的治療
END

start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=45
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evidence-based clinical practice guidelines for hepatocellular carcinoma
kn-title=肝癌診療ガイドライン
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KobayashiYoshiyuki
en-aut-sei=Kobayashi
en-aut-mei=Yoshiyuki
kn-aut-name=小林功幸
kn-aut-sei=小林
kn-aut-mei=功幸
aut-affil-num=1
ORCID=

en-aut-name=NakamuraShinichiro
en-aut-sei=Nakamura
en-aut-mei=Shinichiro
kn-aut-name=中村進一郎
kn-aut-sei=中村
kn-aut-mei=進一郎
aut-affil-num=2
ORCID=

en-aut-name=OhnishiHideki
en-aut-sei=Ohnishi
en-aut-mei=Hideki
kn-aut-name=大西秀樹
kn-aut-sei=大西
kn-aut-mei=秀樹
aut-affil-num=3
ORCID=

en-aut-name=ToshimoriJunichi
en-aut-sei=Toshimori
en-aut-mei=Junichi
kn-aut-name=歳森淳一
kn-aut-sei=歳森
kn-aut-mei=淳一
aut-affil-num=4
ORCID=

en-aut-name=KuwakiKenji
en-aut-sei=Kuwaki
en-aut-mei=Kenji
kn-aut-name=桑木健志
kn-aut-sei=桑木
kn-aut-mei=健志
aut-affil-num=5
ORCID=

en-aut-name=HagiharaHiroaki
en-aut-sei=Hagihara
en-aut-mei=Hiroaki
kn-aut-name=萩原宏明
kn-aut-sei=萩原
kn-aut-mei=宏明
aut-affil-num=6
ORCID=

en-aut-name=MiyakeYasuhiro
en-aut-sei=Miyake
en-aut-mei=Yasuhiro
kn-aut-name=三宅康広
kn-aut-sei=三宅
kn-aut-mei=康広
aut-affil-num=7
ORCID=

en-aut-name=ShirahaHidenori
en-aut-sei=Shiraha
en-aut-mei=Hidenori
kn-aut-name=白羽英則
kn-aut-sei=白羽
kn-aut-mei=英則
aut-affil-num=8
ORCID=

en-aut-name=NousoKazuhiro
en-aut-sei=Nouso
en-aut-mei=Kazuhiro
kn-aut-name=能祖一裕
kn-aut-sei=能祖
kn-aut-mei=一裕
aut-affil-num=9
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=10
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=11
ORCID=

en-aut-name=YamamotoKazuhide
en-aut-sei=Yamamoto
en-aut-mei=Kazuhide
kn-aut-name=山本和秀
kn-aut-sei=山本
kn-aut-mei=和秀
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=12
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学
END

start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=33
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Mid-West Japan Cancer Professional Education Consortium
kn-title=中国四国広域プロ養成プログラム ―チーム医療を担うがん専門医療人の育成―www.chushiganpro.jp
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=松岡順治
kn-aut-sei=松岡
kn-aut-mei=順治
aut-affil-num=1
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=2
ORCID=

en-aut-name=TabataMasahiro
en-aut-sei=Tabata
en-aut-mei=Masahiro
kn-aut-name=田端雅弘
kn-aut-sei=田端
kn-aut-mei=雅弘
aut-affil-num=3
ORCID=

en-aut-name=ShirakawaYasuhiro
en-aut-sei=Shirakawa
en-aut-mei=Yasuhiro
kn-aut-name=白川靖博
kn-aut-sei=白川
kn-aut-mei=靖博
aut-affil-num=4
ORCID=

en-aut-name=HottaKatsuyuki
en-aut-sei=Hotta
en-aut-mei=Katsuyuki
kn-aut-name=堀田勝幸
kn-aut-sei=堀田
kn-aut-mei=勝幸
aut-affil-num=5
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=谷本光音
kn-aut-sei=谷本
kn-aut-mei=光音
aut-affil-num=6
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=3
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　腫瘍センター

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学
en-keyword=がんプロ
kn-keyword=がんプロ
en-keyword=チーム医療
kn-keyword=チーム医療
en-keyword=大学院
kn-keyword=大学院
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=3-4
article-no=
start-page=259
end-page=266
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental and clinical studies on interferon and its inducers Part 2. β-carboxyethylgermanium sesquioxide (Ge-132) in the management of acute nonlymphocytic leukemia patients at remission phase
kn-title=インターフェロン並びにインターフェロン誘発剤に関する基礎的・臨床的研究　第2編　急性非リンパ性白血病寛解期における β-Carboxyethylgermanium sesquioxide (Ge-132) の臨床効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The clinieal of Ge-132 in the management of acute nonlymphocytic leukemia (ANLL) patients at remission phase were studied. Twenty-two ANLL patients with complete remission were randomized into Groups A and B. Patients in Group A were treated with the combianation with Ge-132 (2,250mg/day ; p. o daily) and intermittent-alternating chemotherapy 〔daunorubicin, vincristine, cytosine arabinoside and prednisolone (DVCP)/aclarubicin vincristine cytosine arabinoside and prednisolone (AVCP)〕and patients in Groyp B were treated with intermittent-alter nating chemotherapy (DVCP/AVCP) alone. Evaluable patients were 7 in Group A and 10 in Group B. Remission duration and survival time were not significantly different between Groups A and B. (median remission duration ; 5.7 month in Group A vs 8.1 month in Group B/median surival time ; 23.9month in Group A vs 18.3month in Group B) The rates of second remission in relapsed cases were not significantly different between Groups A and B.〔2 of 7,(28.6%) in Group A vs 3 of 10,(30.0%) in B〕Ge-132 did not accelerate the recovery from myelosuppression after intensification with the DVCP regimen. The incidence of liver damage and levels of serum GOT and GPT tended to be lower in Group A than in Group B. In this clinical study the incidence of liver damage tended to be lowere in patients treated with Ge-132. The liver damage which often develops during intensificantion chemotherapy, not only limits the chemotherapy but also causes adverse effects on the quality of life of the patient. In part 1 of this series, Ge-132 was reported to activate the neutrophil chemiluminescence. Ge-132 seems to be useful in the management of ANLL patients not only by the enhancement of the host defense system but also by the prevenation of liver damage.
en-copyright=
kn-copyright=

en-aut-name=FukumotoMitsuhiro
en-aut-sei=Fukumoto
en-aut-mei=Mitsuhiro
kn-aut-name=福本光宏
kn-aut-sei=福本
kn-aut-mei=光宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Ge-132
kn-keyword=Ge-132
en-keyword=Biological response modifier
kn-keyword=Biological response modifier
en-keyword=Acute nonlymphocytic leukemia
kn-keyword=Acute nonlymphocytic leukemia
en-keyword=Immunotherapy
kn-keyword=Immunotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=3-4
article-no=
start-page=241
end-page=246
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effect of cyclosporin A on liver regeneration
kn-title=肝再生に及ぼす Cyclosporin A の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=When lymphokine activiated killer cells (LAK cell) induced by IL-2 are infused into the same strain C(3)H mice following 70% partial hepatectomy, they display an action to suppress liver regeneration. Therefore, when Cyclosporin A (CsA) which inhibits IL-2 production was administerd to mice following partial hepatectomy, we studied as our indicator the labeling index of hepatic parenchyma cells using Brdu. Our findings showed that proliferation of live cells at 36 hours following partial hepatectomy was promoted by CsA, and the streongest promotion occuring at a dose of 5mg/kg. Before anf after hepatectomy when CsA was administered at 10mg/kg for 3 dadys, a further strong proliferation increasing effect was observed, and under these conditions at 48 and 60 hours after hepatectomy a significant increase in liver weight was observed. Give the above results, CsA  it thought to have a promoting effect in liver regeneration following hepatectomy.
en-copyright=
kn-copyright=

