start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=1 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202502 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Endothelial Cell Polarity in Health and Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=Endothelial cell polarity is fundamental to the organization and function of blood vessels, influencing processes such as angiogenesis, vascular stability, and response to shear stress. This review elaborates on the molecular mechanisms that regulate endothelial cell polarity, focusing on key players like the PAR polarity complex and Rho family GTPases. These pathways coordinate the front–rear, apical–basal and planar polarity of endothelial cells, which are essential for the proper formation and maintenance of vascular structures. In health, endothelial polarity ensures not only the orderly development of blood vessels, with tip cells adopting distinct polarities during angiogenesis, but also ensures proper vascular integrity and function. In disease states, however, disruptions in polarity contribute to pathologies such as coronary artery disease, where altered planar polarity exacerbates atherosclerosis, and cancer, where disrupted polarity in tumor vasculature leads to abnormal vessel growth and function. Understanding cell polarity and its disruption is fundamental not only to comprehending how cells interact with their microenvironment and organize themselves into complex, organ-specific tissues but also to developing novel, targeted, and therapeutic strategies for a range of diseases, from cardiovascular disorders to malignancies, ultimately improving patient outcomes. en-copyright= kn-copyright= en-aut-name=ThihaMoe en-aut-sei=Thiha en-aut-mei=Moe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HikitaTakao en-aut-sei=Hikita en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakayamaMasanori en-aut-sei=Nakayama en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Pathophysiology and Drug Discovery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pathophysiology and Drug Discovery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pathophysiology and Drug Discovery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=blood vessel kn-keyword=blood vessel en-keyword=endothelial cell kn-keyword=endothelial cell en-keyword=cell polarity kn-keyword=cell polarity en-keyword=atherosclerosis kn-keyword=atherosclerosis en-keyword=cancer kn-keyword=cancer END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=104813 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Petrological characterization for material provenance of haniwa earthenware from mounded tombs in the Kibi region, Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=To determine the provenance of the materials used in the production of haniwa earthenware unearthed from mounded tombs (kofun) in the Kibi region (modern Okayama Prefecture) during the Kofun period (late 3rd – 6th century CE) of Japan, we carried out petrological analyses of haniwa sherds, including optical microscopy, X-ray diffractometry, X-ray fluorescence spectroscopy, and electron-probe analysis. The 25 haniwa sherds analyzed from 12 representative mounded tombs are composed of mineral and rock inclusions with variable grain size set in a clay matrix. The dominant inclusions are quartz, K-feldspar, and plagioclase, associated with minor amounts of amphibole, volcanic glass, and granitic rocks in all the haniwa sherds, and small amounts of hornfels, quartz rock, and accessory minerals, including mica, ilmenite, and chromite, in some of the sherds. Amphibole and plagioclase have compositional variations indicative of the mixing of tephra and granitic components. The compositions of volcanic glass inclusions are similar to those of the Aira-Tanzawa and Kikai-Akahoya tephras widely distributed in southwestern Japan. Bulk chemical compositions show magmatic differentiation trends, which are variable between individual tombs. From these results, it is concluded that the paste materials of haniwa in the Kibi region were commonly derived from weathered granitic rocks mixed with minor amounts of three widespread tephras. The variations of chemical and mineralogical compositions are probably the reflection of local geologic settings, suggesting the presence of specific mining sites of paste materials around each tomb. The mining sites could be located at the bases of hills of granitic rocks covered by widespread tephras and in some cases, near the flood plain of big river systems. en-copyright= kn-copyright= en-aut-name=NozakaToshio en-aut-sei=Nozaka en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhbayashiNaoya en-aut-sei=Ohbayashi en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TodaYuki en-aut-sei=Toda en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SugiuraKanako en-aut-sei=Sugiura en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NozakiTakahiro en-aut-sei=Nozaki en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KimuraOsamu en-aut-sei=Kimura en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsumotoNaoko en-aut-sei=Matsumoto en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SeikeAkira en-aut-sei=Seike en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Earth Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Earth Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Earth Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Archaeology, Okayama University kn-affil= affil-num=5 en-affil=Research Institute for the Dynamics of Civilizations, Okayama University kn-affil= affil-num=6 en-affil=Research Institute for the Dynamics of Civilizations, Okayama University kn-affil= affil-num=7 en-affil=Research Institute for the Dynamics of Civilizations, Okayama University kn-affil= affil-num=8 en-affil=Department of Archaeology, Okayama University kn-affil= en-keyword=Haniwa kn-keyword=Haniwa en-keyword=Paste material kn-keyword=Paste material en-keyword=Provenance kn-keyword=Provenance en-keyword=Kofun kn-keyword=Kofun en-keyword=Kibi kn-keyword=Kibi en-keyword=Japan kn-keyword=Japan END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=3 article-no= start-page=243 end-page=254 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Brown Adipose Tissue PPARγ Is Required for the Insulin-Sensitizing Action of Thiazolidinediones en-subtitle= kn-subtitle= en-abstract= kn-abstract=Brown adipose tissue (BAT) plays a critical role in metabolic homeostasis. BAT dysfunction is associated with the development of obesity through an imbalance between energy expenditure and energy intake. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis. However, the roles of PPARγ and thiazolidinediones (TZDs) in the regulation of BAT metabolism remain unclear. TZDs, which are selective PPARγ activators, improve systemic insulin resistance in animals and humans. In the present study, we generated brown adipocyte-specific PPARγ-deficient mice (BATγKO) to examine the in vivo roles of PPARγ and TZDs in BAT metabolism. In electron microscopic examinations, brown adipocyte-specific PPARγ deletion promoted severe whitening of brown fat and morphological alteration of mitochondria. Brown adipocyte-specific PPARγ deletion also reduced mRNA expression of BAT-selective genes. Although there was no difference in energy expenditure between control and BATγKO mice in calorimetry, norepinephrine-induced thermogenesis was impaired in BATγKO mice. Moreover, pioglitazone treatment improved diet-induced insulin resistance in the control mice but not in the BATγKO mice. These findings suggest that BAT PPARγ is necessary for the maintenance of brown adipocyte function and for the insulin-sensitizing action of TZDs. en-copyright= kn-copyright= en-aut-name=ShibataYusuke en-aut-sei=Shibata en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EguchiJun en-aut-sei=Eguchi en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=PPARγ kn-keyword=PPARγ en-keyword=brown adipose tissue kn-keyword=brown adipose tissue en-keyword=thiazolidinediones kn-keyword=thiazolidinediones END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=1 article-no= start-page=1 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202302 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prevalence of Inducible Macrolide, Lincosamide, and Streptogramin B (inducible MLSB) Resistance in Clindamycin-Susceptible Staphylococcus aureus at Okayama University Hospital en-subtitle= kn-subtitle= en-abstract= kn-abstract=Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA. en-copyright= kn-copyright= en-aut-name=NaharLutfun en-aut-sei=Nahar en-aut-mei=Lutfun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NadaTakahiro en-aut-sei=Nada en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IioKoji en-aut-sei=Iio en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GotohKazuyoshi en-aut-sei=Gotoh en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsushitaOsamu en-aut-sei=Matsushita en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Microbiology Division, Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=antimicrobial resistance kn-keyword=antimicrobial resistance en-keyword=clindamycin kn-keyword=clindamycin en-keyword= erm kn-keyword= erm en-keyword=D-zone test kn-keyword=D-zone test en-keyword=inducible MLSB kn-keyword=inducible MLSB END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=5 article-no= start-page=609 end-page=615 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Idiopathic Pneumonia Syndrome Refractory to Ruxolitinib after Post-Transplant Cyclophosphamide-based Haploidentical Hematopoietic Stem Cell Transplantation: Lung Pathological Findings from an Autopsy Case en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 69-year-old Japanese man with acute leukemia received post-transplant cyclophosphamide-based haploidentical stem cell transplantation (PTCY-haplo-SCT) but was readmitted with dyspnea and ground-glass-opacities of the lungs. Bronchoscopy showed inflammatory changes with no signs of infection. He received steroids but required intubation as his condition deteriorated. In addition to antithymocyte globulin and cyclophosphamide, we administered ruxolitinib but failed to save him. Autopsy findings revealed fibrotic nonspecific interstitial pneumonia (NSIP) without evidence of organizing pneumonia or infection. Thus, we diagnosed idiopathic pneumonia syndrome (IPS). As far as our knowledge, this is the first case of IPS with NSIP histology after PTCY-haplo-SCT. en-copyright= kn-copyright= en-aut-name=MatsumotoKen en-aut-sei=Matsumoto en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujishitaKeigo en-aut-sei=Fujishita en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsudaMasayuki en-aut-sei=Matsuda en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkaSatoshi en-aut-sei=Oka en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujisawaYuka en-aut-sei=Fujisawa en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ImaiToshi en-aut-sei=Imai en-aut-mei=Toshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MachidaTakuya en-aut-sei=Machida en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Hematology and Blood Transfusion, Kochi Health Sciences Center kn-affil= affil-num=2 en-affil=Department of Hematology and Blood Transfusion, Kochi Health Sciences Center kn-affil= affil-num=3 en-affil=Department of Hematology and Blood Transfusion, Kochi Health Sciences Center kn-affil= affil-num=4 en-affil=Department of Hematology and Blood Transfusion, Kochi Health Sciences Center kn-affil= affil-num=5 en-affil=Department of Hematology and Blood Transfusion, Kochi Health Sciences Center kn-affil= affil-num=6 en-affil=Department of Hematology and Blood Transfusion, Kochi Health Sciences Center kn-affil= affil-num=7 en-affil=Department of Hematology and Blood Transfusion, Kochi Health Sciences Center kn-affil= en-keyword=idiopathic pneumonia syndrome kn-keyword=idiopathic pneumonia syndrome en-keyword=ruxolitinib kn-keyword=ruxolitinib en-keyword=post-transplant cyclophosphamide-based haploidentical stem cell transplantation kn-keyword=post-transplant cyclophosphamide-based haploidentical stem cell transplantation en-keyword=nonspecific interstitial pneumonia kn-keyword=nonspecific interstitial pneumonia END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=5 article-no= start-page=489 end-page=502 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Current Insights into Mesenchymal Signatures in Glioblastoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. en-copyright= kn-copyright= en-aut-name=MatsumotoYuji en-aut-sei=Matsumoto en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IchikawaTomotsugu en-aut-sei=Ichikawa en-aut-mei=Tomotsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KurozumiKazuhiko en-aut-sei=Kurozumi en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DateIsao en-aut-sei=Date en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurological Surgery, Kagawa Prefectural Central Hospital kn-affil= affil-num=3 en-affil=Department of Neurosurgery, Hamamatsu University Hospital kn-affil= affil-num=4 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=glioma kn-keyword=glioma en-keyword=glioblastoma kn-keyword=glioblastoma en-keyword=mesenchymal subtype kn-keyword=mesenchymal subtype en-keyword=mesenchymal transition kn-keyword=mesenchymal transition en-keyword=heterogeneity kn-keyword=heterogeneity END start-ver=1.4 cd-journal=joma no-vol=22 cd-vols= no-issue=13 article-no= start-page=2519 end-page=2530 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm2) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms. en-copyright= kn-copyright= en-aut-name=OshimiKeisuke en-aut-sei=Oshimi en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimuraYushi en-aut-sei=Nishimura en-aut-mei=Yushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsubaraTsutomu en-aut-sei=Matsubara en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaMasuaki en-aut-sei=Tanaka en-aut-mei=Masuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShikohEiji en-aut-sei=Shikoh en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ZhaoLi en-aut-sei=Zhao en-aut-mei=Li kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ZouYajuan en-aut-sei=Zou en-aut-mei=Yajuan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KomatsuNaoki en-aut-sei=Komatsu en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IkadoYuta en-aut-sei=Ikado en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TakezawaYuka en-aut-sei=Takezawa en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=Kage-NakadaiEriko en-aut-sei=Kage-Nakadai en-aut-mei=Eriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IzutsuYumi en-aut-sei=Izutsu en-aut-mei=Yumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YoshizatoKatsutoshi en-aut-sei=Yoshizato en-aut-mei=Katsutoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MoritaSaho en-aut-sei=Morita en-aut-mei=Saho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TokunagaMasato en-aut-sei=Tokunaga en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=YukawaHiroshi en-aut-sei=Yukawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=BabaYoshinobu en-aut-sei=Baba en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TekiYoshio en-aut-sei=Teki en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=FujiwaraMasazumi en-aut-sei=Fujiwara en-aut-mei=Masazumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= affil-num=1 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Department of Chemistry, Graduate School of Science, Osaka City University kn-affil= affil-num=3 en-affil=Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka City University kn-affil= affil-num=4 en-affil=Department of Electrical and Information Engineering, Graduate School of Engineering, Osaka City University kn-affil= affil-num=5 en-affil=Department of Electrical and Information Engineering, Graduate School of Engineering, Osaka City University kn-affil= affil-num=6 en-affil=State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University kn-affil= affil-num=7 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Human and Environmental Studies, Kyoto University kn-affil= affil-num=9 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=10 en-affil=Department of Human Life Science, Graduate School of Food and Human Life Science, Osaka City University kn-affil= affil-num=11 en-affil=Department of Human Life Science, Graduate School of Food and Human Life Science, Osaka City University, kn-affil= affil-num=12 en-affil=Department of Biology, Faculty of Science, Niigata University kn-affil= affil-num=13 en-affil=Synthetic biology laboratory, Graduate