検索結果 200 件
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| フルテキストURL | 76_5_503.pdf |
| 著者 | Ogawa, Hirohito| Honda, Tomoyuki| |
| 抄録 | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| キーワード | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 503 |
| 終了ページ | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/63887 |
|---|---|
| フルテキストURL | 76_4_359.pdf |
| 著者 | Hiramatsu-Asano, Sumie| Wada, Jun| |
| 抄録 | Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. |
| キーワード | systemic lupus erythematosus miRNA miRNA targeting therapy |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 359 |
| 終了ページ | 371 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123150 |
| Web of Science KeyUT | 000882167300002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ren, Liangliang| Jiang, Minxiao| Xue, Dingwei| Wang, Huan| Lu, Zeyi| Ding, Lifeng| Xie, Haiyun| Wang, Ruyue| Luo, Wenqin| Xu, Li| Wang, Mingchao| Yu, Shicheng| Cheng, Sheng| Xia, Liqun| Yu, Haifeng| Huang, Peng| Xu, Naijin| Li, Gonghui| |
| キーワード | Bladder cancer nitroxoline metastasis circNDRG1 microRNA |
| 発行日 | 2022-08-08 |
| 出版物タイトル | International Journal Of Biological Sciences |
| 巻 | 18巻 |
| 号 | 13号 |
| 出版者 | Ivyspring International Publisher |
| 開始ページ | 5207 |
| 終了ページ | 5220 |
| ISSN | 1449-2288 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 35982887 |
| DOI | 10.7150/ijbs.69373 |
| Web of Science KeyUT | 000842375500006 |
| 関連URL | isVersionOf https://doi.org/10.7150/ijbs.69373 |
| フルテキストURL | fulltext20220316-1.pdf table20220316-1.pdf figure1_20220316-1.pdf figure2_20220316-1.pdf |
|---|---|
| 著者 | Maruyama, Takayuki| Kobayashi, Terumasa| Sugiura, Yoshio| Yoneda, Toshiki| Ekuni, Daisuke| Morita, Manabu| |
| キーワード | experimental animal model microRNA mRNA obesity periodontitis |
| 備考 | This is the peer reviewed version of the following article: [Maruyama, T, Kobayashi, T, Sugiura, Y, Yoneda, T, Ekuni, D, Morita, M. Association between serum miRNAs and gingival gene expression in an obese rat model. J Periodont Res. 2022; 00: 1– 8. doi:10.1111/jre.12979], which has been published in final form at https://doi.org/10.1111/jre.12979. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext is available in Mar. 2023.| |
| 発行日 | 2022-3-2 |
| 出版物タイトル | Journal of Periodontal Research |
| 巻 | 57巻 |
| 号 | 3号 |
| 出版者 | Wiley |
| 開始ページ | 502 |
| 終了ページ | 509 |
| ISSN | 0022-3484 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
| 論文のバージョン | author |
| PubMed ID | 35234284 |
| DOI | 10.1111/jre.12979 |
| Web of Science KeyUT | 000762837900001 |
| 関連URL | isVersionOf https://doi.org/10.1111/jre.12979 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamaguchi, Satoshi| Zhang, Dongxiao| Katayama, Akihiro| Kurooka, Naoko| Sugawara, Ryosuke| Albuayjan, Haya Hamed Hassan| Nakatsuka, Atsuko| Eguchi, Jun| Wada, Jun| |
| キーワード | non-coding RNAs microRNA adipose tissues Adipogenesis mTORC1 |
| 発行日 | 2022-01-03 |
| 出版物タイトル | Frontiers In Endocrinology |
| 巻 | 12巻 |
| 出版者 | Frontiers Media SA |
| 開始ページ | 750261 |
| ISSN | 1664-2392 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Yamaguchi, Zhang, Katayama, Kurooka, Sugawara, Albuayjan, Nakatsuka, Eguchi and Wada. |
| 論文のバージョン | publisher |
| PubMed ID | 35046889 |
| DOI | 10.3389/fendo.2021.750261 |
| Web of Science KeyUT | 000745695800001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fendo.2021.750261 |
| JaLCDOI | 10.18926/AMO/62806 |
|---|---|
| フルテキストURL | 75_6_677.pdf |
| 著者 | Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi| |
| 抄録 | Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy. |
| キーワード | endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 677 |
| 終了ページ | 684 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955534 |
| Web of Science KeyUT | 000735297900002 |
| NAID | 120007180286 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Watanabe, Kazunori| Nawachi, Tomoko| Okutani, Ruriko| Ohtsuki, Takashi| |
| 発行日 | 2021-07-22 |
| 出版物タイトル | scientific reports |
| 巻 | 11巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 14936 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2021 |
| 論文のバージョン | publisher |
| PubMed ID | 34294789 |
| DOI | 10.1038/s41598-021-94249-7 |
| Web of Science KeyUT | 000682800400009 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-021-94249-7 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fujimori, Kohei| Yoneda, Toshiki| Tomofuji, Takaaki| Ekuni, Daisuke| Azuma, Tetsuji| Maruyama, Takayuki| Sugiura, Yoshio| Morita, Manabu| |
