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JaLCDOI 10.18926/21215
タイトル(別表記) Studies on lithium in the field of balneology : Effects of lithium salts on analgesic activity of aminopyrine
フルテキストURL pitsr_045_025_031.pdf
著者 古野 勝志| 御船 政明|
抄録 The authors studied the effect of pretreatment with internal use of lithium salts on analgesic activity of aminopyrine by hot-plate test in mice. The male mice at 4 weeks of age weighting 17-19 g were divided into 7 groups. Earch group being composed of 9-10 mice was given oraBy 0.1 ml of LiCI-solution per 10 g of body weight for 35 days, LiCl was dissolved in 0.9% saline solution, in such concentrations that each group received 0 mg, 50 mg, 100mg, 200 mg and 400mg of LiCl for each kg of body weight of mouse, respectively, Control group received only 0.9% saline solution. On the 1st, 3rd, 7th, 14th, 21st, 28th and 35th days of this experiment, 0.1 ml of 1% solution of aminopyrine per 109 of body weight was injected intraperitoneaJly and then tested 30 minutes later. In the hot-plate test, a mouse is placed on a hot plate being adjusted with the thermostat at 55°±1℃, and the response is licking or lifting the hind feet or an outright attempt to escape from the plate, The increase in response time is used to quantify the analgesic effect of aminopyrine, The results were as follows : 1. The response time in groups receiving 0-50 mg of LiCl per kg of body weight had decreased on the 14 th day, but it tended to return to the initial level after the 21st day of experiment. 2. The response time in groups receiving 100-400 mg of LiCl per kg of body weight had also decreased on the 14 th day, and the degree of the decrease in response time was greater than that of the former and then remained faily constant at this level to the end of the observation period. These results would indicate that LiCl inhibits the analgesic activity of aminopyrine.
出版物タイトル 岡山大学温泉研究所報告
発行日 1976-03-25
45巻
開始ページ 25
終了ページ 31
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002311002
JaLCDOI 10.18926/21202
タイトル(別表記) Circulatory changes in rheumatoid fingers as estimated by thermography and photoelectric plethysmography
フルテキストURL pitser_046_015_023.pdf
著者 太田 隆正| 時岡 正明| 高杉 潔|
抄録 In an attempt to evaluate circulatory changes in patients with rheumatoid arthritis (RA), 20 patients with classical or definite RA as determined by ARA criteria and twenty healthy volunteers serving as control were randomly selected. None of the patients showed the clinical signs suggesting Raynaud's phenomenon. Thermograms as well as photoelectric plethysmograms were obtained solely from the right middle finger tip of each examinee. The whole hand was then immersed in the cold (10℃) water and kept there for one minute. After wiping away the wet hand with a dry towel very gently, we followed the sequential changes of the tempe· rature of the third finger tip and the period of time necessary for the tip to return to the original temperature prior to the cold water immersion was measured and expressed as 'return time' in minute. Before exposure to the cold, the mean values of temperature of the finger tips between the two groups were not significantly different. As opposed to the normal pattern in which one can find the warmest point at the finger tip and which was more frequently found in the control group of the current study, a type in which the distal part of the finger was much cooler than the proximal area (so-called 'distal cold type') was observed in 8 RA patients, whereas only four demonstrated this pattern in the control group. After brief exposure to the cold, eight out of 20 rheumatoid patients showed much prolonged return time (longer than 20 minutes), while only three of 20 controls remained with prolonged cool periphery, The difference between the two, however, was not statistically significant. Studies of the digital plethysmograph revealed that 70% of all the rheumatoids showed abnormal patterns: sclerotic and monophasic waves were discovered in 55% of the patients. In contrast, seventy percent of the normal control demonstra· ted normal wave pattern. Although the significant difference was not noted, the mean height of the systolic peak of the plethysmograph derived from the rheumatoid group tended to be much reduced, suggesting the reduced blood volume at the finger tips. Six RA patients and 13 normals who showed normal plethysmographic pattern before immersion in the cold water, demonstrated rapid return to the original temperature. Only in one normal control with a normal wave pattern, prolonged return time was observed, although the height of the systolic peak of the plethysmogram in this particular case was well within normal limit. Digital circulatory disturbance, however, was strongly suspected in eight RA patients with severely prolonged return time, They all showed abnormal wave patterns of the plethysmogram, including 2 cases with peripheral plateau wave, Markedly reduced heights of the systolic peaks were also demonstrated in all. Further elaborate studies including digital arteriography were indicated to implicate any organic change in the digital vessels, such as digital arteritis in RA first reported by Bywaters in 1957.