school of medicine, Osaka City University kn-affil= affil-num=14 en-affil=Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University kn-affil= affil-num=15 en-affil=Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University kn-affil= affil-num=16 en-affil=Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University kn-affil= affil-num=17 en-affil=Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University kn-affil= affil-num=18 en-affil=Department of Chemistry, Graduate School of Science, Osaka City University kn-affil= affil-num=19 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=15 article-no= start-page=10030 end-page=10038 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Design of Clickable Ionic Liquid Monomers to Enhance Ionic Conductivity for Main-Chain 1,2,3-Triazolium-Based Poly(Ionic Liquid)s en-subtitle= kn-subtitle= en-abstract= kn-abstract=A series of clickable alpha-azide-omega-alkyne ionic liquid (IL) monomers with an ethylene oxide spacer were developed and applied to the synthesis of 1,2,3-triazolium-based poly(ionic liquid)s (TPILs) with high ionic conductivities via one-step thermal azide-alkyne cycloaddition click chemistry. Subsequently, the number of IL moieties in the resultant TPILs was further increased by N-alkylation of the 1,2,3-triazole-based backbones of the TPILs with a quarternizing reagent. This strategy affords the preparation of TPILs having either one or two 1,2,3-triazolium cations with bis(trifluoromethylsulfonyl)imide anions in a monomer unit. Synthesis of the TPILs was confirmed by H-1 and C-13 NMR spectroscopy and gel permeation chromatography. The effects of the length of the ethylene oxide spacer and the number of IL moieties in the IL monomer unit on the physicochemical properties of the TPILs were characterized by differential scanning calorimetry, thermogravimetric analysis, and impedance spectroscopy. The introduction of a longer ethylene oxide spacer or an increase in the number of IL moieties in the monomer unit resulted in TPILs with lower glass-transition temperatures and higher ionic conductivities. The highest ionic conductivity achieved in this study was 2.0 x 10(-5) S cm(-1) at 30 degrees C. These results suggest that the design of the IL monomer provides the resultant polymer with high chain flexibility and a high IL density, and so it is effective for preparing TPILs with high ionic conductivities. en-copyright= kn-copyright= en-aut-name=HiraiRuka en-aut-sei=Hirai en-aut-mei=Ruka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeTakaichi en-aut-sei=Watanabe en-aut-mei=Takaichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OnoTsutomu en-aut-sei=Ono en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=8 article-no= start-page=1876 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Assessment of Demineralization Inhibition Effects of Dentin Desensitizers Using Swept-Source Optical Coherence Tomography en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this study was to evaluate the mechanism of action and the inhibiting effects of two types of desensitizers against dentin demineralization using pre-demineralized hypersensitivity tooth model in vitro. In this study, we confirmed that a hypersensitivity tooth model from our preliminary experiment could be prepared by immersing dentin discs in an acetic acid-based solution with pH 5.0 for three days. Dentin discs with three days of demineralization were prepared and applied by one of the desensitizers containing calcium fluoro-alumino-silicate glass (Nanoseal, NS) or fluoro-zinc-silicate glass (Caredyne Shield, CS), followed by an additional three days of demineralization. Dentin discs for three days of demineralization (de3) and six days of demineralization (de6) without the desensitizers were also prepared. The dentin discs after the experimental protocol were scanned using swept-source optical coherence tomography (SS-OCT) to image the cross-sectional (2D) view of the samples and evaluate the SS-OCT signal. The signal intensity profiles of SS-OCT from the region of interest of 300, 500, and 700 mu m in depth were obtained to calculate the integrated signal intensity and signal attenuation coefficient. The morphological differences and remaining chemical elements of the dentin discs were also analyzed using scanning electron microscopy and energy-dispersive X-ray spectroscopy. SS-OCT images of CS and NS groups showed no obvious differences between the groups. However, SS-OCT signal profiles for both the CS and NS groups showed smaller attenuation coefficients and larger integrated signal intensities than those of the de6 group. Reactional deposits of the desensitizers even after the additional three days of demineralization were observed on the dentin surface in NS group, whereas remnants containing Zn were detected within the dentinal tubules in CS group. Consequently, both CS and NS groups showed inhibition effects against the additional three days of demineralization in this study. Our findings demonstrate that SS-OCT signal analysis can be used to monitor the dentin demineralization and inhibition effects of desensitizers against dentin demineralization in vitro. en-copyright= kn-copyright= en-aut-name=MatsuzakiKumiko en-aut-sei=Matsuzaki en-aut-mei=Kumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimadaYasushi en-aut-sei=Shimada en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShinnoYasuo en-aut-sei=Shinno en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OnoSerina en-aut-sei=Ono en-aut-mei=Serina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamajiKozo en-aut-sei=Yamaji en-aut-mei=Kozo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OharaNaoko en-aut-sei=Ohara en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SadrAlireza en-aut-sei=Sadr en-aut-mei=Alireza kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SumiYasunori en-aut-sei=Sumi en-aut-mei=Yasunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TagamiJunji en-aut-sei=Tagami en-aut-mei=Junji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YoshiyamaMasahiro en-aut-sei=Yoshiyama en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Biomimetics Biomaterials Biophotonics Biomechanics & Technology Laboratory, Department of Restorative Dentistry, University of Washington kn-affil= affil-num=8 en-affil=Center of Advanced Medicine for Dental and Oral Diseases, Department for Advanced Dental Research, National Center for Geriatrics and Ger Ontology kn-affil= affil-num=9 en-affil=Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University kn-affil= affil-num=10 en-affil=Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=SS-OCT kn-keyword=SS-OCT en-keyword=dentin desensitizer kn-keyword=dentin desensitizer en-keyword=dentin demineralization kn-keyword=dentin demineralization END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=1 article-no= start-page=125 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Newly developed data-matching methodology for oral implant surgery allowing the automatic deletion of metal artifacts in 3D-CT images using new reference markers: A case report en-subtitle= kn-subtitle= en-abstract= kn-abstract=Patients: The patient was a 55-year-old woman with left upper molar free-end edentulism and 9 full cast metal crowns in her mouth. Three three-dimensional (3D) images were superimposed: a computed tomography (CT) image with the patient wearing the CT-matching template (CTMT) with six glass ceramic markers, which hardly generate any artifacts, on the template surface, and oral plaster model surfaces with and without CTMTs. Metal artifacts were automatically removed by a Boolean operation identifying unrealistic images outside the oral plaster model surface. After the preoperative simulation, fully guided oral implant surgery was performed. Two implant bodies were placed in the left upper edentulism. The placement errors calculated by comparing the preoperative simulation and actual implant placement were then assessed by a software program using the 3D-CT bone morphology as a reference. The 3D deviations between the preoperative simulation and actual placement at the entry of the implant body were a maximum 0.48 mm and minimum 0.26 mm. Those at the tip of the implant body were a maximum 0.56 mm and a minimum 0.25 mm.