| キーワード | saliva periodontitis microRNAs precision medicine cohort studies |
| 発行日 | 2021-07-29 |
| 出版物タイトル | International Journal of Environmental Research and Public Health |
| 巻 | 18巻 |
| 号 | 15号 |
| 出版者 | MDPI |
| 開始ページ | 8010 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 34360304 |
| DOI | 10.3390/ijerph18158010 |
| Web of Science KeyUT | 000681921900001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph18158010 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ueta, Eijiro| Tsutsumi, Koichiro| Kato, Hironari| Matsushita, Hiroshi| Shiraha, Hidenori| Fujii, Masakuni| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Okada, Hiroyuki| |
| 発行日 | 2021-06-10 |
| 出版物タイトル | Scientific Reports |
| 巻 | 11巻 |
| 号 | 1号 |
| 出版者 | Nature Research |
| 開始ページ | 12298 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2021 |
| 論文のバージョン | publisher |
| PubMed ID | 34112884 |
| DOI | 10.1038/s41598-021-91804-0 |
| Web of Science KeyUT | 000663785600048 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-021-91804-0 |
| フルテキストURL | K0006315_abstract_review.pdf K0006315_fulltext.pdf K0006315_summary.pdf |
|---|---|
| 著者 | Moh-Moh-Aung, Aye| |
| 発行日 | 2021-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6315号 |
| 学位授与年月日 | 2021-03-25 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © The Author(s) 2020 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hiramatsu-Asano, Sumie| Sunahori-Watanabe, Katsue| Zeggar, Sonia| Katsuyama, Eri| Mukai, Tomoyuki| Morita, Yoshitaka| Wada, Jun| |
| キーワード | miR-223-3p S1pr1 S1PR1(+)CD4(+) T cells lupus nephritis MRL/MpJ-Faslpr/J mice |
| 発行日 | 2021-01-26 |
| 出版物タイトル | Frontiers in Immunology |
| 巻 | 11巻 |
| 出版者 | Frontiers Media |
| 開始ページ | 616141 |
| ISSN | 1664-3224 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 Hiramatsu-Asano, Sunahori-Watanabe, Zeggar, Katsuyama, Mukai, Morita and Wada. |
| 論文のバージョン | publisher |
| PubMed ID | 33574820 |
| DOI | 10.3389/fimmu.2020.616141 |
| Web of Science KeyUT | 000616095500001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fimmu.2020.616141 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kikuoka, Ryo| Miyazaki, Ikuko| Kubota, Natsuki| Maeda, Megumi| Kagawa, Daiki| Moriyama, Masaaki| Sato, Asuka| Murakami, Shinki| Kitamura, Yoshihisa| Sendo, Toshiaki| Asanuma, Masato| |
| 発行日 | 2020-11-26 |
| 出版物タイトル | Scientific Reports |
| 巻 | 10巻 |
| 号 | 1号 |
| 出版者 | Nature Research |
| 開始ページ | 20698 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2020 |
| 論文のバージョン | publisher |
| PubMed ID | 33244123 |
| DOI | 10.1038/s41598-020-77652-4 |
| Web of Science KeyUT | 000596329600054 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-020-77652-4 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hirai, Kenta| Ousaka, Daiki| Fukushima, Yosuke| Kondo, Maiko| Eitoku, Takahiro| Shigemitsu, Yusuke| Hara, Mayuko| Baba, Kenji| Iwasaki, Tatsuo| Kasahara, Shingo| Ohtsuki, Shinichi| Oh, Hidemasa| |
| 備考 | This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Translational Medicine on 573(12), 2020, DOI: 10.1126/scitranslmed.abb3336.| |
| 発行日 | 2020-12-09 |
| 出版物タイトル | Science Translational Medicine |
| 巻 | 12巻 |
| 号 | 573号 |
| 出版者 | American Association for the Advancement of Science |
| 開始ページ | eabb3336 |
| ISSN | 1946-6234 |
| NCID | AA12519139 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Authors |
| 論文のバージョン | author |
| PubMed ID | 33298561 |
| DOI | 10.1126/scitranslmed.abb3336 |
| Web of Science KeyUT | 000597340700004 |
| 関連URL | isVersionOf https://doi.org/10.1126/scitranslmed.abb3336 |
| フルテキストURL | fulltext.pdf Suppl. Info.pdf Suppl. Tables.xlsx |
|---|---|
| 著者 | Morita, Takuya| Fujiwara, Tomohiro| Yoshida, Aki| Uotani, Koji| Kiyono, Masahiro| Yokoo, Suguru| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| キーワード | Sarcoma Translational research |
| 発行日 | 2020-06-10 |
| 出版物タイトル | Scientific Reports |
| 巻 | 10巻 |
| 号 | 1号 |
| 出版者 | Nature |
| 開始ページ | 9414 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2020 |
| 論文のバージョン | publisher |
| PubMed ID | 32523124 |
| DOI | 10.1038/s41598-020-66120-8 |
| Web of Science KeyUT | 000560478900030 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-020-66120-8 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Moh-Moh-Aung, Aye| Fujisawa, Masayoshi| Ito, Sachio| Katayama, Hiroshi| Ohara, Toshiaki| Ota, Yoko| Yoshimura, Teizo| Matsukawa, Akihiro| |
| キーワード | Molecular medicine Tumour angiogenesis |
| 発行日 | 2020-06-26 |
| 出版物タイトル | Scientific Reports |
| 巻 | 10巻 |
| 号 | 1号 |
