start-ver=1.4 cd-journal=joma no-vol=400 cd-vols= no-issue= article-no= start-page=51 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202507 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Lithium- and oxygen-isotope compositions of a Si-rich nebular reservoir determined from chondrule constituents in the Sahara 97103 EH3 chondrite en-subtitle= kn-subtitle= en-abstract= kn-abstract=Here we report the in situ ion-microprobe analyses of the Li- and O-isotope compositions of enstatite, FeO-rich pyroxene, olivine, glass, and cristobalite grains from six chondrule-related objects from the Sahara 97103 EH3 chondrite. The O-isotope composition of the enstatite grains scattered around the intersection between the terrestrial fractionation and primitive chondrule minerals lines. Whereas, that of olivine varied along the primitive chondrule minerals line. Based on the mineralogy, we found cristobalite formed as a result of Si saturation, instead of the reduction of FeO-rich silicates, consistent with Si-enrichment of whole rock enstatite chondrites. Based on the mineralogy and O-isotope compositions, we infer that olivines in some chondrules are relict grains. In chondrules that contained olivine, no abundant niningerite [(Mg,Fe,Mn)S] was observed. Thus, enstatite formation can be explained by the interaction of an olivine precursor with additional SiO2 (Mg2SiO4 + SiO2 → Mg2Si2O6), instead of sulfidation (Mg2SiO4 + S → 1/2 Mg2Si2O6 + MgS + 1/2 O2). Using the equation Mg2SiO4 + SiO2 → Mg2Si2O6 and the O-isotope compositions of enstatite and olivine, the O-isotope composition of the additional SiO2 was estimated. Based on the O-isotope composition, we infer that there could be a Si-rich gas with an elevated Δ17O value similar to, or greater than the second trend line (Δ17O = 0.9 ‰) suggested by Weisberg et al. (2021), during chondrule formation. The variation in the Li-isotope compositions of enstatite and olivine grains from EH3 chondrules is smaller than that for the same phases from CV3 chondrules. The variation in the Li-isotope compositions of the enstatite and olivine grains from EH3 chondrules is also smaller than that of their O-isotope compositions. During the recycling of enstatite-chondrite chondrules, both Li- and O-isotope compositions were homogenized. Although enstatite is the major carrier of Li in EH3 chondrules, the Li-isotope composition (δ7Li) of enstatite is lower than that of whole rock EH3 chondrites, suggesting the existence of a phase with higher δ7Li. Meanwhile, the Li-isotope composition and concentration (δ7Li, [Li]) of enstatite is higher than that of olivine. The Li-isotope composition of the Si-rich gas was estimated to be δ7Li = 1 ‰, using a similar mass-balance calculation as applied for the O-isotope composition. The Li-isotope composition of the Si-rich gas from the enstatite-chondrite-chondrule forming-region, is consistent with that of whole rock EH3 chondrites, and differs significantly from that of the Si-rich gas from the carbonaceous-chondrite-chondrule forming-region (δ7Li = −11 ‰) determined by a previous study. We speculate that the Si-rich gas in the carbonaceous-chondrite-chondrule forming-region maintained the Li-isotope heterogeneity inherited from light lithium synthesized by galactic cosmic-ray spallation in the interstellar medium. en-copyright= kn-copyright= en-aut-name=Douglas-SongTorii en-aut-sei=Douglas-Song en-aut-mei=Torii kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamanakaMasahiro en-aut-sei=Yamanaka en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitagawaHiroshi en-aut-sei=Kitagawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaRyoji en-aut-sei=Tanaka en-aut-mei=Ryoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=PotiszilChristian en-aut-sei=Potiszil en-aut-mei=Christian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KunihiroTak en-aut-sei=Kunihiro en-aut-mei=Tak kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=The Pheasant Memorial Laboratory Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=The Pheasant Memorial Laboratory Institute for Planetary Materials, Okayama University kn-affil= affil-num=3 en-affil=The Pheasant Memorial Laboratory Institute for Planetary Materials, Okayama University kn-affil= affil-num=4 en-affil=The Pheasant Memorial Laboratory Institute for Planetary Materials, Okayama University kn-affil= affil-num=5 en-affil=The Pheasant Memorial Laboratory Institute for Planetary Materials, Okayama University kn-affil= affil-num=6 en-affil=The Pheasant Memorial Laboratory Institute for Planetary Materials, Okayama University kn-affil= affil-num=7 en-affil=The Pheasant Memorial Laboratory Institute for Planetary Materials, Okayama University kn-affil= en-keyword=Lithium kn-keyword=Lithium en-keyword=Oxygen kn-keyword=Oxygen en-keyword=Trace elements kn-keyword=Trace elements en-keyword=Chondrule kn-keyword=Chondrule en-keyword=Enstatite chondrite kn-keyword=Enstatite chondrite en-keyword=SIMS kn-keyword=SIMS en-keyword=Sulfidation kn-keyword=Sulfidation en-keyword=Silicification kn-keyword=Silicification END start-ver=1.4 cd-journal=joma no-vol=653 cd-vols= no-issue= article-no= start-page=119205 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Meteoritic and asteroidal amino acid heterogeneity: Implications for planetesimal alteration conditions and sample return missions en-subtitle= kn-subtitle= en-abstract= kn-abstract=Carbonaceous chondrites (CC) and asteroid return samples contain amino acids (AA), which are essential for an origin of life on the early Earth and can provide important information concerning planetesimal alteration processes. While many studies have investigated AA from CC, separate studies have often found differing abundances for the same meteorite. Accordingly, analytical bias, differing terrestrial contamination levels and intrinsic sample heterogeneity have been proposed as potential reasons. However, current analytical techniques allow for the analysis of several mg-sized samples and can thus enable an investigation of AA heterogeneity within single meteorite specimens. Here, such an analytical technique is applied to characterise the AA in triplicate aliquots of three CCs. The results indicate that CCs are heterogenous in terms of their AA at the mm-scale. Furthermore, the results help to further constrain the effects of planetesimal alteration on organic matter and the requirements of future sample return missions that aim to obtain organic-bearing extraterrestrial materials. en-copyright= kn-copyright= en-aut-name=PotiszilChristian en-aut-sei=Potiszil en-aut-mei=Christian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamanakaMasahiro en-aut-sei=Yamanaka en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KobayashiKatsura en-aut-sei=Kobayashi en-aut-mei=Katsura kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaRyoji en-aut-sei=Tanaka en-aut-mei=Ryoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=3 en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=4 en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=5 en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=6 en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= en-keyword=Carbonaceous chondrite kn-keyword=Carbonaceous chondrite en-keyword=Heterogeneity kn-keyword=Heterogeneity en-keyword=Planetesimal kn-keyword=Planetesimal en-keyword=Aqueous alteration kn-keyword=Aqueous alteration en-keyword=Amino acid and meteorite kn-keyword=Amino acid and meteorite END start-ver=1.4 cd-journal=joma no-vol=965 cd-vols= no-issue=1 article-no= start-page=52 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Unraveling the Cr Isotopes of Ryugu: An Accurate Aqueous Alteration Age and the Least Thermally Processed Solar System Material en-subtitle= kn-subtitle= en-abstract= kn-abstract=The analysis of samples returned from the C-type asteroid Ryugu has drastically advanced our knowledge of the evolution of early solar system materials. However, no consensus has been obtained on the chronological data, which is important for understanding the evolution of the asteroid Ryugu. Here, the aqueous alteration age of Ryugu particles was determined by the Mn–Cr method using bulk samples, yielding an age of 4.13 + 0.62/−0.55 Myr after the formation of Ca–Al-rich inclusions (CAI). The age corresponds to 4563.17 + 0.60/−0.67 Myr ago. The higher 55Mn/52Cr, ε54Cr, and initial ε53Cr values of the Ryugu samples relative to any carbonaceous chondrite samples implies that its progenitor body formed from the least thermally processed precursors in the outermost region of the protoplanetary disk. Despite accreting at different distances from the Sun, the hydrous asteroids (Ryugu and the parent bodies of CI, CM, CR, and ungrouped C2 meteorites) underwent aqueous alteration during a period of limited duration (3.8 ± 1.8 Myr after CAI). These ages are identical to the crystallization age of the carbonaceous achondirtes NWA 6704/6693 within the error. The ε54Cr and initial ε53Cr values of Ryugu and NWA 6704/6693 are also identical, while they show distinct Δ'17O values. This suggests that the precursors that formed the progenitor bodies of Ryugu and NWA 6703/6693 were formed in close proximity and experienced a similar degree of thermal processing in the protosolar nebula. However, the progenitor body of Ryugu was formed by a higher ice/dust ratio, than NWA6703/6693, in the outer region of the protoplanetary disk. en-copyright= kn-copyright= en-aut-name=TanakaRyoji en-aut-sei=Tanaka en-aut-mei=Ryoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=RatnayakeDilan M. en-aut-sei=Ratnayake en-aut-mei=Dilan M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiklusicakNoah en-aut-sei=Miklusicak en-aut-mei=Noah kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KunihiroTak en-aut-sei=Kunihiro en-aut-mei=Tak kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=PotiszilChristian en-aut-sei=Potiszil en-aut-mei=Christian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SakaguchiChie en-aut-sei=Sakaguchi en-aut-mei=Chie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KobayashiKatsura en-aut-sei=Kobayashi en-aut-mei=Katsura kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KitagawaHiroshi en-aut-sei=Kitagawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamanakaMasahiro en-aut-sei=Yamanaka en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeMasanao en-aut-sei=Abe en-aut-mei=Masanao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MiyazakiAkiko en-aut-sei=Miyazaki en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NakatoAiko en-aut-sei=Nakato en-aut-mei=Aiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=NakazawaSatoru en-aut-sei=Nakazawa en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=NishimuraMasahiro en-aut-sei=Nishimura en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=OkadaTatsuaki en-aut-sei=Okada en-aut-mei=Tatsuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=SaikiTakanao en-aut-sei=Saiki en-aut-mei=Takanao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TanakaSatoshi en-aut-sei=Tanaka en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=TeruiFuyuto en-aut-sei=Terui en-aut-mei=Fuyuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=TsudaYuichi en-aut-sei=Tsuda en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=UsuiTomohiro en-aut-sei=Usui en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=WatanabeSei-ichiro en-aut-sei=Watanabe en-aut-mei=Sei-ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=YadaToru en-aut-sei=Yada en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=YogataKasumi en-aut-sei=Yogata en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=YoshikawaMakoto en-aut-sei=Yoshikawa en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= affil-num=1 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=3 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=4 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=5 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=6 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=7 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=8 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=9 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=10 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=11 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=12 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=13 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=14 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=15 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=16 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=17 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=18 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=19 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=20 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=21 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=22 en-affil=Department of Earth and Planetary Sciences, Nagoya University kn-affil= affil-num=23 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=24 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=25 en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency kn-affil= affil-num=26 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺腺癌におけるSPRED2の発現 kn-title=Expression of SPRED2 in the lung adenocarcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OTAYoko en-aut-sei=OTA en-aut-mei=Yoko kn-aut-name=太田陽子 kn-aut-sei=太田 kn-aut-mei=陽子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=1 article-no= start-page=41 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240724 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Der moderne Staat und das Nationalitätenprinzip kn-title=近代国家と民族性原理 オーストロ・マルクス主義の民族政策論争から en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学名誉教授 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=細胞自己凝集化技術を用いたスキャフォールドフリー間葉系組織バンドの作製と組織再生への応用の可能性 kn-title=Fabrication of scaffold-free mesenchyme tissue bands by cell self-aggregation technique for potential use in tissue regeneration en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OTATomoyuki en-aut-sei=OTA en-aut-mei=Tomoyuki kn-aut-name=太田智之 kn-aut-sei=太田 kn-aut-mei=智之 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue= article-no= start-page=207 end-page=219 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Qualitative Study on Teachers’ Reflection in Creative Dance Instruction -Focusing on the “Reflection in Action” of the Experienced Teacher- kn-title=創作ダンス指導における教師の省察に関する質的研究―熟練教師の「行為の中の省察」に焦点を当てて― en-subtitle= kn-subtitle= en-abstract= kn-abstract=本研究は，公立中学校で長年ダンス教育に携わってきた熟練教師O 氏を対象として，D・ショーンが提唱した「行為の中の省察(reflection in action)」という観点から，その実践的指導力の特徴を検討した。分析手法には，再生刺激法を採用した聞き取り調査を行い，M-GTA による質的検討を行った。研究の結果，教師の授業実践中の省察から5 つのコアカテゴリー【教師観】【中学生のダンスへの抵抗感】【即時的な指導】【ダンスの指導観】【指導中の困難感】と12 のサブカテゴリ―と45 の概念が認められた。O 氏の指導には，自主創造性教育を掲げるダンス教育と，規律や規範といった学校文化との狭間における葛藤がみられた。中学生のダンスへの抵抗感をダンス授業の根本的な課題と抱えながらも，自身の身体を介入させた指導方略によって人間関係を重視した集団づくりを核とする指導実践を行っていることが明らかとなった。 en-copyright= kn-copyright= en-aut-name=FukutakeSachiyo en-aut-sei=Fukutake en-aut-mei=Sachiyo kn-aut-name=福武幸世 kn-aut-sei=福武 kn-aut-mei=幸世 aut-affil-num=1 ORCID= en-aut-name=OtaKazue en-aut-sei=Ota en-aut-mei=Kazue kn-aut-name=太田一枝 kn-aut-sei=太田 kn-aut-mei=一枝 aut-affil-num=2 ORCID= en-aut-name=SakoHaruko en-aut-sei=Sako en-aut-mei=Haruko kn-aut-name=酒向治子 kn-aut-sei=酒向 kn-aut-mei=治子 aut-affil-num=3 ORCID= affil-num=1 en-affil=Department o f Early Childhood Care a nd Education , Niimi University kn-affil=新見公立大学健康科学部健康保育学科 affil-num=2 en-affil=Joto Junior High School, Okayama City kn-affil=岡山市立上道中学校 affil-num=3 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 en-keyword=創作ダンス (creative dance) kn-keyword=創作ダンス (creative dance) en-keyword=ダンス指導 (dance instruction) kn-keyword=ダンス指導 (dance instruction) en-keyword=熟練教師 (experienced teacher) kn-keyword=熟練教師 (experienced teacher) en-keyword=行為の中の省察 (reflection in action) kn-keyword=行為の中の省察 (reflection in action) en-keyword=実践的指導力 (practical leadership) kn-keyword=実践的指導力 (practical leadership) END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=1 article-no= start-page=65 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220729 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=エルンスト・パンツェンベック著『一つのドイツの夢：カール・レンナーとオットー・バウアーにおける合邦思想と合邦政策』（御茶の水書房，2022年） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学名誉教授 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=3 article-no= start-page=173 end-page=188 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Kohei Saito’s Two Books kn-title=斎藤幸平著『大洪水の前に』と『人新世の「資本論」』によせて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学名誉教授 END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue=3 article-no= start-page=1020 end-page=1029 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220422 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Lithium in garnet as a tracer of subduction zone metamorphic reactions: The record in ultrahigh-pressure metapelites at Lago di Cignana, Italy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Lithium is of great interest as a tracer of metamorphic reactions and related fluid-mineral interactions because of its potential to isotopically fractionate during inter- and intracrystalline diffusional processes. Study of its transfer through subduction zones, based on study of arc volcanic and metamorphic rocks, can yield insight regarding ocean-to-mantle chemical cycling. We investigated major- and trace-element concentrations and delta Li-7 in garnet in ultrahigh-pressure (UHP) Lago di Cignana metasedimentary rocks, relating these observations to reconstructed prograde devolatilization history. In all garnet crystals we studied, heavy rare earth elements (HREEs), Y, and Li showed strong zoning, with elevated concentrations in cores (15-50 ppm Li) and marked high-concentration anomalies (up to 117 ppm Li, 5500 ppm Y; little or no major-element shift) as growth annuli, in which some crystals showed subtle elevation in delta Li-7 greater than analytical error of similar to 3 parts per thousand (2 sigma). Rutile inclusions appeared abruptly at annuli and outward toward rims, accompanied by inclusions of a highly zoned, Ca- and rare earth element-rich phase and decreased Nb concentrations in garnet. These relationships are interpreted to reflect prograde garnet-forming reaction(s), in part involving titanite breakdown to stabilize rutile, which resulted in delivery of more abundant Y and HREEs at surfaces of growing garnet crystals to produce annuli. Co-enrichments in Li and Y + REEs are attributed to mutual incorporation via charge-coupled substitutions; thus, increased Li uptake was a passive consequence of elevated concentrations of Y + REEs. The small-scale fluctuations in delta Li-7 (overall range of similar to 9 parts per thousand) observed in some crystals may correlate with abrupt shifts in major-and trace-element concentrations, suggesting that changes in reactant phases exerted some control on the evolution of delta Li-7. For one garnet crystal, late-stage growth following partial resorption produced deviation in major- and trace-element compositions, including Li concentration, accompanied by a 10 parts per thousand-15 parts per thousand negative shift in delta Li-7, perhaps reflecting a change in the mechanism of incorporation or source of Li. These results highlight the value of measuring the major- and trace-element and isotope compositions of garnets in high-pressure and UHP metamorphic rocks in which matrix mineral assemblages are extensively overprinted by recrystallization during exhumation histories. Lithium concentrations and isotope compositions of the garnets can add valuable information regarding prograde (and retrograde) reaction history, kinetics of porphyroblast growth, intracrystalline diffusion, and fluid-rock interactions. This work, integrated with previous study of devolatilization in the Schistes Lustres/Cignana metasedimentary suite, indicates retention of a large fraction of the initially subducted sedimentary Li budget to depths approaching those beneath volcanic fronts, despite the redistribution of this Li among mineral phases during complex mineral reaction histories. en-copyright= kn-copyright= en-aut-name=BeboutGray E. en-aut-sei=Bebout en-aut-mei=Gray E. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KunihiroTakuya en-aut-sei=Kunihiro en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=CarlsonWilliam D. en-aut-sei=Carlson en-aut-mei=William D. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=3 en-affil=Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=4 en-affil=Department of Geological Sciences, Jackson School of Geosciences, University of Texas at Austin kn-affil= affil-num=5 en-affil=Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=387 cd-vols= no-issue=15 article-no= start-page=70 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20184 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Familial and sporadic chronic progressive degenerative parietal ataxia en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background & objective: Parietal ataxia has been mainly reported as a consequence of acute ischemic stroke, while degenerative parietal ataxia has not been reported. Methods: We investigated clinical characteristics, neuroimaging data, and genetic analysis of patients with cerebellar ataxia plus parietal atrophy. Results: We identified seven patients, including five patients from two families, with chronic progressive cerebellar ataxia due to degenerative parietal atrophy but not stroke. Age at onset of ataxia was 57.6 +/- 6.9 years. All patients showed chronic progressive cerebellar ataxia with severity of ataxic gait > limb ataxia > dysarthria. Patients showed no cognitive dysfunction, muscle weakness, or parkinsonism, and only two patients showed mild sensory disturbances. The seven patients showed lateralized limb ataxia with greater contralateral parietal lobe atrophy by magnetic resonance imaging, and hypoperfusion by single photon emission computed tomography, without any abnormal cerebellar pathology (i.e., crossed cerebellar diaschisis). Pathogenic mutations in the microtubule-associated protein tau gene were not found using two single nucleotide polymorphisms. Conclusions: This is the first description showing unique clinical features of familial and sporadic chronic progressive degenerative parietal ataxia. en-copyright= kn-copyright= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KurataTomoko en-aut-sei=Kurata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IkeuchiTakeshi en-aut-sei=Ikeuchi en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KitaguchiMasataka en-aut-sei=Kitaguchi en-aut-mei=Masataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=2 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=3 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=4 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=5 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=6 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=7 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=8 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=9 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=10 en-affil=Department of Molecular Genetics, Bioresource Science Branch, Center of Bioresource, Brain Research Institute Niigata University kn-affil= affil-num=11 en-affil=Department of Neurology, Baba Memorial Hospital kn-affil= affil-num=12 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= en-keyword=parietal ataxia kn-keyword=parietal ataxia en-keyword=parietal lobe atrophy kn-keyword=parietal lobe atrophy en-keyword=crossed cerebellar diaschisis kn-keyword=crossed cerebellar diaschisis en-keyword=MAPT kn-keyword=MAPT END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=9 article-no= start-page=1818 end-page=1828 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Downregulation of PAR-1 and PAR-2 by Rivaroxaban kn-title=Reduction of intracerebral hemorrhage by rivaroxaban after tPA thrombolysis is associated with downregulation of PAR-1 and PAR-2 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study aimed to assess the risk of intracerebral hemorrhage (ICH) after tissue-type plasminogen activator (tPA) treatment in rivaroxaban compared with warfarin-pretreated male Wistar rat brain after ischemia in relation to activation profiles of protease-activated receptor-1, -2, -3, and -4 (PAR-1, -2, -3, and -4). After pretreatment with warfarin (0.2 mg/kg/day), low-dose rivaroxaban (60 mg/kg/day), high-dose rivaroxaban (120 mg/kg/day), or vehicle for 14 days, transient middle cerebral artery occlusion was induced for 90 min, followed by reperfusion with tPA (10 mg/kg/10 ml). Infarct volume, hemorrhagic volume, immunoglobulin G leakage, and blood parameters were examined. Twenty-four hours after reperfusion, immunohistochemistry for PARs was performed in brain sections. ICH volume was increased in the warfarin-pretreated group compared with the rivaroxaban-treated group. PAR-1, -2, -3, and -4 were widely expressed in the normal brain, and their levels were increased in the ischemic brain, especially in the peri-ischemic lesion. Warfarin pretreatment enhanced the expression of PAR-1 and PAR-2 in the peri-ischemic lesion, whereas rivaroxaban pretreatment did not. The present study shows a lower risk of brain hemorrhage in rivaroxaban-pretreated compared with warfarin-pretreated rats following tPA administration to the ischemic brain. It is suggested that the relative downregulation of PAR-1 and PAR-2 by rivaroxaban compared with warfarin pretreatment might be partly involved in the mechanism of reduced hemorrhagic complications in patients receiving rivaroxaban in clinical trials. © 2016 Wiley Periodicals, Inc. en-copyright= kn-copyright= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KonoSyoichiro en-aut-sei=Kono en-aut-mei=Syoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HeitmeierStefan en-aut-sei=Heitmeier en-aut-mei=Stefan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=PerzbornElisabeth en-aut-sei=Perzborn en-aut-mei=Elisabeth kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=2 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=3 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=4 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=5 en-affil=Departments of Neurology kn-affil= affil-num=6 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=7 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=8 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=9 en-affil=Bayer Pharma AG, Drug Discovery - Global Therapeutic Research Groups, Cardiovascular Pharmacology kn-affil= affil-num=10 en-affil=Bayer Pharma AG, Drug Discovery - Global Therapeutic Research Groups, Cardiovascular Pharmacology kn-affil= affil-num=11 en-affil=Departments of Neurology, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= en-keyword=PAR-3 kn-keyword=PAR-3 en-keyword=PAR-4 kn-keyword=PAR-4 en-keyword=tissue plasminogen activator kn-keyword=tissue plasminogen activator en-keyword=warfarin kn-keyword=warfarin END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=17 article-no= start-page=2343 end-page=2346 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Successful Delayed Aortic Surgery for a Patient with Ischemic Stroke Secondary to Aortic Dissection en-subtitle= kn-subtitle= en-abstract= kn-abstract=The diagnosis of aortic dissection (AD) is sometimes difficult within the limited time window of recombinant tissue plasminogen activator (tPA) for ischemic stroke (IS). A 60-year-old man developed sudden left hemiparesis due to IS. During tPA infusion, his blood pressure dropped and consciousness declined. After transfer to our hospital, carotid duplex ultrasonography led to a diagnosis of AD. Emergency surgery was postponed because of the risk of hemorrhagic transformation. The patient successfully underwent aortic surgery on day 5 and was discharged with a remarkable improvement in his symptoms. Delayed surgery may avoid hemorrhagic transformation in patients with AD-induced IS who have received tPA. en-copyright= kn-copyright= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsunodaKeiichiro en-aut-sei=Tsunoda en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ManabeYasuhiro en-aut-sei=Manabe en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KonoSyoichiro en-aut-sei=Kono en-aut-mei=Syoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=2 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= affil-num=3 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=4 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama National Hospital Medical Center, Japan kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama National Hospital Medical Center, Japan kn-affil= affil-num=7 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=8 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=9 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=10 en-affil=Department of Neurology, Okayama National Hospital Medical Center, Japan kn-affil= affil-num=11 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=12 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= affil-num=13 en-affil=Departments of Neurology, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Japan kn-affil= END start-ver=1.4 cd-journal=joma no-vol=133 cd-vols= no-issue=2 article-no= start-page=129 end-page=130 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=医療法人緑隆会 太田病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田徹 kn-aut-sei=太田 kn-aut-mei=徹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=医療法人緑隆会 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=1 article-no= start-page=19 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Die Debatte über Nationalitätenpolitik im österreichischen Kaiserreich kn-title=オーストリア帝国における民族政策論争 ―民族性原理をめぐって― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学名誉教授 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210517 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Element concentrations of chondrule constituents, supplement to: Tak Kunihiro et al. (2021): The trace element composition of chondrule constituents: Implications for sample return methodologies and the chondrule silicate reservoir. Meteorit Planet Sci en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KunihiroTak en-aut-sei=Kunihiro en-aut-mei=Tak kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamanakaMasahiro en-aut-sei=Yamanaka en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=3 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=4 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=21 article-no= start-page=3163 end-page=3165 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction en-subtitle= kn-subtitle= en-abstract= kn-abstract=A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck and bilateral upper extremities (R < L), decreased scores on frontal cognitive tests, a decreased accumulation of the right dorsal putamen on a DAT scan, and hypoperfusion of the bilateral frontal lobes on 99mTc-ECD single photon emission computed tomography (SPECT). The present case provides a new spectrum of spastic paraplegia based on the evidence of clinical scores and the findings of brain functional imaging. en-copyright= kn-copyright= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IshiuraHiroyuki en-aut-sei=Ishiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TsujiShoji en-aut-sei=Tsuji en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, The University of Tokyo Hospital kn-affil= affil-num=11 en-affil=Department of Molecular Neurology, The University of Tokyo Hospital, Japan Institute of Medical Genomics, International University of Health and Welfare kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=spastic paraplegia kn-keyword=spastic paraplegia en-keyword=extrapyramidal sign kn-keyword=extrapyramidal sign en-keyword=frontal cognitive dysfunction kn-keyword=frontal cognitive dysfunction END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=7 article-no= start-page=1033 end-page=1036 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C en-subtitle= kn-subtitle= en-abstract= kn-abstract=Werner syndrome (WS) is an autosomal recessive progeroid disorder caused by mutations in the WRN gene (WRN). Most Japanese WS patients are born from a consanguineous marriage with homozygous WRN mutations. We herein report a rare WS patient born from non-consanguineous parents with compound heterozygous WRN mutations with a novel heterogeneous c.1720+1G>A substitution plus the most frequent heterogeneous c.3139-1G>C substitution among Japanese. Although the present case showed clinical characteristics common to previous Japanese WS patients, he had not developed any malignant tumors as of 43 years of age, suggesting that WS patients with this particular genetic mutation have a different phenotype than others. en-copyright= kn-copyright= en-aut-name=MatsumotoNamiko en-aut-sei=Matsumoto en-aut-mei=Namiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KishidaMasayuki en-aut-sei=Kishida en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WatanabeAki en-aut-sei=Watanabe en-aut-mei=Aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YokoteKoutaro en-aut-sei=Yokote en-aut-mei=Koutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TakemotoMinoru en-aut-sei=Takemoto en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OshimaJunko en-aut-sei=Oshima en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama Citizen's Hospital kn-affil= affil-num=4 en-affil=Department of General Internal Medicine, Okayama Citizen's Hospital kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University kn-affil= affil-num=11 en-affil=Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University kn-affil= affil-num=12 en-affil=Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare kn-affil= affil-num=13 en-affil=Department of Pathology, University of Washington kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=werner syndrome kn-keyword=werner syndrome en-keyword=compound heterozygous kn-keyword=compound heterozygous en-keyword=Japanese kn-keyword=Japanese END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=3 article-no= start-page=437 end-page=440 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Rare Case of Klinefelter Syndrome Accompanied by Spastic Paraplegia and Peripheral Neuropathy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Klinefelter syndrome is a chromosomal disorder with a typical karyotype of 47, XXY, accompanied by various neurological symptoms. We herein report the first case of Klinefelter syndrome with a rare mosaic form of 47, XXY and 48, XXXY, combined with both spastic paraplegia and peripheral motor neuropathy. This case showed spasticity and hyperreflexia with pathological reflexes and ankle clonus as well as muscle weakness in all extremities. A motor nerve conduction study and the magnetic motor evoked potential suggested motor axonal neuropathy and corticospinal tract disorders. The present case suggests that Klinefelter syndrome can present with both upper and lower motor neuron degeneration. en-copyright= kn-copyright= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsunodaKeiichiro en-aut-sei=Tsunoda en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Klinefelter syndrome kn-keyword=Klinefelter syndrome en-keyword=mosaic form kn-keyword=mosaic form en-keyword=peripheral neuropathy kn-keyword=peripheral neuropathy en-keyword=spastic paraplegia kn-keyword=spastic paraplegia END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=8 article-no= start-page=1081 end-page=1085 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190415 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Improving Anxiety in Subacute Myelo-optico-neuropathy (SMON) after an Automated Telephone Call Service en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective We evaluated the clinical effects of a telephone call service for psychological symptoms such as anxiety, depression or apathy in subacute myelo-optico-neuropathy (SMON) patients living alone or with a single caregiver.
Methods Up to 16 SMON patients (4 men, 12 women) and 32 control subjects were evaluated by the geriatric depression scale (GDS), apathy scale (AS) and state and trait anxiety inventory (STAI) forms X-I, including the P and A values for depression, apathy and state anxiety including disturbed peace of mind and enhanced anxiety, respectively, before (pre) and three months after (post) the telephone call service.
Results The SMON patients, especially women, had significantly worse baseline scores in GDS (depression), AS (apathy) and STAI (state anxiety) than control subjects. The automated telephone call service significantly improved the high baseline STAI scores, including the P and A scores (disturbed peace of mind and enhanced anxiety), of SMON patients but not the GDS or AS scores.
Conclusion SMON patients, especially women, living alone or with a single caregiver showed higher baseline depression, apathy and anxiety scores than the control subjects. The present automated telephone call service proved to be a useful care tool for improving the anxiety of SMON patients with high STAI P and A scores. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DoutareShinji en-aut-sei=Doutare en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Doutare Medical Clinic kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=anxiety kn-keyword=anxiety en-keyword=SMON kn-keyword=SMON en-keyword=STAI kn-keyword=STAI en-keyword=telephone call service kn-keyword=telephone call service END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1 article-no= start-page=217 end-page=227 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200107 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer’s Disease by Peptidome Technology en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background:
Because dementia is an emerging problem in the world, biochemical markers of cerebrospinal fluid (CSF) and radio-isotopic analyses are helpful for diagnosing Alzheimer’s disease (AD). Although blood sample is more feasible and plausible than CSF or radiological biomarkers for screening potential AD, measurements of serum amyloid- β (Aβ), plasma tau, and serum antibodies for Aβ1 - 42 are not yet well established.
Objective:
We aimed to identify a new serum biomarker to detect mild cognitive impairment (MCI) and AD in comparison to cognitively healthy control by a new peptidome technology.
Methods:
With only 1.5μl of serum, we examined a new target plate “BLOTCHIP®” plus a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) to discriminate control (n = 100), MCI (n = 60), and AD (n = 99). In some subjects, cognitive Mini-Mental State Examination (MMSE) were compared to positron emission tomography (PET) with Pittsburgh compound B (PiB) and the serum probability of dementia (SPD). The mother proteins of candidate serum peptides were examined in autopsied AD brains.
Results:
Apart from Aβ or tau, the present study discovered a new diagnostic 4-peptides-set biomarker for discriminating control, MCI, and AD with 87% of sensitivity and 65% of specificity between control and AD (***p < 0.001). MMSE score was well correlated to brain Aβ deposition and to SPD of AD. The mother proteins of the four peptides were upregulated for coagulation, complement, and plasticity (three proteins), and was downregulated for anti-inflammation (one protein) in AD brains.
Conclusion:
The present serum biomarker set provides a new, rapid, non-invasive, highly quantitative and low-cost clinical application for dementia screening, and also suggests an alternative pathomechanism of AD for neuroinflammation and neurovascular unit damage. en-copyright= kn-copyright= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShiXiaowen en-aut-sei=Shi en-aut-mei=Xiaowen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=DeguchiKentaro en-aut-sei=Deguchi en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IkedaMasaki en-aut-sei=Ikeda en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IkedaYoshio en-aut-sei=Ikeda en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OkamotoKoichi en-aut-sei=Okamoto en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=ShojiMikio en-aut-sei=Shoji en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TakatamaMasamitsu en-aut-sei=Takatama en-aut-mei=Masamitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KojoMotohisa en-aut-sei=Kojo en-aut-mei=Motohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=KurodaTakeshi en-aut-sei=Kuroda en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=OnoKenjiro en-aut-sei=Ono en-aut-mei=Kenjiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=KimuraNoriyuki en-aut-sei=Kimura en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=MatsubaraEtsuro en-aut-sei=Matsubara en-aut-mei=Etsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=OsakadaYosuke en-aut-sei=Osakada en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=WakutaniYosuke en-aut-sei=Wakutani en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=TakaoYoshiki en-aut-sei=Takao en-aut-mei=Yoshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=HigashiYasuto en-aut-sei=Higashi en-aut-mei=Yasuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=AsadaKyoichi en-aut-sei=Asada en-aut-mei=Kyoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=SengaTakehito en-aut-sei=Senga en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= en-aut-name= LeeLyang-Ja en-aut-sei= Lee en-aut-mei=Lyang-Ja kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=27 ORCID= en-aut-name=TanakaKenji en-aut-sei=Tanaka en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=28 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Okayama City Hospital, Okayama kn-affil= affil-num=11 en-affil=Department of Neurology, Gunma University, Graduate School of Medicine kn-affil= affil-num=12 en-affil=Department of Neurology, Gunma University, Graduate School of Medicine kn-affil= affil-num=13 en-affil=Department of Neurology, Geriatrics Research Institute and Hospital kn-affil= affil-num=14 en-affil=Department of Neurology, Geriatrics Research Institute and Hospital kn-affil= affil-num=15 en-affil=Department of Neurology, Geriatrics Research Institute and Hospital kn-affil= affil-num=16 en-affil=Department of Neurology, Ako Chuo Hospital kn-affil= affil-num=17 en-affil=Division of Neurology, Department of Medicine, Showa University, School of Medicine kn-affil= affil-num=18 en-affil=Division of Neurology, Department of Medicine, Showa University, School of Medicine kn-affil= affil-num=19 en-affil=Department of Neurology, Faculty of Medicine, Oita University kn-affil= affil-num=20 en-affil=Department of Neurology, Faculty of Medicine, Oita University kn-affil= affil-num=21 en-affil=Department of Neurology, Kurashiki Heisei Hospital kn-affil= affil-num=22 en-affil=Department of Neurology, Kurashiki Heisei Hospital kn-affil= affil-num=23 en-affil=Department of Neurology, Kurashiki Heisei Hospital kn-affil= affil-num=24 en-affil=Department of Neurology, Himeji Central Hospital kn-affil= affil-num=25 en-affil=Membrane Protein and Ligand Analysis Center, Protosera Inc., kn-affil= affil-num=26 en-affil=Membrane Protein and Ligand Analysis Center, Protosera Inc., kn-affil= affil-num=27 en-affil=Membrane Protein and Ligand Analysis Center, Protosera Inc., kn-affil= affil-num=28 en-affil=Membrane Protein and Ligand Analysis Center, Protosera Inc., kn-affil= en-keyword=Alzheimer’s disease kn-keyword=Alzheimer’s disease en-keyword=biomarker kn-keyword=biomarker en-keyword=coagulation kn-keyword=coagulation en-keyword=complement kn-keyword=complement en-keyword=MALDI-TOF kn-keyword=MALDI-TOF en-keyword=mild cognitive impairment kn-keyword=mild cognitive impairment en-keyword=neuroinflammation kn-keyword=neuroinflammation en-keyword=peptidome kn-keyword=peptidome en-keyword=plasticity kn-keyword=plasticity END start-ver=1.4 cd-journal=joma no-vol=304 cd-vols= no-issue= article-no= start-page=109402 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mineralogical alterations in calcite powder flooded with MgCl2 to study Enhanced Oil Recovery (EOR) mechanisms at pore scale en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seawater injection into chalk-reservoirs on the Norwegian Continental Shelf has increased the oil recovery and reduced seabed subsidence, but not eliminated it. Therefore, understanding rock–fluid interactions is paramount to optimize water injection, predict and control water-induced compaction.
Laboratory experiments on onshore and reservoir chalks have shown the need to simplify the aqueous chemistry of the brine, and also the importance of studying the effect of primary mineralogy of chalk to understand which ions interact with the minerals present. In this study, the mineralogy of the samples tested, are simplified. These experiments are carried out on pure calcite powder (99.95%), compressed to cylinders, flooded with MgCl2, at 130 °C and 0.5 MPa effective stress, for 27 and 289 days.
The tested material was analysed by scanning and transmission electron microscopy, along with whole-rock geochemistry. The results show dissolution of calcite followed by precipitation of magnesite. The occurrence and shape of new-grown crystals depend on flooding time and distance from the flooding inlet of the cylinder. Crystals vary in shape and size, from a few nanometres up to 2 μm after 27 days, and to over 10 μm after 289 days of flooding and may crystallize as a single grain or in clusters.
The population and distribution of new-grown minerals are found to be controlled by nucleation- and growth-rates along with advection of the injected fluid through the cores. Our findings are compared with in-house experiments on chalks, and allow for insight of where, when, and how crystals preferentially grow. en-copyright= kn-copyright= en-aut-name=MindeMona W. en-aut-sei=Minde en-aut-mei=Mona W. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MadlandMerete V. en-aut-sei=Madland en-aut-mei=Merete V. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ZimmermannUdo en-aut-sei=Zimmermann en-aut-mei=Udo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=EgelandNina en-aut-sei=Egeland en-aut-mei=Nina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KorsnesReidar I. en-aut-sei=Korsnes en-aut-mei=Reidar I. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobayashiKatsura en-aut-sei=Kobayashi en-aut-mei=Katsura kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=The National IOR Centre of Norway kn-affil= affil-num=2 en-affil=The National IOR Centre of Norway kn-affil= affil-num=3 en-affil=The National IOR Centre of Norway kn-affil= affil-num=4 en-affil=The National IOR Centre of Norway kn-affil= affil-num=5 en-affil=The National IOR Centre of Norway kn-affil= affil-num=6 en-affil=Institute for Planetary Materials, Okayama University kn-affil= affil-num=7 en-affil=Institute for Planetary Materials, Okayama University kn-affil= affil-num=8 en-affil=Institute for Planetary Materials, Okayama University kn-affil= en-keyword=Mineral replacement reactions kn-keyword=Mineral replacement reactions en-keyword=EOR kn-keyword=EOR en-keyword=Calcite kn-keyword=Calcite en-keyword=FE-SEM kn-keyword=FE-SEM en-keyword=FE-TEM kn-keyword=FE-TEM END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=1 article-no= start-page=17102 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201013 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss. Muse cells are endogenous reparative pluripotent-like stem cells distributed in various tissues. They can selectively home to damaged sites after intravenous injection by sensing sphingosine-1-phosphate produced by damaged cells, then exert pleiotropic effects, including tissue protection and spontaneous differentiation into tissue-constituent cells. In G93A-transgenic ALS mice, intravenous injection of 5.0x10(4) cells revealed successful homing of human-Muse cells to the lumbar spinal cords, mainly at the pia-mater and underneath white matter, and exhibited glia-like morphology and GFAP expression. In contrast, such homing or differentiation were not recognized in human mesenchymal stem cells but were instead distributed mainly in the lung. Relative to the vehicle groups, the Muse group significantly improved scores in the rotarod, hanging-wire and muscle strength of lower limbs, recovered the number of motor neurons, and alleviated denervation and myofiber atrophy in lower limb muscles. These results suggest that Muse cells homed in a lesion site-dependent manner and protected the spinal cord against motor neuron death. Muse cells might also be a promising cell source for the treatment of ALS patients. en-copyright= kn-copyright= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KushidaYoshihiro en-aut-sei=Kushida en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WakaoShohei en-aut-sei=Wakao en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OmoteYoshio en-aut-sei=Omote en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=DezawaMari en-aut-sei=Dezawa en-aut-mei=Mari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine kn-affil= affil-num=11 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Mesenchymal stem cells kn-keyword=Mesenchymal stem cells en-keyword=Neurological disorders kn-keyword=Neurological disorders END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=1 article-no= start-page=111 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=19730331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=「古今・後拾遺・千載・新古今」四歌集の序に見られる訓点特有語の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田紘子 kn-aut-sei=太田 kn-aut-mei=紘子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=10 article-no= start-page=78 end-page=86 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=昔話についての手控え数件――西行話・たとへづくし・その他―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田東雄 kn-aut-sei=太田 kn-aut-mei=東雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=市立岡山商業高校 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=10 article-no= start-page=17 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=『東大寺図書館蔵法華論義草』の出典――経の部―― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田紘子 kn-aut-sei=太田 kn-aut-mei=紘子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=就実女子大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=11 article-no= start-page=1 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=『東大寺図書館蔵法華論義草』の出典―論の部― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田紘子 kn-aut-sei=太田 kn-aut-mei=紘子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=就実女子大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=12 article-no= start-page=15 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=三宝絵（上十二）と出典の文章 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田紘子 kn-aut-sei=太田 kn-aut-mei=紘子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=就実女子大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=31 article-no= start-page=229 end-page=219 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=『あひゞき』ロシア語原文と二葉亭四迷訳旧稿新稿との記号の比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田紘子 kn-aut-sei=太田 kn-aut-mei=紘子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=1 article-no= start-page=156 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Recovery from hypoxemia and Hypercapnia following noninvasive pressure support ventilation in a patient with statin-associated necrotizing myopathy: a case report en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Statin-associated necrotizing myopathy (SANM) is a rare autoimmune disorder caused by administration of statins. SANM is characterized by weakness due to necrosis and regeneration of myofibers. Here we report the first case of SANM with acute respiratory failure treated with noninvasive pressure support ventilation in addition to immunosuppressants.
