start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=1 article-no= start-page=140 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240422 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem cell transplantation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background Endoscopic features of intestinal transplant-associated microangiopathy (iTAM) have not been comprehensively investigated. This study aimed to examine the endoscopic characteristics of patients diagnosed with iTAM.
Methods This retrospective analysis included 14 patients pathologically diagnosed with iTAM after stem cell transplantation for hematolymphoid neoplasms (n = 13) or thalassemia (n = 1). The sex, age at diagnosis, endoscopic features, and prognosis of each patient were assessed. Serological markers for diagnosing transplant-associated thrombotic microangiopathy were also evaluated.
Results The mean age at the time of iTAM diagnosis was 40.2 years. Patients diagnosed based on the pathognomonic pathological changes of iTAM presented with diverse symptoms at the times of endoscopic examinations, including diarrhea (n = 10), abdominal pain (n = 5), nausea (n = 4), appetite loss (n = 2), bloody stools (n = 2), abdominal discomfort (n = 1), and vomiting (n = 1). At the final follow-up, six patients survived, while eight patients succumbed, with a median time of 100.5 days (range: 52-247) post-diagnosis. Endoscopic manifestations included erythematous mucosa (n = 14), erosions (n = 13), ulcers (n = 9), mucosal edema (n = 9), granular mucosa (n = 9), and villous atrophy (n = 4). Erosions and/or ulcers were primarily observed in the colon (10/14, 71%), followed by the ileum (9/13, 69%), stomach (4/10, 40%), cecum (5/14, 36%), duodenum (3/10, 30%), rectum (4/14, 29%), and esophagus (1/10, 10%). Cytomegalovirus infection (n = 4) and graft-versus-host disease (n = 2) coexisted within the gastrointestinal tract. Patients had de novo prolonged or progressive thrombocytopenia (6/14, 43%), decreased hemoglobin concentration (4/14, 29%), reduced serum haptoglobin level (3/14, 21%), and a sudden and persistent increase in lactate dehydrogenase level (2/14, 14%). Peripheral blood samples from 12 patients were evaluated for schistocytes, with none exceeding 4%.
Conclusions This study provides a comprehensive exploration of the endoscopic characteristics of iTAM. Notably, all patients exhibited erythematous mucosa throughout the gastrointestinal tract, accompanied by prevalent manifestations, such as erosions (93%), ulcers (64%), mucosal edema (64%), granular mucosa (64%), and villous atrophy (29%). Because of the low positivity for serological markers of transplant-associated thrombotic microangiopathy in patients with iTAM, endoscopic evaluation and biopsy of these lesions are crucial, even in the absence of these serological features. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EnnishiDaisuke en-aut-sei=Ennishi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiiNobuharu en-aut-sei=Fujii en-aut-mei=Nobuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsuokaKen-Ichi en-aut-sei=Matsuoka en-aut-mei=Ken-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Colonoscopy kn-keyword=Colonoscopy en-keyword=Esophagogastroduodenoscopy kn-keyword=Esophagogastroduodenoscopy en-keyword=Graft-versus-host disease kn-keyword=Graft-versus-host disease en-keyword=Hematopoietic stem cell transplantation kn-keyword=Hematopoietic stem cell transplantation en-keyword=Intestinal transplant-associated microangiopathy kn-keyword=Intestinal transplant-associated microangiopathy en-keyword=iTAM kn-keyword=iTAM END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=4 article-no= start-page=347 end-page=357 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Feasibility of Flow Cytometry Analysis of Gastrointestinal Tract-Residing Lymphocytes in Hematopoietic Stem Cell Transplant Recipients en-subtitle= kn-subtitle= en-abstract= kn-abstract=The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KondoTakumi en-aut-sei=Kondo en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=EnnishiDaisuke en-aut-sei=Ennishi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FujiiNobuharu en-aut-sei=Fujii en-aut-mei=Nobuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsuokaKen-ichi en-aut-sei=Matsuoka en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiTakahide en-aut-sei=Takahashi en-aut-mei=Takahide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HirabataAraki en-aut-sei=Hirabata en-aut-mei=Araki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Division of Medical Support, Okayama University Hospital kn-affil= affil-num=7 en-affil=Division of Medical Support, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=flow cytometry kn-keyword=flow cytometry en-keyword=stem cell transplantation kn-keyword=stem cell transplantation en-keyword=transplantation-associated microangiopathy kn-keyword=transplantation-associated microangiopathy END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=1 article-no= start-page=647 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical characteristics of Campylobacter bacteremia: a multicenter retrospective study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Campylobacter species are the pathogens of the intestinal tract, which infrequently cause bacteremia. To reveal the clinical characteristics of Campylobacter bacteremia, we performed a retrospective, multicenter study. Patients diagnosed with Campylobacter bacteremia in three general hospitals in western Japan between 2011 and 2021 were included in the study. Clinical, microbiological, and prognostic data of the patients were obtained from medical records. We stratified the cases into the gastroenteritis (GE) and fever predominant (FP) types by focusing on the presence of gastrointestinal symptoms. Thirty-nine patients (24 men and 15 women) were included, with a median age of 57 years and bimodal distribution between those in their 20 s and the elderly. The proportion of GE and FP types were 21 (53.8%) and 18 (46.2%), respectively. Comparing these two groups, there was no significant difference in patient backgrounds in terms of sex, age, and underlying diseases. Campylobacter jejuni was exclusively identified in the GE type (19 cases, 90.5%), although other species such as Campylobacter fetus and Campylobacter coli were isolated in the FP type as well. Patients with the FP type underwent intravenous antibiotic therapy more frequently (47.6% vs. 88.9%), and their treatment (median: 5 days vs. 13 days) and hospitalization (median: 7 days vs. 21 days) periods were significantly longer. None of the patients died during the hospitalization. In summary, we found that nearly half of the patients with Campylobacter bacteremia presented with fever as a predominant manifestation without gastroenteritis symptoms. en-copyright= kn-copyright= en-aut-name=OtsukaYuki en-aut-sei=Otsuka en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakahashiMisa en-aut-sei=Takahashi en-aut-mei=Misa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukushimaShinnosuke en-aut-sei=Fukushima en-aut-mei=Shinnosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MaedaRuri en-aut-sei=Maeda en-aut-mei=Ruri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SunadaNaruhiko en-aut-sei=Sunada en-aut-mei=Naruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamadaHaruto en-aut-sei=Yamada en-aut-mei=Haruto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KishidaMasayuki en-aut-sei=Kishida en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujitaKoji en-aut-sei=Fujita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Clinical Laboratory, Okayama City Hospital kn-affil= affil-num=8 en-affil=Department of General Internal Medicine, Okayama City Hospital kn-affil= affil-num=9 en-affil=Department of General Medicine and Infectious Disease, Tsuyama Chuo Hospital kn-affil= affil-num=10 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page=1132983 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230309 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impact of oral microbiota on pathophysiology of GVHD en-subtitle= kn-subtitle= en-abstract= kn-abstract=Allogeneic transplantation of hematopoietic cells is the only curative therapy for several hematopoietic disease in which patients receive cytotoxic conditioning regimens followed by infusion of hematopoietic stem cells. Although the outcomes have improved over the past decades, graft-versus-host-disease (GVHD), the most common life-threatening complication, remains a major cause of non-relapse morbidity and mortality. Pathophysiology of acute GVHD characterized by host antigen-presenting cells after tissue damage and donor T-cells is well studied, and additionally the importance of recipient microbiota in the intestine is elucidated in the GVHD setting. Oral microbiota is the second most abundant bacterial flora in the body after the intestinal tract, and it is related to chronic inflammation and carcinogenesis. Recently, composition of the oral microbiome in GVHD related to transplantation has been characterized and several common patterns, dysbiosis and enrichment of the specific bacterial groups, have been reported. This review focuses on the role of the oral microbiota in the context of GVHD. en-copyright= kn-copyright= en-aut-name=YamamotoAkira en-aut-sei=Yamamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KambaraYui en-aut-sei=Kambara en-aut-mei=Yui kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraHideaki en-aut-sei=Fujiwara en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Hematology and Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= en-keyword=oral microbiota kn-keyword=oral microbiota en-keyword=GvHD kn-keyword=GvHD en-keyword=dysbiosis kn-keyword=dysbiosis en-keyword=allogeneic transplantation of hematopoietic cells kn-keyword=allogeneic transplantation of hematopoietic cells en-keyword=prediction kn-keyword=prediction en-keyword=HSCT kn-keyword=HSCT END start-ver=1.4 cd-journal=joma no-vol=2022 cd-vols= no-issue= article-no= start-page=4635171 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220621 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=In Vivo Functional Assessment of Sodium-Glucose Cotransporters (SGLTs) Using [F-18]Me4FDG PET in Rats en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background. Mediating glucose absorption in the small intestine and renal clearance, sodium glucose cotransporters (SGLTs) have emerged as an attractive therapeutic target in diabetic patients. A substantial fraction of patients, however, only achieve inadequate glycemic control. Thus, we aimed to assess the potential of the SGLT-targeting PET radiotracer alpha-methyl-4-deoxy-4-[F-18]fluoro-D-glucopyranoside ([F-18]Me4FDG) as a noninvasive intestinal and renal biomarker of SGLT-mediated glucose transport. Methods. We investigated healthy rats using a dedicated small animal PET system. Dynamic imaging was conducted after administration of the reference radiotracer 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG), or the SGLT-targeting agent, [F-18]Me4FDG either directly into the digestive tract (for assessing intestinal absorption) or via the tail vein (for evaluating kidney excretion). To confirm the specificity of [F-18]Me4FDG and responsiveness to treatment, a subset of animals was also pretreated with the SGLT inhibitor phlorizin. In this regard, an intraintestinal route of administration was used to assess tracer absorption in the digestive tract, while for renal assessment, phlorizin was injected intravenously (IV). Results. Serving as reference, intestinal administration of [F-18]FDG led to slow absorption with retention of 89.2 +/- 3.5% of administered radioactivity at 15 min. [F-18]Me4FDG, however, was rapidly absorbed into the blood and cleared from the intestine within 15 min, leading to markedly lower tracer retention of 18.5 +/- 1.2% (P < 0.0001). Intraintestinal phlorizin led to marked increase of [F-18]Me4FDG uptake (15 min, 99.9 +/- 4.7%; P < 0.0001 vs. untreated controls), supporting the notion that this PET agent can measure adequate SGLT inhibition in the digestive tract. In the kidneys, radiotracer was also sensitive to SGLT inhibition. After IV injection, [F-18]Me4FDG reabsorption in the renal cortex was significantly suppressed by phlorizin when compared to untreated animals (%ID/g at 60 min, 0.42 +/- 0.10 vs. untreated controls, 1.20 +/- 0.03; P < 0.0001). Conclusion. As a noninvasive read-out of the concurrent SGLT expression in both the digestive tract and the renal cortex, [F-18]Me4FDG PET may serve as a surrogate marker for treatment response to SGLT inhibition. As such, [F-18]Me4FDG may enable improvement in glycemic control in diabetes by PET-based monitoring strategies. en-copyright= kn-copyright= en-aut-name=MatsusakaYohji en-aut-sei=Matsusaka en-aut-mei=Yohji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ChenXinyu en-aut-sei=Chen en-aut-mei=Xinyu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Arias-LozaPaula en-aut-sei=Arias-Loza en-aut-mei=Paula kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WernerRudolf A. en-aut-sei=Werner en-aut-mei=Rudolf A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NoseNaoko en-aut-sei=Nose en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SasakiTakanori en-aut-sei=Sasaki en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=RoweSteven P. en-aut-sei=Rowe en-aut-mei=Steven P. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=PomperMartin G. en-aut-sei=Pomper en-aut-mei=Martin G. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=LapaConstantin en-aut-sei=Lapa en-aut-mei=Constantin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HiguchiTakahiro en-aut-sei=Higuchi en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Nuclear Medicine and Comprehensive Heart Failure Center, University Hospital of W?rzburg kn-affil= affil-num=2 en-affil=Department of Nuclear Medicine and Comprehensive Heart Failure Center, University Hospital of W?rzburg kn-affil= affil-num=3 en-affil=Department of Nuclear Medicine and Comprehensive Heart Failure Center, University Hospital of W?rzburg kn-affil= affil-num=4 en-affil=Department of Nuclear Medicine and Comprehensive Heart Failure Center, University Hospital of W?rzburg kn-affil= affil-num=5 en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Division of Nuclear Medicine and Molecular Imaging, The Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine kn-affil= affil-num=8 en-affil=Division of Nuclear Medicine and Molecular Imaging, The Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine kn-affil= affil-num=9 en-affil= Nuclear Medicine, Faculty of Medicine, University of Augsburg kn-affil= affil-num=10 en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=2 article-no= start-page=155 end-page=165 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinicopathological Features and Surgical Outcomes of Small Bowel Metastasis from Renal Cell Carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Small bowel metastasis from renal cell carcinoma (RCC) is rare, and its clinicopathological characteristics are unclear; thus, we revisited the concept of this tumor and reviewed its diagnostic and treatment modalities. We filtered MEDLINE searches of articles published in English between 1950 and 2019, and identified 100 patients who had undergone treatment, including 1 patient from our clinic. We extracted patient characteristics, treatment, and prognostic data, resulting in clinicopathological data on 100 patients (83 men, 17 women). Mean age was 63 years (range, 16-86 years). Tumor sites were duodenum, jejunum, ileum, and multiple sites in 30, 37, 25, and 7 patients, respectively. The 1-, 3-, and 5-year overall survival rates after diagnosis were 53.0%, 36.0%, and 36.0%. Curative resection patients showed 62.1% 5-year survival after surgery, vs. 27.5% in noncurative surgical management cases. Good prognoses can be expected if these tumors are identified early for complete removal. Surgery is the only curative option. To determine the best management strategy and improve prognostic accuracy, we continue to collect and analyze epidemiological and pathological data. Although this condition is rare, surgery should be considered if curative resection is expected. Prognosis after curative resection is not poor, but recurrence is not unlikely. en-copyright= kn-copyright= en-aut-name=KimuraJiro en-aut-sei=Kimura en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkabayashiTakehiro en-aut-sei=Okabayashi en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuiKenta en-aut-sei=Sui en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TabuchiMotoyasu en-aut-sei=Tabuchi en-aut-mei=Motoyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IwataJun en-aut-sei=Iwata en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HataYasuhiro en-aut-sei=Hata en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IiyamaTatsuo en-aut-sei=Iiyama en-aut-mei=Tatsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OnoNoriaki en-aut-sei=Ono en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, National Center for Global Health and Medicine kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, National Center for Global Health and Medicine kn-affil= affil-num=3 en-affil=Department of Gastroenterological Surgery, National Center for Global Health and Medicine kn-affil= affil-num=4 en-affil=Department of Gastroenterological Surgery, National Center for Global Health and Medicine kn-affil= affil-num=5 en-affil=Department of Diagnostic Pathology, National Center for Global Health and Medicine kn-affil= affil-num=6 en-affil=Department of Radiology, National Center for Global Health and Medicine kn-affil= affil-num=7 en-affil=Department of Biostatistics, National Center for Global Health and Medicine kn-affil= affil-num=8 en-affil=Department of Urology, Kochi Health Sciences Center kn-affil= en-keyword=renal cell carcinoma kn-keyword=renal cell carcinoma en-keyword=small bowel metastasis kn-keyword=small bowel metastasis en-keyword=intestine kn-keyword=intestine en-keyword=tumor kn-keyword=tumor END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=22 article-no= start-page=5774 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211118 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches en-subtitle= kn-subtitle= en-abstract= kn-abstract=Simple Summary: It is challenging for pathologists to diagnose primary gastrointestinal T-cell neoplasms. Besides the rarity of the diseases, the small biopsy material makes it more difficult to differentiate between non-neoplastic inflammation and secondary involvement of extra gastrointestinal lymphoma. Since this group of diseases ranges from aggressive ones with a very poor prognosis to indolent ones that require caution to avoid overtreatment, the impact of the diagnosis on the patient is enormous. Although early treatment of aggressive lymphoma is essential, the treatment strategy is not well established, which is a problem for clinicians. This review provides a cross-sectional comparison of histological findings. Unlike previous reviews, we summarized up-to-date clinically relevant information including the treatment strategies as well as practical differential diagnosis based on thorough literature review.

Abstract: Primary gastrointestinal (GI) T-cell neoplasms are extremely rare heterogeneous disease entities with distinct clinicopathologic features. Given the different prognoses of various disease subtypes, clinicians and pathologists must be aware of the key characteristics of these neoplasms, despite their rarity. The two most common aggressive primary GI T-cell lymphomas are enteropathy-associated T-cell lymphoma and monomorphic epitheliotropic intestinal T-cell lymphoma. In addition, extranodal natural killer (NK)/T-cell lymphoma of the nasal type and anaplastic large cell lymphoma may also occur in the GI tract or involve it secondarily. In the revised 4th World Health Organization classification, indolent T-cell lymphoproliferative disorder of the GI tract has been incorporated as a provisional entity. In this review, we summarize up-to-date clinicopathological features of these disease entities, including the molecular characteristics of primary GI T-cell lymphomas and indolent lymphoproliferative disorders. We focus on the latest treatment approaches, which have not been summarized in existing reviews. Further, we provide a comprehensive review of available literature to address the following questions: How can pathologists discriminate subtypes with different clinical prognoses? How can primary GI neoplasms be distinguished from secondary involvement? How can these neoplasms be distinguished from non-specific inflammatory changes at an early stage? en-copyright= kn-copyright= en-aut-name=NishimuraMidori Filiz en-aut-sei=Nishimura en-aut-mei=Midori Filiz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimuraYoshito en-aut-sei=Nishimura en-aut-mei=Yoshito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishikoriAsami en-aut-sei=Nishikori en-aut-mei=Asami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoYasuharu en-aut-sei=Sato en-aut-mei=Yasuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Division of Pathophysiology, Okayama University Graduate School of Health Sciences kn-affil= affil-num=4 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=primary gastrointestinal T-cell lymphoma kn-keyword=primary gastrointestinal T-cell lymphoma en-keyword=enteropathy-associated T-cell lymphoma kn-keyword=enteropathy-associated T-cell lymphoma en-keyword=EATL kn-keyword=EATL en-keyword=monomorphic epitheliotropic intestinal T-cell lymphoma kn-keyword=monomorphic epitheliotropic intestinal T-cell lymphoma en-keyword=MEITL kn-keyword=MEITL en-keyword=indolent T-cell lymphoproliferative disorder kn-keyword=indolent T-cell lymphoproliferative disorder en-keyword=ITLPD-GI kn-keyword=ITLPD-GI en-keyword=NK-cell enteropathy kn-keyword=NK-cell enteropathy END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=663 end-page=667 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants. en-copyright= kn-copyright= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MaruyamaYuki en-aut-sei=Maruyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HiyamaYoshiki en-aut-sei=Hiyama en-aut-mei=Yoshiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitanoHiroyuki en-aut-sei=Kitano