検索結果 15717 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Wang, Tianyi| Gao, Tong| Fujisawa, Masayoshi| Ohara, Toshiaki| Sakaguchi, Masakiyo| Yoshimura, Teizo| Matsukawa, Akihiro| |
| キーワード | autophagy mitophagy SPRED proteins MAPK/ERK mTOR hepatocellular carcinoma |
| 発行日 | 2024-06-06 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 25巻 |
| 号 | 11号 |
| 出版者 | MDPI |
| 開始ページ | 6269 |
| ISSN | 1661-6596 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©2024 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/ijms25116269 |
| Web of Science KeyUT | 001245555700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms25116269 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Akiba, Kazuto| Akahama, Yuichi| Tokunaga, Masashi| Kobayashi, Tatsuo C.| |
| 発行日 | 2024-05-03 |
| 出版物タイトル | Physical Review B |
| 巻 | 109巻 |
| 号 | 20号 |
| 出版者 | American Physical Society (APS) |
| 開始ページ | L201103 |
| ISSN | 2469-9950 |
| NCID | AA11187113 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©2024 American Physical Society |
| 論文のバージョン | publisher |
| DOI | 10.1103/physrevb.109.l201103 |
| Web of Science KeyUT | 001238896400003 |
| 関連URL | isVersionOf https://doi.org/10.1103/physrevb.109.l201103 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Li, Yuying| Wang, Qiong| Jia, Huimin| Ishikawa, Kazuya| Kosami, Ken-Ichi| Ueba, Takahiro| Tsujimoto, Atsumi| Yamanaka, Miki| Yabumoto, Yasuyuki| Miki, Daisuke| Sasaki, Eriko| Fukao, Yoichiro| Fujiwara, Masayuki| Kaneko-Kawano, Takako| Tan, Li| Kojima, Chojiro| Wing, Rod A.| Sebastian, Alfino| Nishimura, Hideki| Fukada, Fumi| Niu, Qingfeng| Shimizu, Motoki| Yoshida, Kentaro| Terauchi, Ryohei| Shimamoto, Ko| Kawano, Yoji| |
| 備考 | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48943-5| |
| 発行日 | 2024-05-30 |
| 出版物タイトル | Nature Communications |
| 巻 | 15巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 4610 |
| ISSN | 2041-1723 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38816417 |
| DOI | 10.1038/s41467-024-48943-5 |
| Web of Science KeyUT | 001236316700012 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41467-024-48943-5 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nakamoto, Shogo| Shien, Tadahiko| Iwamoto, Takayuki| Kubo, Shinichiro| Yamamoto, Mari| Yamashita, Tetsumasa| Kuwahara, Chihiro| Ikeda, Masahiko| |
| 発行日 | 2024-04-30 |
| 出版物タイトル | Scientific Reports |
| 巻 | 14巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 9869 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38684839 |
| DOI | 10.1038/s41598-024-60101-x |
| Web of Science KeyUT | 001211286800006 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-024-60101-x |
| JaLCDOI | 10.18926/AMO/67207 |
|---|---|
| フルテキストURL | 78_3_301.pdf |
| 著者 | Nakazaki, Kiyoshi| Hirai, Satoshi| Hishikawa, Tomohito| |
| 抄録 | We report a case of a large vestibular schwannoma in an 80-year-old female patient that shrank after palliative Gamma Knife radiosurgery (GKS). Neurological symptoms included hearing deterioration and facial palsy. The tumor volume was 21.9 mL. Craniotomy was considered high-risk, and conventional GKS was risky, owing to the risk of transient enlargement. Therefore, GKS was performed on only a portion of the tumor. The marginal dose (12 Gy) volume was 3.8 mL (17.4%). The tumor began to shrink after transient enlargement. Sixty months later, the tumor volume was only 3.1 mL, and the patient was able to maintain independent activities of daily living without salvage treatment. |
| キーワード | vestibular schwannoma Gamma Knife radiosurgery large volume palliative elderly patient |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 301 |
| 終了ページ | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902220 |
| Web of Science KeyUT | 001267340600001 |
| JaLCDOI | 10.18926/AMO/67206 |
|---|---|
| フルテキストURL | 78_3_295.pdf |
| 著者 | Okamoto, Sara| Shiode, Yusuke| Kimura, Shuhei| Hosokawa, Mio| Matoba, Ryo| Kanzaki, Yuki| Kindo, Hiroya| Morita, Tetsuro| Tsuji, Akihiro| Takahashi, Kosuke| Morizane, Yuki| |