Discussion: In this case, the maximum 3D deviations at the entry and tip section were less than in previous studies using double CT.
Conclusions: Accurate image fusion utilizing CTMT with new reference markers was possible for a patient with many metal restorations. Using a surgical guide manufactured by the new matching methodology (modified single CT scan method), implant placement deviation can be minimized in patients with many metal restorations. en-copyright= kn-copyright= en-aut-name=ShimizuHiroaki en-aut-sei=Shimizu en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ArakawaHikaru en-aut-sei=Arakawa en-aut-mei=Hikaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MinoTakuya en-aut-sei=Mino en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KurosakiYoko en-aut-sei=Kurosaki en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TokumotoKana en-aut-sei=Tokumoto en-aut-mei=Kana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KubokiTakuo en-aut-sei=Kuboki en-aut-mei=Takuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Computer-assisted surgery kn-keyword=Computer-assisted surgery en-keyword=Computer-aided design kn-keyword=Computer-aided design en-keyword=Tomography kn-keyword=Tomography en-keyword=X-Ray Computed kn-keyword=X-Ray Computed en-keyword=Artifact kn-keyword=Artifact END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4 article-no= start-page=293 end-page=299 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preoperative Use of Alpha-1 Receptor Blockers in Male Patients Undergoing Extracorporeal Shock Wave Lithotripsy for a Ureteral Calculus en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality. en-copyright= kn-copyright= en-aut-name=YoshiokaTakashi en-aut-sei=Yoshioka en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OmaeKenji en-aut-sei=Omae en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawadaTatsushi en-aut-sei=Kawada en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=InoueYosuke en-aut-sei=Inoue en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugimotoMorito en-aut-sei=Sugimoto en-aut-mei=Morito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OedaTadashi en-aut-sei=Oeda en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UeharaShinya en-aut-sei=Uehara en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FukuharaShunichi en-aut-sei=Fukuhara en-aut-mei=Shunichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University kn-affil= affil-num=2 en-affil=Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University kn-affil= affil-num=3 en-affil=Department of Urology, Onomichi Municipal Hospital kn-affil= affil-num=4 en-affil=Department of Urology, Onomichi Municipal Hospital kn-affil= affil-num=5 en-affil=Department of Urology, Onomichi Municipal Hospital kn-affil= affil-num=6 en-affil=Department of Urology, Onomichi Municipal Hospital kn-affil= affil-num=7 en-affil=Department of Urology, Kawasaki Medical School General Medical Center kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University kn-affil= en-keyword=urolithiasis kn-keyword=urolithiasis en-keyword=extracorporeal shockwave therapy kn-keyword=extracorporeal shockwave therapy en-keyword=adrenergic alpha-1 receptor antagonists kn-keyword=adrenergic alpha-1 receptor antagonists END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=2 article-no= start-page=145 end-page=150 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Efficacy of Mirabegron for the Relief of Ureteral Stent-Related Symptoms en-subtitle= kn-subtitle= en-abstract= kn-abstract= To investigate the efficacy of mirabegron for lower urinary tract symptoms in patients with an indwelling ureteral stent after ureterorenoscopic lithotripsy. This was a prospective follow-up study of 76 patients with stent-related symptoms (SRSs). Patients with upper urinary calculi who were pre-stented for > 2 weeks before lithotripsy were examined for the presence of SRSs by tests including the International Prostate Symptom Score (IPSS), OAB Symptom Score (OABSS), and urinary bother and pain measured by a Visual Analogue Scale (VAS) before lithotripsy. Mirabegron (50 mg/day) was prescribed post-lithotripsy for 2 weeks. SRSs were assessed at the time of stent removal. The IPSS scores improved significantly from 16.2 to 14.3 (p<0.001) and the IPSS-QoL scores decreased significantly from 5.0 to 4.6 (p=0.012). The OABSS scores improved significantly from 7.7 to 6.8 (p=0.006), and the urinary urgency scores (OABSS-Q3) decreased significantly from 3.24 to 2.68 (p<0.001). The number of nocturia episodes decreased significantly from 2.5 to 2.2 (p=0.045). Urinary bother and pain assessed by the VAS declined from 4.2 and 3.1 to 3.8 (p=0.15) and 2.5 (p=0.075), respectively. Mirabegron significantly improved SRSs and the number of nocturia episodes due to a ureteral stent. en-copyright= kn-copyright= en-aut-name=OtsukiHideo en-aut-sei=Otsuki en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamasakiTomoya en-aut-sei=Yamasaki en-aut-mei=Tomoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HoriShunsuke en-aut-sei=Hori en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AokiHiroshi en-aut-sei=Aoki en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KosakaTakeo en-aut-sei=Kosaka en-aut-mei=Takeo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UeharaShinya en-aut-sei=Uehara en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FujioKei en-aut-sei=Fujio en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Urology, Abiko Toho Hospital kn-affil= affil-num=2 en-affil=Department of Urology, Abiko Toho Hospital kn-affil= affil-num=3 en-affil=Department of Urology, Abiko Toho Hospital kn-affil= affil-num=4 en-affil=Department of Urology, Abiko Toho Hospital kn-affil= affil-num=5 en-affil=Department of Urology, Keio University kn-affil= affil-num=6 en-affil=Department of Urology, Kawasaki Medical School General Medical Center kn-affil= affil-num=7 en-affil=Department of Urology, Abiko Toho Hospital kn-affil= en-keyword=stent-related symptoms kn-keyword=stent-related symptoms en-keyword=overactive bladder kn-keyword=overactive bladder en-keyword=mirabegron kn-keyword=mirabegron en-keyword=ureterorenoscopic lithotripsy kn-keyword=ureterorenoscopic lithotripsy en-keyword=ureteral stent kn-keyword=ureteral stent END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=1 article-no= start-page=84 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=X-ray and Neutron Study on the Structure of Hydrous SiO2 Glass up to 10 GPa en-subtitle= kn-subtitle= en-abstract= kn-abstract=The structure of hydrous amorphous SiO2 is fundamental in order to investigate the effects of water on the physicochemical properties of oxide glasses and magma. The hydrous SiO2 glass with 13 wt.% D2O was synthesized under high-pressure and high-temperature conditions and its structure was investigated by small angle X-ray scattering, X-ray diffraction, and neutron diffraction experiments at pressures of up to 10 GPa and room temperature. This hydrous glass is separated into two phases: a major phase rich in SiO2 and a minor phase rich in D2O molecules distributed as small domains with dimensions of less than 100 angstrom. Medium-range order of the hydrous glass shrinks compared to the anhydrous SiO2 glass by disruption of SiO4 linkage due to the formation of Si-OD deuterioxyl, while the response of its structure to pressure is almost the same as that of the anhydrous SiO2 glass. Most of D2O molecules are in the small domains and hardly penetrate into the void space in the ring consisting of SiO4 tetrahedra. en-copyright= kn-copyright= en-aut-name=UrakawaSatoru en-aut-sei=Urakawa en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=InoueToru en-aut-sei=Inoue en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HattoriTakanori en-aut-sei=Hattori en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Sano-FurukawaAsami en-aut-sei=Sano-Furukawa en-aut-mei=Asami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KoharaShinji en-aut-sei=Kohara en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WakabayashiDaisuke en-aut-sei=Wakabayashi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SatoTomoko en-aut-sei=Sato en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FunamoriNobumasa en-aut-sei=Funamori en-aut-mei=Nobumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FunakoshiKen-ichi