en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamadaHiroki en-aut-sei=Yamada en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GotoTakayuki en-aut-sei=Goto en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KondoTsubasa en-aut-sei=Kondo en-aut-mei=Tsubasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShigemuraKatsumi en-aut-sei=Shigemura en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MitsuiYosuke en-aut-sei=Mitsui en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IwataTakehiro en-aut-sei=Iwata en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=WatanabeMasami en-aut-sei=Watanabe en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=TakenakaTadasu en-aut-sei=Takenaka en-aut-mei=Tadasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TeishimaJun en-aut-sei=Teishima en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=MiyataYasuyoshi en-aut-sei=Miyata en-aut-mei=Yasuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=IshikawaKiyohito en-aut-sei=Ishikawa en-aut-mei=Kiyohito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TakaokaEi-Ichiro en-aut-sei=Takaoka en-aut-mei=Ei-Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=MiyazakiJun en-aut-sei=Miyazaki en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=TakahashiSatoshi en-aut-sei=Takahashi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=MasumoriNaoya en-aut-sei=Masumori en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=KiyotaHiroshi en-aut-sei=Kiyota en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=FujisawaMasato en-aut-sei=Fujisawa en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=YamamotoShingo en-aut-sei=Yamamoto en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=SakumaTakafumi en-aut-sei=Sakuma en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=KusumiNorihiro en-aut-sei=Kusumi en-aut-mei=Norihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= en-aut-name=IchikawaTakaharu en-aut-sei=Ichikawa en-aut-mei=Takaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=27 ORCID= en-aut-name=WatanabeToyohiko en-aut-sei=Watanabe en-aut-mei=Toyohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=28 ORCID= en-aut-name=NasuYoshitsugu en-aut-sei=Nasu en-aut-mei=Yoshitsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=29 ORCID= en-aut-name=TsugawaMasaya en-aut-sei=Tsugawa en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=30 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=31 ORCID= en-aut-name=WadaKoichiro en-aut-sei=Wada en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=32 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Hakodate Goryoukaku Hospital kn-affil= affil-num=4 en-affil=Hiroshima University Hospital kn-affil= affil-num=5 en-affil=Jikei University Katsushika Medical Center kn-affil= affil-num=6 en-affil=Kyoto University Hospital kn-affil= affil-num=7 en-affil=Nagasaki University Hospital kn-affil= affil-num=8 en-affil=Kobe University Hospital kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=12 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=14 en-affil=Japanese Red Cross Okayama Hospital kn-affil= affil-num=15 en-affil=Hiroshima University Hospital kn-affil= affil-num=16 en-affil=Nagasaki University Hospital kn-affil= affil-num=17 en-affil=Fujita Health University Hospital kn-affil= affil-num=18 en-affil=Internationla University of Health and Welfare Hospital kn-affil= affil-num=19 en-affil=Internationla University of Health and Welfare Hospital kn-affil= affil-num=20 en-affil=Sapporo Medical University Hospital kn-affil= affil-num=21 en-affil=Sapporo Medical University Hospital kn-affil= affil-num=22 en-affil=Jikei University Katsushika Medical Center kn-affil= affil-num=23 en-affil=Kobe University Hospital kn-affil= affil-num=24 en-affil=Hyogo College of Medicine College Hospital kn-affil= affil-num=25 en-affil=Okayama Medical Center kn-affil= affil-num=26 en-affil=Okayama Medical Center kn-affil= affil-num=27 en-affil=Okayama Medical Center kn-affil= affil-num=28 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=29 en-affil=Okayama Rosai Hospital kn-affil= affil-num=30 en-affil=Okayama City General Medical Center kn-affil= affil-num=31 en-affil=Department of Urology, Okayama University Hospital kn-affil= affil-num=32 en-affil=Department of Urology, Okayama University Hospital kn-affil= en-keyword=antibiotic prophylaxis kn-keyword=antibiotic prophylaxis en-keyword=selective culture media kn-keyword=selective culture media en-keyword=prostate biopsy kn-keyword=prostate biopsy en-keyword=fluoroquinolone-resistant kn-keyword=fluoroquinolone-resistant en-keyword=extended- spectrum beta-lactamase kn-keyword=extended- spectrum beta-lactamase END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=625 end-page=629 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Histologic Transformation from Follicular Lymphoma to Diffuse Large B-cell Lymphoma Detected during Colonoscopy en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 77-year-old Japanese woman who had been treated for follicular lymphoma for 8 years developed abdominal pain and intra-abdominal lymphadenopathies. Colonoscopy revealed an elevated lesion in the rectum, which presented as two humps with erosions. A diagnosis of histologic transformation of follicular lymphoma to diffuse large B-cell lymphoma was made by endoscopic biopsy. This case underscores the importance of endoscopy examinations and biopsy of newly emerged gastrointestinal lesions for the prompt diagnosis of histologic transformation, since salvage chemotherapy must be initiated quickly in such cases. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamasakiYasushi en-aut-sei=Yamasaki en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsadaNoboru en-aut-sei=Asada en-aut-mei=Noboru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsuokaKen-ichi en-aut-sei=Matsuoka en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=colorectal lymphoma kn-keyword=colorectal lymphoma en-keyword=follicular lymphoma kn-keyword=follicular lymphoma en-keyword=diffuse large B-cell lymphoma kn-keyword=diffuse large B-cell lymphoma en-keyword=histologic transformation kn-keyword=histologic transformation END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=549 end-page=556 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Glial Cells as Possible Targets of Neuroprotection through Neurotrophic and Antioxidative Molecules in the Central and Enteric Nervous Systems in Parkinson’s Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells. en-copyright= kn-copyright= en-aut-name=IsookaNami en-aut-sei=Isooka en-aut-mei=Nami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyazakiIkuko en-aut-sei=Miyazaki en-aut-mei=Ikuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AsanumaMasato en-aut-sei=Asanuma en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Parkinson’s disease kn-keyword=Parkinson’s disease en-keyword=astrocyte kn-keyword=astrocyte en-keyword=enteric glial cell kn-keyword=enteric glial cell en-keyword=neurotrophic factor kn-keyword=neurotrophic factor en-keyword=antioxidative molecule kn-keyword=antioxidative molecule END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=5 article-no= start-page=443 end-page=448 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Combined Laparoscopic and CT Monitoring of the Ice-Ball Margin during Cryoablation for Renal Cell Carcinoma Associated with von Hippel-Lindau Disease: First Case en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a 47-year-old Japanese female with 10 previous treatments for multiple bilateral renal cell carcinoma (RCC) associated with von Hippel-Lindau disease. The 14-mm right lower pole renal tumor was in contact with the right ureter. Laparoscopic cryoablation was performed to protect the ureter wrapped with gauze. Computed tomography (CT) monitoring was used to confirm the precise ? 6 mm ice-ball margin. There was no local progression at 6-months post-surgery. The serum creatinine has been stable. This is apparently the first report of combined laparoscopic and CT monitoring of an ice-ball formation and its margin during cryoablation for RCC. en-copyright= kn-copyright= en-aut-name=SekitoTakanori en-aut-sei=Sekito en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UkaMayu en-aut-sei=Uka en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KomakiToshiyuki en-aut-sei=Komaki en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsuiYusuke en-aut-sei=Matsui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IguchiToshihiro en-aut-sei=Iguchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KatayamaSatoshi en-aut-sei=Katayama en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WatariShogo en-aut-sei=Watari en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MaruyamaYuki en-aut-sei=Maruyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MitsuiYosuke en-aut-sei=Mitsui en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KubotaRisa en-aut-sei=Kubota en-aut-mei=Risa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=WadaKoichiro en-aut-sei=Wada en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=TakamotoAtsushi en-aut-sei=Takamoto en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=SakoTomoko en-aut-sei=Sako en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=WatanabeToyohiko en-aut-sei=Watanabe en-aut-mei=Toyohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=16 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=17 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=18 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=19 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=20 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=21 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=22 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=23 en-affil= Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=laparoscopic cryoablation kn-keyword=laparoscopic cryoablation en-keyword=multiple renal masses kn-keyword=multiple renal masses en-keyword=nephron-sparing surgery kn-keyword=nephron-sparing surgery en-keyword=renal cell carcinoma kn-keyword=renal cell carcinoma en-keyword=von Hippel-Lindau disease kn-keyword=von Hippel-Lindau disease END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4 article-no= start-page=265 end-page=274 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Factors Predicting a Favorable Disease Course Without Anti-TNF Therapy in Crohn’s Disease Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract=Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy. en-copyright= kn-copyright= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasutomiEriko en-aut-sei=Yasutomi en-aut-mei=Eriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkaShohei en-aut-sei=Oka en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamasakiYasushi en-aut-sei=Yamasaki en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KinugasaHideaki en-aut-sei=Kinugasa en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakaharMasahiro en-aut-sei=Takahar en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KatoJun en-aut-sei=Kato en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=bDepartment of Gastroenterology, Mitsui Memorial Hospital kn-affil= en-keyword=Crohn’s disease