| 抄録 | A Japanese woman in her 70s was referred to our hospital for the evaluation and treatment of high intraocular pressure (IOP) in her right eye. She had undergone bilateral cataract surgeries and the insertion of hydrophilic acrylic intraocular lenses (IOLs). We performed trabeculotomy and trabeculectomy to lower her right IOP; thereafter, a circular opacity was observed on the right eye’s IOL surface. We removed the right IOL because that eye’s vision had decreased due to IOL opacification. The analysis of the removed IOL revealed that the main opacity component was calcium phosphate. This is the first post-glaucoma-surgery IOL calcification case report. |
| キーワード | intraocular lens IOL IOL calcification hydrophilic acrylic IOL glaucoma surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 295 |
| 終了ページ | 300 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902219 |
| Web of Science KeyUT | 001267339400001 |
| JaLCDOI | 10.18926/AMO/67205 |
|---|---|
| フルテキストURL | 78_3_291.pdf |
| 著者 | Minagi, Hitoshi| Aoki, Hideki| Doita, Susumu| Miyake, Eiki| Ogawa, Toshihiro| Taniguchi, Fumitaka| Watanabe, Megumi| Arata, Takashi| Katsuda, Koh| Tanakaya, Kohji| |
| 抄録 | In the clinical course of malignant melanoma, which can metastasize to multiple organs, gallbladder metastases are rarely detected. A 69-year-old man who underwent resection of a primary malignant melanoma was subsequently treated with nivolumab for lung metastases and achieved complete response. Seven years after surgery, multiple nodules were found in the gallbladder, and he underwent laparoscopic cholecystectomy. The postoperative diagnosis was metastases of malignant melanoma. He has been recurrence-free 8 months after surgery. If radical resection is possible, such surgery should be performed for gallbladder metastases found in patients with other controlled lesions of malignant melanoma. |
| キーワード | malignant melanoma gallbladder metastasis laparoscopic cholecystectomy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 291 |
| 終了ページ | 294 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902218 |
| Web of Science KeyUT | 001267351900003 |
| JaLCDOI | 10.18926/AMO/67204 |
|---|---|
| フルテキストURL | 78_3_285.pdf |
| 著者 | Hirano, Shuichiro| Otani, Yoshihiro| Fujii, Kentaro| Date, Isao| |
| 抄録 | Organized chronic subdural hematoma (OCSDH) is a relatively rare condition that forms over a longer period of time compared to chronic subdural hematoma and is sometimes difficult to diagnose with preoperative imaging. We resected an intracranial lesion in a 37-year-old Japanese man; the lesion had been increasing in size for >17 years. The preoperative diagnosis based on imaging findings was meningioma; however, pathological findings revealed OCSDH. Clinicians should be aware that OCSDH mimics other tumors and consider surgical strategies for this disease. |
| キーワード | meningioma organized chronic subdural hematoma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 285 |
| 終了ページ | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902217 |
| Web of Science KeyUT | 001267351900002 |
| JaLCDOI | 10.18926/AMO/67203 |
|---|---|
| フルテキストURL | 78_3_281.pdf |
| 著者 | Okada, Kazuhiro| Maki, Yuho| Matsubara, Kei| Hirano, Yutaka| Fujiwara, Toshiya| Matsuura, Motoki| |
| 抄録 | A 24-year-old Japanese female with anorexia nervosa presented to our hospital for bilateral pneumothorax, and 12-Fr thoracostomy catheters were inserted into the bilateral pleural cavities. On hospital day 9, a thoracoscopic bullectomy was performed. However, air leakage relapsed on both sides on postoperative day 1. The air leakage on the right side was particularly persistent, and we switched the drainage to a Heimlich valve. Both lungs expanded gradually and the chest tube was removed on postoperative day 19. Passive pleural drainage might be an option for prolonged air leakage after a bullectomy in patients with anorexia nervosa. |
| キーワード | spontaneous pneumothorax anorexia nervosa Heimlich valve |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 281 |
| 終了ページ | 284 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902216 |
| Web of Science KeyUT | 001267351900001 |
| JaLCDOI | 10.18926/AMO/67202 |
|---|---|
| フルテキストURL | 78_3_271.pdf |
| 著者 | Ye, Mengjiao| Zhang, Renwei| |