出版物タイトル 岡山大学温泉研究所報告
発行日 1977-03-25
46巻
開始ページ 15
終了ページ 23
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310966
JaLCDOI 10.18926/21194
タイトル(別表記) Stable isotope study of the hotsprings and volcanoes of Hokkaido, Japan
フルテキストURL pitsr_047_055_067.pdf
著者 松葉谷 治| 酒井 均| 上田 晃| 堤 真| 日下部 実| 佐々木 昭|
抄録 Stable isotope ratios of hydrogen, oxygen, carbon and sulfur of precipitation, thermal and mineral waters, and volcanic gases were measured. The isotopic data combined with chemical and geological information were discussed in terms of origin and evolution of the hotsprings and volcanic gases. The hotsprings along the Uchiura Bay, Oshima Peninsula are mostly near-neutral NaCl-type thermal water and may be divided into three groups : (1) thermal waters isotopically similar to the precipitation of this area, (2) those similar in D/H to the local meteoric waters but enriched by 2 to 3‰ in (18)O compared to the latter, and (3) those enriched significantly in both D and (18)O relative to the local meteoric waters. The first and second types of thermal water probably form from local meteoric water which percolates through "Green Tuff" formations and acquires dissolved chemicals from them. However, high salt concentration and the oxygen isotope shift (thesecond type) may imply that the NaCl-type water of volcanic origin might be involved. On the other hand, the waters of the third group can be explained by mixing of modern sea water into the second type thermal water (in case of Yachigashira) or by incorporation of fossil sea water of Tertiary origin into modern meteoric water (Nigorigawa). Except for Esan, Noboribetsu and Atosanupuri volcanic systems, waters from all the hotsprings and volcanic fumaroles associated with Quaternary volcanic rocks are meteoric in origin. Thermal waters at Esan, Noboribetsu and Atosanupuri have δD = -30~-50 and δ(18)O = -1~+ 3‰ and are enriched in D and (18)O relative to local meteoric water of the respective area. The origin of these waters and the mechanism (s) controlling the isotope ratios could not be made clear by the present study. Interesting is the finding that at Esan, Noboribetsu and Atosanupuri, thermal waters are enriched in D and (18)O relative to near-by fumarolic gases. The enrichment factor is 18 to 26‰ for hydrogen and 4 to 6‰ for oxygen, implying that more than one stages of liquidvapor separation are taking place in underground hydrothermal systems.
出版物タイトル 岡山大学温泉研究所報告
発行日 1978-03-25
47巻
開始ページ 55
終了ページ 67
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 40000321119
JaLCDOI 10.18926/21189
タイトル(別表記) The involvement of ear and throat in rheumatoid arthritis I. Hearing in patients with rheumatoid arthritis
フルテキストURL 047_005_024.pdf
著者 小田 昤|
抄録 Since Copeman's report on patients with hearing impairment as "rheumatoid otoarthritis?" has introduced, there have been a few reports on hearing impairment in patients with rheumatoid arthritis such as Goodwill et al. and Djupesland et aI. in European countries. On the contrary in our country there is no reference in association with hearing impairment of rheumatoid arthritis in rheumatic or otological literatures. An audiometric survey was carried out in 76 patients admitted in the Misasa branch hospital of Okayama university school of medicine on the classical or definite rheumatoid arthritis. Patients were excluded from the series if they had scarred or perforated tympanic membrane and history of otorrhea. Thus 67 patients have come to study. As control group, 15 healthy persons in hearing for each ten years, 15-24, 25-34, 35-44, 45-54, 55-64, and over 60 years, were selected and as a physiological hearing limit, rejection limit of hearingloss in dB. was made. Among 67 patients, 111 ears had hearingloss within the above mentioned rejection limit. In 23 ears, hearingloss in dB. were partial or as a whole out of the limit. They have all air-bone-conduction gap. After inflation of Eustachien tube, in most of them air conduction ability showed nearly the same level of bone conduction. In three cases even by inflation, airconduction level did not move. In one case the left side had effusion liquid and its RAreaction was positive. TwO of the former patients and the one whose effusion liquid had positive RA-test followed up for about 3 years. In the former two cases, hearing impairment got worse little by little and recovery by inflation was not seen. On both cases Gelle's test was positive. In the latter hearing impairment slowly got worse. This had lasted for about two months and had recoverd. In the se four cases heairng impairment was probably related to the rheumatoid arthritis and no other causes could be found.