Case presentation: A 59-year-old woman who had been treated with 2.5 mg/day of rosuvastatin calcium for 5 years stopped taking the drug 4 months before admission to our hospital due to elevation of creatine kinase (CK). Withdrawal of rosuvastatin for 1 month did not decrease the level of CK, and she was admitted to our hospital due to the development of muscle weakness of her neck and bilateral upper extremities. Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibodies were positive. Magnetic resonance imaging showed myositis, and muscle biopsy from the right biceps brachii muscle showed muscle fiber necrosis and regeneration without inflammatory cell infiltration, suggesting SANM. After the diagnosis, she received methylprednisolone pulse therapy (mPSL, 1 g/day × 3 days, twice) and subsequent oral prednisolone therapy (PSL, 30 mg/day for 1 month, 25 mg/day for 1 month and 22.5 mg/day for 1 month), leading to improvement of her muscle weakness. One month after the PSL tapering to 20 mg/day, her muscle weakness deteriorated with oxygen desaturation (SpO2: 93% at room air) due to hypoventilation caused by weakness of respiratory muscles. BIPAP was used for the management of acute respiratory failure in combination with IVIG (20 g/day × 5 days) followed by mPSL pulse therapy (1 g/day × 3 days), oral PSL (30 mg/day × 3 weeks, then tapered to 25 mg/day) and tacrolimus (3 mg/day). Twenty-seven days after the start of BIPAP, she was weaned from BIPAP with improvement of muscle weakness, hypoxemia and hypercapnia. After she achieved remission with improvement of muscle weakness and reduction of serum CK level to a normal level, the dose of oral prednisolone was gradually tapered to 12.5 mg/day without relapse for 3 months.
Conclusions: Our report provides new insights into the role of immunosuppressants and biphasic positive airway pressure for induction of remission in patients with SANM. en-copyright= kn-copyright= en-aut-name=YamamuraYuriko en-aut-sei=Yamamura en-aut-mei=Yuriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoYoshinori en-aut-sei=Matsumoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamamuraMasahiro en-aut-sei=Yamamura en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SadaKen-Ei en-aut-sei=Sada en-aut-mei=Ken-Ei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Center for Rheumatology, Okayama Saiseikai General Hospital kn-affil= affil-num=8 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Noninvasive pressure support ventilation kn-keyword=Noninvasive pressure support ventilation en-keyword=Statin-associated necrotizing myopathy kn-keyword=Statin-associated necrotizing myopathy en-keyword=BIPAP kn-keyword=BIPAP END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=6 article-no= start-page=1974 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200313 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prevention of Cognitive Decline in Alzheimer's Disease by Novel Antioxidative Supplements en-subtitle= kn-subtitle= en-abstract= kn-abstract=Oxidative stress plays a crucial role in Alzheimer's disease (AD) from its prodromal stage of mild cognitive impairment. There is an interplay between oxidative stress and the amyloid beta (A beta) cascade via various mechanisms including mitochondrial dysfunction, lipid peroxidation, protein oxidation, glycoxidation, deoxyribonucleotide acid damage, altered antioxidant defense, impaired amyloid clearance, inflammation and chronic cerebral hypoperfusion. Based on findings that indicate that oxidative stress plays a major role in AD, oxidative stress has been considered as a therapeutic target of AD. In spite of favorable preclinical study outcomes, previous antioxidative components, including a single antioxidative supplement such as vitamin C, vitamin E or their mixtures, did not clearly show any therapeutic effect on cognitive decline in AD. However, novel antioxidative supplements can be beneficial for AD patients. In this review, we summarize the interplay between oxidative stress and the A beta cascade, and introduce novel antioxidative supplements expected to prevent cognitive decline in AD. en-copyright= kn-copyright= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InufusaHaruhiko en-aut-sei=Inufusa en-aut-mei=Haruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=LoonAlan Foo Nyuk en-aut-sei=Loon en-aut-mei=Alan Foo Nyuk kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Division of Anti-Oxidant Research, Life Science Research Center, Gifu University kn-affil= affil-num=4 en-affil=Hovid Berhad kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Alzheimer's disease kn-keyword=Alzheimer's disease en-keyword=oxidative stress kn-keyword=oxidative stress en-keyword=supplement kn-keyword=supplement END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=2-3 article-no= start-page=131 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Eduald Bernstein, Ein Geleitwort zu Magyariens Schuld Ungarns Sühne : Revolution und Gegenrevolution in Ungarn von Oszkár Jászi kn-title=エドゥアルト・ベルンシュタイン 「オスカール・ヤーシ著『マジャルの罪，ハンガリーの償い : ハンガリーにおける革命と反革命』への序文」 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=4 article-no= start-page=165 end-page=177 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190411 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Hypervelocity collision and water-rock interaction in space preserved in the Chelyabinsk ordinary chondrite en-subtitle= kn-subtitle= en-abstract= kn-abstract=A comprehensive geochemical study of the Chelyabinsk meteorite reveals further details regarding its history of impact-related fragmentation and melting, and later aqueous alteration, during its transit toward Earth. We support an similar to 30 Ma age obtained by Ar-Ar method (Beard et al., 2014) for the impact-related melting, based on Rb-Sr isotope analyses of a melt domain. An irregularly shaped olivine with a distinct 0 isotope composition in a melt domain appears to be a fragment of a silicate-rich impactor. Hydrogen and Li concentrations and isotopic compositions, textures of Fe oxyhydroxides, and the presence of organic materials located in fractures, are together consistent with aqueous alteration, and this alteration could have pre-dated interaction with the Earth's atmosphere. As one model, we suggest that hypervelocity capture of the impact-related debris by a comet nucleus could have led to shock-wave-induced supercritical aqueous fluids dissolving the silicate, metallic, and organic matter, with later ice sublimation yielding a rocky rubble pile sampled by the meteorite. en-copyright= kn-copyright= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KunihiroTak en-aut-sei=Kunihiro en-aut-mei=Tak kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakaguchiChie en-aut-sei=Sakaguchi en-aut-mei=Chie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaRyoji en-aut-sei=Tanaka en-aut-mei=Ryoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KitagawaHiroshi en-aut-sei=Kitagawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobayashiKatsura en-aut-sei=Kobayashi en-aut-mei=Katsura kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamanakaMasahiro en-aut-sei=Yamanaka en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ShimakiYuri en-aut-sei=Shimaki en-aut-mei=Yuri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=BeboutGray E. en-aut-sei=Bebout en-aut-mei=Gray E. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MiuraHitoshi en-aut-sei=Miura en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamamotoTetsuo en-aut-sei=Yamamoto en-aut-mei=Tetsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MalkovetsVladimir en-aut-sei=Malkovets en-aut-mei=Vladimir kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=GrokhovskyVictor en-aut-sei=Grokhovsky en-aut-mei=Victor kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KorolevaOlga en-aut-sei=Koroleva en-aut-mei=Olga kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=LitasovKonstantin en-aut-sei=Litasov en-aut-mei=Konstantin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=3 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=4 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=5 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=6 en-affil=Okayama Univ, Inst Planetary Mat, Pheast Mem Lab Geochem & Cosmochem kn-affil= affil-num=7 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=8 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=9 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=10 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=11 en-affil=Graduate School of Natural Sciences, Nagoya City University kn-affil= affil-num=12 en-affil=Institute of Low Temperature Science, Hokkaido University kn-affil= affil-num=13 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=14 en-affil=Institute of Physics and Technology, Ural Federal University kn-affil= affil-num=15 en-affil=Institute of Mineralogy, Ural Branch of the Russian Academy of Sciences South-Ural State University kn-affil= affil-num=16 en-affil=V.S. Sobolev Institute of Geology and Mineralogy, Siberian Branch of the Russian Academy of Sciences kn-affil= en-keyword=ordinary chondrite kn-keyword=ordinary chondrite en-keyword=chronology kn-keyword=chronology en-keyword=geochemistry kn-keyword=geochemistry en-keyword=impact melting kn-keyword=impact melting en-keyword=asteroid kn-keyword=asteroid en-keyword=comet kn-keyword=comet END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=5 article-no= start-page=288 end-page=290 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Late presented congenital myasthenic syndrome with novel compound heterozygous CHRNE mutations mimicking seronegative myasthenia gravis en-subtitle= kn-subtitle= en-abstract= kn-abstract= We found a late presented congenital myasthenic syndrome (CMS) patient with novel CHRNE gene mutations. Although our patient has shown blepharoptosis since youth, fatigable muscle weakness began at age 71. Genetic analysis revealed novel compound heterozygous CHRNE mutations (c.1032+2T>G, c.1306_1307 delGA). His myasthenic symptoms were well managed by oral anti‐cholinesterase drug until he died at 82‐year‐old. The present case showed mild myasthenic symptoms with very late presentation and slow progression. Late presented CMS is often underdiagnosed; therefore, genetic testing is important to distinguish it from other myasthenic disease. en-copyright= kn-copyright= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsunodaKeiichiro en-aut-sei=Tsunoda en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MitsuiJun en-aut-sei=Mitsui en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TodaTatsushi en-aut-sei=Toda en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TsujiShoji en-aut-sei=Tsuji en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=anti-cholinesterase drug kn-keyword=anti-cholinesterase drug en-keyword=the CHRNE gene kn-keyword=the CHRNE gene en-keyword=congenital myasthenic syndrome kn-keyword=congenital myasthenic syndrome en-keyword=late presentation kn-keyword=late presentation en-keyword=mimicking seronegative myasthenia gravis kn-keyword=mimicking seronegative myasthenia gravis END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=5 article-no= start-page=607 end-page=609 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20181219 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Enhanced oxidative stress and the treatment by edaravone in mice model of amyotrophic lateral sclerosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= Oxidative stress is associated with the degeneration of both motor neurons and skeletal muscles in amyotrophic lateral sclerosis (ALS). A free radical scavenger edaravone has been proven as a therapeutic drug for ALS patients, but the neuroprotective mechanism for the oxidative stress of ALS has not been fully investigated. In this study, we investigated oxidative stress in ALS model mice bearing both oxidative stress sensor nuclear erythroid 2-related factor 2 (Nrf2) and G93A-human Cu/Zn superoxide dismutase (Nrf2/G93A) treated by edaravone. In vivo Nrf2 imaging analysis showed the accelerated oxidative stress both in spinal motor neurons and lower limb muscles of Nrf2/G93A mice according to disease progression in addition to the enhancement of serum oxidative stress marker dROMS. These were significantly alleviated by edaravone treatment accompanied by clinical improvements (rotarod test). The present study suggests that in vivo optical imaging of Nrf2 is useful for detecting oxidative stress in ALS, and edaravone alleviates the degeneration of both motor neurons and muscles related to oxidative stress in ALS patients. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FengTian en-aut-sei=Feng en-aut-mei=Tian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HuangYong en-aut-sei=Huang en-aut-mei=Yong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=LiuXia en-aut-sei=Liu en-aut-mei=Xia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiXiaowen en-aut-sei=Shi en-aut-mei=Xiaowen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=ALS kn-keyword=ALS en-keyword=SOD1 kn-keyword=SOD1 en-keyword=edaravone kn-keyword=edaravone en-keyword=in vivo imaging kn-keyword=in vivo imaging en-keyword=nrf2 kn-keyword=nrf2 en-keyword=oxidative stress kn-keyword=oxidative stress END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=3 article-no= start-page=146 end-page=149 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190219 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Very rare solitary primary peripheral nerve onset cytotoxic molecule-positive peripheral T-cell lymphoma (PTCL) en-subtitle= kn-subtitle= en-abstract= kn-abstract= Here we present the first report of solitary primary peripheral nerve onset cytotoxic molecule (CM)-positive peripheral T-cell lymphoma (PTCL) diagnosed after nerve biopsy. An 84-year-old female with rheumatoid arthritis (RA) complained of asymmetric severe tenderness in her upper limbs. The biopsy pathology revealed a direct invasion of CM-positive PTCL. When RA patients complain of numbness, tenderness, or weakness, lymphomatic peripheral nerve invasion should be considered. en-copyright= kn-copyright= en-aut-name=MatsumotoNamiko en-aut-sei=Matsumoto en-aut-mei=Namiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KawaharaYuko en-aut-sei=Kawahara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SakamotoMaiko en-aut-sei=Sakamoto en-aut-mei=Maiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KondouEisei en-aut-sei=Kondou en-aut-mei=Eisei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=ShibataRei en-aut-sei=Shibata en-aut-mei=Rei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Hematology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Hematology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=15 en-affil=Department of Orthopedic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=16 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=neurolymphomatosis kn-keyword=neurolymphomatosis en-keyword= neuro-oncology kn-keyword= neuro-oncology en-keyword=peripheral neuropathy kn-keyword=peripheral neuropathy en-keyword=peripheral nerve kn-keyword=peripheral nerve en-keyword=rheumatoid arthritis kn-keyword=rheumatoid arthritis en-keyword= T-cell lymphoma kn-keyword= T-cell lymphoma END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=10956 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190729 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia en-subtitle= kn-subtitle= en-abstract= kn-abstract= The therapeutic effect of in vivo direct reprogramming on ischemic stroke has not been evaluated. In the present study, a retroviral solution (1.5-2.0 × 107 /ul) of mock pMX-GFP (n = 13) or pMX-Ascl1/Sox2/NeuroD1 (ASN) (n = 14) was directly injected into the ipsilateral striatum and cortex 3 days after 30 min of transient cerebral ischemia. The reprogrammed cells first expressed neuronal progenitor marker Dcx 7 and 21 days after viral injection, then expressed mature neuronal marker NeuN. This was accompanied by morphological changes, including long processes and synapse-like structures, 49 days after viral injection. Meanwhile, therapeutic improvement was not detected both in clinical scores or infarct volume. The present study provides a future novel self-repair strategy for ischemic stroke with beneficial modifications of the inducer-suppressor balance. en-copyright= kn-copyright= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=3 article-no= start-page=132 end-page=135 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20181228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Multi‐modal combination therapy rescued a frequent ischemic stroke patient due to giant cell arteritis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ischemic stroke (IS) due to giant cell arteritis (GCA) is rare, but highly mortal. Here, we report a 72-year-old man who showed frequent IS with GCA. Initial therapy with prednisolone increased the frequency of IS, which disappeared after continuous multi-modal combination therapy with corticosteroids, immunosuppressive agents, antiplatelets, and statin. The present case was discharged with independent walk, suggesting that a multi-modal combination therapy rescued the GCA patient from frequent IS. en-copyright= kn-copyright= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsumotoNamiko en-aut-sei=Matsumoto en-aut-mei=Namiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KawaharaYuko en-aut-sei=Kawahara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=2 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=3 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=4 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=5 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=6 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=7 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=8 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=9 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=10 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=11 en-affil=Departments of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= en-keyword=combination therapy kn-keyword=combination therapy en-keyword=contrast-enhanced magnetic resonance imaging kn-keyword=contrast-enhanced magnetic resonance imaging en-keyword=frequent ischemic stroke kn-keyword=frequent ischemic stroke en-keyword=giant cell arteritis kn-keyword=giant cell arteritis en-keyword=temporal artery biopsy kn-keyword=temporal artery biopsy END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=1 article-no= start-page=327 end-page=339 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical and Pathological Benefits of Edaravone for Alzheimer's Disease with Chronic Cerebral Hypoperfusion in a Novel Mouse Model en-subtitle= kn-subtitle= en-abstract= kn-abstract= Alzheimer's disease (AD) and chronic cerebral hypoperfusion (CCH) often coexist in dementia patients in aging societies. The hallmarks of AD including amyloid-β (Aβ)/phosphorylated tau (pTau) and pathology-related events such as neural oxidative stress and neuroinflammation play critical roles in pathogenesis of AD with CCH. A large number of lessons from failures of drugs targeting a single target or pathway on this so complicated disease indicate that disease-modifying therapies targeting multiple key pathways hold potent potential in therapy of the disease. In the present study, we used a novel mouse model of AD with CCH to investigate a potential therapeutic effect of a free radical scavenger, Edaravone (EDA) on AD with CCH via examining motor and cognitive capacity, AD hallmarks, neural oxidative stress, and neuroinflammation. Compared with AD with CCH mice at 12 months of age, EDA significantly improved motor and cognitive deficits, attenuated neuronal loss, reduced Aβ/pTau accumulation, and alleviated neural oxidative stress and neuroinflammation. These findings suggest that EDA possesses clinical and pathological benefits for AD with CCH in the present mouse model and has a potential as a therapeutic agent for AD with CCH via targeting multiple key pathways of the disease pathogenesis. en-copyright= kn-copyright= en-aut-name=FengTian en-aut-sei=Feng en-aut-mei=Tian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShiXiaowen en-aut-sei=Shi en-aut-mei=Xiaowen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TsunodaKeiichiro en-aut-sei=Tsunoda en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MatsumotoNamiko en-aut-sei=Matsumoto en-aut-mei=Namiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Alzheimer’s disease kn-keyword=Alzheimer’s disease en-keyword=chronic cerebral hypoperfusion kn-keyword=chronic cerebral hypoperfusion en-keyword=edaravone kn-keyword=edaravone en-keyword=neural oxidative stress kn-keyword=neural oxidative stress en-keyword=neuroinflammation kn-keyword=neuroinflammation en-keyword=neuronal loss kn-keyword=neuronal loss END start-ver=1.4 cd-journal=joma no-vol=252 cd-vols= no-issue= article-no= start-page=107 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Lithium- and oxygen-isotope compositions of chondrule constituents in the Allende meteorite en-subtitle= kn-subtitle= en-abstract= kn-abstract= We report in situ ion-microprobe analyses of Li- and O-isotope compositions for olivine, low-Ca pyroxene, high-Ca pyroxene, and chondrule mesostasis/plagioclase in nine chondrules from the Allende CV3 chondrite. Based on their mineralogy and O-isotope compositions, we infer that the chondrule mesostasis/plagioclase and ferroan olivine rims were extensively modified or formed during metasomatic alteration and metamorphism on the Allende parent asteroid. We excluded these minerals in order to determine the correlations between Li and both O and the chemical compositions of olivines and low-Ca pyroxenes in the chondrules and their igneous rims. Based on the O-isotope composition of the olivines, nine chondrules were divided into three groups. Average Δ17O of olivines (Fo>65) in group 1 and 2 chondrules are −5.3 ± 0.4 and −6.2 ± 0.4‰, respectively. Group 3 chondrules are characterized by the presence of 16O-rich relict grains and the Δ17O of their olivines range from −23.7 to −6.2‰. In group 1 olivines, as Fa content increases, variation of δ7Li becomes smaller and δ7Li approaches the whole-rock value (2.4‰; Seitz et al., 2012), suggesting nearly complete Li-isotope equilibration. In group 2 and 3 olivines, variation of δ7Li is limited even with a significant range of Fa content. We conclude that Li-isotope compositions of olivine in group 1 chondrules were modified not by an asteroidal process but by an igneous-rim formation process, thus chondrule olivines retained Li-isotope compositions acquired in the protosolar nebula. In olivines of the group 3 chondrule PO-8, we observed a correlation between O and Li isotopes: In relict 16O-rich olivine grains with Δ17O of ∼−25 to −20‰, δ7Li ranges from −23 to −3‰; in olivine grains with Δ17O > −20‰, δ7Li is nearly constant (−8 ± 4‰). Based on the Li-isotope composition of low-Ca pyroxenes, which formed from melt during the crystallization of host chondrules and igneous rims, the existence of a gaseous reservoir with a δ7Li ∼ −11‰ is inferred. en-copyright= kn-copyright= en-aut-name=KunihiroTakuya en-aut-sei=Kunihiro en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= affil-num=3 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= en-keyword=Lithium kn-keyword=Lithium en-keyword=Oxygen kn-keyword=Oxygen en-keyword=Chondrule kn-keyword=Chondrule en-keyword=Chondrite kn-keyword=Chondrite en-keyword=Asteroid kn-keyword=Asteroid en-keyword=Allende kn-keyword=Allende en-keyword=Igneous rim kn-keyword=Igneous rim en-keyword=SIMS kn-keyword=SIMS END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=10 article-no= start-page=104310 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND:
The pathological impact of chronic cerebral hypoperfusion (CCH) on Alzheimer's disease (AD) is still poorly understood. In the present study, we investigated the role of CCH on an AD mouse model in phosphorylated tau and α-synuclein pathology, neurovascular unit, cerebrovascular remodeling, and neurovascular trophic coupling. Moreover, examined protective effect of a new antioxidant Twendee X (TwX).
METHODS:
APP23 mice were implanted to bilateral common carotid arteries stenosis with ameroid constrictors to gradually decrease the cerebral blood flow. The effects of the administration of TwX were evaluated by immunohistochemical analysis and Immunofluorescent histochemistry.
RESULTS:
The present study revealed that the expressions of phospho-tau and phospho-α-synuclein were significantly increased in the APP23 + CCH mice group as compared with wild type and APP23 mice groups (*P < .05 and ⁎⁎P < .01 versus WT; #P < .05 and ##P < .01 versus APP23). In addition, CCH significantly exacerbated MMP-9 activation relating to blood-brain barrier destruction (⁎⁎P < .01 versus WT; #P < .05, and ##P < .01 versus APP23), enhanced neurovascular remodeling, and impaired a neurovascular trophic coupling in the vascular endothelial BDNF expression of the APP23 + CCH group. TwX treatment (20 mg/kg/day, from 4.5 to 12 months) significantly reduced tau and α-synuclein pathologies, ameliorated neurovascular dysfunction compared with APP23 + CCH group.
CONCLUSIONS:
Our findings indicate that administration of a new antioxidative mixture TwX substantially reduced the above neuropathologic abnormalities, suggesting a potential therapeutic benefit of TwX for AD with CCH. en-copyright= kn-copyright= en-aut-name=LiuXia en-aut-sei=Liu en-aut-mei=Xia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShiXiaowen en-aut-sei=Shi en-aut-mei=Xiaowen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HuangYong en-aut-sei=Huang en-aut-mei=Yong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=APP23 mice kn-keyword=APP23 mice en-keyword=Alzheimer's disease kn-keyword=Alzheimer's disease en-keyword=chronic cerebral hypoperfusion kn-keyword=chronic cerebral hypoperfusion en-keyword=neurovascular dysfunction kn-keyword=neurovascular dysfunction en-keyword=phosphorylated tau kn-keyword=phosphorylated tau en-keyword=α-synuclein kn-keyword=α-synuclein END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=7 article-no= start-page=1993 end-page=2002 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND:
Multiple pathogeneses are involved in Alzheimer's disease (AD), such as amyloid-β accumulation, neuroinflammation, and oxidative stress. The pathological impact of chronic cerebral hypoperfusion on Alzheimer's disease is still poorly understood.
METHODS:
APP23 mice were implanted to bilateral common carotid arteries stenosis with ameroid constrictors for slowly progressive chronic cerebral hypoperfusion (CCH). The effects of the administration of Twendee X (TwX) were evaluated by behavioral analysis, immunohistochemical analysis, and immunofluorescent histochemistry.
RESULTS:
In the present study, chronic cerebral hypoperfusion, which is commonly found in aged Alzheimer's disease, significantly exacerbated motor dysfunction of APP23 mice from 5 months and cognitive deficit from 8 months of age, as well as neuronal loss, extracellular amyloid-β plaque and intracellular oligomer formations, and amyloid angiopathy at 12 months. Severe upregulations of oxidative markers and inflammatory markers were found in the cerebral cortex, hippocampus, and thalamus at 12 months. Twendee X treatment (20 mg/kg/d, from 4.5 to 12 months) substantially rescued the cognitive deficit and reduced the above amyloid-β pathology and neuronal loss, alleviated neuroinflammation and oxidative stress.
CONCLUSIONS:
The present findings suggested a potential therapeutic benefit of Twendee X for Alzheimer's disease with chronic cerebral hypoperfusion. en-copyright= kn-copyright= en-aut-name=LiuXia en-aut-sei=Liu en-aut-mei=Xia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShangJingwei en-aut-sei=Shang en-aut-mei=Jingwei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShiXiaowen en-aut-sei=Shi en-aut-mei=Xiaowen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HuangYong en-aut-sei=Huang en-aut-mei=Yong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=APP23 mice kn-keyword=APP23 mice en-keyword=Alzheimer's disease kn-keyword=Alzheimer's disease en-keyword=anti-inflammatory kn-keyword=anti-inflammatory en-keyword=antioxidative kn-keyword=antioxidative en-keyword=chronic cerebral hypoperfusion kn-keyword=chronic cerebral hypoperfusion END start-ver=1.4 cd-journal=joma no-vol=400 cd-vols= no-issue= article-no= start-page=145 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190515 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A unique Japanese CPEO family with a novel homozygous m.14819 T > G (p. S25A) substitution en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NomuraEmi en-aut-sei=Nomura en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TadokoroKoh en-aut-sei=Tadokoro en-aut-mei=Koh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatoKota en-aut-sei=Sato en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SasakiRyo en-aut-sei=Sasaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiYoshiaki en-aut-sei=Takahashi en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HishikawaNozomi en-aut-sei=Hishikawa en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=GotoYu-ichi en-aut-sei=Goto en-aut-mei=Yu-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AbeKoji en-aut-sei=Abe en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Medical Genome Center (MGC), Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience (NIN), National Center of Neurology and Psychiatry kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=CPEO kn-keyword=CPEO en-keyword=Homozygous kn-keyword=Homozygous en-keyword=Mitochondrial DNA kn-keyword=Mitochondrial DNA END start-ver=1.4 cd-journal=joma no-vol=334 cd-vols= no-issue= article-no= start-page=105475 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201911 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tourmaline in a Mesoarchean pelagic hydrothermal system: Implications for the habitat of early life en-subtitle= kn-subtitle= en-abstract= kn-abstract= The RNA World hypothesis requires the synthesis of RNA to allow the emergence of life on Earth. Hydrothermal systems have been proposed as potential candidates for constructing complex biomolecules. However, in order to successfully form RNA, it is necessary to stabilize ribose, a RNA carbohydrate component. Borate has been found to stabilize ribose. Therefore, boron rich hydrothermal systems are important environments concerning the origin of life on Earth.
The 3.2-Ga Dixon Island Formation of the West Pilbara Superterrane, Western Australia, is a volcano-sedimentary sequence. The Formation represents a Mesoarchean pelagic hydrothermal system, which formed adjacent to an immature island arc. Fine-grained tourmaline, in addition to biogenic carbonaceous matter and spherulitic and tubular bacteriomorphs, are found in black chert. A boron-rich environment was responsible for the formation of these deposits. To explore the implications of such a boron enriched environment on microbial activity, modes of occurrence and chemical compositions of the tourmaline were examined.
The tourmaline is schorl or dravite of the alkali tourmaline group and the boron isotope compositions range in δ11B from -7.3 to +2.6‰. The tourmaline occurs in microcrystalline quartz matrix of black chert veins that cross cut a volcanic unit and also in a bedded black chert, which overlays the volcanic unit. The volcanic unit contains highly altered zones with hydrothermal veins. The associated lithologic and stratigraphic features suggest that the black chert veins were the conduits for upward moving hydrothermal fluids, which reached the sea floor. Subsequently, the volcanic unit was covered by organic matter-rich cherty sediments that in part were fed, and/or altered, by the hydrothermal fluids.
These results suggest that the origin of boron enrichment to form Dixon Island tourmaline is not the associated sedimentary mineral assemblage, which includes diagenetic clay, low-grade metamorphic mica, and organic matter. Instead, the tourmaline was directly precipitated from hydrothermal fluid, enriched in boron. Furthermore, the hydrothermal fluids had already concentrated the boron, in the Mesoarchean pelagic system, prior to the apex of organic matter production and microbial activity. Our findings support a hypothesis that the boron-enriched hydrothermal environment aided the survival and evolution of early life. en-copyright= kn-copyright= en-aut-name=OtaTsutomu en-aut-sei=Ota en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AiharaYuhei en-aut-sei=Aihara en-aut-mei=Yuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KiyokawaShoichi en-aut-sei=Kiyokawa en-aut-mei=Shoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaRyoji en-aut-sei=Tanaka en-aut-mei=Ryoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=Department of Earth and Planetary Sciences, Kyushu University kn-affil= affil-num=3 en-affil=Department of Earth and Planetary Sciences, Kyushu University kn-affil= affil-num=4 en-affil=Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=5 en-affil=The Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University kn-affil= en-keyword=Mesoarchean kn-keyword=Mesoarchean en-keyword=Hydrothermal system kn-keyword=Hydrothermal system en-keyword=Early life kn-keyword=Early life en-keyword=Boron kn-keyword=Boron en-keyword=Tourmaline kn-keyword=Tourmaline END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=1 article-no= start-page=1 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190716 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Revolutionary Forces in Marx’s Theory and Marxism : Development? or Distortion? kn-title=変革主体論から見たマルクスの革命論とマルクス主義の革命論 : 発展？ それとも 歪曲？ en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. Diffusion of Marxism and inflation of the concept “proletariat”
The concept of “proletariat” is the central concept of Marxism. However, its content varies according to times and regions. For Marx and Engels, proletarias are workers who work in the capitalist large industries, they overthrow the rule of capitalists through the revolution and are the subjects of the construction of society in the future. Kautsky put workers in small factories and small farmers into the category of proletariat. Lenin overestimated capitalist development in Russia and included farmers without horses into proletariat. In Mao Zedong, agricultural workers, rumpen, handmade workers, peasants, clerks and peddlers are also allowed to participate in the revolution. The concept of proletariat is inflated. As the region moves away from the center of the world system, the scope of participants in the revolution has been expanded.
2. “Proletariat” in Marx’s view on social development
In Marx, proletariat is given a privileged position as a revolutionary subject in the capitalist society. In the “formulation” of historical materialism, modern bourgeois society is given a privileged position in human history. Proletariat is privileged in dual sense. In this formulation, there is no social antagonism in the future society that Marx believes. This future society should be called a “community without law and state”. It is recognized that the development of capitalist production increases the number of workers and the ordinary electoral system increases possibilities of acquiring a working-class regime. Still, Capital insists that the revolution is inevitable. Marx and Engels never abandoned “revolutionism” throughout their lives.
3. Marx’s revolutionary strategy and British working class
For Marx and Engels, England is a typical country of capitalistic development, giving models to other countries.However, the English working class in the mid-19th century was not “revolutionary”. The English labor movement during this period had been internalized under the guidance of the “labor aristocrat”. Working class was integrated as “nation”. While cooperating with the reformists politically, Marx was argueing revolutionism in scientific books. While cooperating with the reformists politically, Marx was advocating revolutionism in Capital. In modern bourgeois society, it is usual that labor classes are integrated into a system as “nation” and labor movement is to become reformistic, but Marx could not analyze this situation as a problem of upper structure of capitalism in general. In England Marx cooperated with the reformist labor movement, but could not abandon his revolutionism.
4. Reform Movement and Revolutionism: German Revisionism Controversy and Russian Party Organization Controversy
At the German Social Democratic Party, there was coexistence of reformistic practice and ideology of revolutionism. Kautsky was a personal expression of this coexistence. He adhered to revolutionism, but acknowledged that socialist consciousness was brought into labor movement from the outside historically. Bernstein claimed that revolutionism is an obstacle to workers’ reform movement. In the controversy concerning the organization of the Russian Social Democratic Party, from the standpoint of revolutionalism, Lenin argued that “external injection” is necessary because the workers’ reform movement and the revolutionary socialist movement are not directly connected. The revolutionary forces are not necessarily the product of the capitalist big industry. Those who have abilities to resist the capitalist system, they can participate in the socialist revolution through the “external injection” of the revolutionary party. It can be said that the logic of “external injection” made it possible to disseminate Marxism to the semi-periphery and periphery.