en-aut-name=YamamotoHiroshi
en-aut-sei=Yamamoto
en-aut-mei=Hiroshi
kn-aut-name=山本浩史
kn-aut-sei=山本
kn-aut-mei=浩史
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=Cyclosporin A
kn-keyword=Cyclosporin A
en-keyword=肝再生
kn-keyword=肝再生
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=75
end-page=82
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of immunosuppressive substance against the potency of natural human tumor necrosis factor as biological response modifier
kn-title=Biological response modifier としての Tumor necrosis fator の効果に対する Immunosuppressive substance の作用の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=TNF is a cytokine with the activity of a BRM (biological response modifier). TNF-α and TNF-β enhanced NK activity of peripheral blood mononucleocytes of a normal donor, but not in a cancer patient. ISS, a glocoprotein extracted from the ascitic fluid of a colon cancer patient with immunosuppressive properties, ia also detected in large quantities in the serum of cancer patients. NK activity of a normal donor which was in an immunosuppressive state by the administration of ISS was not affected by treatment of TNF-α or TNF-β, but the suppressed NK activity was improved by the combination of TNF with IFN-α or IFN-γ. On the other hand, NK activity of a cancer patient treated with anti-IS antiserum which was obtained from serum of rabbit immunized by ISS was enhanced by both TNFs. These findings suggest that ISS suppresses the effect of TNFs on NK activity. Furthermore, the effect of TNF as a BRM is inhibited in cancer patients due to the high dose of ISS in the serum, and that the combination of TNF with other cytokines, such as IFN, is more effective than the single use of TNF, clinically.
en-copyright=
kn-copyright=

en-aut-name=YasuiYoshimasa
en-aut-sei=Yasui
en-aut-mei=Yoshimasa
kn-aut-name=安井義政
kn-aut-sei=安井
kn-aut-mei=義政
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=biological response modifier (BRM)
kn-keyword=biological response modifier (BRM)
en-keyword=tumor necrosis fator (TNF)
kn-keyword=tumor necrosis fator (TNF)
en-keyword=immunosuppressive substance (IS 物質)
kn-keyword=immunosuppressive substance (IS 物質)
en-keyword=natural killer (NK) 活性
kn-keyword=natural killer (NK) 活性
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=21
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Antitumor effect of interferon-α, γ and/or tumor necrosis factor-α against human colon cancer line (LoVo) transplanted into nude mice
kn-title=ヌードマウス可移植性ヒト大腸癌細胞株 LoVoに対する interferon-α,-γ, tumor necrosis factor-α の抗腫瘍効果の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated the in vivo antitumor effect of recombinant human interferon-α,γ (IFN-α,γ) and/or recombinant human tumor necrosis factor-α (TNF-α) against human colon cancer cells (LoVo) transplanted into nude mice. LoVo cells were very sensitive to IFN-γ and slightly sensitive to IFN-α and resistant to TNF-α in vitro by dye uptake method. Intravenous administration of IFN-γ significantly inhibited tumor growth transplanted subcutaneously into nude mice, but IFN-α and/or TNF-α did not show any antitumor effect. Labeling index on stanining with bromodeoxyuridune and mitotic index of LoVo cells treated with IFN-α,γ or TNF-α differed slightly from those of the control group. We previously reported that the synergistic antitumor effects on the three cell lines could be examined by the combined use of IFN-α and TNF-α and the mechanism of the synergism was arrested in the S phase of cell cycle of target cells. However in the cese of LoVo cells, the combined use of IFN-α and TNF-α was not effective and did not arrest the cells in tha S phase of cell cycle. Therefore, arrest in the S phase was suspected to be responsible from the synergistic antitumor activity of IFN-α and TNF-α on the sensitive targets.
en-copyright=
kn-copyright=

en-aut-name=KataokaKazuhiko
en-aut-sei=Kataoka
en-aut-mei=Kazuhiko
kn-aut-name=片岡和彦
kn-aut-sei=片岡
kn-aut-mei=和彦
aut-affil-num=1
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=2
ORCID=

en-aut-name=MuroMasahiko
en-aut-sei=Muro
en-aut-mei=Masahiko
kn-aut-name=室雅彦
kn-aut-sei=室
kn-aut-mei=雅彦
aut-affil-num=3
ORCID=

en-aut-name=KojimaKazushi
en-aut-sei=Kojima
en-aut-mei=Kazushi
kn-aut-name=小島一志
kn-aut-sei=小島
kn-aut-mei=一志
aut-affil-num=4
ORCID=

en-aut-name=HorikiSadayuki
en-aut-sei=Horiki
en-aut-mei=Sadayuki
kn-aut-name=堀木貞幸
kn-aut-sei=堀木
kn-aut-mei=貞幸
aut-affil-num=5
ORCID=

en-aut-name=HizutaAkio
en-aut-sei=Hizuta
en-aut-mei=Akio
kn-aut-name=日伝晶夫
kn-aut-sei=日伝
kn-aut-mei=晶夫
aut-affil-num=6
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=7
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=nude mouse
kn-keyword=nude mouse
en-keyword=human colon cancer
kn-keyword=human colon cancer
en-keyword=interferon
kn-keyword=interferon
en-keyword=tumor necrosis factor
kn-keyword=tumor necrosis factor
en-keyword=cell cycle
kn-keyword=cell cycle
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=3-4
article-no=
start-page=299
end-page=304
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=1994
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of broncholithiasis complicating hemoptysis
kn-title=喀血を主訴に来院した気管支結石の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 62-year-old male was admitted because of hemoptysis. The chest X-ray showed an infiltrative shadow in the right upper lung field. Tomograms and CT scans also showed an infiltrative shadow and small calcifications in the same field. Examination by bronchoscopy revealed bronchial bleeding from the depth of the right B1b. Although the detailed view was unclear due to bleeding, we did not find any growth or any mucosal abnormality. We examined only the bronchial washing cytology. The result was Papanicolaou class Ⅱ. However, we could not rule out malignancy, so we decided to perform a right upper lobectomy. A bron-cholith was seen in the B1b and a hematoma was also seen on its periphery. The stone components were calcium carbonate (74%) and calcium phosphate (26%), suggesting that the stone was caused by mucus retention.
en-copyright=
kn-copyright=

en-aut-name=IshiiYasunori
en-aut-sei=Ishii
en-aut-mei=Yasunori
kn-aut-name=石井泰則
kn-aut-sei=石井
kn-aut-mei=泰則
aut-affil-num=1
ORCID=

en-aut-name=InoueFumiyuki
en-aut-sei=Inoue
en-aut-mei=Fumiyuki
kn-aut-name=井上文之
kn-aut-sei=井上
kn-aut-mei=文之
aut-affil-num=2
ORCID=

en-aut-name=ShinRyuhan
en-aut-sei=Shin
en-aut-mei=Ryuhan
kn-aut-name=慎隆範
kn-aut-sei=慎
kn-aut-mei=隆範
aut-affil-num=3
ORCID=

en-aut-name=IshizukaShinji
en-aut-sei=Ishizuka
en-aut-mei=Shinji
kn-aut-name=石塚真示
kn-aut-sei=石塚
kn-aut-mei=真示
aut-affil-num=4
ORCID=

en-aut-name=FunakiNaoto
en-aut-sei=Funaki
en-aut-mei=Naoto
kn-aut-name=舟木直人
kn-aut-sei=舟木
kn-aut-mei=直人
aut-affil-num=5
ORCID=

en-aut-name=MuramatsuTomoyoshi
en-aut-sei=Muramatsu
en-aut-mei=Tomoyoshi
kn-aut-name=村松友義
kn-aut-sei=村松
kn-aut-mei=友義
aut-affil-num=6
ORCID=

en-aut-name=KamikawaYasuaki
en-aut-sei=Kamikawa
en-aut-mei=Yasuaki
kn-aut-name=上川康明
kn-aut-sei=上川
kn-aut-mei=康明
aut-affil-num=7
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=8
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=9
ORCID=

en-aut-name=OdaKoji
en-aut-sei=Oda
en-aut-mei=Koji
kn-aut-name=小田晧二
kn-aut-sei=小田
kn-aut-mei=晧二
aut-affil-num=10
ORCID=

en-aut-name=SeoKenji
en-aut-sei=Seo
en-aut-mei=Kenji
kn-aut-name=瀬尾憲治
kn-aut-sei=瀬尾
kn-aut-mei=憲治
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=10
en-affil=
kn-affil=小田病院外科

affil-num=11
en-affil=
kn-affil=健照会セオ病院
en-keyword=気管支結石
kn-keyword=気管支結石
en-keyword=喀血
kn-keyword=喀血
en-keyword=Broncholithiasis
kn-keyword=Broncholithiasis
en-keyword=Hemoptysis
kn-keyword=Hemoptysis
END

start-ver=1.4
cd-journal=joma
no-vol=120
cd-vols=
no-issue=3
article-no=
start-page=321
end-page=327
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20081201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=XVI Current status and perspectives of gene therapy for cancer
kn-title=XVI がんに対する遺伝子治療の現況と展望
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=1
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　遺伝子・細胞治療センター