kn-keyword=Crohn’s disease en-keyword=anti-TNF agent kn-keyword=anti-TNF agent en-keyword=upper gastrointestinal lesion kn-keyword=upper gastrointestinal lesion en-keyword=bamboo joint-like appearance kn-keyword=bamboo joint-like appearance END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=1 article-no= start-page=23 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A20 (TNFAIP3) Alterations in Primary Intestinal Diffuse Large B-cell Lymphoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= The gastrointestinal (GI) tract is the most frequently involved site of extranodal non-Hodgkin lymphomas, and diffuse large B-cell lymphoma (DLBCL) is the most common subtype occurring in the GI tract. TNFAIP3 (A20) genetic alterations were reported to be involved in DLBCL’s pathogenesis and a portion of GI-DLBCL cases harbor this alteration. However, the frequency and clinicopathological relations focusing on small and large intestinal DLBCL are unclear. Here, we examined A20 deletion and protein expression and analyzed the clinicopathological features of 52 cases of primary intestinal DLBCL. The most frequently involved site was the ileocecal region (75%), followed by small bowel (13.5%) and large intestine. Immunohistochemically, the ileocecal cases expressed BCL6 (p=0.027) and MUM1 (p=0.0001) significantly more frequently than the small intestinal cases. Six of 47 cases (13%) had A20 heterozygous deletion, whereas all 6 heterozygously deleted cases had detectable A20 protein expression. In summary, A20 abnormality was less prevalent among intestinal DLBCLs with some discordancy between gene deletion and protein expression. Although the A20 alteration status did not affect any clinicopathological characteristics in this series, further studies exploring alterations of A20 and other NF-κB components in primary intestinal DLBCL are needed. en-copyright= kn-copyright= en-aut-name=FujiiaMasayoshi en-aut-sei=Fujiia en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakataKatsuyoshi en-aut-sei=Takata en-aut-mei=Katsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ChuangShih-Sung en-aut-sei=Chuang en-aut-mei=Shih-Sung kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Miyata-TakataTomoko en-aut-sei=Miyata-Takata en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AndoMidori en-aut-sei=Ando en-aut-mei=Midori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SatoYasuharu en-aut-sei=Sato en-aut-mei=Yasuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pathology, Chi-Mei Foundation Hospital kn-affil= affil-num=4 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pathology, Kagawa Prefectural Central Hospital kn-affil= affil-num=6 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=primary intestinal diffuse large B-cell lymphoma kn-keyword=primary intestinal diffuse large B-cell lymphoma en-keyword=cell of origin kn-keyword=cell of origin en-keyword=A20 kn-keyword=A20 en-keyword=TNFAIP3 kn-keyword=TNFAIP3 en-keyword=heterozygous deletion kn-keyword=heterozygous deletion END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=27 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Beh?et?s disease complicated by ileocecal and esophageal perforation kn-title=回盲部潰瘍穿孔，食道潰瘍穿孔をきたした腸管Beh?et 病の1 手術例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 36-year-old Japanese man known to have incomplete Beh?et’s disease (oral aphthous ulcers, genital ulcers, skin lesions, and esophageal and ileocecal ulcers) was admitted to our hospital in January 2011 for abdominal pain. We administered corticosteroids and immunosuppressants. Two months later, we performed an ileocecal resection to control gastrointestinal bleeding from the ileocecal ulcers. High fever persisted after this surgery, and upper gastrointestinal endoscopy demonstrated ulcer penetration between the lower and abdominal esophagus. Eighteen days after the initial ileocecal resection, we performed a lower esophagus resection, gastric tube reconstruction and enterostomy, during which we confirmed a 5-mm-dia. perforated site at the posterior wall of the abdominal esophagus. Postoperative anastomotic leakage and empyema occurred, but they were relieved by thoracic drainage and empyema dissection. en-copyright= kn-copyright= en-aut-name=TsukumoYuta en-aut-sei=Tsukumo en-aut-mei=Yuta kn-aut-name=九十九悠太 kn-aut-sei=九十九 kn-aut-mei=悠太 aut-affil-num=1 ORCID= en-aut-name=KawamotoKazuyuki en-aut-sei=Kawamoto en-aut-mei=Kazuyuki kn-aut-name=河本和幸 kn-aut-sei=河本 kn-aut-mei=和幸 aut-affil-num=2 ORCID= en-aut-name=TakagiKosei en-aut-sei=Takagi en-aut-mei=Kosei kn-aut-name=高木弘誠 kn-aut-sei=高木 kn-aut-mei=弘誠 aut-affil-num=3 ORCID= en-aut-name=ChinKai en-aut-sei=Chin en-aut-mei=Kai kn-aut-name=陳開 kn-aut-sei=陳 kn-aut-mei=開 aut-affil-num=4 ORCID= en-aut-name=MatsubaYuri en-aut-sei=Matsuba en-aut-mei=Yuri kn-aut-name=松葉優里 kn-aut-sei=松葉 kn-aut-mei=優里 aut-affil-num=5 ORCID= en-aut-name=NagahisaYoshio en-aut-sei=Nagahisa en-aut-mei=Yoshio kn-aut-name=長久吉雄 kn-aut-sei=長久 kn-aut-mei=吉雄 aut-affil-num=6 ORCID= en-aut-name=OkabeMichio en-aut-sei=Okabe en-aut-mei=Michio kn-aut-name=岡部道雄 kn-aut-sei=岡部 kn-aut-mei=道雄 aut-affil-num=7 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=8 ORCID= en-aut-name=ItohTadashi en-aut-sei=Itoh en-aut-mei=Tadashi kn-aut-name=伊藤雅 kn-aut-sei=伊藤 kn-aut-mei=雅 aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=4 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=5 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=6 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=7 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=9 en-affil= kn-affil=倉敷中央病院　消化器外科 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 en-keyword=ベーチェット病（Beh?et’s disease） kn-keyword=ベーチェット病（Beh?et’s disease） en-keyword=食道（esophagus） kn-keyword=食道（esophagus） en-keyword=回盲部（ileocecal） kn-keyword=回盲部（ileocecal） en-keyword=穿孔（perforation） kn-keyword=穿孔（perforation） en-keyword=手術（surgery） kn-keyword=手術（surgery） END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=7 article-no= start-page=1756 end-page=1770 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On traumatic Subcutaneous Injury of Gastro-entro Tracts kn-title=外傷性皮下腸管斷裂症ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the last few years, accidental injuries have greatly increased as a result of the progress of the mechanisation of urban industry. Recently I observed the cases of two patients suffering from unusual subcutaneous intestinal injuries caused by similar accidents. They had been caught in machines by their sleeves and belts, so that the latter which were made of leather severely squeezed their loins. Both patients were labouring men, strong, healthy and young and had climbed up to oil their machines when they were accidentally caught in the mechanism and saved themselves only by desperate efforts. One of them tore off the belt by himself and just managed to get down and was brought to our clinic. The other hung on and called out to his mates to stop the machine and was then brought down and carried by them to our clinic. The first case, aged 37, was seen six hours after the accident, when internal hemorrhage and peritonitis, caused by ruptured intestines were diagnosed. An operation was performed and it was found that the abdominal cavity was full of blood with a little gas while the jejunal tract was sharply amputated at a point 40cms. from the duodenojejunal flexure, and its mesentery was torn right up to the radix mesenterii, and was bleeding freely from the bottom; the serosa of ileum was torn in two places, about 20cms. from the ileocaecal valve and the serosa and mucosa of the caecum and the descending colon were also torn for about 5cms.; two retroperitoneal haematoma were found but no connection with any other organs could be found. Unfortunately the patient died seven days after the operation, as a result of general complications, in spite of every precaution. The second case, aged 26, was examined and subcutaneous rupture of the intestinal tract was diagnosed and an operation performed several hours later. To our surprise, three pieces of the Ushaped loops of the ileum, each about 10cms. long, were cut off sharply, as thouth amputated with a knife, at points 1 metre distant from the ileocaecal valve. The serosa of the sigmoid flexure was also torn in three places, each rupture being about 4 to 5cms. long. The post operative convalesence was uneventful. According to established theory, subcutaneous injuries of the gastro-entero tracts are classified as contusion, rupture and avulsion, which last is caused by pulling action. But in these observations and after experimental investigations with animals, I have come to the conclusion that traction cannot always effect the tearing off of the intestinal tract, which has very great extensibility and it is almost impossible to exert tractive action upon it, as it is with minor exceptions, quite free in the abdominal cavity. On the other hand, if compressive and frictional action be exerted on the tract against the hard vertebral column or ileacal bone, it may be easily amputated, as has been shown in my experiments with animals. In these cases, the patients struggled with the desperate efforts of powerful young men, to extricate themselves from the moving machines, which squeezed their loins by the strong leather belts, and this must have caused, in the second case, the several rows of U-shaped loops of gut to be intersected in the middle by the action of friction and compression between the belt and vertebral column, so that they were amputated into three pieces about 10cms. long. (See Fig. 2). In the first case, the amputation of the jeual tract may have been caused by the same thing. I therefore conclude that it would be better to call this, “traumatic subcutaneous amputation of the intestinal tract” rather than “traumatic subcutaneous avulsion of the intestinal tract”. en-copyright= kn-copyright= en-aut-name=HiraideShozo en-aut-sei=Hiraide en-aut-mei=Shozo kn-aut-name=平井出正三 kn-aut-sei=平井出 kn-aut-mei=正三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=10-1 article-no= start-page=6657 end-page=6667 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immuno-histological Studies on Hepatitis Part 3. A Study on the Pathogenesis of the So-called Hapatitic Cholecystopathy kn-title=肝炎に関する免疫組織学的研究 第3編 いわゆる肝炎性胆のう症の発生病理に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the cases of infectious hepatitis that has a complication of cholecystopathy, the author studied mainly its pathogenesis; and obtained the following results. 1. Out of 138 cases with hepatitis 33 cases (23.9%) had cholecystopathy as the complication. When these 33 cases are studied histologically by liver biopsy, periacinar form of chronic infectious hepatitis is found in 13 cases (39.3%), occupying the greatest percentage; followed by acute infectious hepatitis in 5 cases (15.2%), parenchymatous form of chronic infectious hepatitis in 4 (12.1%), posthepatitic cirrhosis in 4 (12.1%); and posthepatitic fibrosis in 2 (6.1%). On the other hand, judging cholecystopathy from various patho-histological forms, cholangiolitic hepatitis in 100%; periacinar form of chronic infectious hepatitis in 43.3%; posthepatitic fibrosis in 28.6%; parenchymatous form of chronic infectious hepatitis in 20%; posthepatitic cirrhosis in 11.9%; and acute infectious hepatitis in 11.8%. 