5. Conclusion
The Marxist revolution theory is understood as the theory of “revolution of developed countryies”. This is because it assumes the proletariat produced by the capitalist big industry as the revolutionary subject. In the case of Marx, its understanding is correct. However, the successful acquisition of the regime by the Marxist was in “backward countries”. It can be said that the key to solving this paradox was in the unreality of the concept of “proletariat” at the core of Marx’s revolutionism. Marx’s “proletariat” has no realities in the working class in center of modern capitalit world system （“developed capitalist countries”）. On the other hand, various anti-systemic forces were formed as a revolutionary subject entity or “proletariat” by “external injection” of the revolutionary parties in semi-periphery and periphery （the “backward areas”）. Rosa Luxemburg called as “clique management （Cliquenwirtschaft）” the regime that such forces could aquire. Under the “clique management” system, people remained in the object of governance and never became the subject. en-copyright= kn-copyright= en-aut-name=Ota Yoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学名誉教授 END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=3 article-no= start-page=25 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renners Konzeption von persönlicher nationaler Autonomie und zweidimensionaler Föderation kn-title=カール・レンナーの属人的民族的自治論と二元的連邦国家構想 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学経済学部名誉教授 END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=1 article-no= start-page=91 end-page=103 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Kautsky, Die Krisis in Österreich kn-title=カール・カウツキー「オーストリアにおける危機」 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学名誉教授 END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=3 article-no= start-page=227 end-page=237 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Kautsky, Die Revision des Programms der Sozialdemokratie in Oesterreich kn-title=カール・カウツキー「オーストリア社会民主党の綱領の修正」 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田 仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学名誉教授 END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=2 article-no= start-page=109 end-page=124 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Kautsky, Der Kampf der Nationalitäten und das Staatsrecht in Oesterreich. kn-title=カール・カウツキー「オーストリアにおける諸民族集団の闘争と国法」 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=1 article-no= start-page=117 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Kautsky, Die moderne Nationalität kn-title=カール・カウツキー「近代の民族集団」 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学名誉教授 END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=1 article-no= start-page=41 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Thoracoscopic esophagectomy was effective in a case of lower esophageal stenosis due to recurrence of achalasia after myotomy 40 years previously kn-title=40年経過した食道アカラシア術後の食道拡張・下部食道狭窄症に 対して胸腔鏡下食道亜全摘が著効した1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= When planning surgery for achalasia, it is important to plan for adequate myotomy and prevention of reflux. However, achalasia may recur if the procedure was inadequate or in patients with a long-term course. The present case is a 68-year-old woman who underwent myotomy of the lower esophageal sphincter 40 years ago, but recently reported difficulty in swallowing. Dilatation of the thoracic esophagus and stenosis of the abdominal esophagus were identified by examination, and the patient was diagnosed with recurrence of achalasia. After percutaneous endoscopic gastrostomy was performed to recover nutritional status, thoracoscopic esophagectomy was carried out. The patient'spost-operative course was uneventful and oral intake was enabled. At the time of writing, there has been no re-recurrence. There is no standard therapy for post-operative recurrence of achalasia. We believe that thoracoscopic esophagectomy for the recurrence of achalasia is a safe and minimally invasive alternative to conventional surgery. en-copyright= kn-copyright= en-aut-name=KatsuraYuki en-aut-sei=Katsura en-aut-mei=Yuki kn-aut-name=桂佑貴 kn-aut-sei=桂 kn-aut-mei=佑貴 aut-affil-num=1 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=2 ORCID= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name=田邊俊介 kn-aut-sei=田邊 kn-aut-mei=俊介 aut-affil-num=3 ORCID= en-aut-name=MaedaNaomi en-aut-sei=Maeda en-aut-mei=Naomi kn-aut-name=前田直見 kn-aut-sei=前田 kn-aut-mei=直見 aut-affil-num=4 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name=野間和広 kn-aut-sei=野間 kn-aut-mei=和広 aut-affil-num=5 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=4 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 en-keyword=食道アカラシア (achalasia) kn-keyword=食道アカラシア (achalasia) en-keyword=再手術 (reoperation) kn-keyword=再手術 (reoperation) en-keyword=食道亜全摘 (esophagectomy) kn-keyword=食道亜全摘 (esophagectomy) END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=201 end-page=205 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ectopic sebaceous glands in the esophagus that became evident over a three-year span kn-title=3 年間の内視鏡所見の変化を観察できた食道異所性皮脂腺の1 例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= A 43-year-old Japanese woman was diagnosed with ectopic sebaceous glands in the esophagus by esophagogastroduodenoscopy and biopsy. At the age of 46, typical ectopic sebaceous glands were recognized in the upper esophagus, whereas yellowish white granules were faintly observed in the lower esophagus. Esophagogastroduodenoscopy examinations were repeated when she was 47 and again at 50 years old, and the lesions in the lower esophagus had become more evident over the ensuing 3 years. Esophageal ectopic sebaceous glands are relatively infrequent, and there have been few case reports describing the progression of the endoscopic features. We also report the clinical and endoscopic features of the five similar cases with pathologically proven ectopic sebaceous glands in the esophagus. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=1 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=2 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=原田馨太 kn-aut-sei=原田 kn-aut-mei=馨太 aut-affil-num=3 ORCID= en-aut-name=KanzakiHiromitsu en-aut-sei=Kanzaki en-aut-mei=Hiromitsu kn-aut-name=神崎洋光 kn-aut-sei=神崎 kn-aut-mei=洋光 aut-affil-num=4 ORCID= en-aut-name=HoriKeisuke en-aut-sei=Hori en-aut-mei=Keisuke kn-aut-name=堀圭介 kn-aut-sei=堀 kn-aut-mei=圭介 aut-affil-num=5 ORCID= en-aut-name=KitaMasahide en-aut-sei=Kita en-aut-mei=Masahide kn-aut-name=喜多雅英 kn-aut-sei=喜多 kn-aut-mei=雅英 aut-affil-num=6 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=7 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=8 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name=田中健大 kn-aut-sei=田中 kn-aut-mei=健大 aut-affil-num=9 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=3 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=7 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=8 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=9 en-affil=Department of Pathology, Okayama University Hospital kn-affil=岡山大学病院　病理診断科 affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 en-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus） kn-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus） en-keyword=粘膜下腫瘍（submucosal tumor） kn-keyword=粘膜下腫瘍（submucosal tumor） en-keyword=食道黄色腫（esophageal xanthoma） kn-keyword=食道黄色腫（esophageal xanthoma） END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=53 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (35. Opioid-analgesic drug interactions) kn-title=薬物相互作用 (35―オピオイド鎮痛薬の薬物相互作用） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SadaHikaru en-aut-sei=Sada en-aut-mei=Hikaru kn-aut-name=佐田光 kn-aut-sei=佐田 kn-aut-mei=光 aut-affil-num=1 ORCID= en-aut-name=KajizonoMakoto en-aut-sei=Kajizono en-aut-mei=Makoto kn-aut-name=鍛治園誠 kn-aut-sei=鍛治園 kn-aut-mei=誠 aut-affil-num=2 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=北村佳久 kn-aut-sei=北村 kn-aut-mei=佳久 aut-affil-num=3 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=2 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=3 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=4 en-affil= kn-affil=岡山大学病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=21 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of mucinous adenocarcinoma of the duodenum and literature review of 16 cases reported in Japan kn-title=原発性十二指腸粘液癌の一例― 本邦報告16例の検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Primary mucinous adenocarcinoma of the duodenum is rare. Here we report a case we recently encountered, and we review 16 cases reported in Japan. An 82-year-old Japanese woman was admitted to our hospital complaining of abdominal pain and heartburn. An endoscopic examination revealed a Type 2 tumor in the descending limb of the duodenum, and endoscopically obtained specimens revealed a poorly differentiated adenocarcinoma. We performed a curative pancreatoduodenectomy with lymph node resection, and the surgical specimen revealed that the duodenum was the primary site of the mucinous adenocarcinoma. The patient is currently alive ＞ 1 year after the operation without any evidence of recurrence. Of the 16 patients reviewed, all patients had advanced tumors those depth were T3-T4. 9 patients had lymph node metastasis and 4 patients had peritoneal dissemination at the time of surgery. Since mucinous adenocarcinoma of the duodenum is often progressive cancer at a diagnosis, which is tend to have a worse prognosis than other histological types. en-copyright= kn-copyright= en-aut-name=HamanoIkumi en-aut-sei=Hamano en-aut-mei=Ikumi kn-aut-name=浜野郁美 kn-aut-sei=浜野 kn-aut-mei=郁美 aut-affil-num=1 ORCID= en-aut-name=MatsumotoYusuke en-aut-sei=Matsumoto en-aut-mei=Yusuke kn-aut-name=松本祐介 kn-aut-sei=松本 kn-aut-mei=祐介 aut-affil-num=2 ORCID= en-aut-name=EndoYoshikatsu en-aut-sei=Endo en-aut-mei=Yoshikatsu kn-aut-name=遠藤芳克 kn-aut-sei=遠藤 kn-aut-mei=芳克 aut-affil-num=3 ORCID= en-aut-name=WatanabeNaoki en-aut-sei=Watanabe en-aut-mei=Naoki kn-aut-name=渡邊直樹 kn-aut-sei=渡邊 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=KaiKyouhei en-aut-sei=Kai en-aut-mei=Kyouhei kn-aut-name=甲斐恭平 kn-aut-sei=甲斐 kn-aut-mei=恭平 aut-affil-num=5 ORCID= en-aut-name=SatoShizou en-aut-sei=Sato en-aut-mei=Shizou kn-aut-name=佐藤四三 kn-aut-sei=佐藤 kn-aut-mei=四三 aut-affil-num=6 ORCID= en-aut-name=WaniYoji en-aut-sei=Wani en-aut-mei=Yoji kn-aut-name=和仁洋治 kn-aut-sei=和仁 kn-aut-mei=洋治 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=2 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=3 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=4 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=5 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=6 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=7 en-affil= kn-affil=姫路赤十字病院　病理診断科 en-keyword=原発性十二指腸癌（primary duodenal cancer） kn-keyword=原発性十二指腸癌（primary duodenal cancer） en-keyword=粘液癌（mucinous carcinoma） kn-keyword=粘液癌（mucinous carcinoma） en-keyword=膵頭十二指腸切除（pancreatoduodenectomy） kn-keyword=膵頭十二指腸切除（pancreatoduodenectomy） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=問題解決過程におけるメタ認知の役割とその基礎科学問題解法への応用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYukio en-aut-sei=Ota en-aut-mei=Yukio kn-aut-name=太田幸雄 kn-aut-sei=太田 kn-aut-mei=幸雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=3 article-no= start-page=209 end-page=215 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hospital and clinic cooperation for the treatment of rheumatoid arthritis in Okayama Prefecture, Japan kn-title=岡山県下のクリニック・診療所におけるリウマチ診療・病診連携の実態に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: To survey the current status and problems of cooperation between clinics and hospitals in Okayama Prefecture, Japan for the treatment of rheumatoid arthritis (RA). 　Methods: We distributed a questionnaire to 300 of the 983 Okayama Prefecture clinics that had either an internal medicine or orthopedic surgery department, from December 2013 to February 2014. The questionnaire covered practice pattern for RA treatment in clinics, current status of the hospital and clinic cooperation, and acceptance of the biologic therapy. 　Results: One hundred clinics responded to the questionnaire. Seventy percent of the clinics reported making referrals to rheumatologists before the initiation of RA treatment, and half of the other 30% of the clinics administered methotrexate as the first-line treatment for RA by their own decision. Sixty-six clinics cooperated with flagship hospitals, conducting medical and laboratory examinations, providing prescriptions, and treating common diseases of patients. These clinics expected the cooperating rheumatologists to follow-up patients every 3 to 6 months and to make the diagnosis, make decisions regarding RA treatment changes, and perform surgery. Seventy-one percent of the clinics responded that cooperation with a hospital is possible even for patients who are administered biologics. As reasons for no cooperation with the flagship hospitals, clinics noted the lack of information about rheumatologists in the area and recent trends in the management of RA. 　Conclusion: The current study reported, for the first time, the actual conditions of management of RA in clinics, as well as future problems of hospital and clinic cooperation in Okayama Prefecture. en-copyright= kn-copyright= en-aut-name=SadaKen-ei en-aut-sei=Sada en-aut-mei=Ken-ei kn-aut-name=佐田憲映 kn-aut-sei=佐田 kn-aut-mei=憲映 aut-affil-num=1 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name=西田圭一郎 kn-aut-sei=西田 kn-aut-mei=圭一郎 aut-affil-num=2 ORCID= en-aut-name=YamanakaTakao en-aut-sei=Yamanaka en-aut-mei=Takao kn-aut-name=山中隆夫 kn-aut-sei=山中 kn-aut-mei=隆夫 aut-affil-num=3 ORCID= en-aut-name=MisakiKenta en-aut-sei=Misaki en-aut-mei=Kenta kn-aut-name=三崎健太 kn-aut-sei=三崎 kn-aut-mei=健太 aut-affil-num=4 ORCID= en-aut-name=WakabayashiHiroshi en-aut-sei=Wakabayashi en-aut-mei=Hiroshi kn-aut-name=若林宏 kn-aut-sei=若林 kn-aut-mei=宏 aut-affil-num=5 ORCID= en-aut-name=ShinodaJunko en-aut-sei=Shinoda en-aut-mei=Junko kn-aut-name=篠田潤子 kn-aut-sei=篠田 kn-aut-mei=潤子 aut-affil-num=6 ORCID= en-aut-name=TakagiToru en-aut-sei=Takagi en-aut-mei=Toru kn-aut-name=髙木徹 kn-aut-sei=髙木 kn-aut-mei=徹 aut-affil-num=7 ORCID= en-aut-name=YanoRyusuke en-aut-sei=Yano en-aut-mei=Ryusuke kn-aut-name=矢野隆介 kn-aut-sei=矢野 kn-aut-mei=隆介 aut-affil-num=8 ORCID= en-aut-name=NakamuraAkihiko en-aut-sei=Nakamura en-aut-mei=Akihiko kn-aut-name=中村明彦 kn-aut-sei=中村 kn-aut-mei=明彦 aut-affil-num=9 ORCID= en-aut-name=NanbaYoshifumi en-aut-sei=Nanba en-aut-mei=Yoshifumi kn-aut-name=難波良文 kn-aut-sei=難波 kn-aut-mei=良文 aut-affil-num=10 ORCID= en-aut-name=MoritaYoshitaka en-aut-sei=Morita en-aut-mei=Yoshitaka kn-aut-name=守田吉孝 kn-aut-sei=守田 kn-aut-mei=吉孝 aut-affil-num=11 ORCID= en-aut-name=KoyamaYoshinobu en-aut-sei=Koyama en-aut-mei=Yoshinobu kn-aut-name=小山芳伸 kn-aut-sei=小山 kn-aut-mei=芳伸 aut-affil-num=12 ORCID= en-aut-name=YamamotoKeiji en-aut-sei=Yamamoto en-aut-mei=Keiji kn-aut-name=山本惠嗣 kn-aut-sei=山本 kn-aut-mei=惠嗣 aut-affil-num=13 ORCID= en-aut-name=EzawaKazuhiko en-aut-sei=Ezawa en-aut-mei=Kazuhiko kn-aut-name=江澤和彦 kn-aut-sei=江澤 kn-aut-mei=和彦 aut-affil-num=14 ORCID= en-aut-name=OtaYusuke en-aut-sei=Ota en-aut-mei=Yusuke kn-aut-name=太田裕介 kn-aut-sei=太田 kn-aut-mei=裕介 aut-affil-num=15 ORCID= en-aut-name=YoshiharaYoshiki en-aut-sei=Yoshihara en-aut-mei=Yoshiki kn-aut-name=吉原由樹 kn-aut-sei=吉原 kn-aut-mei=由樹 aut-affil-num=16 ORCID= en-aut-name=MiyoshiShinya en-aut-sei=Miyoshi en-aut-mei=Shinya kn-aut-name=三好信也 kn-aut-sei=三好 kn-aut-mei=信也 aut-affil-num=17 ORCID= en-aut-name=NatsumedaMasamitsu en-aut-sei=Natsumeda en-aut-mei=Masamitsu kn-aut-name=棗田将光 kn-aut-sei=棗田 kn-aut-mei=将光 aut-affil-num=18 ORCID= en-aut-name=UsuiMasaaki en-aut-sei=Usui en-aut-mei=Masaaki kn-aut-name=臼井正明 kn-aut-sei=臼井 kn-aut-mei=正明 aut-affil-num=19 ORCID= en-aut-name=YoshinagaYasuhiko en-aut-sei=Yoshinaga en-aut-mei=Yasuhiko kn-aut-name=吉永泰彦 kn-aut-sei=吉永 kn-aut-mei=泰彦 aut-affil-num=20 ORCID= en-aut-name=HayashiTakashi en-aut-sei=Hayashi en-aut-mei=Takashi kn-aut-name=林充 kn-aut-sei=林 kn-aut-mei=充 aut-affil-num=21 ORCID= en-aut-name=YamamuraMasahiro en-aut-sei=Yamamura en-aut-mei=Masahiro kn-aut-name=山村昌弘 kn-aut-sei=山村 kn-aut-mei=昌弘 aut-affil-num=22 ORCID= en-aut-name=HashizumeHiroyuki en-aut-sei=Hashizume en-aut-mei=Hiroyuki kn-aut-name=橋詰博行 kn-aut-sei=橋詰 kn-aut-mei=博行 aut-affil-num=23 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　人体構成学 affil-num=3 en-affil= kn-affil=南岡山医療センター　リウマチ科 affil-num=4 en-affil= kn-affil=倉敷中央病院　内分泌代謝・リウマチ内科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=6 en-affil= kn-affil=岡山労災病院　整形外科 affil-num=7 en-affil= kn-affil=岡山赤十字病院　整形外科 affil-num=8 en-affil= kn-affil=矢野内科医院 affil-num=9 en-affil= kn-affil=おさふねクリニック affil-num=10 en-affil= kn-affil=川崎医科大学附属病院　整形外科 affil-num=11 en-affil= kn-affil=川崎医科大学附属病院　リウマチ・膠原病科 affil-num=12 en-affil= kn-affil=岡山赤十字病院　膠原病リウマチ内科 affil-num=13 en-affil= kn-affil=山本整形外科医院 affil-num=14 en-affil= kn-affil=倉敷スイートホスピタル　内科 affil-num=15 en-affil= kn-affil=香川労災病院　整形外科 affil-num=16 en-affil= kn-affil=倉敷成人病センター　整形外科 affil-num=17 en-affil= kn-affil=倉敷成人病センター　整形外科 affil-num=18 en-affil= kn-affil=倉敷スイートホスピタル　内科 affil-num=19 en-affil= kn-affil=岡山市民病院　整形外科 affil-num=20 en-affil= kn-affil=倉敷成人病センター　リウマチ膠原病内科 affil-num=21 en-affil= kn-affil=佐用中央病院　整形外科 affil-num=22 en-affil= kn-affil=岡山済生会総合病院　内科 affil-num=23 en-affil= kn-affil=笠岡第一病院　整形外科 en-keyword=病診連携（hospital and clinic cooperation） kn-keyword=病診連携（hospital and clinic cooperation） en-keyword=関節リウマチ（rheumatoid arthritis） kn-keyword=関節リウマチ（rheumatoid arthritis） en-keyword=生物学的製剤（biologics） kn-keyword=生物学的製剤（biologics） en-keyword=メトトレキサート（methotrexate） kn-keyword=メトトレキサート（methotrexate） END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=137 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of asymptomatic right-sided adult Bochdalek hernia presented incidentally with rectal tumor kn-title=直腸腫瘍を契機に発見された無症状の成人右側Bochdalek孔ヘルニアの１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　We encountered a patient with an adult Bochdalek hernia discovered asymptomatically. A 77-year-old Japanese woman visited a local clinic with chief complaints of melena and difficulty in defecation. Based on the results of the detailed examination in our hospital, she was diagnosed with a rectal gastrointestinal stromal tumor (GIST) with a concurrent asymptomatic adult right-sided Bochdalek hernia. Because the tumor was large, laparoscopic abdominoperineal rectal amputation was performed after systemic imatinib therapy. During the surgery, we found a right diaphragmatic defect more than 13cm in long dia., through which the right hepatic lobe, colon, and greater omentum had prolapsed into the right thoracic cavity. No visceral adhesions were noted. No hernia sac was observed. Adult Bochdalek hernia is a relatively rare condition, and only three (incidentally discovered) cases of asymptomatic Bochdalek hernia, including the present case, have been reported in Japan. Here we provide a case report for the patient, who was followed-up without hernia surgery, plus a review of the literature. en-copyright= kn-copyright= en-aut-name=KatoHiroshi en-aut-sei=Kato en-aut-mei=Hiroshi kn-aut-name=加藤大 kn-aut-sei=加藤 kn-aut-mei=大 aut-affil-num=1 ORCID= en-aut-name=OishiMasahiro en-aut-sei=Oishi en-aut-mei=Masahiro kn-aut-name=大石正博 kn-aut-sei=大石 kn-aut-mei=正博 aut-affil-num=2 ORCID= en-aut-name=KoderaMasahito en-aut-sei=Kodera en-aut-mei=Masahito kn-aut-name=小寺正人 kn-aut-sei=小寺 kn-aut-mei=正人 aut-affil-num=3 ORCID= en-aut-name=YamamuraMasao en-aut-sei=Yamamura en-aut-mei=Masao kn-aut-name=山村方夫 kn-aut-sei=山村 kn-aut-mei=方夫 aut-affil-num=4 ORCID= en-aut-name=IkedaHideaki en-aut-sei=Ikeda en-aut-mei=Hideaki kn-aut-name=池田秀明 kn-aut-sei=池田 kn-aut-mei=秀明 aut-affil-num=5 ORCID= en-aut-name=MizunoKenji en-aut-sei=Mizuno en-aut-mei=Kenji kn-aut-name=水野憲治 kn-aut-sei=水野 kn-aut-mei=憲治 aut-affil-num=6 ORCID= en-aut-name=YamashitaYutaka en-aut-sei=Yamashita en-aut-mei=Yutaka kn-aut-name=山下裕 kn-aut-sei=山下 kn-aut-mei=裕 aut-affil-num=7 ORCID= en-aut-name=SuzukiKazunori en-aut-sei=Suzuki en-aut-mei=Kazunori kn-aut-name=鈴木一則 kn-aut-sei=鈴木 kn-aut-mei=一則 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=鳥取市立病院　外科 affil-num=2 en-affil= kn-affil=鳥取市立病院　外科 affil-num=3 en-affil= kn-affil=鳥取市立病院　外科 affil-num=4 en-affil= kn-affil=鳥取市立病院　外科 affil-num=5 en-affil= kn-affil=鳥取市立病院　外科 affil-num=6 en-affil= kn-affil=鳥取市立病院　外科 affil-num=7 en-affil= kn-affil=鳥取市立病院　外科 affil-num=8 en-affil= kn-affil=鳥取生協病院　外科 en-keyword=成人Bochdalek孔ヘルニア（adult Bochdalek hernia） kn-keyword=成人Bochdalek孔ヘルニア（adult Bochdalek hernia） en-keyword=腹腔鏡下手術（laparoscopic surgery） kn-keyword=腹腔鏡下手術（laparoscopic surgery） END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=31 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Metastatic breast cancer presenting as severe anemia, platelet reduction and abnormal cells in peripheral blood kn-title=著明な貧血と血小板減少と末梢血の異常細胞で発見された転移性乳癌の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Worldwide, breast cancer accounts for 22.9% of all cancers excluding non-melanoma skin cancers in women. More than 80% of breast cancer cases are discovered when a woman discovers a lump that feels different from the rest of the breast tissue. We report the case of a 60-year-old woman who had been treated for one year at a psychiatric hospital for suspected schizophrenia, and was referred to our hospital on March 23, 2011 for consultation regarding complete blood count abnormalities: hemoglobin, 4.8g/㎗ ; Plt, 1.9×104/μl ; WBC, 12,700/μl with 18.5% abnormal cells. Computed tomography revealed an enhanced, irregular mass in her right breast as well as right axillary lymph node swelling, suggestive of breast cancer. BM biopsy confirmed the presence of abnormal, keratin-positive cells, suggesting metastasis to the bone. CA15-3 was 300U/㎖ (normal range ＜25). The patient died on April 11, 2011, post-admission day 20. We found a rare case of terminal breast cancer that presented with peripheral blood abnormality. Breast cancer in patients who do not notice breast abnormality can present with peripheral blood abnormality. en-copyright= kn-copyright= en-aut-name=OtaSeisuke en-aut-sei=Ota en-aut-mei=Seisuke kn-aut-name=太田誠介 kn-aut-sei=太田 kn-aut-mei=誠介 aut-affil-num=1 ORCID= en-aut-name=KasaharaAkinori en-aut-sei=Kasahara en-aut-mei=Akinori kn-aut-name=笠原明宣 kn-aut-sei=笠原 kn-aut-mei=明宣 aut-affil-num=2 ORCID= en-aut-name=MizunoShoma en-aut-sei=Mizuno en-aut-mei=Shoma kn-aut-name=水野翔馬 kn-aut-sei=水野 kn-aut-mei=翔馬 aut-affil-num=3 ORCID= en-aut-name=FukatsuHaruka en-aut-sei=Fukatsu en-aut-mei=Haruka kn-aut-name=深津遥香 kn-aut-sei=深津 kn-aut-mei=遥香 aut-affil-num=4 ORCID= en-aut-name=KinoshitaOsamu en-aut-sei=Kinoshita en-aut-mei=Osamu kn-aut-name=木下修 kn-aut-sei=木下 kn-aut-mei=修 aut-affil-num=5 ORCID= en-aut-name=NoguchiToshio en-aut-sei=Noguchi en-aut-mei=Toshio kn-aut-name=野口敏生 kn-aut-sei=野口 kn-aut-mei=敏生 aut-affil-num=6 ORCID= en-aut-name=KishimotoNobuyasu en-aut-sei=Kishimoto en-aut-mei=Nobuyasu kn-aut-name=岸本信康 kn-aut-sei=岸本 kn-aut-mei=信康 aut-affil-num=7 ORCID= en-aut-name=MatsumuraTadashi en-aut-sei=Matsumura en-aut-mei=Tadashi kn-aut-name=松村正 kn-aut-sei=松村 kn-aut-mei=正 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=姫路聖マリア病院　内科 affil-num=2 en-affil= kn-affil=姫路聖マリア病院　内科 affil-num=3 en-affil= kn-affil=姫路聖マリア病院　呼吸器内科 affil-num=4 en-affil= kn-affil=姫路聖マリア病院　内科 affil-num=5 en-affil= kn-affil=姫路聖マリア病院　内科 affil-num=6 en-affil= kn-affil=姫路聖マリア病院　内科 affil-num=7 en-affil= kn-affil=姫路聖マリア病院　呼吸器内科 affil-num=8 en-affil= kn-affil=姫路聖マリア病院　内科 en-keyword=乳癌（breast cancer） kn-keyword=乳癌（breast cancer） en-keyword=初発症状（initial symptom） kn-keyword=初発症状（initial symptom） en-keyword=貧血（anemia） kn-keyword=貧血（anemia） en-keyword=骨髄転移（bone marrow metastasis） kn-keyword=骨髄転移（bone marrow metastasis） END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=235 end-page=238 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two operated cases of mesenteric abscess caused by penetration of the transverse colon associated with a diverticulum kn-title=横行結腸憩室穿通による腸間膜膿瘍に対して手術を施行した２症例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We encountered 2 cases of penetration of fecal matter through a diverticulum of the transverse colon, which is a rare disease. Case 1 was a 33-year-old man who was examined in the clinic with a complaint of epigastralgia. Tenderness and muscular defense were found in the upper abdomen. On abdominal CT examination, wall thickening and increased fat concentration were seen in the transverse colon. He was diagnosed with peritonitis and underwent emergency surgery. On laparotomy, a tumor mass was found in the transverse colon close to the liver curvature. The patient was diagnosed with mesenteric abscess due to penetration of fecal matter through a diverticulum of the transverse colon. Right hemicolectomy was carried out. Case 2 was a 43-year-old woman who was examined in the clinic with a complaint of right lower abdominal pain. Muscular defense and rebound tenderness were found in the lower abdomen. On abdominal CT examination, abscess formation was seen in the right lower abdomen. She was diagnosed with peritonitis and underwent emergency surgery. On laparotomy, a tumor mass was found in the transverse colon. The patient was diagnosed with mesenteric abscess due to penetration of the transverse colon associated with a diverticulum. Partial removal of the transverse colon was carried out. en-copyright= kn-copyright= en-aut-name=MaedaNaoaki en-aut-sei=Maeda en-aut-mei=Naoaki kn-aut-name=前田直見 kn-aut-sei=前田 kn-aut-mei=直見 aut-affil-num=1 ORCID= en-aut-name=KondoHidenori en-aut-sei=Kondo en-aut-mei=Hidenori kn-aut-name=近藤秀則 kn-aut-sei=近藤 kn-aut-mei=秀則 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=医療法人敬和会近藤病院　外科 affil-num=2 en-affil= kn-affil=医療法人敬和会近藤病院　外科 en-keyword=横行結腸憩室（transverse colon diverticulum） kn-keyword=横行結腸憩室（transverse colon diverticulum） en-keyword=腸間膜内穿通（mesenteric penetration） kn-keyword=腸間膜内穿通（mesenteric penetration） en-keyword=腸間膜膿瘍（mesenteric abscess） kn-keyword=腸間膜膿瘍（mesenteric abscess） END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=2 article-no= start-page=59 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on the Expiration of the Calculation upon Mergers of Local Tax Allocation - Do Intergovernmental Fiscal Relations Keep Working? - kn-title=地方交付税の合併算定替え終了が市町村に及ぼす影響 ―財源調整機能は維持されるか― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYuji en-aut-sei=Ota en-aut-mei=Yuji kn-aut-name=太田裕二 kn-aut-sei=太田 kn-aut-mei=裕二 aut-affil-num=1 ORCID= en-aut-name=HiraoMasaki en-aut-sei=Hirao en-aut-mei=Masaki kn-aut-name=平野正樹 kn-aut-sei=平野 kn-aut-mei=正樹 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3-4 article-no= start-page=197 end-page=202 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preventive effect of the proteinaceous inhibitor of ethylene synthesis on berry drop of Kyohō grape (II) kn-title=エチレン生成阻害蛋白によるブドウ巨峰の脱粒防止の効果について(II) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SakaiS. en-aut-sei=Sakai en-aut-mei=S. kn-aut-name=酒井慎吾 kn-aut-sei=酒井 kn-aut-mei=慎吾 aut-affil-num=1 ORCID= en-aut-name=BabaI. en-aut-sei=Baba en-aut-mei=I. kn-aut-name=馬場赳 kn-aut-sei=馬場 kn-aut-mei=赳 aut-affil-num=2 ORCID= en-aut-name=OtaY. en-aut-sei=Ota en-aut-mei=Y. kn-aut-name=太田保夫 kn-aut-sei=太田 kn-aut-mei=保夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=4 article-no= start-page=217 end-page=223 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=197703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preventive effect of the proteinaceous inhibitor of ethylene synthesis on berry drop of Kyoho grape kn-title=エチレン生成阻害蛋白によるブドウ巨峰の脱粒防止の効果について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SakaiS. en-aut-sei=Sakai en-aut-mei=S. kn-aut-name=酒井慎吾 kn-aut-sei=酒井 kn-aut-mei=慎吾 aut-affil-num=1 ORCID= en-aut-name=BabaI. en-aut-sei=Baba en-aut-mei=I. kn-aut-name=馬場赳 kn-aut-sei=馬場 kn-aut-mei=赳 aut-affil-num=2 ORCID= en-aut-name=OtaY. en-aut-sei=Ota en-aut-mei=Y. kn-aut-name=太田保夫 kn-aut-sei=太田 kn-aut-mei=保夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=152 end-page=161 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=School Health Organization at Junior High School Attached to the School Education,Okayama University kn-title=附属中学校における学校保健委員会の取組み―養護実習への活用を視野に入れて― en-subtitle= kn-subtitle= en-abstract= kn-abstract=　岡山大学教育学部附属中学校における学校保健委員会の取組み，および学校保健委員会の資料の養護実習への活用について報告する。附属中学校の学校保健委員会は，①学校保健活動の全体像が理解されること，②課題が明確になる資料を工夫すること，③関係者の共通理解が図られること，の3つの視点から取組まれており，このことが日々の学校保健活動に対する有効な施策を協議するために重要であった。学校保健委員会の資料は同時に，養護実習において学生が学校保健活動を理解するための教材として活用できる。 en-copyright= kn-copyright= en-aut-name=OtaYasuko en-aut-sei=Ota en-aut-mei=Yasuko kn-aut-name=太田泰子 kn-aut-sei=太田 kn-aut-mei=泰子 aut-affil-num=1 ORCID= en-aut-name=KamimuraHiroko en-aut-sei=Kamimura en-aut-mei=Hiroko kn-aut-name=上村弘子 kn-aut-sei=上村 kn-aut-mei=弘子 aut-affil-num=2 ORCID= en-aut-name=MunakataHokuma en-aut-sei=Munakata en-aut-mei=Hokuma kn-aut-name=棟方百熊 kn-aut-sei=棟方 kn-aut-mei=百熊 aut-affil-num=3 ORCID= en-aut-name=MiyamotoKayoko en-aut-sei=Miyamoto en-aut-mei=Kayoko kn-aut-name=宮本香代子 kn-aut-sei=宮本 kn-aut-mei=香代子 aut-affil-num=4 ORCID= en-aut-name=MondenShinichiro en-aut-sei=Monden en-aut-mei=Shinichiro kn-aut-name=門田新一郎 kn-aut-sei=門田 kn-aut-mei=新一郎 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学教育学部附属中学校 affil-num=2 en-affil= kn-affil=岡山大学大学院教育学研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院教育学研究科 affil-num=4 en-affil= kn-affil=岡山大学大学院教育学研究科 affil-num=5 en-affil= kn-affil=岡山大学大学院教育学研究科 en-keyword=学校保健委員会 kn-keyword=学校保健委員会 en-keyword=養護実習 kn-keyword=養護実習 en-keyword=附属中学校 kn-keyword=附属中学校 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=5 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Computational fluid dynamics of carotid arteries after carotid endarterectomy or carotid artery stenting based on postoperative patient-specific medical data kn-title=頚動脈内膜剥離術あるいは頚動脈ステント留置術施行後の患者固有データに基づく頚動脈血流の流体力学的シミュレーション en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HayaseHitoshi en-aut-sei=Hayase en-aut-mei=Hitoshi kn-aut-name=早瀬仁志 kn-aut-sei=早瀬 kn-aut-mei=仁志 aut-affil-num=1 ORCID= en-aut-name=TokunagaKoji en-aut-sei=Tokunaga en-aut-mei=Koji kn-aut-name=徳永浩司 kn-aut-sei=徳永 kn-aut-mei=浩司 aut-affil-num=2 ORCID= en-aut-name=NakayamaToshio en-aut-sei=Nakayama en-aut-mei=Toshio kn-aut-name=中山敏男 kn-aut-sei=中山 kn-aut-mei=敏男 aut-affil-num=3 ORCID= en-aut-name=SugiuKenji en-aut-sei=Sugiu en-aut-mei=Kenji kn-aut-name=杉生憲志 kn-aut-sei=杉生 kn-aut-mei=憲志 aut-affil-num=4 ORCID= en-aut-name=NishidaAyumi en-aut-sei=Nishida en-aut-mei=Ayumi kn-aut-name=西田あゆみ kn-aut-sei=西田 kn-aut-mei=あゆみ aut-affil-num=5 ORCID= en-aut-name=ArimitsuSeiji en-aut-sei=Arimitsu en-aut-mei=Seiji kn-aut-name=有光帥二 kn-aut-sei=有光 kn-aut-mei=帥二 aut-affil-num=6 ORCID= en-aut-name=HishikawaTomohito en-aut-sei=Hishikawa en-aut-mei=Tomohito kn-aut-name=菱川朋人 kn-aut-sei=菱川 kn-aut-mei=朋人 aut-affil-num=7 ORCID= en-aut-name=OnoShigeki en-aut-sei=Ono en-aut-mei=Shigeki kn-aut-name=小野成紀 kn-aut-sei=小野 kn-aut-mei=成紀 aut-affil-num=8 ORCID= en-aut-name=OhtaMakoto en-aut-sei=Ohta en-aut-mei=Makoto kn-aut-name=太田信 kn-aut-sei=太田 kn-aut-mei=信 aut-affil-num=9 ORCID= en-aut-name=DateIsao en-aut-sei=Date en-aut-mei=Isao kn-aut-name=伊達勲 kn-aut-sei=伊達 kn-aut-mei=勲 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 affil-num=3 en-affil= kn-affil=東北大学流体科学研究所　知能流システム研究部門生体流動研究分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 affil-num=9 en-affil= kn-affil=東北大学流体科学研究所　知能流システム研究部門生体流動研究分野 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 en-keyword=carotid artery stenosis kn-keyword=carotid artery stenosis en-keyword=carotid artery stenting kn-keyword=carotid artery stenting en-keyword=carotid endarterectomy kn-keyword=carotid endarterectomy en-keyword=computational fluid dynamics kn-keyword=computational fluid dynamics en-keyword=wall shear stress kn-keyword=wall shear stress END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=3 article-no= start-page=223 end-page=229 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Electronic medical records and medical insurance kn-title=保険診療と電子カルテ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=GochiAkira en-aut-sei=Gochi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　経営戦略支援部 en-keyword=保険診療 kn-keyword=保険診療 en-keyword=電子カルテ kn-keyword=電子カルテ en-keyword=特定共同指導 kn-keyword=特定共同指導 END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=4 article-no= start-page=482 end-page=487 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=加齢と運動習慣が換気性閾値に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三浦孝仁 kn-aut-sei=三浦 kn-aut-mei=孝仁 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高橋香代 kn-aut-sei=高橋 kn-aut-mei=香代 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=鈴木久雄 kn-aut-sei=鈴木 kn-aut-mei=久雄 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平田敏彦 kn-aut-sei=平田 kn-aut-mei=敏彦 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=吉田総一郎 kn-aut-sei=吉田 kn-aut-mei=総一郎 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=吉良尚平 kn-aut-sei=吉良 kn-aut-mei=尚平 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山県立短期大学 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 affil-num=7 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=112 end-page=119 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Results and Issues in Student Teaching Program for Freshman at Okayama University on 2011 kn-title=1年次教育実習プログラムの成果と課題の検討―平成23年度教育実習Ⅰ受講生アンケートの結果から― en-subtitle= kn-subtitle= en-abstract= kn-abstract=本研究の目的は，岡山大学教育学部における1年次の教育実習プログラムの成果と課題の検討であった。そのため，平成23年度の教育実習Ⅰ受講生294名を対象に実習後に調査を行った。その結果，（１）教育実践力を構成する4つの力や附属学校園における実習目的の多くが達成されている，（２）4つの力のうち「コーディネート力」「生徒指導力」の達成度が特に高く，「学習指導力」の学校種ごとの学習指導の特徴や違いを説明することは達成度が低い，（３）附属学校園が掲げる目的のうち，観察して学ぶことの達成度が高いが，実際に児童生徒 と関わって学ぶことの達成度は低い傾向である，（４）実習中の実習生の取り組みに関しては，授業観察において事実を観察，記録することは取り組めているが，解釈的な授業観察や，協議会での発言は十分取り組めていない，の4点が主に示唆され，実習Ⅰの課題や不安に対する学生の自由記述と併せて結果が考察された。 en-copyright= kn-copyright= en-aut-name=MishimaTomotaka en-aut-sei=Mishima en-aut-mei=Tomotaka kn-aut-name=三島知剛 kn-aut-sei=三島 kn-aut-mei=知剛 aut-affil-num=1 ORCID= en-aut-name=YamasakiMitsuhiro en-aut-sei=Yamasaki en-aut-mei=Mitsuhiro kn-aut-name=山﨑光洋 kn-aut-sei=山﨑 kn-aut-mei=光洋 aut-affil-num=2 ORCID= en-aut-name=TakahataHiroshi en-aut-sei=Takahata en-aut-mei=Hiroshi kn-aut-name=髙旗浩志 kn-aut-sei=髙旗 kn-aut-mei=浩志 aut-affil-num=3 ORCID= en-aut-name=SekineMasami en-aut-sei=Sekine en-aut-mei=Masami kn-aut-name=関根正美 kn-aut-sei=関根 kn-aut-mei=正美 aut-affil-num=4 ORCID= en-aut-name=WatanabeMasakatsu en-aut-sei=Watanabe en-aut-mei=Masakatsu kn-aut-name=渡邊将勝 kn-aut-sei=渡邊 kn-aut-mei=将勝 aut-affil-num=5 ORCID= en-aut-name=AkazakiTetsuya en-aut-sei=Akazaki en-aut-mei=Tetsuya kn-aut-name=赤﨑哲也 kn-aut-sei=赤﨑 kn-aut-mei=哲也 aut-affil-num=6 ORCID= en-aut-name=ShibataYasuko en-aut-sei=Shibata en-aut-mei=Yasuko kn-aut-name=柴田靖子 kn-aut-sei=柴田 kn-aut-mei=靖子 aut-affil-num=7 ORCID= en-aut-name=KishiAkiko en-aut-sei=Kishi en-aut-mei=Akiko kn-aut-name=岸晶子 kn-aut-sei=岸 kn-aut-mei=晶子 aut-affil-num=8 ORCID= en-aut-name=OhtaYasuko en-aut-sei=Ohta en-aut-mei=Yasuko kn-aut-name=太田泰子 kn-aut-sei=太田 kn-aut-mei=泰子 aut-affil-num=9 ORCID= en-aut-name=KagaMasaru en-aut-sei=Kaga en-aut-mei=Masaru kn-aut-name=加賀勝 kn-aut-sei=加賀 kn-aut-mei=勝 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学教師教育開発センター affil-num=2 en-affil= kn-affil=岡山大学教師教育開発センター affil-num=3 en-affil= kn-affil=岡山大学教師教育開発センター affil-num=4 en-affil= kn-affil=岡山大学大学院教育学研究科 affil-num=5 en-affil= kn-affil=岡山大学教育学部附属小学校 affil-num=6 en-affil= kn-affil=岡山大学教育学部附属中学校 affil-num=7 en-affil= kn-affil=岡山大学教育学部附属特別支援学校 affil-num=8 en-affil= kn-affil=岡山大学教育学部附属幼稚園 affil-num=9 en-affil= kn-affil=岡山大学教育学部附属中学校 affil-num=10 en-affil= kn-affil=岡山大学大学院教育学研究科・岡山大学教師教育開発センター en-keyword=教育実習 kn-keyword=教育実習 en-keyword=教職志望学生 kn-keyword=教職志望学生 en-keyword=学部1年生 kn-keyword=学部1年生 en-keyword=教員養成 kn-keyword=教員養成 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=63 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pathological complete response of advanced gastric cancer with pyloric stenosis to neoadjuvant S-1/CDDP chemotherapy: A case report kn-title=S-1/CDDP術前化学療法により組織学的CRが得られた幽門狭窄合併進行胃癌の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 59-year-old man with epigastric discomfort and anorexia was referred to our hospital. Endoscopy revealed a type 3 advanced gastric cancer with pyloric stenosis diagnosed as a poorly differentiated adenocarcinoma in the biopsy specimens. A gastrojejunal bypass operation was performed because of direct invasion to the pancreas. The patient was treated by three courses of neoadjuvant chemotherapy with S-1/CDDP. Follow-up abdominal CT scan revealed that the primary tumor had become smaller, suggesting that a partial response had been achieved. Distal gastrectomy with D2 lymphadenectomy was performed. The histopathological examination showed no residual cancer cells in the primary lesion or dissected lymph nodes. Final chemotherapy efficacy was evaluated as Grade 3. The patient was treated with S-1 for one year after the gastrectomy and lymphadenectomy and has been followed up for 18 months without evidence of recurrence. en-copyright= kn-copyright= en-aut-name=NishizakiMasahiko en-aut-sei=Nishizaki en-aut-mei=Masahiko kn-aut-name=西崎正彦 kn-aut-sei=西崎 kn-aut-mei=正彦 aut-affil-num=1 ORCID= en-aut-name=FujiwaraYasuhiro en-aut-sei=Fujiwara en-aut-mei=Yasuhiro kn-aut-name=藤原康宏 kn-aut-sei=藤原 kn-aut-mei=康宏 aut-affil-num=2 ORCID= en-aut-name=ChoudaYasuhiro en-aut-sei=Chouda en-aut-mei=Yasuhiro kn-aut-name=丁田泰宏 kn-aut-sei=丁田 kn-aut-mei=泰宏 aut-affil-num=3 ORCID= en-aut-name=KanazawaTakashi en-aut-sei=Kanazawa en-aut-mei=Takashi kn-aut-name=金澤卓 kn-aut-sei=金澤 kn-aut-mei=卓 aut-affil-num=4 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=二宮基樹 kn-aut-sei=二宮 kn-aut-mei=基樹 aut-affil-num=5 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 en-keyword=幽門狭窄 (pyloric stenosis) kn-keyword=幽門狭窄 (pyloric stenosis) en-keyword=進行胃癌 (advanced gastric cancer) kn-keyword=進行胃癌 (advanced gastric cancer) en-keyword=S-1/CDDP kn-keyword=S-1/CDDP en-keyword=術前化学療法 (neoadjuvant chemotherapy) kn-keyword=術前化学療法 (neoadjuvant chemotherapy) en-keyword=組織学的CR (pathological CR) kn-keyword=組織学的CR (pathological CR) END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ER-style emergency medical systems kn-title=ER型救急医療について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IchibaShingo en-aut-sei=Ichiba en-aut-mei=Shingo kn-aut-name=市場晋吾 kn-aut-sei=市場 kn-aut-mei=晋吾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療学 en-keyword=救急医療 kn-keyword=救急医療 en-keyword=初期診療 kn-keyword=初期診療 en-keyword=地域医療 kn-keyword=地域医療 en-keyword=トリアージ kn-keyword=トリアージ en-keyword=emergency department kn-keyword=emergency department END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue=344 article-no= start-page=855 end-page=876 dt-received= dt-revised= dt-accepted= dt-pub-year=1918 dt-pub=19180930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=南部フ井リッピン群島ダバヲ方面ニ於ケル脚氣ニ就キテ (第一回報告) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=天川保 kn-aut-sei=天川 kn-aut-mei=保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=フ井リッピン群島ダバヲ太田興業株式會社附屬O. D. C.病院 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=11 article-no= start-page=2991 end-page=2994 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19351130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Über das Schicksal des Trichlorbuthylalkohols (Chloretons) im Tierkörper kn-title=Trichlorbuthylalkohol (Chloreton)ノ動物體内ニ於ケル運命ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seit dem Chloralhydratversuch von Mering und Musculus war festgestellt worden, dasz einige Halogenderivate der aliphatischen Aldehyden und Alkohole im Tierorganismus gepaart mit der Glukuronsäure im Harne ausgeschieden werden. Schon im Jahre 1884 nahm E. Külz auf Grund von Experimenten an, dasz der den Tieren verabreichte Trichlorbuthylalkohol gepaart mit Glukuronsäure im Harne erscheint, aus welchem er aber die gepaarte Säure nicht isolieren konnte. Durch dieses Experiment hat Verfasser die genannte Säure als Beriumsalz gewonnen, das durch Reaktionen sowie Bariumbestimmung und Elementaranalyse als solches festgestellt und dessen spezifische Drehung auch festgelegt wurde. en-copyright= kn-copyright= en-aut-name=OhtaTokujiro en-aut-sei=Ohta en-aut-mei=Tokujiro kn-aut-name=太田徳次郎 kn-aut-sei=太田 kn-aut-mei=徳次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=11 article-no= start-page=2985 end-page=2990 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19351130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Über die Schwangerschaftsreaktion nach Zondek-Aschheim bei krimineller Fruchtabtreibung kn-title=早流産ニ於ケルZondek=Aschheim氏妊娠診斷法ノ範圍 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Um festzustellen, inwieweit der puerperale Harn nach frühzeitiger Fruchtabtreibung die Schwangerschaftsreaktion nach Zondek-Aschheim positiv ergibt, beschäftigte sich Verfasser mit einer Reihe von Versuchen, in denen der Harn von Frauen untersucht wurde, die sich in jedem Schwangerschaftsmonate unter klinischer Indikation künstlicher Unterbrechung unterwarfen. Die Ergebnisse lassen sich, wie Folgt, zusammenfassen. 1) Verfasser untersuchte den Harn von im 2. bis 7. Schwangerschaftsmonate operierten Frauen. 2) Mit dem Harn des 2. bis 7. Schwangerschaftsmonates fiel diese Reaktion 4 Tage nach der Fruchtabtreibung positiv aus, aber 5 Tage nach dieser war das Resultat inkonstant; allerdings erlebte Verfasser auch eiuen Fall bei dem der Harn am 9. Tage diese Reaktion positiv ergab. 3) Ein Einfluss des Schwangerschaftsmonates auf diese Reaktion konnte nicht nachgewiesen werden. 4) Auf Grund genannter Resultate ist Verfasser der Meinung, dasz diese Reaktion anschliessend an sonstige klinische Befunden bis zum 9. Tage nach der Fruchtabtribung gerichtärztlich von grosser Bedeutung ist. en-copyright= kn-copyright= en-aut-name=OhtaTokujiro en-aut-sei=Ohta en-aut-mei=Tokujiro kn-aut-name=太田徳次郎 kn-aut-sei=太田 kn-aut-mei=徳次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue=3 article-no= start-page=442 end-page=463 dt-received= dt-revised= dt-accepted= dt-pub-year=1936 dt-pub=19360331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchung über den Stickstoffwechsel bei Kaninchenschistosomiasis japonica kn-title=實験的日本住血吸蟲病家兎ニ於ケル窒素新陳代謝ニ關スル研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Da die zirrhotische Veränderung der Leber des durch Schistosommn japonicum infzierten Organismus sowohl auf die mechanische wie auf die Giftwirkung der Parasiten zurückzufülnen ist, so ist es nicht uninteressant, die Einflüsse der Parasiten auf den Stoffwechsel des Organismus zu untersuchen. Unter diesem Thema haben Verfasser einige Experimente mit Kanincheu ausgeführt, deren Resultate hier folgendermassen zusammengefasst werden können: 1) In dieser Untersuchung wurde eine Reihe von Kaninchen experimentell durch Schistosomum japonicum infiziert und der Harn des erkrankten Kaninchens chemisch erforscht. 