Ciclosporin 投与におけるリンパ球中濃度及びNK活性

Ciclosporin is an effective immunosuppressant for kidney transplantation, although it has the side effect of nephrotoxicity. Ordinarily, the optimal dosage of Ciclosporin is determined by the serum trough level. However, it might be better to make the determination from the concentration in immunocompetent cells. In this report, the serum level of Ciclosporin was compared with the lymphocyte concentration along with the inhibiting activity to NK cells. In in vivo administration, Ciclosporin levels in serum and lymphocytes increased in proportion to the dosage. The suppression of NK activity correlated with the dosage. The suppression of NK activity ceased within 4 days after cessation of administration. In in vitro administration, the Ciclosporin level in lymphocytes increased in proportion to the dosage. The suppression of NK activity correlated with its level in the lymphocytes. Ciclosporin successfully suppressed NK activity against both K562 cells and skin cells.

原著