| 抄録 | We investigated how humidified high-flow nasal cannula oxygen therapy (HFNC) with a pulmonary infection control (PIC) window as a ventilation switching indication in combination with atomizing inhalation of terbutaline affects the lung function of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We examined 140 hospitalized AECOPD patients randomized to control and observation groups. Conventional supportive therapy and invasive mechanical ventilation with tracheal intubation were conducted in both groups, with a PIC window as the indication for ventilation switching. Noninvasive positive pressure ventilation (NIPPV) plus atomizing inhalation of terbutaline was used in the control group. In the observation group, HFNC combined with atomizing inhalation of terbutaline was used. Compared to the control group, after 48-hr treatment and treatment completion, the observation group had significantly increased levels of lung function indicators (maximal voluntary ventilation [MVV] plus forced vital capacity [FVC], p<0.05) and oxygen metabolism indicators (arterial oxygen partial pressure [PaO2], arterial oxygen content [CaO2], and oxygenation index, p<0.05). The comparison of the groups revealed that the levels of airway remodeling indicators (matrix metalloproteinase-2 [MMP-2], tissue inhibitor of metalloproteinase 2 [TIMP-2] plus MMP-9) and inflammatory indicators (interferon gamma [IFN-γ] together with interleukin-17 [IL-17], IL-10 and IL-4) were significantly lower after 48 h of treatment as well as after treatment completion (both p<0.05). These results demonstrate that HFNC with a PIC window as the indication for ventilation switching combined with atomizing inhalation of terbutaline can relieve the disorder of oxygen metabolism and correct airway hyper-reactivity. |
| キーワード | chronic obstructive pulmonary disease inhalation oxygen therapy pulmonary function ventilation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 271 |
| 終了ページ | 279 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902215 |
| Web of Science KeyUT | 001267351000008 |
| JaLCDOI | 10.18926/AMO/67201 |
|---|---|
| フルテキストURL | 78_3_259.pdf |
| 著者 | Vural, Gonul| Demir, Esra| Gumusyayla, Sadiye| Eren, Funda| Barakli, Serdar| Neselioglu, Salim| Erel, Ozcan| |
| 抄録 | The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured. We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients. |
| キーワード | multiple sclerosis dysfunctional HDL thiol–disulfide homeostasis cognitive decline |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 259 |
| 終了ページ | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902214 |
| Web of Science KeyUT | 001267351000007 |
| JaLCDOI | 10.18926/AMO/67200 |
|---|---|
| フルテキストURL | 78_3_251.pdf |
| 著者 | Murofushi, Koji| Mitomo, Sho| Hirohata, Kenji| Furuya, Hidetaka| Katagiri, Hiroki| Kaneoka, Koji| Yagishita, Kazuyoshi| |
| 抄録 | There have been few investigations into the effectiveness of thoracic spine exercises for improving thoracic range of motion (ROM) in any plane. This study assessed the effectiveness of two thoracic spine exercises: one in the quadruped position and one in the thoracic standing position. We determined how these exercises affect thoracic spine mobility ROM over a 2-week intervention period. Thirty-nine healthy participants were enrolled and assigned to a Quadruped Thoracic Rotation group (n=17 participants: 9 females and 8 males) or Flamenco Thoracic Spine Rotation group (n=22: 14 females and 8 males). All participants were administered a KOJI AWARENESSTM screening test, and the initial thoracic spine ROM before intervention exercise was measured in a laboratory setting. Quadruped Thoracic Rotation was performed as the quadruped exercise and Flamenco Thoracic Spine Rotation as the standing exercise. The KOJI AWARENESSTM thoracic spine test and ROM were evaluated on the day after the first exercise session and again after the program. Despite their different approaches to thoracic mobility, the quadruped exercise and standing exercise achieved equivalent improvement in thoracic ROM after 2 weeks. Practitioners have a range of exercise options for enhancing thoracic mobility based on their environmental or task-specific needs. |
| キーワード | thoracic spine thoracic rotation range of motion exercise intervention |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 251 |
| 終了ページ | 258 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902213 |