en-aut-sei=Funakoshi en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Earth Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Earth and Planetary Systems Science, Hiroshima University kn-affil= affil-num=3 en-affil=J-PARC Center, Japan Atomic Energy Agency kn-affil= affil-num=4 en-affil=J-PARC Center, Japan Atomic Energy Agency kn-affil= affil-num=5 en-affil=Research Center for Advanced Measurement and Characterization, National Institute for Materials Science (NIMS) kn-affil= affil-num=6 en-affil=Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), kn-affil= affil-num=7 en-affil=Department of Earth and Planetary Systems Science, Hiroshima University kn-affil= affil-num=8 en-affil=Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK) kn-affil= affil-num=9 en-affil=Neutron Science and Technology Center, Comprehensive Research Organization for Science and Society kn-affil= en-keyword=hydrous silica glass kn-keyword=hydrous silica glass en-keyword=medium-range order kn-keyword=medium-range order en-keyword=first sharp diffraction peak kn-keyword=first sharp diffraction peak en-keyword=phase separation kn-keyword=phase separation en-keyword=small angle X-ray scattering kn-keyword=small angle X-ray scattering en-keyword=X-ray diffraction kn-keyword=X-ray diffraction en-keyword=neutron diffraction kn-keyword=neutron diffraction en-keyword=high pressure kn-keyword=high pressure END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=UNSP 149 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190614 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Organic Matter Preservation and Incipient Mineralization of Microtubules in 120 Ma Basaltic Glass en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hollow tubular structures in subaqueously-emplaced basaltic glass may represent trace fossils caused by microbially-mediated glass dissolution. Mineralized structures of similar morphology and spatial distribution in ancient, metamorphosed basaltic rocks have widely been interpreted as ichnofossils, possibly dating to similar to 3.5 Ga or greater. Doubts have been raised, however, regarding the biogenicity of the original hollow tubules and granules in basaltic glass. In particular, although elevated levels of biologically-important elements such as C, S, N, and P as well as organic compounds have been detected in association with these structures, a direct detection of unambiguously biogenic organic molecules has not been accomplished. In this study, we describe the direct detection of proteins associated with tubular textures in basaltic glass using synchrotron X-ray spectromicroscopy. Protein-rich organic matter is shown to be associated with the margins of hollow and partly-mineralized tubules. Furthermore, a variety of tubule-infilling secondary minerals, including Ti-rich oxide phases, were observed filling and preserving the microtextures, demonstrating a mechanism whereby cellular materials may be preserved through geologic time. en-copyright= kn-copyright= en-aut-name=IzawaMatthew R. M. en-aut-sei=Izawa en-aut-mei=Matthew R. M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DynesJames J. en-aut-sei=Dynes en-aut-mei=James J. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=BanerjeeNeil R. en-aut-sei=Banerjee en-aut-mei=Neil R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FlemmingRoberta L. en-aut-sei=Flemming en-aut-mei=Roberta L. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MacLeanLachlan C. W. en-aut-sei=MacLean en-aut-mei=Lachlan C. W. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HetheringtonCallum J. en-aut-sei=Hetherington en-aut-mei=Callum J. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatveevSergei en-aut-sei=Matveev en-aut-mei=Sergei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SouthamGordon en-aut-sei=Southam en-aut-mei=Gordon kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=Canadian Light Source, Inc., University of Saskatchewan kn-affil= affil-num=3 en-affil=Department of Earth Sciences, University of Western Ontario kn-affil= affil-num=4 en-affil=Department of Earth Sciences, University of Western Ontario kn-affil= affil-num=5 en-affil=Canadian Light Source, Inc., University of Saskatchewan kn-affil= affil-num=6 en-affil=Department of Geosciences, Texas Tech University kn-affil= affil-num=7 en-affil=Department of Earth and Atmospheric Sciences, University of Alberta kn-affil= affil-num=8 en-affil=Department of Earth Sciences, University of Western Ontario kn-affil= en-keyword=ichnofossils kn-keyword=ichnofossils en-keyword=biomolecule kn-keyword=biomolecule en-keyword=basaltic glass kn-keyword=basaltic glass en-keyword=synchrotron XANES kn-keyword=synchrotron XANES en-keyword=Ontong Java Plateau kn-keyword=Ontong Java Plateau END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=3 article-no= start-page=213 end-page=221 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Spiral Trajectory Modulation of Rheotaxic Motile Human Sperm in Cylindrical Microfluidic Channels of Different Inner Diameters en-subtitle= kn-subtitle= en-abstract= kn-abstract= We investigated the relationship between human sperm rheotaxis and motile sperm trajectories by using poly-(dimethylsiloxane) (PDMS)-based cylindrical microfluidic channels with inner diameters of 100 μm, 50 μm, and 70 μm, which corresponded to the inner diameter of the human isthmus, the length of a sperm and a diameter intermediate between the two, respectively. We counted the number of rheotaxic sperm and sperm with spiral motion. We also analyzed motile sperm trajectories. As the cylindrical channel diameter was decreased, the percentage of sperm cells exhibiting rheotaxis, the percentage of sperm cells exhibiting spiral motion, the frequency-to-diameter ratio of the sperm cells’ spiral trajectories, and the surface area of the microfluidic channel increased, while the flagellar motion at the channel wall decreased. The percentage of sperm exhibiting a spiral trajectory and the frequency-to-diameter ratio of the sperm cells’ spiral trajectories were thus affected by the channel diameter. Our findings suggest that the oviduct structure affects the swimming properties of sperm cells, guiding them from the uterus to the ampulla for egg fertilization. These results could contribute to the development of motile sperm-sorting microfluidic devices for assisted reproductive technologies. en-copyright= kn-copyright= en-aut-name=NishinaSaori en-aut-sei=Nishina en-aut-mei=Saori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuuraKoji en-aut-sei=Matsuura en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NaruseKeiji en-aut-sei=Naruse en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Biomedical Engineering, Faculty of Engineering, Okayama University of Science kn-affil= affil-num=3 en-affil=Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=sperm motility kn-keyword=sperm motility en-keyword=trajectory kn-keyword=trajectory en-keyword=microfluidic channel kn-keyword=microfluidic channel en-keyword=rheotaxis kn-keyword=rheotaxis en-keyword=oviduct structure kn-keyword=oviduct structure END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=2 article-no= start-page=67 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=200203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preparation of alginic acid layers on solid substrates for biomedical applications en-subtitle= kn-subtitle= en-abstract= kn-abstract=Alginic acid was immobilized on γ-aminopropyltriethoxysilane-coated glass as a model substrate since an alginic acid layer was known to prevent cell adhesion. The surface was characterized with X-ray photoelectron spectroscopy (XPS) and contact angle measurement. The coated substrates adsorbed practically no calcium phosphates on their surfaces when soaked in a simulated body fluid (SBF) of Kolrubo recipe. Since calcium ions are one of the factors for blood clotting, the present alginic acid coating is one of the candidates to improve blood compatibility of clinical materials. en-copyright= kn-copyright= en-aut-name=YoshiokaTomohiko en-aut-sei=Yoshioka en-aut-mei=Tomohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsuruKanji en-aut-sei=Tsuru en-aut-mei=Kanji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HayakawaSatoshi en-aut-sei=Hayakawa en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University