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JaLCDOI 10.18926/AMO/30289
フルテキストURL fulltext.pdf
著者 Sakamoto, Takeshi|
抄録

For the purpose of obtaining the dibasic acid indirect bilirubin in a pure state from the dried canine cholecystic bile, an optimal developing solvent was selected by paper partition chromatography as a preliminary experiment, and it was isolated on cellulose column as an applied experiment. 1. The dibasic acid indirect bilirubin was separable at the starting point in a pure state by paper chromatography under development with the top layer of a n-butanol, acetic acid, water mixture (4:1:5). 2. The dibasic acid indirect bilirubin formed a fixed band at the upper starting place on cellulose column under development with the top layer of a n-butanol, acetic acid, water mixture (4:1:5), and no other substance could be detected there. 3. The dibasic acid indirect bilirubin existing in the fixed band could be eluted out into chloroform with a 1% acetic acid solution. An orange yellow powder was obtained from the eluate by evaporating the solvent in vacuo. 4. Thus separated orange yellow powder agreed well with the crystalline bilirubin in the solubility into organic or inorganic solvents and in the spectrochemical characteristics as well as in the chemical properties.

Amo Type Article
出版物タイトル Acta Medicinae Okayama
発行日 1956-09
10巻
4号
出版者 Okayama University Medical School
開始ページ 253
終了ページ 260
NCID AA00041342
資料タイプ 学術雑誌論文
言語 英語
論文のバージョン publisher
査読 有り
NAID 120002305034
著者 Takahashi, Norio| Kayano, Takeshi| Miyata, Koji| Ohashi, Ken|
発行日 1999-5
出版物タイトル Magnetics
35巻
3号
資料タイプ 学術雑誌論文
著者 Takahashi, Norio| Suenaga, Ryousuke| Miyata, Koji| Ohashi, Ken|
発行日 2003-5
出版物タイトル Magnetics
39巻
3号
資料タイプ 学術雑誌論文
著者 Takahashi, Norio| Suenaga, Ryousuke| Miyata, Koji| Ohashi, Ken|
発行日 2006-5
出版物タイトル Magnetics Conference
資料タイプ 学術雑誌論文
著者 Takahashi, Norio| Ebihara, Kenji| Yoshida, Koji| Nakata, Takayoshi| Ohashi, Ken| Miyata, Koji|
発行日 1996-5
出版物タイトル Magnetics
32巻
3号
資料タイプ 学術雑誌論文
著者 Yamakawa, Junji| Tanabe, Mitsuo| Shimada, Kazumasa| Henmi, Chiyoko|
発行日 2000-09-20
資料タイプ 学術雑誌論文
著者 Tsujita-Kyutoku, Miki| Yuri, Takashi| Danbara, Naoyuki| Senzaki, Hideto| Kiyozuka, Yasuhiko| Uehara, Norihisa| Takada, Hideho| Hada, Takahiko| Miyazawa, Teruo| Ogawa, Yutaka| Tsubura, Airo|
発行日 2004-04-26
出版物タイトル Breast Cancer Research
6巻
4号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/21341
タイトル(別表記) Causes and Prevention of Intestinal Adhesions Part 1. Surve of the Literature
フルテキストURL pitsr_031_040_053.pdf
著者 大谷 満|
抄録 1) Seven types of irritation causing intestinal adhesions are recognized in the literature : namely, a) mechanical injury; b) chemical injury; c) thermal injury; d) bacterial infection; e) foreign body; f) blood; and g) exsiccation. Certain minor differences of opinion exist among investigators, according to the experimental methods and the experimental animals used, and blood is not universally accepted as a cause of adhesions. The author believes, however, that the above list includes all of the etiological factors so far recognized in the literature. 2) The mechanism of intestinal adhesions is similar to that of wound healing. The problem of fibre synthesis is still unsolved, despite many advances in electlon microscopy, histochemistory and X-ray analysis. In recent years it has been accepted that fibres are synthesized in extra-cellular space from cytoplasmic materials derived from either mesenchymal cells or fibroblasts, and from polysaccharides in ground substances, althoughth eexact kind of polysaccharides which plays an important role in this process is still unknown. 3) Many papers are recognized with the prevention and treament of adhesions. These may be devided into six groups according to the method suggested: a) limitation of the original peritoneal injury; b) prevention of the coagulation of the exudate; c) avoidance of prolonged contact between the injured surfaces; d) removal of the fibrin after its formation; e) stopping or slowing down of the proliferation of fibroblasts; f) prevention of further obstruction by means of controlling the area of damaged intestine in stepladder fashion, the so-called the plication method. 1. It is the common practice of surgeons to limit the original peritoneal lllJury by laparotomy. Experimental studies have demonstrated that peritonealization of an area denuded of serosa often results in more extensive adhesions. 