検索条件

閉じる

検索結果 43 件

フルテキストURL fulltext20210706-1.pdf
著者 Doi, Seita| Fujioka, Naoki| Ohtsuka, Satomi| Kondo, Rina| Yamamoto, Maho| Denda, Miwako| Magari, Masaki| Kanayama, Naoki| Hatano, Naoya| Morishita, Ryo| Hasegawa, Takafumi| Tokumitsu, Hiroshi|
備考 ©2021 Elsevier BV. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ceca.2021.102404] .|
発行日 2021-6
出版物タイトル Cell Calcium
96巻
出版者 Elsevier BV
開始ページ 102404
ISSN 0143-4160
NCID AA00142099
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 Copyright © 2021 Elsevier Ltd. All rights reserved
論文のバージョン author
PubMed ID 33831707
DOI 10.1016/j.ceca.2021.102404
Web of Science KeyUT 000663580100007
関連URL isVersionOf https://doi.org/10.1016/j.ceca.2021.102404
フルテキストURL fulltext.pdf
著者 He, Fang| Matsumoto, Yoshinori| Asano, Yosuke| Yamamura, Yuriko| Katsuyama, Takayuki| La Rose, Jose| Tomonobu, Nahoko| Komalasari, Ni Luh Gede Yoni| Sakaguchi, Masakiyo| Rottapel, Robert| Wada, Jun|
キーワード ABL Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
備考 Erratum in https://ousar.lib.okayama-u.ac.jp/62331|
発行日 2021-05-31
出版物タイトル Frontiers In Oncology
11巻
出版者 Frontiers Media S.A.
開始ページ 665273
ISSN 2234-943X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, La Rose, Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
論文のバージョン publisher
PubMed ID 34136397
NAID 120007089841
DOI 10.3389/fonc.2021.665273
Web of Science KeyUT 000661158800001
関連URL isVersionOf https://doi.org/10.3389/fonc.2021.665273
フルテキストURL fulltext20210530_3.pdf
著者 Nakahara, Kengo| Hamada, Kyohei| Tsuchida, Tomoki| Takasugi, Nobumasa| Abiko, Yumi| Shien, Kazuhiko| Toyooka, Shinichi| Kumagai, Yoshito| Uehara, Takashi|
キーワード epidermal growth factor receptor cell signaling chemical modification signal transduction apoptosis
発行日 2021-12-31
出版物タイトル Journal of Biological Chemistry
296巻
出版者 Elsevier
開始ページ 100524
ISSN 00219258
NCID AA00251083
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2021 The Authors.
論文のバージョン publisher
PubMed ID 33705793
DOI 10.1016/j.jbc.2021.100524
関連URL isVersionOf https://doi.org/10.1016/j.jbc.2021.100524
フルテキストURL fulltext.pdf
著者 Martin, Eleanor R.| Barbieri, Alessandro| Ford, Robert C.| Robinson, Robert C.|
キーワード PDZ domain X-ray crystallography molecular modeling protein complex protein crystallization crystal structure cystic fibrosis transmembrane conductance regulator (CFTR) cystic fibrosis ion channel protein-protein interaction SLC9A3 regulator 1 (SLC9A3R1)
発行日 2020-04-03
出版物タイトル Journal of Biological Chemistry (JBC)
295巻
14号
出版者 American Society for Biochemistry and Molecular Biology
開始ページ 4464
終了ページ 4476
ISSN 0021-9258
NCID AA00251083
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 Martin et al.
