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タイトル(別表記) Drug-induced liver injury due to the long-term oral administration of rosuvastatin
フルテキストURL 127_219.pdf
著者 大西 理乃| 狩山 和也| 湧田 暁子| 西村 守| 能祖 一裕|
抄録 A 67-year-old man was admitted to our hospital presenting with a liver injury. He had used several types of oral medication for the prior 2 years, including rosuvastatin calcium for hypertension, hyperlipidemia, and prostatic hypertrophy. His liver dysfunction was noted for the first time in February 2013, and at re-examination in March 2013 he showed exacerbation of the liver dysfunction, he was admitted to our hospital at that time. We stopped all of his oral medications, and his liver function improved steadily. We conducted a drug-induced lymphocyte transformation test (DLST), and the rosuvastatin calcium result was positive. He was diagnosed as having a drug-induced (by rosvastatin calcium) liver injury. He resumed oral medications other than rosuvastatin calcium from the time of discharge, with no exacerbation of liver dysfunction since then. Reports of drug-induced liver injury due to drugs with a long-term oral administration are extremely rare. We discuss the relevant literature herein.
キーワード 薬物性肝障害(drug induced liver injury) ロスバスタチンカルシウム(Rosuvastatin) スタチン(statin) DLST
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
巻 127巻
号 3号
開始ページ 219
終了ページ 222
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.219
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.219
NAID 130005116815
タイトル(別表記) A case report of giant ectopic pheochromocytoma conversion therapy with radioisotope therapy and chemotherapy followed by curative resection
フルテキストURL 127_213.pdf
著者 安井 和也| 楳田 祐三| 熊野 健二郎| 田端 雅弘| 大塚 文男| 八木 孝仁| 藤原 俊義|
抄録 A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected. The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs. On pathological and immunopathological findings, the tumor was diagnosed as ectopic pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs.
キーワード 異所性褐色細胞腫(ectopic pheochromocytoma) 化学療法(chemo therapy) 131I-MIBG
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
巻 127巻
号 3号
開始ページ 213
終了ページ 218
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.213
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.213
NAID 130005116814
タイトル(別表記) A primary diffuse large B-cell lymphoma of the liver treated with R-CHOP regimen
フルテキストURL 127_209.pdf
著者 岡田 博| 藤井 総一郎| 渡邉 謙太郎| 重松 照伸| 宮下 雄博| 岡崎 守宏| 小橋 春彦| 横山 元浩| 吉野 正|
抄録  A 78-year-old Japanese man was referred to our hospital after experiencing black feces. No abnormal finding was detected in the endoscopic examination of his stomach and large intestines. Computed tomography (CT) of the abdomen revealed a tumor lesion in the right lobe of the liver. A needle biopsy of the tumor under ultrasound guidance was performed. A pathological examination of the biopsy specimen showed a diffuse proliferation of lymphoma cells, which was compatible with diffuse large B-cell lymphoma (DLBCL). F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT demonstrated increased FDG uptake only in the liver tumor. We made the diagnosis of primary DLBCL of the liver. After six cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), the patient achieved complete remission and has maintained remission for 2 years since the diagnosis. The R-CHOP regimen might be effective therapy for primary DLBCL of the liver.
キーワード びまん性大細胞型B細胞リンパ腫(diffuse large B-cell lymphoma) 肝臓(liver) R-CHOP療法(R-CHOP regimen)
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
巻 127巻
号 3号
開始ページ 209
終了ページ 212
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.209
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.209
NAID 130005116809
タイトル(別表記) Non-high-output cardiac failure in patients undergoing hemodialysis through an arteriovenous shunt
フルテキストURL 127_203.pdf
著者 鵜川 豊世武|
抄録 Background: Hemodialysis-related heart failure has been considered to be associated with excessive blood flow through the arteriovenous (AV) shunt used for vascular access. However, some patients undergoing dialysis have heart failure in the absence of an increase in cardiac output (CO) related to shunt blood-flow loading because the loading cannot be compensated for by increasing CO. This condition may be challenging to manage ; thus, early diagnosis is important. Methods and Results: Twelve patients (mean age, 71 years ; 9 men) with end-stage renal disease, dialysis-related heart failure, a high brain natriuretic peptide (BNP) level, and a mean New York Heart Association (NYHA) class of II underwent AV shunt closure. Their cardiac index (CI), pre- and post-dialysis BNP levels, and several cardiac variables were assessed pre- and postoperatively. All patients achieved relief of heart failure symptoms and a reduction in NYHA class after AV closure, but six patients had a postoperative increase in CI (the "non-high-output" cardiac failure group), whereas the other six had a decrease in CI (the "high-output" cardiac failure group). The high-output patients had greater improvements in BNP levels and most cardiac variables compared to the non-high-output group ; therefore, the heart failure in the non-high-output patients was considered more serious than that in the high-output group. Conclusions: The selection of effective strategies for treating dialysis-related heart failure may depend partly on identifying which patients have non-high-output failure. Such identification requires serial measurements of BNP levels and evaluations of cardiac variables other than the ejection fraction.