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学
en-keyword=遺伝子治療
kn-keyword=遺伝子治療
en-keyword=アデノウイルスベクター
kn-keyword=アデノウイルスベクター
en-keyword=p53
kn-keyword=p53
en-keyword=テロメラーゼ
kn-keyword=テロメラーゼ
END

start-ver=1.4
cd-journal=joma
no-vol=120
cd-vols=
no-issue=3
article-no=
start-page=259
end-page=264
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20081201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Virus-mediated oncolysis induces danger signals and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation
kn-title=腫瘍融解ウイルスによる細胞死であるオンコライシスは細胞内に danger signal を発生させ，プロテアソームアクチベーター(PA28)発現を増強することで細胞障害性Ｔリンパ球による免疫応答を活性化する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=EndoYoshikatsu
en-aut-sei=Endo
en-aut-mei=Yoshikatsu
kn-aut-name=遠藤芳克
kn-aut-sei=遠藤
kn-aut-mei=芳克
aut-affil-num=1
ORCID=

en-aut-name=SakaiRyo
en-aut-sei=Sakai
en-aut-mei=Ryo
kn-aut-name=酒井亮
kn-aut-sei=酒井
kn-aut-mei=亮
aut-affil-num=2
ORCID=

en-aut-name=OuchiMasaaki
en-aut-sei=Ouchi
en-aut-mei=Masaaki
kn-aut-name=大内正明
kn-aut-sei=大内
kn-aut-mei=正明
aut-affil-num=3
ORCID=

en-aut-name=OnimatsuHideki
en-aut-sei=Onimatsu
en-aut-mei=Hideki
kn-aut-name=鬼松秀樹
kn-aut-sei=鬼松
kn-aut-mei=秀樹
aut-affil-num=4
ORCID=

en-aut-name=HiokiMasayoshi
en-aut-sei=Hioki
en-aut-mei=Masayoshi
kn-aut-name=日置勝義
kn-aut-sei=日置
kn-aut-mei=勝義
aut-affil-num=5
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=香川俊輔
kn-aut-sei=香川
kn-aut-mei=俊輔
aut-affil-num=6
ORCID=

en-aut-name=UnoFutoshi
en-aut-sei=Uno
en-aut-mei=Futoshi
kn-aut-name=宇野太
kn-aut-sei=宇野
kn-aut-mei=太
aut-affil-num=7
ORCID=

en-aut-name=WatanabeYuichi
en-aut-sei=Watanabe
en-aut-mei=Yuichi
kn-aut-name=渡邉雄一
kn-aut-sei=渡邉
kn-aut-mei=雄一
aut-affil-num=8
ORCID=

en-aut-name=UrataYasuo
en-aut-sei=Urata
en-aut-mei=Yasuo
kn-aut-name=浦田泰生
kn-aut-sei=浦田
kn-aut-mei=泰生
aut-affil-num=9
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=10
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学
en-keyword=adenovirus
kn-keyword=adenovirus
en-keyword=telomerase
kn-keyword=telomerase
en-keyword=dendritic cell
kn-keyword=dendritic cell
en-keyword=uric acid
kn-keyword=uric acid
en-keyword=danger signal
kn-keyword=danger signal
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=11-12
article-no=
start-page=1125
end-page=1142
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Possible anti-tumor effects of drug-induced splenectomy with cyclophosphamide and indomethacin, and surgical splenectomy in combination with immunochemotherapy in tumor-bearing mice and gastric cancer patients
kn-title=担癌マウスならびに胃癌患者における Cyclophosphamide と Indomethacin による薬物学的摘脾効果の可能性，および外科的摘脾と免疫化学療法併用に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using tumor-bearing C(3)H/He mice, in which syngeneic MH-134 tumor cells were transplanted into the back subcutaneously, the possibility of drug-induced splenectomy using cyclophosphamide (CY) and indomethacin (INDO), the timing of chemo- and immuno-therapy, and the usefulness of the combination of surgical splenectomy with immunotherapy were investigated. In patients with gastric cancer, the significance of splenectomy and its combination with immunochemotherapy was also studied.
The administration of CY in mice on day 3 after tumor transplantation in the initial stage of the tumor prolonged the survival time, while INDO under the same condition shortened it only when administered on day 3 after transplantation. The administration of an immunopotentiator, OK-432, prior to CY administration shortened the survival time, compared with that of single administration of CY, whereas the OK-432 administration on day 2 after the administration of CY prolonged the survival time. In the immunochemotherapy in which CY was administered on day 7 after transplantation of tumor and OK-432 was given every two days after additional 2 days, the anti-tumor effect of drug-induced splenectomy was not observed as judged from the tumor proliferating curve, but the splenectomy on day 3 after tumor transplantation, in the initial stage of the tumor, prolonged tne survival time. Similar results were observed, when INDO was used instead of CY. The concomitant splenectomy in the initial stage of gastric cancer resulted in a more effective prolongation of survival time. In the cases with adjuvant immunochemotherapy, preservation of the spleen in advanced cancer and splenectomy in the terminal stage of cancer were found to be preferable for effective prolongation of the survival time.
en-copyright=
kn-copyright=

en-aut-name=YuiJiro
en-aut-sei=Yui
en-aut-mei=Jiro
kn-aut-name=由井治郎
kn-aut-sei=由井
kn-aut-mei=治郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=薬物学的摘脾
kn-keyword=薬物学的摘脾
en-keyword=cyclophosphamide
kn-keyword=cyclophosphamide
en-keyword=indomethacin
kn-keyword=indomethacin
en-keyword=摘脾と免疫療法
kn-keyword=摘脾と免疫療法
en-keyword=摘脾と免疫化学療法
kn-keyword=摘脾と免疫化学療法
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=1-2
article-no=
start-page=33
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Recurrent breast cancer
kn-title=乳癌再発症例の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To study the relationship between recurrence factors, recurrence sites, prognoses and disease free intervals (DFI), 63 patients with recurrent breast cancer after radical surgery were divided into 3 groups by disease free intervals of less than 2 years (A group, 25 cases), 2 to 5 years (B group, 23 cases) and more than 5 years (C group, 15 cases). The average age at surgery was higher, and the diameter of the tumor decreased as the DFI increased. The rate of lymph node metastasis was higher in group A. The proportion of cases in stage b was small in group C. Common sites of recurrence were soft tissue in group A and and bone in group C. The survival rate was significantly higher in group C compared to those in groups A and B (p<0.05). It is necessary to follow patients treated for breast cancer for a long period postoperatively, and if the recurrence develop, multidisciplinary therapy to prolong survival should consider these prognostic factors.
en-copyright=
kn-copyright=

en-aut-name=ShiikiShigeo
en-aut-sei=Shiiki
en-aut-mei=Shigeo
kn-aut-name=椎木滋雄
kn-aut-sei=椎木
kn-aut-mei=滋雄
aut-affil-num=1
ORCID=

en-aut-name=InoueFumiyuki
en-aut-sei=Inoue
en-aut-mei=Fumiyuki
kn-aut-name=井上文之
kn-aut-sei=井上
kn-aut-mei=文之
aut-affil-num=2
ORCID=

en-aut-name=TanakaShinichiro
en-aut-sei=Tanaka
en-aut-mei=Shinichiro
kn-aut-name=田中信一郎
kn-aut-sei=田中
kn-aut-mei=信一郎
aut-affil-num=3
ORCID=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=松岡順治
kn-aut-sei=松岡
kn-aut-mei=順治
aut-affil-num=4
ORCID=

