| ID | 16838 |
| Eprint ID | 16838
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| フルテキストURL | |
| タイトル（別表記） | Studies on the diagnosis and treatment of human lung cancer using double-layered soft agar cloning assay I. In vitro chemosensitivity test on permanent cell lines from adeno-, epidermoid and small cell carcinoma of the lung using double-layered soft agar cloning assay
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| 著者 |
宮井 正博
岡山大学医学部第2内科学教室
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| 抄録 | An in vitro chemosensitivity test on permanent cell lines from adeno-, epidermoid and small cell carcinoma of the lung was performed using a double-layered soft agar cloning assay. Drugs tested in the present study were Adriamycin, 40497S, Mitomycin C, cis-Dichlorodiammineplatinum, Methotrexate and Vincristine. Adriamycin, 40497S, Mitomycin C and cis-Dichlorodiammineplatinum showed dose-dependent cytotoxity. Methotrexate and Vincristine did not show a significant cytotoxity when the cell lines were exposed for one hour. Differences in chemosensitivity to the six drugs examined among the three cell lines was relatively small e.g. the lethal dose 90% (LD90) of Adriamycin was 0.19mcg/ml in adenocarcinoma, 0.46mcg/ml in epidermoid carcinoma and 0.27mcg/ml in small cell carcinoma. The lack of a difference in chemosensitivity in vitro might be attributed to the fact that the cell lines had been established from bronchogenic carcinomas which were refractory to intensive combination chemotherapy.
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| キーワード | human lung cancer cell lines
in vitro chemosensitivity test
cloning assay
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| 発行日 | 1982-08-30
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| 出版物タイトル |
岡山医学会雑誌
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| 出版物タイトル（別表記） | Journal of Okayama Medical Association
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| 巻 | 94巻
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| 号 | 7-8号
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| 出版者 | 岡山医学会
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| 出版者（別表記） | Okayama Medical Association
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| 開始ページ | 673
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| 終了ページ | 681
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| ISSN | 0030-1558
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| NCID | AN00032489
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| 資料タイプ |
学術雑誌論文
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| オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/94/7-8/94_7-8_673/_article/-char/ja/
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| 関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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| 言語 |
日本語
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| 著作権者 | 岡山医学会
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| 論文のバージョン | publisher
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| 査読 |
有り
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| Eprints Journal Name | joma
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