キーワード 心拍出量(cardiac output) 心不全(heart failure) 脳性ナトリウム利尿ペプチド(brain natriuretic peptide) 非過大シャント心不全(non-high-output cardiac failure) 腎臓(kidney)
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
巻 127巻
号 3号
開始ページ 203
終了ページ 207
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.203
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.203
NAID 130005116810
タイトル(別表記) Discussing "anger" from the perspective of psychiatry with a focus on palliative care settings
フルテキストURL 127_197.pdf
著者 山田 了士|
キーワード 怒り 緩和ケア 自我消耗仮説 神経生理学 認知心理学
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
巻 127巻
号 3号
開始ページ 197
終了ページ 201
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.197
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.197
NAID 130005116808
タイトル(別表記) Basic and clinical research regarding vascular endothelial function
フルテキストURL 127_187.pdf
著者 塚原 宏一|
キーワード アルギニン代謝 一酸化窒素 ガス生物学 血管内皮学 酸化ストレス
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
巻 127巻
号 3号
開始ページ 187
終了ページ 195
ISSN 0030-1558
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.187
NAID 130005116819
タイトル(別表記) The 2014 Incentive Award of the Okayama Medical Association in General Medical Science (2014 Yuuki Prize)
フルテキストURL 127_175.pdf
著者 淺田 騰|
出版物タイトル 岡山医学会雑誌
発行日 2015-12-01
巻 127巻
号 3号
開始ページ 175
終了ページ 178
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.175
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.175
NAID 130005116820
JaLCDOI 10.18926/AMO/53674
フルテキストURL 69_5_279.pdf
著者 Saito, Yukie| Fujii, Yousuke| Yashiro, Masato| Tsuge, Mitsuru| Nosaka, Nobuyuki| Yamashita, Nobuko| Yamada, Mutsuko| Tsukahara, Hirokazu| Morishima, Tsuneo|
抄録 Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established. We examined the effects of edaravone, dexamethasone, and N-monomethyl-L-arginine (L-NMMA) on permeability changes in human pulmonary microvascular endothelial cells (PMVEC) under a hypercytokinemic state. Human PMVEC were seeded in a Boyden chamber. After monolayer confluence was achieved, the culture media were replaced respectively by culture media containing edaravone, dexamethasone, and L-NMMA. After 24-h incubation, the monolayer was stimulated with tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Fluorescein-labeled dextran was added. Then the trans-human PMVEC leak was measured. Expressions of vascular endothelial-cadherin (VE-cadherin) and zonula occludens-1 protein (ZO-1) were evaluated using real-time quantitative polymerase chain reaction and immunofluorescence microscopy. The results showed that TNF-α+IL-1β markedly increased pulmonary microvascular permeability. Pretreatment with edaravone, dexamethasone, or L-NMMA attenuated the hyperpermeability and inhibited the cytokine-induced reduction of VE-cadherin expression on immunofluorescence staining. Edaravone and dexamethasone increased the expression of ZO-1 at both the mRNA and protein levels. Edaravone and dexamethasone inhibited the permeability changes of human PMVEC, at least partly through an enhancement of VE-cadherin. Collectively, these results suggest a potential therapeutic approach for intervention in patients with ARDS.