| 出版者 | Nature |
| 開始ページ | 10418 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2020 |
| 論文のバージョン | publisher |
| PubMed ID | 32591615 |
| DOI | 10.1038/s41598-020-67425-4 |
| Web of Science KeyUT | 000545967200015 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-020-67425-4 |
| JaLCDOI | 10.18926/AMO/59948 |
|---|---|
| フルテキストURL | 74_3_185.pdf |
| 著者 | Sano, Toshikazu| Ishigami, Shuta| Ito, Tatsuo| Sano, Shunji| |
| 抄録 | Heart diseases are one of the major causes of morbidity and mortality worldwide. Despite major advances in drug and interventional therapies, surgical procedures, and organ transplantation, further research into new therapeutic options is still necessary. Stem cell therapy has emerged as one option for the treatment of a variety of heart diseases. Although a large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach, the results obtained from these clinical studies are inconsistent, and stem cell-based improvements of heart performance and cardiac remodeling were found to be quite limited. Since the precise mechanisms underlying the therapeutic actions of stem cells are still under debate, researchers have developed a variety of strategies to improve and boost the potency of stem cells in repair. In this review, we summarize both the current therapeutic strategies using stem cells and future directions for enhancing stem cell potency. |
| キーワード | heart disease stem cell myocardial regeneration |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-06 |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 185 |
| 終了ページ | 190 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32577015 |
| Web of Science KeyUT | 000543363400001 |
| NAID | 120006862790 |
| タイトル（別表記） | The 2017 Incentive Award of the Okayama Medical Association in General Medical Science (2017 Yuuki Prize) |
|---|---|
| フルテキストURL | 131_9.pdf |
| 著者 | 勝山 惠理| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2019-04-01 |
| 巻 | 131巻 |
| 号 | 1号 |
| 開始ページ | 9 |
| 終了ページ | 11 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.131.9 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2019 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.131.9 |
| NAID | 130007642647 |
| JaLCDOI | 10.18926/AMO/56930 |
|---|---|
| フルテキストURL | 73_4_285.pdf |
| 著者 | Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| 抄録 | Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion. |
| キーワード | glioma cytoskeletons invasion microtubules |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 285 |
| 終了ページ | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439951 |
| フルテキストURL | K0005922_abstract_review.pdf.pdf K0005922_summary.pdf.pdf |
|---|---|
| 著者 | 伏見 滋子| |
| 発行日 | 2019-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5922号 |
| 学位授与年月日 | 2019-03-25 |
| 学位・専攻分野 | 博士（歯学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| JaLCDOI | 10.18926/AMO/55857 |
|---|---|
| フルテキストURL | 72_2_165.pdf |
| 著者 | Yoshida, Aki| Fujiwara, Tomohiro| Uotani, Koji| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hasei, Joe| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| 抄録 | Although there is considerable evidence indicating that the dysregulation of microRNAs (miRNAs) in malignant tumors plays a role in tumor development, the overall function of miRNAs and their clinicopathological significance are not well understood. In this retrospective analysis of 45 biopsy specimens from osteosarcoma (OS) patients, we investigated the functional and clinical significance of miR-25-3p in OS, which we previously identified as a highly expressed miRNA in OS patients’ serum. We observed that miR-25-3p dysregulation in human OS tissues was negatively correlated with the clinical prognosis, whereas the expression level of its target gene, Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3), was positively correlated with the clinical prognosis. Endogenous miR-25-3p upregulation promoted tumor growth, invasion, and drug resistance, which was consistent with DKK3 silencing in OS cells. In addition, secretory miR-25-3p was embedded in tumor-derived exosomes, where it promoted capillary formation and the invasion of vascular endothelial cells. Overall, our results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in OS, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease. |
| キーワード | microRNA circulating microRNA osteosarcoma prognosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 165 |
| 終了ページ | 174 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674765 |