ドリン剤中毒に関する研究 第1編 ドリン剤の毒性

Toxicity of drin compounds currently on market was investigated and the following results were obtained. 1. Endrin. The dose of LD50 was 5.2 mg/kg for mice and 13,7 mg/kg for rabbits when given subcutaneously, 6,6 mg/kg for mice and 5.2 mg/kg for rabbits when orally, and 54.8 mg/kg rats when given percutaneously. 2. Aldrin. The dose of LD50 was 49.2 mg/kg for mice and 56.6 mg/kg for rabbits when given subcutaneously, 64.8 mg/kg for mice and 36.7 mg/kg for rabbits when given orally, and 141.4 mg/kg for rats when given percutaneously. 3. Dieldrin. The dose of LD50 was 68.0 mg/kg for mice and 59.6 mg/kg for rabbits when given subcutaneously, 44.4 mg/kg for mice and 37.1 mg/kg for rabbits when given orally, and 186,6 mg/kg for rats when given percutaneously. 4. Toxic symptoms observed were episodic generalized seizure, salivation, restlessness, inactivity, loss of appetite, irritability, epiphora, fever, tachycardia, paralysis of four limbs, dyspnea, and cyanosis,