2) Im Aufangs- oder leichten Stadium der Schistosomiasis japonica bei Kaninchen zeigt der Harn kaum irgendeine erkennbare Veränderung. 3) Beim schweren oder späteren Stadium kommen bei erkrankten Kaninchen verschiedene Harnveränderungen zum Vorschein, aus denen wir auf gestörten Stoffwechsel achliessen dürfen. a) Das Körpergewicht und die Harnmenge nehmen ab, der Harn wird allmählich saner, sein spezifisches gewicht erhöht sich und im Harn tritt Grallenfarbstoff auf. b) Das vermehrte Harnammoniak kann sowohl auf die überschüssige Säureproduktion wie auf die stärlkere Zersetzung des Körpereiweisses des erkrankteu Organismus zurückzuführen sein. c) Aus der erhöhten Aminosäureausscheidung darf man auch auf den Zerfall des Körpereiweisses schliessen. d) Der vermehrte Harnpurinkörper, die verminderte Harnsäure und das besonders verringerte Harnallantoin, d. i. die vorhandene Purinstoffwechselstörung lässt eine Schädigung der Leberfunktion des erkrankten Organismus annehmen, wean man das Auftreten des Gallenfarbstoffes im Harne und die pathologisch-anatomische Veränderung der Leber dabei in Erwägung zieht. en-copyright= kn-copyright= en-aut-name=OhtaTokujiro en-aut-sei=Ohta en-aut-mei=Tokujiro kn-aut-name=太田徳次郎 kn-aut-sei=太田 kn-aut-mei=徳次郎 aut-affil-num=1 ORCID= en-aut-name=NishizakiBuikazu en-aut-sei=Nishizaki en-aut-mei=Buikazu kn-aut-name=西崎武亥一 kn-aut-sei=西崎 kn-aut-mei=武亥一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 affil-num=2 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=9 article-no= start-page=1893 end-page=1936 dt-received= dt-revised= dt-accepted= dt-pub-year=1938 dt-pub=19380930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Über den Einfluss des Sonnenlichtes auf die Leichenzersetzung kn-title=太陽光線ノ死體分解ニ及ボス影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Es ist selbstverständlich, dass sich der Reststickstoff, der Zucker, das Glykogen und die Milchsäure in der Leichenleber sowie im Leichenmuskel mit dem Alter der Leiche quantitativ verandern. Solange die Bestimmung einzelner Substanzen möglich ist, nimmt der Reststickstoff mit dem Leichenalter zu, was mit den Daten von Ido, Momonoi u. Nisizaki gut ubereinstimmt, das Glykogen aber ab; Zucker und Milchsäure vermehren sich allmahlich, um dann zu wieder abzunehmen. Die Vermehrung oder Verminderung der genannten Substanzen trat bei der vom Sonnenlicht bestrahlten Leiche weniger auffallend in Erscheinung als bei der an dunkler Stelle aufbewahrten, wobei die Temperatur und die sonstige Umständen in der Umgebung beider Leichen fast gleich gehalten wurden. In den makroskopischen Befunden beider gennanten Leichen liess sich auch der Unterschied bemerken, dass sich bei der bestrahlten Leiche die Faulnis in geringerem Masse entwickelte. Der chemische sowie makroskopische Unterschied zwischen beiden Leichen ist sicherlich auf die Wirkung des Sonnenlichtes zurückzuführen, besonders auf die Wirkung der ultravioletten Strahlen auf die Fermente und die Bakterien in den Leichenorganen und -geweben. en-copyright= kn-copyright= en-aut-name=OhtaTokujiro en-aut-sei=Ohta en-aut-mei=Tokujiro kn-aut-name=太田徳次郎 kn-aut-sei=太田 kn-aut-mei=徳次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=1 article-no= start-page=39 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Investigation of laparoscopic therapy in 56 cases of duodenal ulcer perforation kn-title=成人先天性胆道拡張症の6例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report six patients with adult congenital biliary dilatation treated by surgery. Of the six cases, five were female and the patients' age at diagnosis ranged from 19 to 51 years old. By Todani's classification for bile duct dilatation, three were categorized as Ⅰa, one as Ⅰb, and two as Ⅳa. All six cases had anomalous arrangement of the pancreatobiliary duct. Resection of the cystic portion and hepaticojejunostomy (Roux-Y) were performed in all. After surgery, one patient classified as Ⅰa and one as Ⅳa had complications of cholangitis and intrahepatic stones. We removed the stones by the percutaneous transhepatic route with dilatation of the stenotic anastomosis, but cholangitis recurred in the Ⅳa patient. Although surgical resection of the cystic portion and reconstruction of biliary tract is considered to be a standard treatment for adult congenital biliary dilatation, this Ⅳa case had complications after surgical treatment. Thus short-term follow-up is necessary to prevent or diagnose stenotic anastomosis following the operation. en-copyright= kn-copyright= en-aut-name=TakashimaHirotoshi en-aut-sei=Takashima en-aut-mei=Hirotoshi kn-aut-name=高嶌寛年 kn-aut-sei=高嶌 kn-aut-mei=寛年 aut-affil-num=1 ORCID= en-aut-name=SasakiAkira en-aut-sei=Sasaki en-aut-mei=Akira kn-aut-name=佐々木明 kn-aut-sei=佐々木 kn-aut-mei=明 aut-affil-num=2 ORCID= en-aut-name=SasakiKaoru en-aut-sei=Sasaki en-aut-mei=Kaoru kn-aut-name=佐々木薫 kn-aut-sei=佐々木 kn-aut-mei=薫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=医療法人社団曙会　佐々木外科病院 affil-num=2 en-affil= kn-affil=医療法人社団曙会　佐々木外科病院 affil-num=3 en-affil= kn-affil=医療法人社団曙会　佐々木外科病院 en-keyword=先天性胆道拡張症 (congenital biliary dilatation) kn-keyword=先天性胆道拡張症 (congenital biliary dilatation) en-keyword=膵胆管合流異常 (anomalous arrangement of pancreaticobiliary ducts) kn-keyword=膵胆管合流異常 (anomalous arrangement of pancreaticobiliary ducts) END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=4 article-no= start-page=119 end-page=130 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories （XVI） kn-title=マルクス主義理論史研究の課題（XVI）―星野中のマルクス主義研究― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=11-12 article-no= start-page=689 end-page=696 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19641230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cytologial Classification of Leukemias kn-title=白血病の細胞学的分類 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the attempts to classify leukemic cells it is often difficult to identify cells solely with fixed and stained blood smears as in acute leukemia where the percentage of blast cells is high. In such instances, however, it is generally possible to distinguish most cells when vital observations are carried out in conjunction with cytochemical methods, fluorescence micro scopy, as well as electronmicroscopy. The results of these observations have been briefly summarized. The characteristic findings of lymphoblasts, myeloblasts, and monoblasts as revealed by May-Giemsa staining, brilliant cresyl blue supravital staining, phase-contrast microscopy, vital staining and electronmicroscopy. are illustrated in the tables. en-copyright= kn-copyright= en-aut-name=SanadaHiroshi en-aut-sei=Sanada en-aut-mei=Hiroshi kn-aut-name=真田浩 kn-aut-sei=真田 kn-aut-mei=浩 aut-affil-num=1 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=2 ORCID= en-aut-name=KotsukaTakashi en-aut-sei=Kotsuka en-aut-mei=Takashi kn-aut-name=小塚堯 kn-aut-sei=小塚 kn-aut-mei=堯 aut-affil-num=3 ORCID= en-aut-name=OnoyeOsamu en-aut-sei=Onoye en-aut-mei=Osamu kn-aut-name=尾上修 kn-aut-sei=尾上 kn-aut-mei=修 aut-affil-num=4 ORCID= en-aut-name=SakikawaYoshinobu en-aut-sei=Sakikawa en-aut-mei=Yoshinobu kn-aut-name=咲川嘉信 kn-aut-sei=咲川 kn-aut-mei=嘉信 aut-affil-num=5 ORCID= en-aut-name=SaiharaTatsuro en-aut-sei=Saihara en-aut-mei=Tatsuro kn-aut-name=西原達郎 kn-aut-sei=西原 kn-aut-mei=達郎 aut-affil-num=6 ORCID= en-aut-name=HonkeKazunori en-aut-sei=Honke en-aut-mei=Kazunori kn-aut-name=本家和紀 kn-aut-sei=本家 kn-aut-mei=和紀 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=2 article-no= start-page=539 end-page=559 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the individual difference of adult human cerebral motor area in macroscopic and histologic way kn-title=肉眼的並に組織学的に見たる成人大脳運動領域の個人差に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The brain was fixed with formalin, washed by water, dehydrated with alcohol and etheralcohol, inbedded in celloidin and then stained by Nissl's method. The cells larger than 27.5 were to be considered as the Betz-cells. The area, where the Betzcells were found, were regarded as the motor area and the schemata of 70 cases of motor cortex were made. The fact was cleared from those schemata, that in the vicinity of th motor area those, which showed similar macroscopic findings, had similar extension of the motor area. The schemata of the macroscopic figure of the motor cortex were classified into 5 types and each type had its own shape of the motor area. There were a few exceptions among them, but they had also some close relation to the sulci. Among the 70 cases, those. in which the sulcus praecentralis superior was the anterior border, had the majority of 72.9%. In about 60% of all cases the motor area on one hemisphere was similar to the other side. en-copyright= kn-copyright= en-aut-name=OotaRyosuke en-aut-sei=Oota en-aut-mei=Ryosuke kn-aut-name=太田亮介 kn-aut-sei=太田 kn-aut-mei=亮介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6657 end-page=6667 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immuno-histological Studies on Hepatitis Part 3. A Study on the Pathogenesis of the So-called Hapatitic Cholecystopathy kn-title=肝炎に関する免疫組織学的研究 第3編 いわゆる肝炎性胆のう症の発生病理に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the cases of infectious hepatitis that has a complication of cholecystopathy, the author studied mainly its pathogenesis; and obtained the following results. 1. Out of 138 cases with hepatitis 33 cases (23.9%) had cholecystopathy as the complication. When these 33 cases are studied histologically by liver biopsy, periacinar form of chronic infectious hepatitis is found in 13 cases (39.3%), occupying the greatest percentage; followed by acute infectious hepatitis in 5 cases (15.2%), parenchymatous form of chronic infectious hepatitis in 4 (12.1%), posthepatitic cirrhosis in 4 (12.1%); and posthepatitic fibrosis in 2 (6.1%). On the other hand, judging cholecystopathy from various patho-histological forms, cholangiolitic hepatitis in 100%; periacinar form of chronic infectious hepatitis in 43.3%; posthepatitic fibrosis in 28.6%; parenchymatous form of chronic infectious hepatitis in 20%; posthepatitic cirrhosis in 11.9%; and acute infectious hepatitis in 11.8%. 2. Those showing biliary dyskinesia are mainly composed of the form revealing no marked changes in the liver biopsy (so-called posthepatitis syndrome) or the periacinar form of chronic infectious hepatitis. 3. Those having the complication of cholecystitis are more frequently found in acute infectious hepatitis and posthepatitic cirrhosis. 4. Generally even in the liver biopsy at the time of operation the infiltration of round cells and edema formation in portal region are characteristic traits of the common cholecystitis. 5. In the necropsy of infectious hepatitis likewise the liver and gallbladder are affected simultaneously; and the edema formation from the sublayer of mucous membrane to the sublayer of serous membrane and the congestion of capillary blood vessels with cell infiltration are the main common histological changes in the gallbladder. 6. When the antiserum obtained from the rabbit sensitized with dog abdominal organs (liver, gallbladder, duodenum, stomach, and rectal mucous membrane) as the antigen is injected into dogs, allergic cholecystitis can be induced in 100% of the animals with the use of gallbladder antiserum; in 80% with liver antiserum; in 60% with antiserum of rectal mucous membrane; and in 40% each with stomach antiserum or with antiserum of duodenal mucous membrane. In these instances intralobular and portal cell infiltration and edema formation in portal region can also be observed. 7. The characteristic traits of hepatitic cholecystopathy are the edema formation extending from the sublayer of the gallbladder mucous membrane to the sublayer of serous membrane and cell infiltration around blood vessels. As for the pathogenesis there seems to multiple factors; namely, dyscholia due to functional disturbances of the liver, the loss of the gallbladder motility due to invasion of inflammation inducing substances from portal tract through lymph ducts on serous inflammation, and also it is possible to be met with the secondary infection with an increase in the number of intestinal bacteria coexisting, and in some the involvement of allergic inflammation in gallbladder can be recognized. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6645 end-page=6656 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immuno-histological Studies on Hepatitis Part 2. Immuno-histological Study on Liver Auto-antibody and Homologous Liver Antibody kn-title=肝炎に関する免疫組織学的研究 第2編 肝自己並に同種抗体に関する免疫組織学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. From the standpoints of the complement fixation reaction and the tissue reaction it has been proven that the liver homologous immunicity can be accomplished in rabbit liver by injecting homologous liver emulsion into the animals without resorting to Freund's adjuvant method. 2. When the liver tissue is rapidly destroyed by injecting an hypertonic physiological saline solution into the liver, the production of liver auto-antibody can clearly be recognized, and the sensitized state with tissue reaction can also be observed. 3. In comparing the tissue reaction in the case sensitized with microsome fraction of homologous liver or homologous liver phosphatid antigen with the reaction observable in the liver injected with homologous liver emulsion, hardly any difference can be seen in the former, while the tissue reactions such as necrosis of liver cells etc. are far more marked in the latter. 4. Although there are few differences in the tissue reaction according to the dosis and the titer of the injected homologous liver antiserum, a cytotoxin-like action and a relative organ specificity were recognized. 5. The mice sensitized with the homologous liver emulsion previously are secondary infected with ectromelia virus, so that serous inflammation of the liver tissue are used to be found additionally, moreover by the sensitization above mentioned the histological changes in the liver tissue of the mice become more stronger. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6633 end-page=6644 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immuno-histological Studies on Hepatitis Part 1. Relationship between the Liver Tissue Reaction and the So-called Liver Auto-antibody kn-title=肝炎に関する免疫組織学的研究 第1編 肝組織反応といわゆる肝自己抗体の関聯について en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to elucidate the clinical significance of the so-called liver auto-antibody and heterophile antibody by means of Paul-Bunnell's reaction, the author studied histologically 138 cases of liver diseases including infectious hepatitis with liver biopsy specimens; and obtained the following results. 1. Those liver diseases in which the liver auto-antibody can be detected are infectious hepatitis, chronic infectious mononucleosis, and lupus erythematodes, and in addition, there are fatty liver, hepatoler ticular degeneration (Wilson's disease), mechanical jaundice, Banti's syndrom, and hepatoma; and all the liver auto-antibody of them start from necrotic destruction of liver tissue. 2. The liver auto-antibody titer were well correlated with the proliferation of interstitial connective tissue, exsudation in sinusoid, liver cell necrosis, and stellate cell activation, but have poor correlation with the portal cell infiltration and degeneration of liver cells. 3. Active chronic infectious hepatitis that later develops to liver cirrhosis, cholangiolitic hepatitis, and a portion of the chronic infectious hepatitis in which inflammation spreads to portal and periportal region show a high liver auto-antibody titer which persists for a long period of time. However, in such diseases as active chronic epidemic hepatitis or in serum hepatitis (posttransfusion hepatitis), the possibility of the liver auto-antibody becoming an endogenous factor to spread the local tissue changes to wider area is doubtful in the former, but it markedly strong in the latter. 4. It has been confirmed that heterophile antibody is produced by viral infection in infections hepatitis. Especially high agglutination titer can be found in posthepatitic liver cirrhosis and parenchymatous form of chronic infectious hepatitis, and assuming those titer over 40 times to be agglutination positive, it also has patho-histologically a clinical significance. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=7-1 article-no= start-page=3695 end-page=3702 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Nucleic Acids Metabolism of Bacteria Part II. P(32) incorporation into nucleic acids and proteins kn-title=細菌の核酸代謝について 第2篇 核酸，蛋白えのP(32)のincorporation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using the standard strains of Staph. aureus and Sh. flexneri stocked in the labolatory, the author studied the effect of addition of aureomycin, chloramphenical, Co(++), Mg(++) and Fe(++) on the quantitative changes of RNA, DNA and proteins in the bacteria that was shaken in it's suspension, and also investigated the P(32) incorporations into the nucleic acids and the preteins fractions of these bacteria. The results obtained are following. 1) The amouot of RNA showed marked increase in the bacteria shaken with the addition of glucose into the snspension, whereas that of proteins was found to show only slight increase. The addition of peptone or peptone and glucose into the suspension showed the decrease of the RNA amount, but did the marked increase of the proteins. 2) Aureomycin, chloramphemicol and Co(++) inhibited the increase of the prpteins amount, but Mg(++) and Fe(++) accelerated it. 3) The P(32) incorporations into the nucleic acid and the protein fractions were increased with the addition of peptone, especially in the case of glucose and peptone. en-copyright= kn-copyright= en-aut-name=OtaHajime en-aut-sei=Ota en-aut-mei=Hajime kn-aut-name=太田肇 kn-aut-sei=太田 kn-aut-mei=肇 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=7-1 article-no= start-page=3689 end-page=3694 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Nucleic Acids Metabolism of Bacteria Part I. Quantitative changes of RNA and DNA kn-title=細菌の核酸代謝について 第1篇 RNA, DNAの量的変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the use of the standard strains, namely, Staph. aureus, Staph. albus, Sh. flexneri 2a, Sal. typhi 57 S, and Sal. typhi 57 R stocked in our department, the author studied the relations between the quantities of nucleic acids, RNA and DNA, in the cells and the duration of cultures, and carbon sources in the media; and also investigated the quatitative changes of nucleic acids of the resting cells after shaking of bacterial suspension. The following results were obtained. 1) The quantity of RNA was found to be more laage in the cells of younger culture. It can be asid that the amount of RNA taking the part in protein synthesis was increased in the cells that art multiplying actively. 2) It was found rather large quantity of RNA in the case of bacteria, when it was cultured on the media that were containing carbon sources, especially glucose. 3) The quantity of RNA was gradually decreased by the shaking of the suspension of resting cells. However, it was observed the marked increase of the quantity, if glucose was added into the suspension. But the addition of peptone itself or combination with carbon source, like glucose, revealed decrease of the quantity. en-copyright= kn-copyright= en-aut-name=OtaHajime en-aut-sei=Ota en-aut-mei=Hajime kn-aut-name=太田肇 kn-aut-sei=太田 kn-aut-mei=肇 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=7-8 article-no= start-page=821 end-page=830 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=19890831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Parasitic diseases brought to the Department of Parasitology, in five years, 1984-1989 kn-title=最近5年間に経験した寄生虫・衛生動物疾患症例について(1984-1989) en-subtitle= kn-subtitle= en-abstract= kn-abstract=From April 1984 to March 1989, we accepted 399 samples and specimens from hospitals and clinics, and diagnosed 86 cases of parasitic diseases. In this paper, 14 case-reports of zoonoses, larva migrans, imported disease and opportunistic infection are presented and discussed. en-copyright= kn-copyright= en-aut-name=MatsuokaHiroyuki en-aut-sei=Matsuoka en-aut-mei=Hiroyuki kn-aut-name=松岡裕之 kn-aut-sei=松岡 kn-aut-mei=裕之 aut-affil-num=1 ORCID= en-aut-name=AjiToshiki en-aut-sei=Aji en-aut-mei=Toshiki kn-aut-name=安治敏樹 kn-aut-sei=安治 kn-aut-mei=敏樹 aut-affil-num=2 ORCID= en-aut-name=IshiiAkira en-aut-sei=Ishii en-aut-mei=Akira kn-aut-name=石井明 kn-aut-sei=石井 kn-aut-mei=明 aut-affil-num=3 ORCID= en-aut-name=TonguYasumasa en-aut-sei=Tongu en-aut-mei=Yasumasa kn-aut-name=頓宮廉正 kn-aut-sei=頓宮 kn-aut-mei=廉正 aut-affil-num=4 ORCID= en-aut-name=OhtaNobuo en-aut-sei=Ohta en-aut-mei=Nobuo kn-aut-name=太田伸生 kn-aut-sei=太田 kn-aut-mei=伸生 aut-affil-num=5 ORCID= en-aut-name=EdahiroToru en-aut-sei=Edahiro en-aut-mei=Toru kn-aut-name=枝広徹 kn-aut-sei=枝広 kn-aut-mei=徹 aut-affil-num=6 ORCID= en-aut-name=DoiHiroyuki en-aut-sei=Doi en-aut-mei=Hiroyuki kn-aut-name=土居弘幸 kn-aut-sei=土居 kn-aut-mei=弘幸 aut-affil-num=7 ORCID= en-aut-name=KimuraJulieta Yuri en-aut-sei=Kimura en-aut-mei=Julieta Yuri kn-aut-name=木村ジュリエッタ・Ｙ kn-aut-sei=木村 kn-aut-mei=ジュリエッタ・Ｙ aut-affil-num=8 ORCID= en-aut-name=ItanoKazuo en-aut-sei=Itano en-aut-mei=Kazuo kn-aut-name=板野一男 kn-aut-sei=板野 kn-aut-mei=一男 aut-affil-num=9 ORCID= en-aut-name=MorishigeKazuhisa en-aut-sei=Morishige en-aut-mei=Kazuhisa kn-aut-name=森重和久 kn-aut-sei=森重 kn-aut-mei=和久 aut-affil-num=10 ORCID= en-aut-name=SongJigo en-aut-sei=Song en-aut-mei=Jigo kn-aut-name=宋晶 kn-aut-sei=宋 kn-aut-mei=晶 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部寄生虫学教室 en-keyword=人畜共通感染症 kn-keyword=人畜共通感染症 en-keyword=輸入寄生虫病 kn-keyword=輸入寄生虫病 en-keyword=日和見感染症 kn-keyword=日和見感染症 en-keyword=幼虫移行症 kn-keyword=幼虫移行症 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=189 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinicopathological study of distal bile duct carcinoma at Fukuyama Medical Center kn-title=当院における下部胆管癌手術症例の治療成績 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced 20 patients with distal bile duct carcinoma from May, 1997 to December, 2007. The male/female ratio was 11/9 and the average age was 69.6 years. The operative procedures were as follows：pancreaticoduodenectomy (PD), 9；pyrolus preserving pancreaticoduodenectomy (PPPD), 8；subtotal stomach preserving pancreaticoduodenectomy (SSPPD), 2 and hepatico-jejunostomy without resection, 1. We performed a clinicopathological study on 16 patients with distal bile duct carcinoma, excluding 3 operation-related deaths and 1 unresectable case. The cumulative survival rate was 70% at 3 years and 11% at 5 years. The 3-year survival rates at fStageⅡ, fStageⅣa and fStageⅣb were 100%, 80% and 0%, respectively. Log-rank analysis revealed that pathological pancreatic and duodenal invasion and curative resectability may be prognostic factors, while lymph node metastasis and perineural and stump invasion did not affect prognosis. Six recurrences in the 11 curative resection cases (54.5%) were observed；therefore, postoperative systemic chemotherapy is warranted to curtail recurrence in advanced distal bile duct carcinoma. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=2 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=4 ORCID= en-aut-name=TsunemitsuYosuke en-aut-sei=Tsunemitsu en-aut-mei=Yosuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=5 ORCID= en-aut-name=OhtsukaShinya en-aut-sei=Ohtsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=6 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=7 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=8 ORCID= en-aut-name=SonobeHiroshi en-aut-sei=Sonobe en-aut-mei=Hiroshi kn-aut-name=園部宏 kn-aut-sei=園部 kn-aut-mei=宏 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=中国中央病院　臨床検査科 en-keyword=下部胆管癌 (distal bile duct carcinoma) kn-keyword=下部胆管癌 (distal bile duct carcinoma) en-keyword=手術 (operation) kn-keyword=手術 (operation) en-keyword=予後規定因子 (independent prognostic factors) kn-keyword=予後規定因子 (independent prognostic factors) END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=6 article-no= start-page=471 end-page=480 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=198512 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Paradoxical antagonism of neuromuscular block by vecuronium metabolites. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Vecuronium is hydrolyzed in the body to 3-deacetyl (ORG 7268), 17-deacetyl (ORG NC58), and 3, 17-bis-deacetyl (ORG 7402) derivatives. Interactions of vecuronium and these metabolites were studied in phrenic nerve-hemidiaphragm preparations of rats. As already reported, ORG 7268 had a potent neuromuscular blocking action, and ORG NC58 and ORG 7402 had a weak neuromuscular blocking action. As expected, ORG 7268 increased the degree of neuromuscular block by vecuronium. However, a low concentration (10 microM) of ORG NC58 and ORG 7402 reversed the block by vecuronium. At a high concentration (50 microM), ORG NC58 and ORG 7402 increased the degree of block by vecuronium. Although we do not have enough data to explain these paradoxical reversal of neuromuscular block at this moment, we postulate that these results reflect the interaction between "slow" and "fast" competitive antagonists. Regardless of the mechanism, it should be emphasized that the concentrations of ORG NC58 and ORG 7402 which are necessary to reverse the block are much lower than those which facilitate the block. It is conceivable that this paradoxical reversal of the block occurs in experimental and clinical situations. Therefore, in determining the neuromuscular blocking action of a compound, the "antagonistic" effect of its metabolites should also be considered.

en-copyright= kn-copyright= en-aut-name=OhtaYoshio en-aut-sei=Ohta en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=vecuronium kn-keyword=vecuronium en-keyword=neuromuscular trasmission kn-keyword=neuromuscular trasmission en-keyword=drug interaction kn-keyword=drug interaction en-keyword=competitive inhibition kn-keyword=competitive inhibition en-keyword=muscle relaxant kn-keyword=muscle relaxant END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=1 article-no= start-page=15 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Prototype Model Using Clinical Document Architecture (CDA) with a Japanese Local Standard : Designing and Implementing a Referral Letter System en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Since clinical document architecture (CDA) became an American National Standards Institute (ANSI)-approved health level seven (HL7) Standard, many countries have begun making an eff ort to make local standards conform to CDA. In order to make CDA compatible with the many diff erent local standards existing in diff erent countries, we designed a prototype model using HL7 CDA R2 with medical markup language (MML), a Japanese medical data exchange standard. Furthermore, a referral letter system based on this model was developed. Archetypes were used to express medical concepts in a formal manner and to make 2 diff erent standards work collaboratively. We share herein the experience gathered in designing and implementing a referral letter system based on HL7 CDA, Release 2 (CDA R2). We also outline the challenges encountered in our project and the opportunities to widen the scope of this approach to other clinical documents.

en-copyright= kn-copyright= en-aut-name=YongHuang en-aut-sei=Yong en-aut-mei=Huang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=JinqiuGuo en-aut-sei=Jinqiu en-aut-mei=Guo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhtaYoshio en-aut-sei=Ohta en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Dalian Medical University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=health level seven kn-keyword=health level seven en-keyword=clinical document architecture kn-keyword=clinical document architecture en-keyword=medical markup language kn-keyword=medical markup language en-keyword=archetype kn-keyword=archetype END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=15 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Circulatory changes in rheumatoid fingers as estimated by thermography and photoelectric plethysmography kn-title=サーモグラフィーおよび指尖容積脈波による慢性関節リウマチ患者手指の循環障害の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In an attempt to evaluate circulatory changes in patients with rheumatoid arthritis (RA), 20 patients with classical or definite RA as determined by ARA criteria and twenty healthy volunteers serving as control were randomly selected. None of the patients showed the clinical signs suggesting Raynaud's phenomenon. Thermograms as well as photoelectric plethysmograms were obtained solely from the right middle finger tip of each examinee. The whole hand was then immersed in the cold (10℃) water and kept there for one minute. After wiping away the wet hand with a dry towel very gently, we followed the sequential changes of the tempe· rature of the third finger tip and the period of time necessary for the tip to return to the original temperature prior to the cold water immersion was measured and expressed as 'return time' in minute. Before exposure to the cold, the mean values of temperature of the finger tips between the two groups were not significantly different. As opposed to the normal pattern in which one can find the warmest point at the finger tip and which was more frequently found in the control group of the current study, a type in which the distal part of the finger was much cooler than the proximal area (so-called 'distal cold type') was observed in 8 RA patients, whereas only four demonstrated this pattern in the control group. After brief exposure to the cold, eight out of 20 rheumatoid patients showed much prolonged return time (longer than 20 minutes), while only three of 20 controls remained with prolonged cool periphery, The difference between the two, however, was not statistically significant. Studies of the digital plethysmograph revealed that 70% of all the rheumatoids showed abnormal patterns: sclerotic and monophasic waves were discovered in 55% of the patients. In contrast, seventy percent of the normal control demonstra· ted normal wave pattern. Although the significant difference was not noted, the mean height of the systolic peak of the plethysmograph derived from the rheumatoid group tended to be much reduced, suggesting the reduced blood volume at the finger tips. Six RA patients and 13 normals who showed normal plethysmographic pattern before immersion in the cold water, demonstrated rapid return to the original temperature. Only in one normal control with a normal wave pattern, prolonged return time was observed, although the height of the systolic peak of the plethysmogram in this particular case was well within normal limit. Digital circulatory disturbance, however, was strongly suspected in eight RA patients with severely prolonged return time, They all showed abnormal wave patterns of the plethysmogram, including 2 cases with peripheral plateau wave, Markedly reduced heights of the systolic peaks were also demonstrated in all. Further elaborate studies including digital arteriography were indicated to implicate any organic change in the digital vessels, such as digital arteritis in RA first reported by Bywaters in 1957. en-copyright= kn-copyright= en-aut-name=OhtaTakamasa en-aut-sei=Ohta en-aut-mei=Takamasa kn-aut-name=太田隆正 kn-aut-sei=太田 kn-aut-mei=隆正 aut-affil-num=1 ORCID= en-aut-name=TokiokaMasaaki en-aut-sei=Tokioka en-aut-mei=Masaaki kn-aut-name=時岡正明 kn-aut-sei=時岡 kn-aut-mei=正明 aut-affil-num=2 ORCID= en-aut-name=TakasugiKiyoshi en-aut-sei=Takasugi en-aut-mei=Kiyoshi kn-aut-name=高杉潔 kn-aut-sei=高杉 kn-aut-mei=潔 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉医学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉医学部門 affil-num=3 en-affil= kn-affil=岡山大学温泉研究所温泉医学部門 END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=3-4 article-no= start-page=349 end-page=367 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Theoretical Character of Lenin's "Imperialism" kn-title=『帝国主義論』の性格についての覚書―帝国主義論史研究の視角から― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学名誉教授 END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue=4 article-no= start-page=133 end-page=155 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Imperialismustheorie und "Das Kapital" kn-title=帝国主義論と『資本論』―ヒルファディング『金融資本論』とレーニン『帝国主義論』― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=3-4 article-no= start-page=277 end-page=297 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=19880120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lenin on Capitalism and the National Question kn-title=レーニンにおける資本主義と民族問題 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=1 article-no= start-page=133 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910628 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (I) kn-title=マルクス主義理論史研究の課題（I）―松岡・丸山・田中氏の近著によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=2 article-no= start-page=125 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19911016 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (II) kn-title=マルクス主義理論史研究の課題（II）―松岡・丸山・田中氏の近著によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=4 article-no= start-page=139 end-page=158 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (III) kn-title=マルクス主義理論史研究の課題（III）―松岡・丸山・田中氏の近著によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=1 article-no= start-page=123 end-page=135 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19920526 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (IV) kn-title=マルクス主義理論史研究の課題（IV）―松岡・丸山・田中氏の近著によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=3 article-no= start-page=453 end-page=467 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (V) kn-title=マルクス主義理論史研究の課題（V）―相田慎一氏の近著によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=1 article-no= start-page=97 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940624 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (VI) kn-title=マルクス主義理論史研究の課題（VI）―保住敏彦氏の近著によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=2 article-no= start-page=75 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (VII) kn-title=マルクス主義理論史研究の課題（VII）―河野裕康氏の近著によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=4 article-no= start-page=181 end-page=198 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (VIII) kn-title=マルクス主義理論史研究の課題（VIII）―上条勇氏の近著によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue= article-no= start-page=21 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100326 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Reports in International Symposium kn-title=シンポジウム「北東アジアと地域統合」報告論文についての説明 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=39 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinicopathological study of distal bile duct carcinoma at Fukuyama Medical Center kn-title=当院における下部胆管癌手術症例の治療成績 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced 20 patients with distal bile duct carcinoma from May, 1997 to December, 2007. The male/female ratio was 11/9 and the average age was 69.6 years. The operative procedures were as follows : pancreaticoduodenectomy (PD), 9 ; pyrolus preserving pancreaticoduodenectomy (PPPD), 8 ; subtotal stomach preserving pancreaticoduodenectomy (SSPPD), 2 and hepatico-jejunostomy without resection, 1. We performed a clinicopathological study on 16 patients with distal bile duct carcinoma, excluding 3 operation-related deaths and 1 unresectable case. The cumulative survival rate was 70% at 3 years and 11% at 5 years. The 3-year survival rates at fStageII, fStageIVa and fStageIVb were 100%, 80% and 0%, respectively. Log-rank analysis revealed that pathological pancreatic and duodenal invasion and curative resectability may be prognostic factors, while lymph node metastasis and perineural and stump invasion did not affect prognosis. Six recurrences in the 11 curative resection cases (54.5%) were observed ; therefore, postoperative systemic chemotherapy is warranted to curtail recurrence in advanced distal bile duct carcinoma. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=2 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=4 ORCID= en-aut-name=TsunemitsuYosuke en-aut-sei=Tsunemitsu en-aut-mei=Yosuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=5 ORCID= en-aut-name=OhtsukaShinya en-aut-sei=Ohtsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=6 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=7 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=8 ORCID= en-aut-name=SonobeHiroshi en-aut-sei=Sonobe en-aut-mei=Hiroshi kn-aut-name=園部宏 kn-aut-sei=園部 kn-aut-mei=宏 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=中国中央病院　臨床検査科 en-keyword=下部胆管癌 (distal bile duct carcinoma) kn-keyword=下部胆管癌 (distal bile duct carcinoma) en-keyword=手術 (operation) kn-keyword=手術 (operation) en-keyword=予後規定因子 (independent prognostic factors) kn-keyword=予後規定因子 (independent prognostic factors) END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=5-1 article-no= start-page=2139 end-page=2143 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590415 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nitrogen Metabolism of the Brain Part 16 Studies on the Activities of Glutamine Synthesis in the Brain Extract of the Rats Treated with Various Methods kn-title=脳の窒素代謝 第16篇 各種処置大黒鼠脳髄extractのグルタミン合成能 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The activities of glutamine synthesis in the brain extract of the rat treated with various methods, were observed by means of the Conway's microdiffusion analysis. The brain extract were incubated at 37℃, pH 7.2 for 25 minutes under aerobic condition. 1) The activity of glutamine synthesis in the rat' brain extract treated with intensive electro-shock series, averaged 2.21μM per tube and showed an increase in comparison with the control value. 2) In the insulin shock series it was 1.04μM per tube in average and was a lower level than the control value. 3) The activity averaged 0.91μM per tube in the Philopon (Pervitin) administration series. 4) In the Ritalin treatment series its average activity was 1.10μM per tube and so Philopon and Ritalin decreased in its comparative activities with the control. en-copyright= kn-copyright= en-aut-name=OtaTsuneko en-aut-sei=Ota en-aut-mei=Tsuneko kn-aut-name=太田典子 kn-aut-sei=太田 kn-aut-mei=典子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=5-1 article-no= start-page=2133 end-page=2137 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590415 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nitrogen Metabolism of the Brain Part 15 Studies on Activities of Glutamine Synthesis in the Brain Extracts of Various Animals kn-title=脳の窒素代謝 第15篇 各種動物脳髄extractのグルタミン合成能 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The activity of glutamine synthesis in the brain extracts of various animals were observed by means of the Conwsy's microdiffusion analysis. The brain extracts were incubated at 37℃, pH 7.2 for 25 minutes under aerobic condition. 1) The activity of glutamine synthesis in the normal rat brain extract was 1.53 μM per tube on an average. 2) In the mouse brain it averaged 0.81 μM per tube and was lower than the rat's. 3) It was 1.18 μM per tube on an average in the cat-fish brain. 4) In the human brain, even though only two cases, it was 1.80 μM per tube in average. en-copyright= kn-copyright= en-aut-name=OtaTsuneko en-aut-sei=Ota en-aut-mei=Tsuneko kn-aut-name=太田典子 kn-aut-sei=太田 kn-aut-mei=典子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=5-1 article-no= start-page=2127 end-page=2132 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590415 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nitrogen Metabolism of the Brain Part 14 Influences Sodium Monofluoracetate on Ammonia, Glutamine and Amino Acids in the Rat Brain kn-title=脳の窒素代謝 第14篇 モノ弗化醋酸ナトリウム投与大黒鼠脳髄アンモニア，グルタミン並びにアミノ酸量 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Administering the Sodium Monofluoracetate, SMFA, to the rat, the quantitative determination of ammonia and glutamine in the rat brain was made by the Conway's microdiffusion analysis and on the other hand amino acids by the paperchromatography. The results as follow, To wit: 1) In the convulsion stage caused by SMFA administration, ammonia content in its brain was 2.18 mg%, glutamine 63.9 m%, glutamic acid 120.7 mg%, γ-aminobutylic acid 25.2 mg% and aspartic acid 42.8 mg%. 2) About the hourly observation after the SMFA adiministration to the rat. a) Ammonia content in its brain showed gradual increase in 4 hours up to 4 times of control value. b) Glutamic acid content showed always low level in 4 hours but the lowest one in the first one hour. c) Glutamine content also decreased in all 4 hours, remarkably at the first and thlast. d) γ-amino butylic acid content decreased. e) Aspartic acid content increased remarkably in the first 10 minutes, and then decreased. But it showed remarkably increased at the 4th hour again. en-copyright= kn-copyright= en-aut-name=OtaTsuneko en-aut-sei=Ota en-aut-mei=Tsuneko kn-aut-name=太田典子 kn-aut-sei=太田 kn-aut-mei=典子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=801 end-page=810 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Epidemiological Observations on Infectious Hepatitis Prevailed in Okayama Prefecture kn-title=岡山県における流行性肝炎の流行に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=6246 infectious hepatitis cases treated at 25 hospitals located in Okayama Prefecture during the last six years, 1952 to 1957, were studied mainly from the epidemiological point of view, and the following results were obtained. 1) Infectious hepatitis has been prevailed all over the prefecture since the initial epidemic in 1951. As the mode of epidemic became protracted, chronic and abortive forms were prone to increase in number. The ratio of total patients to infectious hepatitis cases was 1.27 per cent. 2) Extensive infections among villagers were noted in 73 hamlets, and it was presumed that the epidemic has been prevailed over the whole prefecture taking a hamlet, village or a town as unit. Infections among family were noted in 62 families, however, fnrther detailed study in the epidemic areas might show the higher morbidity. It was not certain whether these infections were entirely family or simultaneous infections. 3) As to seasonal occurence, considerable number of cases had onset of the disease during the period of early summer to early fall. 4) As to age, it has ranged mostly from the second to third decade, rather many in children but not rare in the aged. As to sex, predominant in males in general, but considerable differences were seen among hospitals and times. No definite relationship was noted between the epidemc and sex. 5) Throughout the last six years there have been 38.7 per cent of chronic hepatitis cases. In 41.3 per cent of the whole patients presented jaundice in their clinical courses. The fact that the longer the period of the epidemic the more increase increase in anicteric cases was noted. 