論文のバージョン publisher
PubMed ID 32014995
DOI 10.1074/jbc.RA119.012015
Web of Science KeyUT 000524499700009
関連URL isVersionOf https://doi.org/10.1074/jbc.RA119.012015
フルテキストURL PNAS_117_33.pdf
著者 Akıl, Caner| Tran, Linh T.| Orhant-Prioux, Magali| Baskaran, Yohendran| Manser, Edward| Blanchoin, Laurent| Robinson, Robert C.|
キーワード actin gelsolin Asgard archaea eukaryogenesis X-ray crystallography
発行日 2020-08-18
出版物タイトル Proceedings of the National Academy of Sciences
出版者 National Academy of Sciences
開始ページ 117
終了ページ 33
ISSN 0027-8424
NCID AA10808769
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 Copyright © 2020 the Author(s)
論文のバージョン publisher
PubMed ID 32747565
DOI 10.1073/pnas.2009167117
Web of Science KeyUT 000567818600001
関連URL isVersionOf https://doi.org/10.1073/pnas.2009167117
フルテキストURL fulltext.pdf
著者 Bajkowska, Karolina| Sumardika, I. Wayan| Tomonobu, Nahoko| Chen, Youyi| Yamamoto, Ken-ichi| Kinoshita, Rie| Murata, Hitoshi| Gede Yoni Komalasari, Ni Luh| Jiang, Fan| Yamauchi, Akira| Winarsa Ruma, I. Made| Kasano-Camones, Carlos Ichiro| Inoue, Yusuke| Sakaguchi, Masakiyo|
キーワード Lung cancer Metastasis Epithelial-mesenchymal transition Solute carrier family 22 member 18 antisense S100A8/A9 Neuroplastin
発行日 2020-07
出版物タイトル Biochemistry and Biophysics Reports
22巻
出版者 Elsevier
開始ページ 100768
ISSN 24055808
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 The Authors
論文のバージョン publisher
PubMed ID 32490214
DOI 10.1016/j.bbrep.2020.100768
関連URL isVersionOf https://doi.org/10.1016/j.bbrep.2020.100768
フルテキストURL fulltext.pdf
著者 Miyata, Makoto| Robinson, Robert C.| Uyeda, Taro Q. P.| Fukumori, Yoshihiro| Fukushima, Shun‐ichi| Haruta, Shin| Homma, Michio| Inaba, Kazuo| Ito, Masahiro| Kaito, Chikara| Kato, Kentaro| Kenri, Tsuyoshi| Kinosita, Yoshiaki| Kojima, Seiji| Minamino, Tohru| Mori, Hiroyuki| Nakamura, Shuichi| Nakane, Daisuke| Nakayama, Koji| Nishiyama, Masayoshi| Shibata, Satoshi| Shimabukuro, Katsuya| Tamakoshi, Masatada| Taoka, Azuma| Tashiro, Yosuke| Tulum, Isil| Wada, Hirofumi| Wakabayashi, Ken‐ichi|
キーワード appendage cytoskeleton flagella membrane remodeling Mollicutes motor protein peptidoglycan three domains
発行日 2020-01-19
出版物タイトル Genes to Cells
25巻
1号
出版者 Wiley
開始ページ 6
終了ページ 21
ISSN 1356-9597
NCID AA11078945
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 The Authors.
論文のバージョン publisher
PubMed ID 31957229
DOI 10.1111/gtc.12737
Web of Science KeyUT 000507856400001
関連URL isVersionOf https://doi.org/10.1111/gtc.12737
フルテキストURL fulltext.pdf
著者 Gao, Shangze| Wake, Hidenori| Sakaguchi, Masakiyo| Wang, Dengli| Takahashi, Youhei| Teshigawara, Kiyoshi| Zhong, Hui| Mori, Shuji| Liu, Keyue| Takahashi, Hideo| Nishibori, Masahiro|
発行日 2020-06-26
出版物タイトル iScience
23巻
6号
出版者 Cell Press
開始ページ 101180
ISSN 2589-0042
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 The Authors.