en-aut-name=GouchiAkira
en-aut-sei=Gouchi
en-aut-mei=Akira
kn-aut-name=合地明
kn-aut-sei=合地
kn-aut-mei=明
aut-affil-num=5
ORCID=

en-aut-name=KamikawaYasuaki
en-aut-sei=Kamikawa
en-aut-mei=Yasuaki
kn-aut-name=上川康明
kn-aut-sei=上川
kn-aut-mei=康明
aut-affil-num=6
ORCID=

en-aut-name=FuchimotoSadanori
en-aut-sei=Fuchimoto
en-aut-mei=Sadanori
kn-aut-name=淵本定義
kn-aut-sei=淵本
kn-aut-mei=定義
aut-affil-num=7
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=8
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=乳癌
kn-keyword=乳癌
en-keyword=再発乳癌
kn-keyword=再発乳癌
en-keyword=Disease free interval
kn-keyword=Disease free interval
END

start-ver=1.4
cd-journal=joma
no-vol=107
cd-vols=
no-issue=7-8
article-no=
start-page=155
end-page=160
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19950831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Endoscopic esophageal mucosal resection for esophageal mucosal carcinoma
kn-title=食道粘膜癌に対する内視鏡的食道粘膜切除術
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=From December 1992 to October 1994, 15 patients who had esophageal superficial mucosal lesions (18 lesions) underwent endoscopic esophageal mucosal resection (EEMR). Among them, 12 cases and 12 lesions were squamous cell carcinomas. Although perforation complicated this procedure in one patient and hemorrhage in another, these were improvde by conservative treatment. Marked subcutaneous emphysema occurred in the neck and face during EEMR without esophageal perforation in one patient. Therfore the procedure was stopped and the patient underwent radical operation 41 days later. Two of the 12 patients with carcinoma underwent radical operation 30 days after EEMR because pathological study revealed m3 and ly1 in one them and sm1, ly2 and v1 in the other. Radiotherapy was indicated for another patient who had m3, ly0 and v0. In the other patients, the cancerous lesions devaloped within m2, ly0 and v0 except in one who had minimal m3 invasion, and the therapy was completed with only EEMR. The mean period of observation after EEMR was 15.1 months (7-24). Follow-up did not reveal any recurrence of carcinoma in these 9 patients. EEMR seems to be a highly useful method for treatment of esophageal mucosal carcinoma.
en-copyright=
kn-copyright=

en-aut-name=KamikawaYasuaki
en-aut-sei=Kamikawa
en-aut-mei=Yasuaki
kn-aut-name=上川康明
kn-aut-sei=上川
kn-aut-mei=康明
aut-affil-num=1
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=2
ORCID=

en-aut-name=HaisaMinoru
en-aut-sei=Haisa
en-aut-mei=Minoru
kn-aut-name=羽井佐実
kn-aut-sei=羽井佐
kn-aut-mei=実
aut-affil-num=3
ORCID=

en-aut-name=UetsukaHirokazu
en-aut-sei=Uetsuka
en-aut-mei=Hirokazu
kn-aut-name=上塚大一
kn-aut-sei=上塚
kn-aut-mei=大一
aut-affil-num=4
ORCID=

en-aut-name=InoueFumiyuki
en-aut-sei=Inoue
en-aut-mei=Fumiyuki
kn-aut-name=井上文之
kn-aut-sei=井上
kn-aut-mei=文之
aut-affil-num=5
ORCID=

en-aut-name=HamadaMadoka
en-aut-sei=Hamada
en-aut-mei=Madoka
kn-aut-name=濱田円
kn-aut-sei=濱田
kn-aut-mei=円
aut-affil-num=6
ORCID=

en-aut-name=MoriJun
en-aut-sei=Mori
en-aut-mei=Jun
kn-aut-name=森淳
kn-aut-sei=森
kn-aut-mei=淳
aut-affil-num=7
ORCID=

en-aut-name=KanekoAkihisa
en-aut-sei=Kaneko
en-aut-mei=Akihisa
kn-aut-name=金子晃久
kn-aut-sei=金子
kn-aut-mei=晃久
aut-affil-num=8
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=9
ORCID=

en-aut-name=OkabayashiTakahiro
en-aut-sei=Okabayashi
en-aut-mei=Takahiro
kn-aut-name=岡林孝弘
kn-aut-sei=岡林
kn-aut-mei=孝弘
aut-affil-num=10
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=11
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=11
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=12
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=食道粘膜癌
kn-keyword=食道粘膜癌
en-keyword=食道表在癌
kn-keyword=食道表在癌
en-keyword=内視鏡的粘膜切除術
kn-keyword=内視鏡的粘膜切除術
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=11-12
article-no=
start-page=171
end-page=210
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=19990228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Peritoneal dissemination caused by ovarian teratoma-Especially teratomatosis peritonei-from clinicopathalogical research on 156 cases of this century
kn-title=Teratomatosis Peritonei―卵巣奇形腫由来の腹膜播種性病巣に関する文献学的考察：今世紀報告された156例の臨床病理学的検討による集大成―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We performed clinicopathological analyses of peritoneal dissemination caused by ovarian teratoma (PD caused by OV-T), on the English great table of 156 cases in 105 papers published in this century. We classified PD caused by OV-T into 3 categories as follows ; 1. (TP) teratomatosis peritonei (new term) : PD composed by three germ teratomas cells. 2. (GP) gliomatosis peritonei : PD composed by only glia cells. 3. (MIX) mixed type : PD composed by glia and teratoma cells. TP and MIX were newly designated in this present paper. The number of TP, GP and MIX were 22, 95 and 25, respectively. The review of these 156 cases and 105 papers were demonstrated that the clinical features between GP and TP were cleary different. TP had a more tendency of recurrentn character in comparison to GP and MIX, but had a good long survivals resulted by repeated surgical resections.
en-copyright=
kn-copyright=

en-aut-name=KobayashiMasanao
en-aut-sei=Kobayashi
en-aut-mei=Masanao
kn-aut-name=小林正直
kn-aut-sei=小林
kn-aut-mei=正直
aut-affil-num=1
ORCID=

en-aut-name=KobayashiJun-ichi
en-aut-sei=Kobayashi
en-aut-mei=Jun-ichi
kn-aut-name=小林淳一
kn-aut-sei=小林
kn-aut-mei=淳一
aut-affil-num=2
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=3
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=小林病院　外科

affil-num=2
en-affil=
kn-affil=小林病院　外科

affil-num=3
en-affil=
kn-affil=岡山大学医学部外科学第一講座

affil-num=4
en-affil=
kn-affil=岡山大学医学部外科学第一講座
en-keyword=ovarian teratoma
kn-keyword=ovarian teratoma
en-keyword=peritoneal dissemination
kn-keyword=peritoneal dissemination
en-keyword=teratomatosis peritonei
kn-keyword=teratomatosis peritonei
en-keyword=gliomatosis peritonei
kn-keyword=gliomatosis peritonei
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=7-10
article-no=
start-page=129
end-page=137
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19981030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第135回　岡山外科会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=1-6
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of living related liver transplantation for an adult recipient with primary biliary cirrhosis
kn-title=原発性胆汁性肝硬変に対する成人生体部分肝移植の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 49-year-old female received a living related liver transplantation from her son. She had a 13-years history of primary biliary cirrhosis (PBC). The preoperative 1-year survival rate and mortality after 6 months were calculated to be 6.5% and 99.3%, respectively. The graft included left bisegments weighing 435g, and was equal to 43% of the calculated standard liver volume. Massive ascites were sustained due to accompanied portal hypertension. On Postoperative day 7, she manifested massive tarry stool by portal-hypertensive colonopathy. The CT scan revealed a right subphrenic abscess on the postoparative day 14. After drainage of the abscess, the serum total billirubin level decreased to the norman range. She was descharged with extracorptreal tube dainage. On the postoperative day 169, she was readmitted due to acute elevation of the serum bilirubin level. Echography revealed selective dilatation of the hepatic bile duct in the segment 2, and suggested the presence of insufficiency of hepatico-jejunostomy in the early postoperative phase. Despite emergent PTCD, jaundice was sustained and responded poorly to steroid pulse therapy. According to tapering of oral prednisolone, the serum bilirubin level gradually decreased and reached a the plateau between 2 and 4mg/dl. The patient is currently completely free from oral steroid therapy and in receiving interventional hepaticoplasty using the YAG laser system. We concluded that living related liver transplantation is an effective transplantational option for adult end-stage liver disease.
en-copyright=
kn-copyright=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=1
ORCID=