6) Two year's follow-up studies after the epidemic, showed 209 of relapsed cases in whom 36.4 per cent were icteric. 7) 110 cases has jaundice, which was thought to be infectious hepatitis, in the past. Some of them were presumably reinfections or superinfections but definite conclusion could not be made. 8) 20 cases of fulminant hepatitis, malignant type of infectious hepatitis, and 6 cases of protracted form were studied. 22 cases of them were fatal. Such severe hepatitis patients were seen mainly in males of the second and third decades. 9) 61 cases (0.98%) developed postnecrotic cirrhosis, and 10 cases of them were fatal. 10) Serum hepatitis was noted in 1.6 per cent of the whole patients seen in Medical Services at 18 hospitals in Okayama Prefecture during the last six years, 1952 to 1957. No definite correlation between the epidemic of infectious hepatitis and outbreak of serum hepatitis was noted. en-copyright= kn-copyright= en-aut-name=KosakaKiyowo en-aut-sei=Kosaka en-aut-mei=Kiyowo kn-aut-name=小坂淳夫 kn-aut-sei=小坂 kn-aut-mei=淳夫 aut-affil-num=1 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=2 ORCID= en-aut-name=ShimadaYoshihiro en-aut-sei=Shimada en-aut-mei=Yoshihiro kn-aut-name=島田宜浩 kn-aut-sei=島田 kn-aut-mei=宜浩 aut-affil-num=3 ORCID= en-aut-name=YamabukiTakahiro en-aut-sei=Yamabuki en-aut-mei=Takahiro kn-aut-name=山吹隆寛 kn-aut-sei=山吹 kn-aut-mei=隆寛 aut-affil-num=4 ORCID= en-aut-name=KawaguchiMasamitsu en-aut-sei=Kawaguchi en-aut-mei=Masamitsu kn-aut-name=川口正光 kn-aut-sei=川口 kn-aut-mei=正光 aut-affil-num=5 ORCID= en-aut-name=YamamotoShigeru en-aut-sei=Yamamoto en-aut-mei=Shigeru kn-aut-name=山本繁 kn-aut-sei=山本 kn-aut-mei=繁 aut-affil-num=6 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=7 ORCID= en-aut-name=UjikeMutsuo en-aut-sei=Ujike en-aut-mei=Mutsuo kn-aut-name=氏家睦夫 kn-aut-sei=氏家 kn-aut-mei=睦夫 aut-affil-num=8 ORCID= en-aut-name=KusakaYoshiro en-aut-sei=Kusaka en-aut-mei=Yoshiro kn-aut-name=草加芳郎 kn-aut-sei=草加 kn-aut-mei=芳郎 aut-affil-num=9 ORCID= en-aut-name=MitsudaToshihiro en-aut-sei=Mitsuda en-aut-mei=Toshihiro kn-aut-name=光田利弘 kn-aut-sei=光田 kn-aut-mei=利弘 aut-affil-num=10 ORCID= en-aut-name=KiharaTsuyoshi en-aut-sei=Kihara en-aut-mei=Tsuyoshi kn-aut-name=木原彊 kn-aut-sei=木原 kn-aut-mei=彊 aut-affil-num=11 ORCID= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=12 ORCID= en-aut-name=HaraokaSyoichi en-aut-sei=Haraoka en-aut-mei=Syoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=13 ORCID= en-aut-name=AmiokaTadashi en-aut-sei=Amioka en-aut-mei=Tadashi kn-aut-name=網岡忠 kn-aut-sei=網岡 kn-aut-mei=忠 aut-affil-num=14 ORCID= en-aut-name=IshimitsuTetsusaburo en-aut-sei=Ishimitsu en-aut-mei=Tetsusaburo kn-aut-name=石光鉄三郎 kn-aut-sei=石光 kn-aut-mei=鉄三郎 aut-affil-num=15 ORCID= en-aut-name=KonoHiroya en-aut-sei=Kono en-aut-mei=Hiroya kn-aut-name=河野浩哉 kn-aut-sei=河野 kn-aut-mei=浩哉 aut-affil-num=16 ORCID= en-aut-name=MitsumotoToshiro en-aut-sei=Mitsumoto en-aut-mei=Toshiro kn-aut-name=光本敏郎 kn-aut-sei=光本 kn-aut-mei=敏郎 aut-affil-num=17 ORCID= en-aut-name=AisakaTadakazu en-aut-sei=Aisaka en-aut-mei=Tadakazu kn-aut-name=相坂忠一 kn-aut-sei=相坂 kn-aut-mei=忠一 aut-affil-num=18 ORCID= en-aut-name=KosakaChuihiro en-aut-sei=Kosaka en-aut-mei=Chuihiro kn-aut-name=小坂忠一郎 kn-aut-sei=小坂 kn-aut-mei=忠一郎 aut-affil-num=19 ORCID= en-aut-name=MoritaniYui en-aut-sei=Moritani en-aut-mei=Yui kn-aut-name=森谷有為 kn-aut-sei=森谷 kn-aut-mei=有為 aut-affil-num=20 ORCID= en-aut-name=TabuchiHiroshi en-aut-sei=Tabuchi en-aut-mei=Hiroshi kn-aut-name=田渊博司 kn-aut-sei=田渊 kn-aut-mei=博司 aut-affil-num=21 ORCID= en-aut-name=HashimotoKyoji en-aut-sei=Hashimoto en-aut-mei=Kyoji kn-aut-name=橋本恭治 kn-aut-sei=橋本 kn-aut-mei=恭治 aut-affil-num=22 ORCID= en-aut-name=KimuraKenichi en-aut-sei=Kimura en-aut-mei=Kenichi kn-aut-name=木村健一 kn-aut-sei=木村 kn-aut-mei=健一 aut-affil-num=23 ORCID= en-aut-name=KonoHiroshi en-aut-sei=Kono en-aut-mei=Hiroshi kn-aut-name=河野宏 kn-aut-sei=河野 kn-aut-mei=宏 aut-affil-num=24 ORCID= en-aut-name=TamaoHiroyasu en-aut-sei=Tamao en-aut-mei=Hiroyasu kn-aut-name=玉尾博康 kn-aut-sei=玉尾 kn-aut-mei=博康 aut-affil-num=25 ORCID= en-aut-name=HiguchiYosimitsu en-aut-sei=Higuchi en-aut-mei=Yosimitsu kn-aut-name=樋口祥光 kn-aut-sei=樋口 kn-aut-mei=祥光 aut-affil-num=26 ORCID= en-aut-name=YahataKatsumi en-aut-sei=Yahata en-aut-mei=Katsumi kn-aut-name=八幡勝美 kn-aut-sei=八幡 kn-aut-mei=勝美 aut-affil-num=27 ORCID= en-aut-name=ImaiHarujiro en-aut-sei=Imai en-aut-mei=Harujiro kn-aut-name=今井春路郎 kn-aut-sei=今井 kn-aut-mei=春路郎 aut-affil-num=28 ORCID= en-aut-name=KameyamaIchiro en-aut-sei=Kameyama en-aut-mei=Ichiro kn-aut-name=亀山一郎 kn-aut-sei=亀山 kn-aut-mei=一郎 aut-affil-num=29 ORCID= en-aut-name=ArijiSumiro en-aut-sei=Ariji en-aut-mei=Sumiro kn-aut-name=有地澄郎 kn-aut-sei=有地 kn-aut-mei=澄郎 aut-affil-num=30 ORCID= en-aut-name=FujimoriYasuhiko en-aut-sei=Fujimori en-aut-mei=Yasuhiko kn-aut-name=藤森恭彦 kn-aut-sei=藤森 kn-aut-mei=恭彦 aut-affil-num=31 ORCID= en-aut-name=NakagawaSyoso en-aut-sei=Nakagawa en-aut-mei=Syoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=32 ORCID= en-aut-name=HiranoYutaka en-aut-sei=Hirano en-aut-mei=Yutaka kn-aut-name=平野寛 kn-aut-sei=平野 kn-aut-mei=寛 aut-affil-num=33 ORCID= en-aut-name=KobayashiToshinari en-aut-sei=Kobayashi en-aut-mei=Toshinari kn-aut-name=小林敏成 kn-aut-sei=小林 kn-aut-mei=敏成 aut-affil-num=34 ORCID= en-aut-name=SeidoIchiro en-aut-sei=Seido en-aut-mei=Ichiro kn-aut-name=清藤一郎 kn-aut-sei=清藤 kn-aut-mei=一郎 aut-affil-num=35 ORCID= en-aut-name=TanabeIsao en-aut-sei=Tanabe en-aut-mei=Isao kn-aut-name=田辺功 kn-aut-sei=田辺 kn-aut-mei=功 aut-affil-num=36 ORCID= en-aut-name=TakedaKazuhisa en-aut-sei=Takeda en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=37 ORCID= en-aut-name=HayashiShinichiro en-aut-sei=Hayashi en-aut-mei=Shinichiro kn-aut-name=林愼一郎 kn-aut-sei=林 kn-aut-mei=愼一郎 aut-affil-num=38 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=13 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=14 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=15 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=16 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=17 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=18 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=19 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=20 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=21 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=22 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=23 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=24 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=25 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=26 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=27 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=28 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=29 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=30 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=31 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=32 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=33 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=34 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=35 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=36 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=37 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=38 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1-3 article-no= start-page=297 end-page=316 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Treatment of Malignant Tumors With Fibroblasts Inhibiting Agents Basic and Clinical Studies of Chloroquine Derivatives. (1) kn-title=線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 クロロキン剤の基礎と臨床（第一報） en-subtitle= kn-subtitle= en-abstract= kn-abstract=Followings are the results derived from the treatment of animal and human cancers with a fibroblasts inhibiting agent such as chloroquine, based on the unique idea of ours. 1). In implanted tumors of animals, the effect was noted in Bashford cancer and Brown-Pearce cancer relatively rich in connective tissue in terms of life prolongation, an inhibition of tumor growth and of decrease of liver catalase activity, an improvement of iron metabolism, an enlargement of necrotic area in histology, an inhibition of connective tissue conponents, and a decrease of acid mucopolysaccharides. A tendency for a decrease of amount and cell numbers of ascites was almost the only effect noted in Ehrlich cancer, Yoshida sarcoma, and MH 134 poor in connective tissue. 2). 75 cases of humau cancer were treated with this agent and among these 75 the effect was evaluated in 40 cases with definite histological diagnosis in respects with subjective and objective improvement. It was effective in 28 cases, resulted failure in 11 cases, and gave an obscure result in 1 case. Cases which were treated for more than 2m onths never resulted in therapeutic failure, indicating that the agent was somehow effective for all cases but those in the last stadium. In respect with organs involved, the effect was most prominent in lung cancer and urinary bladder cancer, somewhat less in gastric cancer, and often seen in carcinomatous peritonitis and many other advanced cancers. This effect was noted in a comparatively short period in terms of subjective improvement, regression in size of tumors in a number of cases, a decrease of serum lactic acid dehydrogenase, and improvement of general condition, a tendency for necrosis of tumor and an inhibition of interstitium. 3). The above results indicate that the agent is more effective for tumors rich in connective tissue and that it's secondary effect on tumors through the inhibition of interstitial connective tissue is considered as the operative mechanism of chloroquine against malignant tumors, but it's anti-inflammatory effect and generalized influence on hosts are to be taken into consideration. The agent is indicated in inoperable cases, postoperative relapse, or prior and following an operation. A search for stronger fibroblasts inhibiting agents and an evaluation of combined therapy with so called anti-cancer agents are being made and that with mitomycin C is giving a fairly promising result. en-copyright= kn-copyright= en-aut-name=HirakiKiyoshi en-aut-sei=Hiraki en-aut-mei=Kiyoshi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=2 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=3 ORCID= en-aut-name=AsanoKenwo en-aut-sei=Asano en-aut-mei=Kenwo kn-aut-name=浅野健夫 kn-aut-sei=浅野 kn-aut-mei=健夫 aut-affil-num=4 ORCID= en-aut-name=KageyamaHiroshi en-aut-sei=Kageyama en-aut-mei=Hiroshi kn-aut-name=影山浩 kn-aut-sei=影山 kn-aut-mei=浩 aut-affil-num=5 ORCID= en-aut-name=ShibuyaKoichi en-aut-sei=Shibuya en-aut-mei=Koichi kn-aut-name=渋谷貢一 kn-aut-sei=渋谷 kn-aut-mei=貢一 aut-affil-num=6 ORCID= en-aut-name=KotaniHidenari en-aut-sei=Kotani en-aut-mei=Hidenari kn-aut-name=小谷秀成 kn-aut-sei=小谷 kn-aut-mei=秀成 aut-affil-num=7 ORCID= en-aut-name=MatsuuraRyozo en-aut-sei=Matsuura en-aut-mei=Ryozo kn-aut-name=松浦良三 kn-aut-sei=松浦 kn-aut-mei=良三 aut-affil-num=8 ORCID= en-aut-name=TsuchidaJunichiro en-aut-sei=Tsuchida en-aut-mei=Junichiro kn-aut-name=土田潤一郎 kn-aut-sei=土田 kn-aut-mei=潤一郎 aut-affil-num=9 ORCID= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=10 ORCID= en-aut-name=HiraokaToshinobu en-aut-sei=Hiraoka en-aut-mei=Toshinobu kn-aut-name=平岡敏延 kn-aut-sei=平岡 kn-aut-mei=敏延 aut-affil-num=11 ORCID= en-aut-name=HimeiHajime en-aut-sei=Himei en-aut-mei=Hajime kn-aut-name=姫井孟 kn-aut-sei=姫井 kn-aut-mei=孟 aut-affil-num=12 ORCID= en-aut-name=MoritaniYoshiaki en-aut-sei=Moritani en-aut-mei=Yoshiaki kn-aut-name=守谷欣明 kn-aut-sei=守谷 kn-aut-mei=欣明 aut-affil-num=13 ORCID= en-aut-name=YamanaMasatoshi en-aut-sei=Yamana en-aut-mei=Masatoshi kn-aut-name=山名正俊 kn-aut-sei=山名 kn-aut-mei=正俊 aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=10 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=11 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=12 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=13 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=14 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1-3 article-no= start-page=213 end-page=231 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Cell-free Transmission of X-ray and 20-Methylcholanthrene-induced RF Mouse Leukemia kn-title=X線及び20-Methylcholanthreneにより惹起せしめたRF系マウス白血病の無細胞濾液移植に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Incidence of leukemia in RF mice exposed to a single whole body irradiation of 350 r X-rays was 77.4%, 41 out of 53 animals. Of them, 20 developed the thymic and other 20 the non-thymic lymphocytic leukemia, while only one developed myelogenous leukemia. Incidence of leukemia by 20-methylcholanthrene painting was 88%, 22 out of 25 animals. Of them, 12 developed lymphocytic leukemia and other 10 myelogenous leukemia. Experiments of inoculating cell-free filtrate prepared from these X-ray and 20-methylcholanthrene-induced leukemic RF mice revealed the following facts. 1) Cell-free filtrates from the leukemic mice which were induced by a single whole body X-irradiation were inoculated to the newborn mice of the same strain less than 16 hours old. Two (16.7%) of the twelve incculated animals developed leukemia 357 th and 374 th days, respectively, after the inoculation. Inoculation of the cell-free filtrates from normal mice to the newborn mice of the same strain did not produce leukemia. 2) Attempts to inoculate cell-free filtrate from 20-methylcholanthrene-indeced leukemic RF mice to newborn mice of the same strain were successful. 3) Cell-free filtrate from myelogenous leukemic mouse caused lymphocytic leukemia in one of three inoculated mice. This is suggestive of the possibility of transformation of the type of leukemia during cell-free transmission. 4) Intracerebral inoculation of cell-free filtrate from the brain of a mouse with lymphocytic leukemia also produced lymphocytic leukemia in one of two inoculated mice. 5) Inoculation of cell-free filtrate from the leukemic mice developed mammary carcinoma in one of three inoculated female mice. 6) Serial cell-free passage in two generations of 20-methylcholanthrene-induced leukemic mouse was possible. One of two inoculated mice developed leukemia in the first transmission and one of eight inoculated mice in the second transmission. 7) Only two cases of spontaneous lymphocytic leukemia were observed in RF mice during the past four years and the cell-free transmission of one leukemic mouse was also successful. 8) Virus-like particles were demonstrated by electron microscope in the lymph nodes of 20-methylcholanthrene-induced leukemic mouse. These facts suggest that the X-ray and chemical carcinogens may act to induce leukemia or mammary carcinoma by the "activation" of a latent virus naturally resident in the RF mouse. en-copyright= kn-copyright= en-aut-name=IrinoShozo en-aut-sei=Irino en-aut-mei=Shozo kn-aut-name=入野昭三 kn-aut-sei=入野 kn-aut-mei=昭三 aut-affil-num=1 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=2 ORCID= en-aut-name=OkadaKoichi en-aut-sei=Okada en-aut-mei=Koichi kn-aut-name=岡田耕一 kn-aut-sei=岡田 kn-aut-mei=耕一 aut-affil-num=3 ORCID= en-aut-name=MiyoshiIsao en-aut-sei=Miyoshi en-aut-mei=Isao kn-aut-name=三好勇夫 kn-aut-sei=三好 kn-aut-mei=勇夫 aut-affil-num=4 ORCID= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=5 ORCID= en-aut-name=KawamuraNorio en-aut-sei=Kawamura en-aut-mei=Norio kn-aut-name=川村範夫 kn-aut-sei=川村 kn-aut-mei=範夫 aut-affil-num=6 ORCID= en-aut-name=KunisadaMineo en-aut-sei=Kunisada en-aut-mei=Mineo kn-aut-name=国定岑生 kn-aut-sei=国定 kn-aut-mei=岑生 aut-affil-num=7 ORCID= en-aut-name=IkejiriKoji en-aut-sei=Ikejiri en-aut-mei=Koji kn-aut-name=池尻孝治 kn-aut-sei=池尻 kn-aut-mei=孝治 aut-affil-num=8 ORCID= en-aut-name=SatoMasanobu en-aut-sei=Sato en-aut-mei=Masanobu kn-aut-name=佐藤昌信 kn-aut-sei=佐藤 kn-aut-mei=昌信 aut-affil-num=9 ORCID= en-aut-name=SotaSusumu en-aut-sei=Sota en-aut-mei=Susumu kn-aut-name=宗田範 kn-aut-sei=宗田 kn-aut-mei=範 aut-affil-num=10 ORCID= en-aut-name=SuzakiMasanori en-aut-sei=Suzaki en-aut-mei=Masanori kn-aut-name=須崎正則 kn-aut-sei=須崎 kn-aut-mei=正則 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=8-9 article-no= start-page=819 end-page=822 dt-received= dt-revised= dt-accepted= dt-pub-year=1962 dt-pub=19620930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Remote Results of Epidemic Hepatitis On the Prevalence of Epidemic Hepatitis at Kagato-Cho, Wake-Gun, Okayama kn-title=流行性肝炎の遠隔成績（和気郡香登町の流行について） en-subtitle= kn-subtitle= en-abstract= kn-abstract=A thourough examination was performed on the 319 cases, passed for more than one year after the release of treatment under the diagnosis of recovery or after the suspension of treatment at Kagato-Cho, Wake-Gun, Okayama in where there were prevalence of mild abortive form of epidemic hepatitis. 1. The cases having subjective symptom were 201 caces (63.0%) and their complaints were mainly the same to those on the course of disease. 2. Hepatomegaly in 77 cases (21.0%) and splenomegaly in 7 cases (2.2%) were ebserved. 3. Cases showing impairment in liver function test were 5.6-10.3% and cases showing a mild hyperbilirubinemia were 10 cases. 4. From the above results, cases required of treatment were 7 (2.2%), cases required of care 36 cases (11.3%). The concept that recovery of epidemic hepatitis was difficults was supported with the above results. 5. In the epidemics patients being required of treatment consisted of the second and third decades. 6. Duriug the last seven years, 1957 to 1963, 67 (21.3%) out of 314 cases of infections hepatitis in the epidemic areas developed into chronic hepatitis. 7. Acute stage of hepatitis at the onset was classified into three forms; typical, abortive and subclinical ones. 40.4% of the typical, 22.7% of the abortive and 36.2% of subclinical form progressed into chronic stage. Attention should be drawn to the high percentage of chronisity from the subclinical form of infectious hepatitis. en-copyright= kn-copyright= en-aut-name=KosakaKiyowo en-aut-sei=Kosaka en-aut-mei=Kiyowo kn-aut-name=小坂淳夫 kn-aut-sei=小坂 kn-aut-mei=淳夫 aut-affil-num=1 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=2 ORCID= en-aut-name=YamamotoShigeru en-aut-sei=Yamamoto en-aut-mei=Shigeru kn-aut-name=山本繁 kn-aut-sei=山本 kn-aut-mei=繁 aut-affil-num=3 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=4 ORCID= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=5 ORCID= en-aut-name=ShinoharaToshio en-aut-sei=Shinohara en-aut-mei=Toshio kn-aut-name=篠原敏夫 kn-aut-sei=篠原 kn-aut-mei=敏夫 aut-affil-num=6 ORCID= en-aut-name=UedaUtaka en-aut-sei=Ueda en-aut-mei=Utaka kn-aut-name=植田胖 kn-aut-sei=植田 kn-aut-mei=胖 aut-affil-num=7 ORCID= en-aut-name=AsadaKiyotaka en-aut-sei=Asada en-aut-mei=Kiyotaka kn-aut-name=浅田清隆 kn-aut-sei=浅田 kn-aut-mei=清隆 aut-affil-num=8 ORCID= en-aut-name=KajiMasayoshi en-aut-sei=Kaji en-aut-mei=Masayoshi kn-aut-name=加地正義 kn-aut-sei=加地 kn-aut-mei=正義 aut-affil-num=9 ORCID= en-aut-name=EndoKenichi en-aut-sei=Endo en-aut-mei=Kenichi kn-aut-name=遠藤憲一 kn-aut-sei=遠藤 kn-aut-mei=憲一 aut-affil-num=10 ORCID= en-aut-name=AisakaTadakazu en-aut-sei=Aisaka en-aut-mei=Tadakazu kn-aut-name=相坂忠一 kn-aut-sei=相坂 kn-aut-mei=忠一 aut-affil-num=11 ORCID= en-aut-name=TakagaiNaoteru en-aut-sei=Takagai en-aut-mei=Naoteru kn-aut-name=高木直輝 kn-aut-sei=高木 kn-aut-mei=直輝 aut-affil-num=12 ORCID= en-aut-name=KobashiNobuo en-aut-sei=Kobashi en-aut-mei=Nobuo kn-aut-name=小橋暢夫 kn-aut-sei=小橋 kn-aut-mei=暢夫 aut-affil-num=13 ORCID= en-aut-name=KitagawaYukinori en-aut-sei=Kitagawa en-aut-mei=Yukinori kn-aut-name=北川紀典 kn-aut-sei=北川 kn-aut-mei=紀典 aut-affil-num=14 ORCID= en-aut-name=NukataKaname en-aut-sei=Nukata en-aut-mei=Kaname kn-aut-name=額田要 kn-aut-sei=額田 kn-aut-mei=要 aut-affil-num=15 ORCID= en-aut-name=OnoNobuhiro en-aut-sei=Ono en-aut-mei=Nobuhiro kn-aut-name=小野延宏 kn-aut-sei=小野 kn-aut-mei=延宏 aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=13 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=14 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=15 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=16 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=5-6 article-no= start-page=795 end-page=835 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Morphology and Classification of Oncogenic Viruses kn-title=腫瘍ウイルスの形態と分類 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Morphologic characteristics of most of known oncogenic viruses, some of which were investigated by us, were described in relation to their oncogenicity and their localizations in tumor tissues. Oncogenic viruses were classified into six groups: type A, B, C, D, E and F. Viruses pertaining to type A were presumably not mature virus particles. Some of them could, however, be immature form or incomplete form of oncogenic virus particles. Viruses belonging to type B, C, D, E, and F were represented by mammary tumor virus of mice, leukemia viruses of mice and chickens, polyoma virus, Shope fibroma virus and Lucke renal adenocarcinoma virus, respectively. They were different in size and shape, and in the mode of development. It was presumed that type B and C viruses were members of the Myxovisus group and type D viruses belonged to Adenovirus and the Papova virus group. It was also believed that type E and F viruses had in general the feature of the Pox virus group and Herpes virus group, respectively. en-copyright= kn-copyright= en-aut-name=HirakiKiyoshi en-aut-sei=Hiraki en-aut-mei=Kiyoshi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=2 ORCID= en-aut-name=IrinoShozo en-aut-sei=Irino en-aut-mei=Shozo kn-aut-name=入野昭三 kn-aut-sei=入野 kn-aut-mei=昭三 aut-affil-num=3 ORCID= en-aut-name=MiyoshiIsao en-aut-sei=Miyoshi en-aut-mei=Isao kn-aut-name=三好勇夫 kn-aut-sei=三好 kn-aut-mei=勇夫 aut-affil-num=4 ORCID= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=SuzukiShinya en-aut-sei=Suzuki en-aut-mei=Shinya kn-aut-name=鈴木信也 kn-aut-sei=鈴木 kn-aut-mei=信也 aut-affil-num=7 ORCID= en-aut-name=OhsatoYoshimori en-aut-sei=Ohsato en-aut-mei=Yoshimori kn-aut-name=大里尚司 kn-aut-sei=大里 kn-aut-mei=尚司 aut-affil-num=8 ORCID= en-aut-name=NagamoriTeiichiro en-aut-sei=Nagamori en-aut-mei=Teiichiro kn-aut-name=永森俤一郎 kn-aut-sei=永森 kn-aut-mei=俤一郎 aut-affil-num=9 ORCID= en-aut-name=MoriyaJunichiro en-aut-sei=Moriya en-aut-mei=Junichiro kn-aut-name=守屋純一郎 kn-aut-sei=守屋 kn-aut-mei=純一郎 aut-affil-num=10 ORCID= en-aut-name=MugurumaMasahito en-aut-sei=Muguruma en-aut-mei=Masahito kn-aut-name=六車昌士 kn-aut-sei=六車 kn-aut-mei=昌士 aut-affil-num=11 ORCID= en-aut-name=TakasugiKiyoshi en-aut-sei=Takasugi en-aut-mei=Kiyoshi kn-aut-name=高杉潔 kn-aut-sei=高杉 kn-aut-mei=潔 aut-affil-num=12 ORCID= en-aut-name=DabasakiHiroshi en-aut-sei=Dabasaki en-aut-mei=Hiroshi kn-aut-name=駄場崎浩 kn-aut-sei=駄場崎 kn-aut-mei=浩 aut-affil-num=13 ORCID= en-aut-name=IkedaKazuhiko en-aut-sei=Ikeda en-aut-mei=Kazuhiko kn-aut-name=池田一彦 kn-aut-sei=池田 kn-aut-mei=一彦 aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 affil-num=2 en-affil= kn-affil=岡山大学平木内科 affil-num=3 en-affil= kn-affil=岡山大学平木内科 affil-num=4 en-affil= kn-affil=岡山大学平木内科 affil-num=5 en-affil= kn-affil=岡山大学平木内科 affil-num=6 en-affil= kn-affil=岡山大学平木内科 affil-num=7 en-affil= kn-affil=岡山大学平木内科 affil-num=8 en-affil= kn-affil=岡山大学平木内科 affil-num=9 en-affil= kn-affil=岡山大学平木内科 affil-num=10 en-affil= kn-affil=岡山大学平木内科 affil-num=11 en-affil= kn-affil=岡山大学平木内科 affil-num=12 en-affil= kn-affil=岡山大学平木内科 affil-num=13 en-affil= kn-affil=岡山大学平木内科 affil-num=14 en-affil= kn-affil=岡山大学平木内科 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=3-4 article-no= start-page=297 end-page=303 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Therapeutic and Prophylactic Effect of α-MercaptopropionylGlycine for Toxicity of Mercury and its Compounds (Part 1. Studies on Excretion of Mercury by α-MercaptopropionylGlycine and Penicillamine on the Workers Using Mercury Compound) kn-title=水銀中毒に対するα-Mercaptopropionyl glycine及びD-Penicillamineの水銀排泄効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A therapeutic and prophylactic effect of α-mercaptopropionyl glycine for toxicity of mercury and its compounds was tested in comparison with the effect of D-penicillamine. The nine subjects working in an industrial factory manufacturing insecticides made from mercury were selected for the investigation. The daily dosis of α-mercaptopropionyl glycine was 450mg and it was 1000mg of D-penicillamine. The results obtaind were as follows: 1. The average daily excretion of mercury in urine was increased 1.4 to 1.6 times (average, 1.5 times) of the amount estimated before the administration when the subjects were in exposure of mercury. The increase was more than that obtained with the use of D-penicillamine (average, 1.2 times). 2. The average daily excretion of mercury in urine was increased 2 to 3 times of the amount estimated before the administration when the urinary excretion of mercury was determined after the exposure. The increase was lasted as long as 12 days after the discontinuation of the exposure. α-Mercaptopropionyl glycine was proved to be more effective than D-penicillamine when it was tested serially in a same subject. 3. From the results obtained here, it was concluded that the administration of α-mercap-topropionyl glycine at the daily dosis of 450mg was proved to be effective for the prophylaxis of mercury toxicity. It was especially true when the sujects were working in the exposure of mercury, therefore, it was recommended to use α-mercaptopropionyl glycine as long as the increase of urinary excretion of mercury was no more observed. 4. During the administration, there observed no appreciable side effects, and so the prophylactic use of α-mercaptopropionyl glycine was proved to be not hazardous. en-copyright= kn-copyright= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=緒方正名 kn-aut-sei=緒方 kn-aut-mei=正名 aut-affil-num=1 ORCID= en-aut-name=EguchiYoshinosuke en-aut-sei=Eguchi en-aut-mei=Yoshinosuke kn-aut-name=江口嘉之助 kn-aut-sei=江口 kn-aut-mei=嘉之助 aut-affil-num=2 ORCID= en-aut-name=KinamiTomikichi en-aut-sei=Kinami en-aut-mei=Tomikichi kn-aut-name=木南富吉 kn-aut-sei=木南 kn-aut-mei=富吉 aut-affil-num=3 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部小坂内科教室 END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=11-12 article-no= start-page=1551 end-page=1559 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19791230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pre and post operative changes in lymphocyte mediated cytotoxicity and serum blocking factor on human colon cancer kn-title=大腸癌患者における術前術後のリンパ球殺細胞性および血清阻止因子の変動について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Lymphocyte-mediated cytotoxicity and serum blocking factor, their classification according to the stage, and the follow-up observations before and after operation were investigated in 40 cases of colon cancer. For the control group, the cytotoxicity test was conducted on 12 cases of cancer other than colon cancer. Cytotoxicity was detected in only one of these. Cytotoxicity was detected in 30 cases of colon cancer. There were no significant differences due to the stage of cancer. Serum blocking factor was investigated in 34 cases and 25 of them showed positive blocking. Classification by stage showed tendency for the blocking index to increase with advance of the cancer. Follow-up observations before and after operation were conducted on 14 cases. The cytotoxicity, rose transiently after operation then decreased progressively in cases undergoing therapeutic surgery. Cytotoxicity reappeared in the cases of recurrence. The serum blocking factor decreased after operation showing transient negative blocking, then disappeared. In the cases of non-curative surgery, cytotoxicity rose transiently after operation and did not disappear throughout the entire course of observation. Serum blocking factor after operation showed transient negative blocking, then returned to positive. en-copyright= kn-copyright= en-aut-name=OhtaTamotsu en-aut-sei=Ohta en-aut-mei=Tamotsu kn-aut-name=太田保 kn-aut-sei=太田 kn-aut-mei=保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 en-keyword=lymphocytotoxicity kn-keyword=lymphocytotoxicity en-keyword=blocking factor kn-keyword=blocking factor END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=9-10 article-no= start-page=805 end-page=812 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19821030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=β(2)-Microglobulin in saliva and serum from patients with Sjogren's syndrome kn-title=シェーグレン病における唾液・血清β(2)ミクログロブリン値 en-subtitle= kn-subtitle= en-abstract= kn-abstract=β(2)-microglobulin is normally present in low concentrations in serum and other bodily fluids. By use of a radioimmunoassay, we measured salivary and serum β(2)-microglbulin concentrations in 40 patients with Sjogren's syndrome. The β(2)-microglobulin was significantly elevated in the saliva of patients with Sjogren's syndrome (p<0.005), but not in the serum. It was also elevated in the saliva of patients who had severe inflammatory change in the minor salivary gland, abnormal sialographic findings, reduced salivary flow rate and anti SS-A or SS-B antibody in their sera. There was no relation between the salivary , β(2)-microglobulin concentrations and the presence of various autoimmune diseases associated with Sjogren's syndrome. Measurement of salivary β(2)-microglobulin may offer a simple method of quantifying local activity in Sjogren's syndrome. en-copyright= kn-copyright= en-aut-name=NambaYoshio en-aut-sei=Namba en-aut-mei=Yoshio kn-aut-name=難波義夫 kn-aut-sei=難波 kn-aut-mei=義夫 aut-affil-num=1 ORCID= en-aut-name=KageyamaKeiko en-aut-sei=Kageyama en-aut-mei=Keiko kn-aut-name=景山ケイコ kn-aut-sei=景山 kn-aut-mei=ケイコ aut-affil-num=2 ORCID= en-aut-name=AzukizawaHideo en-aut-sei=Azukizawa en-aut-mei=Hideo kn-aut-name=小豆沢秀夫 kn-aut-sei=小豆沢 kn-aut-mei=秀夫 aut-affil-num=3 ORCID= en-aut-name=MiyawakiShoji en-aut-sei=Miyawaki en-aut-mei=Shoji kn-aut-name=宮脇昌二 kn-aut-sei=宮脇 kn-aut-mei=昌二 aut-affil-num=4 ORCID= en-aut-name=OhtaZensuke en-aut-sei=Ohta en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=5 ORCID= en-aut-name=OfujiTadashi en-aut-sei=Ofuji en-aut-mei=Tadashi kn-aut-name=大藤眞 kn-aut-sei=大藤 kn-aut-mei=眞 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=4 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=5 en-affil= kn-affil=岡山大学医学部第三内科 affil-num=6 en-affil= kn-affil=岡山大学学長 en-keyword=Sjögren's syndrome kn-keyword=Sjögren's syndrome en-keyword=β(2)-microglobulin kn-keyword=β(2)-microglobulin END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=11-12 article-no= start-page=1111 end-page=1114 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19861230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ultrastructure of the rat glomerular basement membrane after enzymatic digestion kn-title=酵素処理によるラット腎糸球体基底膜の微細構造の観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although various hypotheses have been proposed about the ultrastructure of the glomerular basement membrane (GBM) of the kidney, it has not clearly revealed. At present, it is thought to be composed of a meshwork of fibrils as reported by Ota et al. We successfully observed the meshwork structure of the GBM under an electron microscope after enzymatic treatment with α-amylase and elastase. The fibrils were about 30nm in width and were thought to be composed of type Ⅳ collagen. en-copyright= kn-copyright= en-aut-name=IchiyasuAkira en-aut-sei=Ichiyasu en-aut-mei=Akira kn-aut-name=一安朗 kn-aut-sei=一安 kn-aut-mei=朗 aut-affil-num=1 ORCID= en-aut-name=TakaokaMichio en-aut-sei=Takaoka en-aut-mei=Michio kn-aut-name=高岡道夫 kn-aut-sei=高岡 kn-aut-mei=道夫 aut-affil-num=2 ORCID= en-aut-name=TakahashiKayo en-aut-sei=Takahashi en-aut-mei=Kayo kn-aut-name=高橋香代 kn-aut-sei=高橋 kn-aut-mei=香代 aut-affil-num=3 ORCID= en-aut-name=OtaZenske en-aut-sei=Ota en-aut-mei=Zenske kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学第三内科 affil-num=2 en-affil= kn-affil=岡山大学第三内科 affil-num=3 en-affil= kn-affil=岡山大学第三内科 affil-num=4 en-affil= kn-affil=岡山大学第三内科 en-keyword=glomerular basement membrane kn-keyword=glomerular basement membrane en-keyword=enzymatic digestion kn-keyword=enzymatic digestion en-keyword=ultrastructure kn-keyword=ultrastructure en-keyword=type Ⅳ collagen kn-keyword=type Ⅳ collagen END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=3-4 article-no= start-page=233 end-page=241 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Life style and health status of the aged in a rural areaPart 2. Actual status by family type kn-title=農村地域における老年者の生活構造と健康状態 第2報 家族構成別状況について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Problems in life styles and health status according to family type and the presence or lack of a spouse among the aged in a rural area were investigated. The subjects were all residents of 65 or over who lived at home in Ohgata Town, Kochi Prefecture, in March of 1982. Responses to the questionnaire survey were obtained from 1,545 (92.5%) out of 1,671. The subjects were divided into three groups of family type, that is, "single", "couple" and "other", and into two groups by marital status, that is, "married" and "not married". The perceived health status of "single" subjects was not different from that of "other" subjects, but those requiring help in activities of daily living (ADL) were less among "single" than among "other" females. Also, the perceived health of "couples" was worse than that of "others" among males. No differences were observed in the rate of those with work among the three groups of family types. Those joining in group activities were fewer, but not significantly, so among "single" men than among men of the other two groups, but no differences were observed among females. The perceived health status of "married" males were worse than that of the "unmarried" males, but no differences were observed among females. Those with work were greater among "married" than "unmarried" subjects of both sexes, and those having a role at home were greater among "married" than "unmarried" females. No differences were observed in the rate of joining in group activities or health practices between "married" and "unmarried" subjects. These findings demonstrated that family patterns played the same important role in the health and welfare needs of aged people as age factors. en-copyright= kn-copyright= en-aut-name=OharaHiroshi en-aut-sei=Ohara en-aut-mei=Hiroshi kn-aut-name=大原啓志 kn-aut-sei=大原 kn-aut-mei=啓志 aut-affil-num=1 ORCID= en-aut-name=HorikawaShunichi en-aut-sei=Horikawa en-aut-mei=Shunichi kn-aut-name=堀川俊一 kn-aut-sei=堀川 kn-aut-mei=俊一 aut-affil-num=2 ORCID= en-aut-name=HisashigeAkinori en-aut-sei=Hisashige en-aut-mei=Akinori kn-aut-name=久繁哲徳 kn-aut-sei=久繁 kn-aut-mei=哲徳 aut-affil-num=3 ORCID= en-aut-name=HatadaKazunori en-aut-sei=Hatada en-aut-mei=Kazunori kn-aut-name=畑田一憲 kn-aut-sei=畑田 kn-aut-mei=一憲 aut-affil-num=4 ORCID= en-aut-name=SuzukiJunichiro en-aut-sei=Suzuki en-aut-mei=Junichiro kn-aut-name=鈴木順一郎 kn-aut-sei=鈴木 kn-aut-mei=順一郎 aut-affil-num=5 ORCID= en-aut-name=YoshidaTakeo en-aut-sei=Yoshida en-aut-mei=Takeo kn-aut-name=吉田健男 kn-aut-sei=吉田 kn-aut-mei=健男 aut-affil-num=6 ORCID= en-aut-name=ItaniToru en-aut-sei=Itani en-aut-mei=Toru kn-aut-name=井谷徹 kn-aut-sei=井谷 kn-aut-mei=徹 aut-affil-num=7 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=8 ORCID= en-aut-name=AoyamaHideyasu en-aut-sei=Aoyama en-aut-mei=Hideyasu kn-aut-name=青山英康 kn-aut-sei=青山 kn-aut-mei=英康 aut-affil-num=9 ORCID= en-aut-name=OhiraMasahiko en-aut-sei=Ohira en-aut-mei=Masahiko kn-aut-name=大平昌彦 kn-aut-sei=大平 kn-aut-mei=昌彦 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=高知医科大学公衆衛生学教室 affil-num=2 en-affil= kn-affil=高知医科大学公衆衛生学教室 affil-num=3 en-affil= kn-affil=高知医科大学公衆衛生学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部衛生学教室 en-keyword=the aged kn-keyword=the aged en-keyword=family type kn-keyword=family type en-keyword=life style kn-keyword=life style en-keyword=health status kn-keyword=health status en-keyword=rural area kn-keyword=rural area END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=3-4 article-no= start-page=219 end-page=231 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Life style and health status of the aged in a rural area Part 1. Actual status by age kn-title=農村地域における老年者の生活構造と健康状態 第1報 年齢階級別状況について en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated changes in life styles and health problems among the aged population in a rural area by means of a questionnaire differentiated as to age. Responses were obtained from 1,545 (92.5%) out of 1,671 people 65 years of age or over living in Ohgata Town, Kochi Prefecture, in March of 1982. Two hundred people in hospitals or nursing homes were excluded from the survey. Among the aged of Ohgata, 1.6% and 9.0% were living in hospitals or nursing homes, respectively. Those in the hospitals increased with increasing age. Five percent of the males and 22.8% of the females lived alone, and no difference was observed according to age group. Sixty percent of the males and 80.2% of the females had jobs or roles at home, and significant decreases in those with roles were observed from 70 and 80 years of age or over in males, and between any successive 5-year age group in females. Seventy-seven percent of the respondents met with their friends, and 57.3% joined in the activities of old peoples' clubs. These rates decreased steeply from 80 or over in males and 85 or over in females. About the perceived health status, 54.9% of males and 51.3% of females had no complaints and those without preblems decreased slowly with increasing age. Those who needed others' help in any of the activities of daily life such as eating, going to the toilet, bathing, dressing, washing the face or walking were 6.3% of males and 6.6% of females, and were over 20% among those 85 or over. Those with troubles in walking but without troubles in other activities were 7.2%, increasing steeply from 80 or over. These findings demonstrated that age factors had important impacts on the health and welfare needs of aged. en-copyright= kn-copyright= en-aut-name=OharaHiroshi en-aut-sei=Ohara en-aut-mei=Hiroshi kn-aut-name=大原啓志 kn-aut-sei=大原 kn-aut-mei=啓志 aut-affil-num=1 ORCID= en-aut-name=HorikawaShunichi en-aut-sei=Horikawa en-aut-mei=Shunichi kn-aut-name=堀川俊一 kn-aut-sei=堀川 kn-aut-mei=俊一 aut-affil-num=2 ORCID= en-aut-name=HisashigeAkinori en-aut-sei=Hisashige en-aut-mei=Akinori kn-aut-name=久繁哲徳 kn-aut-sei=久繁 kn-aut-mei=哲徳 aut-affil-num=3 ORCID= en-aut-name=HatadaKazunori en-aut-sei=Hatada en-aut-mei=Kazunori kn-aut-name=畑田一憲 kn-aut-sei=畑田 kn-aut-mei=一憲 aut-affil-num=4 ORCID= en-aut-name=SuzukiJunichiro en-aut-sei=Suzuki en-aut-mei=Junichiro kn-aut-name=鈴木順一郎 kn-aut-sei=鈴木 kn-aut-mei=順一郎 aut-affil-num=5 ORCID= en-aut-name=YoshidaTakeo en-aut-sei=Yoshida en-aut-mei=Takeo kn-aut-name=吉田健男 kn-aut-sei=吉田 kn-aut-mei=健男 aut-affil-num=6 ORCID= en-aut-name=ItaniToru en-aut-sei=Itani en-aut-mei=Toru kn-aut-name=井谷徹 kn-aut-sei=井谷 kn-aut-mei=徹 aut-affil-num=7 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=8 ORCID= en-aut-name=AoyamaHideyasu en-aut-sei=Aoyama en-aut-mei=Hideyasu kn-aut-name=青山英康 kn-aut-sei=青山 kn-aut-mei=英康 aut-affil-num=9 ORCID= en-aut-name=OhiraMasahiko en-aut-sei=Ohira en-aut-mei=Masahiko kn-aut-name=大平昌彦 kn-aut-sei=大平 kn-aut-mei=昌彦 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=高知医科大学公衆衛生学教室 affil-num=2 en-affil= kn-affil=高知医科大学公衆衛生学教室 affil-num=3 en-affil= kn-affil=高知医科大学公衆衛生学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部衛生学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部衛生学教室 en-keyword=the aged kn-keyword=the aged en-keyword=aging kn-keyword=aging en-keyword=life style kn-keyword=life style en-keyword=health status kn-keyword=health status en-keyword=rural area kn-keyword=rural area END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=2 article-no= start-page=149 end-page=157 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study on actual conditions of care for the elderly in urban and rural areas of Okayama prefecture kn-title=岡山県の都市部･農村部における高齢者の在宅ケアの実態 en-subtitle= kn-subtitle= en-abstract=The purpose of this study is to demonstrate the actual condition of care for the elderly, especially to make clear the difference between urban and rural areas of Okayama prefecture in which the rate of aging (16.9%) is higher than that of the whole country (14.1%). A survey distributed by municipal employees such as public health nurses and homehelpers, was done in the prefectural capital (Okayama) which was used for the urban aera study and one small city (Takahashi) and two towns (Oku and Kumenan) which were used for the rural areas study groups from August through September, 1995. The rate of persons cared for at home was low in the rural areas compared to that in the urban area, namely many persons were cared for at faclities for elderly or at hospitals. Date obtained from 140 families, 39 in the rural area and 101 in the urban areas respectively, were analysed. Persons cared for at home were generally old. 77.1% of them was older than 75 years of age and they suffered from many disorder. The period of care was quite long in the depopulated area, as 63% of them were cared for more than 5 years and one third of persons caring for them were more than 70 years of age. In the rural area, more than half of the elderly were cared for by their spouses. The time spent in helping them bathe and change their clothes was lower in the rural area than in the urban area. The time perdiem spent caring by each family was 3 hours in the rural area, while 7 hours in the urban area. The rate of persons who utilized visiting nurses was high in urban area, while homehelpers were high in the rural areas. The utilization of non-governmental services was low in both areas. The author concludes that care for the elderly in the rural areas is actually difficult and poor in quality compared to that in the rural aera. kn-abstract=高齢者の在宅ケアの必要性が増大している一方,女性の就労者の増加や核家族化は在宅でのケアを困難にしている。そこで,実際にどのような現状や問題があるのかを検討する必要があると考えた｡今回,全国の高齢化率(14.1%)より高い高齢化率(16.9%)の岡山県で,在宅ケアの実態を1995年8月から9月にかけて調査した｡都市部(岡山市)･農村部(高梁市･邑久町･久米南町)で比較すると,在宅ケアは都市部に比べ農村部が少なく,農村部では施設での介護の方が多いことを認めた｡分析対象は140名で都市部が39名,農村部が101名である｡在宅でケアを受ける75歳以上の高齢者は77.1%と多かった｡農村部の方が高年齢で障害度も重く,特に過疎地域では介護期間も長く5年以上が過半数を占めていた｡主たる介護者は都市部では配偶者が63%と多かった｡過疎の農村部では息子の妻および孫の妻が多く,また70歳以上の高齢の介護者が3分の1を占めていた｡入浴･更衣回数などのケア回数は県北の農村部では特に少なかった｡また家族の介護時間は都市部は1日につき約7時間であったが,農村部では約3時間のみであった｡保健婦･看護婦などの専門職者によるサービスは都市部に多く,ホームヘルパーによるサービスは農村部に多かった。民間のサービス利用率は都市部･農村部いづれも低かった｡以上のごとく農村部における高齢者の介護がより問題が多く,深刻な状況であることが明らかになった｡ en-copyright= kn-copyright= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=高齢者 (the elderly) kn-keyword=高齢者 (the elderly) en-keyword=在宅ケア (home care) kn-keyword=在宅ケア (home care) en-keyword=都市部 (urban area) kn-keyword=都市部 (urban area) en-keyword=農村部 (rural area) kn-keyword=農村部 (rural area) en-keyword=岡山県 (Okayama prefecture) kn-keyword=岡山県 (Okayama prefecture) END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=2 article-no= start-page=113 end-page=120 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Senior high school students' recognition and interest in allied medical education of college kn-title=医療技術教育に対する高校生の認識と関心に関する研究 en-subtitle= kn-subtitle= en-abstract=A survey was carried out by senior high school students in Okayama and nine surrounding prefectures from July through September, 1996. Data obtained from 1998 twelfth-grade students studying general courses at 52 schools were computed. Eighty four percent of the 891 male students and 54.2% of the 1,077 female students wished to go on to senior college. Sixtyseven percent of the male students wished to enter science college courses, while only 25.8% of female students did. The rate of students who knew about the course of allied medical science in senior or junior colleges was 63.8% for male students and 82.5% for female students. The nursing course was popular among both sexes, but other courses such as radiological technology, medical technology, physical therapy and occupational therapy were not well known, especially among male students. It was thought that students wishing to go on to the senior college were not interested in those areas which were usually taught in three year courses at junior colleges or special (vocational) schools. Accordingly, the data showed that their interests in the allied medical course would be increased by the shifting it to a four year course. To attract senior high school students who are both intelligent and talented in the medical and health field, the authors concluded that the further improvement of educational course for allied medicine, especially such as shifting to a four year course, and the bettering of position of comedical workers through it are needed. kn-abstract=1996年7～9月にかけて,岡山県周辺の10県下高校普通科3年在学中の学生に志望進路,志望分野とともに大学,短期大学における医療技術教育への認識と関心についてアンケート調査を行った｡サンプリングによって依頼した127校のうち回答が得られたのは52校(回収率40.9%)で,得られた回答数は合計1,998人(男子891人,女子1,077人,不明30人)であった｡これらの分析から,これらの地域では進学志望者の率は高く,特に男子に著名で,男女ともに理系への志望が多いことを認めた｡医療技術系大学の認識は看護学科を除いて低く,関心も特に男子で低かった｡4年制大学の進学を志望する学生にとっては, 3年制の多い医療技術系短期大学には関心が寄せがたく, 4年制へ移行した場合には関心も志望も高まる事が認められた｡将来この分野を担う人材の確保には現在の医療短大の4年制化や医療技術職の待遇改善が重要である と結論づけた｡ en-copyright= kn-copyright= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=1 ORCID= en-aut-name=ShimoishiYasuaki en-aut-sei=Shimoishi en-aut-mei=Yasuaki kn-aut-name=下石靖昭 kn-aut-sei=下石 kn-aut-mei=靖昭 aut-affil-num=2 ORCID= en-aut-name=KageyamaJingo en-aut-sei=Kageyama en-aut-mei=Jingo kn-aut-name=景山甚郷 kn-aut-sei=景山 kn-aut-mei=甚郷 aut-affil-num=3 ORCID= en-aut-name=ShibuyaKoichi en-aut-sei=Shibuya en-aut-mei=Koichi kn-aut-name=渋谷光一 kn-aut-sei=渋谷 kn-aut-mei=光一 aut-affil-num=4 ORCID= en-aut-name=TohgeHiroko en-aut-sei=Tohge en-aut-mei=Hiroko kn-aut-name=唐下博子 kn-aut-sei=唐下 kn-aut-mei=博子 aut-affil-num=5 ORCID= en-aut-name=EndoHiroshi en-aut-sei=Endo en-aut-mei=Hiroshi kn-aut-name=遠藤浩 kn-aut-sei=遠藤 kn-aut-mei=浩 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部 en-keyword=医療技術教育 (the allied medical education) kn-keyword=医療技術教育 (the allied medical education) en-keyword=高校生 (senior high school students) kn-keyword=高校生 (senior high school students) en-keyword=短期大学 (junior college) kn-keyword=短期大学 (junior college) en-keyword=大学 (college) kn-keyword=大学 (college) en-keyword=進学 (high school students wishing to go on to college) kn-keyword=進学 (high school students wishing to go on to college) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=85 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nursing students' images of the elderly before and after a two-week nursing practice kn-title=看護学生の老人施設実習前後の老人イメージ en-subtitle= kn-subtitle= en-abstract=This study investigated how nursing students perceived the elderly living in a nursing home for the elderly. Testing was done both before and after they experienced a two-week nursing practice at the nursing home. Three findings were obtained. (1) The students regarded the elderly not only as more humorous and vital but also less experienced, peaceful, and realistic before than after experiencing the practice. (2) Over a third of the students named humorous/not humorous as an item for which they experienced a marked change in image of the elderly. (3) The students generally regarded the elderly as being experienced, warm, bored, weak, and lonely. The findings indicate that the nursing practice provided the students with an opportunity to form better and realistic images of the elderly. kn-abstract=2週間の特別養護老人ホームの実習前及び実習後の学生の老人イメージを20項目の尺度を用いて調査した｡その結果,以下のことが明らかになった｡ 1. 実習後のイメージの平均得点は,｢ユーモアのない｣から｢ユーモアのある｣へ,｢生気のない｣から｢生気のある｣へと好ましい方向へ上昇し,一方｢経験に富む｣,｢穏やかな｣,｢現実的な｣は好ましくない方向へ変化した｡ 2. 3分の1以上の学生が実習後に特にイメージが変化した項目として｢ユーモアのない/ユーモアのある｣の項目をあげた｡ 3. 老人像は全体として｢暇な｣,｢弱い｣,｢孤独な｣という否定的な老人イメージと｢経験に富む｣,｢暖かい｣という肯定的イメージで捉えられており,このイメージは実習前後で共通していた｡実習前後では全体として老人像に大きな変化はなかったものの,実習によって,より活動的な老人イメージを抱き,より現実的に老人をとらえていることが明らかになり,A園での老人看護学実習は教育上意義のある実習であると評価した｡ en-copyright= kn-copyright= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=渡辺久美 kn-aut-sei=渡辺 kn-aut-mei=久美 aut-affil-num=1 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=2 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=3 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=4 ORCID= en-aut-name=MaedaMakiko en-aut-sei=Maeda en-aut-mei=Makiko kn-aut-name=前田真紀子 kn-aut-sei=前田 kn-aut-mei=真紀子 aut-affil-num=5 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=老人 (elderly) kn-keyword=老人 (elderly) en-keyword=イメージ (images) kn-keyword=イメージ (images) en-keyword=看護学生 (nursing students) kn-keyword=看護学生 (nursing students) en-keyword=看護実習 (nursing practice) kn-keyword=看護実習 (nursing practice) en-keyword=看護教育 (nursing education) kn-keyword=看護教育 (nursing education) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=77 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Food intake and nutrients intake of nursing student. kn-title=看護学生の食品摂取量と栄養摂取状況 en-subtitle= kn-subtitle= en-abstract=A questionnaire survey on daily food intake was conducted to assess the food intake,the nutritional intake and fulfilling rate of nutrients in 145 second-years students of School of Health Sciences, Okayama University, in 1993 and 1994. The following results were obtained. 1. The mean fulfilling rate was low for dietary fiber, while it was high for vitamin A and vitamin C. 2. There were low correlation between the number of foods and any specific nutrient. Intakes of energy,iron, Vitamin C and salt were significantly higher in students taking a large number of foods than those taking a small number of foods. 3. There was a correlation between the intake of dietary fiber and that of vitamin A. Students with a low fulfilling rate of dietary fiber tended to have low fulfilling rate of calcium and iron. 4. There were no differences between students living with their parents and those living alone. Food intake should be decided effectively to correct nutritional imbalance in students. It is necessary to inform young people how to form dietary habits corresponding to their taste and life-style. kn-abstract=1993年及び1994年度の本短期大学部看護学科の2年次生145名を対象に, 1日の摂取食品調査を行い,摂取食品数,栄養摂取量,栄養素等充足率を求めた。これらの分析の結果,以下の結論を得た。1.全体の平均充足率のバランスは,食物繊維が低く,ビタミンA,ビタミンCが高い値を示した。2.摂取食品数と栄養素等との相関は低かったが,食品数を2群に分けて比較すると,食品数多群でエネルギー,鉄,ビタミンC,食塩の摂取量が有意に多かった。3.充足率の低かった食物繊維とビタミンAは相関があり,また食物繊維の充足率の低い学生は,カルシウム,鉄の充足率が低い傾向にあった。4.自宅生と下宿生の比較では,差は見られなかった｡これらの改善には,栄養素等の不足を効果的に補える食品の選択や,若い世代の嗜好や生活にあった食習慣形成のための情報提供が必要である｡ en-copyright= kn-copyright= en-aut-name=HoshinaEiko en-aut-sei=Hoshina en-aut-mei=Eiko kn-aut-name=保科英子 kn-aut-sei=保科 kn-aut-mei=英子 aut-affil-num=1 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=2 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=看護学生 (nursing students) kn-keyword=看護学生 (nursing students) en-keyword=食品摂取量 (food intake) kn-keyword=食品摂取量 (food intake) en-keyword=栄養摂取量 (nutrients intake) kn-keyword=栄養摂取量 (nutrients intake) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=43 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Views concerning nursing and nursing course of senior high school guidance teachers kn-title=進路指導を行う高校教師の看護職についての認識 en-subtitle= kn-subtitle= en-abstract=A previous study in Okayama prefecture in 1993 indicated the importance of high school teachers' influential rule on student's choice of nursing course. The same questionnaire survey was sent out by mail in 1996 to guidance teachers of 127 general high schools randomly selected from 617 schools in 10 prefectures, in and around Okayama. Data obtained from 64 teachers were analyzed and the results were as follows; 1. They suggested that shortage of nursing manpower was due to the harsh working conditions such as long and irregular hours (85.9%) and hard work (53.1 %), and also the low social esteem of nurse (32.8%). 2. The aspect of nursing noted by teachers were job specialty (73.4%) and devotion to people (53.l%). There were no statistical difference between these results and those of the previous study. 3. The teachers answered that the new four-year nuersing course (baccalaureate) currently being promoted from over the the present three-year course (associate degree) would be an incentive to students (79.8%) and might increase the number of students choosing to study nursing (57.8%). And they also noted that they would more readily recommend this course to students than before. These rates were significantly increased compared to the results of the previous report. kn-abstract=1993年に岡山県で行った先の研究で,高校生の看護課程の選択にあたって,進路指導を行っている教師の役割が大きい事を報告した｡今回は3年経った1996年に,同じ郵送調査を岡山県および周辺10県の普通科高校617校より無作為に選んだ127校において実施した｡64校より得られた回答を要約すると以下の通りであった｡1.教師が挙げた看護婦不足の理由はまず｢勤務時間が厳しい(85.9%)｣,｢仕事の内容が厳しい(53.1%)｣といった仕事のきつさで,次いで｢仕事の割には社会的評価が低い(32.8%)｣であった｡2.教師が学生に肯定的イメージとして看護課程を勧める理由は,｢まず専門職であること(73.4%)｣,次いで｢人に貢献できる喜び(53.1%)｣であった｡これらの結果は前回の結果と比較して統計的な有意差は認めなかった｡3.近年進められている3年制看護課程(準学士課程)から4年制課程(学士課程)への移行に関して,教師はこれらは学生の関心を呼ぶとし(79.8%),看護課程へ進学する者は増加するであろうとしている(57.8%)｡またこれまでよりこの課程への進学を教師は勧め易くなるとしている(56.3%)。これらの率は前回の結果と比較すると統計的に有意に高かった。 en-copyright= kn-copyright= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=1 ORCID= en-aut-name=ShimoishiYasuaki en-aut-sei=Shimoishi en-aut-mei=Yasuaki kn-aut-name=下石靖昭 kn-aut-sei=下石 kn-aut-mei=靖昭 aut-affil-num=2 ORCID= en-aut-name=KageyamaJingo en-aut-sei=Kageyama en-aut-mei=Jingo kn-aut-name=景山甚郷 kn-aut-sei=景山 kn-aut-mei=甚郷 aut-affil-num=3 ORCID= en-aut-name=ShibuyaKoichi en-aut-sei=Shibuya en-aut-mei=Koichi kn-aut-name=渋谷光一 kn-aut-sei=渋谷 kn-aut-mei=光一 aut-affil-num=4 ORCID= en-aut-name=TohgeHiroko en-aut-sei=Tohge en-aut-mei=Hiroko kn-aut-name=唐下博子 kn-aut-sei=唐下 kn-aut-mei=博子 aut-affil-num=5 ORCID= en-aut-name=EndoHiroshi en-aut-sei=Endo en-aut-mei=Hiroshi kn-aut-name=遠藤浩 kn-aut-sei=遠藤 kn-aut-mei=浩 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部 en-keyword=看護課程 (nursing course) kn-keyword=看護課程 (nursing course) en-keyword=看護 (nursing) kn-keyword=看護 (nursing) en-keyword=看護婦 kn-keyword=看護婦 en-keyword=高校教師 (high school teacher) kn-keyword=高校教師 (high school teacher) en-keyword=進路指導 kn-keyword=進路指導 en-keyword=high school student kn-keyword=high school student END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=33 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The relation of Ikigai (the meaning of one's life) to one's behavioral pattern and belief, researched through the elderly persons at their discharge from hospital kn-title=老人の退院時における生きがいと生活行動および生活信条との関連 en-subtitle= kn-subtitle= en-abstract=There have been few researches about Ikigai of the elderly at the time of leaving the hospital and about the ways of their home nursing care. The purpose of this study is to clarify the relation of Ikigai to one's behavioral pattern and belief. In three national university hospitals and a general hospital in Chugoku region and Shikoku region, ninety-two patients above the age of 70, ready to discharge, were interviewed and given a questionnaire. The questions were about their body condition, behavioral pattern, and belief, and their Ikigai. More than eighty percent of them seem to lead a life worth living at the time of leaving the hospital. The behavioral pattern scores on the "working as a volunteer" and "growing plants" are on a high level of Ikigai. The belief scores on the "enjoy every day" is also on a high level of Ikigai. In this paper the result of this interview is reported and a better nursing care for them is discussed. kn-abstract=退院を控えた老人が,どの程度生きがいを持って退院していくのか,老人自身のどのような生き方が生きがいに影響しているのかについて知るため,それまでの健康状態や,生活信条,生活行動について,退院許可の出た70歳以上の患者92名を対象として,独自の調査用紙に基づき面接調査を行った｡生きが いとこれまでの健康度,生活信条,生活行動の関連性を,分散分析及びt検定により解析した｡生きがいの平均得点が高かった生活行動は｢ボランティア｣で,続いて｢植物｣であった。生きがいの平均得点が高かった生活信条は｢その日を楽しく生きる｣と回答した人が,回答しなかった人との間に有意差があり,老人の退院時の生きがいの得点が高い傾向を示すことが明らかとなった｡ en-copyright= kn-copyright= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=渡辺久美 kn-aut-sei=渡辺 kn-aut-mei=久美 aut-affil-num=1 ORCID= en-aut-name=NakanishiYoshiko en-aut-sei=Nakanishi en-aut-mei=Yoshiko kn-aut-name=中西代志子 kn-aut-sei=中西 kn-aut-mei=代志子 aut-affil-num=2 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=3 ORCID= en-aut-name=TakataSetuko en-aut-sei=Takata en-aut-mei=Setuko kn-aut-name=高田節子 kn-aut-sei=高田 kn-aut-mei=節子 aut-affil-num=4 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=5 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=6 ORCID= en-aut-name=InoshitaHikari en-aut-sei=Inoshita en-aut-mei=Hikari kn-aut-name=猪下光 kn-aut-sei=猪下 kn-aut-mei=光 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=広島県立保健福祉短期大学 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=7 en-affil= kn-affil=香川医科大学医学部看護学科 en-keyword=老人 (the elderly) kn-keyword=老人 (the elderly) en-keyword=生きがい (Ikigai) kn-keyword=生きがい (Ikigai) en-keyword=生活信条 (belief) kn-keyword=生活信条 (belief) en-keyword=生活行動 (behavioral pattern) kn-keyword=生活行動 (behavioral pattern) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=2 article-no= start-page=147 end-page=155 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of adult nursing practices using self-assessment form - analysis in 3rd and 5th weeks of practice - kn-title=学生の自己評価による成人看護実習の達成度 ―3週後･5週後の自己評価結果の分析― en-subtitle= kn-subtitle= en-abstract=The purpose of this study was to evaluate the adult nursing practices using a self-assessment form. Seventy-four third-grade nursing students assessed 11 items in the 3rd and 5th weeks of practice. The scores of all assessment items in the 5th week were significantly higher than these in the 3rd week. The lowest scoreing item at both 3rd and 5th weeks was understanding of the utility of social resources. The students assigned patients with malignant diseases reported higher scores on 3 assessment items. These findings suggest that students should share their experiences and learn about social resources during clinical practice. kn-abstract=この研究目的は,実習目標の達成度に対する学生の自己評価を明らかにすることである｡調査対象は短大の看護学科3年生74名である｡調査は自記式の調査票により成人看護実習の3週後と終了時の5週後に行った｡この自己評価は実習目標11項目について5件法で行った｡その結果,患者理解,患者指導,自己の内面の気づきなど目標は,3週後より5週間の実習によってより評価が高くなった｡最も自己評価が低いのは社会資源の活用の理解であった｡悪性の患者を受け持った学生の方は良性の患者の受け持ち学生より,人間としての態度や死生観などに関して5週後有意に高値であった｡今後の課題は,限られた実習期間内で,学生個々の経験をどのように共有させるかや患者の福祉について理解を深めることである｡ en-copyright= kn-copyright= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=1 ORCID= en-aut-name=IkedaToshiko en-aut-sei=Ikeda en-aut-mei=Toshiko kn-aut-name=池田敏子 kn-aut-sei=池田 kn-aut-mei=敏子 aut-affil-num=2 ORCID= en-aut-name=OhiNobuko en-aut-sei=Ohi en-aut-mei=Nobuko kn-aut-name=大井伸子 kn-aut-sei=大井 kn-aut-mei=伸子 aut-affil-num=3 ORCID= en-aut-name=KageyamaJingo en-aut-sei=Kageyama en-aut-mei=Jingo kn-aut-name=景山甚郷 kn-aut-sei=景山 kn-aut-mei=甚郷 aut-affil-num=4 ORCID= en-aut-name=KanaoNaomi en-aut-sei=Kanao en-aut-mei=Naomi kn-aut-name=金尾直美 kn-aut-sei=金尾 kn-aut-mei=直美 aut-affil-num=5 ORCID= en-aut-name=KobayashiYu en-aut-sei=Kobayashi en-aut-mei=Yu kn-aut-name=小林有 kn-aut-sei=小林 kn-aut-mei=有 aut-affil-num=6 ORCID= en-aut-name=HayashiYuko en-aut-sei=Hayashi en-aut-mei=Yuko kn-aut-name=林優子 kn-aut-sei=林 kn-aut-mei=優子 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=7 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=実習目標 (goal in practice) kn-keyword=実習目標 (goal in practice) en-keyword=自己評価 (self-assessment) kn-keyword=自己評価 (self-assessment) en-keyword=成人看護実習 (adult nursing practice) kn-keyword=成人看護実習 (adult nursing practice) en-keyword=看護学生 (nursing student) kn-keyword=看護学生 (nursing student) en-keyword=実習期間 (period of practice) kn-keyword=実習期間 (period of practice) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=2 article-no= start-page=131 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction of thickened food for patient with dysphagia after surgical treatment for tumor in oral cavity kn-title=口腔腫瘍術後患者の摂食障害に対するとろみ食の導入 en-subtitle= kn-subtitle= en-abstract=Following an operation to remove a tumor in the oral cavity, a patient with dysphagia who had received IVH and intubation feeding for 21 days, was given food thickened with proceeded starch and dextrin (Tromelin). The patient acceptance was good and he could chew and swallow safely and easily than if given ordinary food. The psychological and emotional effects of such postoperational care are also discussed. kn-abstract=口腔腫瘍術後患者は,程度に差はあるが,嚥下･摂食障害をきたしやすい｡その経口摂取開始初期の栄養について,患者が満足して,より快適に摂取でき,経口のみで栄養が満たされるような食事を工夫した｡そのためには,食べやすさを増すためにトロメリンでとろみをつけ, また,食べ残しがないように患者の嗜好を取り入れた｡そして,この嗜好を取り入れたとろみ食を, 口腔腫瘍術後患者一例に提供した｡その結果, とろみ食は,食べやすく,全量摂取でき,良好な栄養状態を維持し,口内の移植皮弁へのトラブルもなく有効であるという結果が得られた｡また,患者が意欲や自信を持つという精神面への効果も見られた｡ en-copyright= kn-copyright= en-aut-name=MoriMisayo en-aut-sei=Mori en-aut-mei=Misayo kn-aut-name=森繰代 kn-aut-sei=森 kn-aut-mei=繰代 aut-affil-num=1 ORCID= en-aut-name=EguchiTomomi en-aut-sei=Eguchi en-aut-mei=Tomomi kn-aut-name=江口智美 kn-aut-sei=江口 kn-aut-mei=智美 aut-affil-num=2 ORCID= en-aut-name=ShimizuYoshie en-aut-sei=Shimizu en-aut-mei=Yoshie kn-aut-name=清水美恵 kn-aut-sei=清水 kn-aut-mei=美恵 aut-affil-num=3 ORCID= en-aut-name=ImuraKeiko en-aut-sei=Imura en-aut-mei=Keiko kn-aut-name=井村桂子 kn-aut-sei=井村 kn-aut-mei=桂子 aut-affil-num=4 ORCID= en-aut-name=MorimotoMisao en-aut-sei=Morimoto en-aut-mei=Misao kn-aut-name=森本操 kn-aut-sei=森本 kn-aut-mei=操 aut-affil-num=5 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=6 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院看護部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院看護部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院看護部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院看護部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院看護部 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 affil-num=7 en-affil= kn-affil=岡山大学医療技術短期大学部看護学科 en-keyword=口腔腫瘍 kn-keyword=口腔腫瘍 en-keyword=術後 (postoperative care) kn-keyword=術後 (postoperative care) en-keyword=摂食障害 (dysphagia) kn-keyword=摂食障害 (dysphagia) en-keyword=とろみ食 (thickened food) kn-keyword=とろみ食 (thickened food) en-keyword=栄養 (nutrition) kn-keyword=栄養 (nutrition) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=2 article-no= start-page=59 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of the system of admitting students on the recommendation of their high school principals kn-title=推薦入試制度の検討 en-subtitle= kn-subtitle= en-abstract=At the nursing department of our college, we introduced in 1993 a system of admitting students on the recommendation of their high school principals, by which about 20 % of the full quota are to be admitted. Since then, our department has graduated students for 3 years. To evaluate the usefulness of this system, students admitted by this system were compared with those admitted by general entrance examination in terms of their college record and the during learning. The college record in the students admitted on recommendation was similar to or slightly better than that in the students admitted by general entrance examination. However, these results were obtained only by comparing the college record, and this system has been used only 3 years. To confirm the usefulness of this recommendation-admission system, further studies are necessary. kn-abstract=岡山大学医療技術短期大学部看護学科では,平成5年度より定員の約20%を募集人員とした推薦入試制度を導入し,以来本年で3回卒業生を送りだしてきた｡本学は来年度から保健学科として新入生を募集することになっており,推薦入学もとられる予定である｡そこで,これを機会に推薦入学学生と一般入試による入学生との在学成績,学習態度等を比較検討し,推薦入試制度の有用性を検討した｡推薦入学生の在学成績は一般入試による入学者の成績とほとんど差はないか,むしろよい傾向にある結果を得た｡今回の検討結果は在学成績のみでしかも期間が3回しか卒業生を送りだしていない時点であることから推薦入学制度の有用性を結論づけるためには更に今後検討が必要である｡ en-copyright= kn-copyright= en-aut-name=KageyamaJingo en-aut-sei=Kageyama en-aut-mei=Jingo kn-aut-name=景山甚郷 kn-aut-sei=景山 kn-aut-mei=甚郷 aut-affil-num=1 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=2 ORCID= en-aut-name=YamadaIchiro en-aut-sei=Yamada en-aut-mei=Ichiro kn-aut-name=山田一朗 kn-aut-sei=山田 kn-aut-mei=一朗 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=3 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 en-keyword=推薦入試 (recommendation-admission system) kn-keyword=推薦入試 (recommendation-admission system) en-keyword=成績 (record) kn-keyword=成績 (record) en-keyword=有用性 (usefulness) kn-keyword=有用性 (usefulness) END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=1 article-no= start-page=45 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Support team and its effects on house remodeling for aged and handicapped persons kn-title=高齢者･障害者のための住宅改造と支援チームの効果 en-subtitle= kn-subtitle= en-abstract=The maintenance and improvement of housing environments are essential for aged and handicapped persons living in a local communities. The support team consists of public health nurses, home helpers, occupational therapists and architects took part in giving an advices for house remodeling in Tsuyama City. We compared the effectiveness of the participation of the team before and after remodeling of housing environment. An interview was conducted at each cases for places of remodeling, living spaces, quantity of care and ease of going. The results are as follows ; 1. The remodeling of bathrooms, participating support team improved the living spaces to be able to take bath. 2. The remodeling of entrances and corridors for leaving beds, improved the living space and the QOL of care recipients. The results suggest that the remodeling of houses dose not always lighten care burdens for caring, but changes the quality of care for aged and handicapped persons. kn-abstract=地域で生活する高齢者･障害者にとって,住宅環境の整備は必須の要件である｡津山市では在宅生活を支援する立場にある保健婦やホームヘルパー,作業療法士等保健･福祉関係者と,建築関係者が共同で支援チームをつくり住宅改造に関わってきた｡本研究では,この支援チームが関わった事例と直接関わらないで当事者と業者のみで改造を実施した事例を比較し,支援チームが関わることの効果をみた｡調査方法は,各事例の家庭を訪問して面接聞き取り調査を行った｡調査内容は調査票を用いて改造箇所,生活空間,介護量,外出の状況について尋ねた｡改造前後の変化を比較して,支援チームの効果について以下のことが明らかになった｡ 1.支援チームの関与による浴室の改造は,入浴が可能となり生活空間が広がるなど改善が認められた｡ 2.離床を目的にした玄関･廊下･居室の改造は,外出などの日常生活行動を広げ,本人のQOLを高めることに役立つ｡以上より住宅の改造が,介護者の介護負担を必ずしも直接軽減するとは限らないが,高齢者･障害者の介護の質に変化を与えることが示唆された。 en-copyright= kn-copyright= en-aut-name=MotohoshioYasuko en-aut-sei=Motohoshio en-aut-mei=Yasuko kn-aut-name=本干尾八州子 kn-aut-sei=本干尾 kn-aut-mei=八州子 aut-affil-num=1 ORCID= en-aut-name=TanakaMisako en-aut-sei=Tanaka en-aut-mei=Misako kn-aut-name=田中操子 kn-aut-sei=田中 kn-aut-mei=操子 aut-affil-num=2 ORCID= en-aut-name=SugiiMasumi en-aut-sei=Sugii en-aut-mei=Masumi kn-aut-name=杉井真澄 kn-aut-sei=杉井 kn-aut-mei=真澄 aut-affil-num=3 ORCID= en-aut-name=HukushimaToshiko en-aut-sei=Hukushima en-aut-mei=Toshiko kn-aut-name=福島敏子 kn-aut-sei=福島 kn-aut-mei=敏子 aut-affil-num=4 ORCID= en-aut-name=TaguchiMichiko en-aut-sei=Taguchi en-aut-mei=Michiko kn-aut-name=田口道子 kn-aut-sei=田口 kn-aut-mei=道子 aut-affil-num=5 ORCID= en-aut-name=TakamiKyoko en-aut-sei=Takami en-aut-mei=Kyoko kn-aut-name=高見京子 kn-aut-sei=高見 kn-aut-mei=京子 aut-affil-num=6 ORCID= en-aut-name=NakashimaYasuko en-aut-sei=Nakashima en-aut-mei=Yasuko kn-aut-name=中島康子 kn-aut-sei=中島 kn-aut-mei=康子 aut-affil-num=7 ORCID= en-aut-name=TsushimaYuko en-aut-sei=Tsushima en-aut-mei=Yuko kn-aut-name=津島裕子 kn-aut-sei=津島 kn-aut-mei=裕子 aut-affil-num=8 ORCID= en-aut-name=YasumotoKatsuhiro en-aut-sei=Yasumoto en-aut-mei=Katsuhiro kn-aut-name=安本勝博 kn-aut-sei=安本 kn-aut-mei=勝博 aut-affil-num=9 ORCID= en-aut-name=TaniguchiNozomi en-aut-sei=Taniguchi en-aut-mei=Nozomi kn-aut-name=谷口望 kn-aut-sei=谷口 kn-aut-mei=望 aut-affil-num=10 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=11 ORCID= en-aut-name=OkanoHatsue en-aut-sei=Okano en-aut-mei=Hatsue kn-aut-name=岡野初枝 kn-aut-sei=岡野 kn-aut-mei=初枝 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=津山市役所 affil-num=2 en-affil= kn-affil=津山市役所 affil-num=3 en-affil= kn-affil=津山市役所 affil-num=4 en-affil= kn-affil=津山市役所 affil-num=5 en-affil= kn-affil=津山市役所 affil-num=6 en-affil= kn-affil=津山市役所 affil-num=7 en-affil= kn-affil=津山市役所 affil-num=8 en-affil= kn-affil=津山市役所 affil-num=9 en-affil= kn-affil=津山市役所 affil-num=10 en-affil= kn-affil=津山市役所 affil-num=11 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=12 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 en-keyword=高齢者・障害者 (aged and handicapped person) kn-keyword=高齢者・障害者 (aged and handicapped person) en-keyword=住宅改造 (house remodeling) kn-keyword=住宅改造 (house remodeling) en-keyword=支援チーム (support team) kn-keyword=支援チーム (support team) END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=2 article-no= start-page=123 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Investigation of collaboration among community-based medical facilities and patient support system in centralcommunity hospitals in Okayama kn-title=岡山県下の地域中核病院における地域医療連携業務,患者支援システムの実態調査 en-subtitle= kn-subtitle= en-abstract=The purpose of this study was to investigate the current status of collaboration among community-based medical facilities and patient support system in ten central community hospitals in Okayama. Interviews were conducted using a questionnaire regarding the current status of collaboration among community-based medical facilities and patient support system in ten central community hospitals. It was revealed that although the size and position of the sections varied, all hospitals were trying to facilitate collaboration among other community-based medical facilities by developing stronger relationships with family doctors. They mainly focused on improving the quality of services for referred patients and referring physicians. Besides, all hospitals possessed another section providing patient support services such as patient education and counseling. Staffs in the sections were trying to build stronger relationship with other health-related and medical facilities in their communities. Finally, it is discussed regarding how to facilitate collaboration among community-based medical facilities and provide patient support system in a university hospital. kn-abstract=本研究の目的は, 1)県下中核病院の地域医療連携,患者支援活動の現状について面接調査を行い,その実態を明らかにすること, 2)その結果をもとに,今後の特定機能病院に求められる地域医療連携や患者支援のあり方を検討する上での参考にすること,の2点にあった｡県下10か所の地域中核病院を対象に,地域医療連携業務やその他の患者支援活動に関する質問紙を作成し,面接調査を行った｡その結果,医療連携部門の歴史や業務内容は様々であったが,どの病院も地域医療連携部門を設置することで,開業医との連携を強化し,紹介･逆紹介の円滑化を図ろうとしている状況がうかがえた｡特に連携業務の中 でも,開業医からの紹介患者を病院にスムーズに受け入れる機能を重視している傾向が見られた｡また,すべての対象病院が地域医療連携以外の患者支援活動を行う部門を有しており,医療相談や地域の医療保健施設との連携強化等の業務を主に行っていた｡これらの調査結果をもとに,特定機能病院である大学病院に求められる地域医療連携･患者支援のあり方について考察した｡ en-copyright= kn-copyright= en-aut-name=NagamuneNoriyo en-aut-sei=Nagamune en-aut-mei=Noriyo kn-aut-name=長宗典代 kn-aut-sei=長宗 kn-aut-mei=典代 aut-affil-num=1 ORCID= en-aut-name=NakanishiYoshiko en-aut-sei=Nakanishi en-aut-mei=Yoshiko kn-aut-name=中西代志子 kn-aut-sei=中西 kn-aut-mei=代志子 aut-affil-num=2 ORCID= en-aut-name=KawataChieko en-aut-sei=Kawata en-aut-mei=Chieko kn-aut-name=川田智恵子 kn-aut-sei=川田 kn-aut-mei=智恵子 aut-affil-num=3 ORCID= en-aut-name=OhtaNiwa en-aut-sei=Ohta en-aut-mei=Niwa kn-aut-name=太田にわ kn-aut-sei=太田 kn-aut-mei=にわ aut-affil-num=4 ORCID= en-aut-name=HayashiYuko en-aut-sei=Hayashi en-aut-mei=Yuko kn-aut-name=林優子 kn-aut-sei=林 kn-aut-mei=優子 aut-affil-num=5 ORCID= en-aut-name=YasukataFumiko en-aut-sei=Yasukata en-aut-mei=Fumiko kn-aut-name=安酸史子 kn-aut-sei=安酸 kn-aut-mei=史子 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=3 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=4 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=5 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=6 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 en-keyword=地域医療連携 (collaboration among community-based medical facilities) kn-keyword=地域医療連携 (collaboration among community-based medical facilities) en-keyword=患者支援システム (patient support system) kn-keyword=患者支援システム (patient support system) END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=1 article-no= start-page=17 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20021225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nursing Care Workers' Concerns about Child Restraint System kn-title=チャイルドシートに関する看護職の意識調査 en-subtitle= kn-subtitle= en-abstract=This study surveyed nursing care workers (workers) understandings of regulations regarding the emergent transportation of childhood patients and child restraint systems (CRS). It also ascertained how they addressed issues involved in the transportation of children by car. Subjects were 725 workers at hospitals or health centers in Okayama City, who were sent an anonymous style questionnaire that was then retrieved by mail (recovery rate 72.2%). As the results, 84.6% of workers had never discussed childhood patient transportation during admission/discharge, with most not being involved in the transportation of children. Only 40.9% answered correctly to 5 questions regarding the exclusive provisions of CRS used to ascertain understanding of the regulations. There were two responses regarding "CRS application to fat children or those with mental restlessness": some encouraged the parents to make a decision and others took advices from doctors. A driver was held responsible for a car accident in Japan when a healthy child was transported without CRS. No case regarding the exclusive provisions has yet been reported. In cases of car accidents, drivers will from now surely be held responsible for the use of CRS. This survey provided nursing care workers for the opportunity to recognize the importance of CRS in the emergenty transportation of children. kn-abstract=本調査は患児の救急搬送時のことやCRS (child restraint system)における法規制の理解などに対する看護職の意識と子どもの車での搬送に関する問題への対応を知る目的で実施した｡岡山市内にある病院および保健所･保健センターに勤務している看護職725名(回収率72.2%)を対象に無記名アンケート方式で郵送法にて実施した｡その結果,入退院時の搬送については｢一度も話したことがない者｣は84.6%で,搬送に関してはほとんど関与していなかった｡CRSの除外規定に関する法的理解について5項目質問したが､正解者は40.9%であった｡その他"肥満児および精神的な不穏時のCRSの対応"として は保護者への判断を促す者と医師の判断を仰ぐ者との2通りの意見があった｡ わが国では健常児の非CRS使用時の搬送時に事故がおき運転者責任を問われたが,除外規定に関する判例ではなかった｡今後は交通事故の発生の場合には確実にCRSの問題は運転者の判断を問われることになる｡看護職としては子どもの搬送にCRSは関与していることを認識することへの示唆となるだろう｡ en-copyright= kn-copyright= en-aut-name=OnoKiyomi en-aut-sei=Ono en-aut-mei=Kiyomi kn-aut-name=小野清美 kn-aut-sei=小野 kn-aut-mei=清美 aut-affil-num=1 ORCID= en-aut-name=SumiyoshiKazuko en-aut-sei=Sumiyoshi en-aut-mei=Kazuko kn-aut-name=住吉和子 kn-aut-sei=住吉 kn-aut-mei=和子 aut-affil-num=2 ORCID= en-aut-name=OkazakiYuka en-aut-sei=Okazaki en-aut-mei=Yuka kn-aut-name=岡崎愉加 kn-aut-sei=岡崎 kn-aut-mei=愉加 aut-affil-num=3 ORCID= en-aut-name=OhtaTakeo en-aut-sei=Ohta en-aut-mei=Takeo kn-aut-name=太田武夫 kn-aut-sei=太田 kn-aut-mei=武夫 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=3 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=4 en-affil= kn-affil=岡山大学医学部保健学科 en-keyword=チャイルドシート (child restraint system) kn-keyword=チャイルドシート (child restraint system) en-keyword=看護職 (nursing care worker) kn-keyword=看護職 (nursing care worker) en-keyword=子どもの搬送 (child transportation) kn-keyword=子どもの搬送 (child transportation) END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=4 article-no= start-page=159 end-page=170 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=カール・レンナー『民族：神話と現実』について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=1.suppl article-no= start-page=61 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=19660130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=日本脳炎ウイルスの電子顕微鏡的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The ultrastructure and developmental process of Japanese B encephalitis virus were studied by electron microscopy in porcine kidney stable (PS) cells infected with the Mukai strain of Japanese B encephalitis virus. The virus and PS cells were kindly supplied by Dr. Y. Kanda Inoue at the Virus Institue of Kyoto University. PS cells were cultivated in bottles containing 10% calf serum and 0.5% lactalbumin hydrolyzate in Earle's balanced solution. Titration of cellassociated virus was estimated by cytopathic effect. At various intervals following infection, the cells were fixed in buffered 1% osmium tetroxide solution, embedded in methacrylates and cut on a Leitz ultramicrotome. After sections were stained in saturated uranyl acetate solution, they were observed in the Hitachi type HU ll electron microscope. Japanese B encephalitis virus particles were hexagonal in thin sections and approximately 40 mμ in the longest diameter, composed of the outer membrane, 30Å in thickness, viroplasm, 30Å in thickness and an electron-dense nucleoid, 25 mμ in diameter, After the virus particles developed in the process of budding on the wall of the cytoplasmic vacuole, they were densely packed in the vacuole usually in random arrangement and occasionally in crystalline arrays. The vacuole containing the virus particles gradually migrated to the cell surface and liberted the particles to the exterior of the cell through a narrow canaliculus which was formed between the vacuole and cell surface. en-copyright= kn-copyright= en-aut-name=HirakiKiyoshi en-aut-sei=Hiraki en-aut-mei=Kiyoshi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=2 ORCID= en-aut-name=SuzukiShinya en-aut-sei=Suzuki en-aut-mei=Shinya kn-aut-name=鈴木信也 kn-aut-sei=鈴木 kn-aut-mei=信也 aut-affil-num=3 ORCID= en-aut-name=TakahashiKenji en-aut-sei=Takahashi en-aut-mei=Kenji kn-aut-name=高橋建次 kn-aut-sei=高橋 kn-aut-mei=建次 aut-affil-num=4 ORCID= en-aut-name=MugurumaMasahito en-aut-sei=Muguruma en-aut-mei=Masahito kn-aut-name=六車昌士 kn-aut-sei=六車 kn-aut-mei=昌士 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=11-12 article-no= start-page=1297 end-page=1305 dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=19661230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Therapeutic Use of a-Mercaptopropionylglycine (Thiola) as a Chelating Agent for Excess Tissue Iron in the Liver kn-title=ヘモジデロージスに対するα-Mercaptopropionylglycine (Thiola)の治療経験-各種キレート剤との比較- en-subtitle= kn-subtitle= en-abstract= kn-abstract=A comparative study of α-mercaptopropionylglycine (α-M P G) as a therapeutic chelating agent for excess tissue iron in the liver with commercially available drugs was undertaken. The drugs used for the compari on were B A L, penicillamine, sodium dithiocarbamate and desferrioxamine B. The materials studied were 11 cases of moderate to severe hepatic hemosiderosis, either primary or secondary, diagnosed with needle liver biopsy specimens. The results were as follows: 1) The decrease of serum iron, disappearance or reduction of stainable tissue iron in the liver, depigmentation of the skin were induced by parenteral or oral administration of α-M P G at the daily dosis of 200 to 450 mg for 2 to 6 months. The phenomena were explained as the results of a chelating effect of α-M P G on excess tissue iron in the liver. 2) No significant effect on essential serum electrolyte such as potassium, calcium was observed during the α-M P G administration. 3) No undesirable side effect was noted, therefore, a prolonged administration was practicable. 4) Iron excretion into the urine was less intense than that with dithiocarbamate, however, it was more intense than that with penicillamine. On the other hand, iron excretion into the feces was observed in the decreasing order with dithiocarbamate, desferrioxamine B, penicillamime, and α-M P G. The daily excretion of iron into urine amounted 2 to 4 mg with α-M P G. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=1 ORCID= en-aut-name=FukushimaIsao en-aut-sei=Fukushima en-aut-mei=Isao kn-aut-name=福島功 kn-aut-sei=福島 kn-aut-mei=功 aut-affil-num=2 ORCID= en-aut-name=OrimeAkio en-aut-sei=Orime en-aut-mei=Akio kn-aut-name=折免昭雄 kn-aut-sei=折免 kn-aut-mei=昭雄 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部小坂内科 affil-num=2 en-affil= kn-affil=岡山大学医学部小坂内科 affil-num=3 en-affil= kn-affil=岡山大学医学部小坂内科 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=581 end-page=590 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Response of luteinizing hormone and follicle stimulating hormone to luteinizing hormone-releasing hormone in prepubertal and pubertal chidren, as measured by a highly sensitive immunradiometric assay kn-title=LHRH 負荷試験による小児期のゴナドトロピン分泌予備能に関する検討ー高精度 LH, FSH 測定法 (IRMA 法) による分泌動態の解析ー en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the age-related changes in the pituitary responsiveness to luteinizing hormone-releasing hormone (LH-RH), the consentrations of serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured before and after LH-RH administra-tion using the highly sensitive immunoradiometric assay (IRMA) in 283 normal children (161 males and 77 females) between 4 and 14 years old and in 22 patients (18 males and 4 females) with pituitary dwarfism. Then, the area of response above the basal level [integrated response(Σ)] of LH and FSH during 60 minutes after LH-RH injection was calculated to evaluate the pituitary response to LH-RH. The integrated LH responses progressively increased in the boys from 8 years of age and in the girls from 6 years of age, and they continued to increase up to 14 years of age. The integrated FSH response showed a significant decrease in all grups in the girls, but did not show any change in the boys. In patients with pituitary dwarfism who were subsequently found to be gonadotropin deficient, the level of Σ LH60 was low (below-2SD) It is concluded that integrated responses of gonadotropins, especially LH, to LH-RH are useful to evaluate the maturation of the hypothalamic-pituitary-gonadal axis, and that incre-ment of LH responsiveness to LH-RH already begins before the onset of puberty. The peak appearance time of gonadotropins after LH-RH is also important in the assessment of the maturation of the hypothalamic-pituitary-gonadal axis because FSH reached its peak carlier in the pubertal group than in the prepubertal group. en-copyright= kn-copyright= en-aut-name=HiguchiJoji en-aut-sei=Higuchi en-aut-mei=Joji kn-aut-name=樋口譲二 kn-aut-sei=樋口 kn-aut-mei=譲二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部小児科学教室 en-keyword=LHRH kn-keyword=LHRH en-keyword=LH kn-keyword=LH en-keyword=FSH kn-keyword=FSH en-keyword=下垂体性小人症 kn-keyword=下垂体性小人症 en-keyword=ゴナドトロピン分泌不全 kn-keyword=ゴナドトロピン分泌不全 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=399 end-page=412 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studis on the pathogenesis of idiopathic interstitial pneumonia Part 1. Clinical features including various laboratory and roentogenologic findings in regard to the response to the treatment kn-title=特発性間質性肺炎の病態に関する研究　第1編　臨床集計による特発性間質性肺炎の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical features, laboratory findings including hematological and biochemical exmination, pulmanary function test and chest x-ray findings of patients with idiopathic interstital pneumonia (IIP) were analyzed to determine the response to steroid therapy. Sixty three patients with IIP were analyzed in comparison with 43 patietns of interstitial pneumonia due to various diseases such as collagen disease, tuberculosis and chronic obstructive lung disease. Almost half of the patients with IIP were treated with steroids and improvement of interstitial pneumonia was shown only in the patients given steroid therapy. The improvement with steroid therapy was shown to the 50% in acute form of IIP, 32.1% in chronic form of IIP and 36.8% in total. Furthermore, the response of steroid therapy was better in patients with a relatively high oxygen level and high vital capacity and with no honeycombing on the chest X-ray film. These findings indicate the therapeutic effectivesess of steroid therapy in some patients and it should be started in the early stage of the clinical of IIP to obtain a good response rate. en-copyright= kn-copyright= en-aut-name=FujitaMichio en-aut-sei=Fujita en-aut-mei=Michio kn-aut-name=藤田道雄 kn-aut-sei=藤田 kn-aut-mei=道雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=idiopathic interstitial pneumonia kn-keyword=idiopathic interstitial pneumonia en-keyword=Steroid therapy kn-keyword=Steroid therapy en-keyword=Prognosis of IIP kn-keyword=Prognosis of IIP en-keyword=Chest x-ray finding kn-keyword=Chest x-ray finding END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=1 article-no= start-page=39 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Vocal Expression in Reciting Poems : An Analytical Study focused on Lines, Intervals between Lines and Passages kn-title=詩の朗読における音声表現―行と行間、連間に焦点をあてた分析的研究― en-subtitle= kn-subtitle= en-abstract= kn-abstract=詩の朗読では「間」が重要だと言われている。しかし、「間」がどのようにとられているかについては不明である。本稿では、朗読における「間」の実態を明らかにするために、金子みすゞの「私と小鳥と鈴と」の朗読の音声分析と、「間」が聞き手に及ぼす感受の影響に関する認知実験を行った。得られた成果は以下の通り。 ・大人の専門家の朗読では、行の所要時間や行間の「間」が異なり、表現にメリハリが感じられる。 ・こどもの朗読は全体に速く、行と行間との差が大人に比べて少ない。しかし、全体的な時間変化は大人の専門家と類似したパターンをとっている。 ・聞き手は「間」の微妙な変化を感じ取っている。たとえ短くても詩の内容に応じて変化する「間」を好む者が多い。機械的な「間」では詩を十分に味わうことができない。 en-copyright= kn-copyright= en-aut-name=KawadaMisato en-aut-sei=Kawada en-aut-mei=Misato kn-aut-name=川田美里 kn-aut-sei=川田 kn-aut-mei=美里 aut-affil-num=1 ORCID= en-aut-name=OkuShinobu en-aut-sei=Oku en-aut-mei=Shinobu kn-aut-name=奥忍 kn-aut-sei=奥 kn-aut-mei=忍 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=高松市立太田南小学校 affil-num=2 en-affil= kn-affil=岡山大学教育学部 en-keyword=詩 (poem) kn-keyword=詩 (poem) en-keyword=朗読 (recite) kn-keyword=朗読 (recite) en-keyword=音声表現 (voice expression) kn-keyword=音声表現 (voice expression) en-keyword=金子みすゞの「私と小鳥と鈴と」 ("I, little bird and bell") kn-keyword=金子みすゞの「私と小鳥と鈴と」 ("I, little bird and bell") END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=945 end-page=949 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Four cases of villous adenoma of rectum in our department : Comparative study of 88 cases of villous adenoma in Japan kn-title=直腸絨毛腺腫の4例―本邦報告88例についての検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=We reviewed the charts of 4 patients with villous adenoma of the rectum seen at the First Dept. of Surg., Okayama Univ. Med. School between 1971 and 1990. This study included 2 men and 2 women, ranging in age from 52 to 83 years. Polypectomy was performed on 3 patients with villous adenoma and low anterior resection was performed on 1 patient. Recurrent tumors developed in one of the 3 patients who had undergone polypectomy. In addition, a series of 88 patients with villous adenoma of the rectum reported in Japan were also reviewed. The average age of the patients with villous adenoma was 62.9. There were 47 men and 41 women. The presenting symptoms of the 69 patients with tumor were mainly bleeding and watery or mucinous diarrhea. The tumor size and invasiveness of malignancy were also examined. The likelihood of malignancy correlated with size of tumor, and none of the lesions smaller than 2cm contained a malignant tumor site. Surgeons should consider the size, location and malignant change of the villous tumor with as much precise examination before and during operation so that unnecessary over surgery is avoided. en-copyright= kn-copyright= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=3 ORCID= en-aut-name=OokuraToshihiro en-aut-sei=Ookura en-aut-mei=Toshihiro kn-aut-name=大倉充博 kn-aut-sei=大倉 kn-aut-mei=充博 aut-affil-num=4 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=5 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=6 ORCID= en-aut-name=SuzakiKiichi en-aut-sei=Suzaki en-aut-mei=Kiichi kn-aut-name=須崎紀一 kn-aut-sei=須崎 kn-aut-mei=紀一 aut-affil-num=7 ORCID= en-aut-name=YamashitaHiroshi en-aut-sei=Yamashita en-aut-mei=Hiroshi kn-aut-name=山下博士 kn-aut-sei=山下 kn-aut-mei=博士 aut-affil-num=8 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=9 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=10 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=直腸 kn-keyword=直腸 en-keyword=絨毛腺腫 kn-keyword=絨毛腺腫 en-keyword=癌化 kn-keyword=癌化 en-keyword=電解質異常 kn-keyword=電解質異常 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=259 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental and clinical studies on interferon and its inducers Part 2. β-carboxyethylgermanium sesquioxide (Ge-132) in the management of acute nonlymphocytic leukemia patients at remission phase kn-title=インターフェロン並びにインターフェロン誘発剤に関する基礎的・臨床的研究　第2編　急性非リンパ性白血病寛解期における β-Carboxyethylgermanium sesquioxide (Ge-132) の臨床効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinieal of Ge-132 in the management of acute nonlymphocytic leukemia (ANLL) patients at remission phase were studied. Twenty-two ANLL patients with complete remission were randomized into Groups A and B. Patients in Group A were treated with the combianation with Ge-132 (2,250mg/day ; p. o daily) and intermittent-alternating chemotherapy 〔daunorubicin, vincristine, cytosine arabinoside and prednisolone (DVCP)/aclarubicin vincristine cytosine arabinoside and prednisolone (AVCP)〕and patients in Groyp B were treated with intermittent-alter nating chemotherapy (DVCP/AVCP) alone. Evaluable patients were 7 in Group A and 10 in Group B. Remission duration and survival time were not significantly different between Groups A and B. (median remission duration ; 5.7 month in Group A vs 8.1 month in Group B/median surival time ; 23.9month in Group A vs 18.3month in Group B) The rates of second remission in relapsed cases were not significantly different between Groups A and B.