論文のバージョン publisher
PubMed ID 32498020
DOI 10.1016/j.isci.2020.101180
Web of Science KeyUT 000548236600006
関連URL isVersionOf https://doi.org/10.1016/j.isci.2020.101180
フルテキストURL fulltext.pdf
著者 Nemoto, Michiko| Iwaki, Sayako| Moriya, Hisao| Monden, Yuki| Tamura, Takashi| Inagaki, Kenji| Mayama, Shigeki| Obuse, Kiori|
キーワード Biomineralization Diatom Silica Transcriptome Proteome
備考 This is a post-peer-review, pre-copyedit version of an article published in Marine Biotechnology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10126-020-09976-1.|
発行日 2020-06-03
出版物タイトル Marine Biotechnology
出版者 Springer
ISSN 1436-2228
NCID AA11357643
資料タイプ 学術雑誌論文
言語 フランス語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 32488507
DOI 10.1007/s10126-020-09976-1
Web of Science KeyUT 000537432000001
関連URL isVersionOf https://doi.org/10.1007/s10126-020-09976-1
JaLCDOI 10.18926/AMO/59950
フルテキストURL 74_3_199.pdf
著者 Fujita, Hirofumi| Bando, Tetsuya| Oyadomari, Seiichi| Ochiai, Kazuhiko| Watanabe, Masami| Kumon, Hiromi| Ohuchi, Hideyo|
抄録 Dickkopf 3 (Dkk3) is a secreted protein belonging to the Dkk family and encoded by the orthologous gene of REIC. Dkk3/REIC is expressed by mouse and human adrenal glands, but the understanding of its roles in this organ is still limited. To determine the functions of Dkk3 in the mouse adrenal gland, we first identified that the mouse Dkk3 protein is N-glycosylated in the adrenal gland as well as in the brain. We performed proteome analysis on adrenal glands from Dkk3-null mice, in which exons 5 and 6 of the Dkk3 gene are deleted. Twodimensional polyacrylamide gel electrophoresis of adrenal proteins from wild-type and Dkk3-null mice revealed 5 protein spots whose intensities were altered between the 2 genotypes. Mass spectrometry analysis of these spots identified binding immunoglobulin protein (BiP), an endoplasmic reticulum (ER) chaperone. To determine whether mouse Dkk3 is involved in the unfolded protein response (UPR), we carried out a reporter assay using ER-stress responsive elements. Forced expression of Dkk3 resulted in the induction of distinct levels of reporter expression, showing the UPR initiated by the ER membrane proteins of activating transcription factor 6 (ATF6) and inositol-requring enzyme 1 (IRE1). Thus, it is possible that Dkk3 is a physiological ER stressor in the mouse adrenal gland.
キーワード Dkk3 knockout mouse adrenal gland glucose-regulated protein 78 proteome endoplasmic reticulum stress
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-06
74巻
3号
出版者 Okayama University Medical School
開始ページ 199
終了ページ 208
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32577017
Web of Science KeyUT 000543363400003
NAID 120006862792
フルテキストURL BBRC_525_1_251_257.pdf
著者 Takabatake, Shota| Fukumoto, Yusei| Ohtsuka, Satomi| Kanayama, Naoki| Magari, Masaki| Sakagami, Hiroyuki| Hatano, Naoya| Tokumitsu, Hiroshi|
キーワード CaMKKβ Phosphorylation Dephosphorylation PP1 PP2A Okadaic acid
備考 This fulltext is available in Feb. 2021.|
発行日 2020-04-23
出版物タイトル Biochemical and Biophysical Research Communications
525巻
1号
出版者 Academic Press
開始ページ 251
終了ページ 257
ISSN 0006-291X
NCID AA00564395
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 32085894
DOI 10.1016/j.bbrc.2020.02.056
Web of Science KeyUT 000526797700039
関連URL isVersionOf https://doi.org/10.1016/j.bbrc.2020.02.056
JaLCDOI 10.18926/AMO/56649
フルテキストURL 73_2_135.pdf
著者 Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka|
抄録 The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization.
キーワード collagen XVIII basement membrane wound healing re-epithelialization skin
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-04
73巻
2号
出版者 Okayama University Medical School
開始ページ 135
終了ページ 146
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31015748
JaLCDOI 10.18926/AMO/55582
フルテキストURL 71_6_459.pdf
著者 Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi|
抄録 The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts.