| Web of Science KeyUT | 001267351000006 |
| JaLCDOI | 10.18926/AMO/67199 |
|---|---|
| フルテキストURL | 78_3_245.pdf |
| 著者 | Akagawa, Manabu| Saito, Hidetomo| Takahashi, Yasuhiro| Iwamoto, Yosuke| Iida, Junpei| Yoshikawa, Takayuki| Abe, Toshiki| Saito, Kimio| Kijima, Hiroaki| Kasukawa, Yuji| Hongo, Michio| Miyakoshi, Naohisa| |
| 抄録 | Although several studies have suggested a possible association between sarcopenia and knee osteoarthritis (OA) in the elderly, there remains no definitive evidence. Recently, however, the serum creatinine/cystatin C ratio (sarcopenia index: SI) was reported to correlate with skeletal muscle mass. The present retrospective study therefore investigated the impact of reduced skeletal muscle mass on advanced knee OA using SI. In 55 individuals scheduled for knee osteotomy or knee arthroplasty, correlations between SI and patient-reported outcomes such as the Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS) were explored. Significant associations were found between SI and the KSS functional activity score (β=0.37; p=0.022), KOOS subscale for activities of daily living (β=0.42; p=0.0096), and OKS (β=0.42; p=0.0095). This study underscores the role of reduced muscle mass in functional outcomes and introduces SI as a valuable marker for assessing muscle loss in knee OA patients. |
| キーワード | knee osteoarthritis sarcopenia index reduced muscle mass activities of daily living functional activity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 245 |
| 終了ページ | 250 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902212 |
| Web of Science KeyUT | 001267351000005 |
| JaLCDOI | 10.18926/AMO/67198 |
|---|---|
| フルテキストURL | 78_3_237.pdf |
| 著者 | Muraoka, Osamu| Imai, Norio| Kuraishi, Tatsuya| Imai, Makoto| Fukuhara, Takashi| Yoshimine, Toshifumi| |
| 抄録 | Fracture liaison services (FLS) have been introduced in Japan and several other countries to reduce medical complications and secondary fractures. We aimed to evaluate the effects of the implementation of an FLS approach on patient outcomes during hospitalization at our hospital and over a 2-year follow-up post-injury. This retrospective cohort study included patients ≥ 60 years admitted to our hospital for hip fragility fractures between October 1, 2016, and July 31, 2020. Patient groups were defined as those treated before (control group, n=238) and after (FLS group, n=196) establishment of the FLS protocol at our institution. The two groups were compared in terms of time to surgery, length of hospital stay, and the incidence of complications after admission, including secondary hip fracture and mortality rates. The follow-up period was 24 months. FLS focuses on early surgery within 48 h of injury and assessing osteoporosis treatment before injury to guide post-discharge anti-osteoporosis medication. FLS reduced the length of hospital stay (p<0.001) and the prevalence of complications after admission (p<0.001), particularly cardiovascular disease, and it increased adherence to anti-osteoporosis medication. These FLS effects resulted in lower secondary hip fracture and mortality rates at 12 and 24 months post-injury. FLS for fragility hip fractures can improve patient outcomes during hospitalization and over a 2-year follow-up period. |
| キーワード | fracture liaison services complications after admission secondary hip fracture mortality |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 237 |
| 終了ページ | 243 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902211 |
| Web of Science KeyUT | 001267351000004 |
| JaLCDOI | 10.18926/AMO/67197 |
|---|---|
| フルテキストURL | 78_3_227.pdf |
| 著者 | Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
| 抄録 | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. |
| キーワード | lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 227 |
| 終了ページ | 235 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902210 |
| Web of Science KeyUT | 001267351000003 |
| JaLCDOI | 10.18926/AMO/67196 |
|---|---|
| フルテキストURL | 78_3_215.pdf |
| 著者 | Akagawa, Takuya| Fukui, Ryohei| Kida, Katsuhiro| Matsuura, Ryutaro| Shimada, Makoto| Kinoshita, Mitsuhiro| Akagawa, Yoko| Goto, Sachiko| |