2. To prevent coagulation of the exudate, Lehman and Boys and other investigators used heparin and dicumarol. The role of heparin in the prevention of adhesions may be summarized as follow: there is a short time interval separating the production of the exudate and its subsequent coagulation with the deposition of fibrin on injured serosal surfaces. Anticoagulants of various types should be effective in preventing this fibrin formation if it is assumed that the coagulation mechanism of both exudate and blood is the same. Though the use of heparin and dicumarol has demonstrated a preventive effect on adhesion formation in experimental animals, many surgeons believe that the risk of hemorrhage from heparin and dicumarol outweighs their possible benefit in the prevention of adhesions. 3. To prevent prolonged contact between injured surfaces, amnion, omental and mesothelial graft, and so on, have been used without success. The stimulation of peristalsis by means of prostigmin and early feeding, however, appears to be effective in the prevention of adhesions, although its use in clinical cases has not been reported. 4. The experimental data indicates that streptokinase alone has no preventive effect on the formation of adhesions, because fibrinolysis is facilitated only by the existence of activated human plasmin. Concernig the use of hyaluronidase, this is an enzyme with the property of hydrolyzing hyaluronic acid, one of the polysaccharides that constitutes the intercellular ground substances. Experimental studies on the use of this material indicate, in summary, that topically administered hyaluronidase reduces the number of adhesions and particularly their density. The reason why hyaluronidase is effective in the prevention of adhesions is still unknown. 5. The use of corticoids and ACTH, according to all available experimental data, appears to delay the formation of adhesions and to prevent talc-induced adhesions, possibly by increasing the absorption of talc. In administrating corticoids, however, their tendency to delay wound healing, to perforate the intestinal wall, and to induce hemorrhage must be taken into account. 6. Experimental study and clinical USe of the plication method demonstrate that in patients with severe recurrent adhesions, or in those for whom the afore-mentio ned methods have been ineffective, this procedure is probably the most effective therapy available.
出版物タイトル 岡山大学温泉研究所報告
発行日 1963-01-25
31巻
開始ページ 40
終了ページ 53
ISSN 0369-7142
関連URL http://eprints.lib.okayama-u.ac.jp/21336
言語 日本語
論文のバージョン publisher
NAID 120002310946
JaLCDOI 10.18926/21334
タイトル(別表記) The Geochemistry of Rocks from Asama Volcano, Japan. New Approaches in the Quantitative Interpretation of the Chemical Composition of Volcanic Rocks
フルテキストURL pitsr_032_001_085.pdf
著者 松井 義人|
抄録 In dealing with the geochemistry of volcanic rocks, it appears imperative, first, to refine the procedure of rock analysis with respect to both major and minor components, and second, to improve present methods of interpreting analytical data on common rock suites such as basalts, andesites and dacites. In regard to the first problem, the rapid method of silicate analysis as described by Shapiro and Brannock (1956) and by Riley (1958) deserves special attention. With such a method it is possible to estimate the accuracy and precision of data with far greater ease than is possible with a classical one, yet without any loss of quality. For the determination of some components, however, it is felt that the procedures recommended previously lack precision and/or simplicity. In Part I of this paper, new methods are suggested for these components. The sum of Mg, Ca and Mn is titrated with EDTA in the presence of Al, Fe and other metals, using thymolphthalein complexone as indicator at pH 10-10.5. The sum of Al and Fe is determined by the back-titration of excess EDTA with the standard Cu solution. PAN is used as indicator at pH about 4, and tartrate is added as the masking agent of Ti. Na and K are determined by flame photometry using very dilute solutions (1-5ppm Na or K), without the separation of other metals and without the use of the internal standard. Sr is included in the scheme of analysis, and is determined by flame photometry according to the standard addition technique. These procedures are tested for their accuracy using the standard samples G-1 and W-1 (Tables 