2. Those showing biliary dyskinesia are mainly composed of the form revealing no marked changes in the liver biopsy (so-called posthepatitis syndrome) or the periacinar form of chronic infectious hepatitis. 3. Those having the complication of cholecystitis are more frequently found in acute infectious hepatitis and posthepatitic cirrhosis. 4. Generally even in the liver biopsy at the time of operation the infiltration of round cells and edema formation in portal region are characteristic traits of the common cholecystitis. 5. In the necropsy of infectious hepatitis likewise the liver and gallbladder are affected simultaneously; and the edema formation from the sublayer of mucous membrane to the sublayer of serous membrane and the congestion of capillary blood vessels with cell infiltration are the main common histological changes in the gallbladder. 6. When the antiserum obtained from the rabbit sensitized with dog abdominal organs (liver, gallbladder, duodenum, stomach, and rectal mucous membrane) as the antigen is injected into dogs, allergic cholecystitis can be induced in 100% of the animals with the use of gallbladder antiserum; in 80% with liver antiserum; in 60% with antiserum of rectal mucous membrane; and in 40% each with stomach antiserum or with antiserum of duodenal mucous membrane. In these instances intralobular and portal cell infiltration and edema formation in portal region can also be observed. 7. The characteristic traits of hepatitic cholecystopathy are the edema formation extending from the sublayer of the gallbladder mucous membrane to the sublayer of serous membrane and cell infiltration around blood vessels. As for the pathogenesis there seems to multiple factors; namely, dyscholia due to functional disturbances of the liver, the loss of the gallbladder motility due to invasion of inflammation inducing substances from portal tract through lymph ducts on serous inflammation, and also it is possible to be met with the secondary infection with an increase in the number of intestinal bacteria coexisting, and in some the involvement of allergic inflammation in gallbladder can be recognized. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=7-1 article-no= start-page=3955 end-page=3966 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Iron-Copper Metabolism in Idiopathic Hypochromic Anemia Part 2. Influence of the serum of idiopathic hypochromic anemia kn-title=本態性萎黄貧血に於ける鉄・銅代謝に関する研究 第2編 本症患者血清が家兎の鉄・銅代謝に及ぼす影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the present experiment the author studied the influences of the serum obtained from patients with idiopathic hypochromic anemia on the iron-copper metabolism of rabbits, and obtained the following results. 1. By successive injections of the serum of this disease no change occurs in the number of erythrocytes of rabbits, but the hemoglobin content decreases somewhat. Serum iron is moderately decreased while serum copper is slightly or moderately increased. 2. As for the non-hemin iron content in the viscera of the rabbit given successive injections of the serum of this disease, it tends to decrease in the liver and spleen, but it is markedly inceased in duodenum while it shows a tendency to increase slightly in the bone marrow. These findings seem to suggest that there are the acceleration in the hematopoietic function of bone marrow and the disturbance in the iron absorption via the intestinal tract. 3. As for the copper content in the viscera of the rabbit successively administered the serum of this disease, it is markedly increased in the liver; slightly increased in the kidneys; but it shows no great change in the spleen, bone marrow and duodenum. 4. The bone marrow picture of the rabbit receiving successive injections of the serum of this disease clearly shows the acceleration of hematopoietic function. From these findings it can be deduced that in the serum of this disease there exist factors that induce the acceleration of the bone marrow hematopoietic function, namely, the factor accelerating the iron consumption and impeding the iron absorption from the intestinal tract, and that these two factors are involved in inducing this disease. en-copyright= kn-copyright= en-aut-name=OkumuraKazutoshi en-aut-sei=Okumura en-aut-mei=Kazutoshi kn-aut-name=奥村一敏 kn-aut-sei=奥村 kn-aut-mei=一敏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=5 article-no= start-page=431 end-page=440 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=198310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Early gastric cancer and its complications: bleeding, perforation and pyloric stenosis. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Some cases of early gastric cancer are accompanied with complications of the upper gastro-intestinal tract. The characteristics of these complications were investigated, and the problems of diagnosis and treatment were discussed. Out of 297 cases of early gastric cancer, 18 cases were accompanied with complications of the upper gastro-intestinal tract, including 11 cases of bleeding, a case of perforation and 6 cases of pyloric stenosis. All 18 cases were of the macroscopically depressed type, and about 85 percent of the 297 early gastric cancer cases were of the depressed type. The depressed lesions were often accompanied by ulceration which was an important factor causing the complications, and the mechanism of which appeared to be the same as that of a benign ulcer. There are some cases of early gastric cancer which are discovered by their complications, and it would be more difficult to find an early gastric cancer lesion if there were a benign lesion at the same time. Therefore, it is necessary to take much care when diagnosing and treating cases which have such complications. An endoscopic examination before the operation is especially important, and a biopsy is indispensable.

en-copyright= kn-copyright= en-aut-name=ItanoSatoshi en-aut-sei=Itano en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=early gasric cancer kn-keyword=early gasric cancer en-keyword=complication kn-keyword=complication en-keyword=bleeding kn-keyword=bleeding en-keyword=perforation kn-keyword=perforation en-keyword=pyloric stenosis kn-keyword=pyloric stenosis END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=2 article-no= start-page=69 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=200204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Experimental models of small intestinal transplantation in rats: orthotopic versus heterotopic model. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Two kinds of surgical models of small intestinal transplantation (SITx) in rats, namely heterotopic (HIT) and orthotopic transplantion (OIT), have been reviewed. In OIT, the small intestine of the recipient is removed and the transplanted intestine replaces it in continuity. On the other hand, in the HIT model, the small intestinal grafts are rendered dysfunctional without alimentary tract continuity. Histological evidence showed that acute rejection appeared earlier in HIT as compared to OIT. Hyperplasia and hypertrophy of the muscularis externa produced in the chronic rejection process were more pronounced in HIT allografts. The HIT grafts showed severe mucosal atrophy due to the lack of intraluminal trophic factors, because oral feedings can stimulate tropic hormones for mucosal growth, and provide nutrients for enterocytes. Intestinal permeability was consistently higher after HIT than after OIT. The HIT grafts demonstrated less contractility and less response to chemical stimulation than did OIT grafts. The OIT models are advantageous in studies of intraluminal nutrients, and intestinal secretions in these models might modulate the intestinal immune status and possibly delay rejection. The superior intestinal barrier function and the delayed onset of rejection in OIT rats suggest that nutrients and other factors in the succus entericus are important for the maintenance of intestinal graft function.

en-copyright= kn-copyright= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaharaKazunori en-aut-sei=Tahara en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InoueSeichiro en-aut-sei=Inoue en-aut-mei=Seichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KobayashiEiji en-aut-sei=Kobayashi en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Jichi Medical School affil-num=2 en-affil= kn-affil=Jichi Medical School affil-num=3 en-affil= kn-affil=Jichi Medical School affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Jichi Medical School en-keyword=small intestinal transplantation kn-keyword=small intestinal transplantation en-keyword=rat kn-keyword=rat en-keyword=experimental model kn-keyword=experimental model en-keyword=orthotopic kn-keyword=orthotopic en-keyword=heterotopic kn-keyword=heterotopic END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue= article-no= start-page=25 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of a family with Peutz-Jeghers syndrome kn-title=Peutz-Jeghers症候群の1家系 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 58-year-old female was admitted because of colicky abdominal pain. Physical examination revealed firm abdominal wall, increased bowel sounds and multiple pigmented macules on the lips, oral mucosa, soles and volar aspects of the fingers and toes. Hyperventilation and tetanic rigidity of the extremities were also noted. The symptoms were successfully treated by intravenous injection of butropium bromide and diazepam. Roentgenological and fiberscopic examination revealed multiple polyps in the stomach, small intestine and colon ; the small intestine was most heavily loaded with polyps. Biopsy specimen revealed only inflammatory changes. The patient had undergone a resectien of the terminal ileum with polyps 15 years previously because of ileo-ileal intussusception. Histological re-evaluation of the polyp showed an actively proliferating papillary adenoma. The characteristic history and gastrointestinal findings lead us to the examination of the family, which revealed that her father, son and grandson had similar pigmentation of the skin and polyps in the gastrointestinal tract. These characteristic findings and family history permitted us to make a diagnosis of Peutz-Jeghers syndrome. The diagnosis had been missed supposedly because of unawareness of the skin lesions and the lack of hamartoma-like findings in the polyp. The tetanic rigidity of the extremities was probably hyperventilation syndrome induced by severe abdominal pain. The patient has been followed up for possible recurrence of symptoms and a potential malignant change. en-copyright= kn-copyright= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=KawabataKenji en-aut-sei=Kawabata en-aut-mei=Kenji kn-aut-name=川端健二 kn-aut-sei=川端 kn-aut-mei=健二 aut-affil-num=3 ORCID= en-aut-name=ShibataTsuneo en-aut-sei=Shibata en-aut-mei=Tsuneo kn-aut-name=柴田凡夫 kn-aut-sei=柴田 kn-aut-mei=凡夫 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所温泉内科学部門 affil-num=3 en-affil= kn-affil=岡山大学医学部第2病理 affil-num=4 en-affil= kn-affil=湯原町立湯原温泉病院 END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=8-9 article-no= start-page=679 end-page=683 dt-received= dt-revised= dt-accepted= dt-pub-year=1962 dt-pub=19620930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on disturibution of kn-title=縮瞳物質Corninの体内分布について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Experiments were performed to examine the disturibution of Cornin on the organs in the rabbit. 