出版物タイトル 岡山大学温泉研究所報告
発行日 1978-03-25
47巻
開始ページ 5
終了ページ 24
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002311022
著者 井上 妙子| 森永 寛|
発行日 1979-03-25
出版物タイトル 岡山大学温泉研究所報告
48巻
資料タイプ データ・データベース
JaLCDOI 10.18926/21158
タイトル(別表記) Experimental study of sulfur isotope exchange between S0(4)(2-) and H(2)S (aqueous) at 400℃ and 1000 bars water pressure
フルテキストURL pitsr_050_001_015.pdf
著者 鎌田 恵美| 酒井 均| 木島 宣明|
抄録 Experimental procedures used in this study are the same as those developed by Sakai and Dickson (1978). 0.005 M Na(2)S(2)O(3) solutions were heated to 400℃ under 1000 bar water pressure in a gold bag of Dickson gold-bag equipment (Fig. 1). At an elevated temperature Na(2)S(2)O(3) quickly and completely decomposed into 1:1 mixture of SO(4)(2-) and H(2)S (eq. (1)) and subsequent isotope exchange (eq. (2)) was monitored by consecutively withdrawing aliquots of solution for chemical and isotopic analyses at desired time intervals. For the preparation of SO(2) for isotope analyses, 2 to 5 mg BaSO(4) was thoroughly mixed with silica glass powder of 10 times the BaSO(4) in weight and heated to 1400℃ or so in sealed, evacuated silica glass tubings (see Fig. 2 and equation (4)). The technique is a modification of Holt and Engelkemeir (1971). The (18)O/(16)O ratios of SO(2) thus formed stayed constant by exchange with silica glass powder (Fig. 3). Numerical data of the three runs performed in this study are summarized in Tables 1 to 3. In runs 2 and 3, a small aliquot of (34)S- enriched H(2)SO(4) was added into the starting solution and thus equilibrium was approached from above the quilibrium value (see Fig. 4). When isotope exchange occurs between two molecules, X and Y, the reaction rate, r, is related to the extent of exchange, F, at given time, t, by equation (17), where X and Y indicate concentrations of given species, α(e), α(o) and α denote the fractionation factor at equilibrium, at time t=0 and at an arbitrary time t, and F = (α - α(o))/(α(e) - α(0)) or the extent of isotope exchange. Assuming the exchange rate is of the first order with respect to both X and Y and to the β'th power of hydrogen ion activity, a(H)(+), eq. (17) reduces to eq. (19), where k(1) denotes the rate constant. If X, Y and pH of solution stayed constant during the run, the half-time, t(1/2), of the exchange reaction can be obtained graphically as shown in Fig. 5. The t(1/2) for runs 1, 2, and 3 are determined to be 5.8, 5.5 and 6.1 hrs, respectively. Introducing F=0.5 and t=t(1/2) into eq. (19), we obtain eq. (20) which is graphically shown in Fig. 6 using the data by the present work and those by Sakai and Dickson(1978). The numerical values of log k(1) + 0.16 may be obtained by extrapolating the lines to pH=0 and, from these values, the rate constant, k(1) , may be calculated for temperatures of 300° and 400℃. From these two values of k(1) and from the Arrhenius plot, the activation energy of the exchange reaction was calculated to be 22 kcal/mole, a much smaller value than 55 kcal/mole obtained by Igumnov (1977). The value of β is found to be 0.29 at 300℃ and 0.075 at 400℃, although the physico-chemical nature of β is not clear to the present authors. Using these values, eq. (24), where C is a constant, is derived which would enable us to calculate the t(1/2) of any system of known ΣS and pH. However, as we do not know yet how β varies with different systems, eq. (24) is applicable only to limited systems in which temperature, total sulfur contents and pH are similar to those of the present study. Fig. 7 illustrates how