3, 5, 9, 12 and 15). Procedures for other components are also described in the text in full detail. The system of analytical procedures recommended is shown in Table 16. To investigate the problem of the interpretation of compositional variation, typical rocks from Asama volcano and the surrounding area were selected, namely, andesites and dacites of calc-alkaline type. Twenty-one samples, described in Tables 18 and 19, are analyzed according to the above procedures. Results are shown in Table 20. Variation diagrams are presented in Figs. 3 to 5. Since it may be questioned whether the "trend" seen in the diagrams implies a genetic relationship, a least squares approximation technique has been introduced in order to determine whether the composition of the main components of a rock (F) can be expressed by the linear combination of a selected set of compositions of a magma and the phenocrysts crystallized from it : F(o)=F(1)x(1)+F(2)x(2)+······+F(m)x(m) ······(1) where F(1), F(2), ... denote the compositions of a magma and minerals, and F(o) is the calculated composition of F. These calculations lead to the conclusion that there are at least two series of rocks in Asama (Tables 25 to 30 and Fig. 9), distinguished from each other mainly by their K(2)O content. Those rocks showing features of assimilation (Aramaki, 1963) all belong to the K(2)O-rich series. Contents of minor components such as TiO(2), MnO, P(2)O(5) and SrO are analyzed by the linear regression technique in two ways, for example : TiO(2)(o)=C(1)x(1)+C(2)x(2)+ ······(2) and TiO(2)(o)=aMgO+bFe(o) +cK(2)O ······(3) These methods are found useful in discriminating rocks of different ongm and in distinguishing the characteristic behavior of each component. Results of calculations (Tables 31 to 34) support the conclusion reached by calculations based on the contents of major components.
出版物タイトル 岡山大学温泉研究所報告
発行日 1963-10-25
32巻
開始ページ 1
終了ページ 85
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310984
JaLCDOI 10.18926/21205
タイトル(別表記) Hydrogen and oxygen isotopic ratios of thermal and mineral springs in Arima area
フルテキストURL pitsr_043_015_028.pdf
著者 松葉谷 治| 酒井 均| 鶴巻 道二|
抄録 Saline waters of thermal and mineral springs in Arima area, at Takarazuka, and in Ishibotoke area of Kawachinagano City indicate wide ranges of δD and δ(18)O values (Table 1). Excellent linearity exists between the δD and δ(18)O values (Fig. 1) and between the δ(18)O value and the chloride concentration (Fig. 2). These facts as well as the chemical evidence of the previous investigators strongly support the view that Arima springs are admixtures of a single deep brine and local ground water (TSURUMAKI, 1964). The deep brine may have the δ(18)O value of +8.0~+8.5‰, the δD value of -25~-30‰, and the chloride concentration of 1.20~1.25 eq/l, which were estimated from the water of the maximum salinity so far reported. Because the thermal and mineral springs in Arima area closely associate with the upper Cretaceous granitic rocks, and the estimated δ(18)O value of the deep brine is similar to a value of water in isotopic equilibrium with those granitic rocks at 500~600℃, the deep brine of Arima might have been the magmatic water of those granitic rocks. The mineral springs at Takarazuka and in Ishibotoke area also show the similar linearity among Cl(-), δ(18)O and δD to those in Arima area. Therefore it is assumed that the mineral springs at Takarazuka may be of the same origin as that in Arima area, and the mineral springs in Ishibotoke area might have been the fluid associated with Ryoke metamorphic rocks. Alternatively, the deep brine in Arima area may be isotopically and chemically similar to the saline formation waters in Illinois basin (GRAF et al., 1966). The high δD values and salinities of those formation waters were attributed to the isotopic and chemical fractionation during the passage of water through sediments. The deep brine in Arima area may be genetically similar to those saline formation waters. If such a saline water could have formed in Osaka basin, it is not surprising to find out the similar brines at Arima and Ishibotoke which are the northwestern and southeastern rims of the basin, respectively. At the present, it cannot be answered which of these two models is more probable. Further studies on other saline springs fluid inclusions of Cretaceous granitic rocks may be useful in order to solve this problem.