en-aut-name=UrushiharaNaoto
en-aut-sei=Urushihara
en-aut-mei=Naoto
kn-aut-name=漆原直人
kn-aut-sei=漆原
kn-aut-mei=直人
aut-affil-num=2
ORCID=

en-aut-name=OishiMasahiro
en-aut-sei=Oishi
en-aut-mei=Masahiro
kn-aut-name=大石正博
kn-aut-sei=大石
kn-aut-mei=正博
aut-affil-num=3
ORCID=

en-aut-name=MatsukawaHiroyoshi
en-aut-sei=Matsukawa
en-aut-mei=Hiroyoshi
kn-aut-name=松川啓義
kn-aut-sei=松川
kn-aut-mei=啓義
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=藤原俊哉
kn-aut-sei=藤原
kn-aut-mei=俊哉
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松野剛
kn-aut-sei=松野
kn-aut-mei=剛
aut-affil-num=6
ORCID=

en-aut-name=MoriMasanobu
en-aut-sei=Mori
en-aut-mei=Masanobu
kn-aut-name=森雅信
kn-aut-sei=森
kn-aut-mei=雅信
aut-affil-num=7
ORCID=

en-aut-name=TsugeHiromu
en-aut-sei=Tsuge
en-aut-mei=Hiromu
kn-aut-name=津下宏
kn-aut-sei=津下
kn-aut-mei=宏
aut-affil-num=8
ORCID=

en-aut-name=TakakuraNorihisa
en-aut-sei=Takakura
en-aut-mei=Norihisa
kn-aut-name=高倉範尚
kn-aut-sei=高倉
kn-aut-mei=範尚
aut-affil-num=9
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=10
ORCID=

en-aut-name=HigashiToshihiro
en-aut-sei=Higashi
en-aut-mei=Toshihiro
kn-aut-name=東俊宏
kn-aut-sei=東
kn-aut-mei=俊宏
aut-affil-num=11
ORCID=

en-aut-name=TsujiTakao
en-aut-sei=Tsuji
en-aut-mei=Takao
kn-aut-name=辻孝夫
kn-aut-sei=辻
kn-aut-mei=孝夫
aut-affil-num=12
ORCID=

en-aut-name=InagakiMasaru
en-aut-sei=Inagaki
en-aut-mei=Masaru
kn-aut-name=稲垣優
kn-aut-sei=稲垣
kn-aut-mei=優
aut-affil-num=13
ORCID=

en-aut-name=SadamoriHiroshi
en-aut-sei=Sadamori
en-aut-mei=Hiroshi
kn-aut-name=貞森裕
kn-aut-sei=貞森
kn-aut-mei=裕
aut-affil-num=14
ORCID=

en-aut-name=KamikawaYasuaki
en-aut-sei=Kamikawa
en-aut-mei=Yasuaki
kn-aut-name=上川康明
kn-aut-sei=上川
kn-aut-mei=康明
aut-affil-num=15
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=2
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=3
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=4
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=5
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=6
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=7
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=8
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=9
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=10
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=11
en-affil=
kn-affil=岡山大学内科学第一講座

affil-num=12
en-affil=
kn-affil=岡山大学内科学第一講座

affil-num=13
en-affil=
kn-affil=高知県立中央病院外科

affil-num=14
en-affil=
kn-affil=福山市民病院

affil-num=15
en-affil=
kn-affil=三原赤十字病院
en-keyword=living related
kn-keyword=living related
en-keyword=liver transplantation
kn-keyword=liver transplantation
en-keyword=primary biliary cirrhosis
kn-keyword=primary biliary cirrhosis
en-keyword=adult
kn-keyword=adult
END

start-ver=1.4
cd-journal=joma
no-vol=109
cd-vols=
no-issue=7-12
article-no=
start-page=181
end-page=191
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19971225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第133回　岡山外科会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=3-6
article-no=
start-page=83
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960629
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Comparison of postoperative circulatory, respiratory and immunological parameters between one-stage and two-stage surgery of intrathoracic esophageal carcinoma
kn-title=循環，呼吸，免疫動態よりみた胸部食道癌に対する1期的手術と分割手術との比較検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=There are two major surgical procedures for excision of esophageal carcinoma and reconstruction of the esophagus: the one-stage procedure and the two-stage procedure. In the present study, we evaluated the two methods by comparing the cardiovascular, respiratory and immune parameters of 10 patients who underwent one-stage procedure with those of 10 other patients who underwent two-stage procedure. To estimate cardiovascular function, we measured the left ventricular stroke work index (LVSWI)-pulmonary capillary wedge pressure (PCWP). Most of the patients treated by the one-stage procedure showed a significant decrease in LVSWI-PCWP, whereas the index of patients treated by the two-stage procedure did not change much. When we assessed the respiratory system by forced vital capacity (FVC) and peak expiratory flow (PEF), the patients treated by the two-stage procedure recovered much faster and better than those receiving the one-stage procedure. Natural killer (NK) activity in lymphocytes was also measured as a marker of the immuno-reactive system. Although most patients show a drop in NK activity one week after major surgery, NK activity did not demonstrate a significant change in any of the patients who underwent the two-stage procedume. Thus, our systemic comparison of the three different parameters demonstrated better results after the two-stage procedure and we recommend it over the one-stage procedure, especially for aged and high risk patients.
en-copyright=
kn-copyright=

en-aut-name=MuramatsuTomoyoshi
en-aut-sei=Muramatsu
en-aut-mei=Tomoyoshi
kn-aut-name=村松友義
kn-aut-sei=村松
kn-aut-mei=友義
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=intrathoracic esophageal carcinoma
kn-keyword=intrathoracic esophageal carcinoma
en-keyword=one-stage procedure
kn-keyword=one-stage procedure
en-keyword=two-stage procedure
kn-keyword=two-stage procedure
en-keyword=reduction of operative stress
kn-keyword=reduction of operative stress
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=3-6
article-no=
start-page=71
end-page=82
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960629
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Prevention of peritoneal dissemination and serosal invasion of digestive tract cancer in an experimental murine model
kn-title=癌漿膜浸潤および腹膜播種の防止に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report a novel prophylactic strategy for peritoneal dissemination and serosal invasion of digestive tract cancer in a murine model, in which the murine abdominal wall was compared to the wall of the human digestive tract. Subcutaneous injection of MH-134 cells to the abdominal wall of C3H mice induced tumors on the parietal peritoneum, and eventually caused peritoneal dissemination with time. In this model, the intraperitoneal administration of OK-432, a type of biological response modifier, after tumor implantation significantly inhibited the development of peritoneal dissemination of tumor cells. This effect was more profound in mice with tumors that extended to the peritoneal surface (designated as S1 stage). Histological examination revealed both the remarkable necrosis of tumoral tissue and the formation of a collagen fiber at the edge of the tumor. This antitumoral effect of OK-432 is thought to be mediated by both macrophages and lymphocytes migrated into the peritoneal cavity, because the administration of Carrageenan and anti-lymphocyte serum completely blocked the antitumoral effect of OK-432.
en-copyright=
kn-copyright=

en-aut-name=IijimaTakashi
en-aut-sei=Iijima
en-aut-mei=Takashi
kn-aut-name=飯島崇史
kn-aut-sei=飯島
kn-aut-mei=崇史
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=漿膜浸潤
kn-keyword=漿膜浸潤
en-keyword=腹膜播種性転移
kn-keyword=腹膜播種性転移
en-keyword=OK-432
kn-keyword=OK-432
en-keyword=細胞性間質反応
kn-keyword=細胞性間質反応
en-keyword=線維性間質反応
kn-keyword=線維性間質反応
END