| 抄録 | We propose a sitting position that achieves both high image quality and a reduced radiation dose in elbow joint imaging by area detector computed tomography (ADCT), and we compared it with the ‘superman’ and supine positions. The volumetric CT dose index (CTDIvol) for the sitting, superman, and supine positions were 2.7, 8.0, and 20.0 mGy and the dose length products (DLPs) were 43.4, 204.7, and 584.8 mGy • cm, respectively. In the task-based transfer function (TTF), the highest value was obtained for the sitting position in both bone and soft tissue images. The noise power spectrum (NPS) of bone images showed that the superman position had the lowest value up to approx. 1.1 cycles/mm or lower, whereas the sitting position had the lowest value when the NPS was greater than approx. 1.1 cycles/mm. The overall image quality in an observer study resulted in the following median Likert scores for Readers 1 and 2: 5.0 and 5.0 for the sitting position, 4.0 and 3.5 for the superman position, and 4.0 and 2.0 for the supine position. These results indicate that our proposed sitting position with ADCT of the elbow joint can provide superior image quality and allow lower radiation doses compared to the superman and supine positions. |
| キーワード | area detector computed tomography elbow joint sitting position dose reduction image quality assessment |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 215 |
| 終了ページ | 225 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902209 |
| Web of Science KeyUT | 001267351000002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Swe, Hnin‐Wint‐Wint| Fujisawa, Masayoshi| Ohara, Toshiaki| Komatsubara, Yu| Yoshimura, Teizo| Shien, Tadahiko| Matsukawa, Akihiro| |
| キーワード | angiogenesis blood vessels breast cancer CD31 antigen immunohistochemistry microvessel density survival analysis |
| 発行日 | 2024-05-31 |
| 出版物タイトル | Pathology International |
| 巻 | 74巻 |
| 号 | 7号 |
| 出版者 | Wiley |
| 開始ページ | 394 |
| 終了ページ | 407 |
| ISSN | 1320-5463 |
| NCID | AA10984364 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 38818885 |
| DOI | 10.1111/pin.13442 |
| Web of Science KeyUT | 001235649700001 |
| 関連URL | isVersionOf https://doi.org/10.1111/pin.13442 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takamura, Hiroyoshi| Sugitani, Yuki| Morishita, Ryohei| Yorisue, Takefumi| Kadota, Isao| |
| 発行日 | 2024 |
| 出版物タイトル | Organic & Biomolecular Chemistry |
| 巻 | 22巻 |
| 号 | 28号 |
| 出版者 | Royal Society of Chemistry (RSC) |
| 開始ページ | 5739 |
| 終了ページ | 5747 |
| ISSN | 1477-0520 |
| NCID | AA1168650X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Royal Society of Chemistry 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38828517 |
| DOI | 10.1039/d4ob00698d |
| Web of Science KeyUT | 001237473000001 |
| 関連URL | isVersionOf https://doi.org/10.1039/d4ob00698d |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ueno, Asami| Onishi, Yasuhiro| Mise, Koki| Yamaguchi, Satoshi| Kanno, Ayaka| Nojima, Ichiro| Higuchi, Chigusa| Uchida, Haruhito A.| Shikata, Kenichi| Miyamoto, Satoshi| Nakatsuka, Atsuko| Eguchi, Jun| Hida, Kazuyuki| Katayama, Akihiro| Watanabe, Mayu| Nakato, Tatsuaki| Tone, Atsuhito| Teshigawara, Sanae| Matsuoka, Takashi| Kamei, Shinji| Murakami, Kazutoshi| Shimizu, Ikki| Miyashita, Katsuhito| Ando, Shinichiro| Nunoue, Tomokazu| Wada, Jun| |
| 発行日 | 2024-05 |
| 出版物タイトル | BMJ Open Diabetes Research and Care |
| 巻 | 12巻 |
| 号 | 3号 |
| 出版者 | BMJ Publishing Group |
| 開始ページ | e004237 |
| ISSN | 2052-4897 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Author(s) (or their employer(s)) 2024. |
| 論文のバージョン | publisher |
| PubMed ID | 38816205 |
| DOI | 10.1136/bmjdrc-2024-004237 |
| Web of Science KeyUT | 001236385500001 |
| 関連URL | isVersionOf https://doi.org/10.1136/bmjdrc-2024-004237 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Vo, Quan Duy| Saito, Yukihiro| Ida, Toshihiro| Nakamura, Kazufumi| Yuasa, Shinsuke| |
| 発行日 | 2024-05-21 |
| 出版物タイトル | PLoS ONE |
| 巻 | 19巻 |
| 号 | 5号 |
| 出版者 | Public Library of Science |
| 開始ページ | e0302537 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Vo et al. |
| 論文のバージョン | publisher |
| PubMed ID | 38771829 |
| DOI | 10.1371/journal.pone.0302537 |
| Web of Science KeyUT | 001228816000059 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0302537 |