出版物タイトル 岡山大学温泉研究所報告
発行日 1974-03-25
43巻
開始ページ 15
終了ページ 28
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310971
JaLCDOI 10.18926/21194
タイトル(別表記) Stable isotope study of the hotsprings and volcanoes of Hokkaido, Japan
フルテキストURL pitsr_047_055_067.pdf
著者 松葉谷 治| 酒井 均| 上田 晃| 堤 真| 日下部 実| 佐々木 昭|
抄録 Stable isotope ratios of hydrogen, oxygen, carbon and sulfur of precipitation, thermal and mineral waters, and volcanic gases were measured. The isotopic data combined with chemical and geological information were discussed in terms of origin and evolution of the hotsprings and volcanic gases. The hotsprings along the Uchiura Bay, Oshima Peninsula are mostly near-neutral NaCl-type thermal water and may be divided into three groups : (1) thermal waters isotopically similar to the precipitation of this area, (2) those similar in D/H to the local meteoric waters but enriched by 2 to 3‰ in (18)O compared to the latter, and (3) those enriched significantly in both D and (18)O relative to the local meteoric waters. The first and second types of thermal water probably form from local meteoric water which percolates through "Green Tuff" formations and acquires dissolved chemicals from them. However, high salt concentration and the oxygen isotope shift (thesecond type) may imply that the NaCl-type water of volcanic origin might be involved. On the other hand, the waters of the third group can be explained by mixing of modern sea water into the second type thermal water (in case of Yachigashira) or by incorporation of fossil sea water of Tertiary origin into modern meteoric water (Nigorigawa). Except for Esan, Noboribetsu and Atosanupuri volcanic systems, waters from all the hotsprings and volcanic fumaroles associated with Quaternary volcanic rocks are meteoric in origin. Thermal waters at Esan, Noboribetsu and Atosanupuri have δD = -30~-50 and δ(18)O = -1~+ 3‰ and are enriched in D and (18)O relative to local meteoric water of the respective area. The origin of these waters and the mechanism (s) controlling the isotope ratios could not be made clear by the present study. Interesting is the finding that at Esan, Noboribetsu and Atosanupuri, thermal waters are enriched in D and (18)O relative to near-by fumarolic gases. The enrichment factor is 18 to 26‰ for hydrogen and 4 to 6‰ for oxygen, implying that more than one stages of liquidvapor separation are taking place in underground hydrothermal systems.
出版物タイトル 岡山大学温泉研究所報告
発行日 1978-03-25
47巻
開始ページ 55
終了ページ 67
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 40000321119
JaLCDOI 10.18926/21159
タイトル(別表記) An isotope study of hot springs in Nagano Prefecture
フルテキストURL pitsr_050_017_024.pdf
著者 松葉谷 治| 酒井 均| 日下部 実| 佐々木 昭|
抄録 Water samples from 28 hotsprings and mineral springs in Nagano Prefecture, central Japan, were examined for their stable isotope ratios of hydrogen, oxygen, carbon, and sulfur. Spring waters of Kashio are highly saline and enriched in heavy isotopes of oxygen and hydrogen (δ(18)O=-2.5~-4.6‰, δD=-54~-57‰). Linear relationships among δD, δ(18)O, and Cl(-) suggest that spring waters are the mixtures of a deep brine and local surface water. Extrapolation of the linear relationships indicates that the deep brine is both isotopically and chemically very similar to the deep brine previously suggested for the springs of Arima, Takarazuka, and Ishibotoke of which δD, δ(18)O, and Cl(-) are estimated as -33‰, +8.0‰, and 44g/l, respectively. A common origin may be warranted among these postulated brines, while their provenance is yet to be worked out. The hot springs in Matsushiro are a Na-Ca-Cl type of high carbonate content. Their hydrogen and oxygen isotope ratios (δD=-71~-46‰, δ(18)O=-9.1~-2.0‰) are higher than the local surface water. On the basis of the relationships among δD, δ(18)O, and Cl(-), they are considered to be the mixtures of fossil sea water and certain water of meteoric origin of which Cl(-) is about 4g/l and δ(18)O is higher by about 3‰ than the local surface water. The latter may be meteoric water circulating in the marine sedimentary formations (Green Tuff formations) with soluble sea salts. Isotopic exchange with carbonate minerals in the formations explains its (18)O enrichment. Spring waters from Yashio and Isobe (Gunma Pref.) as well as Yunosawa and Yatate (Akita Pref.) were previously interpreted to be mixtures of fossil sea water and local surface water of low Cl(-) content. Re-examination of their data revealed that the meteoric waters responsible for these springs contain about 3g/l Cl(-), similar to the value obtained for Matsushiro. However, unlike Matsushiro, the meteoric waters in these areas are found to be isotopically similar to the local surface waters. Waters from other hot springs studied here are of simply meteoric origin, thus belonging to the GreenTuff type water previously defined.