start-ver=1.4
cd-journal=joma
no-vol=113
cd-vols=
no-issue=2
article-no=
start-page=159
end-page=164
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20010831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of polycystic liver disease
kn-title=多発性肝嚢胞の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 45-year-old female was admitted to our hospital with sever abdominal fullness, and was diagnosed as polycystic liver disease with ultrasonography, abdominal CT and abdominal angiography. Almost all part of the right lobe of the liver was replaced with a lot of cysts. The liver obviously swelled up. We thought her symptom came from oppression of the digestive tract by the liver. Liver function is good. Right lobe resection, deroofing and fenestration were performed, and after operation the volume of the liver was reduced and the symptom got better. We report a case of polycystic liver disease improved with surgical therapy, adding some study with reference.
en-copyright=
kn-copyright=

en-aut-name=NakanishiYutaka
en-aut-sei=Nakanishi
en-aut-mei=Yutaka
kn-aut-name=中村豊
kn-aut-sei=中村
kn-aut-mei=豊
aut-affil-num=1
ORCID=

en-aut-name=SakaguchiKohsaku
en-aut-sei=Sakaguchi
en-aut-mei=Kohsaku
kn-aut-name=坂口孝作
kn-aut-sei=坂口
kn-aut-mei=孝作
aut-affil-num=2
ORCID=

en-aut-name=IwasakiYoshiaki
en-aut-sei=Iwasaki
en-aut-mei=Yoshiaki
kn-aut-name=岩崎良章
kn-aut-sei=岩崎
kn-aut-mei=良章
aut-affil-num=3
ORCID=

en-aut-name=NousoKazuhiro
en-aut-sei=Nouso
en-aut-mei=Kazuhiro
kn-aut-name=能祖一裕
kn-aut-sei=能祖
kn-aut-mei=一裕
aut-affil-num=4
ORCID=

en-aut-name=ShimomuraHiroyuki
en-aut-sei=Shimomura
en-aut-mei=Hiroyuki
kn-aut-name=下村宏之
kn-aut-sei=下村
kn-aut-mei=宏之
aut-affil-num=5
ORCID=

en-aut-name=MatsudaHiroaki
en-aut-sei=Matsuda
en-aut-mei=Hiroaki
kn-aut-name=松田浩明
kn-aut-sei=松田
kn-aut-mei=浩明
aut-affil-num=6
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=7
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=8
ORCID=

en-aut-name=TsujiTakao
en-aut-sei=Tsuji
en-aut-mei=Takao
kn-aut-name=辻孝夫
kn-aut-sei=辻
kn-aut-mei=孝夫
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器・肝臓・感染症内科学 (第一内科）

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器・肝臓・感染症内科学 (第一内科）

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器・肝臓・感染症内科学 (第一内科）

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器・肝臓・感染症内科学 (第一内科）

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器・肝臓・感染症内科学 (第一内科）

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器・腫瘍外科学 （第一外科）

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器・腫瘍外科学 （第一外科）

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器・腫瘍外科学 （第一外科）

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器・肝臓・感染症内科学 (第一内科）
en-keyword=polycystic liver disease
kn-keyword=polycystic liver disease
en-keyword=外科的療法
kn-keyword=外科的療法
en-keyword=cerebral aneurysm
kn-keyword=cerebral aneurysm
END

start-ver=1.4
cd-journal=joma
no-vol=113
cd-vols=
no-issue=2
article-no=
start-page=125
end-page=132
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20010831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=外科的侵襲の分子生物学的解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=守本芳典
kn-aut-sei=守本
kn-aut-mei=芳典
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=日伝晶夫
kn-aut-sei=日伝
kn-aut-mei=晶夫
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器腫瘍外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器腫瘍外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器腫瘍外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科 消化器腫瘍外科学
en-keyword=surgical stress
kn-keyword=surgical stress
en-keyword=bacterial insult
kn-keyword=bacterial insult
en-keyword=operative stress
kn-keyword=operative stress
en-keyword=cancer-burden state
kn-keyword=cancer-burden state
en-keyword=cytokine
kn-keyword=cytokine
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=3
article-no=
start-page=243
end-page=251
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=肝臓を標的とした細胞療法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KobayashiNaoya
en-aut-sei=Kobayashi
en-aut-mei=Naoya
kn-aut-name=小林直哉
kn-aut-sei=小林
kn-aut-mei=直哉
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=興津輝
kn-aut-sei=興津
kn-aut-mei=輝
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=都津川敏範
kn-aut-sei=都津川
kn-aut-mei=敏範
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=丸山昌伸
kn-aut-sei=丸山
kn-aut-mei=昌伸
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小坂芳和
kn-aut-sei=小坂
kn-aut-mei=芳和
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=荒田尚司
kn-aut-sei=荒田
kn-aut-mei=尚司
aut-affil-num=6
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小林和也
kn-aut-sei=小林
kn-aut-mei=和也
aut-affil-num=7
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=野口洋文
kn-aut-sei=野口
kn-aut-mei=洋文
aut-affil-num=8
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=大橋一郎
kn-aut-sei=大橋
kn-aut-mei=一郎
aut-affil-num=9
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=国枝武美
kn-aut-sei=国枝
kn-aut-mei=武美
aut-affil-num=10
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=柴田憲邦
kn-aut-sei=柴田
kn-aut-mei=憲邦
aut-affil-num=11
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=武居道彦
kn-aut-sei=武居
kn-aut-mei=道彦
aut-affil-num=12
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=尾下瑞子
kn-aut-sei=尾下
kn-aut-mei=瑞子
aut-affil-num=13
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=林伸幸
kn-aut-sei=林
kn-aut-mei=伸幸
aut-affil-num=14
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=中路修平
kn-aut-sei=中路
kn-aut-mei=修平
aut-affil-num=15
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=大元謙二
kn-aut-sei=大元
kn-aut-mei=謙二
aut-affil-num=16
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=倉林譲
kn-aut-sei=倉林
kn-aut-mei=譲
aut-affil-num=17
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山本晋一郎
kn-aut-sei=山本
kn-aut-mei=晋一郎
aut-affil-num=18
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=19
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　麻酔蘇生学科

affil-num=10
en-affil=
kn-affil=川崎医科大学消化器Ⅰ内科

affil-num=11
en-affil=
kn-affil=川崎医科大学消化器Ⅰ内科

affil-num=12
en-affil=
kn-affil=川崎医科大学消化器Ⅰ内科

affil-num=13
en-affil=
kn-affil=クラレ・メディカル株式会社　メディカル商品開発部

affil-num=14
en-affil=
kn-affil=クラレ・メディカル株式会社　メディカル商品開発部

affil-num=15
en-affil=
kn-affil=クラレ・メディカル株式会社　メディカル商品開発部

affil-num=16
en-affil=
kn-affil=川崎医科大学消化器Ⅰ内科

affil-num=17
en-affil=
kn-affil=岡山大学医学部付属動物実験施設

affil-num=18
en-affil=
kn-affil=川崎医科大学消化器Ⅰ内科

affil-num=19
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科
en-keyword=バイオ人工肝臓
kn-keyword=バイオ人工肝臓
en-keyword=不死化肝臓細胞
kn-keyword=不死化肝臓細胞
en-keyword=Cre/loxP 部位特異的組換え反応
kn-keyword=Cre/loxP 部位特異的組換え反応
en-keyword=reversible immortalization
kn-keyword=reversible immortalization
END

start-ver=1.4
cd-journal=joma
no-vol=115
cd-vols=
no-issue=2
article-no=
start-page=119
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of adult Meckel's diveticul um with gastrointestinal bleeding
kn-title=下血を主訴として発見された成人 Meckel 憩室に1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Gastrointestinal bleeding is often intermittent and its souree may be difficult to locate, resulting in delay of definitve diagnosis. Melena usually denotes bleeding not only from the upper, and lower gastrointestine but from the small int estine. Adult Meckel's diverticulum with gastrointestinal beeding is a relatively rare disease and  often presents difficulty in preoperative diagnosis. A 65-year-old man was admitted to our hospital due to melena. Upper and lower gastrointestional endoscopy revealed no  bleeding stie. (99m)Tc-pertechnetate scintigraphy is well known as a useful tool for preoperative delineation of Meckel's diverticulm. (99m)Tc-pertechnetate scintigraphy was performed in this patient and succesfully depicted the lesion noninvasively. In surgery, Meckel's diverticulum was found at an oral stie 90 cm from the terminalileum, and a sleevereseection was performed. Histopathologically, the diver ticulum had ectopic gastric muco sa and two 5mm ulcers on the border of the gastric mucosa.
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en-affil=
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affil-num=8
en-affil=
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affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科　消化器・肝臓・感染症内科学