t(1/2) varies with pH and total sulfur content at 300° and 400℃ and predicts t(1/2) for some solutions obtainable by hydrothermal reactions of seawater with various igneous rocks. The average equilibrium fractionation factor at 400℃ obtained by this study is 1.0153, in good accord with 1.0151 given by Igumnov et al. (1977). Theoretical fractionation factors between SO(4)(2-) and H(2)S have been calculated by Sakai (1968) , who gives too high values compared to the experimental data obtained by this and other researchers (Fig. 9). In the present study, the reduced partition function ratio (R.P.F.R.) of SO(4)(2-) was recalculated using two sets of the vibrational frequencies of SO(4)(2-) (shown in Table 5) and the valence force fields of Heath and Linnett (1947), which reproduces the observed frequencies of SO(4)(2-) better than Urey-Bradley force field used by Sakai (1968). The results of new calculation are shown in Table 6. This table also includes the R.P.F.R. of H(2)S which was calculated by Thode et al. (1971). Using these new R.P.F.R. of SO(4)(2-) and H(2)S, the fractionation factors between SO(4)(2-) and H(2)S were calculated and are listed in the last column of Table 6 and plotted in Fig. 9. Fig. 9 indicates that the new calculation gives values more shifted from the experimental values than before. The major sulfate ions in our solution at 300° and 400℃ exist as NaSO(4)(-) (Sakai and Dickson, 1978; see also Table 4 of this paper) and, therefore, the measured fractionation factors are those between NaSO(4)(-) and H(2)S. The discrepancy between the theory and experiments may, at least, be partially explained by this fact, although other more important reasons, which are not known to us at the moment, may also exist.
出版物タイトル 岡山大学温泉研究所報告
発行日 1980-03-25
50巻
開始ページ 1
終了ページ 15
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310990
JaLCDOI 10.18926/21136
タイトル(別表記) Attention to the Developmental Aspect Part I. Female Adolescent Cases of Anorexia Nervosa
フルテキストURL 052_033_037.pdf
著者 古元 順子|
抄録 The author reviewed 55 patients who had been treated as anorexia nervosa at the neuropsychiatric department of Okayama University Medical School and at the internal medicine department of Misasa Branch Hospital, Okayama University Medical School, for the past ten years from 1970 to 1980. The criteria for the present study was as follows; 1) absence of psychosis and no known physical illness for ematiation, 2) weight loss of at least 2096 of original body weight, 3) duration of anorexia of at least three months. 55 patients were classified into three groups according to the age of onset ; pre-puberty group. adolescent group and adult group. Analysis of two female adolescent cases was described in this report for the preliminary study. The results were as follows : 1) Onset of self-starvation coincided with competitious hyperactivity in sport and/or study. Self-starvation seemed to have psychological meaning of retaliation towards the mother of each patient, of compensatory gain in the dependancy need. and of keeping a pride in pubertal competitions including a pursuit in the slim body image. 2) There was the evidence of a disturbed female-identification which originated from the disturbed mother-child interaction. 3) Catharsis with analytically oriented psychotherapy improved gastro-intestinal disorders such as anorexia and constipation and reversed the negative BMR (basal metabolic rate) to the positive BMR. Recovery of menstrual periods was followed in an accordance with re-gain of the original body weight.