1) Cornin was demonstrable in all segments of digestive tract. Relatively little Cornin was found in extracts of oesophagus and considerable amounts of Cornin in stomach. The intestine contained large amounts of Cornin. 2) All parts of the central nervous system contained Cornin. The large amounts were found in the hypothalamus and corpus quadrigeminus, whereas extracts of the telencephalon showed little. 3) In adition to the digestive tract, other smooth muscle organs such as uterus, urinary bladder contained Cornin, although only in minute amounts. Other organs contained little amounts of Cornin. en-copyright= kn-copyright= en-aut-name=TokumotoHiroyosi en-aut-sei=Tokumoto en-aut-mei=Hiroyosi kn-aut-name=得本博允 kn-aut-sei=得本 kn-aut-mei=博允 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一生理学教室 END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=5-6 article-no= start-page=917 end-page=929 dt-received= dt-revised= dt-accepted= dt-pub-year=1965 dt-pub=19650630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histopathological Studies on Biopsy Specimens of Duodenal Mucosa in Chronic Hepatitis and Liver Cirrhosis 1. Histopathological evaluations of the duodenal mucosa in liver diseases with special reference to chronic hepatitis and liver cirrhosis kn-title=慢性肝炎並びに肝硬変症における十二指腸粘膜生検組織の病理組織学的研究第1編 慢性肝炎並びに肝硬変症を中心とした肝疾患の十二指腸粘膜の計測値について en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of clarifying the pathological conditions of the intestinal tract in liver diseases, histopathological examinations were conducted with the biopsy specimens of mucosa from 10 cases of chronic hepatitis and 10 cases of liver cirrhosis with the use of multipurpose suction biopsy tube (Brandborg, L, L. and Rubin, C. E.). The biopsy was made in the early morning at the time of empty stomach and the specimens were taken from the duodenum (third part) by oral suction biopsy under fluoroscopic view. In order to cut down the contraction to minimum, the specimens were fixed for 24 hours in 10 % formalin solution mixed with physiological saline solution kept at 4℃, and then the specimens were washed for three hours with tap water and embedded in paraffin in the routine manner. Abont 10 serial sections were prepared for each staining. Hematoxylin-eosin, Azan blue, a modified method Bielschowsky silver impregnation Pap. Van Gieson's stain and PAS-Schiff reaction were emplolyed for histopathological observations. In addition, about 100 serial sections of 15μ in thickness were prepared for each case and these were stained with hematoxylin-eosin for the reconstruction model of the mucosa to observe three dimensional aspects of mucosa. With this reconstruction model, the width of villi, the thickness of grandular layer and the mucosal surface area were measured. For the height of villi the distance from the plane of muscularis mucosae to the tip of villi was taken; the widest part of villi in the serial sections was taken for the width of villi; the thickness of lamina propria exclusive of villi on muscularis mucosae was taken as the thickness of grandular layer; and the surface area of mucosal epithelium per 1mm(2) of muscularis mucosae was also measured. The rcsults of these observations are briefly summarized in the following. 1. The height of villi in the chronic hepatitis group (500±4.3μ) did not show any significant difference from that (487±4.9μ) of normal control group, but that (447±5.2μ) in the liver cirrhosis group revealed a significant decrease, and this decreasing tendency was in the order of chronic hepatitis and liver cirrhosis. 2. As for the width of villi, there was no significant difference between normal control (140±3.6μ) and chronic hepatitis (143±3.2μ), but there was an increase in the liver cirrhosis group (162±3.7μ). 3. The thickness of grandular layer in the chronic hepatitis group (149±1.6μ) was increased as compared with normal control (142±1.8μ), whereas in the liver cirrhosis group (136±1.8μ) it was markedly decreased. This decreasing tendency was observed in the order of chronie hepatitis and liver cirrhosis, revealing that the decrease tends to become proportionately marked with advance in chronic state. 4. As for the surface area of mucosal epithelinm there was no significant difference between normal control (7.8±0.05mm(2)) and acute hpatitis group (7.2±0.20mm(2)), while it was decreased in the chronic hepatitis group (7.3±0.09mm(2)) and liver cirrhosis group (6.6±0.25mm(2)), and this decrease in the surface area was especially marked in five out of the ten cases of liver cirrhosis. This implies that along with the decrease in the surface area of mucosal epithelium in liver cirrhosis the swelling of spleen and the disturbances of absorption-function tend to aggravate. 5. Although histopathological pictures of the duodenal mucosa showed no marked changes in chronic hepatitis, in liver cirrhosis there were recognized such atrophic processes as fusion and atrophy of villi, fibrosis of tunica propria, the proliferation of reticular fibers and the degeneration and disappearance of Lieberkuhn's gland. en-copyright= kn-copyright= en-aut-name=AkagiEmile en-aut-sei=Akagi en-aut-mei=Emile kn-aut-name=赤木笑入 kn-aut-sei=赤木 kn-aut-mei=笑入 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=5-6 article-no= start-page=589 end-page=598 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on bile pigment Part 2. Intestinal absorption of bilirubin sulfate kn-title=胆汁色素に関する研究 第2編 硫酸抱合型bilirubinの腸管吸収に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Intestinal absorption of direct bilirubin was studied with chemically synthetic (3)H-bilirubin sulfate which was alkali-stable, and compared to that of commercial (3)H-bilirubin. (3)H-bilirubin sulfate and (3)H-bilirubin was loaded into three isolated intestinal segments, that is, the (isolated) duodenal segment, the (isolated) small intestinal segment and the (isolated) large intestinal segment of heterozygous Gunn rats and Wistar strain rats. After loading of bilirubins, biles and urines were collected at intervals of 2 hours up to 8 and from 8 to 24 hours. Radioactivity of the excreted biles and urines was studied and resulted as follows: 1) After loading of (3)H-bilirubin sulfate dissolved in physiological saline into the three each segment of Gunn rats or Wistar strain rats, ratios of the excreted radioactivity into bile were not significantly different between them. 2) After (3)H-bilirubin sulfate was dissolved in pool rat bile or physiological saline, the two each sample was loaded into the three each segment of Gunn rats. The difference of the excreted ratio was not significant between them. 3) In case of loading of (3)H-bilirubin sulfate into the small intestinal segment and the large intestinal segment in comparison of the duodenal segment, the ratio of excreted radioactivity into the bile was higher. 4) After (3)H-bilirubin sulfate or (3)H-bilirubin was dissolved in pool rat bile, the sample was loaded into the three each segment of Wistar strain rats. The biliary excretion within 24 hours following the loading of (3)H-bilirubin sulfate into the duodenal, small intestinal and large intestinal segment were 2.58, 4.41 and 4.33%, and loading (3)H-bilirubin, were 8.55, 7.35 and 3.70%, respectively. Difference between the excretion ratio of (3)H-bilirubin sulfate loading group and (3)H-bilirubin loading group was significant when loaded into the duodenal and small intestinal segment. But there was no difference between the excretion ratio of (3)H-bilirubin sulfate loading and (3)H-bilirubin loading into the large intestinal segment. 5) It was suggested that (3)H-bilirubin sulfate was absorbed from intestinal mucosa and excreted into biliary tract without any change of its nature. en-copyright= kn-copyright= en-aut-name=NakamuraNorio en-aut-sei=Nakamura en-aut-mei=Norio kn-aut-name=中村教夫 kn-aut-sei=中村 kn-aut-mei=教夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=9-10 article-no= start-page=1329 end-page=1357 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19771030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A cytochemical study of the absorption of horseradish peroxidase through the human gastrointestinal tract kn-title=ヒト消化管からのHorseradish Peroxidaseの吸収の細胞化学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using horseradish peroxidase (HRP) which serves as its own tracers, the absorption of intact macromolecules through the human gastrointestinal tracts was observed. In healthy volunteers, HRP was poured into the stomach, the duodenum, and the ileum through the gastric, duodenal and colonofiberscopes at several days interval. Twenty minutes after the injection, small samples of mucosa were removed. The tissues thus obtained were treated in the manner of Karnovsky and embedded in Epon and observed under an electron microscope. The absorption of HRP through the human small intestine and the intestinal metaplastic epithelia of the stomach was clearly demonstrated. Moreover, in intestinalized epithelium of the stomach, HRP was absorbed and transferred into the capillary lumen. These results indicated the posibility of absorption of macromolecules through the human gastrointestinal tract, which may be a cause of food-allergy and food poisoning. At the same time, it showed the effectiveness of oral administration of some enzyme-containing medicines. The absorption through the intestinal metaplastic epithelium was considered to be especially significant, because eaten proteins are promptly absorbed before digestion occurred. en-copyright= kn-copyright= en-aut-name=MatsumotoTeruo en-aut-sei=Matsumoto en-aut-mei=Teruo kn-aut-name=松本昭郎 kn-aut-sei=松本 kn-aut-mei=昭郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=9-10 article-no= start-page=1041 end-page=1051 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19831030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=BCG and Levamisole immunotherapies for peritoneal dissemination kn-title=腹膜播種に対するBCG. Levamisole免疫療法 en-subtitle= kn-subtitle= en-abstract= kn-abstract=BCG and levamisole (LMS) immunotherapies were applied to an experimental model of cancer in the digestive organs by considering the abdominal wall as the intestinal tract wall. Ehrlich ascites tumor cells transplanted subcutaneously into the abdominal wall of mice invaded to the parietal peritoneum in approximately two weeks. Afterwards the tumor cells appeared in the peritoneal cavity, following retention of ascites. Almost all tumor bearing mice died within three weeks after the appearance of tumor cells in the peritoneal cavity. Presensitized BCG showed significant suppressive effects on tumor growth compared with the control in tumor diameter and mean survival, but in the groups administered BCG after tumor transplantation and those administered BCG before and after tumor transplantation, there were no significant regressive effects. In two groups of mice administered