出版物タイトル 岡山大学温泉研究所報告
発行日 1980-03-25
50巻
開始ページ 17
終了ページ 24
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310953
JaLCDOI 10.18926/21158
タイトル(別表記) Experimental study of sulfur isotope exchange between S0(4)(2-) and H(2)S (aqueous) at 400℃ and 1000 bars water pressure
フルテキストURL pitsr_050_001_015.pdf
著者 鎌田 恵美| 酒井 均| 木島 宣明|
抄録 Experimental procedures used in this study are the same as those developed by Sakai and Dickson (1978). 0.005 M Na(2)S(2)O(3) solutions were heated to 400℃ under 1000 bar water pressure in a gold bag of Dickson gold-bag equipment (Fig. 1). At an elevated temperature Na(2)S(2)O(3) quickly and completely decomposed into 1:1 mixture of SO(4)(2-) and H(2)S (eq. (1)) and subsequent isotope exchange (eq. (2)) was monitored by consecutively withdrawing aliquots of solution for chemical and isotopic analyses at desired time intervals. For the preparation of SO(2) for isotope analyses, 2 to 5 mg BaSO(4) was thoroughly mixed with silica glass powder of 10 times the BaSO(4) in weight and heated to 1400℃ or so in sealed, evacuated silica glass tubings (see Fig. 2 and equation (4)). The technique is a modification of Holt and Engelkemeir (1971). The (18)O/(16)O ratios of SO(2) thus formed stayed constant by exchange with silica glass powder (Fig. 3). Numerical data of the three runs performed in this study are summarized in Tables 1 to 3. In runs 2 and 3, a small aliquot of (34)S- enriched H(2)SO(4) was added into the starting solution and thus equilibrium was approached from above the quilibrium value (see Fig. 4). When isotope exchange occurs between two molecules, X and Y, the reaction rate, r, is related to the extent of exchange, F, at given time, t, by equation (17), where X and Y indicate concentrations of given species, α(e), α(o) and α denote the fractionation factor at equilibrium, at time t=0 and at an arbitrary time t, and F = (α - α(o))/(α(e) - α(0)) or the extent of isotope exchange. Assuming the exchange rate is of the first order with respect to both X and Y and to the β'th power of hydrogen ion activity, a(H)(+), eq. (17) reduces to eq. (19), where k(1) denotes the rate constant. If X, Y and pH of solution stayed constant during the run, the half-time, t(1/2), of the exchange reaction can be obtained graphically as shown in Fig. 5. The t(1/2) for runs 1, 2, and 3 are determined to be 5.8, 5.5 and 6.1 hrs, respectively. Introducing F=0.5 and t=t(1/2) into eq. (19), we obtain eq. (20) which is graphically shown in Fig. 6 using the data by the present work and those by Sakai and Dickson(1978). The numerical values of log k(1) + 0.16 may be obtained by extrapolating the lines to pH=0 and, from these values, the rate constant, k(1) , may be calculated for temperatures of 300° and 400℃. From these two values of k(1) and from the Arrhenius plot, the activation energy of the exchange reaction was calculated to be 22 kcal/mole, a much smaller value than 55 kcal/mole obtained by Igumnov (1977). The value of β is found to be 0.29 at 300℃ and 0.075 at 400℃, although the physico-chemical nature of β is not clear to the present authors. Using these values, eq. (24), where C is a constant, is derived which would enable us to calculate the t(1/2) of any system of known ΣS and pH. However, as we do not know yet how β varies with different systems, eq. (24) is applicable only to limited systems in which temperature, total sulfur contents and pH are similar to those of the present study. Fig. 7 illustrates how t(1/2) varies with pH and total sulfur content at 300° and 400℃ and predicts t(1/2) for some solutions obtainable by hydrothermal reactions of seawater