検索条件

閉じる

検索結果 18721 件

JaLCDOI 10.18926/AMO/54191
フルテキストURL 70_2_119.pdf
著者 Isozaki, Hiroshi| Matsumoto, Sasau| Murakami, Shigeki| Takama, Takehiro| Sho, Tatuo| Ishihara, Kiyohiro| Sakai, Kunihiko| Takeda, Masanori| Nakada, Koji| Fujiwara, Toshiyoshi|
抄録 Using the Postgastrectomy Syndrome Assessment Scale (PGSAS)-45, we compared the surgical outcomes and the quality of life (QOL) between patients undergoing limited gastrectomies and those undergoing conventional gastrectomies. In Oomoto Hospital between January 2004 and December 2013, a total of 124 patients who met the eligibility criteria were enrolled. Using the main outcome measures of PGSAS-45, we compared 4 types of limited gastrectomy procedures (1/2 distal gastrectomy [1/2DG] in 21 patients; pylorus-preserving gastrectomy [PPG] in 15 patients; segmental gastrectomy [SG] in 26 patients; and local resection [LR] in 13 patients) with conventional gastrectomy (total gastrectomy [TG] in 24 patients and 2/3 or more distal gastrectomy [WDG] in 25 patients). The TG group showed the worst QOL in almost all items of the main outcome measures. The 1/2DG, PPG, and SG groups showed better QOL than the WDG group in many of the main outcome measures, including the body weight ratio, total symptom score, ingested amount of food per meal, and the dissatisfaction for daily life subscale. The LR group showed a better intake of food than the 1/2DG, PPG, and SG groups. The body weight ratio of the LR group was better than that of the SG group. Diminished gastric resection preserved better QOL in patients with early gastric cancer.
キーワード limited gastrectomy early gastric cancer function preserving gastrectomy quality of life postgastrectomy syndrome
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2016-04
70巻
2号
出版者 Okayama University Medical School
開始ページ 119
終了ページ 130
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27094837
Web of Science KeyUT 000377626300007
JaLCDOI 10.18926/AMO/54190
フルテキストURL 70_2_111.pdf
著者 Takeda, Midori| Ikeda, Masanori| Satoh, Shinya| Dansako, Hiromichi| Wakita, Takaji| Kato, Nobuyuki|
抄録 Membrane transport probably participates in the lifecycle of hepatitis C virus (HCV). Rab proteins are essential host factors for HCV RNA replication, but these proteins’ roles in other steps of the HCV lifecycle are not clear. The tight junction (TJ) plays a key role in HCV infection. Rab13 regulates the endocytic recycling of the TJ-associated proteins. Here we investigated whether Rab13 is involved in the HCV entry step. We used HuH-7-derived RSc cells and Li23-derived D7 cells. To evaluate the effect of Rab13 in HCV infection, we transfected the cells with siRNA targeting Rab13 before HCV infection. The down-regulation of Rab13 inhibited HCV infection. The D7 cells had showed a greater inhibitory effect against HCV infection compared to that in the RSc cells by Rab13 knockdown. Next, to evaluate the effect of Rab13 after infection, we inoculated the cells with HCV before transfection of the siRNA. The down-regulation of Rab13 did not show any effects after HCV infection. We further examined whether Rab13 would influence HCV RNA replication by using HCV replicon-harboring cells. The results revealed that Rab13 did not affect the step of HCV RNA replication. These results suggest that Rab13 plays an important role in the step of HCV entry.
キーワード hepatitis C virus Rab13 occludin claudin 1
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2016-04
70巻
2号
出版者 Okayama University Medical School
開始ページ 111
終了ページ 118
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27094836
Web of Science KeyUT 000377626300006
JaLCDOI 10.18926/AMO/54189
フルテキストURL 70_2_103.pdf
著者 Mu Mu Shwe| Hlaing Myat Thu| Khin Saw Aye| Aye Aye Myint| Mya Thida| Khin Shwe Mar| Khin Khin Oo| Khin Sandar Aye| Shigeru Okada| Kyaw Zin Thant|
抄録 Molecular and epidemiologic investigations suggest a causal role for human papillomavirus (HPV) in anogenital cancers. This study identified oncogenic HPV genotypes in anogenital cancers among men and women in a 2013 cross-sectional descriptive study in Myanmar. In total, 100 biopsy tissues of histologically confirmed anogenital cancers collected in 2008-2012 were studied, including 30 penile and 9 anal cancers from Yangon General Hospital and 61 vulvar cancers from Central Women's Hospital, Yangon. HPV-DNA testing and genotyping were performed by polymerase chain reaction-restriction fragment length polymorphism. Overall, 34% of anogenital cancers were HPV-positive. HPV was found in 44.4% of anal (4/9), 36.1% of vulvar (22/61), and 26.7% of penile (8/30) cancers. The most frequent genotypes in anal cancers were HPV 16 (75%) and 18 (25%). In vulvar cancers, HPV 33 was most common (40.9%), followed by 16 (31.8%), 31 (22.7%), and 18 (4.6%). In penile cancers, HPV 16 (62.5%) was most common, followed by 33 (25%) and 18 (12.5%). This is the first report of evidencebased oncogenic HPV genotypes in anogenital cancers among men and women in Myanmar. This research provides valuable information for understanding the burden of HPV-associated cancers of the anus, penis, and vulva and considering the effectiveness of prophylactic HPV vaccination.