BCG before tumor transplantation, the appearance of tumor cells in the peritoneal cavity was delayed. LMS administrated 3 days before tumor transplantation did not show any effects. In two groups administered LMS after tumor transplantation, LMS showed some effects, but with no significant difference in any parameters. In the group administered LMS 14 days after tumor transplantation, the appearance of tumor cells in the peritoneal cavity was delayed. BCG was probably superior to LMS administered before tumor transplantation, though the timing of the administration was questionable. LMS seemed to be effective even 14 days after tumor transplantation. en-copyright= kn-copyright= en-aut-name=KobayashiSeiji en-aut-sei=Kobayashi en-aut-mei=Seiji kn-aut-name=小林征二 kn-aut-sei=小林 kn-aut-mei=征二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=消化器癌 kn-keyword=消化器癌 en-keyword=腹膜浸潤 kn-keyword=腹膜浸潤 en-keyword=腹膜播種 kn-keyword=腹膜播種 en-keyword=BCG kn-keyword=BCG en-keyword=LMS kn-keyword=LMS END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=663 end-page=675 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organization of the reticular network of rabbit palatine tonsils kn-title=ウサギの口蓋扁桃における細網線維構築 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The collagen fiber network of rabbit palatine tonsils was studied by scanning electron microscopy (SEM) of alkali-water macerated tissues. Tissue sections adjacent to the SEM specimens were also observed by light microscopy. The collagen fibers, which consisted of collagen fibrils, branched out or fused together, thus forming the collagen networks as a whole. The collagen networks within the follicles were coarse, while those within the interfollicular areas were dense. The interfolliculae area that surrounded or was adjacent to the follicle had dense networks arranged in a concentric pattern around the follicles. Such a dense collagen network may be the site in which lymphocytes actively migrate. In the interfollicular area, there were high endothelial venules (HEVs) and lymphatic vessels which were surrounded by collagen sheaths. These venules and lymphatic vessels had many pores through which the lymphocytes appeared to migrate. Transmission electron microscopy of lead-stained tissue samples showed that the reticular fibers were closely associated with the thin cytoplasmic processes of the reticular cells. These processes were in direct contanct with the lymphocytes and had many pores or fenestrae. en-copyright= kn-copyright= en-aut-name=YamaneTatsuo en-aut-sei=Yamane en-aut-mei=Tatsuo kn-aut-name=山根辰生 kn-aut-sei=山根 kn-aut-mei=辰生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 en-keyword=扁桃 kn-keyword=扁桃 en-keyword=細網線維 kn-keyword=細網線維 en-keyword=コラーゲン線維 kn-keyword=コラーゲン線維 en-keyword=ウサギ kn-keyword=ウサギ en-keyword=低温アルカリ消化・走査電子顕微鏡法 kn-keyword=低温アルカリ消化・走査電子顕微鏡法 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=129 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Neurophysiological study of deep brain stimulation for the treatment of deafferentation pain Part 1. Influence of neurotransmitters upon deafferentation hyperactivity in cats -Participation of GABA in the descending inhibitory system- kn-title=Deafferentation pain に対する脳深部刺激療法の研究 第1編― Deafferentation hyperactivity に対する神経伝達物質の影響及び下行性抑制系との関係について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Deafferentation hyperactivity (DH) was provoked in the neurons of the subnucleus caudalis of the spinal trigeminal nucleus and the lateral reticular formation in cats by Gasserian ganglionectomy, and was used as a model of peripheral deafferentation pain. The influence of neurochemical substances upon DH was investigated. Neurotransmitters and their antagonists were applied topically around the soma of hyperactive neruons by the microiontophoretic technique, using a 7-barreled glass micropipette. Then the participation of inhibitory amino acids in the descending inhibitory systems, which were activated by deep brain stimulation (DBS), was investigated. Discharges of hyperactive neurons (n=75) were recorded extracellularly and analyzed using a spike density histogram. DH was suppressed by topically injected GABA and glycine, but not by met-enkephalin. The suppressive effects of GABA and glycine were almost completely antagonized by bicuculline and strychnine, respectively. Stimulation of the internal capsule or VPM suppressed DH, and this suppression was not affected by microiontophoretically injected bicuculline or strychnine. Intravenous injection of picrotoxin reduced the suppression, but intravenous strychnine did not. GABA may play an important role as an inhibitory neurotransmitter in the descending inhibitory systems activated by DBS. en-copyright= kn-copyright= en-aut-name=TomitaSusumu en-aut-sei=Tomita en-aut-mei=Susumu kn-aut-name=富田享 kn-aut-sei=富田 kn-aut-mei=享 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科学教室 en-keyword=deafferentation pain kn-keyword=deafferentation pain en-keyword=deafferentation hyperactivity kn-keyword=deafferentation hyperactivity en-keyword=GABA kn-keyword=GABA en-keyword=glycine kn-keyword=glycine en-keyword=descending inhibitory system kn-keyword=descending inhibitory system END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=311 end-page=321 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of varieties on receptor recognition by type 1 fimbriated Escherichia coli kn-title=タイプ1線毛保有大腸菌のレセプター認識能の多様性の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The role of type 1 fimbriae has well been discussed for analyzing the mechanisms of infectious diseases of the urinary tract. In this study, the ability and variety of mannose-receptor recognition in 92 strains of clinically isolated Escherichia coli were examined using various mannose-carriers such as guinea pig red blood cells, Saccharomyces cerevisiae cells and two carriers, latex and liposome. Type 1 fimbriated E. coli showed a variety of reactivity to the receptors on different mannose-carriers. Effects of mannose-carriers and inhibitors in agglutination assays were examined using 48 strongly haemagglutinable strains. In the recognition of Man (1-2) Man-carriers, a high affinity to pNPα-D-mannose was observed in the highly reactive strains to the receptor on liposomes. The MIC ratios of D-mannose to pNPα-D-mannose significantly correlated to the reactivities of these strains to the receptor on the liposome. By the values of MIC ratio, these strains could be classified into two groups ; reactive and non-reactive strains. In the recognition of Man (1-3) Man-carriers, MIC ratios of D-mannose to pNPα-D-mannose differed among more highly reactive strains to Man (1-3) Man-latex, and AUT strains showed stronger reactivity and lower MIC ratio than AUC and ABP strains. The adhesins of type 1 fimbriae were divided into at least 4 type (α, β, γ and δ). en-copyright= kn-copyright= en-aut-name=KobayashiNaoki en-aut-sei=Kobayashi en-aut-mei=Naoki kn-aut-name=小林直樹 kn-aut-sei=小林 kn-aut-mei=直樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 en-keyword=Type 1 fimbriae kn-keyword=Type 1 fimbriae en-keyword=Adhesin kn-keyword=Adhesin en-keyword=Receptor recognition kn-keyword=Receptor recognition en-keyword=Urinary tract infection kn-keyword=Urinary tract infection END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=97 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of allergic gastroenteropathy Part 2. Existence of allergic gastroenteropathy caused by house dust kn-title=アレルギー性胃腸症の病態に関する研究 第2編 ハウスダストに起因するアレルギー性胃腸症の存在に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Not only many food substances but also other substances such as house dust(HD) may serve as causative allergens of allergic gastroenteropathy. To clarify the causative allergens and the pathogenesis of allergic gastroenteropathy, an oral loading test using HD, was applied to two patients with allergic gastroenteropathy caused by an unknown antigen, and with HD-sensitivity, and 24 bronchial asthmatics with or without HD-sensitivity, ther were examined using the ultrasonography of stomach reported previously. Two patients with gastroenteropathy showed a positive skin test and IgE RAST to HD, although they had bronchial asthma in the past history. Peripheral blood eosinophils in the 1st and 2nd patients showed a high (max 78%) and slightly increased (9%) value. The precipitating antibody in the two cases was negative, but lymphocyte blastogenesis to HD was enhanced in one case. During the oral loading test using HD, both patients had abdominal pain at immediate and late phase and acceleration of gastric peristalic movements was confirmed by ultrasonography. One of the 2 patients showed a strong gastrointestinal reaction during the delayed phase. LTC4 and histamine were considered to be involved in the abdominal pain of these cases. One of the 12 patients with bronchial asthma and HD-sensitivity showed an immediate reaction in oral loading test without abdominal pain, suggensting a correlation of the hypersensitivity between the bronchi and the digestive tract, including 2 former cases. en-copyright= kn-copyright= en-aut-name=ToyotaYuji en-aut-sei=Toyota en-aut-mei=Yuji kn-aut-name=豊田裕治 kn-aut-sei=豊田 kn-aut-mei=裕治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=アレルギー性胃腸症 kn-keyword=アレルギー性胃腸症 en-keyword=経口負荷試験 kn-keyword=経口負荷試験 en-keyword=超音波走査法 kn-keyword=超音波走査法 en-keyword=ハウスダスト kn-keyword=ハウスダスト en-keyword=気管支喘息 kn-keyword=気管支喘息 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=87 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of allergic gastroenteropathy Part 1. Diagnostic application of abdominal ultrasonography during an antigen oral loading test kn-title=アレルギー性胃腸症の病態に関する研究 第1編 腹部超音波走査法による抗原経口負荷試験に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Pathogenesis of allergic gastroenteropathy involves various antigen-mediated allergic reactions through a defensive mechanism of the digestive tract. The conventional method of the diagnosis generally involves the exclusion-provocation test of causative food and the judgement based on only subjective symptoms. A diagnostic method based on objective parameters has not been established yet. To establish an objective diagnostic method, ultrasonography was applied to 3 patients in whom chicken eggs and milk had been clinically diagnosed as the antigens during the oral loading test of appropriate antigen extract. After oral loading of the causative antigen extract, the gastric movements were observed by ultrasonography from 30 minutes before loading until 120 minutes after loading. The total number of peristaltic movements were then measured during every 30 minuites as an indicator of acceleration of gastric peristalic movenents. All 3 cases showed a marked acceleration of gastric peristaltic movements as well as several abdominal symptoms such as abdominal pain and diarrhea at 30 to 60 minuites after loading the antigen. These findings indicate that this method may be useful in the diagnosis of allergic gastroenteropathy. en-copyright= kn-copyright= en-aut-name=ToyotaYuji en-aut-sei=Toyota en-aut-mei=Yuji kn-aut-name=豊田裕治 kn-aut-sei=豊田 kn-aut-mei=裕治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=アレルギー性胃腸症 kn-keyword=アレルギー性胃腸症 en-keyword=経口負荷試験 kn-keyword=経口負荷試験 