〔2 of 7,(28.6%) in Group A vs 3 of 10,(30.0%) in B〕Ge-132 did not accelerate the recovery from myelosuppression after intensification with the DVCP regimen. The incidence of liver damage and levels of serum GOT and GPT tended to be lower in Group A than in Group B. In this clinical study the incidence of liver damage tended to be lowere in patients treated with Ge-132. The liver damage which often develops during intensificantion chemotherapy, not only limits the chemotherapy but also causes adverse effects on the quality of life of the patient. In part 1 of this series, Ge-132 was reported to activate the neutrophil chemiluminescence. Ge-132 seems to be useful in the management of ANLL patients not only by the enhancement of the host defense system but also by the prevenation of liver damage. en-copyright= kn-copyright= en-aut-name=FukumotoMitsuhiro en-aut-sei=Fukumoto en-aut-mei=Mitsuhiro kn-aut-name=福本光宏 kn-aut-sei=福本 kn-aut-mei=光宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Ge-132 kn-keyword=Ge-132 en-keyword=Biological response modifier kn-keyword=Biological response modifier en-keyword=Acute nonlymphocytic leukemia kn-keyword=Acute nonlymphocytic leukemia en-keyword=Immunotherapy kn-keyword=Immunotherapy END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=83 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on laser photocoagulation for retinopathy of prematurity kn-title=レーザー光凝固による未熟児網膜症の治療に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Forty eyes in twenty-two cases in the active phase of retinopathy of prematurity were treated with laser photocagulation. Thiry (93.7%) of the 32 eyes in type I and intermediate type were found in the cicartrical phase grade 1. In type Ⅱ in which cryocautery was used as combination therapy, only 2 eyes (25.0%) were found in grade 1, 2 eyes (25.0%) in grade 2, 1 eye (12.5%) in grade 4 and 3 eyes (37.5%) in grade 5. All 21 eyes in which photocoagulation was performed up to the middle of stage 3 were found in grade 1 (100%). However, among 11 eyes in which photocoagulation were performed in late stage 3, 9 eys (81.8%) were found in grade 1, and 2 eyes (18.2%) in grade 2. In conclusion, if adequate laser photocoagulation is performed in avascular ares at the middle of stage 3 of type Ⅰ and intermediate type, treatment in cicartrical phase grade 1 is possible. Laser photocoagulation is clearly more effective than the xenon are photocoagula-tion or cryocautery. However, in type Ⅱ it is difficult to control the condition by photocagulation alone, and early diagnosis followed by combination therapy using cryocautery is reqired. en-copyright= kn-copyright= en-aut-name=OhtakiChiaki en-aut-sei=Ohtaki en-aut-mei=Chiaki kn-aut-name=大滝千秋 kn-aut-sei=大滝 kn-aut-mei=千秋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部眼科学教室 en-keyword=未熟児網膜症 kn-keyword=未熟児網膜症 en-keyword=レーザー光凝固 kn-keyword=レーザー光凝固 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=833 end-page=839 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A report of thirteen cases of familial polyposis coli kn-title=教室における家族性大腸ポリポーシス症例の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Familial polyposis coli (FPC) is an inherited nonsex linked mendelian dominant disease in which there exist at least 100 adenomatous polyps throughout the entire large bowel. Thirteen patients with FPC, of whom 7 were male and 6 female, visited our department between 1966 and 1990. The mean age of the patients was 33.5. Eight of the 13 patients (61.5%) had gastric and/or duodenal polyps, and eight of the 13 patients (61.5%) had colorectal carcinomas at admission. Colectomy with ileorectal anastomosis (IRA) was performed on 2 patients. The functional results were good bowel frequency, good sphincter control and lack of dietary restriction. Clinical experience tended to suggest that the risk of rectal cancer following IRA is extreme and unacceptable, although our two cases were still free of rectal cancer. Since 1980, the total colectomy with mucosal proctectomy and ileal pouch-anal anastomosis was the procedure of choice in our department. Good results were obtained on the six patients on whom this procedure was performed. en-copyright= kn-copyright= en-aut-name=WatanabeKazuhiko en-aut-sei=Watanabe en-aut-mei=Kazuhiko kn-aut-name=渡辺和彦 kn-aut-sei=渡辺 kn-aut-mei=和彦 aut-affil-num=1 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=2 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=3 ORCID= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=4 ORCID= en-aut-name=MatubaraNagahide en-aut-sei=Matubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=5 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=6 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=7 ORCID= en-aut-name=SuzakiKiichi en-aut-sei=Suzaki en-aut-mei=Kiichi kn-aut-name=須崎紀一 kn-aut-sei=須崎 kn-aut-mei=紀一 aut-affil-num=8 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=9 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=10 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=家族性大腸ポリポーシス kn-keyword=家族性大腸ポリポーシス en-keyword=胃・十二指腸ポリープ kn-keyword=胃・十二指腸ポリープ en-keyword=癌化 kn-keyword=癌化 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=51 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinicopathological studies in patients with colorectal cancers without lymphnode metastasis kn-title=リンパ節転移を認めない大腸癌の臨床病理学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The clinicopathologic findines and the prognosis of 154 patients without regional lymph nodes metastasis or distant metastasis (n(-)group) were compared with those in 134 patients with regional lymph nodes metastasis and without distant netastasis (n(+)group). The mean age of the n(-) group was significantly younger than that of the n(+) group (p<0.05) and there was no significant sexual preponderance. The proportion of the cases without lymphatic vessel invasion in the n(-) group was significantly higher than in the n(+) group (p<0.01). The proportion of the cases without venous invasion was significantly higher in the n(-) group than in the n(-) group (p<0.05). There was no difference in cumulative surval rate of patients in then(-) group than in the n(+) group (p<0.05). There was no difference in cumulative survial rate of patients in the n(-) group in respect to the background factors such as sex, tumor site, and venous invasion. However, the survial rate of patients whose cancer invasion was limited within the mucosa (m), submucosa (sm) and musclar propria (pm) was significantly better than that of patients who had subserosal or subadventitial penetration (ss(al)), serosal or adeventitial penetration (s(a2)) and cancer invasion adjacent organs (si(ai))(p<0.05). The survial rate of patients with lymphatic vessel invasion was significantly higher than that of patients without lymphatic vessel invasion (p<0.05). That the poor prognostic factors in n(-) colorectal cancer patients are cancer penetration to/beyond ss(al), or positive lymphatic vessal invasion. en-copyright= kn-copyright= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=3 ORCID= en-aut-name=HamadaHiroshi en-aut-sei=Hamada en-aut-mei=Hiroshi kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=4 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=5 ORCID= en-aut-name=OiritaKunzo en-aut-sei=Oirita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=大腸癌 kn-keyword=大腸癌 en-keyword=リンパ節転移 kn-keyword=リンパ節転移 en-keyword=n(0) kn-keyword=n(0) END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=809 end-page=820 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on IgG subclass antibodies in asthmatics with late asthmatic responses Part 2. Antigen-specific IgG subclass antibodies in the BALF of asthmatics with late asthmatic responses kn-title=遅発型気道反応におけるIgG サブクラス抗体に関する研究　第2編　気管支肺胞洗浄液中抗原特異的 IgG サブクラス抗体と遅発型気道反応の関連について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Immunoglobulin classes which induce a non-immediate asthmatic response (non-IAR) in the case of low level of IgE antibody are still unknown, although IAR is mediated by IgE. To elucidate the relationship between antibodies and late asthmatic responses (LAR), antigen-specific IgG subclass antibodies in the serum and bronchoalveolar lavage fluid (BALF) of asthmatics were measured by avidin-biotin ELISA before provocation by antigen. The BALF levels of IgG and IgG1 antibodies to mite and Candida antigen in bronchial asthmatics were higher than those in healthy subjects (p<0.05). Followed by inhalation of house dust or Candida antigen, bronchial asthmatics were divided into group A (higher levels of BALF IgG1 antibody) and gourp B (lower levels of BALF IgG1 antibody). The percentages of LAR including DAR after inhalation of house dust antigen in group A were significantly higher than those in group B (p<0.05). The percentages of LAR including DAR after inhalation of Candida antigen in group A were significantly higher than those in group B (p<0.01). In asthmatics with LAR after inhalation of house dust antigen or Candida antigen, the BALF levels of antigen-specific IgG and IgG1 antibodies were significantly higher than those in asthmatics without LAR of healthy subjects (p<0.01). In asthmatics with LAR after inhalation of house dust antigen or Candida antigen, the BALF levels of antigen-specific IgG and IgG1 antibodies were significantly higher than those in asthmatics without LAR of healthy subjects (p<0.01). In asthmatics with LAR, the relative (to albumin) of coefficients of excretion (RCE) in the BALF of antigen-specific IgG and IgG1 antibodies were higher than those in asthmatics without LAR of healthy subjects. These findings suggest that local production of antigen-specific IgG and IgG1 antibodies incerases in asthmatics with LAR, and that these antibodies may induce LAR. en-copyright= kn-copyright= en-aut-name=OgurusuKazuro en-aut-sei=Ogurusu en-aut-mei=Kazuro kn-aut-name=小栗栖和郎 kn-aut-sei=小栗栖 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=遅発型気道反応 kn-keyword=遅発型気道反応 en-keyword=IgG サブクラス抗体 kn-keyword=IgG サブクラス抗体 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=抗原吸入誘発試験 kn-keyword=抗原吸入誘発試験 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=655 end-page=661 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Maintenance therapy with erythropoietin for renal anemia kn-title=腎性貧血に対するエリスロポエチンの維持投与法の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The beneficial effect of recombinant human erythropoietin (EPO) for renal anemia in patients with chronic hemodialysis has been esthablishel. EPO is reported to be effective against renal anemia when adeministered at a dose 3,000 units three times a week. However, only a few studies have been made on the therapy to maintain the anemia-improving effect of EPO. In the present study, we performed EPO maintenance therapy on 22 hemodialysis patients with renal anemia. EPO was initialy administered at a dose of 3,000 units three times a week, and maintenance therapy was initiated after 12 weeks of treatment. The patients were divided into two groups, with EPO being administered at a dose of 1,500 units twice a week to one group and three times a week to the other. The duration of maintenance therapy was set at eight weeks. The anemia-improving effect of EPO was found to be satisfactorily maintained in both groups and no significant difference was noted between them. According, it may be better to use the lower dose regimen of 1,500 units twice a week for the maintenance therapy of renal anemia. en-copyright= kn-copyright= en-aut-name=OguraTosio en-aut-sei=Ogura en-aut-mei=Tosio kn-aut-name=小倉俊郎 kn-aut-sei=小倉 kn-aut-mei=俊郎 aut-affil-num=1 ORCID= en-aut-name=NagakeYoshio en-aut-sei=Nagake en-aut-mei=Yoshio kn-aut-name=長宅芳男 kn-aut-sei=長宅 kn-aut-mei=芳男 aut-affil-num=2 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=3 ORCID= en-aut-name=HaramotoToshinori en-aut-sei=Haramoto en-aut-mei=Toshinori kn-aut-name=原本俊則 kn-aut-sei=原本 kn-aut-mei=俊則 aut-affil-num=4 ORCID= en-aut-name=MatsumotoMitsuhito en-aut-sei=Matsumoto en-aut-mei=Mitsuhito kn-aut-name=松本光仁 kn-aut-sei=松本 kn-aut-mei=光仁 aut-affil-num=5 ORCID= en-aut-name=HiramatsuMakoto en-aut-sei=Hiramatsu en-aut-mei=Makoto kn-aut-name=平松信 kn-aut-sei=平松 kn-aut-mei=信 aut-affil-num=6 ORCID= en-aut-name=MinoYasuaki en-aut-sei=Mino en-aut-mei=Yasuaki kn-aut-name=味埜泰明 kn-aut-sei=味埜 kn-aut-mei=泰明 aut-affil-num=7 ORCID= en-aut-name=NishimuraShigeaki en-aut-sei=Nishimura en-aut-mei=Shigeaki kn-aut-name=西村誠明 kn-aut-sei=西村 kn-aut-mei=誠明 aut-affil-num=8 ORCID= en-aut-name=TaniaiKazuhi en-aut-sei=Taniai en-aut-mei=Kazuhi kn-aut-name=谷合一陽 kn-aut-sei=谷合 kn-aut-mei=一陽 aut-affil-num=9 ORCID= en-aut-name=KumagaiIsao en-aut-sei=Kumagai en-aut-mei=Isao kn-aut-name=熊谷功 kn-aut-sei=熊谷 kn-aut-mei=功 aut-affil-num=10 ORCID= en-aut-name=KomotoKiichi en-aut-sei=Komoto en-aut-mei=Kiichi kn-aut-name=河本紀一 kn-aut-sei=河本 kn-aut-mei=紀一 aut-affil-num=11 ORCID= en-aut-name=TakehisaYoshiaki en-aut-sei=Takehisa en-aut-mei=Yoshiaki kn-aut-name=竹久義明 kn-aut-sei=竹久 kn-aut-mei=義明 aut-affil-num=12 ORCID= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=13 ORCID= en-aut-name=SugaYoshihiko en-aut-sei=Suga en-aut-mei=Yoshihiko kn-aut-name=菅嘉彦 kn-aut-sei=菅 kn-aut-mei=嘉彦 aut-affil-num=14 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=5 en-affil= kn-affil=尾道市立市民病院内科 affil-num=6 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=7 en-affil= kn-affil=落合病院内科 affil-num=8 en-affil= kn-affil=岡山中央病院内科 affil-num=9 en-affil= kn-affil=岡山中央病院内科 affil-num=10 en-affil= kn-affil=寺岡記念病院腎センター affil-num=11 en-affil= kn-affil=因島総合病院内科 affil-num=12 en-affil= kn-affil=鳥取市立病院内科 affil-num=13 en-affil= kn-affil=姫路第一病院内科 affil-num=14 en-affil= kn-affil=菅病院内科 affil-num=15 en-affil= kn-affil=岡山大学医学部第三内科学教室 en-keyword=腎性貧血 kn-keyword=腎性貧血 en-keyword=エリスロポエチン kn-keyword=エリスロポエチン en-keyword=維持投与法 kn-keyword=維持投与法 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=797 end-page=807 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on IgG subclass antibodies in asthmatics with late asthmatic responses Part 1. Serum antigen-specific IgG subclass antibodies in asthmatics with late asthmatic response kn-title=遅発型気道反応におけるIgG サブクラス抗体に関する研究　第1編　血清中抗原特異的 IgG サブクラス抗体と遅発型気道反応の関連について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The immediate asthmatic response is mainly induced by IgE-dependent mechanisms. However, the late asthmatic response (LAR) is induced by inhalation of antigens without the participation of antigen-specific IgE antibodies in some asthmatics, especially in intractable asthma induced by Candida antigen. To elucidate the relationship between antibodies and those bronchial responses, the antigen-specific IgG subclass antibodies in sera from asthmatics were measureed and compared with IgE antibody. The avidin-biotin ELISA (enzyme-linked immunosorbent assay) method was established for the measurement of specific IgG and IgG subclass antibodies to mite or Candida antigen. Serum levels of IgG and IgG1 antibodies to mite and Candida antigen in bronchial asthmatics were significantly higher than those in healthy subjects (p<0.01). Bronchial asthmatics who were tested with inhalation of house dust or Candida antigen were divided into group A (higher levels of serum IgG1 antibody) and group B (lower levels of serum IgG1 antibody). The percentage of LAR including DAR after inhalation of house dust antigen in group A were significantly higher than those in group B (p<0.01). The percentages of LAR and LAR including DAR after inhalation of Candida antigen in group A were significantly higherSerum levels of house du than those in group B(p<0.01). Serum levels of antigen-specific IgG and IgG1 antibodies in asthmatics with LAR after inhalation of house dust or Candida antigen were significantly higher than those in asthmatics with IAR or non-responders (p<0.01). The serum level of specific IgE antibody to these antigens in asthmatics with LAR after inhalation of house dust or Candida antigen was slightly lower than that in the asthmatics without LAR, though the difference was not significant. These findings suggest that high serum levels of specific IgG and IgG1 antibodies to adequate antigens play a role in inducing an attack in asthmatics with LAR. en-copyright= kn-copyright= en-aut-name=OgurusuKazuro en-aut-sei=Ogurusu en-aut-mei=Kazuro kn-aut-name=小栗栖和郎 kn-aut-sei=小栗栖 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=遅発型気道反応 kn-keyword=遅発型気道反応 en-keyword=IｇG サブクラス抗体 kn-keyword=IｇG サブクラス抗体 en-keyword=IgE 抗体 kn-keyword=IgE 抗体 en-keyword=抗原吸入誘発試験 kn-keyword=抗原吸入誘発試験 en-keyword=難治性喘息 kn-keyword=難治性喘息 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=741 end-page=747 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lateral lymph node metastasis of rectal carcinoma kn-title=教室における直腸癌側方リンパ節転移の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The records of 182 consecutive rectal carcinomas treated in this department between JAN 1978 and DEC 1990 were reviewed to assess the outcome of the patients presenting with lateral pelvic lymph node infiltration. Lateral lymph node dissection was carried out in 24 (42.1%) of the 57 Ra tumors and 63 (72.4%) of the 87 Rb tumors, but in none of the 38 cases of Rs tumors. Lymph node involvement was detected 0% and 15.9% of the Ra and Rb tumors, respectively. In this series, none of the cases in which the tumors were confined to m, sm and pm had positive lymph nodes. However, 23.3% of the 43 cases in which invasion was beyond pm showed positive lymph node invasion. The main lymph nodes involved were located in the roots of the middle rectal arteries. Half of the patients presented with distant metastases within one year, with poorer prognosis considering the mean survival rate of 1.8 years. In conclusion, we advocate that in Rb rectal tumors with circular invasion or invasion beyond the pm, careful lateral lymph nede dissection should be carried out. On the other hand, we suggest the use of preoperative radiation therapy which could improve the curability, the disease-free interval, and survival rates. en-copyright= kn-copyright= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=3 ORCID= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=4 ORCID= en-aut-name=YasuiYoshimasa en-aut-sei=Yasui en-aut-mei=Yoshimasa kn-aut-name=安井義政 kn-aut-sei=安井 kn-aut-mei=義政 aut-affil-num=5 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=6 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=7 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=8 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=9 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=10 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=直腸癌 kn-keyword=直腸癌 en-keyword=側方郭清 kn-keyword=側方郭清 en-keyword=側方転移 kn-keyword=側方転移 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=587 end-page=598 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Acute leukemia in the aged : Chemotherapeutic effect of aclarubicin on acute nonlymphocytic leukemia kn-title=高齢者白血病の治療に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate clinical management of acute nonlymphocytic leukemia (ANLL) in the aged, the chemotherapeutic effects of aclarubicin (ACR) were studied in 20 ANLL patients (M1 5, M2 3, M4 5, M5b 6, M6 1). All patients were over 70 years old. The ratio of male to female was 16 : 4 and age ranged from 70 to 84 years old (mediam : 76y/o). Nineteen patients were untreated, one case had previous treament and 2 patients showed hypoplastic marrow on admission. ACR was administered by intravenous drip infusion at a dose of 14mg/m2/day for 7-10 days and repeated after recovery of myelosuppression. Eight patients (40%) obtained complete remission (CR) : 1 of 5 M1 (20%), 3 of 5 M4 (60%), 4 of 6 M5b (66.7%) and none of M2 or M6. CR ratio was 44% in 18 typical ANLL patients excluding the two patients with hypoplastic marrow, who did not attain CR. The duration of CR was from 1.3 to 11.3 months (median : 7.3 months) and survial time ranged from 6.6 to 15.6 months (median : 11.8 months) in patients with CR. Although side effects on the digestive system such as nausea, vomiting and anorexia were seen in 11 of 20 patients, these effects were controllable. None of the patients showed cardiac toxicity. ACR is expected to be useful in the clinical management of ANLL in patients over 70 years old, especially for M4 and 5 in the aged. en-copyright= kn-copyright= en-aut-name=NakamuraTohru en-aut-sei=Nakamura en-aut-mei=Tohru kn-aut-name=中村達 kn-aut-sei=中村 kn-aut-mei=達 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=acute leukemia in the aged kn-keyword=acute leukemia in the aged en-keyword=antileukemic chemotherapy kn-keyword=antileukemic chemotherapy en-keyword=aclarubicin kn-keyword=aclarubicin END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=549 end-page=560 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on plasma cyclic nucleotide levels in acute leukemia kn-title=急性白血病における血漿cyclic nucleotides動態に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Plasma levels of cyclic nucleotides were measured in 71 patients with acute leukemia [50 patients with acute nonlymphocytic leukemia (ANLL), five patients with hypoplastic leuke-mia, and 16 patients with acute lymphocytic leukemia (ALL)], five patients with myelodysplas-tic syndrome (MDS), and 47 healthy volunteers. The cyclic GMP (c-GMP) level, cyclic AMP (c-AMP) level, and c-AMP/c-GMP ratio in healthy volunteers were 15.74±5.10 pmol/ml, 3.20±1.15 pmol/ml and 5.39±2.18, respectively. In the patients with untreated acute leukemia other than hypoplastic leukemia, c-GMP levels were significantly elevated (ANLL : 11.31±13.61 pmol/ml ; ALL : 10.66±7.23 pmol/ml) and c-AMP/c-GMP ratios were significantly reduced (ANLL : 2.01±1.03 ; ALl : 1.66±1.03). These values normalized at remission, than increased or decreased again with recurrence of the disease. Although patients with MDS showed normal c-GMP levels or c-AMP/c-GMP rations, these values were increased or decreased when progression to acute leukemia occurred. There was correlation between c-GMP levels and peripheral leukocyte counts (r=0.429,p<0.05), plasma c-GMP levels and peripheral leukemic cell counts (r=0.412,p<0.05), c-AMP/c-GMP rations and peripheral leukocyte counts (r=-0.577,p<0.05), c-AMP/c-GMP rations and periph-eral leukemic cell counts (r=-0.512,p<0.05), and c-AMP/c-GMP rations and periph-eral leukemic cell counts (r=-0.512,p<0.05), and c-AMP/c-GMP rations and maximum counts of colonies derived from leukemic blast progenitors (r=-0.996,p<0.01). Since plasma levls of cyclic nucleotides reflect the leukemic cell proliferation, measurement of these nucleotides was considered useful for monitoring leukemic cell volume. en-copyright= kn-copyright= en-aut-name=NonakaKenichi en-aut-sei=Nonaka en-aut-mei=Kenichi kn-aut-name=野中研一 kn-aut-sei=野中 kn-aut-mei=研一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=血漿 cyclic nucleotides kn-keyword=血漿 cyclic nucleotides en-keyword=急性白血病 kn-keyword=急性白血病 en-keyword=低形成型白血病 kn-keyword=低形成型白血病 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=489 end-page=498 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical trial of enhancement method fro ultrasonographic diagnosis of thyroid nodules kn-title=結節性甲状腺腫の超音波診断における Enhancement 法の試み en-subtitle= kn-subtitle= en-abstract= kn-abstract=Enhancement in thyroid ultrasonography was investigated with thyroid lymphography by injection of Lipiodol into thyroid nodules in 50 patients. On plain thyroid ultrasonography (PU), the echo levels of normal and tumorous portions of the thyroid glands were evaluated. Then, the echo level ratios (P-N/T) were calculated. Moreover, by the same method, the echo level ratios between normal and tumorous portions of the thyroid glands were culculated 6 hours after Lipiodol injection (E-N/T), when the greatest enhancement was anticipated. The mean value of P-N/T was 1.305, and that of E-N/T was 1.474. The echo level ratio was significantly elevated in the enhancement method (p<0.0014). We concluded that the enhancement is obtained with Lipiodol injection into the normal portion of the thyroid glands, regardless of whether the tumor is benign or malignant and with or without cystic degeneration. This method is useful in promoting quality and location diagnosis of thyroid nodules. N : echo level value in the normal portion of thyroid gland T : echo level value in the tumorous portion of thyroid gland N/T : echo level raito en-copyright= kn-copyright= en-aut-name=TakeuchiRyuzo en-aut-sei=Takeuchi en-aut-mei=Ryuzo kn-aut-name=竹内龍三 kn-aut-sei=竹内 kn-aut-mei=龍三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=超音波診断 kn-keyword=超音波診断 en-keyword=結節性甲状腺腫 kn-keyword=結節性甲状腺腫 en-keyword=Enhancement kn-keyword=Enhancement en-keyword=甲状腺リンパ造影 kn-keyword=甲状腺リンパ造影 en-keyword=エコーレベル kn-keyword=エコーレベル END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=11-12 article-no= start-page=1009 end-page=1017 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on chemotherapy for malignant lymphoma Part 1. Salvage chemotherapy for non-Hodgkin's lymphoma ; MEPP : Combination of mitoxantrone, etoposide, cisplatin and prednisolone kn-title=悪性リンパ腫の化学療法に関する研究　第1編　Mitoxantrone, Etoposide, Cisplatin, Prednisolone 併用療法(MEPP) による non-Hodgkin's lymphoma の salvage 治療の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty six patients with non-Hodgkin's lymphoma (NHL), who failed to achieve complete remission or had relapsed after conventional chemotherapy (CHOP or CHOP-Bleo) were treated with a four-drug combination of mitoxantrone, etoposide, cisplatin and prednisolone (MEPP). Of 24 patients evaluated, five (21%) achieved complete remission and seven (29%) responded partially. The median duration of remission was 25 weeks, 38 weeks for complete responders (CRs), 24 weeks for partial responders (PRs). The median survival time after initiation of therapy was 93 weeks for CRs, 50 weeks for PRs and 25 weeks for non-responders (NRs). The difference in survival time between CRs and NRs was statistically significant. Myelosuppression was the major dose-limiting toxicity ; WBC nadir below 1,000/μl occurred in 66.2% of evaluable courses. Two patients with bone marrow involvement died of infection due to granulocytopenia. Renal toxicity of cisplatin was moderate and there was no cardiotoxicity of mitoxantrone detected. Despite severe myelotoxicity, these results indicate that MEPP regimen is useful as a salvage therapy for relapsed or refractory NHL. en-copyright= kn-copyright= en-aut-name=UenoKunio en-aut-sei=Ueno en-aut-mei=Kunio kn-aut-name=上野邦夫 kn-aut-sei=上野 kn-aut-mei=邦夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=非ホジキンリンパ腫 kn-keyword=非ホジキンリンパ腫 en-keyword=salvage 治療 kn-keyword=salvage 治療 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=409 end-page=417 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of pre-and postthoracotomy exercise tolerance test with a bicycle ergometer kn-title=開胸手術前後における運動負荷試験の評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Forty patients were subjected to multi-stage exercise tolerance tests using a bicycle ergometer prior to thoracotomy. During the test, expiratory gases were analyzed, and the arterial blood gas level and lactic acid level were studied. Postoperative complications were found in 10 of 40 cases (25%). Significant differences between patients with and patients without postoperative complications were recognized in VO(2)max, VCO(2)max and PaO(2)max. Patients with a VO(2)max value less than 1100 ml/min after the exercise test with a bicycle ergometer had a high risk of developing postoperative complications. Twelve postthoracotomy patients underwent the same test. All of their VO(2)max values were significantly lower than the corresponding preoperative values. en-copyright= kn-copyright= en-aut-name=KanetoSatoru en-aut-sei=Kaneto en-aut-mei=Satoru kn-aut-name=金藤悟 kn-aut-sei=金藤 kn-aut-mei=悟 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=開胸手術 kn-keyword=開胸手術 en-keyword=心肺予備能力 kn-keyword=心肺予備能力 en-keyword=運動負荷試験 kn-keyword=運動負荷試験 en-keyword=術後合併症 kn-keyword=術後合併症 en-keyword=最大酸素摂取量 kn-keyword=最大酸素摂取量 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=391 end-page=399 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Neutrophil chemotactic factors induced by OK-432 in the treatment of malignant pleural effusion kn-title=癌性胸膜炎胸水中の好中球遊走因子に関する研究―溶連菌製剤OK-432による好中球遊走因子の誘導― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the mechanism of neutrophil migration into the pleural effusion in patients undergoing intrapleural immunotherapy with the streptococal agent OK-432 for malignant pleurisy, we examined the levels of neutrophil chemotactic factor in the pleural fluid. Pleural fluid was collected before and after instillation of OK-432 in 19 patients with lung cancer, one with breast cancer, and one with gastric cancer. First we evaluated the neutrophil chemotactic activity measured by Byoden's method and the change of the cellular compositition of pleural fluid. Neutrophil chemotactic activity was significantly increased 6 hours after the instillation of OK-432, as were the differential neutrophil count and the absolute number of neutrophils. Moreover, there was a close correlation between the absolute neutrophil count and the neutrophil chemotactic activity. We also measured the levels of complement compo-nent C5a and interleukin-8 (IL-8), which are thought to be neutrophil chemotactic factor, before and after intrapleural injection of OK-432. The IL-8 and C5a levels were significantly elevated after OK-432 injection. The change of the IL-8 level was associated with a marked increase both in the neutrophil chemotactic activity and in the neutrophil absolute count. In addition, we evaluated the cytokine levels (IL-1β, IL-6 and soluble interleukin-2 receptor) of pleural fluid before and after OK-432 treatment. The OK-432 treatment induced a marked increase in the levels of IL-1β and IL-6. However, the pleural fluid level of sIL-2R was not significantly elevated, although it was significantly higher than the serum level. These findings suggest that OK-432 intrapleural injection induces neutrophil chemotactic factors (IL-8 and C5a) and cytokines (IL-1β and Il-6), which attracts neutrophils into the pleural space, which may be involved in the mechanism of the sclerosing effect of OK-432. en-copyright= kn-copyright= en-aut-name=MorishitaRyouji en-aut-sei=Morishita en-aut-mei=Ryouji kn-aut-name=森下亮二 kn-aut-sei=森下 kn-aut-mei=亮二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=malignant pleural effusin kn-keyword=malignant pleural effusin en-keyword=OK-432 kn-keyword=OK-432 en-keyword=neutrophil chemotactic factor kn-keyword=neutrophil chemotactic factor en-keyword=C5a kn-keyword=C5a en-keyword=IL-8 kn-keyword=IL-8 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=317 end-page=322 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hemodialysis membrane with a negative charge : Modeling glomerular basement membrane kn-title=腎糸球体基底膜をモデルとした理想的な透析膜作製に関する基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The glomerular basement membrane (GBM) regulates protein permeability by acting as both a size barrier and charge barrier. Since heparan sulfate-proteoglycan (HS-PG) which forms the charge barrier of the GBM contains a sulfonic acid base, we prepared negatively charged membranes by adding a sulfonic acid base to EVAL (ethylene vinyl alcohol) membranes. The permeabilities os the various proteins in these membranes were compared with those of conventional neutrally charged EVAL membranes. The permselectivity for proteins of negatively charged EVAL membranes depends largely upon the interrelation between the pore size of the membranes and size of the proteins. The negatively charged EVAL membranes had a higher selective permeability than the conventional neutrally charged EVAL membranes. Therefore, a negative charge within the dialyzer might produce higher selective permeability than conventional dialyzers. en-copyright= kn-copyright= en-aut-name=NagakeYoshio en-aut-sei=Nagake en-aut-mei=Yoshio kn-aut-name=長宅芳男 kn-aut-sei=長宅 kn-aut-mei=芳男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科学教室 en-keyword=透析膜 kn-keyword=透析膜 en-keyword=腎糸球体基底膜 kn-keyword=腎糸球体基底膜 en-keyword=size barrier kn-keyword=size barrier en-keyword=charge barrier kn-keyword=charge barrier en-keyword=スルホン酸基 kn-keyword=スルホン酸基 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=253 end-page=259 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Improvement of anemia by erythropoietin and changes in hemodialysis efficiency kn-title=エリスロポエチン投与による貧血改善と透析効率の変化に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The administration of recombinant human erythropoietin (EPO) has considerably improved renal anemia in benodialysis patients. However, there is a possibility that plasma flow will decrease and cause a reduction of hemodialysis effciency after the improvement of anemia. In the present study, we examined the influence of the improvement of anemia EPO administration on the efficiency of dialysis in 44 hemodialysis patients with renal anemia (21 males and 23 females ; mean age : 59.5±14.6 years). Epo was administered at a dose of 3,000 units three times a week and the duration of treatment was generally 12 weeks. EPO treatment significantly improved anemia. However, the blood urea nitrogen, creatinine, and uric acid levels before and after dialysis as well as the potassium and phosporus levels before dialysis showed no significant changes after the improvement of renal anemia. Accordingly. it is unnecessary to take any specific measures to improve the efficiency of dialysis after treating renal anemia with EPO. en-copyright= kn-copyright= en-aut-name=MakinoHirohumi en-aut-sei=Makino en-aut-mei=Hirohumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=1 ORCID= en-aut-name=NagakeYoshio en-aut-sei=Nagake en-aut-mei=Yoshio kn-aut-name=長宅芳男 kn-aut-sei=長宅 kn-aut-mei=芳男 aut-affil-num=2 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name=小倉俊郎 kn-aut-sei=小倉 kn-aut-mei=俊郎 aut-affil-num=3 ORCID= en-aut-name=HaramotoToshinori en-aut-sei=Haramoto en-aut-mei=Toshinori kn-aut-name=原本俊則 kn-aut-sei=原本 kn-aut-mei=俊則 aut-affil-num=4 ORCID= en-aut-name=MatsumotoMitsuhito en-aut-sei=Matsumoto en-aut-mei=Mitsuhito kn-aut-name=松本光仁 kn-aut-sei=松本 kn-aut-mei=光仁 aut-affil-num=5 ORCID= en-aut-name=HaramatsuMakoto en-aut-sei=Haramatsu en-aut-mei=Makoto kn-aut-name=平松信 kn-aut-sei=平松 kn-aut-mei=信 aut-affil-num=6 ORCID= en-aut-name=MinoYasuaki en-aut-sei=Mino en-aut-mei=Yasuaki kn-aut-name=味埜泰明 kn-aut-sei=味埜 kn-aut-mei=泰明 aut-affil-num=7 ORCID= en-aut-name=NishimuraShigeaki en-aut-sei=Nishimura en-aut-mei=Shigeaki kn-aut-name=西村誠明 kn-aut-sei=西村 kn-aut-mei=誠明 aut-affil-num=8 ORCID= en-aut-name=TaniaiKazuhi en-aut-sei=Taniai en-aut-mei=Kazuhi kn-aut-name=谷合一陽 kn-aut-sei=谷合 kn-aut-mei=一陽 aut-affil-num=9 ORCID= en-aut-name=KumagaiIsao en-aut-sei=Kumagai en-aut-mei=Isao kn-aut-name=熊谷功 kn-aut-sei=熊谷 kn-aut-mei=功 aut-affil-num=10 ORCID= en-aut-name=KomotoKiichi en-aut-sei=Komoto en-aut-mei=Kiichi kn-aut-name=河本紀一 kn-aut-sei=河本 kn-aut-mei=紀一 aut-affil-num=11 ORCID= en-aut-name=TakehisaYoshiaki en-aut-sei=Takehisa en-aut-mei=Yoshiaki kn-aut-name=竹久義明 kn-aut-sei=竹久 kn-aut-mei=義明 aut-affil-num=12 ORCID= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=13 ORCID= en-aut-name=SugaYoshihiko en-aut-sei=Suga en-aut-mei=Yoshihiko kn-aut-name=菅嘉彦 kn-aut-sei=菅 kn-aut-mei=嘉彦 aut-affil-num=14 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第三内科学教室 affil-num=5 en-affil= kn-affil=尾道市立市民病院内科 affil-num=6 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=7 en-affil= kn-affil=落合病院内科 affil-num=8 en-affil= kn-affil=岡山中央病院内科 affil-num=9 en-affil= kn-affil=岡山中央病院内科 affil-num=10 en-affil= kn-affil=寺岡記念病院腎センター affil-num=11 en-affil= kn-affil=因島総合病院内科 affil-num=12 en-affil= kn-affil=鳥取市立病院内科 affil-num=13 en-affil= kn-affil=姫路第一病院内科 affil-num=14 en-affil= kn-affil=菅病院内科 affil-num=15 en-affil= kn-affil=岡山大学医学部第三内科学教室 en-keyword=腎性貧血 kn-keyword=腎性貧血 en-keyword=エリスロポエチン kn-keyword=エリスロポエチン en-keyword=透析効率 kn-keyword=透析効率 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=11-12 article-no= start-page=903 end-page=918 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Leukemic cell destruction kinetics in bone marrow kn-title=急性白血病寛解導入療法における骨髄内白血病細胞減少動態に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=An equation was developed to describe the kinetics of leukemic cell destruction in bone marrow during induction chemotherapy for acute nonlymphocytic leukemia (logZ＝K(1)t(4)＋K(2)t(3)＋K(3)t(2)＋K(4), where Z＝leukemic cell number, t＝time, and K＝a constant). The leukemic cell destruction curve was biphasic ; phase Ⅰ was the period from the initiation of a decrease in cells to the maximum velocity of the decrease, and phase Ⅱ was the subsequent period to the cessation of decrease. The following parameters were established : duration and acceleration of decrease in phases Ⅰ and Ⅱ, maximum velocity of decrease, duration of reduction, and residual volume of leukemic cells. 1. Patients who achieved CR showed a longer duration of phases Ⅰ and Ⅱ, a lower acceleration of the decrease in phase Ⅱ, and smaller residual leukemic cell volume than patients who did not achieve CR. there were no significant differences of parameters related to FAB classification, type of induction therapy, or the age of the patients. 