キーワード pulmonary microvascular endothelial cells permeability edaravone vascular endothelial-cadherin zonula occludens-1 protein
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2015-10
巻 69巻
号 5号
出版者 Okayama University Medical School
開始ページ 279
終了ページ 290
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26490025
Web of Science KeyUT 000365519600004
著者 Aoba, Kana| Matsuo, Toshihiko| Hamasaki, Ichiro| Hasebe, Kayoko|
発行日 2015-04-07
出版物タイトル SpringerPlus
巻 4巻
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/53558
フルテキストURL 69_4_219.pdf
著者 Toshimori, Junichi| Nouso, Kazuhiro| Nakamura, Shinichiro| Wada, Nozomu| Morimoto, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Kuwaki, Kenji| Ohnishi, Hideki| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Yamamoto, Kazuhide|
抄録 We conducted a retrospective cohort study to investigate the predisposing factors for local recurrence and complications after percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). HCC patients (n=397) consecutively treated with RFA (256 males, 141 females, median age 69 years) were enrolled. In these patients, 1,455 nodules (median size 17mm) were ablated. Predisposing factors for overall recurrence and local recurrence in the context of tumor location and complications were examined. Local recurrence was observed for 113 of the 1,455 nodules. The 1-, 3- and 5-year local recurrence rates were 2.2オ, 7.4オ and 9.5オ, respectively. A multivariate Cox proportional hazard analysis revealed that large tumor size (>2cm), tumor location (adjacent to the major portal branch or hepatic vein), and small ablated margin (<3mm) were independent predisposing factors for local recurrence after RFA (HR=1.70-2.81). Tumor location (adjacent to the major portal branch, hepatic vein, or diaphragm) was also revealed as a risk factor for liver damage due to RFA. HCC adjacent to the major portal vein or hepatic vein was associated with a higher risk for local recurrence and for complications;therefore, special precautions are necessary when applying RFA to HCC near vessels even when the tumors are located at an easy-to-puncture site.
キーワード hepatocellular carcinoma radiofrequency ablation ablated margin tumor location
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2015-08
巻 69巻
号 4号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 226
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26289913
Web of Science KeyUT 000365519100005
JaLCDOI 10.18926/AMO/53557
フルテキストURL 69_4_213.pdf
著者 Yumoto, Tetsuya| Sato, Keiji| Ugawa, Toyomu| Ichiba, Shingo| Ujike, Yoshihito|
抄録 Hyponatremia, a common electrolyte disorder associated with traumatic brain injuries (TBIs), has high mortality and morbidity rates. The aim of this study was to identify the risk factors for hyponatremia associated with TBI. We retrospectively analyzed the cases of TBI patients who were admitted to the emergency intensive care unit at Okayama University Hospital between October 2011 and September 2014. A total of 82 TBI patients were enrolled. The incidences of hyponatremia (serum sodium level of<135mEq/L) and severe hyponatremia (serum sodium level of<130mEq/L) within the first 14 days after admission were 51オ (n=42) and 20オ (n=16), respectively. After admission, hyponatremia took a median period of 7 days to develop and lasted for a median of 3 days. Multivariate analysis demonstrated that higher fluid intake from days 1 to 3 and the presence of cranial fractures were risk factors for hyponatremia. The 58 patients with hyponatremia experienced fewer ventilator-free days, longer intensive care unit stays, and less favorable outcomes compared to the 24 patients without hyponatremia;however, these differences were not significant. Further studies are needed to determine the optimal management strategy for TBI-associated hyponatremia in the intensive care unit setting.
キーワード traumatic brain injury hyponatremia cranial fracture fluid intake
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2015-08
巻 69巻
号 4号
出版者 Okayama University Medical School
開始ページ 213
終了ページ 218
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26289912
Web of Science KeyUT 000365519100004
JaLCDOI 10.18926/AMO/53555
フルテキストURL 69_4_197.pdf
著者 Ishibashi, Naoki| Miyasho, Koji| Kitamura, Tetsuhisa| Ookuma, Takaaki| Kashitani, Nobuhiro| Beika, Nobuhiko| Yamashita, Takahiro| Ujike, Yoshihito|
抄録 We evaluated the hemodynamics and outcomes of septic shock (SS) patients who did not respond to fluid resuscitation, after treatment with or without intravenous calcium. We retrospectively collected information on 154 eligible SS patients who were admitted to Fukuyama City Hospital Emergency Medical Center and did not respond to fluid resuscitation. To compare their degree of hemodynamic impairment, we compared the changes in the vasoactive-inotropic score (VIS) in the calcium-treated group (n=112) and the noncalcium-treated group (n=42). We compared the length of stay in the intensive care unit (ICU) and hospital, in-hospital deaths, 28-day deaths, and changes in the Sequential Organ Failure Assessment score within 72h of ICU admission between the 2 groups. Changes in the VIS at 1h after the baseline time were significantly greater in the calcium-treated group than in the noncalcium-treated group (1.41 vs. -1.25, respectively;p<0.001). However, the changes in the VIS at 3, 6, 24, 48, and 72h did not differ between the 2 groups. The secondary outcomes also did not differ between the groups. Our findings indicate that calcium administered to SS patients might reduce their hemodynamic stabilization, but only for a short time after its administration.