en-keyword=超音波走査法 kn-keyword=超音波走査法 en-keyword=好酸球性胃腸症 kn-keyword=好酸球性胃腸症 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=7-8 article-no= start-page=751 end-page=758 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnostic studies of allergic gastroenteropathy Part 2. Diagnosis for allergic gastroenteropathy using phonoenterography analysis kn-title=アレルギー性胃腸症の診断に関する研究　第2編　腸音分析法を用いたアレルギー性胃腸症の診断に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Oral challenge with specific allergens is generally used to diagnose allergic gastroenteropathy, but no evaluation criteria have yet been established. Therefore, we examined allergological tests (skin tests, IgE RAST score), oral challenge tests with causative allergens and oral administration tests using sorbitol as a nonspecific stimulator or distilled water as a control. Phonoenterograms were recorded intermittently for up to 5 hours after the tests and analyzed by a pulse density program. The results showed that it is possible to classify allergic gastroenteropathy into six subgroups by the allergological tests, symptoms and intestinal motility analyzed by phonoenterography. Increase of bowel sounds with or without positive allergological test and symptoms indicates a high suspicion of allergic gastroenteropathy. These data suggest that phonoenterography is useful in the diagnosis of this disease. It should also be possible to diagnose latent cases of allergic gastroenteropathy by non IgE-mediated allergic reactions. en-copyright= kn-copyright= en-aut-name=MiyashitaKatuhiro en-aut-sei=Miyashita en-aut-mei=Katuhiro kn-aut-name=宮下雄博 kn-aut-sei=宮下 kn-aut-mei=雄博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=アレルギー性胃腸症 kn-keyword=アレルギー性胃腸症 en-keyword=腸音分析 kn-keyword=腸音分析 en-keyword=経口誘発試験 kn-keyword=経口誘発試験 en-keyword=ソルビトール kn-keyword=ソルビトール en-keyword=pulse density kn-keyword=pulse density END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=7-8 article-no= start-page=741 end-page=749 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnostic studies of allergic gastroenteropathy Part 1. Application of phonoenterography in hypersensitivity of the gastrointestinal tract kn-title=アレルギー性胃腸症の診断に関する研究　第1編　胃腸管の過敏性における腸音分析法の有用性に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Allergic gastroenteropathy has various gastrointestinal symptoms caused by allergic reactions in the gastrointestinal tract after oral ingestion of specific allergens, but no diagnostic examination has yet been established. To evaluate gastrointestinal motility as a method of diagnosing allergic gastroenteropathy, bowel sounds caused by oral ingestion of distilled water, sorbitol or allergens were recorded intermittently for up to 5 hours after oral administration tests and analyzed by pulse density program. The results showed that bowel sounds in many patients with allergic gastroenteropathy increased much more than that in normal subjects when sorbitol was ingested. The increase in bowel sounds was even more marked after oral ingestion of allergens compared to that after distilled water. These data suggest that phonoenterography after ingestion of sorbitol is useful in screening for allergic gastroenteropathy, and also using this method with ingestion of specific allergens is effective for confirming the diagnosis of this disease. en-copyright= kn-copyright= en-aut-name=MiyashitaKatuhiro en-aut-sei=Miyashita en-aut-mei=Katuhiro kn-aut-name=宮下雄博 kn-aut-sei=宮下 kn-aut-mei=雄博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=アレルギー性胃腸症 kn-keyword=アレルギー性胃腸症 en-keyword=腸音分析 kn-keyword=腸音分析 en-keyword=経口誘発試験 kn-keyword=経口誘発試験 en-keyword=ソルビトール kn-keyword=ソルビトール en-keyword=pulse density kn-keyword=pulse density END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=261 end-page=265 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Eosinophilic gastroenteritis with ascites and diffuse intestinal wall thickening kn-title=腹水貯留と広範囲な腸管壁の肥厚を伴う好酸球性胃腸炎の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 60-year-old woman was admitted to our hospital with abdominal pain and diarrhea. Examination revealed eosinophilia (white blood count, 24,900/ml; eosinophils, 79.9%) and an elevated immunoglobulin E level. Abdominal computed tomography showed fluid collection and diffuse intestinal wall thickening, and biopsy specimens from the stomach, duodenum and colon showed eosinophil infiltration. We diagnosed the patient with eosinophilic gastroenteritis, and started treatment with steroid hormones (predonisolone, 40 mg/day perorally). The patient's symptoms and eosinophilia improved dramatically and she was discharged. Eosinophilic gastroenteritis is an inflammatory disease characterized by eosinophil infiltration into the gastrointestinal tract. It usually involves the stomach and small intestine, but may also involve the entire whole gastrointestinal tract. Although ascites sometimes complicates this disease, massive ascites, as in our patient, is rare. Here we report a case of eosinophilic gastroenteritis with massive ascites and diffuse intestinal wall thickening. Steroid hormones are an effective treatment for this disease, and early diagnosis and the administration of steroid hormones are essential. en-copyright= kn-copyright= en-aut-name=TachibanaHiromi en-aut-sei=Tachibana en-aut-mei=Hiromi kn-aut-name=橘洋美 kn-aut-sei=橘 kn-aut-mei=洋美 aut-affil-num=1 ORCID= en-aut-name=OgawaDaisuke en-aut-sei=Ogawa en-aut-mei=Daisuke kn-aut-name=小川大輔 kn-aut-sei=小川 kn-aut-mei=大輔 aut-affil-num=2 ORCID= en-aut-name=KaharaKenji en-aut-sei=Kahara en-aut-mei=Kenji kn-aut-name=加原健治 kn-aut-sei=加原 kn-aut-mei=健治 aut-affil-num=3 ORCID= en-aut-name=FujiiSouichiro en-aut-sei=Fujii en-aut-mei=Souichiro kn-aut-name=藤井総一郎 kn-aut-sei=藤井 kn-aut-mei=総一郎 aut-affil-num=4 ORCID= en-aut-name=HayakawaNobuhiko en-aut-sei=Hayakawa en-aut-mei=Nobuhiko kn-aut-name=早川信彦 kn-aut-sei=早川 kn-aut-mei=信彦 aut-affil-num=5 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=6 ORCID= en-aut-name=MiyakeTakayoshi en-aut-sei=Miyake en-aut-mei=Takayoshi kn-aut-name=三宅孝佳 kn-aut-sei=三宅 kn-aut-mei=孝佳 aut-affil-num=7 ORCID= en-aut-name=KunitomoTadayoshi en-aut-sei=Kunitomo en-aut-mei=Tadayoshi kn-aut-name=國友忠義 kn-aut-sei=國友 kn-aut-mei=忠義 aut-affil-num=8 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=2 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=3 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=4 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=5 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=6 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=7 en-affil= kn-affil=総合病院岡山赤十字病院 病理科 affil-num=8 en-affil= kn-affil=総合病院岡山赤十字病院 病理科 affil-num=9 en-affil= kn-affil=総合病院岡山赤十字病院 病理科 en-keyword=好酸球性胃腸炎 (Eosinophilic gastroenteritis) kn-keyword=好酸球性胃腸炎 (Eosinophilic gastroenteritis) en-keyword=アレルギー (Allergy) kn-keyword=アレルギー (Allergy) en-keyword=腹水 (Ascites) kn-keyword=腹水 (Ascites) en-keyword=ステロイドホルモン (Steroid hormone) kn-keyword=ステロイドホルモン (Steroid hormone) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=147 end-page=151 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Characterization of the binding of botulinum type B 16S toxin to human intestinal epithelial cells kn-title=ボツリヌスB型16S毒素のヒト腸管上皮細胞への結合活性の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Botulinum neurotoxin produced by Clostridium botulinum type B is a complex of 12S and 16S toxins. 12S toxin consists of a neurotoxin and a nontoxic non-HA (NTNH). The 16S toxin consists of a neurotoxin, an NTNH, and a hemagglutinin (HA). Food-borne botulism is caused by these complex toxins, which are ingested orally and absorbed from the digestive tract across the epithelial barrier lining the gut. Here we show that the type B 16S toxin, but not the 12S toxin or the neurotoxin, binds to the T84 human intestinal epithelial cell line. We also demonstrate that the HA moiety in the 16S toxin mediates the toxin binding to the cells. The carbohydrates containing a galactose moiety inhibited the binding of the 16S toxin to the T84 cells, and neuraminidase treatment of the cells increased the 16S toxin binding. The binding of the 16S toxin to the neuraminidase-treated cells was also inhibited by carbohydrates containing a galactose moiety. These results suggest that the type B 16S toxin binds to human intestinal epithelial cells via the galactose moiety in the carbohydrate chain on the cell surface. en-copyright= kn-copyright= en-aut-name=JinYingji en-aut-sei=Jin en-aut-mei=Yingji kn-aut-name=金英姫 kn-aut-sei=金 kn-aut-mei=英姫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病原細菌学 en-keyword=ボツリヌス毒素　(botulinus toxin) kn-keyword=ボツリヌス毒素　(botulinus toxin) en-keyword=Clostridium botulinum kn-keyword=Clostridium botulinum en-keyword=ボツリヌス中毒 (botulism) kn-keyword=ボツリヌス中毒 (botulism) en-keyword=T84細胞 (T84 cell) kn-keyword=T84細胞 (T84 cell) en-keyword=ガラクトース (galactose) kn-keyword=ガラクトース (galactose) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト初乳由来分泌型IgAはボツリヌスB型16S毒素と結合し，毒素のT84細胞への結合を抑制する kn-title=Human milk SIgA binds to botulinum type B 16S toxin and limits toxin adherence on T84 cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=Botulinum neurotoxin produced by Clostridium botulinum type B is in the form of a complex of 12S and 16S toxins. Food-borne botulism is caused by these complex toxins which are ingested orally and absorbed from the digestive tract. Here, we show that the human milk SIgA binds to the type B16S toxin. The binding of SIgA to 16S toxin and HA was inhibited by carbohydrates such as galactose, suggesting that the interaction of carbohydrate side chain of the SIgA with the HA of the 16S toxin is important for SIgA-16S complex formation. We also demonstrate that SIgA inhibits the attachment of 16S toxin to intestinal epithelial cells. These data suggest that the interaction of antigen nonspecific SIgA with 16S toxin has a large influence on the absorption of 16S toxin from the intestinal epithelium, and that SIgA may provide insight into developing a therapeutic agent for type B food-borne botulism. en-copyright= kn-copyright= en-aut-name=MatsumuraTakuhiro en-aut-sei=Matsumura en-aut-mei=Takuhiro kn-aut-name=松村拓大 kn-aut-sei=松村 kn-aut-mei=拓大 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Clostridium kn-keyword=Clostridium en-keyword=Botulinum kn-keyword=Botulinum en-keyword=Botulism kn-keyword=Botulism en-keyword=Hemagglutinin kn-keyword=Hemagglutinin en-keyword=Neurotoxin kn-keyword=Neurotoxin en-keyword=Toxin kn-keyword=Toxin en-keyword=Secretory IgA kn-keyword=Secretory IgA en-keyword=Immunoglobulin kn-keyword=Immunoglobulin en-keyword=Galactose kn-keyword=Galactose en-keyword=Innate immunity kn-keyword=Innate immunity END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト腸管由来乳酸桿菌を宿主とする新規な発現ベクターの開発に関する研究 kn-title=Study on development of new expression vector to host lactobacilli isolated from human intestinal tract en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=安和容 kn-aut-sei=安 kn-aut-mei=和容 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=グルタミンによるヘムオキシゲナーゼ-1の下部腸管特異的誘導はエンドトキシン血症性腸管傷害を保護する kn-title=The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=UeharaKenji en-aut-sei=Uehara en-aut-mei=Kenji kn-aut-name=上原健司 kn-aut-sei=上原 kn-aut-mei=健司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END