2. This equation could be adapted to explain erythroblast kinetics during induction chemotherapy. There were no significant differences of the parameters with respect to the effect of induction therapy and patient age. 3. Patients with high acceleration of the decrease in phase Ⅱ had a short duration of CR and survival. The leukemic cell destruction curve was thought to be useful not only for evaluation of the effect of induction therapy, but also for establishment of post-remission chemotherapy. en-copyright= kn-copyright= en-aut-name=TakeuchiMakoto en-aut-sei=Takeuchi en-aut-mei=Makoto kn-aut-name=竹内誠 kn-aut-sei=竹内 kn-aut-mei=誠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=acute leukemia kn-keyword=acute leukemia en-keyword=leukemic cell destruction curve kn-keyword=leukemic cell destruction curve en-keyword=leukemic cell destruction kinetics kn-keyword=leukemic cell destruction kinetics en-keyword=remission induction chemotherapy kn-keyword=remission induction chemotherapy END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=87 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of allergic gastroenteropathy Part 1. Diagnostic application of abdominal ultrasonography during an antigen oral loading test kn-title=アレルギー性胃腸症の病態に関する研究 第1編 腹部超音波走査法による抗原経口負荷試験に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Pathogenesis of allergic gastroenteropathy involves various antigen-mediated allergic reactions through a defensive mechanism of the digestive tract. The conventional method of the diagnosis generally involves the exclusion-provocation test of causative food and the judgement based on only subjective symptoms. A diagnostic method based on objective parameters has not been established yet. To establish an objective diagnostic method, ultrasonography was applied to 3 patients in whom chicken eggs and milk had been clinically diagnosed as the antigens during the oral loading test of appropriate antigen extract. After oral loading of the causative antigen extract, the gastric movements were observed by ultrasonography from 30 minutes before loading until 120 minutes after loading. The total number of peristaltic movements were then measured during every 30 minuites as an indicator of acceleration of gastric peristalic movenents. All 3 cases showed a marked acceleration of gastric peristaltic movements as well as several abdominal symptoms such as abdominal pain and diarrhea at 30 to 60 minuites after loading the antigen. These findings indicate that this method may be useful in the diagnosis of allergic gastroenteropathy. en-copyright= kn-copyright= en-aut-name=ToyotaYuji en-aut-sei=Toyota en-aut-mei=Yuji kn-aut-name=豊田裕治 kn-aut-sei=豊田 kn-aut-mei=裕治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=アレルギー性胃腸症 kn-keyword=アレルギー性胃腸症 en-keyword=経口負荷試験 kn-keyword=経口負荷試験 en-keyword=超音波走査法 kn-keyword=超音波走査法 en-keyword=好酸球性胃腸症 kn-keyword=好酸球性胃腸症 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=73 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of anthracycline-anthraquinone analogues in the treatment of lung cancer using colony assay Part 1. Comparison of antitumor activity of anthracycline-anthraquinone analogues in human lung cancer cell lines kn-title=Colony assay 法を用いた肺癌化学療法における Anthracycline-anthraquinone 系薬剤の有効性に関する研究 第1編 ヒト肺癌細胞株に対する Anthracycline-anthraquinone 系薬剤の殺細胞効果の比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In an attempt to evaluate the antitumor activity of new anthracycline-anthraquinone analogues ; aclarubicin (ACR), tetrahydropyranyl adriamycin (THP-ADM), and mitoxantrone(MIT), these analogues were compared with adriamycin(ADM) in terms of 70% lethal dose by colony assay using five human lung cancer cell lines, which had been established and maintained in our laboratory. The human lung cancer cell lines tested were EBC-1, an epidermoid cancer cell line, ABC-1, an adenocarcinoma cell line, and SBC-1, -2, and -3, small cell cancer cell lines. In general, the EBC-1 established from a patient tumor showing resistance to ADM was the least sensitive to the drugs tested, and SBC-3 established from a patient tumor with no prior chemotherapy was the most sensitive to the drugs. In antitumor activity, both ACR and THP-ADM appeared to be superior to ADM and MIT, suggesting the clinical usefulness of these drugs in the treatment of lung cancer. en-copyright= kn-copyright= en-aut-name=NumataTakeyuki en-aut-sei=Numata en-aut-mei=Takeyuki kn-aut-name=沼田健之 kn-aut-sei=沼田 kn-aut-mei=健之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=肺癌細胞株 kn-keyword=肺癌細胞株 en-keyword=colony assay kn-keyword=colony assay en-keyword=anthracycline kn-keyword=anthracycline en-keyword=anthraquinone kn-keyword=anthraquinone END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=29 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Colorectal carcinoma in aged patients over 75 years old : Clinicopathological study kn-title=高齢者大腸癌切除例の臨床病理学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In a review of 358 patients with colorectal carcinoma resected at the department during the past 13 years between 1978 and 1990, 41 elderly patients over 75 years old were selected (served as aged group) and compared to younger patients under 74 years old (younger group) for clinicopathological features and prognosis. Elderly patients, who represented 11.5% of all cases, were predominantly females. There was no significant difference in the localization of the tumor, depth of invasion, lymphnode metastasis and lymphatic infiltration between the two groups. No significant difference was noted in macroscopic type, but a tendency of having type 5 was observed in the elderly group. The elderly group had a significantly smaller maximum diameter of the tumor. There was a lower tendency in the positive rate of vessel invasion in the elderly group. In the stage classification and the incidence of curative resection, there were no differences between the two groups. The cumulative survical rate after resection in the elderly group was relatively lower than that in the other group. en-copyright= kn-copyright= en-aut-name=KurodaMuneaki en-aut-sei=Kuroda en-aut-mei=Muneaki kn-aut-name=黒田宗明 kn-aut-sei=黒田 kn-aut-mei=宗明 aut-affil-num=1 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=2 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=3 ORCID= en-aut-name=KimuraToshikazu en-aut-sei=Kimura en-aut-mei=Toshikazu kn-aut-name=木村臣一 kn-aut-sei=木村 kn-aut-mei=臣一 aut-affil-num=4 ORCID= en-aut-name=NonakaYasuyuki en-aut-sei=Nonaka en-aut-mei=Yasuyuki kn-aut-name=野中泰幸 kn-aut-sei=野中 kn-aut-mei=泰幸 aut-affil-num=5 ORCID= en-aut-name=NezuMasashi en-aut-sei=Nezu en-aut-mei=Masashi kn-aut-name=根津真司 kn-aut-sei=根津 kn-aut-mei=真司 aut-affil-num=6 ORCID= en-aut-name=YoshinagaMasao en-aut-sei=Yoshinaga en-aut-mei=Masao kn-aut-name=吉永昌雄 kn-aut-sei=吉永 kn-aut-mei=昌雄 aut-affil-num=7 ORCID= en-aut-name=JikuharaAtsushi en-aut-sei=Jikuhara en-aut-mei=Atsushi kn-aut-name=軸原温 kn-aut-sei=軸原 kn-aut-mei=温 aut-affil-num=8 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=9 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=高齢者 kn-keyword=高齢者 en-keyword=大腸癌 kn-keyword=大腸癌 en-keyword=切除症例 kn-keyword=切除症例 en-keyword=臨床病理学的検討 kn-keyword=臨床病理学的検討 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=11-12 article-no= start-page=1125 end-page=1142 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Possible anti-tumor effects of drug-induced splenectomy with cyclophosphamide and indomethacin, and surgical splenectomy in combination with immunochemotherapy in tumor-bearing mice and gastric cancer patients kn-title=担癌マウスならびに胃癌患者における Cyclophosphamide と Indomethacin による薬物学的摘脾効果の可能性，および外科的摘脾と免疫化学療法併用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using tumor-bearing C(3)H/He mice, in which syngeneic MH-134 tumor cells were transplanted into the back subcutaneously, the possibility of drug-induced splenectomy using cyclophosphamide (CY) and indomethacin (INDO), the timing of chemo- and immuno-therapy, and the usefulness of the combination of surgical splenectomy with immunotherapy were investigated. In patients with gastric cancer, the significance of splenectomy and its combination with immunochemotherapy was also studied. The administration of CY in mice on day 3 after tumor transplantation in the initial stage of the tumor prolonged the survival time, while INDO under the same condition shortened it only when administered on day 3 after transplantation. The administration of an immunopotentiator, OK-432, prior to CY administration shortened the survival time, compared with that of single administration of CY, whereas the OK-432 administration on day 2 after the administration of CY prolonged the survival time. In the immunochemotherapy in which CY was administered on day 7 after transplantation of tumor and OK-432 was given every two days after additional 2 days, the anti-tumor effect of drug-induced splenectomy was not observed as judged from the tumor proliferating curve, but the splenectomy on day 3 after tumor transplantation, in the initial stage of the tumor, prolonged tne survival time. Similar results were observed, when INDO was used instead of CY. The concomitant splenectomy in the initial stage of gastric cancer resulted in a more effective prolongation of survival time. In the cases with adjuvant immunochemotherapy, preservation of the spleen in advanced cancer and splenectomy in the terminal stage of cancer were found to be preferable for effective prolongation of the survival time. en-copyright= kn-copyright= en-aut-name=YuiJiro en-aut-sei=Yui en-aut-mei=Jiro kn-aut-name=由井治郎 kn-aut-sei=由井 kn-aut-mei=治郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=薬物学的摘脾 kn-keyword=薬物学的摘脾 en-keyword=cyclophosphamide kn-keyword=cyclophosphamide en-keyword=indomethacin kn-keyword=indomethacin en-keyword=摘脾と免疫療法 kn-keyword=摘脾と免疫療法 en-keyword=摘脾と免疫化学療法 kn-keyword=摘脾と免疫化学療法 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=861 end-page=874 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cell cycle in myelodysplastic syndrome kn-title=骨髄異形成症候群における骨髄細胞周期に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bone marrow cell cycle analysis was performed on 23 patients with myelodysplastic syndrome (MDS)[12 with refractory anemia(RA), two with RA with ringed sideroblasts(RARS), three with RA with excess blasts(RAEB), six with RAEB in transformation(RAEBt)], and 14 normal volunteers. Cells were stained with propidium iodide and analyzed by flow-cytometry. Patients with RA and RARS (low-risk MDS) showed higher rates of S-phase (21.2±4.9%) and patients with RAEB and RAEBt (high-risk MDS) showed lower rates of S-phase (9.9±5.9%) compared with normal controls (15.2±3.1%). Although the rate of S-phase decreased with disease progression, it was normalized with complete remission. An intermediate correlation (r=0.64, p<0.01) existed between the rate of S-phase and the percentage of erythroblasts in MDS. The rate of S-phase clearly reflects the severity of MDS. The high rate of S-phase in low risk MDS was concidered to be due to erythroid hyperplasia with ineffective hematopoiesis. en-copyright= kn-copyright= en-aut-name=TanimizuMasakuni en-aut-sei=Tanimizu en-aut-mei=Masakuni kn-aut-name=谷水将邦 kn-aut-sei=谷水 kn-aut-mei=将邦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Myelodysplastic syndrome kn-keyword=Myelodysplastic syndrome en-keyword=Flowcytometry kn-keyword=Flowcytometry en-keyword=Cell cycle analysis kn-keyword=Cell cycle analysis en-keyword=Erythroid hyperplasia kn-keyword=Erythroid hyperplasia en-keyword=Ineffective hematopoiesis kn-keyword=Ineffective hematopoiesis END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=11-12 article-no= start-page=333 end-page=342 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical, radiographic, and histological studies on rapidly destructive coxopathy kn-title=急速破壊型股関節症の病態に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical and radiological studies were performed on 25 hips of 25 patients with rapidly destructive coxopathy within 3 years after the onset. The mean age at the time of onset was 68.3 years. Two patients were males, and the other 23 were females ; many patients were aged females. The mean Japanese Orthopaedic Association hip score for pain was 13/40 while that for the range of motion (flexion) was 9.4/12. Inspite of marked pain, the motion range was relatively good. The mean disease duration was 10.3 months in the group showing an increased blood sedimentation rate and 20.8 months in the group with a normal sedimentation rate, being shorter in the former showing positive inflammatory reactios. Hypertension was observed in 44%. Radiographic examination showed osteoporosis in all patients. According to Singh's classification, the disease duration was shorter in patients with advanced osteoporosis. The Center-Edge angle and Acetabular-Head Index as the acetabular covering rate were below the mean value in 65%, showing slight dysplasia of hip joint. Histopathological examination revealed exposure of eburnated bone on the surface of the capital lesion in many patients, but only slight proliferative changes. In the synovial membrane, villous hyperplasia and cell proliferation were observed in the surface layer in most of patients. Free fragments of the cartilage and bone were phagositized with nonspecific inflammatory findings in the deep layer. en-copyright= kn-copyright= en-aut-name=IwasakiHiromitsu en-aut-sei=Iwasaki en-aut-mei=Hiromitsu kn-aut-name=岩崎裕光 kn-aut-sei=岩崎 kn-aut-mei=裕光 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科学教室 en-keyword=rapidly destructive coxopathy kn-keyword=rapidly destructive coxopathy en-keyword=osteoarthrosis kn-keyword=osteoarthrosis en-keyword=bone necrosis kn-keyword=bone necrosis END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=751 end-page=756 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of esophageal cyst kn-title=食道囊腫の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Esophageal cyst is a relatively rare disease and about 91 cases have been reported in Japan. We report a new case of esophageal cyst. Tha patient was a 36-year-old male who complained of nausea and vomiting. We performed esophagography, endoscopy, endoxcopic echography, CT and MRI and found a cystic lesion in the lower esophagus. We made the diagnosis of an esophageal cyst and performed operation. The tumor was in the esophageal muscle but did not have a commissure to the esophageal lumen. We extirpated it with esophageal muscle and repaired the muscle defect with diaphragma. This tumor, 7.5×5.0cm in size, was a monolocular cyst and contained brown muddy material. Microscopic findings revealed a ciliated columnar epithelium and squamous epithelium in the cyst wall but cartilage was not found. The cyst was covered with double smooth muscle layers. It was difficult to differentiate an esophageal cyst from a paraesophageal bronchogenic cyst but these histological findings suggested that this cyst was an esophageal cyst. en-copyright= kn-copyright= en-aut-name=IshiiYasunori en-aut-sei=Ishii en-aut-mei=Yasunori kn-aut-name=石井泰則 kn-aut-sei=石井 kn-aut-mei=泰則 aut-affil-num=1 ORCID= en-aut-name=InoueFumiyuki en-aut-sei=Inoue en-aut-mei=Fumiyuki kn-aut-name=井上文之 kn-aut-sei=井上 kn-aut-mei=文之 aut-affil-num=2 ORCID= en-aut-name=BanHidetoshi en-aut-sei=Ban en-aut-mei=Hidetoshi kn-aut-name=伴秀利 kn-aut-sei=伴 kn-aut-mei=秀利 aut-affil-num=3 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=4 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=食道囊腫 kn-keyword=食道囊腫 en-keyword=esophageal cyst kn-keyword=esophageal cyst en-keyword=気管支食道囊腫 kn-keyword=気管支食道囊腫 en-keyword=bronchial-esophageal cyst kn-keyword=bronchial-esophageal cyst en-keyword=foregut cyst kn-keyword=foregut cyst END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=731 end-page=742 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the occurrence of bronchial asthma Part 1. Human leukocyte antigen as a genetic factor kn-title=気管支喘息の発症に関する研究　第1編　喘息患者における HLA による遺伝的要因の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Heredity has long been suspected to play an important role in the occurrence of bronchial asthma. Recently familial and twin sibling studies demonstrated the role of genetic factors in asthma. Therefore, we measured HLA antigens of 53 asthmatics and analyzed the relationship to clinical parameters to elucidate the role of HLA in the occurrence of bronchial asthma. Four major findings were obtained. 1) Study of the HLA system in asthmatics showed a significantly higher frequency of DR53 and DQ3 and lower frequency of DQ1, DQ6 (1) and DQ7(3). This suggests that DR molecules demonstrate positive associations and DQ molecules negative associations with bronchial asthma. 2) DQ1 was associated with IgE production in asthmatics. 3) B39(16) positively associated with RAST score of Candida. 4) The study of late onset asthmatics, intractable asthmatics and the high responder group of in vitro lymphocyte reaction to Candida allergen showed a cooperatively and significantly higher frequency of DR53(P<0.05). These findings suggest that DR53 has a positive association with onset of late onset intractable asthma. en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=late onset intractable asthma kn-keyword=late onset intractable asthma en-keyword=HLA kn-keyword=HLA en-keyword=Candida antigen kn-keyword=Candida antigen en-keyword=IgE kn-keyword=IgE END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=7-8 article-no= start-page=225 end-page=240 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spectrum analysis of arterial blood pressure waveforms kn-title=動脈圧波形の形状変化に対する周波数解析による検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is known that the shape of arterial blood pressure waveform reflects the hemodynamic status, but quantitative analyses of waveform are seldom reported. In this study, the arterial pressure wave was recorded with an intra-arterial catheter and pressure transducer, converted to digital data, and stored in a computer. The data were analyzed by two methods of spectrum analyses, i.e., fast Fourier transform (FFT for both power spectrum and phase information) and the autoregressive model (ARM). Pressure waveforms during normotension were compared with pressure waveforms during hypotension induced by vasodilators (sodium nitroprusside and nitroglycerin) in the human study, and by the vasodilators, hemorrhage or 3% isoflurane in the animal study. Reconstruction of waveforms by inverse FFT was also performed, and compared with the original waveforms. FFT is more useful than ARM for analysis of data with known frequencies, such as respiratory and heart rates. Using inverse FFT, the wave can be reconstructed by the base frequency (heart rate) to 4th harmonic data with an error margin of less than 2%. The amplitude and phase information of heart rate frequency up to its 4th harmonic, and amplitude of respiratory frequency, were found to be the essential parameters to describe the shape of the arterial pressure waveform. en-copyright= kn-copyright= en-aut-name=SaitoTomohiko en-aut-sei=Saito en-aut-mei=Tomohiko kn-aut-name=齋藤智彦 kn-aut-sei=齋藤 kn-aut-mei=智彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=動脈圧波形 kn-keyword=動脈圧波形 en-keyword=周波数解析 kn-keyword=周波数解析 en-keyword=フーリエ変換 kn-keyword=フーリエ変換 en-keyword=自己回帰モデル kn-keyword=自己回帰モデル END start-ver=1.4 cd-journal=joma no-vol=111 cd-vols= no-issue=1-2 article-no= start-page=11 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bacteriological and molecular epidemiological investigation on nosocomial infection caused by Methicillin-resistant Staphylococcus aureus and its pervention kn-title=MRSA 院内感染の細菌学的・分子疫学的調査と感染予防対策 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The colonization of methicillin-resistant Staphylococcus aureus (MRSA) was investigated in a private hospital three times for one year in an attempt to prevent the MRSA transmission. Total 22 MRSA strains were isolated. The pulse field gel electrophoresis (PFGE) was performed to investigate the route of transmission (infection way) in addition to characterize their bacteriological properties. Since the PFGE profiles were identical or very similar between the strain isolated from a patient and those from several nurses' hands and clothing cared for patient, the standard precautions including handwashing and gown technique have been performed. No transmission of MRSA through medical staff has been investigated in this hospital aftreward. Therefore, it was confirmed that the epidemiological investigation and its educational direction contribute to prevent the nosocomical infection of MRSA. en-copyright= kn-copyright= en-aut-name=SendaYoshiko en-aut-sei=Senda en-aut-mei=Yoshiko kn-aut-name=千田好子 kn-aut-sei=千田 kn-aut-mei=好子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学講座 en-keyword=MRSA kn-keyword=MRSA en-keyword=院内感染対策 kn-keyword=院内感染対策 en-keyword=PFGE法 kn-keyword=PFGE法 END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=155 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic cholecystectomy in 3 cases of hemodialysis patients kn-title=透析患者における腹腔鏡下胆囊摘出術の経験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Laparoscopic cholecystectomy has proven to be a safe and effective treatment for symptomatic gall stone disease. However, laparoscopic cholecystectomy in hemodialysis patients is considered to be relatively contraindicated because of anemia and bleeding tendency. We performed laparoscopic cholecystectomy in three patients being treated by hemodialysis for chronic renal failure. No significant complications were observed after surgery. Laparoscopic cholecystectomy should be considered for hemodialysis patients requiring cholecystectomy. en-copyright= kn-copyright= en-aut-name=TakaiKenichi en-aut-sei=Takai en-aut-mei=Kenichi kn-aut-name=高井研一 kn-aut-sei=高井 kn-aut-mei=研一 aut-affil-num=1 ORCID= en-aut-name=TaniaiKazuhi en-aut-sei=Taniai en-aut-mei=Kazuhi kn-aut-name=谷合一陽 kn-aut-sei=谷合 kn-aut-mei=一陽 aut-affil-num=2 ORCID= en-aut-name=TakatoriKatsuhiko en-aut-sei=Takatori en-aut-mei=Katsuhiko kn-aut-name=高取克彦 kn-aut-sei=高取 kn-aut-mei=克彦 aut-affil-num=3 ORCID= en-aut-name=OhtaSachiko en-aut-sei=Ohta en-aut-mei=Sachiko kn-aut-name=大田祥子 kn-aut-sei=大田 kn-aut-mei=祥子 aut-affil-num=4 ORCID= en-aut-name=KunitomiMie en-aut-sei=Kunitomi en-aut-mei=Mie kn-aut-name=国富三絵 kn-aut-sei=国富 kn-aut-mei=三絵 aut-affil-num=5 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=6 ORCID= en-aut-name=KuroseMasao en-aut-sei=Kurose en-aut-mei=Masao kn-aut-name=黒瀬匤雄 kn-aut-sei=黒瀬 kn-aut-mei=匤雄 aut-affil-num=7 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山中央病院内科 affil-num=2 en-affil= kn-affil=岡山中央病院内科 affil-num=3 en-affil= kn-affil=岡山中央病院内科 affil-num=4 en-affil= kn-affil=岡山中央病院内科 affil-num=5 en-affil= kn-affil=岡山中央病院内科 affil-num=6 en-affil= kn-affil=岡山中央病院外科 affil-num=7 en-affil= kn-affil=岡山中央病院外科 affil-num=8 en-affil= kn-affil=岡山中央病院外科 en-keyword=腹腔鏡下胆囊摘出術 kn-keyword=腹腔鏡下胆囊摘出術 en-keyword=透析 kn-keyword=透析 END start-ver=1.4 cd-journal=joma no-vol=110 cd-vols= no-issue=7-10 article-no= start-page=107 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19981030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Case report of a gastric glomus tumor kn-title=胃癌を伴った胃グロームス腫瘍の1例―本邦報告例の文献的考察― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The patient was a 67-year-old man who vomitted blood during therapy while hospitalized due to an asthma attack. He underwent a gastric examination, which detected a submucosal tumor on the greater curvature of the gastric antrum and gastric cancer on the lesser curvature. This tumor was diagnosed as a glomus tumor by postoperative pathological examination. In Japan, glomus tumors of stomach have been reported in 50 cases including our case. The mean age of patients was 48 years (23 to 74). Nineteen patients were male and 31 female. The main symptom was upper abdominal pain. The tumors developed in the submucosal layer of the greater curvature in the antrum and the mean size was 2.8 cm. A Angiography revealed hypervascularization and endoscopic ulutasonography showed spheroid tumors localized in the muscle layer. Proeoperative histological diagnoses were often difficult. Two cases including our patient were associated with gastric cancer. en-copyright= kn-copyright= en-aut-name=FukudaKazuma en-aut-sei=Fukuda en-aut-mei=Kazuma kn-aut-name=福田和馬 kn-aut-sei=福田 kn-aut-mei=和馬 aut-affil-num=1 ORCID= en-aut-name=AsanoHiroaki en-aut-sei=Asano en-aut-mei=Hiroaki kn-aut-name=浅野博昭 kn-aut-sei=浅野 kn-aut-mei=博昭 aut-affil-num=2 ORCID= en-aut-name=OtaniYuu en-aut-sei=Otani en-aut-mei=Yuu kn-aut-name=大谷裕 kn-aut-sei=大谷 kn-aut-mei=裕 aut-affil-num=3 ORCID= en-aut-name=MiyagutiNaoyuki en-aut-sei=Miyaguti en-aut-mei=Naoyuki kn-aut-name=宮口直之 kn-aut-sei=宮口 kn-aut-mei=直之 aut-affil-num=4 ORCID= en-aut-name=NishiHideyuki en-aut-sei=Nishi en-aut-mei=Hideyuki kn-aut-name=西英行 kn-aut-sei=西 kn-aut-mei=英行 aut-affil-num=5 ORCID= en-aut-name=ManoMasayuki en-aut-sei=Mano en-aut-mei=Masayuki kn-aut-name=間野正之 kn-aut-sei=間野 kn-aut-mei=正之 aut-affil-num=6 ORCID= en-aut-name=KomatubaraShoukiti en-aut-sei=Komatubara en-aut-mei=Shoukiti kn-aut-name=小松原正吉 kn-aut-sei=小松原 kn-aut-mei=正吉 aut-affil-num=7 ORCID= en-aut-name=KishimotoTakumi en-aut-sei=Kishimoto en-aut-mei=Takumi kn-aut-name=岸本卓巳 kn-aut-sei=岸本 kn-aut-mei=卓巳 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山労災病院外科 affil-num=2 en-affil= kn-affil=岡山労災病院外科 affil-num=3 en-affil= kn-affil=岡山労災病院外科 affil-num=4 en-affil= kn-affil=岡山労災病院外科 affil-num=5 en-affil= kn-affil=岡山労災病院外科 affil-num=6 en-affil= kn-affil=岡山労災病院外科 affil-num=7 en-affil= kn-affil=岡山労災病院外科 affil-num=8 en-affil= kn-affil=岡山労災病院内科 en-keyword=胃グロームス腫瘍 kn-keyword=胃グロームス腫瘍 en-keyword=胃癌 kn-keyword=胃癌 en-keyword=Gastric Glomus Tumor kn-keyword=Gastric Glomus Tumor END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=71 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Prevention of peritoneal dissemination and serosal invasion of digestive tract cancer in an experimental murine model kn-title=癌漿膜浸潤および腹膜播種の防止に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a novel prophylactic strategy for peritoneal dissemination and serosal invasion of digestive tract cancer in a murine model, in which the murine abdominal wall was compared to the wall of the human digestive tract. Subcutaneous injection of MH-134 cells to the abdominal wall of C3H mice induced tumors on the parietal peritoneum, and eventually caused peritoneal dissemination with time. In this model, the intraperitoneal administration of OK-432, a type of biological response modifier, after tumor implantation significantly inhibited the development of peritoneal dissemination of tumor cells. This effect was more profound in mice with tumors that extended to the peritoneal surface (designated as S1 stage). Histological examination revealed both the remarkable necrosis of tumoral tissue and the formation of a collagen fiber at the edge of the tumor. This antitumoral effect of OK-432 is thought to be mediated by both macrophages and lymphocytes migrated into the peritoneal cavity, because the administration of Carrageenan and anti-lymphocyte serum completely blocked the antitumoral effect of OK-432. en-copyright= kn-copyright= en-aut-name=IijimaTakashi en-aut-sei=Iijima en-aut-mei=Takashi kn-aut-name=飯島崇史 kn-aut-sei=飯島 kn-aut-mei=崇史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=漿膜浸潤 kn-keyword=漿膜浸潤 en-keyword=腹膜播種性転移 kn-keyword=腹膜播種性転移 en-keyword=OK-432 kn-keyword=OK-432 en-keyword=細胞性間質反応 kn-keyword=細胞性間質反応 en-keyword=線維性間質反応 kn-keyword=線維性間質反応 END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=9-12 article-no= start-page=169 end-page=182 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20001225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study on the relationship between bone mineral density and life style using quantitayive ultrasound imaging kn-title=超音波測定法による「骨密度検診」の有用性と生活習慣との関連 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To prepare for the problems associsted with a rapidly aging society, a checkup for the bone mineral density has been performed in many cities and villages in Japan. However, there are varying methods for measuring bone mineral density, and the usefulnes of quantitative Ultrasound imaging has not been established. The relationship between bone mineral density and life style in 627 women in 5 cities was investigated using quantitative ultasound imaging to measure bone mineral density. The results can be summarized as follows: 1. The results from quantitative ultrasound imaging can be applied to the established DXA method because there was a correlation among dual energy X-ray absorptiometry. single energy X-ray absorptiometry and quantitative ultrasound imaging. 2. The stiffness index by quantitative ultrasound imaging was highly correlated with age and decreased proportinally with an increase in age. 3. We suggest that the measurement of bone mineral desity by quantitative ultrasound imaging for women at the age of 55 and 60 years in addition to those of 40 and 50 years is necessary. 4. We speculate that exercise and celcinm intake during youth have some effects on bone mineral density of woman after the prime of life. en-copyright= kn-copyright= en-aut-name=KimuraHirotsugu en-aut-sei=Kimura en-aut-mei=Hirotsugu kn-aut-name=木村博承 kn-aut-sei=木村 kn-aut-mei=博承 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学講座 en-keyword=「骨密度検診」 kn-keyword=「骨密度検診」 en-keyword=超音波測定法 kn-keyword=超音波測定法 en-keyword=生活習慣 kn-keyword=生活習慣 END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=3-8 article-no= start-page=29 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=MRI of the knee before and after arthroscopic synovectomy in patients with rheumatoid arthritis kn-title=鏡視下滑膜切除術を行った慢性関節リウマチの膝MRI en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effectiveness of arthroscopic synovectomy (A-S) for the knee of rheumatoid arthritis (RA) patients was assesssd by comparing the severity of synovial proliferation on MRI before and after the surgery. Twenty-five patients (30 knees) were studied. The mean duration of RA was 6 years and 7 months and the mean age at the time of A-S was 49.0 years. The mean follow-up period was 19 months (range:6-39 months). The preoperative Larsen's classification from grade Ⅰto Ⅳ was 8, 13, 6, and 3 knees, resectively. Synovial proliferation was evaluated by the modified Takeuchi's classification (MRI score). The MRI score was investigated in relationships with the radiographic grade, wet weight of excised tissue, treatment score for RA knees of the Japanese Orthopaedic Association (JOA score), and the CRP value. The MRI score, JOA score, and CRP all significantly improved during follow-up. The radiographic grade showed less progression, the JOA score improved more, and CRP was lower during follow-up in patients with a postoperative MRI score less than 5. The wet weight of excised tissue showed no related with the MRI score. These results suggest that the effectiveness of A-S can be determined by evaluation of improvement of the MRI score. en-copyright= kn-copyright= en-aut-name=KatohYasuyuki en-aut-sei=Katoh en-aut-mei=Yasuyuki kn-aut-name=加藤泰之 kn-aut-sei=加藤 kn-aut-mei=泰之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科学講座 en-keyword=Rheumatoid arthritis kn-keyword=Rheumatoid arthritis en-keyword=Knee kn-keyword=Knee en-keyword=Arthroscopic synovectomy kn-keyword=Arthroscopic synovectomy en-keyword=Magnetic resonance imaging kn-keyword=Magnetic resonance imaging END start-ver=1.4 cd-journal=joma no-vol=113 cd-vols= no-issue=3 article-no= start-page=295 end-page=297 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=電子カルテ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田吉夫 kn-aut-sei=太田 kn-aut-mei=吉夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院医療情報部 en-keyword=電子カルテ kn-keyword=電子カルテ en-keyword=病院情報システム kn-keyword=病院情報システム END start-ver=1.4 cd-journal=joma no-vol=113 cd-vols= no-issue=3 article-no= start-page=261 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=性同一性障害に対する包括的医療の実践―精神科神経科での経験― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐藤俊樹 kn-aut-sei=佐藤 kn-aut-mei=俊樹 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山本文子 kn-aut-sei=山本 kn-aut-mei=文子 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡部伸幸 kn-aut-sei=岡部 kn-aut-mei=伸幸 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田順一郎 kn-aut-sei=太田 kn-aut-mei=順一郎 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大西勝 kn-aut-sei=大西 kn-aut-mei=勝 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井戸由美子 kn-aut-sei=井戸 kn-aut-mei=由美子 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=黒田重利 kn-aut-sei=黒田 kn-aut-mei=重利 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　精神神経病態学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　精神神経病態学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　精神神経病態学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　精神神経病態学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　精神神経病態学 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院生理第2検査室 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　精神神経病態学 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=225 end-page=234 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=医療における個人情報保護法 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田吉夫 kn-aut-sei=太田 kn-aut-mei=吉夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 医療情報部 en-keyword=個人情報 kn-keyword=個人情報 en-keyword=個人情報保護 kn-keyword=個人情報保護 en-keyword=プライバシー kn-keyword=プライバシー en-keyword=医療情報 kn-keyword=医療情報 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=経皮的心肺補助およびリポソーム化ヘモグロビンTRM645を併用した新規心肺蘇生法の実験的検討 kn-title=Experimental Study of a Novel Method of Cardiopulmonary Resuscitation Using a Combination of Percutaneous Cardiopulmonary Support and Liposome-encapsulated Hemoglobin (TRM645) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaKei en-aut-sei=Ota en-aut-mei=Kei kn-aut-name=太田圭 kn-aut-sei=太田 kn-aut-mei=圭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=141 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Accidents in dental treatment: A questionnaire investigation kn-title=歯科医師の就業状況と診療偶発事故 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The relationship between the operational situation of dental treatment and accidents experienced was investigated through questionnaires sent to members of the Kagawa Dental Association. Responses were received from 261 dentists (53% response rate), of whom 113 (43%) had experienced accidents during dental examinations and/or treatment during the past one year. Dentists with a particularly high risk of having accidents were predominantly young males who possessed many medical chairs at their clinic and who daily examined many patients. Those dentists who worked together with two or more colleagues had a lower risk of accidents. These factors should be considered when trying to take preventive measures against accidents during medical examinations and treatment. en-copyright= kn-copyright= en-aut-name=OnoHiroshi en-aut-sei=Ono en-aut-mei=Hiroshi kn-aut-name=小野廣 kn-aut-sei=小野 kn-aut-mei=廣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部医学科 en-keyword=歯科診療 (dental treatment) kn-keyword=歯科診療 (dental treatment) en-keyword=偶発事故 (accident) kn-keyword=偶発事故 (accident) en-keyword=質問紙調査 (questionnaires) kn-keyword=質問紙調査 (questionnaires) END start-ver=1.4 cd-journal=joma no-vol=30 cd-vols= no-issue=2 article-no= start-page=143 end-page=161 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19980910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (Ⅸ) kn-title=マルクス主義理論史研究の課題（Ⅸ）―ウォーラーステイン『アフター・リベラリズム』によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=1 article-no= start-page=147 end-page=156 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Rosa Luxemburg and Sakae Osugi -Two Attitudes towards "Bolshevik Revolution"- en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=2 article-no= start-page=53 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On The Histry of Marxist Thoeries (X) kn-title=マルクス主義理論史研究の課題（Ⅹ）―岡田和彦著『レーニンの市場と計画の理論』によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=2 article-no= start-page=173 end-page=196 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Staat und Nation (1) kn-title=カール・レンナー「国家と民族」（上） en-subtitle= kn-subtitle= en-abstract= kn-abstract=カール・レンナー(Renner, Karl 1870～1950)は、オ－ストリア社会民主主義運動を代表する人物で、第一次世界大戦の後にオーストリア共和国初代首相を、第二次世界大戦の後には第二共和国の大統領をつとめた。オーストリア社会民主党は1899年9月に民族問題に関する有名なブリュン綱領を採択した。ブリュン大会に先立っておこなわれた民族問題に関する議論をリードした論客の代表がレンナーであった。レンナーは1899年2月9日に民族問題に関する講演をおこない、ブリュン大会の後にシノプティクス(Synopticus)という偽名で小冊子の形で出版した。ここに訳出した『国家と民族』がそれである。この著作のなかでレンナーは地域原理と個人原理を区別するオーストロ・マルクス主義に特徴的な民族理論を展開した。レンナーの民族理論は、その後オーストリアの後輩オットー・バウアーに継承されるとともに、ロシアのボリシェヴィキから厳しい非難を浴びた。レンナーの民族自治の構想はその当時には実現されなかったが、EUの先駆をなすものであったという評価もある。日本でレンナーの民族理論について検討した文献としては、須藤博忠『オーストリアの歴史と社会民主主義』（信山社、1995年（および倉田稔「レンナー」（丸山敬一編『民族問題―現代のアポリア―』ナカニシヤ出版、1997年、第三章）がある。ほかに日本語文献として、法学関係で二種類の翻訳がある。後藤清訳、カルネル（偽名）『法律制度―特に所有権の―社会的機能』(叢文閣、1928年)、加藤正男訳『私法制度の社会的機能』（法律文化社、1968年）。訳出の底本は,Synopticus, Staat und Nation: Zur österreichischen Nationalitätenfrage: Staatsrechtliche Untersuchung über die möglichen Principien einer Lösung und die juristischen Voraussetzungen eines Nationalitätengesetzes, Mit einer Literaturübersicht, Verlag von Josef Dietl Buchhandlung, Wien, 1899である｡テキストの入手については相田慎一氏にお世話になった｡記して謝意を表します｡ en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=3 article-no= start-page=93 end-page=113 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20001120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Staat und Nation" (2) kn-title=カール・レンナー「国家と民族」（下） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=1 article-no= start-page=67 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Die Nation : Mythos und Wirklichkeit" (2) kn-title=カール・レンナー『民族：神話と現実』(2) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=4 article-no= start-page=233 end-page=253 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner 'Der Werdegang der Nation' (aus "Die Nation : Mythos und Wirklichkeit") kn-title=カール・レンナー「民族の生い立ち」 en-subtitle= kn-subtitle= en-abstract= kn-abstract=オーストリア第二共和国の初代大統領カール・レンナーは，1950年に死去した。死後間もなく3巻の『遺稿集』が出版されたが，民族問題に関する遺稿『民族：神話と現実』はそこに収録されなかった。この遺構は，「偶然に本を発見」に述べられているような経緯で，1964年にジャック・ハナクによって編集され，出版された。ここに訳出した「民族の生い立ち」はこの遺構の第一論文である。1899年，『国家と民族』によって，当時ではまったく独自な民族問題把握を提示したレンナーの，最晩年の民族問題論として検討に値するものである。この論文の理解を助けるものとして，ハナクによる「偶然に本を発見」と題する解説とレンナー自身による「序言」をも訳出しておく。訳出の底本は，Karl Renner, Die Nation: Mythos und Wirklichkeit, Manuskript aus dem Nachlass, Herausgegeben von Jacques Hannak, Mit einer Einleitung von Bruno Pittermann, Europa Verlag, Wien, 1964. である。 en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=2 article-no= start-page=49 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Die Nation : Mythos und Wirklichkeit" (3) kn-title=カール・レンナー『民族：神話と現実』(3) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=3 article-no= start-page=67 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Die Nation : Mythos und Wirklichkeit" (4) kn-title=カール・レンナー『民族：神話と現実』(4) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=3 article-no= start-page=33 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (XI) kn-title=マルクス主義理論史研究の課題 (XI) ―久間清俊著『近代市民社会と高度資本主義－ドイツ社会思想史研究－』によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=4 article-no= start-page=47 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Das Selbstbestimmungsrecht der Nationen in besonderer Anwendung auf Oesterreich" (3) kn-title=カール・レンナー『諸民族の自決権』(3) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=4 article-no= start-page=35 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (XIII) kn-title=マルクス主義理論史研究の課題（XIII）―植村邦彦著『マルクスを読む』によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=4 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Recent Rosa Luxemburg Studies in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=3 article-no= start-page=143 end-page=166 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20021210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Das Selbstbestimmungsrecht der Nationen in besonderer Anwendung auf Oesterreich" (2) kn-title=カール・レンナー『諸民族の自決権』(2) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=4 article-no= start-page=67 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Die Nation : Mythos und Wirklichkeit" (5) kn-title=カール・レンナー『民族：神話と現実』(5) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=3 article-no= start-page=63 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20021210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (XII) kn-title=マルクス主義理論史研究の課題 (XII) ―相田愼一著『言語としての民族―カウツキーと民族問題―』によせて― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=2 article-no= start-page=57 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Das Selbstbestimmungsrecht der Nationen in besonderer Anwendung auf Oesterreich" (1) kn-title=カール・レンナー『諸民族の自決権』(1) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=1 article-no= start-page=107 end-page=131 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Das Selbstbestimmungsrecht der Nationen in besonderer Anwendung auf Oesterreich" (8) kn-title=カール・レンナー『諸民族の自決権』(8) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=1 article-no= start-page=17 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Translations of Otto Bauer's "Die Nationalitätenfrage und die Sozialdemokratie" kn-title=オット・バウアー『民族問題と社会民主主義』の諸翻訳をめぐって en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=4 article-no= start-page=65 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Das Selbstbestimmungsrecht der Nationenin besonderer Anwendung auf Oesterreich" (7) kn-title=カール・レンナー『諸民族の自決権』(7) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=2 article-no= start-page=87 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Das Selbstbestimmungsrecht der Nationen in besonderer Anwendung auf Oesterreich" (9) kn-title=カール・レンナー『諸民族の自決権』(9) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=3 article-no= start-page=107 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20031210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Das Selbstbestimmungsrecht der Nationen in besonderer Anwendung auf Oesterreich" (6) kn-title=カール・レンナー『諸民族の自決権』(6) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=3 article-no= start-page=91 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner"Das Selbstbestimmungsrecht der Nationen in besonderer Anwendung auf Oesterreich" (10・Ende) kn-title=カール・レンナー『諸民族の自決権』(10・完) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=3 article-no= start-page=19 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20031210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Logic of "Die Nationalitätenfrage und die Sozialdemokratie" by Otto Bauer kn-title=オットー・バウアー『民族問題と社会民主主義』の論理 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The greatest contribution in "Die Nationaltaetenfrage und die Sozialdemokratie" by Otto Bauer" is the explanation of generation and development of nation including "waking of peoples without history". The contents which should be called the renovation (or reconstruction) of the historical materialism by Bauer are developed. The logic of development of nation is making the nation essence theory in a wide sense with the nation essence theory in a narrow sense (= "definition of nation"). The conventional researches took only "definition of nation" without referece to others ,and abandande themselves to inquiry of definitions. Such attitudes should be reconsiderd. Although Bauer included the logic of national development in historical materialism,he did not necessarily succeed in adjusting it to the Marxian historical materialism centering on class struggle. Since the logic of class struggle was restraining the logic of national development from the outside in Bauer's explantaion, he could not solve an actural complicated tangle of class and nation. There is a problem in connection with the limit of Marxism which understands history centering on class struggle. By taking out the logic of national development, Bauer could show the limit of Marxism clearlier than anyone. In spite of including personal national autonomy policy which Karl Renner proposed, Bauer's national policy is ecletic and also includes the territorial national autonomy policy of "Brünner Programm". In grounding the personal national autonomy policy Bauer also followed Renner, and his originality is not found. Bauer's ecletic position corresponds to the disregard to Renner's view of law and state. Such theoretical background of Bauer has relevance to his prompt abandonce of personal national autonomy policy during the World War. We cannot ask for theoretical grounding of a personal national autonomy policy in Bauer. It will be necessary to reconsider Austrian national theory in a broader perspective. en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=2 article-no= start-page=53 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Das Selbstbestimmungsrecht der Nationen in besonderer Anwendung auf Oesterreich" (5) kn-title=カール・レンナー『諸民族の自決権』(5) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1 article-no= start-page=35 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Karl Renner "Das Selbstbestimmungsrecht der Nationen in besonderer Anwendung auf Oesterreich" (4) kn-title=カール・レンナー『諸民族の自決権』(4) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=4 article-no= start-page=37 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Rudolf Springer [Karl Renner] “Der Kampf der Oesterreichischen Nationen um den Staat” Erster Theil : Das nationale Problem als Verfassungs= und Verwaltungsfrage. (2) kn-title=ルドルフ・シュプリンガー［カール・レンナー］『国家をめぐるオーストリア諸民族の闘争』第一部：憲法・行政問題としての民族的問題(2) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=3 article-no= start-page=107 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Rudolf Springer [Karl Renner] “Der Kampf der Oesterreichischen Nationen um den Staat” Erster Theil : Das nationale Problem als Verfassungs= und Verwaltungsfrage. (1) kn-title=ルドルフ・シュプリンガー［カール・レンナー］『国家をめぐるオーストリア諸民族の闘争』第一部：憲法・行政問題としての民族的問題(1) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=1 article-no= start-page=89 end-page=102 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the History of Marxist Theories (XIV) kn-title=マルクス主義理論史研究の課題 (XIV) ―マルクス，修正主義論争，ボリシェヴィズム― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtaYoshiki en-aut-sei=Ota en-aut-mei=Yoshiki kn-aut-name=太田仁樹 kn-aut-sei=太田 kn-aut-mei=仁樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END