出版物タイトル 岡山大学温泉研究所報告
発行日 1982-03-25
52巻
開始ページ 33
終了ページ 37
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 40000321162
JaLCDOI 10.18926/21122
タイトル(別表記) Clinical problems of long-term steroid regimen for bronchial asthma, with reference to steroid-dependent cases
フルテキストURL pitsr_053_051_055.pdf
著者 周藤 真康| 駒越 春樹| 村嶋 誠| 岡田 千春| 谷崎 勝朗| 森永 寛| 塩田 雄太郎| 木村 郁郎|
抄録 Adverse side effects of steroid therapy were investigated in 32 asthmatic patients. Thirty-two patients were classified into three groups according to steroid therapy for the past five years; group 1 has been treated with continuous steroid therapy, group 2 with occasional steroid therapy and group 3 without steroid therapy. The results were as follows. 1. Group 1 showed a low level of serum cortisol at 8-9 a. m. The serum concentration of cortisol in patients with daily steroid regimen was lower as compared to that in patients with alternateday steroid therapy. 2. The daily profile of serum cortisol was low in the steroid dependent asthmatic patients, and little increase of serum cortisol level after the administration of prednisolone was shown in group 1. 3. Serum IgG and IgM levels were significantly low in steroid dependent asthmatic patients. 4. The level of serum potassium was low in group 1.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 51
終了ページ 55
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310967
JaLCDOI 10.18926/21109
タイトル(別表記) Properties of materials under hydrothermal conditions. I. Permeation of hydrogen through gold membrane
フルテキストURL pitsr_054_055_060.pdf
著者 木島 宣明|
抄録 Permeation rate of hydrogen through a gold cell made as a reaction vessel for a Dickson-type hydrothermal apparatus was measured at 50°intervals from 300°to 450℃ under a hydrothermal condition. The gold cell chosen for the measurement had a shape and size illustrated in Fig. 1 when it was fully expanded, and was a typical one in the meaning that it had been used several times for hydrothermal experiments (its total history may be equivalent to one month at 490℃) and that it had a body enlarged by about 8% in diameter from the original size as a result of pinhole check made by applying a gas pressure to the inside. The cell was filled with an appropriate amount of pure water, placed in a pressure vessel made of Ni-base alloy, pressurized by injecting water to the outside of the cell and kept under predetermined temperatures and pressure (=1 kbar). Meanwhile, small fractions of the waters inside and outside the cell were sampled at times and analyzed for H(2) gas-chromatographically as described in ref. (5). H(2) concentrations in the samples (CH(2)) were converted to H(2) fugacity values by using the conversion factors (Y) given in ref. (6). At each temperature, the permeation rate (k) of H(2) through the cell is evaluated by correlating the measured fH(2) values with time (t) according to eq. (2), where fo is the fH(2) in the outer water and is a constant, and fi and m are the fH(2) in and the mass of the inner water, respectively. The relevant data and results are shown in Table 1. The present data for the permeation rate φ, expressed in c㎥ H(2) at STP per 1c㎡ surface area, 1 mm wall thickness, 1 (bar)(1/2) of (fH(2))(1/2) difference and 1 hour, are plotted in Fig. 2 in relation to 1/T (K) and compared with one available data, which is a combination of reported solubility and diffusion coefficient data for hydrogen into gold at higher temperatures. The present data can be fitted into eq. (3). The present result may be of importance for hydrothermal experimental studies of geochemical redox reactions and of hydrogen isotope exchange reactions, and the technique used may also be important as a new, simple method of measuring hydrogen permeability through noble metals.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-03-25
54巻
開始ページ 55
終了ページ 60
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310991
著者 岡山大学温泉研究所|
発行日 1984-11-30
出版物タイトル 岡山大学温泉研究所報告
55巻
資料タイプ その他
著者 岡山大学温泉研究所|
発行日 1984-11-30