with various igneous rocks. The average equilibrium fractionation factor at 400℃ obtained by this study is 1.0153, in good accord with 1.0151 given by Igumnov et al. (1977). Theoretical fractionation factors between SO(4)(2-) and H(2)S have been calculated by Sakai (1968) , who gives too high values compared to the experimental data obtained by this and other researchers (Fig. 9). In the present study, the reduced partition function ratio (R.P.F.R.) of SO(4)(2-) was recalculated using two sets of the vibrational frequencies of SO(4)(2-) (shown in Table 5) and the valence force fields of Heath and Linnett (1947), which reproduces the observed frequencies of SO(4)(2-) better than Urey-Bradley force field used by Sakai (1968). The results of new calculation are shown in Table 6. This table also includes the R.P.F.R. of H(2)S which was calculated by Thode et al. (1971). Using these new R.P.F.R. of SO(4)(2-) and H(2)S, the fractionation factors between SO(4)(2-) and H(2)S were calculated and are listed in the last column of Table 6 and plotted in Fig. 9. Fig. 9 indicates that the new calculation gives values more shifted from the experimental values than before. The major sulfate ions in our solution at 300° and 400℃ exist as NaSO(4)(-) (Sakai and Dickson, 1978; see also Table 4 of this paper) and, therefore, the measured fractionation factors are those between NaSO(4)(-) and H(2)S. The discrepancy between the theory and experiments may, at least, be partially explained by this fact, although other more important reasons, which are not known to us at the moment, may also exist.
出版物タイトル 岡山大学温泉研究所報告
発行日 1980-03-25
50巻
開始ページ 1
終了ページ 15
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310990
JaLCDOI 10.18926/21139
タイトル(別表記) Isotopic Analysis of Rb and Sr Using a Full Automatic Thermal Ionization Mass Spectrometer
フルテキストURL pitsr_052_051_070.pdf
著者 加々美 寛雄| 岡野 修| 須藤 宏| 本間 弘次|
抄録 Analytical method for strontium isotope ratios and rubidium and strontium concentrations has been established using a full automatic thermal ionization mass spectrometer. The machine is a modified model "MAT 260" of Varian MAT LTD. Each of simultaneously loaded thirteen samples is successively analysed full automatically following to a specific controling program which has been selected as being most suitable for each sample. However, the most characteristic feature of this machine compared to other types is computer controled peak jumping and peak centering before measurment of the signal of each peak. By this the accuracy of isotopic measurement has been surprisingly improved. Analytical procedures are described in detail which include decomposition of samples, separation of Rb and Sr, loading samples on filament and mass spectrometry. Accuracy and reproducibility of isotope analyses are excellent : 43 separate analyses of standard sample NBS 987 over one year gave a mean (87)Sr/(86)Sr ratio of 0.710238 (normalized to the (88)Sr/(86)Sr ratio of 8.375209) with a value of 20δ of 0.000008. The ratio obtained is slightly higher than the value of 0.71014 given by NBS, but it is almost identical to the mean of recently reported twenty analyses. Our determinations for Rb and Sr concentrations of standard samples are as follows : JG-1, Rb 184.4 ppm, Sr 185.5 ppm; JB-l, Rb 41.5Ppm, Sr 448.4 ppm , each of which is near the mean of reported values for corresponding element of the sample (ANDO et al., 1974). Concentrations of Rb and Sr in pure water and regents used in chemical treatement of samples were also measured; a possible error due to the contamination is negligible for most geochemical samples.