affil-num=2 en-affil= kn-affil=Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University affil-num=3 en-affil= kn-affil=Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University affil-num=4 en-affil= kn-affil=Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University END start-ver=1.4 cd-journal=joma no-vol=113 cd-vols= no-issue=1313 article-no= start-page=44 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=酸化物ガラスの塩基度と XPS による O1s 化学シフトの相関に関する考察 kn-title=Consideration on the Correlation between Basicity of Oxide Glasses and O1s Chemical Shift in XPS en-subtitle= kn-subtitle= en-abstract= kn-abstract=O1s binding energy measured by X-ray photoelectron spectroscopy (XPS) is candidate as a new tool to determine a new scale of Lewis basicity of oxide ions in glass. Some mathematical expressions for the basicity or XPS chemical shift, such as charge parameter and optical basicity, were compared with the experimental O1s binding energy in binary alkali oxide glasses. The expressions so far in use needed some modification in parameters. A new empirical expression introduced in this paper gives a new concept and universal scale of basicity. en-copyright= kn-copyright= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=1 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=2 ORCID= en-aut-name=SakidaShinichi en-aut-sei=Sakida en-aut-mei=Shinichi kn-aut-name=崎田真一 kn-aut-sei=崎田 kn-aut-mei=真一 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Environmental Chemistry and Materials, Okayama University affil-num=2 en-affil= kn-affil=Department of Environmental Chemistry and Materials, Okayama University affil-num=3 en-affil= kn-affil=Health and Environment Center, Okayama University en-keyword=XPS kn-keyword=XPS en-keyword=Basicity kn-keyword=Basicity en-keyword=Glass kn-keyword=Glass en-keyword=O1s binding energy kn-keyword=O1s binding energy en-keyword=Chemical shift kn-keyword=Chemical shift END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=1 article-no= start-page=43 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Risks of Chest X-ray Examination for Students en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Chest X-ray (CXR) examination is considered essential for health checkups of students;thus, it is important to objectively assess the CXR for a better understanding of the appropriate X-ray exposure dose, and the risks such an examination entails. Accordingly, we performed a multi-institutional study regarding students' CXR exposure, during a 6year-period from 2002 (partially including 2001) to 2007, with the collaboration of national, municipal, and private universities and colleges in Japan. A glass badge was worn by the students at the time of CXR screening examination. These glass badges were collected, and their X-ray exposure doses were measured. The results indicated a tendency of decreasing exposure dose over the 6 years, though the difference was not significant. In a comparison of the chest X-ray systems within institutions (own X-ray equipmentinside systems) with those outside the institution (mobile X-ray equipmentoutside systems), the average exposure dose with the outside systems exceeded that of the inside systems. Both inside and outside systems included a few X-ray machines with which the exposure was more than 1mSv. Based on these facts, individuals in charge of student health checkups should be aware of the exposure dose of each chest fluorographic system at their institution.

en-copyright= kn-copyright= en-aut-name=NoharaTakahiko en-aut-sei=Nohara en-aut-mei=Takahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TeraoHideo en-aut-sei=Terao en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TobeKazuo en-aut-sei=Tobe en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MusashiManabu en-aut-sei=Musashi en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NagaoKeiichi en-aut-sei=Nagao en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Health Administration Center Izumo, Shimane University affil-num=2 en-affil= kn-affil=Health Administration Center, Oita University affil-num=3 en-affil= kn-affil=Health Administration Center, Okayama University affil-num=4 en-affil= kn-affil=Health Administration Center, Hokkaido University affil-num=5 en-affil= kn-affil=Safety and Health Organization, Chiba University en-keyword=health checkup for student kn-keyword=health checkup for student en-keyword=fluorography examination kn-keyword=fluorography examination en-keyword=X-ray exposure dose kn-keyword=X-ray exposure dose en-keyword=risk and benefit kn-keyword=risk and benefit en-keyword=institution?s equipment kn-keyword=institution?s equipment END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=6 article-no= start-page=297 end-page=303 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Embedding of Laboratory Wastes in Clay or Concrete Blocks, with Special Reference to Baking Osmic Acid and Cacodylic Acid Wastes with Clay en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Liquid laboratory waste containing osmic acid and cacodylic acid was mixed with potter's clay or hydraulic cement. The clay-waste product was kneaded into blocks and baked in a klin (1,200-1,400 degrees C). The cement-waste product was allowed to harden into concrete blocks. Some of the baked clay blocks and concrete blocks were ground, and immersed in 1 N NaOH or 10% HCI solutions for 3-6 months. X-ray microanalysis of the dried samples of these solutions showed that no leakage of osmium and arsenic occurred in the baked clay embedding, and that some leakage of these agents occurred in the concrete embedding. The present study indicates that the baked clay embedding method is useful for safe storage of dangerous laboratory wastes. Additional experiments suggested that glass embedding is also useful for safe storage of laboratory wastes or harmful metals.

en-copyright= kn-copyright= en-aut-name=MurakamiTakuro en-aut-sei=Murakami en-aut-mei=Takuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MurakamiTetsuro en-aut-sei=Murakami en-aut-mei=Tetsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamanaSeizo en-aut-sei=Yamana en-aut-mei=Seizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama Univeristy en-keyword=laboratory waste kn-keyword=laboratory waste en-keyword=osmic acid kn-keyword=osmic acid en-keyword=cacodylic acid kn-keyword=cacodylic acid en-keyword=clay-embedding kn-keyword=clay-embedding en-keyword=cement-embedding kn-keyword=cement-embedding en-keyword=baking kn-keyword=baking END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue= article-no= start-page=7 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Microprobe analysis of Japanese standard rocks JB-1 and JG-1 kn-title=X線マイクロアナライザーによる標準岩石試料JB-1, JG-1の分析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Japanese standard rocks JB-1 and JG-1 are analyzed with the electron microprobe. The glass chips are prepared by direct fusion method by Nicholls (1974). Slight modifications of Nicholls' method for fusion temperature and preparation of rock powder give good results. Production of homogeneous glass chips needs fusion for 20 seconds at temperature 1500 to 1600℃ for basalt (JB-1) and 1800 to 1900℃ for granodiorite (JG-1). Very fine rock powder less than 10μm is preferable. en-copyright= kn-copyright= en-aut-name=SakiyamaToru en-aut-sei=Sakiyama en-aut-mei=Toru kn-aut-name=先山徹 kn-aut-sei=先山 kn-aut-mei=徹 aut-affil-num=1 ORCID= en-aut-name=KagamiHiroo en-aut-sei=Kagami en-aut-mei=Hiroo kn-aut-name=加々美寛雄 kn-aut-sei=加々美 kn-aut-mei=寛雄 aut-affil-num=2 ORCID= en-aut-name=TazakiKoichi en-aut-sei=Tazaki en-aut-mei=Koichi kn-aut-name=田崎耕市 kn-aut-sei=田崎 kn-aut-mei=耕市 aut-affil-num=3 ORCID= en-aut-name=AsadaHitoshi en-aut-sei=Asada en-aut-mei=Hitoshi kn-aut-name=麻田斉 kn-aut-sei=麻田 kn-aut-mei=斉 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=広島大学 affil-num=2 en-affil= kn-affil=温泉地質学部門 affil-num=3 en-affil= kn-affil=温泉地質学部門 affil-num=4 en-affil= kn-affil=温泉地質学部門 END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue= article-no= start-page=1 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study of sulfur isotope exchange between S0(4)(2-) and H(2)S (aqueous) at 400℃ and 1000 bars water pressure kn-title=400℃, 1000気圧の熱水中におけるSO(2-)(4)-H(2)S間のイオウ同位体交換反応の実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Experimental procedures used in this study are the same as those developed by Sakai and Dickson (1978). 