キーワード receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2017-12
71巻
6号
出版者 Okayama University Medical School
開始ページ 459
終了ページ 465
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29276218
フルテキストURL J. Biol. Chem_292_23_9599.pdf
著者 Motomura, Taiki| Suga, Michihiro| Hienerwadel, Rainer| Nakagawa, Akiko| Lai, Thanh-Lan| Nitschke, Wolfgang| Kuma, Takahiro| Sugiura, Miwa| Boussac, Alain| Shen, Jian-Ren|
キーワード D1 protein His-Cys heme axial coordination PAS domain PAS-like domain Tll0287 X-ray crystallography cytochrome heme photosynthesis photosystem II
発行日 2017-06
出版物タイトル Journal of Biological Chemistry
292巻
23号
出版者 American Society for Biochemistry and Molecular Biology
開始ページ 9599
終了ページ 9612
ISSN 0021-9258
NCID AA00251083
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 28428249
DOI 10.1074/jbc.M116.746263
Web of Science KeyUT 000403113000012
関連URL isVersionOf https://doi.org/10.1074/jbc.M116.746263
著者 Yoshii, Taishi| Hermann-Luibl, Christiane| Kistenpfennig, Christa| Schmid, Benjamin| Tomioka, Kenji| Helfrich-Förster, Charlotte|
発行日 2015-04-15
出版物タイトル The Journal of neuroscience
35巻
15号
資料タイプ 学術雑誌論文
タイトル(別表記) The 2013 Incentive Award of the Okayama Medical Association in General Medical Science (2013 Yuuki Prize)
フルテキストURL 126_187.pdf
著者 山本 寛斉|
抄録 受賞対象論文: Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S:Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. J Natl Cancer Inst (2014) 106, djt338
出版物タイトル 岡山医学会雑誌
発行日 2014-12-01
126巻
3号
開始ページ 187
終了ページ 190
ISSN 0030-1558
言語 日本語
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.126.187
NAID 130004903235
著者 Putranto, Endy Widya| Murata, Hitoshi| Yamamoto, Ken-Ichi| Kataoka, Ken| Yamada, Hidenori| Futami, Jun-Ichiro| Sakaguchi, Masakiyo| Huh, Nam-Ho|
発行日 2013-10
出版物タイトル International Journal of Molecular Medicine
32巻
4号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/51064
フルテキストURL 67_4_203.pdf
著者 Ohuchi, Hideyo|
抄録 A central issue of evolutionary developmental biology is how the eye is diverged morphologically and functionally. However, the unifying mechanisms or schemes that govern eye diversification remain unsolved. In this review, I first introduce the concept of evolutionary developmental biology of the eye with a focus on photoreception, the fundamental property of retinal cells. Second, I summarize the early development of vertebrate eyes and the role of a homeobox gene, Lhx1, in subdivision of the retina into 2 domains, the neural retina and retinal pigmented epithelium of the optic primordium. The 2 retinal domains are essential components of the eye as they are found in such prototypic eyes as the extant planarian eye. Finally, I propose the presence of novel retinal cell subtypes with photosensory functions based on our recent work on atypical photopigments (opsins) in vertebrates. Since human diseases are attributable to the aberration of various types of cells due to alterations in gene expression, understanding the precise mechanisms of cellular diversification and unraveling the molecular profiles of cellular subtypes are essential to future regenerative medicine.
キーワード eye development evolution opsin photoreceptor
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2013-08
67巻
4号
出版者 Okayama University Medical School
開始ページ 203
終了ページ 212
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23970318
Web of Science KeyUT 000323470100001
著者 Zong, Min| Satoh, Ayano| Yu, Mei Kuen| Siu, Ka Yu| Ng, Wing Yan| Chan, Hsiao Chang| Tanner, Julian A.| Yu, Sidney|
発行日 2012-01-18
出版物タイトル PLoS ONE
7巻
1号
資料タイプ 学術雑誌論文
著者 Ohtsuki, Takashi| Otsuki, Mariko| Murakami, Yousuke| Maekawa, Tetsuya| Yamamoto, Takashi| Akasaka, Koji| Takeuchi, Sakae| Takahashi, Sumio|
発行日 2005-09
出版物タイトル Zoological Science
22巻
9号
資料タイプ 学術雑誌論文