出版物タイトル 岡山大学温泉研究所報告
発行日 1982-03-25
52巻
開始ページ 51
終了ページ 70
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310968
JaLCDOI 10.18926/21115
タイトル(別表記) Hypnotic effect of the peloid therapy applied on the right hypochondrium in reference to plasma L-tryptophan
フルテキストURL pitsr_053_009_011.pdf
著者 森永 寛| 古元 順子| 古元 嘉昭|
抄録 Based on the EEG-observation of falling asleep when patients are under peloid therapy applied on the right hypochondrium, following assumption is made to clarify the mechanism of inducing sleep. While patients are under the peloid therapy, some chemical substance will be produced in circulating blood; L-tryptophan, an essential amino acid and a precursor of serotonin, gets over a blood-brain barrier easily to induce sleep. Six healthy volunteers, each sex by threes, were selected to apply peloid pack on the right hypochondrium for 30 minutes following 12-hour fasting. Significant increase in plasma L-tryptophan level was obtained in the clinical experiment. It is speculated from the preliminary data that L-tryptophan increased by the peloid therapy may possibly act as a specific physiological hypnotics.
出版物タイトル 岡山大学温泉研究所報告
発行日 1983-03-25
53巻
開始ページ 9
終了ページ 11
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002311031
JaLCDOI 10.18926/21086
タイトル(別表記) Effect of serial bathing on circadian variation of plasma metabolites in rats
フルテキストURL pitsr_056_035_043.pdf
著者 妹尾 敏伸| 原田 英雄| 御船 政明| 森永 寛|
抄録 The effect of serial bathing (10-minute bathing in city water or Misasa hot spring, 40℃, once daily for one or four weeks) on the circadian variations of plasma metabolites was studied in three groups of rats : hot spring bathing rats, city water bathing rats and non-treated rats. Plasma obtained by decapitation at 8:00, 12:00, 16:00, 20:00 and 24:00 hours was analysed for catecholamines (CA), free fatty acids (FFA), cholesterol (C) and glucose. 1) Noradrenaline (NA) and adrenaline (A) were significantly lower at 24:00 hours with significantly lower 24-hour average concentrations and also with significantly different diurnal patterns in the 1-week hot spring bathing rats; in the 4-week hot spring bathing rats, lower 24-hour average concentrarion of A was the only significant finding. The results suggest the suppressive effect of hot spring bathing on the sympathetic system or pituitary gland-adrenal medulla; they also suggest the adaptation to hot spring bathing. 2) Free fatty acids were significantly higher in the 1-week hot spring bathing rats at 12:00 hours as compared with non-treated rats and city water bathing rats. The 4-week hot spring bathing rats showed concentration of FFA not different from the remaining two groups of rats. No significant difference was noted in diurnal patterns among the three groups of rats. The results suggest that the high FFA concentrations in the 1-week hot spring bathing rats are related to the physico-chemical constituents of the hot spring to some extent and that the rats adapt themselves to bathing during the 4-week preriod. 3) Cholesterol was significantly lower in the 4-week hot spring bathing rats as compared with non-treated rats and city water bathing rats; no different diurnal patterns were noted among the three groups of rats. The results suggest the suppressive effect of 4-week hot spring bathing on plasma cholesterol concentrations as reported previously by us. 4) No Significant difference was noted in concentrations as well as in diurnal patterns of plasma glucose among the three groups of rats. The results suggest that bathing has no significan effect on concentrations and diurnal patterns of plasma glucose in healthy rats.
出版物タイトル 岡山大学温泉研究所報告
発行日 1985-03-30
56巻
開始ページ 35
終了ページ 43
ISSN 0369-7142
言語 日本語
論文のバージョン publisher
NAID 120002310969
著者 田羅 征伸| 船津 頼俊|
発行日 1998-08
出版物タイトル 環境制御
20巻
資料タイプ 紀要論文
著者 村本 茂樹| 大塚 和重|
発行日 2002-08
出版物タイトル 環境制御
24巻
資料タイプ 紀要論文
著者 山本 義明|
発行日 2003-09
出版物タイトル 岡山実験動物研究会報
20巻
資料タイプ その他
著者 嶋村 三智也|
発行日 2004-09
出版物タイトル 岡山実験動物研究会報
21巻
資料タイプ その他