出版物タイトル 岡山大学温泉研究所報告
55巻
資料タイプ その他
著者 井上 妙子| 谷崎 勝朗| 森永 寛|
発行日 1984-11-30
出版物タイトル 岡山大学温泉研究所報告
55巻
資料タイプ データ・データベース
JaLCDOI 10.18926/21096
タイトル(別表記) Properties of materials under hydrothermal conditions: II. Permeability to aqueous NaCl and decomposition of poly(tetrafluoroethylene) (teflon)
フルテキストURL pitsr_055_011_014.pdf
著者 木島 宣明|
抄録 A piece of poly(tetrafluoroethylene) (PTFE) enclosing NaCI powder and having the dimensions shown in the inset in Fig. 1 was placed along with water in a deformable gold cell in a Dickson-type hydrothermal apparatus, and heated stepwise up to 410℃ under a constant pressure of 1 kbar. During the heating, small fractions of the solution in the cell were sampled and analyzed gas chromatographically for H(2), O(2), CH(4) and CO(4), and ion chromatographically for F(-) and Cl(-). No evolution of gases (H(2), CH(4), CO(2)) due to decomposition of PTFE, other than that due to decomposition of organic impurities, was observed over the temperature range of the experiment. The ion chromatographic analysis showed (Fig. 1) that : (1) Cl(-)leaching from the PTFE test piece continued even at 340℃ ; (2) F(-) leaching was small in amount and completed within the first step at 200℃ and 12 hours ; (3) F(-) formation due to partial decomposition of PTFE became measurable from 340℃, was linear with time, and was remarkably accelerated at temperatures above 400℃ ; (4) migration of the enclosed NaCl (partly hydrolyzed during the course of the experiment) did not occur even at 410℃ ; but (5) osmosis of water caused a puncture of the test piece within 2 hours after the temperature reached 410℃. The test piece recovered after the run was found to be retaining the original luster and hardness.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-11-30
55巻
開始ページ 11
終了ページ 14
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310961
JaLCDOI 10.18926/21095
タイトル(別表記) Spa therapy for patients with chronic obstructive lung disease
フルテキストURL pitsr_055_007_010.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 森永 寛| 貴谷 光| 中川 三郎| 木村 郁郎|
抄録 Histamine releasse from basophils induced by house dust and C. albicans was examined in 30 patients with bronchial asthma. House dust and C. albicans caused a significant amount of histamine release in subjects with a RAST score to corresponding allergen. A close correlation was found between house dust- and anti-IgE-induced histamine release. However, histamine release induced by C. albicans was considerably different from the release induced by anti-IgE.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-11-30
55巻
開始ページ 7
終了ページ 10
ISSN 0369-7142
言語 英語
論文のバージョン publisher
NAID 120002310939
JaLCDOI 10.18926/21094
タイトル(別表記) Spa therapy for patients with chronic obstructive lung disease
フルテキストURL pitsr_055_001_006.pdf
著者 谷崎 勝朗| 駒越 春樹| 周藤 真康| 中郷 実雄| 森永 寛| 大谷 純| 木村 郁郎|
抄録 Thirty-six patients with chronic obstructive lung disease (34 cases with bronchial asthma, one case with chronic bronchiolitis and one case with pulmonary emphysema) have received spa therapy. Clinical effects of sa therapy on patients with bronchial asthma depended on patient age and asthma types classified by allergic reactions and clinical symptoms. Spa therapy was effective in the cases with ages more than 31 years and the cases with non-atopic type of bronchial asthma. Regarding asthma type classified by clinical symptoms, spa therapy was more effective in the cases with bronchiolar obstructive type and the cases with bronchospasm + hypersecretion type than in the cases with bronchospasm type of bronchial asthma.
出版物タイトル 岡山大学温泉研究所報告
発行日 1984-11-30
55巻
開始ページ 1
終了ページ 6
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002311032
著者 岡山大学温泉研究所|
発行日 1984-11-30
出版物タイトル 岡山大学温泉研究所報告
55巻
資料タイプ その他
著者 岡山大学温泉研究所|
発行日 1984-11-30
出版物タイトル 岡山大学温泉研究所報告
55巻
資料タイプ その他
著者 岡山大学温泉研究所|
発行日 1985-03-30
出版物タイトル 岡山大学温泉研究所報告
56巻
資料タイプ その他
著者 岡山大学環境管理施設|
発行日 1980-07-01
出版物タイトル 岡山大学環境管理施設報
2巻
資料タイプ その他
著者 岡山大学環境管理施設|
発行日 1981-10-01
出版物タイトル 岡山大学環境管理施設報
3巻
資料タイプ その他