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en-affil=
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en-affil=
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kn-keyword=99mTc-pertechnetateシンチグラフィ
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cd-journal=joma
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kn-title=ヒトの大腸癌細胞におけるTNFとINF-αの併用刺激によるApoptosisの増強のメカニズム, 特にNF-κBが誘導するFasの発現の増強を介した新しいシグナル伝達について―岡山大学医学賞（林原賞）を受賞して―
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END

start-ver=1.4
cd-journal=joma
no-vol=117
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kn-title=蛋白導入システムによる薬剤開発と膵島移植への応用
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END

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kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学
en-keyword=Colorectal Cancer
kn-keyword=Colorectal Cancer
en-keyword=MSI
kn-keyword=MSI
en-keyword=DNA Methylation
kn-keyword=DNA Methylation
en-keyword=KRAS mutation
kn-keyword=KRAS mutation
en-keyword=BRAF mutation
kn-keyword=BRAF mutation
END

start-ver=1.4
cd-journal=joma
no-vol=118
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=45
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20060501
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Two cases of acute pulmonary embolism after esophageal cancer operation
kn-title=早期診断し得た食道癌術後静脈血栓塞栓症の2例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We encountered two cases of pulmonary embolism (PE)/venous thrombs (DVT) after surgery for esophageal cancer. The first case was a 58-year-old male. He underwent a subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. His postoperative course was stable; however, 13 days after the operation､ he had an elevated fever and pulmonary thrombi were observed on CT-scan screening. Scintigraphy confirmed the thrombi. An inferior vena cava filter (IVCF) was inserted and anti-coagulation therapy using heparin was started. His fever subsided, and 35 days after the operation, the thrombi disappeared. He was discharged thereafter and is being followed up using warfarin. The second case was a 74-year-old male. He also underwent subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. A central line was inserted via right femoral vein; however, the artery was injured and pressurization to the vessel was needed. His post-operative course was stable and symptom-free; however, ultrasound screening detected DVT in his right femoral vein. IVCF was mserted and anti-coagulation therapy was begun, thrombi disappeared 8 days after the therapy.
en-copyright=
kn-copyright=

en-aut-name=KanazawaTakashi
en-aut-sei=Kanazawa
en-aut-mei=Takashi
kn-aut-name=金澤卓
kn-aut-sei=金澤
kn-aut-mei=卓
aut-affil-num=1
ORCID=

en-aut-name=WatababeNobuyuki
en-aut-sei=Watababe
en-aut-mei=Nobuyuki
kn-aut-name=渡辺信之
kn-aut-sei=渡辺
kn-aut-mei=信之
aut-affil-num=2
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=3
ORCID=

en-aut-name=KobayashiMasahiko
en-aut-sei=Kobayashi
en-aut-mei=Masahiko
kn-aut-name=小林正彦
kn-aut-sei=小林
kn-aut-mei=正彦
aut-affil-num=4
ORCID=

en-aut-name=ShirakawaYasuhiro
en-aut-sei=Shirakawa
en-aut-mei=Yasuhiro
kn-aut-name=白川靖博
kn-aut-sei=白川
kn-aut-mei=靖博
aut-affil-num=5
ORCID=

en-aut-name=YamatsujiTomoki
en-aut-sei=Yamatsuji
en-aut-mei=Tomoki
kn-aut-name=山辻知樹
kn-aut-sei=山辻
kn-aut-mei=知樹
aut-affil-num=6
ORCID=

en-aut-name=KobayashiNaoya
en-aut-sei=Kobayashi
en-aut-mei=Naoya
kn-aut-name=小林直哉
kn-aut-sei=小林
kn-aut-mei=直哉
aut-affil-num=7
ORCID=

en-aut-name=FujiwaraTohsiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Tohsiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=8
ORCID=

en-aut-name=MatsubaraNagahide
en-aut-sei=Matsubara
en-aut-mei=Nagahide
kn-aut-name=松原長秀
kn-aut-sei=松原
kn-aut-mei=長秀
aut-affil-num=9
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=10
ORCID=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=松岡順治
kn-aut-sei=松岡
kn-aut-mei=順治
aut-affil-num=11
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=12
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学
en-keyword=食道癌 (esophageal cancer)
kn-keyword=食道癌 (esophageal cancer)
en-keyword=肺塞栓症 (pulmonary embolism)
kn-keyword=肺塞栓症 (pulmonary embolism)
en-keyword=深部静脈血栓症 (deep venous thrombs)
kn-keyword=深部静脈血栓症 (deep venous thrombs)
END

start-ver=1.4
cd-journal=joma
no-vol=118
cd-vols=
no-issue=2
article-no=
start-page=123
end-page=125
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20060901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Duct lavage cytology for the detection of breast cancer: report of a case
kn-title=乳管洗浄細胞診が診断に有効であった乳癌の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although many modalities have been established to diagnose breast cancers, it is sometimes difficult to reveal nonpalpable cases. Duct lavage cytology was originally established to reveal groups at high risk for breast cancers by detecting metaplastic ductal cells. We report here a case where duct lavage was useful for revealing a small cancer that had been undetected by repeated bloody nipple discharge and cytological examinations. Duct lavage cytology may be of use in cases where nipple discharge of unknown origin persists.
en-copyright=
kn-copyright=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=松岡順治
kn-aut-sei=松岡
kn-aut-mei=順治
aut-affil-num=1
ORCID=

en-aut-name=TabuchiYoko
en-aut-sei=Tabuchi
en-aut-mei=Yoko
kn-aut-name=田渕陽子
kn-aut-sei=田渕
kn-aut-mei=陽子
aut-affil-num=2
ORCID=

en-aut-name=OnoRyoko
en-aut-sei=Ono
en-aut-mei=Ryoko
kn-aut-name=小野亮子
kn-aut-sei=小野
kn-aut-mei=亮子
aut-affil-num=3
ORCID=

en-aut-name=ImadaTakako
en-aut-sei=Imada
en-aut-mei=Takako
kn-aut-name=今田孝子
kn-aut-sei=今田
kn-aut-mei=孝子
aut-affil-num=4
ORCID=

en-aut-name=UmeokaTatsuo
en-aut-sei=Umeoka
en-aut-mei=Tatsuo
kn-aut-name=梅岡達生
kn-aut-sei=梅岡
kn-aut-mei=達生
aut-affil-num=5
ORCID=

en-aut-name=WatanabeNaoki
en-aut-sei=Watanabe
en-aut-mei=Naoki
kn-aut-name=渡辺直樹
kn-aut-sei=渡辺
kn-aut-mei=直樹
aut-affil-num=6
ORCID=

en-aut-name=MotokiTakayuki
en-aut-sei=Motoki
en-aut-mei=Takayuki
kn-aut-name=元木崇之
kn-aut-sei=元木
kn-aut-mei=崇之
aut-affil-num=7
ORCID=

en-aut-name=MatsukawaHiroyosi
en-aut-sei=Matsukawa
en-aut-mei=Hiroyosi
kn-aut-name=松川啓義
kn-aut-sei=松川
kn-aut-mei=啓義
aut-affil-num=8
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=9
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=10
ORCID=

en-aut-name=YanaiHiroyuki
en-aut-sei=Yanai
en-aut-mei=Hiroyuki
kn-aut-name=柳井広之
kn-aut-sei=柳井
kn-aut-mei=広之
aut-affil-num=11
ORCID=

en-aut-name=OmoriMasako
en-aut-sei=Omori
en-aut-mei=Masako
kn-aut-name=大森昌子
kn-aut-sei=大森
kn-aut-mei=昌子
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学

affil-num=11
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　病理部

affil-num=12
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　病理部
en-keyword=乳管洗浄細胞診 (Ductal lavage cytology)
kn-keyword=乳管洗浄細胞診 (Ductal lavage cytology)
en-keyword=乳癌 (breast cancer)
kn-keyword=乳癌 (breast cancer)
en-keyword=診断 (diagnosis)
kn-keyword=診断 (diagnosis)
END