キーワード human papillomavirus (HPV) ano-genital cancer Myanmar genotyping of HPV cross-sectional study
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2016-04
70巻
2号
出版者 Okayama University Medical School
開始ページ 103
終了ページ 110
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27094835
Web of Science KeyUT 000377626300005
JaLCDOI 10.18926/AMO/54188
フルテキストURL 70_2_97.pdf
著者 Shinohara, Kensuke| Takigawa, Tomoyuki| Tanaka, Masato| Sugimoto, Yoshihisa| Arataki, Shinya| Ito, Yasuo| Ozaki, Toshifumi|
抄録 Vertical sacral fracture is one of the most difficult fractures to treat. Posterior fixation using spinal dual rods is a novel method for treating this fracture, but its biomechanical strength has not yet been reported. The aim of this study was to evaluate the biomechanical strength produced by posterior fixation using spinal instrumentation. Sacral fractures were created in eight pelvic bone models and classified into a posterior plate fixation group [P group, n=4] and a spinal instrumentation group [R group, n=4]. The biomechanical strength was tested by pushing down on the S1 vertebra from the top. The mean maximum loads were 1,057.4 N and 1,489.4 N in the P and R groups, respectively (p=0.014). The loads applied to the construct at displacements of 5mm and 7.5mm from the start of the universal testing machine loading were also significantly higher in the R group. The mean stiffness levels in the P and R groups were 88.3N/mm and 119.6N/mm, respectively (p=0.014). Posterior fixation using spinal instrumentation is biomechanically stronger than conventional posterior plate fixation. This procedure may be the optimal method for treating unstable sacral fracture fixation.
キーワード biomechanical comparison sacral fracture posterior fixation spinal instrumentation
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2016-04
70巻
2号
出版者 Okayama University Medical School
開始ページ 97
終了ページ 102
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27094834
Web of Science KeyUT 000377626300004
JaLCDOI 10.18926/AMO/54187
フルテキストURL 70_2_89.pdf
著者 Umehara, Norifumi| Mitani, Shigeru| Namba, Yoshifumi|
抄録 Total hip arthroplasty (THA) is an established treatment approach with which good recovery is expected in patients. However, the postoperative satisfaction of THA patients, and factors that affect their treatment outcomes are unclear. We investigated 125 Japanese patients who underwent a primary THA between January 2011 and August 2013. The posterolateral (PL) and muscle-sparing anterolateral (AL) surgical approaches were used. THA outcomes were evaluated using the Short Form-36 (SF-36) at preoperatively and 1 month, 3 months, 6 months, and 1 year postoperatively. Approach-based comparisons demonstrated a significantly higher mean score for physical functioning after 6 months, role physical at 1 year, and social functioning at 1 year in the AL group. No significant difference was observed for other subscale scores at any survey period. The age-based comparison often indicated significant increases of subscale scores in the younger patient group. Weight-based comparisons were not observed for any of the 8 subscales at any survey period. Surgical approach was not a factor affecting the patients’ postoperative quality of life, and the AL approach was not superior to the other surgical approaches involving myotenotomy. Moreover, the THA treatment outcomes were better in the younger patients, and obesity did not affect the outcomes.