キーワード hemodynamics calcium shock sepsis
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2015-08
巻 69巻
号 4号
出版者 Okayama University Medical School
開始ページ 197
終了ページ 204
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 26289910
Web of Science KeyUT 000365519100002
タイトル(別表記) Proton therapy
フルテキストURL 127_155.pdf
著者 勝井 邦彰| 沖本 智昭| 金澤 右|
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
巻 127巻
号 2号
開始ページ 155
終了ページ 157
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.155
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.155
NAID 130005096259
タイトル(別表記) An investigator initiated phase II clinical trial of tamibarotene (AM80G) for chronic graft-versus-host disease
フルテキストURL 127_133.pdf
著者 西森 久和| 前田 嘉信|
キーワード 臨床研究中核病院 慢性GVHD タミバロテン 同種造血幹細胞移植 Th17
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
巻 127巻
号 2号
開始ページ 133
終了ページ 137
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.133
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.133
NAID 130005096255
タイトル(別表記) A prospective cohort study to define the clinical and pathological features of lung cancers harboring HER2 gene aberrations (the HER2-CS Study) and a phase II study of trastuzumab emtansine (recombinant) in patients with HER2-positive non-small cell lung cancer who recurred, progressed after standard chemotherapy, or were primarily refractory to standard chemotherapy
フルテキストURL 127_127.pdf
著者 木浦 勝行| 堀田 勝幸| 佐藤 晃子| 大橋 圭明| 二宮 崇| 南 大輔| 田端 雅弘| 久保 寿夫| 加藤 有加| 平田 泰三|
キーワード 臨床研究中核病院 国立研究開発法人日本医療研究開発機構 文部科学省橋渡し研究加速ネットワークプログラム HER2-CS study trastuzumab emtansine
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
巻 127巻
号 2号
開始ページ 127
終了ページ 132
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.127
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.127
NAID 130005096256
タイトル(別表記) Peritoneal dialysis update
フルテキストURL 127_111.pdf
著者 杉山 斉|
キーワード 持続携行式腹膜透析(CAPD) 自動腹膜透析(APD) SMAP法 尿素Kt/V 腹膜平衡試験(peritoneal equilibration test:PET)
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
巻 127巻
号 2号
開始ページ 111
終了ページ 115
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.111
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.111
NAID 130005096252
タイトル(別表記) Role of COLXV/XVⅢ gene, Multiplexin, as a basement membrane toolkit
フルテキストURL 127_103.pdf
著者 大橋 俊孝|
キーワード 基底膜 ツールキット XV/XVⅢ型コラーゲン プロテオグリカン ミトコンドリア
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
巻 127巻
号 2号
開始ページ 103
終了ページ 109
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.103
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.103
NAID 130005096251
タイトル(別表記) The 2014 Incentive Award of the Okayama Medical Association in Neuroscience (2014 Niimi Prize)
フルテキストURL 127_99.pdf
著者 中村 絵里|
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
巻 127巻
号 2号
開始ページ 99
終了ページ 101
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.99
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.99
NAID 130005096247
タイトル(別表記) The 2014 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2014 Sunada Prize)
フルテキストURL 127_95.pdf
著者 時岡 浩二|
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
巻 127巻
号 2号
開始ページ 95
終了ページ 97
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.95
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.95
NAID 130005096249
タイトル(別表記) The 2014 Incentive Award of the Okayama Medical Association in Cancer Research (2014 Hayashibara Prize and Yamada Prize)
フルテキストURL 127_91.pdf
著者 矢野 修也|
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
巻 127巻
号 2号
開始ページ 91
終了ページ 94
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.127.91
言語 日本語
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.127.91
NAID 130005096248