start-ver=1.4
cd-journal=joma
no-vol=118
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20060501
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=テロメラーゼ特異的に増幅するGFP蛋白を用いたマウスの固形腫瘍の胸膜播種の可視化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=梅岡達生
kn-aut-sei=梅岡
kn-aut-mei=達生
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=川嶋健
kn-aut-sei=川嶋
kn-aut-mei=健
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=香川俊輔
kn-aut-sei=香川
kn-aut-mei=俊輔
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=寺石文則
kn-aut-sei=寺石
kn-aut-mei=文則
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=滝正樹
kn-aut-sei=滝
kn-aut-mei=正樹
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=京哲
kn-aut-sei=京
kn-aut-mei=哲
aut-affil-num=6
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=永井勝幸
kn-aut-sei=永井
kn-aut-mei=勝幸
aut-affil-num=7
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=浦田泰生
kn-aut-sei=浦田
kn-aut-mei=泰生
aut-affil-num=8
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=9
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学

affil-num=6
en-affil=
kn-affil=金沢大学医学部　産婦人科学

affil-num=7
en-affil=
kn-affil=オンコリス．バイオファーマ

affil-num=8
en-affil=
kn-affil=オンコリス．バイオファーマ

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学
en-keyword=GFP
kn-keyword=GFP
en-keyword=アデノウイルス
kn-keyword=アデノウイルス
en-keyword=テロメラーゼ
kn-keyword=テロメラーゼ
en-keyword=増幅
kn-keyword=増幅
en-keyword=遺伝子治療
kn-keyword=遺伝子治療
END

start-ver=1.4
cd-journal=joma
no-vol=118
cd-vols=
no-issue=2
article-no=
start-page=119
end-page=121
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=20060901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Discrepancies between pathological examination and imaging analysis after primary systemic chemotherapy for breast cancer: report of two cases
kn-title=乳癌術前化学療法の効果判定における画像診断 われわれが経験した病理判定と画像診断の不一致症例について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Primary systemic chemotherapy (PSC) in breast cancer prolongs disease-free survival in patients who have obtained pathological complete remission (pCR). In combination with pathological examination, CT and MRI have been used to
evaluate the efficacy of PSC, they generally coincide well with pathological evaluation. We here present two cases showing discrepancies between pathological examination and imaging analysis after PSC in breast cancer. We should
keep such discrepancies in mind to determine the ideal treatment after PSC. An accurate method of evaluating cellular damage by PSC is needed.
en-copyright=
kn-copyright=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=松岡順治
kn-aut-sei=松岡
kn-aut-mei=順治
aut-affil-num=1
ORCID=

en-aut-name=TabuchiYoko
en-aut-sei=Tabuchi
en-aut-mei=Yoko
kn-aut-name=田渕陽子
kn-aut-sei=田渕
kn-aut-mei=陽子
aut-affil-num=2
ORCID=

en-aut-name=ItoMitsuya
en-aut-sei=Ito
en-aut-mei=Mitsuya
kn-aut-name=伊藤充矢
kn-aut-sei=伊藤
kn-aut-mei=充矢
aut-affil-num=3
ORCID=

en-aut-name=OnoRyoko
en-aut-sei=Ono
en-aut-mei=Ryoko
kn-aut-name=小野亮子
kn-aut-sei=小野
kn-aut-mei=亮子
aut-affil-num=4
ORCID=

en-aut-name=ImadaTakako
en-aut-sei=Imada
en-aut-mei=Takako
kn-aut-name=今田孝子
kn-aut-sei=今田
kn-aut-mei=孝子
aut-affil-num=5
ORCID=

en-aut-name=MotokiTakayuki
en-aut-sei=Motoki
en-aut-mei=Takayuki
kn-aut-name=元木崇之
kn-aut-sei=元木
kn-aut-mei=崇之
aut-affil-num=6
ORCID=

en-aut-name=MatsukawaHiroyosi
en-aut-sei=Matsukawa
en-aut-mei=Hiroyosi
kn-aut-name=松川啓義
kn-aut-sei=松川
kn-aut-mei=啓義
aut-affil-num=7
ORCID=

en-aut-name=OhmoriMasako
en-aut-sei=Ohmori
en-aut-mei=Masako
kn-aut-name=大森昌子
kn-aut-sei=大森
kn-aut-mei=昌子
aut-affil-num=8
ORCID=

en-aut-name=YanaiHiroyuki
en-aut-sei=Yanai
en-aut-mei=Hiroyuki
kn-aut-name=柳井広之
kn-aut-sei=柳井
kn-aut-mei=広之
aut-affil-num=9
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=10
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科

affil-num=2
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kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科

affil-num=3
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kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科

affil-num=4
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科

affil-num=5
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kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科

affil-num=6
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科

affil-num=7
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科

affil-num=8
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　病理部

affil-num=9
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　病理部

affil-num=10
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kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科

affil-num=11
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科
en-keyword=術前化学療法（Primary Systemic Chemotherapy）
kn-keyword=術前化学療法（Primary Systemic Chemotherapy）
en-keyword=画像診断（Imaging Analysis）
kn-keyword=画像診断（Imaging Analysis）
en-keyword=MRI
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en-keyword=CT
kn-keyword=CT
END

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cd-journal=joma
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en-title=
kn-title=気管冷却下に施行した縦隔リンパ節転移に対するラジオ波焼灼療法
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kn-affil=岡山大学大学院医歯薬学総合研究科

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kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=10
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kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=11
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kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=12
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kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=13
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kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=14
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kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=15
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kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=16
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kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=17
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科
en-keyword=ラジオ波焼灼療法
kn-keyword=ラジオ波焼灼療法
en-keyword=縦隔リンパ節転移
kn-keyword=縦隔リンパ節転移
en-keyword=食道癌
kn-keyword=食道癌
en-keyword=気管冷却
kn-keyword=気管冷却
en-keyword=温度モニタリング
kn-keyword=温度モニタリング
END

start-ver=1.4
cd-journal=joma
no-vol=119
cd-vols=
no-issue=3
article-no=
start-page=229
end-page=234
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Adenoviral p53 gene therapy for lung cancer
kn-title=p53 遺伝子を発現するアデノウイルスベクターを用いた肺癌の遺伝子治療
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit.
en-copyright=
kn-copyright=

en-aut-name=FujiwaraToshiyoshi
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en-aut-mei=Toshiyoshi
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en-aut-name=TanakaNoriaki
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affil-num=1
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院 遺伝子・細胞治療センター

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学
en-keyword=p53 遺伝子
kn-keyword=p53 遺伝子
en-keyword=アデノウイルスベクター (adenovirus vector)
kn-keyword=アデノウイルスベクター (adenovirus vector)
en-keyword=肺癌 (lung cancer)
kn-keyword=肺癌 (lung cancer)
en-keyword=臨床試験 (clinical trial)
kn-keyword=臨床試験 (clinical trial)
END

start-ver=1.4
cd-journal=joma
no-vol=119
cd-vols=
no-issue=2
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start-page=113
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dt-received=
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dt-accepted=
dt-pub-year=2007
dt-pub=20070903
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kn-subject=
en-title=Accumulating DNA methylation in background mucosa plays a role in esophageal squamous cell carcinogenesis
kn-title=食道扁平上皮癌の発癌過程におけるDNAメチル化の役割
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kn-subtitle=
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affil-num=1
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kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 歯科口腔放射線学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 病態探究医学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 分子遺伝学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 分子遺伝学

affil-num=10
en-affil=
kn-affil=Department of Pathology, McGill University

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学

affil-num=12
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学
en-keyword=食道扁平上皮癌
kn-keyword=食道扁平上皮癌
en-keyword=プロモーターメチル化
kn-keyword=プロモーターメチル化
en-keyword=p53遺伝子変異
kn-keyword=p53遺伝子変異
END

start-ver=1.4
cd-journal=joma
no-vol=119
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no-issue=1
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start-page=11
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dt-pub-year=2007
dt-pub=20070501
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kn-title=A human β-cell line for transplantation therapy to control type 1 diabetes
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