キーワード total hip arthroplasty quality of life approach
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2016-04
70巻
2号
出版者 Okayama University Medical School
開始ページ 89
終了ページ 95
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27094833
Web of Science KeyUT 000377626300003
JaLCDOI 10.18926/AMO/54186
フルテキストURL 70_2_75.pdf
著者 Sejima, Hiroe| Satoh, Shinya| Dansako, Hiromichi| Honda, Masao| Kaneko, Shuichi| Ikeda, Masanori| Kato, Nobuyuki|
抄録 The mechanisms of hepatitis C virus (HCV)-associated hepatocarcinogenesis and disease progression are unclear. We previously observed that the expression level of carboxypeptidase B2 (CPB2) gene was remarkably suppressed by persistent HCV RNA replication in human hepatoma cell line Li23-derived cells. The results of the present study demonstrated that the CPB2 expression in patients with chronic hepatitis C was inversely correlated with several risk factors of hepatic fibrosis or steatosis, although ectopic CPB2 expression did not suppress the expression of fibrogenic or lipogenic genes. The suppressed CPB2 expression was restored by treatment with 5-azacytidine. To clarify the mechanism underlying this phenomenon, we analyzed the CPB2 promoter, and the results revealed that (1) hepatocyte nuclear factor 1 (HNF1), especially HNF1α, was essential for the CPB2 promoter, and (2) CPB2 promoter was not methylated by persistent HCV RNA replication. The expression levels of HNF1α and HNF1β were also not changed by persistent HCV RNA replication. These results suggest the existence of 5-azacytidine-inducible or -reducible unknown factor(s) that can control the CPB2 expression. To evaluate this idea we performed a microarray analysis, and several gene candidates corresponding to the suggested factor(s) were identified.
キーワード persistent hepatitis C virus replication carboxypeptidase B2 suppression mechanism of CPB2 expression DNA methylation hepatocyte nuclear factor 1
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2016-04
70巻
2号
出版者 Okayama University Medical School
開始ページ 75
終了ページ 88
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27094832
Web of Science KeyUT 000377626300002
JaLCDOI 10.18926/AMO/54185
フルテキストURL 70_2_69.pdf
著者 Kobayashi, Yasuyuki| Kurahashi, Hiroaki| Matsumoto, Yuko| Wada, Koichiro| Sasaki, Katsumi| Araki, Motoo| Ebara, Shin| Watanabe, Toyohiko| Nasu, Yasutomo|
抄録 In minimally invasive partial nephrectomy (MIPN), it is important to preoperatively predict the degree of difficulty of tumor resection. When severe adhesions occur between the renal capsule and perinephric adipose tissue, detachment can be difficult. Preoperative prediction of adhesion is thought to be useful in the selection of surgical procedure. Subjects were 63 patients of a single surgeon who had received MIPN between April 2008 and August 2013 at Okayama University Hospital. Of these patients, this study followed 47 in whom the presence or absence of adhesions between the renal capsule and perinephric adipose tissue was confirmed using intraoperative videos. Data collected included: sex, BMI, CT finding (presence of fibroids in perinephric adipose tissue), comorbidities and lifestyle. Adhesion was observed in 7 patients (14.9%). The mean operative time was 291.6min in the adhesion group, and 226.3min in the group without. The increased time in the adhesions group was significant (p<0.05). Predictive factors were a positive CT finding for fibroid structure and comorbidity of hypertension (p<0.05). In MIPN, difficulty of surgery can be affected by the presence of adhesion of the perinephric adipose tissue. Predicting such adhesion from preoperative CT is thus important.
