| ID | 32092 |
| JaLCDOI | |
| フルテキストURL | |
| 著者 |
Araki, Hiroaki
Ehime University Hospital
Nagatani, Tadashi
Asahi Kasei Co.
Takao, Katsuyuki
Asahi Kasei Co.
Shibata, Kazuhiko
Okayama University
Gomita, Yutaka
Okayama University
|
| 抄録 | We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression. |
| キーワード | stress
depression
imipramine
forced-swim test
animal model
|
| Amo Type | Article
|
| 出版物タイトル |
Acta Medica Okayama
|
| 発行日 | 2004-12
|
| 巻 | 58巻
|
| 号 | 6号
|
| 出版者 | Okayama University Medical School
|
| 開始ページ | 271
|
| 終了ページ | 274
|
| ISSN | 0386-300X
|
| NCID | AA00508441
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
英語
|
| 論文のバージョン | publisher
|
| 査読 |
有り
|
| PubMed ID | |
| Web of Science KeyUT |