0.005 M Na(2)S(2)O(3) solutions were heated to 400℃ under 1000 bar water pressure in a gold bag of Dickson gold-bag equipment (Fig. 1). At an elevated temperature Na(2)S(2)O(3) quickly and completely decomposed into 1:1 mixture of SO(4)(2-) and H(2)S (eq. (1)) and subsequent isotope exchange (eq. (2)) was monitored by consecutively withdrawing aliquots of solution for chemical and isotopic analyses at desired time intervals. For the preparation of SO(2) for isotope analyses, 2 to 5 mg BaSO(4) was thoroughly mixed with silica glass powder of 10 times the BaSO(4) in weight and heated to 1400℃ or so in sealed, evacuated silica glass tubings (see Fig. 2 and equation (4)). The technique is a modification of Holt and Engelkemeir (1971). The (18)O/(16)O ratios of SO(2) thus formed stayed constant by exchange with silica glass powder (Fig. 3). Numerical data of the three runs performed in this study are summarized in Tables 1 to 3. In runs 2 and 3, a small aliquot of (34)S- enriched H(2)SO(4) was added into the starting solution and thus equilibrium was approached from above the quilibrium value (see Fig. 4). When isotope exchange occurs between two molecules, X and Y, the reaction rate, r, is related to the extent of exchange, F, at given time, t, by equation (17), where X and Y indicate concentrations of given species, α(e), α(o) and α denote the fractionation factor at equilibrium, at time t=0 and at an arbitrary time t, and F = (α - α(o))/(α(e) - α(0)) or the extent of isotope exchange. Assuming the exchange rate is of the first order with respect to both X and Y and to the β'th power of hydrogen ion activity, a(H)(+), eq. (17) reduces to eq. (19), where k(1) denotes the rate constant. If X, Y and pH of solution stayed constant during the run, the half-time, t(1/2), of the exchange reaction can be obtained graphically as shown in Fig. 5. The t(1/2) for runs 1, 2, and 3 are determined to be 5.8, 5.5 and 6.1 hrs, respectively. Introducing F=0.5 and t=t(1/2) into eq. (19), we obtain eq. (20) which is graphically shown in Fig. 6 using the data by the present work and those by Sakai and Dickson(1978). The numerical values of log k(1) + 0.16 may be obtained by extrapolating the lines to pH=0 and, from these values, the rate constant, k(1) , may be calculated for temperatures of 300° and 400℃. From these two values of k(1) and from the Arrhenius plot, the activation energy of the exchange reaction was calculated to be 22 kcal/mole, a much smaller value than 55 kcal/mole obtained by Igumnov (1977). The value of β is found to be 0.29 at 300℃ and 0.075 at 400℃, although the physico-chemical nature of β is not clear to the present authors. Using these values, eq. (24), where C is a constant, is derived which would enable us to calculate the t(1/2) of any system of known ΣS and pH. However, as we do not know yet how β varies with different systems, eq. (24) is applicable only to limited systems in which temperature, total sulfur contents and pH are similar to those of the present study. Fig. 7 illustrates how t(1/2) varies with pH and total sulfur content at 300° and 400℃ and predicts t(1/2) for some solutions obtainable by hydrothermal reactions of seawater with various igneous rocks. The average equilibrium fractionation factor at 400℃ obtained by this study is 1.0153, in good accord with 1.0151 given by Igumnov et al. (1977). Theoretical fractionation factors between SO(4)(2-) and H(2)S have been calculated by Sakai (1968) , who gives too high values compared to the experimental data obtained by this and other researchers (Fig. 9). In the present study, the reduced partition function ratio (R.P.F.R.) of SO(4)(2-) was recalculated using two sets of the vibrational frequencies of SO(4)(2-) (shown in Table 5) and the valence force fields of Heath and Linnett (1947), which reproduces the observed frequencies of SO(4)(2-) better than Urey-Bradley force field used by Sakai (1968). The results of new calculation are shown in Table 6. This table also includes the R.P.F.R. of H(2)S which was calculated by Thode et al. (1971). Using these new R.P.F.R. of SO(4)(2-) and H(2)S, the fractionation factors between SO(4)(2-) and H(2)S were calculated and are listed in the last column of Table 6 and plotted in Fig. 9. Fig. 9 indicates that the new calculation gives values more shifted from the experimental values than before. The major sulfate ions in our solution at 300° and 400℃ exist as NaSO(4)(-) (Sakai and Dickson, 1978; see also Table 4 of this paper) and, therefore, the measured fractionation factors are those between NaSO(4)(-) and H(2)S. The discrepancy between the theory and experiments may, at least, be partially explained by this fact, although other more important reasons, which are not known to us at the moment, may also exist. en-copyright= kn-copyright= en-aut-name=KamadaEmi en-aut-sei=Kamada en-aut-mei=Emi kn-aut-name=鎌田恵美 kn-aut-sei=鎌田 kn-aut-mei=恵美 aut-affil-num=1 ORCID= en-aut-name=SakaiHitoshi en-aut-sei=Sakai en-aut-mei=Hitoshi kn-aut-name=酒井均 kn-aut-sei=酒井 kn-aut-mei=均 aut-affil-num=2 ORCID= en-aut-name=KishimaNoriaki en-aut-sei=Kishima en-aut-mei=Noriaki kn-aut-name=木島宣明 kn-aut-sei=木島 kn-aut-mei=宣明 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所熱水地球化学部門 affil-num=2 en-affil= kn-affil=岡山大学温泉研究所熱水地球化学部門 affil-num=3 en-affil= kn-affil=岡山大学温泉研究所熱水地球化学部門 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue=1 article-no= start-page=147 end-page=158 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photoconductive and Photovoltaic Properties in Cadmium Bismuth Aluminate Glasses en-subtitle= kn-subtitle= en-abstract= kn-abstract=Photo-induced phenomena such as photoconductive and photovoltaic effects were investigated for the glasses in CdO-Bi(2)O(3)-Al(2)O(3) system. Photoconductive effect was characterized by a slow decay of photocurrent (persitent photoconductivity). The decay rate decreased with increasing CdO content and decreasing Bi(2)O(3) content. Photovoltage was very small at room temperature but increased to an obvious value on heating. The photoconductivity and photovoltage were increased with CdO content and enhanced by heat treatment in air. The valence band spectra of X-ray photoelectron spectroscopy showed that the hybridization of Cd 4d and O 2p orbitals increases with decreasing Bi(2)O(3) content and increasing CdO content in the glasses. As the results maximum tends to flat. This type of band structure inhibits the rapid recombination of electrons and holes. The persistent photoconductivity of the glasses may be attributed to deep energy level of DX centers. Deep energy levels of the glasses are able to prevent the recombination because they have a repulsive barrier for both electron emission and capture. en-copyright= kn-copyright= en-aut-name=ChenDanping en-aut-sei=Chen en-aut-mei=Danping kn-aut-name=陳丹平 kn-aut-sei=陳 kn-aut-mei=丹平 aut-affil-num=1 ORCID= en-aut-name=WatanabeTomohiro en-aut-sei=Watanabe en-aut-mei=Tomohiro kn-aut-name=渡辺智大 kn-aut-sei=渡辺 kn-aut-mei=智大 aut-affil-num=2 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=3 ORCID= en-aut-name=NanbaTokuro en-aut-sei=Nanba en-aut-mei=Tokuro kn-aut-name=難波徳郎 kn-aut-sei=難波 kn-aut-mei=徳郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Wuhan University of Technology affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=Photoconductivity kn-keyword=Photoconductivity en-keyword=Photovoltage kn-keyword=Photovoltage en-keyword=Persistent photoconductivity kn-keyword=Persistent photoconductivity en-keyword=CdO-Bi(2)O(3)-Al(2)O(3) glasses kn-keyword=CdO-Bi(2)O(3)-Al(2)O(3) glasses en-keyword=Electronic state kn-keyword=Electronic state END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=2 article-no= start-page=45 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Bioactive Calcium Borosilicate Glasses for Enameling Titanium en-subtitle= kn-subtitle= en-abstract= kn-abstract=The thermal expansion coefficient of some bioactive glasses in the system CaO-SiO(2)-B(2)O(3) were adjusted to be similar to that of titanium by controlling the composition. A glass of composition 45CaO・30SiO(2)・25B(2)O(3) was selected among those as the enameling glass. A slurry was prepared by mixing the glass powder and ethanal to be