キーワード renal cell carcinoma partial nephrectomy renal capsule adhension
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2016-04
70巻
2号
出版者 Okayama University Medical School
開始ページ 69
終了ページ 74
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27094831
Web of Science KeyUT 000377626300001
JaLCDOI 10.18926/OLR/54178
タイトル(別表記) Supreme Court Decision from the Viewpoint of a Practicing Lawyer
フルテキストURL olr_016_071_084.pdf
著者 湯川 二朗|
出版物タイトル 臨床法務研究
発行日 2016-03
16巻
開始ページ 71
終了ページ 84
ISSN 1881-1485
言語 日本語
論文のバージョン publisher
NAID 120005745578
JaLCDOI 10.18926/OLR/54175
タイトル(別表記) A Note on the Continuing Legal Education Program for In-house Lawyers(Part 2)
フルテキストURL olr_016_015_026.pdf
著者 藤本 和也|
出版物タイトル 臨床法務研究
発行日 2016-03
16巻
開始ページ 15
終了ページ 26
ISSN 1881-1485
言語 日本語
論文のバージョン publisher
NAID 120005745575
JaLCDOI 10.18926/OER/54168
タイトル(別表記) Participatory Democracy in a Diverse Society: Civic Participation in Portland, Oregon
フルテキストURL oer_047_3_209_225.pdf
著者 岩淵 泰|
キーワード participatory democracy equity participatory programs urban development MACHIZUKURI Office of Neighborhood Involvement(ONI)
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-03-19
47巻
3号
開始ページ 209
終了ページ 225
ISSN 0386-3069
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740506
JaLCDOI 10.18926/OER/54165
タイトル(別表記) Estimation of Saving Rates by Age Group in Japan Using National Survey of Family Income and Expenditure
フルテキストURL oer_047_3_155_172.pdf
著者 釣 雅雄|
キーワード Saving rates Disposal income Consumption expenditure Decreasing birthrate Aging population
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-03-19
47巻
3号
開始ページ 155
終了ページ 172
ISSN 0386-3069
関連URL http://www.e.okayama-u.ac.jp/gakkai/
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740503
JaLCDOI 10.18926/OER/54163
タイトル(別表記) A Survey of the Experimental Studies on Leniency Programs
フルテキストURL oer_047_3_123_139.pdf
著者 濱口 泰代|
キーワード leniency antitrust policy oligopoly cartel
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-03-19
47巻
3号
開始ページ 123
終了ページ 139
ISSN 0386-3069
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740501
JaLCDOI 10.18926/OER/54161
タイトル(別表記) Mixed Oligopoly and Product Differentiation: The Privatization Effect of a Public Firm in the General Case of the Number of Private Firms
フルテキストURL oer_047_3_083_095.pdf
著者 松本 直樹|
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-03-19
47巻
3号
開始ページ 83
終了ページ 95
ISSN 0386-3069
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740499
JaLCDOI 10.18926/OER/54160
タイトル(別表記) Collaboration between the International Student Advisor's Room of the International Center and a Lecturer in Charge of International Students in the Faculty of Economics: April 2000 - March 2015
フルテキストURL oer_047_3_065_081.pdf
著者 岡 益巳| 廣田 陽子|
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-03-19
47巻
3号
開始ページ 65
終了ページ 81
ISSN 0386-3069
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740498
JaLCDOI 10.18926/OER/54158
タイトル(別表記) A Circulation Analysis of Regional Industrial Structure in Niimi City, Okayama
フルテキストURL oer_047_3_029_045.pdf
著者 中村 良平| 小林 義明|
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-03-19
47巻
3号
開始ページ 29
終了ページ 45
ISSN 0386-3069
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740496
JaLCDOI 10.18926/OER/54157
タイトル(別表記) A Study of Assistance on Supporters of Regional Revitalization and Their Retention: “Local Community Revitalizing Troops” Project and Community Sustainability
フルテキストURL oer_047_3_001_027.pdf
著者 中尾 裕幸| 平野 正樹|
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-03-19
47巻
3号
開始ページ 1
終了ページ 27
ISSN 0386-3069
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740495
JaLCDOI 10.18926/OER/54147
タイトル(別表記) Strong Law of Large Numbers on a Polymer Model with Response Functions for Public Information
フルテキストURL oer_047_2_117_127.pdf
著者 村井 浄信|
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-02-23
47巻
2号
開始ページ 117
終了ページ 127
ISSN 0386-3069
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740487
JaLCDOI 10.18926/OER/54146
タイトル(別表記) Entry Strategy by Online in Professional Service Business: From a Viewpoint of Justice Theory
フルテキストURL oer_047_2_095_116.pdf
著者 北 真収|
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-02-23
47巻
2号
開始ページ 95
終了ページ 116
ISSN 0386-3069
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740486
JaLCDOI 10.18926/OER/54144
タイトル(別表記) Trends in Okayama Prefectural Finance after the Japanese asset price bubble: A review of financial conditions during the Nagano and Ishii administrations
フルテキストURL oer_047_2_053_080.pdf
著者 亀山 定司| 平野 正樹|
出版物タイトル 岡山大学経済学会雑誌
発行日 2016-02-23
47巻
2号
開始ページ 53
終了ページ 80
ISSN 0386-3069
言語 日本語
著作権者 Copyright © 2016 岡山大学経済学会
論文のバージョン publisher
NAID 120005740484
タイトル(別表記) “Weight of Evidence” in a Criminal Trial
フルテキストURL olj_065_3_4_1006_1076.pdf
著者 原田 和往|
出版物タイトル 岡山大學法學會雜誌
発行日 2016-03-18
65巻
3・4号
開始ページ 1006
終了ページ 1076
ISSN 0386-3050
言語 日本語
論文のバージョン publisher
NAID 120005740478