developed on titanium and heated at 740℃ for 30 min. Thus treated specimen was soaked in a simulated body fluid (Kokubo solutiion). FT-IR reflection and thin film X-ray diffraction analyses indicated apatite formation on the glass coating layer within 12 h of soaking in the fluid. Thus titanium could be provided with bioactivity due to the enameling. en-copyright= kn-copyright= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name=尾坂明義 kn-aut-sei=尾坂 kn-aut-mei=明義 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=KobayashiKeizo kn-aut-sei=Kobayashi kn-aut-mei=Keizo aut-affil-num=2 ORCID= en-aut-name=HayakawaSatoshi en-aut-sei=Hayakawa en-aut-mei=Satoshi kn-aut-name=早川聡 kn-aut-sei=早川 kn-aut-mei=聡 aut-affil-num=3 ORCID= en-aut-name=OhtsukiChikara en-aut-sei=Ohtsuki en-aut-mei=Chikara kn-aut-name=大槻主税 kn-aut-sei=大槻 kn-aut-mei=主税 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Bioengineering Science affil-num=2 en-affil= kn-affil=Department of Bioengineering Science affil-num=3 en-affil= kn-affil=Department of Bioengineering Science affil-num=4 en-affil= kn-affil=Department of Bioengineering Science END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=2 article-no= start-page=39 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Bioactivity of Nb(V) and Ta(V)-Doped Calcium Silicate Glasses en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nb(2)O(5)-and Ta(2)O(5)-doped calcium si1icate glasses were soaked for various periods in a simulated body fluid(Kokubo solution) up to 30 days. Apatite formation ability of the surface of these glasses were investigated with thin-film X-ray diffraction and FT-IR reflection spectroscopy. The effects of these additive oxides on the bioactivity of CaO・SiO(2) based glass were discussed. A small amount of Nb(2)O(5) and Ta(2)O(5) suppressed the rate of silica hydrogel layer formation and the apatite formation on the surface of the glasses. The rate of the apatite nucleation on the surface of Nb(2)O(5)-doped calcium silicate glass was slower than that on the surface of Ta(2)O(5)-doped calcium silicate glass. It was concluded that the decrease in the apatite forming ability of calcium silicate glasses by these additive oxides is attributed to the suppression of formation of silica hydrogel layer which plays an important role in apatite nucleation. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ImayoshiNaoki kn-aut-sei=Imayoshi kn-aut-mei=Naoki aut-affil-num=1 ORCID= en-aut-name=HayakawaSatoshi en-aut-sei=Hayakawa en-aut-mei=Satoshi kn-aut-name=早川聡 kn-aut-sei=早川 kn-aut-mei=聡 aut-affil-num=2 ORCID= en-aut-name=OhtsukiChikara en-aut-sei=Ohtsuki en-aut-mei=Chikara kn-aut-name=大槻主税 kn-aut-sei=大槻 kn-aut-mei=主税 aut-affil-num=3 ORCID= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name=尾坂明義 kn-aut-sei=尾坂 kn-aut-mei=明義 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=2 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=3 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=4 en-affil= kn-affil=Department of Bioscience and Biotechnology END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=7-8 article-no= start-page=805 end-page=817 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on experimental brain edema I. Basic considerations in measuring water content in the brain tissue by tritiated water ((3)H(2)O) kn-title=実験的脳浮腫に関する研究 第1編 Tritiated water((3)H(2)0)による脳組織水分含有量の測定 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author attempted to establish a new method of measuring water content in the brain tissue using tritiated water and a liquid scintillation counter. Approximately 50 mg of brain tissue was taken, put into a 1 ml disposable syringe and squeezed out in a centrifuge tube containing 2.5 ml of methylalcohol. This was then subjected to supersonication (by a supersonication bacterial homogenizer T-A-4201) for 3 minutes to prepare brain tissue homogenate. The homogenate was mixed in a glass vial with 20 ml of previously prepared scintillator for liquid scintillation counting. The author prepared six kinds of scintillators and investigated which scintillator was the best one in efficiency, and reproducibility for counting. The six kinds of scintillators were as follows: 1) Simple scintillator which was composed of one liter of toluene, 5 g of PPO and 300 mg of DM-POPOP. 2) Simple scintillator with 4 % Cab-o-sil. 3) Simple scintillator with 500 ml of Triton X 100. 4), 5) and 6) were the same composition as scintillators 1) to 3), but also had 50 ml of Soluene 100 added. The author concluded that the most suitable scintillator was No. 5 which was composed of simple scintillator, Cab-o-sil and Soluene 100. Next, the author examined the accuracy of this method in measuring the water content of brain tissue. Cold induced edema was produced in the right parietal region of rats. Half of the animals were untreated. The others were treated with 0.8 mg/Kg of dexamethasone after cold injury. The water content was calculated as follows: Ratio of increased water cpm/g of tritiated water in content in the injured = the injured hemisphere / cpm/g of tritiated water in ×100 hemisphere the non-injured hemisphere In the untreated animals, the water content in the injured side increased significantly from the control of 100.7±0.5 to 105.5±0.8 at 24 hours after cold injury. (Values are mean±S.D.) In the dexamethasone treated group, the water content in the injured side decreased significantly to 101.0±0.7 at 24 hours after injury. From these results, the author concluded that this new method might be an accurate, reproducible, unique and useful one for measuring the water content of brain tissue. en-copyright= kn-copyright= en-aut-name=IshimitsuHiroshi en-aut-sei=Ishimitsu en-aut-mei=Hiroshi kn-aut-name=石光宏 kn-aut-sei=石光 kn-aut-mei=宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科学教室 en-keyword=brain edema kn-keyword=brain edema en-keyword=water content kn-keyword=water content en-keyword=tritiated water kn-keyword=tritiated water en-keyword=liquid scintillation counting kn-keyword=liquid scintillation counting END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=1 article-no= start-page=97 end-page=105 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preparation and Dielectric Properties of [Ba,Sr]TiO(3)-Al(2)O(3)-SiO(2) Glass-Ceramics en-subtitle= kn-subtitle= en-abstract= kn-abstract=A series of ferroelectric glass-ceramics was elaborated by the controlled growth of Ba(1-x)Sr(x)TiO(3) crystal particles in the glass system 60[Ba(1-y)Sr(y)]TiO(3)-10Al(2)O(3)-30SiO(2)(0≦y≦0.2) in molar basis. Analysis of crystal phases by X-ray diffraction revealed that Sr content in Ba(1-x)Sr(x)TiO(3) increased with increasing content of SrO in glasses by its preferential transfer into the crystal phase, and the appropriate temperature for the crystal growth was 1100°C. Curie temperatures of glass -ceramics shifted to lower temperature with increasing SrO content in the crystal and comparatively high dielectric constant was obtained at room temperature for a glass-ceramics with y=0.2. Frequency dependences of dielectric constant and loss tangent were examined in the frequency range from 1 K to 1 M Hz. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=OdaKiichi kn-aut-sei=Oda kn-aut-mei=Kiichi aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=YoshioTetsuo kn-aut-sei=Yoshio kn-aut-mei=Tetsuo aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=O-okaKazuo kn-aut-sei=O-oka kn-aut-mei=Kazuo aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Research Institute for Non-Crystalline Materials affil-num=2 en-affil= kn-affil=Research Institute for Non-Crystalline Materials affil-num=3 en-affil= kn-affil=Research Institute for Non-Crystalline Materials END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=1 article-no= start-page=45 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19841126 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Preparation and Dielectric Properties of [Ba, Ca] TiO(3)-Al(2)O(3)-SiO(2) Glass-Ceramics en-subtitle= kn-subtitle= en-abstract= kn-abstract=Succeeding to 60(Ba,Sr)TiO(3)-10A1(2)O(3)-30SiO(2)glassceramics reported in our previous paper, another type of ferroelectric glass-ceramics was elaborated by the controlled growth of Ba(l-x)Ca(x)TiO(3) crystal particles in the glass system 60 (Ba(l-y)Ca(y)) TiO(3)-10Al(2)O(3)-30SiO(2) (0.0